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https://www.readbyqxmd.com/read/28213377/interventional-treatment-of-pulmonary-embolism
#1
David M Dudzinski, Jay Giri, Kenneth Rosenfield
Pulmonary embolism (PE) is a serious and prevalent cause of vascular disease. Nevertheless, optimal treatment for many phenotypes of PE remains uncertain. Treating PE requires appropriate risk stratification as a first step. For the highest-risk PE, presenting as shock or arrest, emergent systemic thrombolysis or embolectomy is reasonable, while for low-risk PE, anticoagulation alone is often chosen. Normotensive patients with PE but with indicia of right heart dysfunction (by biomarkers or imaging) constitute an intermediate-risk group for whom there is controversy on therapeutic strategy...
February 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28212444/sumo-modification-of-a-heterochromatin-histone-demethylase-jmjd2a-enables-viral-gene-transactivation-and-viral-replication
#2
Wan-Shan Yang, Mel Campbell, Pei-Ching Chang
Small ubiquitin-like modifier (SUMO) modification of chromatin has profound effects on transcription regulation. By using Kaposi's sarcoma associated herpesvirus (KSHV) as a model, we recently demonstrated that epigenetic modification of viral chromatin by SUMO-2/3 is involved in regulating gene expression and viral reactivation. However, how this modification orchestrates transcription reprogramming through targeting histone modifying enzymes remains largely unknown. Here we show that JMJD2A, the first identified Jumonji C domain-containing histone demethylase, is the histone demethylase responsible for SUMO-2/3 enrichment on the KSHV genome during viral reactivation...
February 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28211670/facile-synthesis-of-unique-hexagonal-nanoplates-of-zn-co-hydroxy-sulfate-for-efficient-electrocatalytic-oxygen-evolution-reaction
#3
Soumen Dutta, Chaiti Ray, Yuichi Negishi, Tarasankar Pal
Cost-effective, highly active water oxidation catalysts are becoming increasingly demanding in the field of energy conversion and storage. Herein, simple modified hydrothermally (MHT) synthesized zinc and cobalt based hydroxyl double salt i.e., Zn4-xCoxSO4(OH)6• 0.5 H2O (ZCS) has been exfoliated for the first time as an efficient electrocatalyst for oxygen evolution reaction (OER) in alkaline medium. Morphology investigation suggests the evolution of unique hexagonal nanoplates of ZCS material. As OER catalyst, it requires only 370 and 450 mV overpotential to achieve 10 and 100 mA cm-2 current density respectively...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28211363/nanowire-networks-and-hollow-nanospheres-of-ag-au-bimetallic-alloys-at-room-temperature
#4
R Britto Hurtado, M Cortez-Valadez, H Arizpe-Chávez, N S Flores-Lopez, Ramón A B Álvarez, M Flores-Acosta
Due to their physicochemical properties, metallic nanoalloys have potential applications in biomedicine, electrocatalysis and electrochemical sensors, among many other fields. New alternative procedures have emerged in order to reduce production costs and the use of toxic substances. In this study we present a novel low-toxicity synthesis method for the fabrication of nanowire networks (NWNs) and Ag-Au hollow nanospheres. The synthesis process is performed at room temperature without any sophisticated equipment, such as special cameras or furnaces, etc...
March 17, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28211249/improving-the-interpretability-of-climate-landscape-metrics-an-ecological-risk-analysis-of-japan-s-marine-protected-areas
#5
Jorge García Molinos, Shintaro Takao, Naoki H Kumagai, Elvira S Poloczanska, Michael T Burrows, Masahiko Fujii, Hiroya Yamano
Conservation efforts strive to protect significant swaths of terrestrial, freshwater and marine ecosystems from a range of threats. As climate change becomes an increasing concern, these efforts must take into account how resilient protected spaces will be in the face of future drivers of change such as warming temperatures. Climate landscape metrics, which signal the spatial magnitude and direction of climate change, support a convenient initial assessment of potential threats to and opportunities within ecosystems to inform conservation and policy efforts where biological data are not available...
February 17, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28210414/eye-inside-out-endonasal-endoscopic-reposition-of-eye-from-nose-with-complete-vision-regainment
#6
Girish S Mishra, Sushen Harish Bhatt
Faciomaxillary and ocular trauma is a common entity in most emergency and trauma units. We came across a 68-year-old female patient with a history of bull horn injury over the right eye. Examination revealed an empty orbital socket with unreliable perception of light present. Imaging showed that the eye had displaced posteroinferomedially to be lying in the ethmoid air cells in the nasal cavity. Under nasal endoscopic guidance, the eye was reposited back into the orbital socket and conjunctival sutures were taken to stabilize the position...
March 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28209339/vitamin-e-stabilized-highly-crosslinked-polyethylenes-the-role-and-effectiveness-in-total-hip-arthroplasty
#7
Kengo Yamamoto, Toshiyuki Tateiwa, Yasuhito Takahashi
Morphology and design of ultra-high molecular weight polyethylene (UHMWPE or simply PE) acetabular components used in total hip arthroplasty (THA) have been evolving for more than half a century. Since the late-1990s, there were two major technological innovations in PE emerged from necessity to overcome the wear-induced periprosthetic osteolysis, i.e., the development of highly crosslinked PEs (HXLPEs). There are many literature reporting that radiation crosslinked and remelted/annealed (first-generation) HXLPEs markedly reduced the incidence of osteolysis and aseptic loosening...
