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https://www.readbyqxmd.com/read/28929581/gain-of-function-mutation-in-ptpn11-in-histiocytic-sarcomas-of-bernese-mountain-dogs
#1
T Thaiwong, S Sirivisoot, M Takada, V Yuzbasiyan-Gurkan, M Kiupel
Histiocytic sarcoma (HS) is an aggressive malignant neoplasm of dendritic cell origin that is common in certain breeds of dogs. High prevalence of fatal, disseminated HS has been described in Bernese Mountain Dogs (BMDs). Support for genetic predisposition to develop HS has been presented in several studies, but to date, causative genetic events have not been reported. In addition, no driver mutations have been identified in tumours. Recently, E76K gain-of-function mutation in SHP2 encoded by the PTPN11 gene has been described in human histiocytic malignancies...
September 20, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28861810/profiling-methyl-jasmonate-responsive-transcriptome-for-understanding-induced-systemic-resistance-in-whitebark-pine-pinus-albicaulis
#2
Jun-Jun Liu, Holly Williams, Xiao Rui Li, Anna W Schoettle, Richard A Sniezko, Michael Murray, Arezoo Zamany, Gary Roke, Hao Chen
RNA-seq analysis on whitebark pine needles demonstrated that methyl jasmonate (MeJA)-triggered transcriptome re-programming substantially overlapped with defense responses against insects and fungal pathogens in Pinus species, increasing current knowledge regarding induced systemic resistance (ISR) to pathogens and pests in whitebark pine. Many whitebark pine populations are in steep decline due to high susceptibility to mountain pine beetle and the non-native white pine blister rust (WPBR). Resistance, including induced systemic resistance (ISR), is not well characterized in whitebark pine, narrowing the current options for increasing the success of restoration and breeding programs...
August 31, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28771456/notes-from-the-field-preliminary-results-after-implementation-of-a-universal-treatment-program-test-and-start-for-persons-living-with-hiv-infection-lesotho-october-2015-february-2017
#3
Amee M Schwitters
Lesotho, a small, mountainous country completely surrounded by the Republic of South Africa, has a population of approximately 2 million persons with an estimated gross national income of $1,280 per capita; 73% of the population resides in rural areas (1). Lesotho has a generalized human immunodeficiency virus (HIV) epidemic (2). In 2014, the prevalence of HIV infection among persons aged 15-49 years was 24.6%, with an incidence of 1.9 new infections per 100 person-years of exposure (3). As the leading cause of premature death, HIV/AIDS (acquired immunodeficiency syndrome) has contributed to Lesotho's reporting the shortest life expectancy at birth among 195 countries and territories (4)...
August 4, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28762204/sentinel-lymph-node-characterization-with-a-dual-targeted-molecular-ultrasound-contrast-agent
#4
Kibo Nam, Maria Stanczak, Flemming Forsberg, Ji-Bin Liu, John R Eisenbrey, Charalambos C Solomides, Andrej Lyshchik
PURPOSE: The purpose of this study was to assess the performance of molecular ultrasound with dual-targeted microbubbles to detect metastatic disease in the sentinel lymph nodes (SLNs) in swine model of naturally occurring melanoma. The SLN is the first lymph node in the lymphatic chain draining primary tumor, and early detection of metastatic SLN involvement is critical in the appropriate management of melanoma. PROCEDURE: Nine Sinclair swine (weight 3-7 kg; Sinclair BioResources, Columbia, MO, USA) with naturally occurring melanoma were examined...
