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https://www.readbyqxmd.com/read/28749599/heat-induced-inflammation-and-its-role-in-esophageal-cancer
#1
REVIEW
Mohaddese Maghsudlu, Ehsan Farashahi Yazd
Esophageal cancer as the sixth common cause of cancer death in the world consists of different histological types with various incidence patterns. Among them, esophageal adenocarcinoma and esophageal squamous cell carcinoma are the most prevalent types which also have different causality, cell of origin and risk factors. Since epidemiological studies have announced consumption of hot substances as one of the major risk factors for squamous cell carcinoma, evaluating the effect of this external stress on esophagus cells seems desirable...
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28747773/deciphering-mechanisms-of-acquired-t790m-mutation-after-egfr-inhibitors-for-nsclc-by-computational-simulations
#2
Bin Zou, Victor H F Lee, Lijiang Chen, Lichun Ma, Debby D Wang, Hong Yan
Metastatic non-small-cell lung cancer (NSCLC) with activating EGFR mutations responds very well to first and second generation tyrosine-kinase inhibitors (TKI) including gefitinib, erlotinib and afatinib. Unfortunately, drug resistance will eventually develop and about half of the cases are secondary to the emergence of acquired T790M somatic mutation. In this work, we prospectively recruited 68 patients with metastatic EGFR-mutated NSCLC who have developed progressive disease after first-line TKI with or without subsequent TKI and/or other systemic therapy...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747680/glycoengineering-of-epha4-fc-leads-to-a-unique-long-acting-and-broad-spectrum-eph-receptor-therapeutic-antagonist
#3
Cassandra L Pegg, Leanne T Cooper, Jing Zhao, Michael Gerometta, Fiona M Smith, Michael Yeh, Perry F Bartlett, Jeffrey J Gorman, Andrew W Boyd
Eph receptors have emerged as targets for therapy in both neoplastic and non-neoplastic disease, however, particularly in non-neoplastic diseases, redundancy of function limits the effectiveness of targeting individual Eph proteins. We have shown previously that a soluble fusion protein, where the EphA4 ectodomain was fused to IgG Fc (EphA4 Fc), was an effective therapy in acute injuries and demonstrated that EphA4 Fc was a broad spectrum Eph/ephrin antagonist. However, a very short in vivo half-life effectively limited its therapeutic development...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747544/activation-of-cancerous-inhibitor-of-pp2a-cip2a-contributes-to-lapatinib-resistance-through-induction-of-cip2a-akt-feedback-loop-in-erbb2-positive-breast-cancer-cells
#4
Ming Zhao, Erin W Howard, Amanda B Parris, Zhiying Guo, Qingxia Zhao, Zhikun Ma, Ying Xing, Bolin Liu, Susan M Edgerton, Ann D Thor, Xiaohe Yang
Lapatinib, a small molecule ErbB2/EGFR inhibitor, is FDA-approved for the treatment of metastatic ErbB2-overexpressing breast cancer; however, lapatinib resistance is an emerging clinical challenge. Understanding the molecular mechanisms of lapatinib-mediated anti-cancer activities and identifying relevant resistance factors are of pivotal significance. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified oncoprotein that is overexpressed in breast cancer. Our study investigated the role of CIP2A in the anti-cancer efficacy of lapatinib in ErbB2-overexpressing breast cancer cells...
July 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28745885/chemical-synthesis-demonstrates-dynamic-o-glycosylation-regulates-folding-and-functional-conformation-of-a-pivotal-egf12-domain-of-human-notch1-receptor
#5
Shun Hayakawa, Yasuhiro Yokoi, Hiroshi Hinou, Shin-Ichiro Nishimura
The interaction of human NOTCH1 receptor and its ligands is a crucial step to initiate the intracellular signal transductions, in which O-glycosylation of the extracellular EGF-like domain is known to modify this pathway that strongly affects multiple aspects of cell differentiation, development, and cancer biology. In spite of the emerging importance of O-glycosylation in the NOTCH signaling pathway, consequences of this dynamic O-glycosylation processes in ER/Golgi on the folding of functional EGF-like domains re-main unclear...
