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https://www.readbyqxmd.com/read/28938602/activation-of-cancerous-inhibitor-of-pp2a-cip2a-contributes-to-lapatinib-resistance-through-induction-of-cip2a-akt-feedback-loop-in-erbb2-positive-breast-cancer-cells
#1
Ming Zhao, Erin W Howard, Amanda B Parris, Zhiying Guo, Qingxia Zhao, Zhikun Ma, Ying Xing, Bolin Liu, Susan M Edgerton, Ann D Thor, Xiaohe Yang
Lapatinib, a small molecule ErbB2/EGFR inhibitor, is FDA-approved for the treatment of metastatic ErbB2-overexpressing breast cancer; however, lapatinib resistance is an emerging clinical challenge. Understanding the molecular mechanisms of lapatinib-mediated anti-cancer activities and identifying relevant resistance factors are of pivotal significance. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified oncoprotein that is overexpressed in breast cancer. Our study investigated the role of CIP2A in the anti-cancer efficacy of lapatinib in ErbB2-overexpressing breast cancer cells...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28936977/the-current-research-status-of-enhancer-rnas
#2
Xiao Cheng, Qiong Yang, Zhen-Dong Tan, Ya Tan, Hongzhou Pu, Xue Zhao, Shun-Hua Zhang, Li Zhu
Enhancers are key cis-acting gene regulatory elements in eukaryotes, which can effectively promote the expression of target genes. Emerging evidence showed that enhancers in activation state could be transcribed to enhancer RNAs (eRNAs), the processes of which are regulated by various signaling systems and actions of signal-dependent transcription factors. Compared with the other transcripts (e.g. lncRNA, mRNA), eRNAs have shorter sequences, lower stability, and higher tissue specificity. eRNAs play roles in the initiation or stabilization of enhancer-promoter looping, and promote the expression of target genes...
September 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28934705/vitamin-c-the-next-step-in-sepsis-management
#3
REVIEW
J Teng, A Pourmand, M Mazer-Amirshahi
Sepsis is a life-threatening medical condition, affecting approximately 26 million people worldwide every year. The disease is a continuum, marked by dysregulated inflammation and hemodynamic instability leading to shock, multi-system organ dysfunction, and death. Over the past decades, there has been a focus on the early identification and treatment of sepsis primarily with bundled and goal directed therapy. Despite these advances, morbidity and mortality has remained high, prompting investigation into novel therapies...
September 18, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28933921/are-you-ready-to-have-fun-the-spanish-state-form-of-the-state-trait-cheerfulness-inventory
#4
Raúl López-Benítez, Alberto Acosta, Juan Lupiáñez, Hugo Carretero-Dios
Although cheerfulness, seriousness, and bad mood as traits have been widely studied as the basis of sense of humor, data are scarce regarding the same dimensions as states. In this study, we adapted the state form of the State-Trait-Cheerfulness Inventory (STCI-S) into Spanish. At the same time, we empirically tested new predictions. We assessed 5 independent samples accounting for 1,029 participants (647 women) with ages ranging from 18 to 78 years. We confirmed the 3-dimensional structure as well as a strong measurement invariance between men and women...
September 21, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28933843/cspb0-9sn0-1ibr2-based-all-inorganic-perovskite-solar-cells-with-exceptional-efficiency-and-stability
#5
Jia Liang, Peiyang Zhao, Caixing Wang, Yanrong Wang, Yi Hu, Guoyin Zhu, Lianbo Ma, Jie Liu, Zhong Jin
The emergence of perovskite solar cells (PSCs) has generated enormous interests in the photovoltaic research community. Recently, cesium metal halides (CsMX3, M = Pb or Sn; X = I, Br, Cl or mixed halides) as a class of inorganic perovskites showed great promise for PSCs and other optoelectronic devices. However, CsMX3-based PSCs usually exhibit lower power conversion efficiencies (PCEs) than organic-inorganic hybrid PSCs, due to the unfavorable bandgaps. Herein, a novel mixed-Pb/Sn mixed-halide inorganic perovskite, CsPb0...