July 31, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28733592/machine-learning-model-analysis-of-breeding-habitats-for-the-black-necked-crane-in-central-asian-uplands-under-anthropogenic-pressures
#5
Xuesong Han, Yumin Guo, Chunrong Mi, Falk Huettmann, Lijia Wen
The black-necked crane (Grus nigricollis) is the only alpine crane species and is endemic to the Tibetan Plateau. The breeding habitats of this species are poorly understood, which greatly hampers practical research and conservation work. Using machine learning methods and the best-available data from our 7,000-kilometer mega-transect survey and open access data, we built the first species distribution model (SDM) to analyze the black-necked crane's breeding habitats. Our model showed that current conservation gaps account for 26...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28706209/mountain-gorilla-lymphocryptovirus-has-epstein-barr-virus-like-epidemiology-and-pathology-in-infants
#6
Tierra Smiley Evans, Linda J Lowenstine, Kirsten V Gilardi, Peter A Barry, Benard J Ssebide, Jean Felix Kinani, Fred Nizeyimana, Jean Bosco Noheri, Michael R Cranfield, Antoine Mudakikwa, Tracey Goldstein, Jonna A K Mazet, Christine Kreuder Johnson
Epstein-Barr virus (EBV) infects greater than 90% of humans, is recognized as a significant comorbidity with HIV/AIDS, and is an etiologic agent for some human cancers. The critically endangered mountain gorilla population was suspected of infection with an EBV-like virus based on serology and infant histopathology similar to pulmonary reactive lymphoid hyperplasia (PRLH), a condition associated with EBV in HIV-infected children. To further examine the presence of EBV or an EBV-like virus in mountain gorillas, we conducted the first population-wide survey of oral samples for an EBV-like virus in a nonhuman great ape...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28684588/dietary-nitrate-supplementation-increases-acute-mountain-sickness-severity-and-sense-of-effort-during-hypoxic-exercise
#7
Gabriella M K Rossetti, Jamie Hugo Macdonald, Lee J Wylie, Samuel J Little, Victoria Newton, Benjamin Wood, Kieran A Hawkins, Rhys Beddoe, Hannah E Davies, Samuel James Oliver
Dietary nitrate supplementation enhances sea level performance and may ameliorate hypoxemia at high altitude. However, nitrate may exacerbate acute mountain sickness (AMS), specifically headache. This study investigated the effect of nitrate supplementation on AMS symptoms and exercise responses with 6h hypoxia. Twenty recreationally-active men (mean(SD): age 22(4) years, V̇O2max 51(6) mL·min-1·kg-1) completed this randomized double-blinded placebo-controlled crossover study. Twelve participants were classified as AMS- based on Environmental Symptom Questionnaire (AMS-C) score <0...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28624083/effect-of-the-type-of-brewing-water-on-the-chemical-composition-sensory-quality-and-antioxidant-capacity-of-chinese-teas
#8
Yong-Quan Xu, Chun Zou, Ying Gao, Jian-Xin Chen, Fang Wang, Gen-Sheng Chen, Jun-Feng Yin
The physicochemical characteristics, sensory quality, and antioxidant activity of tea infusions prepared with purified water (PW), mineral water (MW), mountain spring water (MSW), and tap water (TW) from Hangzhou were investigated. The results showed that the taste quality, catechin concentration, and antioxidant capacity of green, oolong, and black tea infusions prepared using MW and TW were significantly lower than those prepared using PW. Extraction of catechins and caffeine was reduced with high-conductivity water, while high pH influenced the stability of catechins...
December 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28610249/comparative-morphological-and-molecular-taxonomic-study-of-six-i-achaeta%C3%A2-i-species-clitellata-enchytraeidae-with-the-description-of-a-new-i-achaeta-i-species-from-k%C3%A5-szeg-mountains-hungary
#9
Klára Dózsa-Farkas, Tamás Felföldi
Five Achaeta species (A. affinis, A. bohemica sensu stricto, A. camerani, A. cf. danica, A. unibulba) and a new species, described here as A. tothi sp. n., were found during the investigation of the enchytraeid fauna of western Hungary (Őrség National Park and Kőszeg Mts.). Comparative morphological and molecular taxonomic investigations were performed with several individuals representing these six Achaeta species. A detailed description of the new species is given, and we also present some additional morphological data and photos about the other five Achaeta species...
June 2, 2017: Zootaxa
https://www.readbyqxmd.com/read/28606208/medical-requirements-during-a-natural-disaster-a-case-study-on-whatsapp-chats-among-medical-personnel-during-the-2015-nepal-earthquake
#10
Moumita Basu, Saptarshi Ghosh, Arnab Jana, Somprakash Bandyopadhyay, Ravikant Singh
OBJECTIVE: The objective of this study was to explore a log of WhatsApp messages exchanged among members of the health care group Doctors For You (DFY) while they were providing medical relief in the aftermath of the Nepal earthquake in April 2015. Our motivation was to identify medical resource requirements during a disaster in order to help government agencies and other responding organizations to be better prepared in any upcoming disaster. METHODS: A large set of WhatsApp (WhatsApp Inc, Mountain View, CA) messages exchanged among DFY members during the Nepal earthquake was collected and analyzed to identify the medical resource requirements during different phases of relief operations...
