Xiaocui Zheng, Xinjing Wang, Xi Cheng, Zhaoyuan Liu, Yujia Yin, Xiaoduan Li, Zhihao Huang, Ziliang Wang, Wei Guo, Florent Ginhoux, Ziyi Li, Zemin Zhang, Xipeng Wang
Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC ecosystem with five tumor-relevant sites, including omentum metastasis and malignant ascites. Our data reveal the potential roles of ascites-enriched memory T cells as a pool for tumor-infiltrating exhausted CD8+ T cells and T helper 1-like cells. Moreover, tumor-enriched macrophages exhibited a preference for monocyte-derived ontogeny, whereas macrophages in ascites were more of embryonic origin...
August 2023: Nature Cancer