keyword
https://read.qxmd.com/read/38414997/association-of-low-vitamin-d-and-intact-parathyroid-hormone-ipth-in-nepalese-population-when-does-ipth-exactly-rise
#21
JOURNAL ARTICLE
Sujata Baidya, Eans Tara Tuladhar, Vijay Kumar Sharma, Raju Kumar Dubey, Mithileshwer Raut, Aseem Bhattarai, Naresh Parajuli, Apeksha Niraula
Vitamin D deficiency is a global public health concern that provokes bone demineralization and weakening. In response to the decreased vitamin D level, calcium stores wear out. The homeostatic effect of compensatory hyperparathyroidism in vitamin D deficiency incites variable discrepancies in different populations. This study intends to decipher the transition point of PTH in relation to levels of vitamin D in a Nepalese population. A cross-sectional study was carried out at Tribhuvan University Teaching Hospital, Nepal...
February 19, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38406062/evaluation-and-in-vitro-study-of-an-electrospun-bone-tissue-membrane-for-bone-regeneration-a-novel-perspective
#22
JOURNAL ARTICLE
Nazurudeen Jabeen, Anitha Roy, Rethinam Senthil
Objectives In the present study, electrospun bone tissue membrane (EBTM) was prepared using polyvinylidene fluoride (PVDF), gelatin (gel), and demineralized bone matrix (DBM) by electrospinning method for its potential application in bone tissue regeneration. Materials and methods The prepared EBTM was evaluated using high-resolution scanning electron microscopy (HR-SEM), energy-dispersive X-ray spectroscopy (EDX; Silicon Drift 2017, USA), thermogravimetric analysis (TGA), and mechanical properties such as tensile strength (MPa), elongation at break (%), flexibility (%), and water absorption (%)...
January 2024: Curēus
https://read.qxmd.com/read/38399552/comparison-of-fusion-rates-among-various-demineralized-bone-matrices-in-posterior-lumbar-interbody-fusion
#23
JOURNAL ARTICLE
Sanghoon Lee, Dae-Woong Ham, Ohsang Kwon, Joon-Hee Park, Youngsang Yoon, Ho-Joong Kim
Background and Objectives : Posterior lumbar interbody fusion (PLIF) plays a crucial role in addressing various spinal disorders. The success of PLIF is contingent upon achieving bone fusion, as failure can lead to adverse clinical outcomes. Demineralized bone matrix (DBM) has emerged as a promising solution for promoting fusion due to its unique combination of osteoinductive and osteoconductive properties. This study aims to compare the effectiveness of three distinct DBMs (Exfuse® , Bongener® , and Bonfuse® ) in achieving fusion rates in PLIF surgery...
February 2, 2024: Medicina
https://read.qxmd.com/read/38396761/the-effects-of-acid-on-calcium-and-phosphate-metabolism
#24
REVIEW
Juan D Salcedo-Betancourt, Orson W Moe
A variety of changes in mineral metabolism aiming to restore acid-base balance occur in acid loading and metabolic acidosis. Phosphate plays a key role in defense against metabolic acidosis, both as an intracellular and extracellular buffer, as well as in the renal excretion of excess acid in the form of urinary titratable acid. The skeleton acts as an extracellular buffer in states of metabolic acidosis, as the bone matrix demineralizes, leading to bone apatite dissolution and the release of phosphate, calcium, carbonate, and citrate into the circulation...
February 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38391880/composite-remineralization-of-bone-collagen-matrices-by-low-temperature-ceramics-and-serum-albumin-a-new-approach-to-the-creation-of-highly-effective-osteoplastic-materials
#25
JOURNAL ARTICLE
Vladislav V Minaychev, Anastasia Yu Teterina, Polina V Smirnova, Ksenia A Menshikh, Anatoliy S Senotov, Margarita I Kobyakova, Igor V Smirnov, Kira V Pyatina, Kirill S Krasnov, Roman S Fadeev, Vladimir S Komlev, Irina S Fadeeva
This study examined the effectiveness of coating demineralized bone matrix (DBM) with amorphous calcium phosphate (DBM + CaP), as well as a composite of DBM, calcium phosphate, and serum albumin (DBM + CaP + BSA). The intact structure of DBM promotes the transformation of amorphous calcium phosphate (CaP) into dicalcium phosphate dihydrate (DCPD) with a characteristic plate shape and particle size of 5-35 µm. The inclusion of BSA in the coating resulted in a better and more uniform distribution of CaP on the surface of DBM trabeculae...
