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https://www.readbyqxmd.com/read/28092688/buckled-two-dimensional-xene-sheets
#1
Alessandro Molle, Joshua Goldberger, Michel Houssa, Yong Xu, Shou-Cheng Zhang, Deji Akinwande
Silicene, germanene and stanene are part of a monoelemental class of two-dimensional (2D) crystals termed 2D-Xenes (X = Si, Ge, Sn and so on) which, together with their ligand-functionalized derivatives referred to as Xanes, are comprised of group IVA atoms arranged in a honeycomb lattice - similar to graphene but with varying degrees of buckling. Their electronic structure ranges from trivial insulators, to semiconductors with tunable gaps, to semi-metallic, depending on the substrate, chemical functionalization and strain...
January 16, 2017: Nature Materials
https://www.readbyqxmd.com/read/28092499/nanoparticles-for-sirna-based-gene-silencing-in-tumor-therapy
#2
Anish Babu, Ranganayaki Muralidharan, Narsireddy Amreddy, Meghna Mehta, Anupama Munshi, Rajagopal Ramesh
Gene silencing through RNA interference (RNAi) has emerged as a potential strategy in manipulating cancer causing genes by complementary base-pairing mechanism. Small interfering RNA (siRNA) is an important RNAi tool that has found significant application in cancer therapy. However due to lack of stability, poor cellular uptake and high probability of loss-of-function due to degradation, siRNA therapeutic strategies seek safe and efficient delivery vehicles for in vivo applications. The current review discusses various nanoparticle systems currently used for siRNA delivery for cancer therapy, with emphasis on liposome based gene delivery systems...
December 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28089848/sparc-preserves-follicular-epithelium-integrity-in-insect-ovaries
#3
Paula Irles, Saray Ramos, Maria-Dolors Piulachs
The importance of juvenile hormone regulating insect oogenesis suggests looking for genes whose expression is regulated by this hormone. SPARC is a calcium-binding glycoprotein that forms part of the extracellular membranes, which in vertebrates participates in bones mineralization or regulating cell proliferation in some cancer types. This large number of functions described for SPARC in different species might be related to the significant differences in its structure observed when comparing different species-groups...
January 12, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28088784/a-phase-i-clinical-study-of-autologous-dendritic-cell-therapy-in-patients-with-relapsed-or-refractory-multiple-myeloma
#4
Sung-Hoon Jung, Hyun-Ju Lee, Youn-Kyung Lee, Deok-Hwan Yang, Hyeoung-Joon Kim, Joon Haeng Rhee, Frank Emmrich, Je-Jung Lee
Cellular immunotherapy is emerging as a potential immunotherapeutic modality in multiple myeloma (MM). We have developed potent immunotherapeutic agent (VAX-DC/MM) generated by dendritic cells (DCs) loaded with autologous myeloma cells irradiated with ultraviolet B. In this study, we evaluated the safety and efficacy of VAX-DC/MM in patients with relapsed or refractory MM. This trial enrolled relapsed or refractory MM patients who had received both thalidomide- and bortezomib-based therapies. Patients received the intradermal VAX-DC/MM injection every week for 4 weeks...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28088691/stability-effect-of-cholesterol-poly-acrylic-acid-in-a-stimuli-responsive-polymer-liposome-complex-obtained-from-soybean-lecithin-for-controlled-drug-delivery
#5
M G Simões, P Alves, Manuela Carvalheiro, P N Simões
The development of polymer-liposome complexes (PLCs), in particular for biomedical applications, has grown significantly in the last decades. The importance of these studies comes from the emerging need in finding intelligent controlled release systems, more predictable, effective and selective, for applications in several areas, such as treatment and/or diagnosis of cancer, neurological, dermatological, ophthalmic and orthopedic diseases, gene therapy, cosmetic treatments, and food engineering. This work reports the development and characterization of a pH sensitive system for controlled release based on PLCs...
