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https://www.readbyqxmd.com/read/28649647/moonshots-and-metastatic-disease-the-need-for-a-multi-faceted-approach-when-studying-atypical-responses
#1
REVIEW
Kristine De La Torre, Elly Cohen, Anne Loeser, Marc Hurlbert
Clinical research generally focuses on results involving a statistical mean with little attention in trial design to patients who respond considerably better or worse than average. Exploring the reasons underlying an "atypical response" will increase understanding of the mechanisms involved in cancer progression and treatment resistance, accelerate biomarker identification, and improve precision medicine by allowing clinicians to prospectively select optimal treatments. Based on our review, we suggest two ways to move this field forward...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28645888/hiv-strategic-information-in-non-european-union-countries-in-the-world-health-organization-european-region-capacity-development-needs
#2
Ivana Bozicevic, Senad Handanagic, Jurja Ivana Cakalo, Annemarie Rinder Stengaard, George Rutherford
BACKGROUND: Capacity building of the national HIV strategic information system is a core component of the response to the HIV epidemic as it enables understanding of the evolving nature of the epidemic, which is critical for program planning and identification of the gaps and deficiencies in HIV programs. OBJECTIVE: The study aims to describe the results of the assessment of the needs for further development of capacities in HIV strategic information systems in the non-European Union (EU) countries in the World Health Organization European Region (EUR)...
June 23, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28645536/imaging-genetics-of-schizophrenia-in-the-post-gwas-era
#3
REVIEW
Ayla Arslan
Imaging genetics is a research methodology studying the effect of genetic variation on brain structure, function, behavior, and risk for psychopathology. Since the early 2000s, imaging genetics has been increasingly used in the research of schizophrenia (SZ). SZ is a severe mental disorder with no precise knowledge of its underlying neurobiology, however, new genetic and neurobiological data generate a climate for new avenues. The accumulating data of genome wide association studies (GWAS) continuously decode SZ risk genes...
June 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28645276/assessing-the-impact-of-health-research-on-health-policies-a-study-of-the-dodowa-health-research-centre-ghana
#4
Blanca Escribano-Ferrer, Jayne Webster, Margaret Gyapong
BACKGROUND: The importance of assessing research impact is increasingly recognised. Ghana has a long tradition of research dating from the 1970s. In the Ghana Health Service there are three health research centres under the Research and Development Division. Dodowa Health Research Centre (DHRC) is the youngest in the country dating from the 1990s. The objective of this study is to analyse the influence of the research conducted in DHRC on national and local health policies. METHODS: The study used the Research Impact Framework...
June 24, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28644694/a-bibliometric-analysis-of-highly-cited-and-high-impact-occupational-therapy-publications-by-american-authors
#5
Sharon A Gutman, Ted Brown, Yuh-Shan Ho
A bibliometric analysis was completed of peer-reviewed literature from 1991-2015, written by American occupational therapists, to examine US high impact scholarship with "occupational therapy" and "occupational therapist(s)" used as keywords to search journal articles' publication title, abstract, author details, and keywords. Results included 1,889 journal articles from 1991-2015 published by American occupational therapists as first or corresponding author. Sixty-nine articles attained a TotalCitation2015 ≥ 50 and 151 attained a Citation2015 ≥ 5 indicating that they were the most highly cited literature produced in this period...
June 23, 2017: Occupational Therapy in Health Care
https://www.readbyqxmd.com/read/28644338/committee-opinion-no-706-sexual-health
#6
(no author information available yet)
Sexuality involves a broad range of expressions of intimacy and is fundamental to self-dentification, with strong cultural, biologic, and psychologic components. Obstetrician-gynecologists often are consulted by patients about sexual health and are in a unique position to open a dialogue on sexual health issues. Several obstacles to frank conversations with patients about sexual health exist, including a lack of adequate training and confidence in the topic, a perception that there are few treatment options, a lack of adequate clinical time to obtain a sexual history, patients' reluctance to initiate the conversation, and the underestimation of the prevalence of sexual dysfunction...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28644331/committee-opinion-no-706-summary-sexual-health
#7
(no author information available yet)
Sexuality involves a broad range of expressions of intimacy and is fundamental to self-dentification, with strong cultural, biologic, and psychologic components. Obstetrician-gynecologists often are consulted by patients about sexual health and are in a unique position to open a dialogue on sexual health issues. Several obstacles to frank conversations with patients about sexual health exist, including a lack of adequate training and confidence in the topic, a perception that there are few treatment options, a lack of adequate clinical time to obtain a sexual history, patients' reluctance to initiate the conversation, and the underestimation of the prevalence of sexual dysfunction...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28643866/strategic-communication-related-to-academic-performance-evidence-from-china
#8
Li Zhao, Lulu Chen, Luwei He, Gail D Heyman
We examined a range of forms of strategic communication relevant to academic performance among 151 seventh- and eleventh-grade adolescents in China. Participants were asked to rate the frequency of their engagement of strategic communication and to evaluate the possible motives for each strategy. The most commonly adopted strategy was to give a vague response about one's own performance, and the predominant motives for strategic communication were the desires to outcompete others, to be prosocial, and to be modest...
