keyword
https://read.qxmd.com/read/38528176/a-combination-nutritional-supplement-reduces-dna-methylation-age-only-in-older-adults-with-a-raised-epigenetic-age
#1
JOURNAL ARTICLE
Kirsty C McGee, Jack Sullivan, Jon Hazeldine, Lisa J Schmunk, Daniel E Martin-Herranz, Thomas Jackson, Janet M Lord
An increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks can quantify the degree of biological aging and this can be reversed by lifestyle and pharmacological intervention. We aimed to investigate whether a multi-component nutritional supplement could reduce systemic inflammation and epigenetic age in healthy older adults.We recruited 80 healthy older participants (mean age ± SD: 71.85 ± 6.23; males = 31, females = 49)...
March 26, 2024: GeroScience
https://read.qxmd.com/read/38518540/joint-effects-of-one-year-of-marine-omega-3-fatty-acid-supplementation-and-participant-dietary-fish-intake-upon-circulating-lipid-mediators-of-inflammation-resolution-in-a-randomized-controlled-trial
#2
JOURNAL ARTICLE
Emily G Oakes, Iliyan Vlasakov, Gregory Kotler, Vadim Bubes, Samia Mora, Raju Tatituri, Nancy R Cook, JoAnn E Manson, Karen H Costenbader
OBJECTIVES: We assessed the joint effects of omega (n)-3 fatty acid supplementation and dietary fish intake on systemic lipid mediators of inflammation among adults. METHODS: Within VITAL, a double-blind randomized controlled trial, adults were randomized to ω-3 fatty acids (460 mg EPA + 380 mg DHA/d) or placebo. We selected participants who reported low (<1 serving/mo) baseline dietary fish intake and matched them by age, sex, race, and trial arm to participants with self-reported highest fish intake (≥3...
February 28, 2024: Nutrition
https://read.qxmd.com/read/38518085/association-of-plasma-n-3-polyunsaturated-fatty-acid-levels-and-the-prevalence-of-frailty-in-older-adults-a-cross-sectional-analysis-of-uk-biobank
#3
JOURNAL ARTICLE
Junghyun Kim, Jason Westra, Nathan Tintle, William S Harris, Yongsoon Park
BACKGROUND: Circulating levels of n-3 polyunsaturated fatty acids (PUFAs) have been associated with frailty among Koreans (a population with a high intake of fish), but whether this association exists in Western populations with low fish intake is unknown. The present study examined the hypothesis that the prevalence of frailty was inversely associated with plasma levels of n-3 PUFAs, with the intake of oily fish, and with fish oil supplementation in older adults in the UK. METHODS: UK Biobank including 79,330 adults aged ≥ 65 years with dietary data, and 18,802 participants with plasma fatty acid data were used...
March 22, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38505970/amelioration-of-obesity-induction-by-a-high-fat-diet-and-related-inflammation-by-phasa-fish-setipinna-phasa-oil-in-balb-c-mice
#4
JOURNAL ARTICLE
Titli Panchali, Ananya Dutta, Pipika Das, Amina Khatun, Riya Kar, Subhadeep Mondal, Keshab Chandra Mondal, Sudipta Chakrabarti, Kuntal Ghosh, Shrabani Pradhan
We have extracted and characterized Phasa fish (Setipinna phasa) oil for the first time to evaluate the anti-obesity and related anti-inflammatory effects on obese mice. Inbred male albino BALB/c mice were segregated into three categories: control (C), Obese control group (OC), and Phasa fish oil treated group (TX). To establish the potentiality of Setipinna phasa oil for its anti-obesity and anti-inflammatory properties, it was extracted and characterized using GC-MS method. To evaluate the anti-obesity effect, different parameters were considered, such as body weight, lipid composition, obesity, and obesity associated inflammation...