January 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28088566/removal-of-salicylic-acid-as-an-emerging-contaminant-by-a-polar-nano-dendritic-adsorbent-from-aqueous-media
#6
M Arshadi, F Mousavinia, M K Abdolmaleki, M J Amiri, A Khalafi-Nezhad
A polar nano-dendritic adsorbent containing amine groups (SAPAMAA) was synthesized onto the nanoparticles of SiO2Al2O3 and its uptake of salicylic acid (SA) from the synthetic and real water was investigated. The synthesized nanomaterials were fully studied by nuclear magnetic resonance spectrum ((1)H NMR and (13)C NMR), Fourier transform infrared spectroscopy (FT-IR), zeta potential (ζ), inductively coupled plasma atomic emission spectroscopy (ICP-AES), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) and elemental analysis...
January 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28087407/polymeric-micelles-for-ocular-drug-delivery-from-structural-frameworks-to-recent-preclinical-studies
#7
REVIEW
Abhirup Mandal, Rohit Bisht, Ilva D Rupenthal, Ashim K Mitra
Effective intraocular drug delivery poses a major challenge due to the presence of various elimination mechanisms and physiological barriers that result in low ocular bioavailability after topical application. Over the past decades, polymeric micelles have emerged as one of the most promising drug delivery platforms for the management of ocular diseases affecting the anterior (dry eye syndrome) and posterior (age-related macular degeneration, diabetic retinopathy and glaucoma) segments of the eye. Promising preclinical efficacy results from both in-vitro and in-vivo animal studies have led to their steady progression through clinical trials...
January 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28087173/at-the-heart-of-the-problem-a-person-centred-developmental-perspective-on-the-link-between-alcohol-consumption-and-cardio-vascular-events
#8
Valéria Lima Passos, Sven Klijn, Kevin van Zandvoort, Latifa Abidi, Paul Lemmens
INTRODUCTION: The cardio-protective effect of alcohol has been the subject of a long-standing scientific controversy. Emerging evidence remains equivocal, as the validity of the dose-dependent J-shape association is tainted by conceptual, theoretical and methodological problems. A major impediment for a resolution on the matter is the lack of a life-long developmental approach to pinpoint alcohol's specific impact on the risk for cardio-vascular events (CVE). OBJECTIVE: Using retrospective and prospective individual-level data of alcohol consumption (AC) we applied a model-based clustering technique to uncover life-course trajectories of AC and explored their links to CVE...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28080027/asymmetric-pentagonal-metal-meshes-for-flexible-transparent-electrodes-and-heaters
#9
Daniel Lordan, Micheal Burke, Mary Manning, Alfonso Martin, Andreas Amann, Dan O' Connell, Richard Murphy, Colin Lyons, Aidan J Quinn
Metal meshes have emerged as an important class of flexible transparent electrodes. We report on the characteristics of a new class of asymmetric meshes, tiled using a recently-discovered family of pentagons. Micron-scale meshes were fabricated on flexible polyethylene terephthalate substrates via optical lithography, metal evaporation (Ti 10 nm, Pt 50 nm) and lift-off. Three different designs were assessed, each with the same tessellation pattern and linewidth (5 µm), but with different sizes of the fundamental pentagonal unit...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28079906/4d-and-5d-bimetal-doped-tubular-silicon-clusters-si12m2-with-m-nb-ta-mo-and-w-a-bimetallic-configuration-model
#10
Hung Tan Pham, Devashis Majumdar, Jerzy Leszczynski, Minh Tho Nguyen
Geometries and electronic properties related to the ground state stabilities of several Si12M2 clusters (M: second-row (Nb and Mo) and third-row (Ta and W) transition metals, and their mixed bimetallic clusters M2: NbMo and TaW) were explored using density functional theory (DFT) computations. The computed results show that two different structural motifs emerge as the global energy minima of such clusters. They are basically singlet tubular structures in either a C2v prism ((1)A1) or a C6v antiprism ((1)A1) form...