January 23, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38365457/natural-biphasic-calcium-phosphate-from-fish-bones-for-enamel-remineralization-and-dentin-tubules-occlusion
#26
JOURNAL ARTICLE
Lorenzo Degli Esposti, Andrei C Ionescu, Sara Gandolfi, Nicoleta Ilie, Alessio Adamiano, Eugenio Brambilla, Michele Iafisco
OBJECTIVES: A calcium phosphate extracted from fish bones (CaP-N) was evaluated for enamel remineralization and dentinal tubules occlusion. METHODS: CaP-N was characterized by assessing morphology by SEM, crystallinity by PXRD, and composition by ICP-OES. CaP-N morphology, crystallinity, ion release, and pH changes over time in neutral and acidic solutions were studied. CaP-N was then tested to assess remineralization and dentinal tubules occlusion on demineralized human enamel and dentin specimens (n = 6)...
February 16, 2024: Dental Materials
https://read.qxmd.com/read/38349005/successive-protein-extraction-using-hydroxylamine-to-increase-the-depth-of-proteome-coverage-in-fresh-forensic-and-archaeological-bones
#27
JOURNAL ARTICLE
Catherine Gilbert, Katell Bathany, Stéphane Claverol, Quentin Scanvion, Valery Hedouin, Benoit Bertrand, Caroline Tokarski
Proteomics is continually being applied to a wider range of applications, now including the analysis of archaeological samples and anatomical specimens, particularly collagen-containing tissues such as bones and teeth. Here, we present the application of a chemical digestion-based proteomics sample preparation protocol to the analysis of fresh, anatomical, and archaeological samples. We describe and discuss two protocols: one that uses hydroxylamine as an additional step of the proteomic workflow, applied to the insoluble fraction, and another that applies hydroxylamine directly on demineralized bones and teeth...
February 13, 2024: Analytical Chemistry
https://read.qxmd.com/read/38343300/a-physicochemical-evaluation-of-ossein-hydroxyapatite-within-the-bovine-bone-matrix-revealed-demineralization-and-making-type-i-collagen-available-as-a-result-of-processing-and-solubilization-by-acids
#28
JOURNAL ARTICLE
Vanessa Ricas Biancardi, Marcus Vinícius da Silva Ferreira, Antônio Renato Bigansolli, Karine Moura de Freitas, Everaldo Zonta, Maria Ivone Martins Jacintho Barbosa, Louise Emy Kurozawa, José Lucena Barbosa Junior
Bovine bone is an animal-origin matrix rich in type I collagen (COL I) and it necessitates prior demineralization and makes COL I available. This study investigated the ossein-hydroxyapatite physicochemical properties evaluation as a result of processing and solubilization by acids and revealed the bone matrix demineralization and making COL I available. The tibia residue from bovine sources was processed, ground, and transformed into bone matrix powder. The bone matrix was solubilized in acetic acid followed by lactic acid...
February 11, 2024: Journal of Food Science
https://read.qxmd.com/read/38329506/histomorphometric-analysis-of-patients-with-femoral-neck-fracture-and-25-hydroxyvitamin-d-deficiency-a-cross-sectional-study
#29
JOURNAL ARTICLE
Go Okumura, Noriaki Yamamoto, Hayato Suzuki, Hiroshi Ninomiya, Yuki Hirano, Yoshiaki Tei, Yasuyuki Tomiyama, Taketoshi Shimakura, Hideaki E Takahashi, Norio Imai, Hiroyuki Kawashima
INTRODUCTION: Vitamin D deficiency causes osteoporosis, bone mineralization disorders, and osteomalacia. Osteomalacia is diagnosed using blood biochemical tests, clinical symptoms, and imaging; however, accurate detection of mineralization disorders requires tissue observation. We investigated the prevalence of bone mineralization disorders and their relationship with serum 25-hydroxyvitamin D (25OHD) levels in patients with untreated osteoporosis with femoral neck fractures. MATERIALS AND METHODS: A non-demineralized specimen was prepared from the femoral head removed during surgery in 65 patients...
February 8, 2024: Journal of Bone and Mineral Metabolism
https://read.qxmd.com/read/38323368/the-development-of-non-resorbable-bone-allografts-biological-background-and-clinical-perspectives
#30
REVIEW
Richard J Miron, Masako Fujioka-Kobayashi, Michael A Pikos, Toshiaki Nakamura, Takatomo Imafuji, Yufeng Zhang, Yukiya Shinohara, Anton Sculean, Yoshinori Shirakata
Bone grafts are typically categorized into four categories: autografts, allografts, xenografts, and synthetic alloplasts. While it was originally thought that all bone grafts should be slowly resorbed and replaced with native bone over time, accumulating evidence has in fact suggested that the use of nonresorbable xenografts is favored for certain clinical indications. Thus, many clinicians take advantage of the nonresorbable properties/features of xenografts for various clinical indications, such as contour augmentation, sinus grafting, and guided bone regeneration, which are often combined with allografts (e...