February 10, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28208961/fracture-supracondylar-humerus-a-review
#8
REVIEW
Vineet Kumar, Ajai Singh
Fracture supracondylar humerus is one of the most common fractures encountered in pediatric age group at all levels (both rural and urban). Thus it needs a special review in its management protocol as per the changing trend. Modified Gartland classification is the most accepted classification and has its importance in decision making regarding management and prognosis. Neurovascular complications are mostly associated with Type III A, III B and Type IV variety and they most of the time need surgical intervention for stabilization, exploration of brachial artery, sometimes median nerve exploration and reduction of fracture...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208818/hydroxycinnamic-acids-and-their-derivatives-cosmeceutical-significance-challenges-and-future-perspectives-a-review
#9
Oludemi Taofiq, Ana M González-Paramás, Maria Filomena Barreiro, Isabel C F R Ferreira
Bioactive compounds from natural sources, due to their widely-recognized benefits, have been exploited as cosmeceutical ingredients. Among them, phenolic acids emerge with a very interesting potential. In this context, this review analyzes hydroxycinnamic acids and their derivatives as multifunctional ingredients for topical application, as well as the limitations associated with their use in cosmetic formulations. Hydroxycinnamic acids and their derivatives display antioxidant, anti-collagenase, anti-inflammatory, antimicrobial and anti-tyrosinase activities, as well as ultraviolet (UV) protective effects, suggesting that they can be exploited as anti-aging and anti-inflammatory agents, preservatives and hyperpigmentation-correcting ingredients...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28208748/neighborhood-factors-and-fall-related-injuries-among-older-adults-seen-by-emergency-medical-service-providers
#10
Sungmin Lee, Chanam Lee, Susan Rodiek
Falls are serious health problems among older adults, and are the leading cause of fatal and nonfatal injuries treated by emergency medical services (EMS). Although considerable research has examined the risk factors of falls at the individual level, relatively few studies have addressed the risk factors at the neighborhood level. This study examines the characteristics of neighborhood environments associated with fall injuries reported to EMS providers. A total of 13,163 EMS records from 2011 to 2014 involving adults aged 65 and older in the city of San Antonio (TX, USA) were analyzed at the census tract level (n = 264)...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28208574/complexation-of-phytochemicals-with-cyclodextrin-derivatives-an-insight
#11
REVIEW
Vasanti Suvarna, Parul Gujar, Manikanta Murahari
Natural compounds have been attracting huge attention because of their broad therapeutic properties with specificity in their action in human health care as functional foods, pharmaceuticals and nutraceuticals. However poor bioavailability and reduced bioactivity attributed to poor solubility and instability is the major drawback hindering the incorporation of these therapeutically potential molecules in novel drug delivery systems. Based on the findings of reported research investigations; complexation of poorly water soluble phytochemicals with cyclodextrins has emerged to be a promising approach to improve their aqueous solubility, stability, rate of dissolution and bioavailability...
February 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28208471/analysis-of-thermodiffusive-cellular-instabilities-in-continuum-combustion-fronts
#12
Hossein Azizi, Sebastian Gurevich, Nikolas Provatas
We explore numerically the morphological patterns of thermodiffusive instabilities in combustion fronts with a continuum fuel source, within a range of Lewis numbers and ignition temperatures, focusing on the cellular regime. For this purpose, we generalize the recent model of Brailovsky et al. to include distinct process kinetics and reactant heterogeneity. The generalized model is derived analytically and validated with other established models in the limit of infinite Lewis number for zero-order and first-order kinetics...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207240/interfaces-in-heterogeneous-catalysts-advancing-mechanistic-understanding-through-atomic-scale-measurements
#13
Wenpei Gao, Zachary D Hood, Miaofang Chi
Developing novel catalysts with high efficiency and selectivity is critical for enabling future clean energy conversion technologies. Interfaces in catalyst systems have long been considered the most critical factor in controlling catalytic reaction mechanisms. Interfaces include not only the catalyst surface but also interfaces within catalyst particles and those formed by constructing heterogeneous catalysts. The atomic and electronic structures of catalytic surfaces govern the kinetics of binding and release of reactant molecules from surface atoms...
February 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28206750/synthetic-riboswitches-from-plug-and-pray-towards-plug-and-play
#14
Maja Etzel, Mario Mörl
In synthetic biology, metabolic engineering as well as gene therapy there is a strong demand for orthogonal or externally controlled regulation of gene expression. Here, RNA-based regulatory devices represent a promising emerging alternative to proteins, allowing a fast and direct control of gene expression, as no synthesis of regulatory proteins is required. Besides programmable ribozyme elements controlling mRNA stability, regulatory RNA structures in untranslated regions are highly interesting for engineering approaches...
