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https://www.readbyqxmd.com/read/27890676/combined-in-vitro-and-in-silico-approaches-to-the-assessment-of-stimulant-properties-of-novel-psychoactive-substances-the-case-of-the-benzofuran-5-mapb
#1
Michelle A Sahai, Colin Davidson, George Khelashvili, Vincenzo Barrese, Neelakshi Dutta, Harel Weinstein, Jolanta Opacka-Juffry
Novel psychoactive substances (NPS) are increasingly prevalent world-wide although their pharmacological characteristics are largely unknown; those with stimulant properties, due to interactions with the dopamine transporter (DAT), have addictive potential which their users may not realise. We evaluated the binding of 1-(1-benzofuran-5-yl)-N-methylpropan-2-amine (5-MAPB) to rat striatal DAT by means of quantitative autoradiography with [(125)I]RTI-121, and the effects of 5-MAPB on electrically-evoked dopamine efflux by fast-cyclic voltammetry in rat brain slices...
November 24, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27889577/brain-uptake-and-metabolism-of-the-endocannabinoid-anandamide-labeled-in-either-the-arachidonoyl-or-ethanolamine-moiety
#2
Kun Hu, Shilpa Sonti, Sherrye T Glaser, Richard I Duclos, Samuel J Gatley
INTRODUCTION: Anandamide (N-arachidonoylethanolamine) is a retrograde neuromodulator that activates cannabinoid receptors. The concentration of anandamide in the brain is controlled by fatty acid amide hydrolase (FAAH), which has been the focus of recent drug discovery efforts. Previous studies in C57BL/6 mice using [(3)H-arachidonoyl]anandamide demonstrated deposition of tritium in thalamus and cortical areas that was blocked by treatment with an FAAH inhibitor and that was not seen in FAAH-knockout mice...
November 9, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27887585/reduction-in-antibiotic-prescribing-for-respiratory-tract-infections-in-swedish-primary-care-a-retrospective-study-of-electronic-patient-records
#3
Mia Tyrstrup, Anders Beckman, Sigvard Mölstad, Sven Engström, Christina Lannering, Eva Melander, Katarina Hedin
BACKGROUND: Swedish studies on antibiotic use in primary care have been based on one-week registrations of infections. In order to study adherence to guidelines, analyses based on large databases that provide information on diagnosis linked prescriptions, are needed. This study describes trends in management of infections in Swedish primary care particularly with regards to antibiotic prescribing and adherence to national guidelines. METHODS: A descriptive study of Sweden's largest database regarding diagnosis linked antibiotic prescription data, the Primary care Record of Infections in Sweden (PRIS), for the years 2008, 2010 and 2013...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27886504/controlling-rayleigh-taylor-instabilities-in-magnetically-driven-solid-metal-shells-by-means-of-a-dynamic-screw-pinch
#4
P F Schmit, A L Velikovich, R D McBride, G K Robertson
Magnetically driven implosions of solid metal shells are an effective vehicle to compress materials to extreme pressures and densities. Rayleigh-Taylor instabilities (RTI) are ubiquitous, yet typically undesired features in all such experiments where solid materials are rapidly accelerated to high velocities. In cylindrical shells ("liners"), the magnetic field driving the implosion can exacerbate the RTI. We suggest an approach to implode solid metal liners enabling a remarkable reduction in the growth of magnetized RTI (MRTI) by employing a magnetic drive with a tilted, dynamic polarization, forming a dynamic screw pinch...
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27881530/menstrual-cups-and-sanitary-pads-to-reduce-school-attrition-and-sexually-transmitted-and-reproductive-tract-infections-a-cluster-randomised-controlled-feasibility-study-in-rural-western-kenya
#5
Penelope A Phillips-Howard, Elizabeth Nyothach, Feiko O Ter Kuile, Jackton Omoto, Duolao Wang, Clement Zeh, Clayton Onyango, Linda Mason, Kelly T Alexander, Frank O Odhiambo, Alie Eleveld, Aisha Mohammed, Anna M van Eijk, Rhiannon Tudor Edwards, John Vulule, Brian Faragher, Kayla F Laserson
OBJECTIVES: Conduct a feasibility study on the effect of menstrual hygiene on schoolgirls' school and health (reproductive/sexual) outcomes. DESIGN: 3-arm single-site open cluster randomised controlled pilot study. SETTING: 30 primary schools in rural western Kenya, within a Health and Demographic Surveillance System. PARTICIPANTS: Primary schoolgirls 14-16 years, experienced 3 menses, no precluding disability, and resident in the study area...