February 7, 2024: Periodontology 2000
https://read.qxmd.com/read/38322815/early-results-on-the-efficacy-of-demineralized-bone-matrix-bone-morphogenic-protein-and-freeze-dried-bone-chips-in-alveolar-cleft-repair
#31
JOURNAL ARTICLE
Jessica L Marquez, Jack Sudduth, Henning DeMay, Keith Kuo, Andrea Battistini, Duane K Yamashiro, Faizi A Siddiqi, Barbu Gociman
BACKGROUND: Conventional treatment for alveolar cleft repair is done using autologous iliac crest alveolar bone graft (ABG). However, this method may not be ideal in all patients. Analysis of the efficacy of a mixture of demineralized bone matrix (DBX), bone morphogenic protein (rhBMP-2), and freeze-dried bone chips (FDBC) as an alternative for alveolar cleft repair was performed. METHODS: Consecutive patients from August 2019 to June 2022 undergoing early alveolar cleft repair, concomitant hard palate and alveolar cleft repair, secondary alveolar cleft repair, and regrafting from a previously failed ABG were analyzed...
February 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38316791/eosinophils-preserve-bone-homeostasis-by-inhibiting-excessive-osteoclast-formation-and-activity-via-eosinophil-peroxidase
#32
JOURNAL ARTICLE
Darja Andreev, Katerina Kachler, Mengdan Liu, Zhu Chen, Brenda Krishnacoumar, Mark Ringer, Silke Frey, Gerhard Krönke, David Voehringer, Georg Schett, Aline Bozec
Eosinophils are involved in tissue homeostasis. Herein, we unveiled eosinophils as important regulators of bone homeostasis. Eosinophils are localized in proximity to bone-resorbing osteoclasts in the bone marrow. The absence of eosinophils in ΔdblGATA mice results in lower bone mass under steady-state conditions and amplified bone loss upon sex hormone deprivation and inflammatory arthritis. Conversely, increased numbers of eosinophils in IL-5 transgenic mice enhance bone mass under steady-state conditions and protect from hormone- and inflammation- mediated bone loss...
February 5, 2024: Nature Communications
https://read.qxmd.com/read/38309695/oral-biosciences-the-annual-review-2023
#33
EDITORIAL
Hayato Ohshima, Kenji Mishima
BACKGROUND: Journal of Oral Biosciences is dedicated to advancing and disseminating fundamental knowledge concerning every aspect of oral biosciences. This review features review articles in the fields of "bone regeneration," "periodontitis," "periodontal diseases," "salivary glands," "sleep bruxism," and "Sjögren's syndrome." HIGHLIGHT: This review focused on human demineralized dentin/cementum matrix for bone regeneration, oxidized low-density lipoprotein in periodontal disease and systemic conditions, the relationship between inflammatory mediators in migraine and periodontitis, phosphoinositide signaling molecules in the salivary glands, and the pathophysiology of sleep bruxism and Sjögren's syndrome...
February 1, 2024: Journal of Oral Biosciences
https://read.qxmd.com/read/38276563/high-protein-diets-during-either-resistance-or-concurrent-training-have-no-detrimental-effect-on-bone-parameters-in-resistance-trained-males
#34
JOURNAL ARTICLE
Reza Bagheri, Zohreh Karimi, Zeynabalsadat Mousavi, Mahdi Ziaee Bashirzad, Donny M Camera, Ramin Sadeghi, Vahid Reza Dabbagh, Mehdi Kargarfard, Frederic Dutheil
BACKGROUND: The effects of combining resistance training (RT) and concurrent training (CT; resistance + endurance training) with varied protein doses on bone measures remain poorly understood. Hence, we conducted a comparison of the impacts of two high-protein diets (1.6 or 3.2 g kg-1 d-1 ) over 16 weeks in resistance-trained males, either with CT or RT alone. METHODS: A total of forty-eight males, all of whom were resistance-trained, had the following demographics: 26...