February 16, 2017: Biochemistry
https://www.readbyqxmd.com/read/28202710/practical-data-handling-pipeline-improves-performance-of-qpcr-based-circulating-mirna-measurements
#15
Maurice W J de Ronde, Jan M Ruijter, David Lanfear, Antoni Bayes-Genis, Maayke Kok, Esther Creemers, Yigal M Pinto, Sara-Joan Pinto-Sietsma
BACKGROUND: Since numerous miRNAs have been shown to be present in the circulation, these so-called circulating miRNAs have emerged as potential biomarkers for disease. However, results of qPCR studies on circulating miRNA biomarkers vary greatly and many experiments cannot be reproduced. Missing data in qPCR experiments often occur due to off-target amplification, non-analyzable qPCR curves and discordance between replicates. The low concentration of most miRNAs leads to most, but not all missing data...
February 15, 2017: RNA
https://www.readbyqxmd.com/read/28202413/engineered-antibody-ch2-domains-binding-to-nucleolin-isolation-characterization-and-improvement-of-aggregation
#16
De-Zhi Li, Rui Gong, Jun Zheng, Xi-Hai Chen, Dimiter S Dimitrov, Qi Zhao
Smaller recombinant antibody fragments are now emerging as alternatives of conventional antibodies. Especially, immunoglobulin (Ig) constant CH2 domain and engineered CH2 with improved stability are promising as scaffolds for selection of specific binders to various antigens. We constructed a yeast display library based on an engineered human IgG1 CH2 scaffold with diversified loop regions. A group of CH2 binders were isolated from this yeast display library by panning against nucleolin, which is a tumor-associated antigen involved in cell proliferation, tumor cell growth and angiogenesis...
February 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28199752/effect-of-transversus-abdominis-plane-block-in-combination-with-general-anesthesia-on-perioperative-opioid-consumption-hemodynamics-and-recovery-in-living-liver-donors-the-prospective-double-blinded-randomized-study
#17
Mehmet Ali Erdogan, Ulku Ozgul, Muharrem Uçar, Rıdvan Yalin, Yusuf Ziya Colak, Cemil Çolak, Huseyin Ilksen Toprak
BACKGROUND: Transversus abdominis plane (TAP) block provides effective postoperative analgesia after abdominal surgeries. It can be also a useful strategy to reduce perioperative opioid consumption, support intraoperative hemodynamic stability and promote early recovery from anesthesia. The aim of this prospective randomized double-blind study was to assess the effect of subcostal TAP blocks on perioperative opioid consumption, hemodynamic and recovery time in living liver donors. METODS: The prospective, double-blinded, randomized controlled study was conducted with 49 living liver donors, aged 18-65 years, who were scheduled to undergo right hepatectomy...
February 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28199096/why-porous-materials-have-selective-adsorptions-a-rational-aspect-from-electrodynamics
#18
Qiang Chen, Yuguang Ma, Wei-Chao Song, Ze Chang, Jian-Rong Li, Jun Zhang, Hong-Wei Sun, Perla B Balbuena, Xian-He Bu
Gas storage/separation is a typical application of porous materials such as metal organic frameworks (MOFs). The adsorption/separation behavior results from the host-guest and/or guest-guest interaction and equilibration (host, porous material; guest, adsorbates). Although the driving forces for gas adsorption have been investigated, a detailed picture of interactions between gas molecules and MOFs has not clearly emerged. Herein, a new cobalt microporous MOF [Co(tipb)(adc)](DMF)3(H2O)1.5, which possesses a rare self-interpenetrated gra topology, has been prepared with both tipb and H2adc ligands (tipb = 1,3,5-tris(p-imidazolylphenyl)benzene, adc = 9,10-anthracenedicarboxylate)...
February 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28199037/stability-and-change-in-patterns-of-eating-disorder-symptoms-from-adolescence-to-young-adulthood
#19
Carolyn M Pearson, Jonathan Miller, Diann M Ackard, Katie A Loth, Melanie M Wall, Ann F Haynos, Dianne Neumark-Sztainer
Using a community adolescent sample, we aimed to (a) empirically derive eating disorder (ED) symptom groups, (b) examine the longitudinal stability of those groups over 10 years, and (c) identify risk factors associated with ED group stability and transition through young adulthood. Young people (N = 2,287) from the Project EAT cohort participated at baseline (1998-1999) and at 10-year follow-up (2008-2009). Participants completed anthropometric measures at baseline and self-report surveys on disordered eating symptoms and risk factors at both time points...
February 15, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28198436/theory-of-skyrmions-in-bilayer-systems
#20
Wataru Koshibae, Naoto Nagaosa
Skyrmion is an emergent particle consisting of many spins in magnets, and has many nontrivial features such as (i) nano-scale size, (ii) topological stability, (iii) gyrodynamics, and (iv) highly efficient spin transfer torque, which make skyrmions the promising candidate for the magnetic devices. Earlier works were focusing on the bulk or thin film of Dzyaloshinskii-Moriya (DM) magnets, while recent advances are focusing on the skyrmions induced by the interfaces. Therefore, the superstructures naturally leads to the interacting skyrmions on different interfaces, which has unique dynamics compared with those on the same interface...
February 15, 2017: Scientific Reports
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