June 23, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28643470/the-association-of-hospital-governance-with-innovation-in-taiwan
#9
Chen-Wei Yang, Yu-Hua Yan, Shih-Chieh Fang, Syeda Noorein Inamdar, Hsien-Cheng Lin
Hospitals in Taiwan are facing major changes and innovation is increasingly becoming a critical factor for remaining competitive. One determinant that can have a significant impact on innovation is hospital governance. However, there is limited prior research on the relationship between hospital governance and innovation. The purpose of this study is to propose a conceptual framework to hypothesize the relationship between governance mechanisms and innovation and to empirically test the hypotheses in hospital organizations...
June 23, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/28643090/burrow-dusting-or-oral-vaccination-prevents-plague-associated-prairie-dog-colony-collapse
#10
Daniel W Tripp, Tonie E Rocke, Jonathan P Runge, Rachel C Abbott, Michael W Miller
Plague impacts prairie dogs (Cynomys spp.), the endangered black-footed ferret (Mustela nigripes) and other sensitive wildlife species. We compared efficacy of prophylactic treatments (burrow dusting with deltamethrin or oral vaccination with recombinant "sylvatic plague vaccine" [RCN-F1/V307]) to placebo treatment in black-tailed prairie dog (C. ludovicianus) colonies. Between 2013 and 2015, we measured prairie dog apparent survival, burrow activity and flea abundance on triplicate plots ("blocks") receiving dust, vaccine or placebo treatment...
June 22, 2017: EcoHealth
https://www.readbyqxmd.com/read/28641608/hospital-based-health-technology-assessment-in-brazil-an-overview-of-the-initial-experiences
#11
Claudia Cristina de Aguiar Pereira, Renata Dos Santos Rabello, Flávia Tavares Silva Elias
OBJECTIVES: Hospital-based health technology assessment (HTA) has become increasingly important in Brazil due to its strategic importance to promote adoption, incorporation, dissemination, and disinvestment of technologies. A strategy to foster hospital-based HTA was implemented in 2009 by creating hospital-based HTA nuclei (NATS) at university hospitals and other strategic hospitals. METHODS: Between 2011 and 2012, we interviewed board members in twenty-three NATS located in all geographic regions of Brazil to assess their general characteristics, scientific output, and challenges...
June 23, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28640332/pregnant-teenagers-group-contributions-to-prenatal-care
#12
Maria Veraci Oliveira Queiroz, Giselle Maria Duarte Menezes, Thaís Jormanna Pereira Silva, Eysler Gonçalves Maia Brasil, Raimunda Magalhães da Silva
Objective: To describe changes in nurses' care following the implementation of a group of pregnant teenagers in prenatal care based on the expectations and experiences of pregnant teenagers. Method: Qualitative and descriptive study conducted from February to November 2013 at a Primary Care Unit in Fortaleza, Ceará, Brazil, through focus groups with 16 adolescents from the group of pregnant women in the second or third trimester of pregnancy. The analysis identified central ideas and units of meanings that formed the categories...
June 5, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28639548/a-leadership-perspective-on-a-shared-vision-for-healthcare
#13
Tracy Kitch
Our country's recent negotiations for a new Health Accord have shone light on the importance of more accessible and better home care. The direction being taken on health funding investments has sent a strong message about healthcare system redesign. It is time to design a healthcare system that moves us away from a hospital-focused model to one that is more effective, integrated and sustainable and one that places a greater emphasis on primary care, community care and home care. The authors of the lead paper (Sharkey and Lefebre 2017) provide their vision for people-powered care and explore the opportunity for nursing leaders to draw upon the unique expertise and insights of home care nursing as a strategic lever to bring about real health system transformation across all settings...
2017: Nursing Leadership
https://www.readbyqxmd.com/read/28639546/leadership-perspective-bringing-nursing-back-to-the-future-through-people-powered-care
#14
Shirlee Sharkey, Nancy Lefebre
At a time when there is a growing interest in person- and family-centred care and integrated community-based models, the unique strengths and expertise of home care nursing is a strategic lever for change across all healthcare settings. In this paper, we explore the theme of people-powered care as a universal starting point - a new approach to health and wellness that is anchored in the strengths of people, their networks and the patterns of everyday life. Leveraging key insights from home and community care, along with broader societal shifts towards personalization and empowerment, we discuss how nurses in all areas of the system can lead the way by empowering staff, patients and their families...
