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diagnostic reference levels

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https://www.readbyqxmd.com/read/29162490/qualitative-and-quantitative-assessment-of-cartilage-degeneration-using-full-field-optical-coherence-tomography-ex-vivo
#1
R Pailhe, A Mounier, B Boisson, R C Rouchy, S Voros, E Chipon, I Boudry, M Medici, C Hughes, A Moreau-Gaudry
OBJECTIVE: The purpose of this study was to investigate the ability of full-field optical coherence tomography (FFOCT) to qualitatively and quantitatively evaluate cartilage degeneration using the qualitative evaluation of histology sections as the reference. DESIGN: 33 human knee cartilage samples of variable degeneration were included in the study. A closely matching histology and FFOCT image was acquired for each sample. The cartilage degeneration was qualitatively evaluated by assigning a grade to each histology and FFOCT image...
November 18, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29160230/paediatric-interventional-cardiology-in-costa-rica-diagnostic-reference-levels-and-estimation-of-population-dose
#2
Carlos Ubeda, Eliseo Vano, Luisa Salazar, Viviana Retana, Freddys Santos, Rafael Gutierrez, Carlos Manterola
The goal of the present study is to propose a set of national diagnostic reference levels (DRLs) for paediatric interventional cardiology (IC) procedures classified by age and weight in Costa Rica and to estimate the collective dose to the paediatric population deriving from these intervention practices. The data collection period was from May 2016 to May 2017. National DRLs were set as the third quartile of patient dose data distributions for kerma area-product (KAP) values. A sample of 154 paediatric IC procedures (collected in the national paediatric hospital with a single x-ray system) was used and divided into four age ranges and five weight ranges...
November 21, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29157674/circulating-concentrations-of-advanced-glycation-end-products-its-association-with-the-development-of-diabetes-mellitus
#3
Itzel Uribe Jiménez, Eulises Díaz-Díaz, Jorge Salmerón Castro, Julia Pérez Ramos, Mario Cárdenas León, José Antonio Alvarado Ríos, Juan Carlos Auriostigue Bautista, Ricardo Correa-Rotter, Carlos Alberto Aguilar Salinas, Fernando Larrea
BACKGROUND: Diabetes Mellitus (DM) is characterized by the production and accumulation of advanced glycation end products (AGEs), which are one of the key mechanisms in the development of its chronic complications. AIMS OF THE STUDY: To assess the serum AGEs concentration by a radioimmunoassay (RIA) developed in our laboratory, to establish reference values in healthy population and to evaluate the diagnostic potential of measuring longitudinal changes in circulating AGEs concentrations to predict the development of DM...
May 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29155984/cysteine-rich-angiogenic-inducer-61-cyr61-a-novel-soluble-biomarker-of-acute-myocardial-injury-improves-risk-stratification-after-acute-coronary-syndromes
#4
Roland Klingenberg, Soheila Aghlmandi, Christoph Liebetrau, Lorenz Räber, Baris Gencer, David Nanchen, David Carballo, Alexander Akhmedov, Fabrizio Montecucco, Stefan Zoller, Chad Brokopp, Dik Heg, Peter Jüni, Helena Marti Soler, Pedro-Manuel Marques-Vidal, Peter Vollenweider, Oliver Dörr, Nicolas Rodondi, François Mach, Stephan Windecker, Ulf Landmesser, Arnold von Eckardstein, Christian W Hamm, Christian M Matter, Thomas F Lüscher
Aims: We aimed to identify a novel biomarker involved in the early events leading to an acute coronary syndrome (ACS) and evaluate its role in diagnosis and risk stratification. Methods and results: Biomarker identification was based on gene expression profiling. In coronary thrombi of ACS patients, cysteine-rich angiogenic inducer 61 (Cyr61, CCN1) gene transcripts were highly up-regulated compared with peripheral mononuclear cells. In a murine ischaemia-reperfusion model (I/R), myocardial Cyr61 expression was markedly increased compared with the controls...
