keyword
Keywords Macrophage, omentum, ovarian c...

Macrophage, omentum, ovarian cancer

https://read.qxmd.com/read/37605299/omentum-provides-a-special-cell-microenvironment-for-ovarian-cancer
#1
REVIEW
Zeying Li, Xiaoling Fang, Sixue Wang
BACKGROUND: Ovarian cancer seriously threatens women's health because of its poor prognosis and high mortality. Due to the lack of efficient early detection and screening methods, when patients seek doctors' help with complaints of abdominal distension, back pain and other nonspecific signs, the clinical results always hint at the widespread metastasis of disease. When referring to the metastasis of this disease, the omentum always takes precedence. RECENT FINDINGS: The distinguishing feature of the omentum is adipose tissue, which satisfies the energy demand of cancer cells and supplies a more aggressive environment for ovarian cancer cells...
August 21, 2023: Cancer reports
https://read.qxmd.com/read/37488416/single-cell-analyses-implicate-ascites-in-remodeling-the-ecosystems-of-primary-and-metastatic-tumors-in-ovarian-cancer
#2
JOURNAL ARTICLE
Xiaocui Zheng, Xinjing Wang, Xi Cheng, Zhaoyuan Liu, Yujia Yin, Xiaoduan Li, Zhihao Huang, Ziliang Wang, Wei Guo, Florent Ginhoux, Ziyi Li, Zemin Zhang, Xipeng Wang
Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC ecosystem with five tumor-relevant sites, including omentum metastasis and malignant ascites. Our data reveal the potential roles of ascites-enriched memory T cells as a pool for tumor-infiltrating exhausted CD8+ T cells and T helper 1-like cells. Moreover, tumor-enriched macrophages exhibited a preference for monocyte-derived ontogeny, whereas macrophages in ascites were more of embryonic origin...
August 2023: Nature Cancer
https://read.qxmd.com/read/37345662/normal-saline-remodels-the-omentum-and-stimulates-its-receptivity-for-transcoelomic-metastasis
#3
JOURNAL ARTICLE
Hironari Akasaka, WonJae Lee, Song Yi Ko, Ernst Lengyel, Honami Naora
The omentum contains immune cell structures called milky spots that are niches for transcoelomic metastasis. It is difficult to remove the omentum completely, and there are no effective strategies to minimize the risk of colonization of preserved omental tissues by cancer cells that circulate in the peritoneal fluid. Normal saline is commonly administered into the peritoneal cavity for diagnostic and intraoperative lavage. Here we show that normal saline, when administered into the peritoneal cavity of mice, is prominently absorbed by the omentum, exfoliates its mesothelium, and induces expression of CX3CL1, the ligand for CX3CR1, within and surrounding the omental vasculature...
June 22, 2023: JCI Insight
https://read.qxmd.com/read/37180125/intraperitoneal-metastasis-of-ovarian-cancer-new-insights-on-resident-macrophages-in-the-peritoneal-cavity
#4
REVIEW
Taito Miyamoto, Brennah Murphy, Nan Zhang
Ovarian cancer metastasis occurs primarily in the peritoneal cavity. Orchestration of cancer cells with various cell types, particularly macrophages, in the peritoneal cavity creates a metastasis-favorable environment. In the past decade, macrophage heterogeneities in different organs as well as their diverse roles in tumor settings have been an emerging field. This review highlights the unique microenvironment of the peritoneal cavity, consisting of the peritoneal fluid, peritoneum, and omentum, as well as their own resident macrophage populations...
2023: Frontiers in Immunology
https://read.qxmd.com/read/36785673/-ptgis-may-be-a-predictive-marker-for-ovarian-cancer-by-regulating-fatty-acid-metabolism
#5
JOURNAL ARTICLE
Xiaoqing Wu, Wenping Lu, Chaojie Xu, Cuihong Jiang, Weixuan Zhang, Dongni Zhang, Shasha Cui, Zhili Zhuo, Yongjia Cui, Heting Mei, Ya'nan Wang, Chen Li
BACKGROUND: Ovarian cancer tends to metastasize to the omentum, which is an organ mainly composed of adipose tissue. Many studies have found that fatty acid metabolism is related to the occurrence and metastasis of cancers. Therefore, it is possible that fatty acid metabolism-related genes (FAMRG) affect the prognosis of ovarian cancer patients. METHODS: First, profiles of ovarian cancer and normal ovarian tissue transcriptomes were acquired from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases...