November 23, 2016: BMJ Open
https://www.readbyqxmd.com/read/27878129/an-epidemiological-study-of-road-traffic-accidents-in-guilan-province-northern-iran-in-2012
#6
Zahra Mohtasham-Amiri, Saeed Dastgiri, Ali Davoudi-Kiakalyeh, Ali Imani, Keyvan Mollarahimi
OBJECTIVE: To determine the epidemiological characteristics of the road traffic injuries (RTIs) in Guilan province, northern Iran. METHODS: This study was a cross-sectional study which included all of RTIs admitted to medical centers of Guilan province (northern Iran) during 2012. ICD-10 was used as diagnostic criteria. Demographic variables also injury circumstance and in hospital variables such as length of stay, time of admission, type of surgery, ICU admission, final outcome and mechanism of injury, anatomical part of injury according to Abbreviated Injury Scale (AIS) classification were derives from records by trained research team...
October 2016: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/27868167/the-role-of-ugandan-district-hospital-orthopedic-units-in-the-care-of-vulnerable-road-users-a-cross-sectional-study
#7
Dan K Kisitu, Lauren E Eyler, Isaac Kajja, Gonzaga Waiswa, Titus Beyeza, David R Ragland, Isabelle Feldhaus, Catherine Juillard, Rochelle A Dicker
BACKGROUND: Musculoskeletal injuries are a common cause of morbidity after road traffic injury (RTI) in motorizing countries. District hospitals provide front-line orthopedic care in Uganda and other sub-Saharan African nations. Improving care at the district hospital level is an important component of the World Health Organization's strategy for surgical and trauma systems strengthening, but the data necessary to inform RTI safety and care initiatives has previously been insufficient at the district hospital level...
December 2016: Injury Epidemiology
https://www.readbyqxmd.com/read/27864242/understanding-the-delayed-prescribing-of-antibiotics-for-respiratory-tract-infection-in-primary-care-a-qualitative-analysis
#8
R Ryves, C Eyles, M Moore, L McDermott, P Little, G M Leydon
OBJECTIVE: To identify general practitioner (GP) views and understanding on the use of delayed prescribing in primary care. DESIGN: Qualitative semistructured telephone interview study. SETTING: Primary care general practices in England. PARTICIPANTS: 32 GPs from identified high-prescribing and low-prescribing general practices in England. METHOD: Semistructured telephone interviews were conducted with GPs identified from practices within clinical commissioning groups with the highest and lowest prescribing rates in England...
November 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27853316/the-association-between-meteorological-factors-and-road-traffic-injuries-a-case-analysis-from-shantou-city-china
#9
Jinghong Gao, Xiaojun Chen, Alistair Woodward, Xiaobo Liu, Haixia Wu, Yaogui Lu, Liping Li, Qiyong Liu
Few studies examined the associations of meteorological factors with road traffic injuries (RTIs). The purpose of the present study was to quantify the contributions of meteorological factors to RTI cases treated at a tertiary level hospital in Shantou city, China. A time-series diagram was employed to illustrate the time trends and seasonal variation of RTIs, and correlation analysis and multiple linear regression analysis were conducted to investigate the relationships between meteorological parameters and RTIs...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27852324/development-of-a-prognostic-model-based-on-demographic-environmental-and-lifestyle-information-for-predicting-incidences-of-symptomatic-respiratory-or-gastrointestinal-infection-in-adult-office-workers
#10
Tapani Hovi, Jukka Ollgren, Jaason Haapakoski, Carita Savolainen-Kopra
BACKGROUND: Occurrence of respiratory tract infection (RTI) or gastrointestinal tract infection (GTI) is known to vary between individuals and may be a confounding factor in the analysis of the results of intervention trials. We aimed at developing a prognostic model for predicting individual incidences of RTI and GTI on the basis of data collected in a hand-hygiene intervention trial among adult office workers, and comprising a prior-to-onset questionnaire on potential infection-risk factors and weekly electronic follow-up reports on occurrence of symptoms of, and on exposures to RTI or GTI...