March 2024: Journal of Applied Biomedicine
https://read.qxmd.com/read/38501107/comparison-of-the-effects-of-monounsaturated-fatty-acids-and-polyunsaturated-fatty-acids-on-the-lipotoxicity-of-islets
#5
JOURNAL ARTICLE
Wen Liu, Min Zhu, Jingyi Liu, Shan Su, Xin Zeng, Fudong Fu, Yanrong Lu, Zhiyong Rao, Younan Chen
BACKGROUND: Monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) have been reported to combat saturated fatty acid (SFA)-induced cellular damage, however, their clinical effects on patients with metabolic diseases such as diabetes and hyperlipidemia are still controversial. Since comparative studies of the effects of these two types of unsaturated fatty acids (UFAs) are still limited. In this study, we aimed to compare the protective effects of various UFAs on pancreatic islets under the stress of SFA-induced metabolic disorder and lipotoxicity...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38484976/dietary-n-3-polyunsaturated-fatty-acids-alter-the-number-fatty-acid-profile-and-coagulatory-activity-of-circulating-and-platelet-derived-extracellular-vesicles-a-randomized-controlled-crossover-trial
#6
JOURNAL ARTICLE
Esra Bozbas, Ruihan Zhou, Shin Soyama, Keith Allen-Redpath, Joanne L Mitchell, Helena L Fisk, Philip C Calder, Chris Jones, Jonathan M Gibbins, Roman Fischer, Svenja Hester, Parveen Yaqoob
BACKGROUND: Extracellular vesicles (EVs) are proposed to play a role in the development of cardiovascular diseases (CVDs) and are considered emerging markers of CVDs. N-3 polyunsaturated fatty acids (PUFAs) are abundant in oily fish and fish oil and are reported to reduce CVD risk, but there has been little research to date examining the effects of n-3 PUFAs on the generation and function of EVs. OBJECTIVE: The objective of the study was to investigate the effects of fish oil supplementation on the number, generation and function of EVs in subjects with moderate risk of CVDs...
March 12, 2024: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38474762/effect-of-dietary-supplementation-with-omega-3-fatty-acid-on-the-generation-of-regulatory-t-lymphocytes-and-on-antioxidant-parameters-and-markers-of-oxidative-stress-in-the-liver-tissue-of-il-10-knockout-mice
#7
JOURNAL ARTICLE
Daniela Dalpubel Campanari, Ualter Guilherme Cipriano, Thais Fernanda de Campos Fraga-Silva, Leandra Náira Zambelli Ramalho, Paula Payão Ovidio, Alceu Afonso Jordão Júnior, Vânia Luiza Deperon Bonato, Eduardo Ferriolli
INTRODUCTION: chronic low-grade inflammation, or inflammaging, emerges as a crucial element in the aging process and is associated with cardiovascular and neurological diseases, sarcopenia, and malnutrition. Evidence suggests that omega-3 fatty acids present a potential therapeutic agent in the prevention and treatment of inflammatory diseases, mitigating oxidative stress, and improving muscle mass, attributes that are particularly relevant in the context of aging. The objective of the present study was to evaluate the effectiveness of supplementation with omega-3 fish oil in improving the immune response and oxidative stress in knockout mice for interleukin IL-10 (IL-10-/- )...
February 24, 2024: Nutrients
https://read.qxmd.com/read/38474759/thermodynamic-analysis-to-evaluate-the-effect-of-diet-on-brain-glucose-metabolism-the-case-of-fish-oil
#8
JOURNAL ARTICLE
Cennet Yildiz, Isabel Medina
Inefficient glucose metabolism and decreased ATP production in the brain are linked to ageing, cognitive decline, and neurodegenerative diseases (NDDs). This study employed thermodynamic analysis to assess the effect of fish oil supplementation on glucose metabolism in ageing brains. Data from previous studies on glucose metabolism in the aged human brain and grey mouse lemur brains were examined. The results demonstrated that Omega-3 fish oil supplementation in grey mouse lemurs increased entropy generation and decreased Gibbs free energy across all brain regions...