2023: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/36477408/laminins-in-tumor-derived-exosomes-upregulated-by-ets1-reprogram-omental-macrophages-to-promote-omental-metastasis-of-ovarian-cancer
#6
JOURNAL ARTICLE
Haiyang Li, Cheng Zeng, Chang Shu, Yuanyuan Cao, Wengui Shao, Mengjie Zhang, Hongyong Cao, Shuli Zhao
Tumor-derived exosomes participate in omental metastatic colonization of ovarian cancer by inducing an adaptive response in the tumor microenvironment. However, cell-cell communication via exosomes between primary tumor cells and the microenvironment of distant omentum and the mechanism of pre-metastatic niche formation are poorly understood. Here, we demonstrated that ETS1-overexpressing ovarian cancer cells secreted larger exosomes with higher laminin levels. In addition, ovarian cancer exosomes could be taken up by omental macrophages through integrin and laminin interaction...
December 7, 2022: Cell Death & Disease
https://read.qxmd.com/read/35964998/omentum-friend-or-foe-in-ovarian-cancer-immunotherapy
#7
JOURNAL ARTICLE
Ángela Bella, Leire Arrizabalaga, Claudia Augusta Di Trani, Myriam Fernández-Sendin, Alvaro Teijeira, Joan Salvador Russo-Cabrera, Ignacio Melero, Pedro Berraondo, Fernando Aranda
Ovarian cancer often spreads out of the ovary before a patient is diagnosed and is the deadliest gynecological malignancy. The aggressiveness of ovarian cancer is determined by the progression in the form of peritoneal carcinomatosis, a stage with a poor prognosis and an untreatable condition in most patients. One of the first tumor nests or the origin of metastasis in the peritoneal cavity is the omentum. The omentum contains immune aggregates, called milky spots, embedded in adipose tissue, which support tumor growth by various mechanisms, including immunosuppressive immune cells and metabolic functions...
2022: International Review of Cell and Molecular Biology
https://read.qxmd.com/read/35894484/the-role-of-selected-molecular-factors-in-ovarian-cancer-metastasis
#8
JOURNAL ARTICLE
Anna Markowska, Wlodzimierz Sawicki, Jakub Zurawski, Joanna Fechner, Janina Markowska
The main reason for treatment failure in ovarian cancer is chemoresistance and the presence of metastasis. Ascites, which allows the physical movement of cancer cells, the lymphovascular pathway, and several molecular factors and signalling axes, are involved in metastasis. Ascites, with the involvement of cytokines and chemokines, MAPK/STAT1 and NOTCH as well as CXCL12/CXCR4 signaling pathways and circulating anoikis induces cancer dissemination, in particular to the peritoneum and omentum. The spread of lymphatic and bloodstream cancer cells is a multi-stage process...
July 27, 2022: Ginekologia Polska
https://read.qxmd.com/read/34677277/omental-macrophagic-crown-like-structures-are-associated-with-poor-prognosis-in-advanced-stage-serous-ovarian-cancer
#9
JOURNAL ARTICLE
Yu-Ling Liang, Chang-Ni Lin, Hsing-Fen Tsai, Pei-Ying Wu, Sheng-Hsiang Lin, Tse-Ming Hong, Keng-Fu Hsu
The tumor microenvironment is a well-recognized framework in which immune cells present in the tumor microenvironment promote or inhibit cancer formation and development. A crown-like structure (CLS) has been reported as a dying or dead adipocyte surrounded by a 'crown' of macrophages within adipose tissue, which is a histologic hallmark of the inflammatory process in this tissue. CLSs have also been found to be related to formation, progression and prognosis of some types of cancer. However, the presence of CLSs in the omentum of advanced-stage high-grade serous ovarian carcinoma (HGSOC) has not been thoroughly investigated...
October 19, 2021: Current Oncology
https://read.qxmd.com/read/34440886/mesenchymal-stem-cells-in-adipose-tissue-and-extracellular-vesicles-in-ovarian-cancer-patients-a-bridge-toward-metastatic-diffusion-or-a-new-therapeutic-opportunity
#10
REVIEW
Gabriele Storti, Maria Giovanna Scioli, Bong-Sung Kim, Sonia Terriaca, Elena Fiorelli, Augusto Orlandi, Valerio Cervelli
Ovarian cancer is one of the deadliest malignancies among women. Approximately 75% of the patients with ovarian cancer are diagnosed with advanced disease that already has metastasis, particularly to the omentum. The omentum constitutes the ideal soil for ovarian cancer metastasis due to a complex intraperitoneal milieu that favors and supports the whole metastatic process. Adipose-derived stem/stromal cells (ADSCs) are part of this microenvironment and foster tumor progression via sustained paracrine secretion, including extracellular vesicles (EVs)...