November 16, 2016: Trials
https://www.readbyqxmd.com/read/27852263/regional-disparities-in-road-traffic-injuries-and-their-determinants-in-brazil-2013
#11
Otaliba Libanio Morais Neto, Ana Lúcia Andrade, Rafael Alves Guimarães, Polyana Maria Pimenta Mandacarú, Gabriela Camargo Tobias
BACKGROUND: In recent decades middle-income countries have experienced a rapid increase in the number of cars and motorcycles. Increased deaths and hospitalizations due to road traffic injuries (RTI) has been observed in several countries as a result. In this study we assessed the determinants of RTIs in Brazil by mode of transportation and compared differences in RTI rates among macro-regions. METHODS: We used data from the National Health Survey (NHS) conducted in 2013 by the Brazilian Institute of Geography and Statistics and the Ministry of Health...
November 17, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27851908/n-phenylpropyl-n-substituted-piperazines-occupy-sigma-receptors-and-alter-methamphetamine-induced-hyperactivity-in-mice
#12
Dennis K Miller, Eric S Park, Susan Z Lever, John R Lever
This study examined the effect of the N-phenylpropyl-N'-substituted piperazine ligands SA4503 (3.4-dimethoxyphenethyl), YZ-067 (4-methoxyphenethyl), YZ-185 (3-methoxyphenethyl) and Nahas-3h (4-methoxybenzyl) on methamphetamine-induced hyperactivity in mice. In a previous study in rats, SA4503 increased methamphetamine-induced hyperactivity at a lower ligand dose and enhanced it at a higher dose. The other ligands have not been investigated in this assay. Presently, mice were administered sigma ligands, and specific [(125)I]E-IA-DM-PE-PIPZE and [(125)I]RTI-121 binding was measured to determine σ1 sigma receptor and dopamine transporter occupancy, respectively...
November 13, 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27851668/instability-resistance-training-improves-neuromuscular-outcome-in-parkinson-s-disease
#13
Carla Silva-Batista, Daniel Montie Corcos, Renato Barroso, Fabian J David, Hélcio Kanegusuku, Cláudia Forjaz, Marco Túlio de Mello, Hamilton Roschel, Valmor Tricoli, Carlos Ugrinowitsch
PURPOSE: This study compared the effects of resistance training (RT) and resistance training with instability (RTI) on neuromuscular and total training volume (TTV) outcomes obtained as part of the Instability Resistance Training Trial in Parkinson's disease (IRRT-PD). It also used a linear multiple regression (forward stepwise method) to identify the contribution of neuromuscular outcomes to previously published improvements in the timed-up-and-go-test and the Unified Parkinson's Disease Rating Scale, motor subscale score (UPDRS-III)...
November 16, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27834670/resistance-training-with-instability-is-more-effective-than-resistance-training-in-improving-spinal-inhibitory-mechanisms-in-parkinson-s-disease
#14
Carla Silva-Batista, Eugenia Casella Tavares Mattos, Daniel M Corcos, Jessica M Wilson, Charles J Heckman, Helcio Kanegusuku, Maria Elisa Pimentel Piemonte, Marco Túlio de Mello, Claudia Lucia de Moraes Forjaz, Hamilton Roschel, Valmor Alberto Tricoli, Carlos Ugrinowitsch
BACKGROUND: This study assessed: 1) the effects of 12 weeks of resistance training (RT) and resistance training with instability (RTI) on presynaptic inhibition (PSI) and disynaptic reciprocal inhibition (DRI) of patients with Parkinson's disease (PD); 2) the effectiveness of RT and RTI in moving PSI and DRI values of patients towards values of age-matched healthy controls (HC [Z-score analysis]); and 3) associations between PSI and DRI changes and clinical outcomes changes previously published...
