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https://www.readbyqxmd.com/read/29458037/distinguishing-keratoconic-eyes-and-healthy-eyes-using-ultrahigh-resolution-uhr-oct-based-corneal-epithelium-thickness-mapping
#1
Niklas Pircher, Florian Schwarzhans, Stephan Holzer, Jan Lammer, Doreen Schmidl, Ahmed M Bata, Renè M Werkmeister, Gerald Seidel, Gerhard Garhöfer, Andreas Gschließer, Leopold Schmetterer, Gerald Schmidinger
PURPOSE: Discovering new predictive parameters in the diagnostics of Keratoconus (KC) has high priority. Aim of this trial was to find differences in epithelial thickness (ET) maps of eyes with KC and healthy eyes. DESIGN: Institutional cross-sectional study. METHODS: In this study 40 keratoconic eyes and 76 healthy eyes were scanned using a custom-built ultrahigh resolution OCT. Automated segmentation ET-maps with 17 subsectors were calculated (central, temporal inferior, temporal superior, nasal inferior and nasal superior area)...
February 16, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29457914/estimating-road-traffic-injuries-in-jinja-district-uganda-using-the-capture-recapture-method
#2
Joseph Magoola, Olive Kobusingye, Abdulgafoor M Bachani, Nazarius Mbona Tumwesigye, Derrick Kimuli, Nino Paichadze
Road traffic injuries (RTIs) are commonly under-reported in low-and-medium-income countries. This study aimed to estimate the number of RTIs and determine the magnitude of under-reporting by traffic police and hospital registries. A two-source capture-recapture method was applied to RTI data from police and hospital registries. Seven matching variables; sex of the injured, date, place, time, day of crash and road user type were used to get the matched cases. Police independently reported 46 RTIs and the hospitals reported 206 RTIs...
February 19, 2018: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/29452770/single-arm-phase-2-trial-of-elective-nodal-dose-reduction-for-patients-with-locoregionally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#3
Patrick D Maguire, Charles R Neal, Stuart M Hardy, Andrew M Schreiber
PURPOSE: To evaluate a novel chemoradiation therapy (CRT) regimen for patients with squamous cell carcinoma of the head and neck (SCCHN) incorporating a lower intensity modulated radiation therapy dose to electively treated neck lymph nodes than is currently standard. METHODS AND MATERIALS: Eligible patients had locally advanced SCCHN of the oral cavity, oropharynx, larynx, or hypopharynx. The 7-week CRT course consisted of weekly cisplatin at 35 mg/m 2 concurrently with sequential-boost intensity modulated radiation therapy: 36 Gy to high- and low-risk planning target volumes followed by a sequential boost to the high-risk planning target volume to 70 Gy...
December 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29448344/multiple-eigenmodes-of-the-rayleigh-taylor-instability-observed-for-a-fluid-interface-with-smoothly-varying-density
#4
C X Yu, C Xue, J Liu, X Y Hu, Y Y Liu, W H Ye, L F Wang, J F Wu, Z F Fan
In this article, multiple eigen-systems including linear growth rates and eigen-functions have been discovered for the Rayleigh-Taylor instability (RTI) by numerically solving the Sturm-Liouville eigen-value problem in the case of two-dimensional plane geometry. The system called the first mode has the maximal linear growth rate and is just extensively studied in literature. Higher modes have smaller eigen-values, but possess multi-peak eigen-functions which bring on multiple pairs of vortices in the vorticity field...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29438547/effectiveness-of-general-practitioner-online-training-and-an-information-booklet-for-parents-on-antibiotic-prescribing-for-children-with-respiratory-tract-infection-in-primary-care-a-cluster-randomized-controlled-trial
#5
Anne R J Dekker, Theo J M Verheij, Berna D L Broekhuizen, Christopher C Butler, Jochen W L Cals, Nick A Francis, Paul Little, Elisabeth A M Sanders, Lucy Yardley, Nicolaas P A Zuithoff, Alike W van der Velden
Objectives: Antibiotics are too often prescribed in childhood respiratory tract infection (RTI), despite limited effectiveness, potential side effects and bacterial resistance. We aimed to reduce antibiotic prescribing for children with RTI by online training for general practitioners (GPs) and information for parents. Methods: A pragmatic cluster randomized controlled trial in primary care. The intervention consisted of online training for GPs and an information booklet for parents...