August 18, 2021: Cells
https://read.qxmd.com/read/34038734/characterizing-the-tumor-microenvironment-of-metastatic-ovarian-cancer-by-single-cell-transcriptomics
#11
JOURNAL ARTICLE
Susan Olalekan, Bingqing Xie, Rebecca Back, Heather Eckart, Anindita Basu
Understanding the cellular composition of the tumor microenvironment and the interactions of the cells is essential to the development of successful immunotherapies in cancer. We perform single-cell RNA sequencing (scRNA-seq) of 9,885 cells isolated from the omentum in 6 patients with ovarian cancer and identify 9 major cell types, including cancer, stromal, and immune cells. Transcriptional analysis of immune cells stratifies our patient samples into 2 groups: (1) high T cell infiltration (high Tinf ) and (2) low T cell infiltration (low Tinf )...
May 25, 2021: Cell Reports
https://read.qxmd.com/read/33799991/preclinical-verification-of-the-efficacy-and-safety-of-aqueous-plasma-for-ovarian-cancer-therapy
#12
JOURNAL ARTICLE
Kae Nakamura, Nobuhisa Yoshikawa, Yuko Mizuno, Miwa Ito, Hiromasa Tanaka, Masaaki Mizuno, Shinya Toyokuni, Masaru Hori, Fumitaka Kikkawa, Hiroaki Kajiyama
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The major cause of EOC's lethality is that intraperitoneal recurrence occurs with high frequency due to occult metastasis. We had demonstrated that plasma-activated medium (PAM) exerts a metastasis-inhibitory effect on ovarian cancer in vitro and in vivo. Here we investigated how PAM inhibits intraperitoneal metastasis. We studied PAM's inhibition of micro-dissemination onto the omentum by performing in vivo imaging in combination with a sequential histological analysis...
March 7, 2021: Cancers
https://read.qxmd.com/read/33467127/possible-role-of-metformin-as-an-immune-modulator-in-the-tumor-microenvironment-of-ovarian-cancer
#13
REVIEW
Faye K Tsogas, Daniel Majerczyk, Peter C Hart
Growing evidence suggests that the immune component of the tumor microenvironment (TME) may be highly involved in the progression of high-grade serous ovarian cancer (HGSOC), as an immunosuppressive TME is associated with worse patient outcomes. Due to the poor prognosis of HGSOC, new therapeutic strategies targeting the TME may provide a potential path forward for preventing disease progression to improve patient survival. One such postulated approach is the repurposing of the type 2 diabetes medication, metformin, which has shown promise in reducing HGSOC tumor progression in retrospective epidemiological analyses and through numerous preclinical studies...
January 16, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/32963283/omental-macrophages-secrete-chemokine-ligands-that-promote-ovarian-cancer-colonization-of-the-omentum-via-ccr1
#14
JOURNAL ARTICLE
Venkatesh Krishnan, Supreeti Tallapragada, Bruce Schaar, Kalika Kamat, Anita M Chanana, Yue Zhang, Sonia Patel, Vinita Parkash, Carrie Rinker-Schaeffer, Ann K Folkins, Erinn B Rankin, Oliver Dorigo
The omentum is the most common site of ovarian cancer metastasis. Immune cell clusters called milky spots are found throughout the omentum. It is however unknown if these immune cells contribute to ovarian cancer metastasis. Here we report that omental macrophages promote the migration and colonization of ovarian cancer cells to the omentum through the secretion of chemokine ligands that interact with chemokine receptor 1 (CCR1). We found that depletion of macrophages reduces ovarian cancer colonization of the omentum...
September 22, 2020: Communications Biology
https://read.qxmd.com/read/32456078/the-role-of-tumor-associated-macrophages-in-the-progression-and-chemoresistance-of-ovarian-cancer
#15
REVIEW
Marek Nowak, Magdalena Klink
Tumor-associated macrophages (TAMs) constitute the main population of immune cells present in the ovarian tumor microenvironment. These cells are characterized by high plasticity and can be easily polarized by colony-stimulating factor-1, which is released by tumor cells, into an immunosuppressive M2-like phenotype. These cells are strongly implicated in both the progression and chemoresistance of ovarian cancer. The main pro-tumoral function of M2-like TAMs is the secretion of a variety of cytokines, chemokines, enzymes and exosomes that reach microRNAs, directly inducing the invasion potential and chemoresistance of ovarian cancer cells by triggering their pro-survival signaling pathways...