November 10, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27833597/comparison-of-mycoplasma-pneumoniae-genome-sequences-from-strains-isolated-from-symptomatic-and-asymptomatic-patients
#15
Emiel B M Spuesens, Rutger W W Brouwer, Kristin H J M Mol, Theo Hoogenboezem, Christel E M Kockx, Ruud Jansen, Wilfred F J Van IJcken, Annemarie M C Van Rossum, Cornelis Vink
Mycoplasma pneumoniae is a common cause of respiratory tract infections (RTIs) in children. We recently demonstrated that this bacterium can be carried asymptomatically in the respiratory tract of children. To identify potential genetic differences between M. pneumoniae strains that are carried asymptomatically and those that cause symptomatic infections, we performed whole-genome sequence analysis of 20 M. pneumoniae strains. The analyzed strains included 3 reference strains, 3 strains isolated from asymptomatic children, 13 strains isolated from clinically well-defined patients suffering from an upper (n = 4) or lower (n = 9) RTI, and one strain isolated from a follow-up patient who recently recovered from an RTI...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27832195/the-clinical-and-economic-impact-of-probiotics-consumption-on-respiratory-tract-infections-projections-for-canada
#16
Irene Lenoir-Wijnkoop, Laetitia Gerlier, Denis Roy, Gregor Reid
INTRODUCTION: There is accumulating evidence supporting the use of probiotics, which are defined as "live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host", as a preventive measure against respiratory tract infections (RTI). Two recent meta-analyses showed probiotic consumption (daily intake of 107 to 1010 CFU in any form for up to 3 months) significantly reduced RTI duration, frequency, antibiotic use and work absenteeism. OBJECTIVES: The aim of this study was to assess the impact of probiotic use in terms of number of RTI episodes and days averted, and the number of antibiotic prescriptions and missed workdays averted, in the general population of Canada...
2016: PloS One
https://www.readbyqxmd.com/read/27830580/effect-of-prenatal-antioxidant-intake-on-infants-respiratory-infection-is-modified-by-a-cd14-polymorphism
#17
Seo Ah Hong, Eun Lee, Sung Ok Kwon, Kyung Won Kim, Youn Ho Shin, Kang Mo Ahn, Eun-Jin Kim, Jeom-Gyu Lee, Se-Young Oh, Soo-Jong Hong
BACKGROUND: Prenatal maternal diet may influence disease susceptibility in offspring with specific genetic backgrounds. We hypothesized that interactions between prenatal antioxidant intake and polymorphisms in immunity genes infl uence respiratory tract infection (RTI) susceptibility in infants at 12 months of age. METHODS: This study included 550 infants. In the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort study, prenatal maternal diet was assessed by administering a food frequency questionnaire...
November 3, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27815068/body-composition-and-metabolic-outcomes-after-96-weeks-of-treatment-with-ritonavir-boosted-lopinavir-plus-either-nucleoside-or-nucleotide-reverse-transcriptase-inhibitors-or-raltegravir-in-patients-with-hiv-with-virological-failure-of-a-standard-first-line
#18
Mark A Boyd, Janaki Amin, Patrick W G Mallon, Nagalingeswaran Kumarasamy, Johan Lombaard, Robin Wood, Ploenchan Chetchotisakd, Praphan Phanuphak, Lerato Mohapi, Iskandar Azwa, Waldo H Belloso, Jean-Michel Molina, Jennifer Hoy, Cecilia L Moore, Sean Emery, David A Cooper
BACKGROUND: Lipoatrophy is one of the most feared complications associated with the use of nucleoside or nucleotide reverse transcriptase inhibitors (N[t]RTIs). We aimed to assess soft-tissue changes in participants with HIV who had virological failure of a first-line antiretroviral (ART) regimen containing a non-nucleoside reverse transcriptase inhibitor plus two N(t)RTIs and were randomly assigned to receive a second-line regimen containing a boosted protease inhibitor given with either N(t)RTIs or raltegravir...
November 1, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27773779/a-closer-look-at-travellers-infections-abroad-finnish-nationwide-data-with-incidences-2010-to-2012
#19
Heli Siikamäki, Pia Kivelä, Mikael Fotopoulos, Anu Kantele
BACKGROUND: Although infections represent the most common health problem of travellers abroad, data on morbidity and incidences of various infections are scarce. METHOD: Data on infections of Finnish travellers during 2010 to 2012 were retrieved from the database of SOS International, an assistance organization covering 95% of Finns requiring aid abroad. The study included 30,086 cases. For incidence calculation, the data were linked to the numbers of Finns visiting these regions during the same period as recorded by the Official Statistics of Finland...
October 20, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27759360/a-relook-of-cefuroxime-in-community-infections-an-option-still-beneficial
#20
V R Badhwar, S Ganapathy, P P Prabhudesai, N K Tulara, A Y Varaiya, D Vyas
In community and family practice, infections are a common OPD presentation. In the management of common bacterial infections seen in community especially RTI, UTI, SSTI; cefuroxime a second generation cephalosporin with a broad spectrum of activity can be used for empirical treatment. To know current place of cefuroxime in the management of infections, physicians, surgeons, microbiologist, chest physician, gynecologist and pediatrician came together to discuss and debate their experience with cefuroxime and its place in today's world...
July 2016: Journal of the Association of Physicians of India
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