June 13, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28593682/interactive-pediatric-emergency-checklists-to-the-palm-of-your-hand-how-the-pedi-crisis-app-traveled-around-the-world
#11
Jorge A Gálvez, Justin L Lockman, Laura E Schleelein, Allan F Simpao, Luis M Ahumada, Bryan A Wolf, Maully J Shah, Eugenie Heitmiller, Mohamed Rehman
BACKGROUND: Cognitive aids help clinicians manage critical events and have been shown to improve outcomes by providing critical information at the point of care. Critical event guidelines, such as the Society of Pediatric Anesthesia's Critical Events Checklists described in this article, can be distributed globally via interactive smartphone apps. From October 1, 2013 to January 1, 2014, we performed an observational study to determine the global distribution and utilization patterns of the Pedi Crisis cognitive aid app that the Society for Pediatric Anesthesia developed...
June 7, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28577258/-beet-ing-the-mountain-a-review-of-the-physiological-and-performance-effects-of-dietary-nitrate-supplementation-at-simulated-and-terrestrial-altitude
#12
Oliver Michael Shannon, Kerry McGawley, Linn Nybäck, Lauren Duckworth, Matthew John Barlow, David Woods, Mario Siervo, John Paul O'Hara
Exposure to altitude results in multiple physiological consequences. These include, but are not limited to, a reduced maximal oxygen consumption, drop in arterial oxygen saturation, and increase in muscle metabolic perturbations at a fixed sub-maximal work rate. Exercise capacity during fixed work rate or incremental exercise and time-trial performance are also impaired at altitude relative to sea level. Recently, dietary nitrate (NO3(-)) supplementation has attracted considerable interest as a nutritional aid during altitude exposure...
June 2, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28576950/retrospective-case-reports-of-two-central-north-carolina-residents-frequency-of-tick-bites-and-associated-illnesses-2001-2014
#13
Marcia E Herman-Giddens, D Marcus Herman-Giddens
BACKGROUND Tick bites are a source of illness and disease agents that may lead to morbidity and occasional fatalities in North Carolina. Public health interest in tick-borne illness and disease has increased due to continuing discoveries of tick-borne diseases and their increasing geographic spread and disease incidence. There are no data published on lay individuals with cumulative tick bites and associated illnesses over a period of years.METHODS We learned of a married couple living on a central North Carolina property who had used reasonable bite prevention methods, kept attached ticks after removal, and recorded dates and related illness records from 2001-2014...
May 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28535588/pedogenic-knowledge-aided-modelling-of-soil-inorganic-carbon-stocks-in-an-alpine-environment
#14
Ren-Min Yang, Fan Yang, Fei Yang, Lai-Ming Huang, Feng Liu, Jin-Ling Yang, Yu-Guo Zhao, De-Cheng Li, Gan-Lin Zhang
Accurate estimation of soil carbon is essential for accounting carbon cycling on the background of global environment change. However, previous studies made little contribution to the patterns and stocks of soil inorganic carbon (SIC) in large scales. In this study, we defined the structure of the soil depth function to fit vertical distribution of SIC based on pedogenic knowledge across various landscapes. Soil depth functions were constructed from a dataset of 99 soil profiles in the alpine area of the northeastern Tibetan Plateau...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28509579/findings-of-cognitive-impairment-at-high-altitude-relationships-to-acetazolamide-use-and-acute-mountain-sickness
#15
Lara Phillips, Buddha Basnyat, Yuchiao Chang, Erik R Swenson, N Stuart Harris
Phillips, Lara, Buddha Basnyat, Yuchiao Chang, Erik R. Swenson, and N. Stuart Harris. Findings of cognitive impairment at high altitude: relationships to acetazolamide use and acute mountain sickness. High Alt Med Biol. 18:121-127, 2017. OBJECTIVE: Acute mountain sickness (AMS) is defined by patient-reported symptoms using the Lake Louise Score (LLS), which provides limited insight into any possible underlying central nervous system (CNS) dysfunction. Some evidence suggests AMS might coexist with altered neural functioning...
