keyword
https://read.qxmd.com/read/38543045/asymmetric-%C3%AE-fluoroalkyl-%C3%AE-amino-acids-recent-advances-in-their-synthesis-and-applications
#21
REVIEW
Nathan Picois, Yazid Boutahri, Pierre Milbeo, Chiara Zanato, Nathalie Lensen, Grégory Chaume, Thierry Brigaud
Due to the specific properties provided by fluorine atoms to biomolecules, amino acids with fluorinated side chains are of great interest for medicinal chemistry and chemical biology. Among them, α-fluoroalkyl-α-amino acids constitute a unique class of compounds. In this review, we outline the strategies adopted for their syntheses in enantiopure or enantioenriched forms and their incorporation into peptides. We then describe the consequences of the introduction of fluorine atoms in these compounds for the modulation of their hydrophobicity and the control of their conformation...
March 21, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38543042/design-synthesis-and-biological-evaluation-of-novel-coumarin-analogs-targeted-against-sars-cov-2
#22
JOURNAL ARTICLE
Kirti Sharma, Manjinder Singh, Pratibha Sharma, Sumesh C Sharma, Somdutt Mujwar, Mohit Kapoor, Krishna Kumar Mishra, Tanveer A Wani
SARS-CoV, an RNA virus, is contagious and displays a remarkable degree of adaptability, resulting in intricate disease presentations marked by frequent genetic mutations that can ultimately give rise to drug resistance. Targeting its viral replication cycle could be a potential therapeutic option to counter its viral growth in the human body leading to the severe infectious stage. The Mpro of SARS-CoV-2 is a promising target for therapeutic development as it is crucial for viral transcription and replication...
March 21, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542922/structure-synthesis-and-catalytic-performance-of-emerging-mxene-based-catalysts
#23
REVIEW
Zhengxiang Sun, Rui Wang, Vitaly Edwardovich Matulis, Korchak Vladimir
As traditional fossil fuel energy development faces significant challenges, two-dimensional layered materials have become increasingly popular in various fields and have generated widespread research interest. MXene is an exceptional catalytic material that is typically integrated into functional composite materials with other substances to enhance its catalytic-reaction performance. Improving the thermal stability, electrical conductivity, and electrochemical activity, as well as enhancing the specific surface structure, can make the material an excellent catalyst for photoelectrocatalysis and energy-regeneration reactions...
March 14, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542453/advances-in-the-study-of-extracellular-vesicles-for-bone-regeneration
#24
REVIEW
Yao Jiao, Yitong Liu, Juan Du, Junji Xu, Zhenhua Luo, Yi Liu, Lijia Guo
Promoting the efficiency of bone regeneration in bone loss diseases is a significant clinical challenge. Traditional therapies often fail to achieve better therapeutic outcomes and shorter treatment times. However, in recent years, extracellular vesicles (EVs) have gained significant attention due to their exceptional osteogenic function in bone regeneration and superior therapeutic effects compared to traditional cell therapy. EVs have emerged as a promising therapy for tissue defect regeneration due to their various physiological functions, such as regulating the immune response and promoting tissue repair and regeneration...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542303/antibacterial-properties-of-rose-bengal-conjugated-to-hyaluronic-acid
#25
JOURNAL ARTICLE
Melad Atrash, Iryna Hovor, Yanna Gurianov, Margarita Barel, Olga Semenova, Tamara Brider, Marina Nisnevitch, Faina Nakonechny
Dental diseases, including conditions affecting oral structures, have become more common due to unhealthy lifestyle choices. Traditional antibiotic treatments face challenges related to the development of antibiotic resistance in bacteria. Photodynamic antibacterial chemotherapy is emerging as a promising alternative using photosensitizers to generate reactive oxygen species upon exposure to light. This article examines the photosensitizer Rose Bengal (RB) immobilized in hyaluronic acid (HA) for prolonged antibacterial action...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542268/cutting-edge-hek293t-protein-integrated-lipid-nanostructures-boosting-biocompatibility-and-efficacy