May 22, 2020: Cells
https://read.qxmd.com/read/32418122/current-insights-into-the-metastasis-of-epithelial-ovarian-cancer-hopes-and-hurdles
#16
REVIEW
Meysam Yousefi, Sadegh Dehghani, Rahim Nosrati, Mahmoud Ghanei, Arash Salmaninejad, Sara Rajaie, Malihe Hasanzadeh, Alireza Pasdar
BACKGROUND: Ovarian cancer is the most lethal gynecologic cancer and the fifth leading cause of cancer-related mortality in women worldwide. Despite various attempts to improve the diagnosis and therapy of ovarian cancer patients, the survival rate for these patients is still dismal, mainly because most of them are diagnosed at a late stage. Up to 90% of ovarian cancers arise from neoplastic transformation of ovarian surface epithelial cells, and are usually referred to as epithelial ovarian cancer (EOC)...
May 16, 2020: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/32103261/the-omentum-a-niche-for-premetastatic-ovarian-cancer
#17
COMMENT
Xiaojing Ma
The work by Etzerodt et al. in this issue of JEM (https://doi.org/10.1084/jem.20191869) identifies a distinct omentum-resident macrophage population of embryonic origin and demonstrates that these cells provide a niche for ovarian cancer metastasis and cancer stemness. This research opens up for many questions and therapeutic prospects.
April 6, 2020: Journal of Experimental Medicine
https://read.qxmd.com/read/31951251/tissue-resident-macrophages-in-omentum-promote-metastatic-spread-of-ovarian-cancer
#18
JOURNAL ARTICLE
Anders Etzerodt, Morgane Moulin, Thomas Koed Doktor, Marcello Delfini, Noushine Mossadegh-Keller, Marc Bajenoff, Michael H Sieweke, Søren Kragh Moestrup, Nathalie Auphan-Anezin, Toby Lawrence
Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs) play important roles in cancer progression. Here, we have characterized the ontogeny and function of TAM subsets in a mouse model of metastatic ovarian cancer that is representative for visceral peritoneal metastasis. We show that the omentum is a critical premetastatic niche for development of invasive disease in this model and define a unique subset of CD163+ Tim4+ resident omental macrophages responsible for metastatic spread of ovarian cancer cells...
April 6, 2020: Journal of Experimental Medicine
https://read.qxmd.com/read/31695427/tumor-associated-macrophages-tams-a-critical-activator-in-ovarian-cancer-metastasis
#19
REVIEW
Meichen Yin, Jiayu Shen, Shuqian Yu, Jing Fei, Xiaoqing Zhu, Jiayao Zhao, Lingyun Zhai, Annapurna Sadhukhan, Jianwei Zhou
Tumor-associated macrophages (TAMs) that appear in every stage of cancer progression are usually tumor-promoting cells and are present abundantly in the tumor-associated microenvironment. In ovarian cancer, the overall and intratumoral M1/M2 ratio is a relatively efficient TAM parameter for predicting the prognosis of patients, especially for serous tissue type cancer. TAMs exhibit immunological checkpoint modulators, such as the B7 family and programmed death-ligand 1 (PD-L1), and play a key role in the development, metastasis and invasion of ovarian cancer, but the underlying mechanism is barely understood...
2019: OncoTargets and Therapy
https://read.qxmd.com/read/28275576/the-unique-molecular-and-cellular-microenvironment-of-ovarian-cancer
#20
REVIEW
Thomas Worzfeld, Elke Pogge von Strandmann, Magdalena Huber, Till Adhikary, Uwe Wagner, Silke Reinartz, Rolf Müller
The reciprocal interplay of cancer cells and host cells is an indispensable prerequisite for tumor growth and progression. Cells of both the innate and adaptive immune system, in particular tumor-associated macrophages (TAMs) and T cells, as well as cancer-associated fibroblasts enter into a malicious liaison with tumor cells to create a tumor-promoting and immunosuppressive tumor microenvironment (TME). Ovarian cancer, the most lethal of all gynecological malignancies, is characterized by a unique TME that enables specific and efficient metastatic routes, impairs immune surveillance, and mediates therapy resistance...
2017: Frontiers in Oncology
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