February 9, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29431136/how-patients-experiences-of-respiratory-tract-infections-affect-healthcare-seeking-and-antibiotic-use-insights-from-a-cross-sectional-survey-in-rural-anhui-china
#6
Mengjie Diao, Xingrong Shen, Jing Cheng, Jing Chai, Rui Feng, Panpan Zhang, Rongyao Zhou, Helen Lambert, Debin Wang
OBJECTIVE: To investigate the occurrence of reported respiratory tract infection (RTI) symptoms and their effects on use of self and professional care among patients in the community. DESIGN: A cross-sectional retrospective household survey. SETTING: 12 administrative villages from rural Anhui, China. PARTICIPANTS: 2160 rural adult residents aged ≥18 years registered as rural residents and actually living in the sampled villages when this study was conducted...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29416364/the-preventive-effect-on-respiratory-tract-infections-of-oscillococcinum%C3%A2-a-cost-effectiveness-analysis
#7
Giorgio L Colombo, Sergio Di Matteo, Chiara Martinotti, Martina Oselin, Giacomo M Bruno, Gianfranco M Beghi
Background: Anas barbariae hepatis et cordis extractum 200K (Oscillococcinum®) is used to treat and prevent seasonal colds and airway inflammatory affections, improve symptom control, and reduce the frequency of respiratory tract infection (RTI) episodes. The objective of this controlled observational study is to investigate, from the Italian National Health Service (NHS) point of view, the role of Anas barbariae hepatis et cordis extractum 200K in preventing RTIs and estimate the annual average cost per patient due to visits and medicines in a real-world setting, investigating whether this method of treatment can bring savings for the NHS...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29415675/teaching-children-road-safety-through-storybooks-an-approach-to-child-health-literacy-in-pakistan
#8
Haris Ahmad, Rubaba Naeem, Asher Feroze, Nukhba Zia, Amarah Shakoor, Uzma Rahim Khan, Asad Iqbal Mian
BACKGROUND: Road traffic injuries (RTIs) commonly affect the younger population in low- and-middle-income countries. School children may be educated about road safety using storybooks with colorful pictures, which tends to increase the child's interest in the text. Therefore, this study assessed the use of bilingual pictorial storybooks to improve RTI prevention knowledge among school children. METHODS: This pretest-posttest study was conducted in eight public and nine private schools of Karachi, Pakistan, between February to May 2015...
February 7, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29415609/built-environment-analysis-for-road-traffic-hotspot-locations-in-moshi-tanzania
#9
Meredith Waldon, Treasure Joelson Ibingira, Luciano de Andrade, Blandina T Mmbaga, João Ricardo N Vissoci, Mark Mvungi, Catherine A Staton
Road traffic injuries (RTIs) cause significant morbidity and mortality in low- and middle-income countries. Investigation of high risk areas for RTIs is needed to guide improvements. This study provides built environmental analysis of road traffic crash hotspots within Moshi, Tanzania. Spatial analysis of police data identified 36 hotspots. Qualitative comparative analysis revealed 40% of crash sites were on local roads without night lighting and increased motorcycle density. Paved narrow roads represented 26% of hotspots and 13% were unpaved roads with uneven roadsides...
February 8, 2018: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/29407218/membrane-cholesterol-removal-and-replenishment-affect-rat-and-monkey-brain-monoamine-transporters
#10
Marc Morissette, Nicolas Morin, Claude Rouillard, Thérèse Di Paolo
The dopamine transporter (DAT) is abundantly expressed in the striatum where it removes extracellular dopamine into the cytosol of presynaptic nerve terminals. It is the target of drugs of abuse and antidepressants. There is a loss of the DAT in Parkinson's disease affecting release of levodopa implicated in levodopa-induced dyskinesias. This study investigated the effect of cholesterol on DAT, serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2) in monkey and rat brains in vitro. DAT protein levels measured by Western blot remained unchanged with in vitro methyl-β-cyclodextrin (MCD) incubations to remove membrane cholesterol or with incubations to increase membrane cholesterol content...