#26
JOURNAL ARTICLE
Jung-Hyun Park, Cheng-Zhe Bai, Jeong-Hun Kwak, Ho-Joong Choi, Dosang Lee, Ha-Eun Hong, Ok-Hee Kim, Say-June Kim
Recently, artificial exosomes have been developed to overcome the challenges of natural exosomes, such as production scalability and stability. In the production of artificial exosomes, the incorporation of membrane proteins into lipid nanostructures is emerging as a notable approach for enhancing biocompatibility and treatment efficacy. This study focuses on incorporating HEK293T cell-derived membrane proteins into liposomes to create membrane-protein-bound liposomes (MPLCs), with the goal of improving their effectiveness as anticancer therapeutics...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542189/silica-microparticles-from-sugarcane-by-products-as-an-encapsulation-system-for-retinoids-aimed-at-topical-sustained-release
#27
JOURNAL ARTICLE
Joana R Costa, Ana Helena Costa, João Azevedo-Silva, Diana Tavares-Valente, Sérgio C Sousa, Tânia Neto, Manuela E Pintado, Ana Raquel Madureira
The encapsulation of retinol within silica microparticles has emerged as a promising opportunity in the realm of cosmetic and pharmaceutical formulations, driven by the need to reinforce the photoprotection and oxidation stability of retinol. This work examines the process of encapsulating retinol into silica microparticles. The association efficiency, microparticle size, molecular structure, morphology, oxidation, and release profile, as well as biocompatibility and skin sensitization, were evaluated. Results showed that 0...
March 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542156/in-vitro-cross-linking-ms-reveals-smg1-upf2-smg7-assembly-as-molecular-partners-within-the-nmd-surveillance
#28
JOURNAL ARTICLE
Monikaben Padariya, Borivoj Vojtesek, Ted Hupp, Umesh Kalathiya
mRNAs containing premature stop codons are responsible for various genetic diseases as well as cancers. The truncated proteins synthesized from these aberrant mRNAs are seldom detected due to the nonsense-mediated mRNA decay (NMD) pathway. Such a surveillance mechanism detects most of these aberrant mRNAs and rapidly destroys them from the pool of mRNAs. Here, we implemented chemical cross-linking mass spectrometry (CLMS) techniques to trace novel biology consisting of protein-protein interactions (PPIs) within the NMD machinery...
March 10, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541788/robotic-assisted-epicardial-hybrid-ablation-and-left-appendage-closure-in-persistent-atrial-fibrillation-first-european-experience
#29
JOURNAL ARTICLE
Alfonso Agnino, Laura Giroletti, Ascanio Graniero, Piersilvio Gerometta, Matteo Parrinello, Giovanni Albano, Eduardo Celentano, Ernesto Cristiano, Giuseppe Nasso, Natasja M S de Groot
Background: Pulmonary vein isolation is currently considered to be the gold standard for ablating paroxysmal atrial fibrillation. However, its efficacy is limited in patients with persistent atrial fibrillation. The convergent procedure has emerged as a hybrid ablation. This study aims, for the first time in the literature, to introduce a hybrid approach that includes epicardial ablation with cutting-edge robotic technology and subsequent electrophysiological study to verify and an endocardial ablation to complete the ablation lines...
March 8, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541739/could-life-have-started-on-mars-planetary-conditions-that-assemble-and-destroy-protocells
#30
JOURNAL ARTICLE
Francesca C A Cary, David W Deamer, Bruce F Damer, Sarah A Fagents, Kathleen C Ruttenberg, Stuart P Donachie
Early Mars was likely habitable, but could life actually have started there? While cellular life emerged from prebiotic chemistry through a pre-Darwinian selection process relevant to both Earth and Mars, each planet posed unique selection 'hurdles' to this process. We focus on drivers of selection in prebiotic chemistry generic to Earth-like worlds and specific to Mars, such as an iron-rich surface. Iron, calcium, and magnesium cations are abundant in hydrothermal settings on Earth and Mars, a promising environment for an origin of life...