September 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28932818/impact-of-cell-culture-parameters-on-production-and-vascularization-bioactivity-of-mesenchymal-stem-cell-derived-extracellular-vesicles
#6
Divya B Patel, Kelsey M Gray, Yasasvhinie Santharam, Tek N Lamichhane, Kimberly M Stroka, Steven M Jay
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have emerged as potential therapeutic agents for numerous applications. EVs offer potential advantages over cell-based therapies with regard to safety, stability and clearance profiles, however production and potency limitations must be addressed to enable eventual translation of EV-based approaches. Thus, we sought to examine the role of specific cell culture parameters on MSC EV production and bioactivity toward informing rational design parameters for scalable EV biomanufacturing...
June 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/28932360/very-late-bioresorbable-scaffold-thrombosis-and-reoccurrence-of-dissection-two-years-later-chronic-total-occlusion-recanalization-of-the-left-anterior-descending-artery
#7
Luigi Di Serafino, Plinio Cirillo, Tullio Niglio, Francesco Borgia, Bruno Trimarco, Giovanni Esposito, Eugenio Stabile
We describe the case of a patient presenting with ST-segment elevation myocardial infarction due to very late scaffold thrombosis. The patient was already admitted for an elective percutaneous recanalization of a chronically occluded left anterior descending artery (LAD). The procedure was performed according the sub-intimal tracking and re-entry (STAR) technique with 4 bioresorbable vascular scaffolds implantation. However, even though the coronary flow was preserved at the end of the procedure, the dissected segment was only partially sealed at the distal segment of the LAD...
August 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28931464/the-interactive-effects-of-diclofop-methyl-and-silver-nanoparticles-on-arabidopsis-thaliana-growth-photosynthesis-and-antioxidant-system
#8
Xingxing Li, Mingjing Ke, Meng Zhang, W J G M Peijnenburg, Xiaoji Fan, Jiahui Xu, Zhenyan Zhang, Tao Lu, Zhengwei Fu, Haifeng Qian
Diclofop-methyl (DM), a common post-emergence herbicide, is frequently used in agricultural production. Silver nanoparticles (AgNPs) are one of the most widely used nanoparticles, and as such, have been detected and monitored in several environmental systems. Here we investigated the interactive effects of DM and AgNPs on the physiological morphology, photosynthesis and antioxidant system of Arabidopsis thaliana. Our results demonstrated that a 1.0 mg/L DM treatment had no significant effect on the fresh weight of plant shoots and the content of total chlorophyll and anthocyanin...
September 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28930951/routine-computed-tomography-after-recent-operative-exploration-for-penetrating-trauma-what-injuries-do-we-miss
#9
April E Mendoza, Christopher A Wybourn, Anthony G Charles, Andre R Campbell, Bruce A Cairns, Margaret M Knudson
BACKGROUND: Patients with penetrating trauma who cannot be stabilized undergo operative intervention without preoperative imaging. In such cases, postoperative imaging may reveal additional injuries not identified during the initial operative exploration. The purpose of this study is to explore the utility of postoperative CT imaging in the setting of penetrating trauma. METHODS: This was a retrospective analysis of patients with penetrating trauma treated at an urban Level 1 trauma center between 2010 and 2015...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930083/differential-patterns-of-batrachochytrium-dendrobatidis-infection-in-relict-amphibian-populations-following-severe-disease-associated-declines
#10
Steven M Whitfield, Gilbert Alvarado, Juan Abarca, Hector Zumbado, Ibrahim Zuñiga, Mark Wainwright, Jacob Kerby
Global amphibian biodiversity has declined dramatically in the past 4 decades, and many amphibian species have declined to near extinction as a result of emergence of the amphibian chytrid fungus, Batrachochytrium dendrobatidis (Bd). However, persistent or recovering populations of several amphibian species have recently been rediscovered, and such populations may illustrate how amphibian species that are highly susceptible to chytridiomycosis may survive in the presence of Bd. We conducted field surveys for Bd infection in 7 species of Costa Rican amphibians (all species that have declined to near extinction but for which isolated populations persist) to characterize infection profiles in highly Bd-susceptible amphibians post-decline...