November 16, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29154571/taxometric-analyses-of-pedophilia-utilizing-self-report-behavioral-and-sexual-arousal-indicators
#5
Skye Stephens, Elisabeth Leroux, Tracey Skilling, James M Cantor, Michael C Seto
Pedophilia refers to the recurrent, intense sexual interest in prepubescent children who, by definition, have not developed any secondary sex characteristics. Researchers have begun to investigate whether persons with pedophilia are qualitatively different from those without pedophilia (pedophilia is a taxon) or if people vary in their level of sexual interest toward children (pedophilia is dimensional). Two relatively small studies have previously attempted to address this question, but produced conflicting results...
November 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29153064/-comparison-of-polymerase-chain-reaction-using-kinetoplast-dna-specific-primers-and-other-parasitological-methods-in-the-diagnosis-of-clinical-samples-of-suspected-patients-with-cutaneous-leishmaniasis-in-%C3%A5-anl%C3%A4-urfa
#6
Fadile Yıldız Zeyrek, Seray Töz, Fehmi Yüksel, Nevin Turgay, Yusuf Özbel
Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are seen endemically in Turkey and CL caused by Leishmania tropica is an important public health problem in southeastern as well as other regions of Turkey. The diagnosis has been usually made by clinical view of lesion and/or parasitologically using lesion aspiration smears. Histological examination does not, always reveal the parasite in the skin biopsy, particularly in chronic lesions. Besides this, due to CL infections caused by different species in endemic areas, diagnostic methods enabling species identification are in great need...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29148026/the-influence-of-hemodialysis-membrane-permeability-on-serum-procalcitonin-values-in-patients-on-maintenance-hemodialysis
#7
Taoufiq Aatif, Yassir Zajjari, Anas Jeaidi
BACKGROUND: Procalcitonin (PCT) has emerged as a marker of infection and it could be useful for detection of systemic bacterial infections in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD). The aim of this study was to assess the influence of HD membrane permeability to PCT serum levels in noninfected HD patients on maintenance HD. METHODS: In a prospective comparative study, we measured PCT serum levels and C reactive protein (CRP) before and after HD in 36 sessions (18 sessions of HD with low-flux = Group L; and 18 sessions with high flux membranes = Group H), in 18 chronic HD patients without history of infection...
November 9, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29136248/determination-of-national-diagnostic-reference-levels-in-computed-tomography-examinations-of-iran-by-a-new-quality-control-based-dose-survey-method
#8
Mehdi Sohrabi, Masoumeh Parsi, Fereidoun Mianji
National diagnostic reference levels (NDRLs) of Iran were determined for the four most common CT examinations including head, sinus, chest and abdomen/pelvis. A new 'quality control (QC)-based dose survey method', as developed by us, was applied to 157 CT scanners in Iran (2014-15) with different slice classes, models and geographic spread across the country. The NDRLs for head, sinus, chest and abdomen/pelvis examinations are 58, 29, 12 and 14 mGy for CTDIVol and 750, 300, 300 and 650 mGy.cm for DLP, respectively...
November 10, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29135908/evaluation-of-a-novel-immunoassay-for-lacosamide-therapeutic-drug-monitoring-comparison-with-a-liquid-chromatography-mass-spectrometry-assay
#9
Annachiara DʼUrso, Tiziano Ricotta, Ugo de Grazia
BACKGROUND: Monitoring serum levels of lacosamide, other than to establish individualized reference ranges may be helpful in several settings, including patients with liver and/or kidney failure or settings that may result in altered pharmacokinetic characteristics and to assess patients' compliance with therapy. In this study, the EurekaOne liquid chromatography-mass spectrometry (LC-MS/MS) method (in use method) and the ARK immunoassay method (new method) for lacosamide monitoring were compared...
December 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29134239/temporomandibular-joint-atlas-for-detection-and-grading-of-juvenile-idiopathic-arthritis-involvement-by-magnetic-resonance-imaging
#10
Christian J Kellenberger, Thitiporn Junhasavasdikul, Mirkamal Tolend, Andrea S Doria
Contrast-enhanced magnetic resonance imaging (MRI) is considered the diagnostic standard for identifying involvement of the temporomandibular joint by juvenile idiopathic arthritis. Early or active arthritis is shown as bone marrow oedema, joint effusion, synovial thickening and increased joint enhancement. Subsequent joint damage includes characteristic deformity of the mandibular condyle, bone erosion, disk abnormalities and short mandibular ramus due to impaired growth. In this pictorial essay, we illustrate normal MRI findings and growth-related changes of the temporomandibular joint in children...