January 22, 2024: Nutrients
https://read.qxmd.com/read/38275216/self-assembled-nanocomposite-hydrogels-as-carriers-for-demineralized-bone-matrix-particles-and-enhanced-bone-repair
#35
JOURNAL ARTICLE
Chen Chen, Zhi Li, Changlu Xu, Minjee Kang, Chung-Sung Lee, Tara Aghaloo, Min Lee
Demineralized bone matrix (DBM) has been widely used as an allogeneic alternative to autologous bone graft for bone repair. However, more extensive use of DBM is limited due to its particulate nature after demineralization and rapid particle dispersion following irrigation, resulting in unpredictable osteoinductivity. Here, we report a new design of injectable hydrogel carriers for DBM that combine self-healing ability and osteogenic properties based on the self-assembly of guanidinylated hyaluronic acid and silica-rich nanoclays...
January 26, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38271376/correction-evaluation-of-the-osteogenic-potential-of-demineralized-and-decellularized-bovine-bone-granules-following-implantation-in-rat-calvaria-critical-size-defect-model
#36
Ali Al Qabbani, K G Aghila Rani, Sausan AlKawas, Suzina Sheikh Abdul Hamid, Johari Yap Abdullah, A R Samsudin, Ahmad Azlina
[This corrects the article DOI: 10.1371/journal.pone.0294291.].
2024: PloS One
https://read.qxmd.com/read/38254433/impact-of-perch-provision-timing-on-activity-and-musculoskeletal-health-of-laying-hens
#37
JOURNAL ARTICLE
Mallory G Anderson, Alexa M Johnson, Cerano Harrison, Mireille Arguelles-Ramos, Ahmed Ali
Laying hens can experience a progressive increase in bone fragility due to the ongoing mobilization of calcium from bones for eggshell formation. Over time, this escalates their susceptibility to bone fracture, which can reduce their mobility and cause pain. The provision of perches as an exercise opportunity could potentially enhance bone strength, but the timing of exposure to perches during the birds' development may modulate its impact. The objective of this study was to investigate the enduring impacts of perch provision timing on the musculoskeletal health of laying hens...
January 15, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38248471/stimulation-of-osteogenic-activity-of-autologous-teeth-hard-tissues-as-bone-augmentation-material
#38
JOURNAL ARTICLE
Jan Kučera, František Lofaj, Zuzana Nagyová-Krchova, Natália Šurín Hudáková, Marek Vojtko, Vitěslav Březina
The issue of bone volume loss is playing an increasing role in bone tissue engineering. Research has focused on studying the preparation and use of different types of human or xenogenic materials and their osteogenic properties. An alternative source for this purpose could be autologous extracted teeth. The simple preparation protocol, minimal immune response, and rapid organizing of the newly formed bone with optimal mechanical properties predispose autologous hard teeth tissues (HTTs) as a promising material suitable in the indication of augmentation of maxillary and mandible defects, comparable to other high-end augmentation materials...
January 11, 2024: Biology
https://read.qxmd.com/read/38247243/enhanced-osteogenicity-of-the-demineralized-bone-dermal-matrix-composite-by-the-optimal-partial-demineralization-for-sustained-release-of-bioactive-molecules
#39
JOURNAL ARTICLE
Tong Ma, Dangli Ren, Jingjing Wang, Feng Fu, Wendell Q Sun, Hongtao Sun
Allogenic demineralized bone matrix (DBM), processed to expose bioactive proteins imbedded by calcium salts, is widely used for bone repair and regeneration as an alternative to the autologous bone graft. However, demineralized bone matrices from tissue banks vary significantly in residual calcium content and osteogenicity for clinical bone regeneration. The present study produced DBM with various residual calcium contents by partial demineralization using ethylenediaminetetraacetic acid disodium (EDTA) and hydrochloric acid...
January 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38242930/adaptable-test-bench-for-astm-compliant-permeability-measurement-of-porous-scaffolds-for-tissue-engineering
#40
JOURNAL ARTICLE
Stefano Gabetti, Beatrice Masante, Alessandro Schiavi, Elisa Scatena, Eleonora Zenobi, Simone Israel, Alessandro Sanginario, Costantino Del Gaudio, Alberto Audenino, Umberto Morbiducci, Diana Massai
Intrinsic permeability describes the ability of a porous medium to be penetrated by a fluid. Considering porous scaffolds for tissue engineering (TE) applications, this macroscopic variable can strongly influence the transport of oxygen and nutrients, the cell seeding process, and the transmission of fluid forces to the cells, playing a crucial role in determining scaffold efficacy. Thus, accurately measuring the permeability of porous scaffolds could represent an essential step in their optimization process...
January 19, 2024: Scientific Reports
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