September 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28928575/referrral-systems-development-and-survey-of-perioperative-and-critical-care-referral-to-anesthetists
#11
P L Narendra, Harihar V Hegde, Maroof Ahmad Khan, Dayanand G Talikoti, Samson Nallamilli
INTRODUCTION: Anesthetists come in contact with more than two-third of hospital patients. Timely referral to anesthetists is vital in perioperative and remote site settings. Delayed referrals, improper referrals, and referrals at inappropriate levels can result in inadequate preparation, perioperative complications, and poor outcome. METHODS: The self administered paper survey to delegates attending anesthesia conferences. Questions were asked on how high-risk, emergency surgical cases remote site and critical care patients were referred to anesthetists and presence of rapid response teams...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28925905/nanomedicine-in-the-diagnosis-and-treatment-of-atherosclerosis-a-systematic-review
#12
Kannan Vaidyanathan, Sandhya Gopalakrishnan
BACKGROUND: Atherosclerosis is a chronic inflammatory condition causing very high morbidity and mortality. It is characterized by accumulation of plaques within arteries. Nanomedicine is an emerging field of medicine utilizing nanotechnology for advanced imaging and therapy. Nanomedicine has led to significant developments in the field of cardiovascular diseases, including atherosclerosis. Many nanoformulations have been developed with anti-atherosclerotic effects. Nanomedicine tools have been used in the imaging of atherosclerosis...
September 18, 2017: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28925263/partially-reversible-photo-induced-chemical-changes-in-a-mixed-ion-perovskite-material-for-solar-cells
#13
Ute B Cappel, Sebastian Svanström, Valeria Lanzilotto, Fredrik Oskar Lars Johansson, Kerttu Aitola, Bertrand Philippe, Erika Giangrisostomi, Ruslan Ovsyannikov, Torsten Leitner, Alexander Foehlisch, Svante Svensson, Nils Mårtensson, Gerrit Boschloo, Andreas Lindblad, Håkan Rensmo
Metal halide perovskites have emerged as materials of high interest for solar energy to electricity conversion and in particular the use of mixed ion structures has led to high power conversion efficiencies and improved stability. For this reason, it is important develop means to obtain atomic level understanding of the photo-induced behaviour of these materials including processes such as photo-induced phase separation and ion migration. In this paper, we implement a new methodology combining visible laser illumination of a mixed-ion perovskite ((FAPbI3)0...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28924505/greater-reproductive-investment-but-shorter-lifespan-in-agrosystem-than-in-natural-habitat-toads
#14
Francisco Javier Zamora-Camacho, Mar Comas
Global amphibian decline is due to several factors: habitat loss, anthropization, pollution, emerging diseases, and global warming. Amphibians, with complex life cycles, are particularly susceptible to habitat alterations, and their survival may be impaired in anthropized habitats. Increased mortality is a well-known consequence of anthropization. Life-history theory predicts higher reproductive investment when mortality is increased. In this work, we compared age, body size, and different indicators of reproductive investment, as well as prey availability, in natterjack toads (Epidalea calamita) from agrosystems and adjacent natural pine groves in Southwestern Spain...
2017: PeerJ
https://www.readbyqxmd.com/read/28920977/axial-substitution-of-a-precursor-resulted-in-two-high-energy-copper-ii-complexes-with-superior-detonation-performances
#15
Xin Li, Qi Yang, Qing Wei, Gang Xie, Sanping Chen, Shengli Gao
The design and synthesis of explosives with high performance, good thermal stability, and low sensitivity is an important subject for the development of energetic materials. Energetic complexes have recently emerged as a promising energetic material form. As one of the representatives, [Cu(Htztr)2(H2O)2]n (H2tztr = 3-(1H-tetrazol-5-yl)-1H-triazole) was previously reported with good energetic performance, outstanding thermostability (Tdec = 345 °C) and low sensitivity to impact and friction stimuli. However, due to the existence of water molecules, its effective energy density is remarkably decreased, resulting in a diminished detonation performance...