March 20, 2024: Life
https://read.qxmd.com/read/38541104/the-evolution-of-lateral-lumbar-interbody-fusion-a-journey-from-past-to-present
#31
REVIEW
Anthony Xi Jie Wong, Derek Haowen Tang, Arun-Kumar Kaliya-Perumal, Jacob Yoong-Leong Oh
Lumbar interbody fusion procedures have seen a significant evolution over the years, with various approaches being developed to address spinal pathologies and instability, including posterior lumbar interbody fusion (PLIF), transforaminal lumbar interbody fusion (TLIF), anterior lumbar interbody fusion (ALIF), and lateral lumbar interbody fusion (LLIF). LLIF, a pivotal technique in the field, initially emerged as extreme/direct lateral interbody fusion (XLIF/DLIF) before the development of oblique lumbar interbody fusion (OLIF)...
February 23, 2024: Medicina
https://read.qxmd.com/read/38541036/exceptional-cases-demand-exceptional-personalized-solutions-the-next-level-in-dental-rehabilitation
#32
JOURNAL ARTICLE
Nils-Claudius Gellrich, Philippe Korn, Philipp Jehn, Michael Neuhaus, Fritjof Lentge, Björn Rahlf
Defects and bone loss in the maxilla and mandible pose significant challenges for dental rehabilitation. This paper focuses on complex cases of bimaxillary dental rehabilitation, where traditional dental implant protocols were not feasible in at least one jaw. Four patients were examined conceptually, where conventional dental implant placement (n = 20) was combined in either the same or opposite jaw with a patient-specific subperiosteal implant (n = 5). This study evaluates aspects such as primary stability, prosthodontic restoration, complications, and soft tissue management over the observation period...
March 9, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38541035/cardiac-arrest-and-complete-heart-block-complications-after-electrical-cardioversion-for-unstable-supraventricular-tachycardia-in-the-emergency-department
#33
Adina Maria Marza, Claudiu Barsac, Dumitru Sutoi, Alexandru Cristian Cindrea, Alexandra Herlo, Cosmin Iosif Trebuian, Alina Petrica
Synchronous electrical cardioversion is a relatively common procedure in the emergency department (ED), often performed for unstable supraventricular tachycardia (SVT) or unstable ventricular tachycardia (VT). However, it is also used for stable cases resistant to drug therapy, which carries a risk of deterioration. In addition to the inherent risks linked with procedural sedation, there is a possibility of malignant arrhythmias or bradycardia, which could potentially result in cardiac arrest following this procedure...
March 9, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540698/extracellular-vesicles-as-delivery-vehicles-for-non-coding-rnas-potential-biomarkers-for-chronic-liver-diseases
#34
REVIEW
Arianna Ferro, Gabriele Saccu, Simone Mattivi, Andrea Gaido, Maria Beatriz Herrera Sanchez, Shafiul Haque, Lorenzo Silengo, Fiorella Altruda, Marilena Durazzo, Sharmila Fagoonee
In recent years, EVs have emerged as promising vehicles for coding and non-coding RNAs (ncRNAs), which have demonstrated remarkable potential as biomarkers for various diseases, including chronic liver diseases (CLDs). EVs are small, membrane-bound particles released by cells, carrying an arsenal of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and other ncRNA species, such as piRNAs, circRNAs, and tsRNAs. These ncRNAs act as key regulators of gene expression, splicing, and translation, providing a comprehensive molecular snapshot of the cells of origin...
February 26, 2024: Biomolecules
https://read.qxmd.com/read/38540600/impact-of-the-covid-19-pandemic-on-therapy-and-outcome-of-acute-exacerbations-of-chronic-obstructive-lung-disease-at-the-emergency-department
#35
JOURNAL ARTICLE
Verena Fuhrmann, Bettina Wandl, Anton N Laggner, Dominik Roth
This study compared the treatment outcomes of acute exacerbation of COPD (AECOPD) at an academic tertiary care emergency department before and during the COVID-19 pandemic. Analyzing data from 976 patients, our study showed a significant surge in overall respiratory therapy interventions amidst the noticeable decline in the total number of AECOPD cases during the pandemic. The marked increase in the utilization of non-invasive ventilation (NIV) was particularly important, soaring from 12% to 18% during the pandemic...