January 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28079255/moonlighting-at-replication-forks-a-new-life-for-homologous-recombination-proteins-brca1-brca2-and-rad51
#11
REVIEW
Arun Mouli Kolinjivadi, Vincenzo Sannino, Anna de Antoni, Hervé Técher, Giorgio Baldi, Vincenzo Costanzo
Coordination between DNA replication and DNA repair ensures maintenance of genome integrity, which is lost in cancer cells. Emerging evidence has linked Homologous Recombination (HR) proteins RAD51, BRCA1 and BRCA2 to the stability of nascent DNA. This function appears to be distinct from Double Strand Break (DSB) repair and is in part due to the prevention of MRE11-mediated degradation of nascent DNA at stalled forks. The role of RAD51 in fork protection resembles the activity described for its prokaryotic ortholog RecA, which prevents nuclease-mediated degradation of DNA and promotes replication fork restart in cells challenged by DNA damaging agents...
January 12, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28078473/traumatic-atlantoaxial-rotatory-fixation-in-an-adult-patient
#12
María A García-Pallero, Cristina V Torres, Juan Delgado-Fernández, R G Sola
INTRODUCTION: Atlantoaxial rotational fixation (AARF) is a rare entity in adults, with only a few cases reported in the English literature and often associated with a traumatic mechanism. It is an underdiagnosed condition that must be taken into account in the initial assessment of all craniocervical trauma. Both diagnostic and therapeutic delay may be a potential cause of severe neurological damage or even death of the patient. The therapeutic management is controversial given the difficulty of achieving optimum stability and permanent reduction...
January 11, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28077662/stability-and-plasticity-in-neural-encoding-of-linguistically-relevant-pitch-patterns
#13
Zilong Xie, Rachel Denise Reetzke, Bharath Chandrasekaran
While life-long language experience modulates subcortical encoding of pitch patterns, there is emerging evidence that short-term training introduced in adulthood also shapes subcortical pitch encoding. Here, we use a cross-language design to examine the stability of language experience-dependent subcortical plasticity over multiple days. We then examine the extent to which behavioral relevance induced by speech sound-to-category training leads to plastic changes in subcortical pitch encoding in adulthood relative to adolescence, a period of ongoing maturation of subcortical and cortical auditory processing...
January 11, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28074359/pharmacological-management-of-chronic-pelvic-pain-in-women
#14
REVIEW
Erin T Carey, Sara R Till, Sawsan As-Sanie
Chronic pelvic pain (CPP) is a multifaceted condition that often has both peripheral and central generators of pain. An understanding of neurobiology and neuropsychology of CPP should guide management. Successful treatment of CPP is typically multimodal, and pharmacologic treatment strategies include analgesics, hormonal suppression, anesthetics, antidepressants, membrane stabilizers, and anxiolytics. Evidence for these and other emerging pharmacologic therapies is presented in this article.
January 10, 2017: Drugs
https://www.readbyqxmd.com/read/28073472/the-interaction-between-cyanobacteria-and-zooplankton-in-a-more-eutrophic-world
#15
REVIEW
Kemal Ali Ger, Pablo Urrutia-Cordero, Paul C Frost, Lars-Anders Hansson, Orlando Sarnelle, Alan E Wilson, Miquel Lürling
As blooms of cyanobacteria expand and intensify in freshwater systems globally, there is increasing interest in their ecological effects. In addition to being public health hazards, cyanobacteria have long been considered a poor quality food for key zooplankton grazers that link phytoplankton to higher trophic levels. While past laboratory studies have found negative effects of nutritional constraints and defensive traits (i.e., toxicity and colonial or filamentous morphology) on the fitness of large generalist grazers (i...