July 26, 2017: Biochemistry
https://www.readbyqxmd.com/read/28745857/altered-level-of-consciousness-evidence-based-management-in-the-emergency-department-digest
#6
Joo Lee Song, Vincent J Wang, Michelle N Vazquez
A child who presents to the emergency department with an altered level of consciousness can be clinically unstable and can pose a great diagnostic challenge. The emergency clinician must quickly develop a wide differential of possible etiologies in order to administer potentially life-saving medications or interventions. The history, physical examination, and appropriate diagnostic tests can aid greatly in rapidly narrowing the differential diagnosis. Once initial stabilization, workup, and first-line interventions are completed, most patients who present with unresolved or unidentified altered level of consciousness should be admitted for further evaluation and close monitoring...
January 22, 2017: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/28745363/novel-nanosensing-technologies-for-exosome-detection-and-profiling
#7
REVIEW
Hyungsoon Im, Kyungheon Lee, Ralph Weissleder, Hakho Lee, Cesar M Castro
Exosomes have recently emerged as highly promising cancer biomarkers because they are abundant in biofluids, carry proteins and RNA reflecting their originating cells and are stable over weeks. Beyond abundance and stability, detailed exosome analyses could be clinically useful for diagnosing and profiling cancers. Despite their clinical potential, simple, reliable and sensitive approaches for rapidly quantifying exosomes and their molecular information has been challenging. Therefore, there is a clear need to develop next-generation sensing technologies for exosome detection and analysis...
July 26, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28742080/emergent-remitted-and-persistent-psychosis-spectrum-symptoms-in-22q11-2-deletion-syndrome
#8
S X Tang, T M Moore, M E Calkins, J J Yi, D M McDonald-McGinn, E H Zackai, B S Emanuel, R C Gur, R E Gur
Individuals with 22q11.2 deletion syndrome (22q11DS) are at markedly elevated risk for schizophrenia-related disorders. Stability, emergence, remission and persistence of psychosis-spectrum symptoms were investigated longitudinally. Demographic, clinical and cognitive predictors of psychosis were assessed. Prospective follow-up over 2.8 years was undertaken in 75 individuals with 22q11DS aged 8-35 years. Mood, anxiety, attention-deficit hyperactivity disorders and psychosis-spectrum symptoms were assessed with the Kiddie-Schedule for Affective Disorders and Schizophrenia and Scale of Prodromal Symptoms (SOPS)...
July 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28741880/towards-extending-solar-cells-life-time-addition-of-a-fluorous-cation-to-triple-cation-based-perovskite-films
#9
Manuel Salado, M Asunción Fernández, Juan P Holgado, Samrana Kazim, M K Nazeeruddin, P J Dyson, Shahzada Ahmad
Organo metal halide perovskites have emerged as highly promising replacements for thin film solar cells. However, their poor stability under ambient conditions remains problematic, hindering commercial exploitation. Here, we describe our investigation on the incorporation of a fluorous-functionalized imidazolium cation in a highly stable cesium based mixed perovskite material (Cs0.05(MA0.15FA0.85)0.95Pb(I0.85Br0.15)3 and how it influnce enhances stability. The resulting materials, which vary according to the content of the fluorous-functionalized imidazolium cation, display a prolonged tolerance to atmospheric humidity (>100 days) along with power conversion efficiencies exceeding 16%...
July 25, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28741387/baseline-characteristics-and-treatment-patterns-of-patients-with-schizophrenia-initiated-on-once-every-three-month-paliperidone-palmitate-in-the-real-world-setting
#10
Kruti Joshi, Marie-Hélène Lafeuille, Brianne Brown, Willy Wynant, Bruno Emond, Patrick Lefebvre, Neeta Tandon
OBJECTIVES: Since May 2015, adult patients with schizophrenia adequately treated with once-monthly paliperidone palmitate (PP1M) may be transitioned to once-every-three-month paliperidone palmitate (PP3M). This study aims to describe baseline characteristics and treatment patterns of patients with schizophrenia initiated on PP3M in the real-world setting. METHODS: Pharmacy and medical claims from 05/2014-09/2016 for adult patients with schizophrenia initiated on PP3M (index date) in the Symphony Health Solutions database were analyzed...