February 24, 2024: Nutrients
https://read.qxmd.com/read/38473136/influence-of-a-mixture-of-protein-hydrolysate-from-black-soldier-fly-larvae-and-schizochytrium-on-palatability-plasma-biochemistry-and-antioxidative-and-anti-inflammatory-capacity-in-cat-diets
#9
JOURNAL ARTICLE
You Li, Mingkang Liu, Yu Wei, Luyang Li, Deying Ma, Yuxiao Weng, Haifeng Wang, Xiao Xu
The objective of this research was to evaluate palatability, plasma biochemistry, antioxidative and anti-inflammatory capacity, and immune levels in cats by feeding supplementing inclusion of different levels of a mixture of protein hydrolysate from black soldier fly larvae and schizochytrium (BSFPs) in diets. In the feed experiment, a total of 24 adult cats (12 females and 12 males; BW: 3.02 ± 0.06 kg) were randomly divided into four groups: (1) diet with chicken and fish meal as primary protein resource (CON); (2) diet with 5% BSFPs replacing chicken meal, fish meal, chicken oil, and fish oil (5% BSFPs); (3) 10% BSFPs; and (4) 15% BSFPs...
February 28, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38470647/omega-3-fatty-acids-for-depression-in-the-elderly-and-patients-with-dementia-a-systematic-review-and-meta-analysis
#10
REVIEW
Yen-Yun Chang, Berne Ting, Daniel Tzu-Li Chen, Wei-Ti Hsu, Song-Chow Lin, Chun-Yen Kuo, Ming-Fu Wang
This study aimed to evaluate the efficacy of omega-3 fatty acid supplementation interventions in improving depression in patients with dementia. To achieve this objective, randomized controlled trials (RCTs) were identified from primary electronic databases, focusing on the relationship between omega-3 fatty acids and depression in patients with dementia. The primary outcome was the impact of omega-3 fatty acids on post-intervention depression in patients with dementia, with subgroup analyses conducted based on the type of intervention (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) combination), duration of intervention (3 months, 6 months, 12 months, ≥24 months), cognitive function (ranging from mild cognitive impairment (MCI) to severe dementia), and daily dosage (high, medium, low, applicable to both DHA and EPA)...
February 23, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38469864/dietary-intake-of-different-ratios-of-ara-dha-in-early-stages-and-its-impact-on-infant-development
#11
REVIEW
Lijiao Fan, Xincen Wang, Ignatius Man-Yau Szeto, Biao Liu, Andrew J Sinclair, Duo Li
Long-chain polyunsaturated fatty acids (LC-PUFAs), arachidonic acid (ARA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3) are essential in the development of infants. ARA and DHA from breast milk or infant formula are the main sources of access for infants to meet their physiological and metabolic needs. The ratio of ARA to DHA in breast milk varies among regions and different lactation stages. Different ratios of ARA and DHA mainly from algal oil, animal fat, fish oil, and microbial oil, are added to infant formula in different regions and infant age ranges...
March 12, 2024: Food & Function
https://read.qxmd.com/read/38465482/a-placebo-controlled-double-blind-study-evaluating-the-effect-of-orally-administered-polyunsaturated-fatty-acids-on-the-oclacitinib-dose-for-atopic-dogs
#12
JOURNAL ARTICLE
Laura Schäfer, Nina Thom
BACKGROUND: Supplementation of polyunsaturated fatty acids (PUFA) enables dose reduction of prednisolone and ciclosporin in canine atopic dermatitis (cAD). OBJECTIVE: To determine if oral administration of PUFA reduces the dose of oclacitinib in cAD. ANIMALS: Twenty-two client-owned dogs with cAD receiving oclacitinib. MATERIALS AND METHODS: Dogs received a fish oil product (PUFA) or paraffin oil (placebo) for 16 weeks...