April 2016: Harmful Algae
https://www.readbyqxmd.com/read/28072695/acute-pulmonary-edema-caused-by-takotsubo-cardiomyopathy-in-a-pregnant-woman-undergoing-transvaginal-cervical-cerclage-a-case-report
#16
Jae-Young Lee, Hyun-Jung Kwon, Sang-Wook Park, Yu-Mi Lee
BACKGROUND: The physiological changes associated with pregnancy may predispose pregnant women to pulmonary edema. Other known causes of pulmonary edema during pregnancy include tocolytic drugs, preeclampsia, eclampsia, and peripartum cardiomyopathy. METHODS: We describe a rare case of pulmonary edema caused by takotsubo cardiomyopathy in a pregnant woman at 14 weeks of gestation who was undergoing emergency transvaginal cervical cerclage. RESULTS: Intraoperative chest radiography revealed severe pulmonary edema and echocardiography indicated moderate left ventricular dysfunction with akinesia of the mid to apical left ventricular wall segment, which is reflective of takotsubo cardiomyopathy...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28071650/improved-ethanol-electrooxidation-performance-by-shortening-pd-ni-active-site-distance-in-pd-ni-p-nanocatalysts
#17
Lin Chen, Lilin Lu, Hengli Zhu, Yueguang Chen, Yu Huang, Yadong Li, Leyu Wang
Incorporating oxophilic metals into noble metal-based catalysts represents an emerging strategy to improve the catalytic performance of electrocatalysts in fuel cells. However, effects of the distance between the noble metal and oxophilic metal active sites on the catalytic performance have rarely been investigated. Herein, we report on ultrasmall (∼5 nm) Pd-Ni-P ternary nanoparticles for ethanol electrooxidation. The activity is improved up to 4.95 A per mgPd, which is 6.88 times higher than commercial Pd/C (0...
January 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28070555/molecular-ligand-modulation-of-palladium-nanocatalysts-for-highly-efficient-and-robust-heterogeneous-oxidation-of-cyclohexenone-to-phenol
#18
Teng Xue, Zhaoyang Lin, Chin-Yi Chiu, Yongjia Li, Lingyan Ruan, Gongming Wang, Zipeng Zhao, Chain Lee, Xiangfeng Duan, Yu Huang
Metallic nanoparticles are emerging as an exciting class of heterogeneous catalysts with the potential advantages of exceptional activity, stability, recyclability, and easier separation than homogeneous catalysts. The traditional colloid nanoparticle syntheses usually involve strong surface binding ligands that could passivate the surface active sites and result in poor catalytic activity. The subsequent removal of surface ligands could reactivate the surface but often leads to metal ion leaching and/or severe Ostwald ripening with diminished catalytic activity or poor stability...
January 2017: Science Advances
https://www.readbyqxmd.com/read/28069418/splenic-artery-aneurysm-rupture-in-pregnancy
#19
Joshua Jacobson, Chad Gorbatkin, Stacey Good, Scott Sullivan
CASE PRESENTATION: A pregnant woman at 22+5/7weeks gestation presented to the emergency department (ED) from an outpatient clinic, hypotensive after experiencing a syncopal episode. On arrival to the ER she was tachycardic, tachypneic and complaining of abdominal pain. A bedside FAST was performed and noted free fluid in the abdomen. Subsequent CT obtained noted the rare but life-threatening diagnosis of ruptured splenic artery aneurysm that resulted in emergent transfer to the operating room with OB/GYN and general surgery...
December 15, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28069236/recent-advancements-in-the-sonophotocatalysis-spc-and-doped-sonophotocatalysis-dspc-for-the-treatment-of-recalcitrant-hazardous-organic-water-pollutants
#20
REVIEW
Debabrata Panda, Sivakumar Manickam
: Sonophotocatalysis (SPC) is considered to be one of the important wastewater treatment techniques and hence attracted the attention of researchers to eliminate recalcitrant hazardous organic pollutants from aqueous phase. In general, SPC refers to the integrated use of ultrasonic sound waves, ultraviolet radiation and the addition of a semiconductor material which functions as a photocatalyst. Current research has brought numerous improvements in the SPC based treatment by opting visible light irradiation, nanocomposite catalysts and numerous catalyst supports for better stability and performance...
May 2017: Ultrasonics Sonochemistry
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