January 30, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29402235/what-gives-rise-to-clinician-gut-feeling-its-influence-on-management-decisions-and-its-prognostic-value-for-children-with-rti-in-primary-care-a-prospective-cohort-study
#11
Sophie Turnbull, Patricia J Lucas, Niamh M Redmond, Hannah Christensen, Hannah Thornton, Christie Cabral, Peter S Blair, Brendan C Delaney, Matthew Thompson, Paul Little, Tim J Peters, Alastair D Hay
BACKGROUND: The objectives were to identify 1) the clinician and child characteristics associated with; 2) clinical management decisions following from, and; 3) the prognostic value of; a clinician's 'gut feeling something is wrong' for children presenting to primary care with acute cough and respiratory tract infection (RTI). METHODS: Multicentre prospective cohort study where 518 primary care clinicians across 244 general practices in England assessed 8394 children aged ≥3 months and < 16 years for acute cough and RTI...
February 5, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29383572/cognitive-function-of-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-in-a-2-year-open-label-study-of-lisdexamfetamine-dimesylate
#12
David R Coghill, Tobias Banaschewski, Caleb Bliss, Brigitte Robertson, Alessandro Zuddas
BACKGROUND: SPD489-404 was the first 2-year safety study of lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder in children and adolescents. In accordance with advice from the European Medicines Agency, assessment of cognitive function was a predefined safety outcome in SPD489-404. OBJECTIVE: The objective of this study was to assess cognitive function over 2 years in study SPD489-404, using the Cambridge Neuropsychological Test Automated Battery (CANTAB)...
January 30, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29379533/winter-ambient-training-conditions-are-associated-with-increased-bronchial-hyperreactivity-and-with-shifts-in-serum-innate-immunity-proteins-in-young-competitive-speed-skaters
#13
Marcin Kurowski, Janusz Jurczyk, Sylwia Moskwa, Marzanna Jarzębska, Hubert Krysztofiak, Marek L Kowalski
Introduction: Regular training modulates airway inflammation and modifies susceptibility to respiratory infections. The impact of exercise and ambient conditions on airway hyperreactivity and innate immunity has not been well studied. We aimed to assess exercise-related symptoms, lung function, airway hyperresponsiveness and innate immunity proteins in relation to meteorological conditions and exercise load in competitive athletes. Material and methods: Thirty-six speed skaters were assessed during winter (WTP) and summer (STP) periods...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29372085/distribution-of-trauma-care-facilities-in-oman-in-relation-to-high-incidence-road-traffic-injury-sites-pilot-study
#14
Sara M Al-Kindi, Ahmed A Naiem, Kadhim M Taqi, Najla M Al-Gheiti, Ikhtiyar S Al-Toobi, Nasra Q Al-Busaidi, Ahmed Z Al-Harthy, Alaa M Taqi, Sharif A Ba-Alawi, Hani A Al-Qadhi
Objectives: Road traffic injuries (RTIs) are considered a major public health problem worldwide. In Oman, high numbers of RTIs and RTI-related deaths are frequently registered. This study aimed to evaluate the distribution of trauma care facilities in Oman with regards to their proximity to RTI-prevalent areas. Methods: This descriptive pilot study analysed RTI data recorded in the national Royal Oman Police registry from January to December 2014. The distribution of trauma care facilities was analysed by calculating distances between areas of peak RTI incidence and the closest trauma centre using Google Earth and Google Maps software (Google Inc...
November 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29361292/child-road-traffic-injury-mortality-in-victoria-australia-0-14-years-the-need-for-targeted-action
#15
S S M Chang, R C A Symons, J Ozanne-Smith
INTRODUCTION: Extensive efforts to reduce unintentional injury were enacted in the last three decades of the 20th century. Examination of road traffic injury mortality indicates the extent of fatal, unintentional child injuries (0-14 years) future interventions must address. AIMS: (1) describe in-depth child road traffic injury (RTI) deaths 2001-2012 in Victoria, Australia (2) identify the potential preventability of the RTI causes by currently available countermeasures and scope for enhanced implementation and novel solutions...