July 25, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28740217/emergent-electronic-structure-of-cafe2as2
#11
Khadiza Ali, Kalobaran Maiti
CaFe2As2 exhibits collapsed tetragonal (cT) structure and varied exotic behaviour under pressure at low temperatures that led to debate on linking the structural changes to its exceptional electronic properties like superconductivity, magnetism, etc. Here, we investigate the electronic structure of CaFe2As2 forming in different structures employing density functional theory. The results indicate that the stability of the cT phase under pressure arises from the enhancement in hybridization induced effects and shift of the energy bands towards lower energies...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739792/transfersomal-phage-cocktail-an-effective-treatment-against-methicillin-resistant-s-aureus-mrsa-mediated-skin-and-soft-tissue-infections-sstis
#12
Sanjay Chhibber, Ashu Shukla, Sandeep Kaur
Emergence of drug resistance has rekindled the interest in phage therapy as an alternative treatment option. Its potency, safety and proven efficacy is worth noting. However, phage therapy still suffers from issues of poor stability, narrow spectrum and poor pharmacokinetic profile. It therefore becomes essential to look into the use of Drug Delivery Systems (DDS) for efficient delivery of lytic phages in vivo For the first time, the present study has evaluated the use of nano-structured lipid based carriers i...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28738391/updated-palate-surgery-for-obstructive-sleep-apnea
#13
Hsueh-Yu Li
Initially described in 1981, uvulopalatopharyngoplasty was the first surgical procedure specially designed at the palatal level for snoring and obstructive sleep apnea (OSA). To date, palatal surgery remains the most commonly used surgery for OSA. The advancement of this surgery over the past 30 years has been a process of evolution in concepts, examination, and technique to increase safety and effectiveness in the treatment of OSA. Concept changes have emerged in the disease etiology, purpose of surgery, treatment priorities, staging of operations, integration therapy, and surgical endpoints...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738069/inoculation-effects-on-root-colonizing-arbuscular-mycorrhizal-fungal-communities-spread-beyond-directly-inoculated-plants
#14
Martina Janoušková, Karol Krak, Miroslav Vosátka, David Püschel, Helena Štorchová
Inoculation with arbuscular mycorrhizal fungi (AMF) may improve plant performance at disturbed sites, but inoculation may also suppress root colonization by native AMF and decrease the diversity of the root-colonizing AMF community. This has been shown for the roots of directly inoculated plants, but little is known about the stability of inoculation effects, and to which degree the inoculant and the inoculation-induced changes in AMF community composition spread into newly emerging seedlings that were not in direct contact with the introduced propagules...
2017: PloS One
https://www.readbyqxmd.com/read/28737009/non-additive-stabilization-by-halogenated-amino-acids-reveals-protein-plasticity-on-a-sub-angstrom-scale
#15
Azade S Hosseini, Christopher J Pace, Adam A Esposito, Jianmin Gao
It has been a long-standing goal to understand the structure-stability relationship of proteins, as optimal stability is essential for protein function and highly desirable for protein therapeutics. Halogenation has emerged as a minimally invasive strategy to probe the physical characteristics of proteins in solution, as well as enhance the structural stabilities of proteins for therapeutic applications. Although advances in synthetic chemistry and genetic code expansion have allowed for the rapid synthesis of proteins with diverse chemical sequences, much remains to be learned regarding the impact of these mutations on their structural integrity...