November 13, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29130645/distributed-decision-making-in-action-diagnostic-imaging-investigations-within-the-bigger-picture
#11
Chandra R Makanjee, Anne-Marie Bergh, Willem A Hoffmann
INTRODUCTION: Decision making in the health care system - specifically with regard to diagnostic imaging investigations - occurs at multiple levels. Professional role players from various backgrounds are involved in making these decisions, from the point of referral to the outcomes of the imaging investigation. The aim of this study was to map the decision-making processes and pathways involved when patients are referred for diagnostic imaging investigations and to explore distributed decision-making events at the points of contact with patients within a health care system...
November 11, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29124374/complications-and-treatment-strategy-after-breast-augmentation-by-polyacrylamide-hydrogel-injection-summary-of-10-year-clinical-experience
#12
Rui Jin, Xusong Luo, Xiaoke Wang, Jie Ma, Fei Liu, Qun Yang, Jun Yang, Xi Wang
From 1997 to 2006, polyacrylamide hydrogel (PAAG) was approved for use in China as a permanent filler for breast augmentation, and it is estimated that 200,000 women have undergone PAAG injection since then. After injection, complications such as pain, mass, hematoma, asymmetry, migration, infection, and even cancer continue to emerge. Because of the potential toxicity and unstable nature of the material and the nonstandardized injection layers, complications after PAAG injection breast augmentation are often complex and difficult to treat...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29121500/validation-of-a-salmonella-loop-mediated-isothermal-amplification-assay-in-animal-food
#13
Kelly J Domesle, Qianru Yang, Thomas S Hammack, Beilei Ge
Loop-mediated isothermal amplification (LAMP) has emerged as a promising alternative to PCR for pathogen detection in food testing and clinical diagnostics. This study aimed to validate a Salmonella LAMP method run on both turbidimetry (LAMP I) and fluorescence (LAMP II) platforms in representative animal food commodities. The U.S. Food and Drug Administration (FDA)'s culture-based Bacteriological Analytical Manual (BAM) method was used as the reference method and a real-time quantitative PCR (qPCR) assay was also performed...
October 18, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29119649/prospective-multimodal-imaging-assessment-of-locally-advanced-cervical-cancer-patients-administered-by-chemoradiation-followed-by-radical-surgery-the-price-prospective-imaging-of-cervical-cancer-and-neoadjuvant-treatment-study-2-the-role-of-ultrasound-after
#14
Antonia Carla Testa, Francesca Moro, Tina Pasciuto, Maria Cristina Moruzzi, Alessia Di Legge, Gilda Fuoco, Rosa Autorino, Angela Collarino, Benedetta Gui, Gian Franco Zannoni, Antonietta Gambacorta, Maura Miccò, Vittoria Rufini, Giovanni Scambia, Gabriella Ferrandina
OBJECTIVE: To determine the diagnostic performance of two-dimensional ultrasound parameters, three-dimensional power Doppler and intravenous contrast enhanced indices in detecting residual disease in locally advanced cervical cancer patients triaged to neoadjuvant treatment followed by radical surgery. METHODS: Between October 2010 and June 2014, 108 women with histologically documented cervical cancer and FIGO stage IB2-IVA were screened and 88 of them were included in the final analysis...
November 8, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29117346/increasing-access-to-tuberculosis-services-in-ethiopia-findings-from-a-patient-pathway-analysis
#15
Lelisa Fekadu, Christy Hanson, Mike Osberg, Julia Makayova, Pia Mingkwan, Daniel Chin
Background: In Ethiopia, extensive scale-up of the availability of health extension workers (HEWs) at the community level has been credited with increased identification and referral of patients with presumptive tuberculosis, which has contributed to increased tuberculosis case notification and better treatment outcomes. However, nearly 30% of Ethiopia's estimated 191000 patients with tuberculosis remained unnotified in 2015. A better understanding of patient care-seeking practices may inform future government action to reach all patients with tuberculosis...