March 11, 2024: Veterinary Dermatology
https://read.qxmd.com/read/38447232/weight-loss-induced-by-a-hypocaloric-diet-with-or-without-fish-oil-supplementation-re-established-iron-and-omega-3-fatty-acid-homeostasis-in-middle-aged-women-with-obesity-a-post-hoc-analysis-of-a-randomized-controlled-trial
#13
JOURNAL ARTICLE
Shih-Yi Huang, Noor Rohmah Mayasari, Te-Hsuan Tung, Wen-Ling Lin, Sung-Hui Tseng, Chun-Chao Chang, Hui-Yu Huang, Jung-Su Chang
OBJECTIVE: Middle-aged women with obesity are at increased risk of iron overload and iron disorder is known to disrupt n-3 polyunsaturated fatty acid homeostasis. We evaluated relationships between pretreatment hemoglobin and n-3 polyunsaturated fatty acid levels, and tested whether pretreatment hemoglobin contributed to inter-individual variability in weight loss with special focus on changes in body weight, iron and n-3 polyunsaturated fatty acid profiles. STUDY DESIGN: 117 middle and older aged women with obesity and more than two metabolic abnormalities were randomized to a 12-week hypocaloric diet without or with fish oil supplementation...
February 24, 2024: Maturitas
https://read.qxmd.com/read/38414488/revisiting-multi-omics-based-predictors-of-the-plasma-triglyceride-response-to-an-omega-3-fatty-acid-supplementation
#14
JOURNAL ARTICLE
Josiane Morin-Bernier, Juan de Toro-Martín, Valentin Barbe, Rodrigo San-Cristobal, Simone Lemieux, Iwona Rudkowska, Patrick Couture, Olivier Barbier, Marie-Claude Vohl
BACKGROUND: The aim of the present study was to identify the metabolomic signature of responders and non-responders to an omega-3 fatty acid (n-3 FA) supplementation, and to test the ability of a multi-omics classifier combining genomic, lipidomic, and metabolomic features to discriminate plasma triglyceride (TG) response phenotypes. METHODS: A total of 208 participants of the Fatty Acid Sensor (FAS). Study took 5 g per day of fish oil, providing 1.9-2.2 g eicosapentaenoic acid (EPA) and 1...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38405494/omega-3-enriched-and-oxidative-stable-mayonnaise-formulated-with-spray-dried-microcapsules-of-chia-and-fish-oil-blends
#15
JOURNAL ARTICLE
Muhammad Abdul Rahim, Muhammad Imran, Faima Atta Khan, Fahad Al-Asmari, Osama F Mosa, Riyadh S Almalki, Eliasse Zongo
There is a growing demand for nutritious food products that contain specific ingredients, such as long-chain polyunsaturated fatty acids (LCPUFAs). In the case of LCPUFAs, protection against lipid peroxidation is difficult, and microencapsulation emerges as an alternative. The aim of this research work is to develop mayonnaise containing spray-dried microcapsules (SDM). Fortified mayonnaise was developed using various treatments such as (T1 ) incorporating chia seed oil (CSO), (T2 ) incorporating fish oil (FO), (T3 ) incorporating blend of chia and fish oil, (T4 ) incorporating the SDM of CSO, (T5 ) incorporating the SDM of FO, and (T6 ) incorporating the SDM of chia and fish oil blend as well as controls...
February 20, 2024: ACS Omega
https://read.qxmd.com/read/38398823/nutritional-considerations-of-irish-performance-dietitians-and-nutritionists-in-concussion-injury-management
#16
JOURNAL ARTICLE
Emma Finnegan, Ed Daly, Lisa Ryan
Sport-related concussion incidence has increased in many team-based sports, such as rugby, Gaelic (camogie, hurling, football), and hockey. Concussion disrupts athletes' brain function, causing an "energy crisis" that requires energy and nutrient support to restore function and heal. Performance dietitians and nutritionists play a role in supporting athletes' post-injury nutritional demands. This study aimed to investigate Irish performance dietitians' and nutritionists' knowledge and implementation of nutritional strategies to manage and support athletes' recovery following concussion...