December 21, 2017: Injury
https://www.readbyqxmd.com/read/29360277/comparative-effectiveness-of-aerosolized-versus-oral-ribavirin-for-the-treatment-of-respiratory-syncytial-virus-infections-a-single-center-retrospective-cohort-study-and-review-of-the-literature
#16
Tracy P Trang, Meghan Whalen, Alexandra Hilts-Horeczko, Sarah B Doernberg, Catherine Liu
BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of viral infections in immunocompromised hosts and is associated with significant morbidity and mortality. In January 2015, our institution switched from aerosolized to oral ribavirin (RBV) for primary treatment of RSV infection among high risk immunocompromised adult patients. The objective of the study was to evaluate the clinical and economic outcomes associated with this switch. METHODS: Retrospective cohort analysis of adult patients diagnosed with RSV infection and treated with RBV between January 1, 2013 and May 31, 2016...
January 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29349487/lay-first-responder-training-in-eastern-uganda-leveraging-transportation-infrastructure-to-build-an-effective-prehospital-emergency-care-training-program
#17
Peter G Delaney, Richard Bamuleke, Yang Jae Lee
BACKGROUND: Though road traffic injuries (RTIs) are a major cause of mortality in East Africa, few countries have emergency medical services. The aim was to create a sustainable and efficient prehospital lay first responder program, creating a system with lay first responders spread through the 53 motorcycle taxi stages of Iganga Municipality. METHODS: One hundred and fifty-four motorcycle taxi riders were taught a first aid curriculum in partnership with a local Red Cross first aid trainer and provided with a first aid kit following WHO guidelines for basic first aid...
January 18, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29347713/discrete-boltzmann-modeling-of-rayleigh-taylor-instability-in-two-component-compressible-flows
#18
Chuandong Lin, Aiguo Xu, Guangcai Zhang, Kai Hong Luo, Yingjun Li
A discrete Boltzmann model (DBM) is proposed to probe the Rayleigh-Taylor instability (RTI) in two-component compressible flows. Each species has a flexible specific-heat ratio and is described by one discrete Boltzmann equation (DBE). Independent discrete velocities are adopted for the two DBEs. The collision and force terms in the DBE account for the molecular collision and external force, respectively. Two types of force terms are exploited. In addition to recovering the modified Navier-Stokes equations in the hydrodynamic limit, the DBM has the capability of capturing detailed nonequilibrium effects...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29319521/polish-physicians-attitudes-towards-antibiotic-prescription-and-antimicrobial-resistance
#19
Beata Mazińska, Waleria Hryniewicz
Antimicrobial resistance has been one of the biggest global current issues in medicine and public health. Overuse and imprudent use of antimicrobial agents are recognized as one of the leading causes of antibiotic resistance. The aim of this study was to analyze the attitudes of Polish physicians practicing at the community level towards antibiotics and antimicrobial resistance. The majority of physicians taking part in the survey believed that Polish people overuse antibiotics (98%). Most physicians (91%) considered that antimicrobial resistance is a major problem at present...
September 27, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29305690/can-oral-ads-activity-or-arginine-levels-be-a-caries-risk-indicator-a-systematic-review-and-meta-analysis
#20
REVIEW
Mohammed Nadeem Ahmed Bijle, Cynthia Kar Yung Yiu, Manikandan Ekambaram
OBJECTIVES: The objective of this study was to evaluate the association between salivary and plaque arginine levels/ADS activities with dental caries. MATERIALS AND METHODS: A systematic search was performed as per PRISMA statement using PubMed, Scopus, Cochrane Library, and Web of Science. Published studies that investigated adults and children (P) with caries-active status (E) and caries-free status (C), whereby arginine levels/ADS activity (O) was measured in saliva/plaque to analyze exposure-outcome association compared to the control group were deemed eligible for inclusion...
January 5, 2018: Clinical Oral Investigations
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