November 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29116438/staging-with-computed-tomography-of-patients-with-colon-cancer
#16
M L Malmstrøm, S Brisling, T W Klausen, A Săftoiu, T Perner, P Vilmann, I Gögenur
PURPOSE: Accurate staging of colonic cancer is important for patient stratification. We aimed to correlate the diagnostic accuracy of preoperative computed tomography (CT) with final histopathology as reference standard. METHODS: Data was collected retrospectively on 615 consecutive patients operated for colonic cancer. Evaluation was based upon T-stage. Patients were stratified into high-risk and low-risk groups, based on the extent of tumor invasion beyond the proper muscle layer of more or less than 5 mm...
November 7, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29102244/an-uhplc-ms-ms-method-for-simultaneous-quantification-of-human-amyloid-beta-peptides-a%C3%AE-1-38-a%C3%AE-1-40-and-a%C3%AE-1-42-in-cerebrospinal-fluid-using-micro-elution-solid-phase-extraction
#17
Ping-Ping Lin, Wei-Li Chen, Fei Yuan, Lei Sheng, Yu-Jia Wu, Wei-Wei Zhang, Guo-Qing Li, Hong-Rong Xu, Xue-Ning Li
Amyloid beta (Aβ) peptides in cerebrospinal fluid are extensively estimated for identification of Alzheimer's disease (AD) as diagnostic biomarkers. Unfortunately, their pervasive application is hampered by interference from Aβ propensity of self-aggregation, nonspecifically bind to surfaces and matrix proteins, and by lack of quantitive standardization. Here we report on an alternative Ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for simultaneous measurement of human amyloid beta peptides Aβ1-38, Aβ1-40 and Aβ1-42 in cerebrospinal fluid (CSF) using micro-elution solid phase extraction (SPE)...
October 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29101020/angiography-based-quantitative-flow-ratio-for-online-assessment-of-coronary-stenosis-favor-ii-china-study
#18
Bo Xu, Shengxian Tu, Shubin Qiao, Xinkai Qu, Yundai Chen, Junqing Yang, Lijun Guo, Zhongwei Sun, Zehang Li, Feng Tian, Weiyi Fang, Jiyan Chen, Wei Li, Changdong Guan, Niels R Holm, William Wijns, Shengshou Hu
OBJECTIVES: To assess the diagnostic performance of quantitative flow ratio (QFR) for diagnosis of hemodynamically-significant coronary stenosis defined by fractional flow reserve (FFR) ≤0.80. BACKGROUND: QFR is a novel angiography-based method for deriving FFR without pressure wire or induction of hyperemia. The accuracy of QFR when assessed online in the catheterization laboratory has not been adequately examined to date. METHODS: This prospective, multicenter trial enrolled patients who had at least one lesion with diameter stenosis of 30-90% and reference diameter ≥ 2mm by visual estimation...
October 20, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29100713/a-hrm-assay-for-identification-of-low-level-braf-v600e-and-v600k-mutations-using-the-cadma-principle-in-ffpe-specimens
#19
Claudia Huebner, Remeny Weber, Richard Lloydd
Melanoma patients with BRAF V600E and V600K mutations show complete or partial response to vemurafenib. Detection assays often scan for the common V600E mutation rather than the rare V600K variant, although this mutation can be found in a high proportion of melanoma patients in the South Pacific. Herein, we describe a BRAF high resolution melting (HRM) assay that can differentiate low level of V600E and V600K mutations using formalin fixed, paraffin embedded (FFPE) reference standards for assay validation. The assay is based on the competitive amplification of differentially melting amplicons (CADMA principle) and has a limit of detection of 0...
October 31, 2017: Pathology
https://www.readbyqxmd.com/read/29098167/mesh-to-raster-region-of-interest-based-nonrigid-registration-of-multimodal-images
#20
Rosalia Tatano, Benjamin Berkels, Thomas M Deserno
Region of interest (RoI) alignment in medical images plays a crucial role in diagnostics, procedure planning, treatment, and follow-up. Frequently, a model is represented as triangulated mesh while the patient data is provided from computed axial tomography scanners as pixel or voxel data. Previously, we presented a 2-D method for curve-to-pixel registration. This paper contributes (i) a general mesh-to-raster framework to register RoIs in multimodal images; (ii) a 3-D surface-to-voxel application, and (iii) a comprehensive quantitative evaluation in 2-D using ground truth (GT) provided by the simultaneous truth and performance level estimation (STAPLE) method...
October 2017: Journal of Medical Imaging
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