July 24, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28735298/foxp1-related-intellectual-disability-syndrome-a-recognisable-entity
#16
Ilse Meerschaut, Daniel Rochefort, Nicole Revençu, Justine Pètre, Christina Corsello, Guy A Rouleau, Fadi F Hamdan, Jacques L Michaud, Jenny Morton, Jessica Radley, Nicola Ragge, Sixto García-Miñaúr, Pablo Lapunzina, Maria Palomares Bralo, Maria Ángeles Mori, Stéphanie Moortgat, Valérie Benoit, Sandrine Mary, Nele Bockaert, Ann Oostra, Olivier Vanakker, Milen Velinov, Thomy Jl de Ravel, Djalila Mekahli, Jonathan Sebat, Keith K Vaux, Nataliya DiDonato, Andrea K Hanson-Kahn, Louanne Hudgins, Bruno Dallapiccola, Antonio Novelli, Luigi Tarani, Joris Andrieux, Michael J Parker, Katherine Neas, Berten Ceulemans, An-Sofie Schoonjans, Darina Prchalova, Marketa Havlovicova, Miroslava Hancarova, Magdalena Budisteanu, Annelies Dheedene, Björn Menten, Patrick A Dion, Damien Lederer, Bert Callewaert
BACKGROUND: Mutations in forkhead box protein P1 (FOXP1) cause intellectual disability (ID) and specific language impairment (SLI), with or without autistic features (MIM: 613670). Despite multiple case reports no specific phenotype emerged so far. METHODS: We correlate clinical and molecular data of 25 novel and 23 previously reported patients with FOXP1 defects. We evaluated FOXP1 activity by an in vitro luciferase model and assessed protein stability in vitro by western blotting...
July 22, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28734026/falling-into-a-routine-from-habits-to-situated-practices
#17
Simon Cohn, Rebecca Lynch
In line with the concept of 'nudging' people to change their behaviour, there has been increased attention on habit as a focus for psychologically-based health interventions. It is hoped that behaviours initiated by interventions not only become so regular that they are normalised into people's everyday lives, but that through repetition they may eventually become fixed and habitual. In this paper we draw on people's accounts of participating in a trial designed to encourage greater physical activity, and attend to the ways they describe their engagement with interventions within wider narratives of their everyday lives...
July 21, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28733720/low-energy-chronic-traumatic-spondylolisthesis-of-the-axis
#18
Conor J Dunn, Samuel Mease, Kimona Issa, Kumar Sinha, Arash Emami
OBJECTIVE: The aim of this study is to present a unique case of a patient who presented to our Emergency Department with evidence of a chronic traumatic spondylolisthesis of the axis with severe displacement treated with anterior cervical discectomy and fusion (ACDF) of C2-C3 as well as and posterior cervical fusion (PCF) of C1-C3. METHODS: One patient with an untreated traumatic spondylolisthesis of the axis with Levine type II injury pattern and 1.2 cm of anterior subluxation underwent ACDF C2-C3 and PCF C1-C3...
July 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28732982/sonochemical-green-reduction-to-prepare-ag-nanoparticles-decorated-graphene-sheets-for-catalytic-performance-and-antibacterial-application
#19
Sayan Ganguly, Poushali Das, Madhuparna Bose, Tushar Kanti Das, Subhadip Mondal, Amit Kumar Das, Narayan C Das
The emerging popularity and wide acceptance of green chemistry and environmentally benign/ecofriendly approaches have comprehensively considered for catalyst synthesis methods. Natural resource derived carbogenic quantum dots has been used in assistance with ultrasonic shock wave to graphene oxide (GO) aqueous dispersion in order to prepare reduced graphene oxide decorated with silver nanoparticles following the 'top-down' method. The total reduction process is done without using any toxic external reducing agents and any surfactants or stabilizers, thus it can be accepted as green method...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732862/carbohydrate-functionalized-hybrid-latex-particles
#20
REVIEW
Niels M B Smeets, Spencer Imbrogno, Steven Bloembergen
In this review we highlight the progress in the synthesis of carbohydrate functionalized hybrid latex particles, focusing on different synthetic approaches which use carbohydrates as a surfactant/stabilizer, initiator, grafting site and/or as a macromonomer. These nanocomposites are receiving increasing attention in academia as well as in industry, due to increasingly stringent societal demands for biobased, biodegradable, and biocompatible materials. Furthermore, we will report on the use of nanostructured carbohydrate materials, such as cellulose nanocrystals, starch nanocrystals, and starch nanoparticles...
October 1, 2017: Carbohydrate Polymers
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