March 12, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38540589/evaluating-machine-learning-stability-in-predicting-depression-and-anxiety-amidst-subjective-response-errors
#36
JOURNAL ARTICLE
Wai Lim Ku, Hua Min
Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) pose significant burdens on individuals and society, necessitating accurate prediction methods. Machine learning (ML) algorithms utilizing electronic health records and survey data offer promising tools for forecasting these conditions. However, potential bias and inaccuracies inherent in subjective survey responses can undermine the precision of such predictions. This research investigates the reliability of five prominent ML algorithms-a Convolutional Neural Network (CNN), Random Forest, XGBoost, Logistic Regression, and Naive Bayes-in predicting MDD and GAD...
March 10, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38540111/differential-role-of-factor-xiii-in-acute-myocardial-infarction-and-ischemic-stroke
#37
REVIEW
Jan Traub, Martin S Weber, Anna Frey
Factor XIII is a transglutaminase enzyme that plays a crucial role in hemostasis and wound healing. It crosslinks fibrin strands, stabilizing clots and promoting clot resistance to fibrinolysis. Additionally, Factor XIII has been found to have multiple other functions that extend beyond coagulation, including the regulation of inflammation and tissue repair processes. Emerging evidence suggests that Factor XIII may also have differential roles in acute myocardial infarction and ischemic stroke, two common cardiovascular events with significant morbidity and mortality...
February 22, 2024: Biomedicines
https://read.qxmd.com/read/38540104/the-gastric-cancer-immune-prognostic-score-gcips-shows-potential-in-predicting-an-unfavorable-prognosis-for-gastric-cancer-patients-undergoing-immune-checkpoint-inhibitor-treatment
#38
JOURNAL ARTICLE
Yanjiao Zuo, Hao Sun, Hongming Pan, Ruihu Zhao, Yingwei Xue, Hongjiang Song
(1) Background: This study aims to explore the predictive capability of the Gastric Cancer Immune Prognostic Score (GCIPS) for an unfavorable prognosis in gastric cancer patients undergoing immune checkpoint inhibitor (ICI) treatment. (2) Methods: This study included 302 gastric cancer patients who underwent treatment with ICIs at our institution from January 2017 to December 2022. The patients were randomly divided into a test set (201 cases) and a validation set (101 cases) using a random number table. Kaplan-Meier survival analysis and the log-rank test were used to investigate survival differences...
February 22, 2024: Biomedicines
https://read.qxmd.com/read/38539786/weak-scale-supersymmetry-emergent-from-the-string-landscape
#39
JOURNAL ARTICLE
Howard Baer, Vernon Barger, Dakotah Martinez, Shadman Salam
Superstring flux compactifications can stabilize all moduli while leading to an enormous number of vacua solutions, each leading to different 4-d laws of physics. While the string landscape provides at present the only plausible explanation for the size of the cosmological constant, it may also predict the form of weak scale supersymmetry which is expected to emerge. Rather general arguments suggest a power-law draw to large soft terms, but these are subject to an anthropic selection of a not-too-large value for the weak scale...
March 21, 2024: Entropy
https://read.qxmd.com/read/38538995/green-synthesis-of-solketal-from-glycerol-using-metal-modified-zsm-5-zeolite-catalysts-process-optimization
#40
JOURNAL ARTICLE
Jamna Prasad Gujar, Bharat Modhera
This study investigates the production of solketal (2,2-dimethyl-1,3-dioxolane-4-methanol) from glycerol via ketalization reaction using M-ZSM-5 catalysts (M = Fe, Co, Ni, Cu, and Zn). The wet impregnation method ensured precise metal loading and versatility in catalyst preparation. We present a novel approach by employing a suite of characterization techniques, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), Thermogravimetric analysis (TGA), and Field-emission scanning electron microscopy (FE-SEM), to elucidate the catalyst's structure, bonding, surface area, thermal stability, and morphology, ultimately linking these properties to their performance...
March 27, 2024: Environmental Science and Pollution Research International
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