June 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28481626/retinal-hemorrhage-in-a-high-altitude-aid-post-volunteer-doctor-a-case-report
#16
Sanjeeb Sudarshan Bhandari, Pranawa Koirala, Nirajan Regmi, Sushil Pant
Bhandari, Sanjeeb Sudarshan, Pranawa Koirala, Nirajan Regmi, and Sushil Pant. Retinal hemorrhage in a high-altitude aid post volunteer doctor: a case report. High Alt Med Biol. 18: 285-287, 2017.-High-altitude retinal hemorrhages (HARHs) are seen at altitudes more than 3000 m, are usually multiple, flame shaped, and adjacent to blood vessels. Development near the macula causes blurring of vision, otherwise, they are symptomless and self-limiting. They often develop during the first few days after ascent to high altitude and subjects often suffer from acute mountain sickness (AMS) or high-altitude cerebral edema (HACE)...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28395094/mountain-medical-kits-epidemiology-based-recommendations-and-analysis-of-medical-supplies-carried-by-mountain-climbers-in-colorado
#17
William E Brandenburg, Brian W Locke
Objective: : To provide medical kit recommendations for short mountain wilderness recreation trips (hiking, trekking, backpacking, mountaineering etc.) based on the epidemiology of injury and illness sustained and best treatment guidelines. Additionally, to compare these recommendations to the medical kit contents of mountain climbers in Colorado. Methods: : A primary literature review concerning the epidemiology of injury and illness in mountain wilderness settings was performed...
March 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28394182/medex2015-greater-sea-level-fitness-is-associated-with-lower-sense-of-effort-during-himalayan-trekking-without-worse-acute-mountain-sickness
#18
Gabriella M K Rossetti, Jamie H Macdonald, Matthew Smith, Anna R Jackson, Nigel Callender, Hannah K Newcombe, Heather M Storey, Sebastian Willis, Jojanneke van den Beukel, Jonathan Woodward, James Pollard, Benjamin Wood, Victoria Newton, Jana Virian, Owen Haswell, Samuel J Oliver
Rossetti, Gabriella M.K., Jamie H. Macdonald, Matthew Smith, Anna R. Jackson, Nigel Callender, Hannah K. Newcombe, Heather M. Storey, Sebastian Willis, Jojanneke van den Beukel, Jonathan Woodward, James Pollard, Benjamin Wood, Victoria Newton, Jana Virian, Owen Haswell, and Samuel J. Oliver. MEDEX2015: Greater sea-level fitness is associated with lower sense of effort during Himalayan trekking without worse acute mountain sickness. High Alt Med Biol. 18:152-162, 2017.-This study examined the complex relationships of fitness and hypoxic sensitivity with submaximal exercise responses and acute mountain sickness (AMS) at altitude...
June 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28183123/a-new-brachypterous-species-of-i-phoberus-i-macleay-coleoptera-trogidae-and-status-changes-of-species-in-the-east-african-i-p-nigrociliatus-i-group
#19
Werner P Strümpher, Clarke H Scholtz
A new brachypterous species, Phoberus nyikanus Strümpher (Coleoptera: Trogidae), is described from Malawi. In addition, three status changes are proposed: Phoberus nigrociliatus (Kolbe) from the Ethiopian highlands, P. nyansanus (Haaf) from central East Africa, and P. nyassicus (Haaf) from southern Tanzanian mountains are elevated to species level. A key is provided to aid in the identification of members of the P. nigrociliatus group, and the species in the group are illustrated by photographs. This brings the total number of species in the genus to 44...
January 6, 2017: Zootaxa
https://www.readbyqxmd.com/read/28165424/changbai-mountain-ginseng-panax-ginseng-c-a-mey-extract-supplementation-improves-exercise-performance-and-energy-utilization-and-decreases-fatigue-associated-parameters-in-mice
#20
Guo-Dong Ma, Chun-Hui Chiu, Yi-Ju Hsu, Chien-Wen Hou, Yi-Ming Chen, Chi-Chang Huang
Changbai Mountain Ginseng (CMG, Panax ginseng C.A. Mey) is a traditional medicine commonly found in Northeast China and grows at elevations of 2000 m or higher in the Changbai Mountain Range. CMG, considered to be a "buried treasure medicine", is priced higher than other types of ginseng. However, few studies have demonstrated the effects of CMG supplementation on exercise performance, physical fatigue, and the biochemical profile. The major compound of CMG extract was characterized by electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS)...
February 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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