February 9, 2024: Nutrients
https://read.qxmd.com/read/38392798/morphological-changes-and-strong-cytotoxicity-in-yarrowia-lipolytica-by-overexpressing-delta-12-desaturase
#17
JOURNAL ARTICLE
Yufei Chang, Zhen Wang, Hequn Li, Wenrui Dang, Yuanda Song, Xinxin Kang, Huaiyuan Zhang
In this study, delta-12 desaturase was overexpressed in Yarrowia lipolytica using the single-copy integrative vector pINA1312 and multicopy integrative vector pINA1292, resulting in the engineered yeast strains 1312-12 and 1292-12, respectively. The content of intracellular linoleic acid (LA) in the 1292-12 strain was much higher than in the 1312-12 strain and the control group. One interesting finding was that the 1292-12 strain showed obvious changes in surface morphology. The 1292-12 colonies were much smaller and smoother, whereas their single cells became much larger compared to the control strain...
February 3, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38390371/combined-replacement-of-fishmeal-and-fish-oil-by-poultry-byproduct-meal-and-mixed-oil-effects-on-the-growth-performance-body-composition-and-muscle-quality-of-tiger-puffer
#18
JOURNAL ARTICLE
Lili Zhao, Lin Li, Feiran Zhang, Peng Li, Yanlu Li, Jian Liu, Yuliang Wei, Mengqing Liang, Qiang Ma, Houguo Xu
This study aimed to evaluate the effects of combined replacement of fishmeal (FM) and fish oil (FO) with poultry byproduct meal (PBM) and mixed oil (MO, poultry oil: coconut oil = 1 : 1) on growth performance, body composition and muscle quality of tiger puffer ( Takifugu rubripes ). Fish with an average initial body weight of 14.29 g were selected for the feeding experiment. FM accounting for 0%, 5%, and 10% of the diet was replaced by PBM. For each grade of FM replacement, 5% FO or MO was used as added oil...
2024: Aquaculture Nutrition
https://read.qxmd.com/read/38387522/toxicological-evaluation-of-a-fish-oil-concentrate-containing-very-long-chain-fatty-acids
#19
JOURNAL ARTICLE
Derek Tobin, Harald Svensen, Devanand Shanmugasundaram, Bente Ruyter, Iren Stoknes, Michael Dornish
Very long chain fatty acids (VLCFA) have a chain length ≥24 carbons. Fish contain low levels of these fatty acids. A commercial oil called EPAX® Evolve 05 with an up-concentration of VLCFAs of approximately 10 times, has been developed as a dietary supplement by Epax Norway AS. A series of toxicological studies were performed using mice and rats to determine the safety and toxicity of repeat dosing with a gavage administered VLCFA formulation. The results suggest transient lipid accumulation in kidneys and liver...
February 20, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38379273/an-analysis-of-omega-3-clinical-trials-and-a-call-for-personalized-supplementation-for-dementia-prevention
#20
REVIEW
Nicolás Castellanos-Perilla, Miguel Germán Borda, Dag Aarsland, George E Barreto
INTRODUCTION: Targeted interventions are needed to delay or prevent the onset of neurodegenerative diseases. Poor dietary habits are associated with cognitive decline, highlighting the benefits of a healthy diet with fish and polyunsaturated fatty acids (PUFAs). Intake of omega-3 PUFAs docosahexaenoic acid (DHA), α-linolenic acid (ALA) and eicosapentaenoic acid (EPA) is linked with healthy aging, cardiovascular benefits, and reduced risk of Alzheimer's disease. Although omega-3 has health benefits, its intake is often inadequate and insufficient in modern diets...
February 20, 2024: Expert Review of Neurotherapeutics
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