September 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28920511/a-feasibility-study-of-working-memory-training-for-individuals-with-paediatric-onset-multiple-sclerosis
#16
Christine Till, Bravina Kuni, Elisea De Somma, E Ann Yeh, Brenda Banwell
OBJECTIVE: To investigate the feasibility and experiences of paediatric-onset multiple sclerosis (MS) patients completing a working memory training programme. METHODS: Nine paediatric-onset MS patients (mean age 19.3 ± 4.1 years) identified as having attention and/or working memory difficulties underwent a five-week (five days/week) internet-based working memory training programme (Cogmed™); weekly coaching was provided. Measures of adherence and tolerance were used to establish the feasibility of implementing computerised cognitive training...
September 18, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28920434/ultralow-temperature-solution-processed-aluminum-oxide-dielectrics-via-local-structure-control-of-nanoclusters
#17
Jeong-Wan Jo, Yong-Hoon Kim, Joohyung Park, Jae Sang Heo, Seongpil Hwang, Won-June Lee, Myung-Han Yoon, Myung-Gil Kim, Sung Kyu Park
Oxide dielectric materials play a key role in a wide range of high-performance solid-state electronics from semiconductor devices to emerging wearable and soft bio-electronic devices. Although lots of previous advances are noteworthy, their typical processing temperature still far exceeds the thermal limitations of soft materials, impeding their wide utilization in these emerging fields. Here, we report an innovative route to form highly reliable aluminum-oxide dielectric films using an ultralow temperature (< 60 ˚C) solution process with a class of oxide nanocluster precursors...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28918418/new-aspects-in-the-pathomechanism-of-diseases-of-civilization-particularly-psychosomatic-disorders-part-1-theoretical-background-of-a-hypothesis
#18
Andras Sikter, Zoltan Rihmer, Roberto de Guevara
The stress defence-cascade is mostly not biphasic as Cannon thought, the sympathicotonic stress response is preceded by a vagotonic phase called freeze response. Alteration of the carbon dioxide level plays an important role during defence-cascade as its changes interfere with stress hormones, e.g. with catecholamines, thus affecting the degree of arousal. In case of humans, learned behaviour dominates instead of instinctive, so the fight-or-flight often lags; the consequence can be persistent hypocapnia or hypercapnia...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28917872/crystalline-nanocellulose-lauric-arginate-complexes
#19
Kai Chi, Jeffrey M Catchmark
As a novel sustainable nanomaterial, crystalline nanocellulose (CNC) possesses many unique characteristics for emerging applications in coatings, emulsions, paints, pharmaceutical formulations, and other aqueous composite systems where interactions with oppositely charged surfactants are commonly employed. Herein, the binding interactions between sulfated CNC and a novel biologically-derived cationic surfactant lauric arginate (LAE) were comprehensively examined. Ionic strength and solution pH are two crucial factors in determining the adsorption of LAE to the CNC surface...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917670/morphological-characterization-and-biocontrol-effects-of-vibrio-vulnificus-phages-against-vibriosis-in-the-shrimp-aquaculture-environment
#20
P Srinivasan, P Ramasamy
The re-emerging field of phage therapy is the potential biocontrol agents for the transfer of virulence factor and to kill their bacterial hosts. In this study, the lytic Vibrio vulnificus phages were studied to provide a better understanding of phage-host interactions and development of phage therapy. Four new V. vulnificus phages were detected from shrimp aquaculture system, named VV1, VV2, VV3 and VV4. All lytic V. vulnificus phages are the Tecviruses of the family Tectiviridae with typical double layered elongated icosahedral head and tailless morphology...
September 13, 2017: Microbial Pathogenesis
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