2017: Nursing Leadership
https://www.readbyqxmd.com/read/28639482/-always-looking-for-a-new-balance-toward-an-understanding-of-what-it-takes-to-continue-working-while-being-diagnosed-with-relapsing-remitting-multiple-sclerosis
#15
Hanneke van der Meide, Dennis van Gorp, Karin van der Hiele, Leo Visser
BACKGROUND: The aim of this study was to gain insight into the meaning of work in the everyday lives of people with relapsing-remitting multiple sclerosis, and the barriers and facilitators to staying in work. METHODS: Nineteen employed adults diagnosed with relapsing-remitting multiple sclerosis participated in narrative interviews. All interviews were transcribed and coded for thematic analysis. RESULTS: For people with relapsing-remitting multiple sclerosis, continuing to work was a precarious balancing act...
June 22, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28639356/bias-in-protected-area-location-and-its-effects-on-long-term-aspirations-of-biodiversity-conventions
#16
Oscar Venter, Ainhoa Magrach, Nick Outram, Carissa Joy Klein, Moreno Di Marco, James E M Watson
To contribute to the aspirations of recent international biodiversity conventions, protected areas (PAs) must be strategically located, and not simply established on economically marginal lands as they have in the past. With refined international commitments under the Convention of Biodiversity to target protected areas in places of 'importance to biodiversity', this may now be the case. Here we analyze location biases in PAs globally over both historic (pre-2004) and recent time periods. Discouragingly, we find that both old and new protected areas are not targeting places with high concentration of threatened vertebrate species...
June 21, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28639234/novel-biomarkers-of-subclinical-cardiac-dysfunction-in-the-general-population
#17
REVIEW
Kamal Shemisa, Anish Bhatt, Daniel Cheeran, Ian J Neeland
PURPOSE OF REVIEW: Recognition of subclinical myocardial dysfunction offers clinicians and patients an opportunity for early intervention and prevention of symptomatic cardiovascular disease. We review the data on novel biomarkers in subclinical heart disease in the general population with a focus on pathophysiology, recent observational or trial data, and potential applicability and pitfalls for clinical use. RECENT FINDINGS: High-sensitivity cardiac troponin and natriuretic peptide assays are powerful markers of subclinical cardiac disease...
June 21, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28639184/building-a-successful-superficial-venous-program
#18
REVIEW
Andrew Galmer, Jonathan Dunn, Maja Zaric, Joe F Lau, Mitchell Weinberg
As the treatment of superficial venous insufficiency transitioned from the hospital to the office setting, a remarkable increase in provider interest developed. However, the novelty of the disease process and procedural opportunities are tempered by the challenges associated with knowledge acquisition, skill development, strategic planning, and program development. Only a unique recipe of clinical growth, technical acumen, management skill, operational efficiency, and financial sense lead to program success...
August 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28637854/fish-prey-change-strategy-with-the-direction-of-a-threat
#19
Arjun Nair, Kelsey Changsing, William J Stewart, Matthew J McHenry
Predation is a fundamental interaction between species, yet it is unclear what escape strategies are effective for prey survival. Classical theory proposes that prey should either escape in a direction that conforms to a performance optimum or that is random and therefore unpredictable. Here, we show that larval zebrafish (Danio rerio) instead use a mixed strategy that may be either random or directed. This was determined by testing classic theory with measurements of the escape direction in response to a predator robot...
June 28, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28637744/group-clinics-for-young-adults-with-diabetes-in-an-ethnically-diverse-socioeconomically-deprived-setting-together-study-protocol-for-a-realist-review-co-design-and-mixed-methods-participatory-evaluation-of-a-new-care-model
#20
Chrysanthi Papoutsi, Dougal Hargreaves, Grainne Colligan, Ann Hagell, Anita Patel, Desirée Campbell-Richards, Russell M Viner, Shanti Vijayaraghavan, Martin Marshall, Trisha Greenhalgh, Sarah Finer
INTRODUCTION: Young adults with diabetes often report dissatisfaction with care and have poor diabetes-related health outcomes. As diabetes prevalence continues to rise, group-based care could provide a sustainable alternative to traditional one-to-one consultations, by engaging young people through life stage-, context- and culturally-sensitive approaches. In this study, we will co-design and evaluate a group-based care model for young adults with diabetes and complex health and social needs in socioeconomically deprived areas...
June 21, 2017: BMJ Open
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