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Macrophage, omentum, ovarian cancer

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https://www.readbyqxmd.com/read/26555178/in-vivo-and-ex-vivo-approaches-to-study-ovarian-cancer-metastatic-colonization-of-milky-spot-structures-in-peritoneal-adipose
#1
Venkatesh Krishnan, Robert Clark, Marina Chekmareva, Amy Johnson, Sophia George, Patricia Shaw, Victoria Seewaldt, Carrie Rinker-Schaeffer
High-grade serous ovarian cancer (HGSC), the cause of widespread peritoneal metastases, continues to have an extremely poor prognosis; fewer than 30% of women are alive 5 years after diagnosis. The omentum is a preferred site of HGSC metastasis formation. Despite the clinical importance of this microenvironment, the contribution of omental adipose tissue to ovarian cancer progression remains understudied. Omental adipose is unusual in that it contains structures known as milky spots, which are comprised of B, T, and NK cells, macrophages, and progenitor cells surrounding dense nests of vasculature...
October 14, 2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/25168677/metabolic-orchestration-between-cancer-cells-and-tumor-microenvironment-as-a-co-evolutionary-source-of-chemoresistance-in-ovarian-cancer-a-therapeutic-implication
#2
REVIEW
Dong Hoon Suh, Hee Seung Kim, Boyun Kim, Yong Sang Song
Our group reported a significant association between hexokinase II overexpression and chemoresistance in ovarian cancer, suggesting that aerobic glycolysis in the so-called Warburg effect might contribute to cancer progression. However, a growing body of evidence indicates contradictory findings with regard to the Warburg effect, such as high mitochondrial activity in highly invasive tumors and low ATP contribution of glycolysis in ovarian cancer. As a solution for the dilemma of the Warburg effect, the "reverse Warburg effect" was proposed in which aerobic glycolysis might occur in the stromal compartment of the tumor rather than in the cancer cells, indicating that the glycolytic tumor stroma feed the cancer cells through a type of symbiotic relationship...
November 1, 2014: Biochemical Pharmacology
https://www.readbyqxmd.com/read/24022590/the-parity-associated-microenvironmental-niche-in-the-omental-fat-band-is-refractory-to-ovarian-cancer-metastasis
#3
Courtney A Cohen, Amanda A Shea, C Lynn Heffron, Eva M Schmelz, Paul C Roberts
Ovarian cancer is an insidious and aggressive disease of older women, typically undiscovered before peritoneal metastasis due to its asymptomatic nature and lack of early detection tools. Epidemiologic studies suggest that child-bearing (parity) is associated with decreased ovarian cancer risk, although the molecular mechanisms responsible for this phenomenon have not been delineated. Ovarian cancer preferentially metastasizes to the omental fat band (OFB), a secondary lymphoid organ that aids in filtration of the peritoneal serous fluid (PSF) and helps combat peritoneal infections...
November 2013: Cancer Prevention Research
https://www.readbyqxmd.com/read/22322968/the-peritoneal-tumour-microenvironment-of-high-grade-serous-ovarian-cancer
#4
D Andrew Leinster, Hagen Kulbe, Gemma Everitt, Richard Thompson, Mauro Perretti, Felicity N E Gavins, Dianne Cooper, David Gould, Darren P Ennis, Michelle Lockley, Iain A McNeish, Sussan Nourshargh, Frances R Balkwill
High-grade serous ovarian cancer (HGSC) disseminates early and extensively throughout the peritoneal space, causing multiple lesions that are a major clinical problem. The aim of this study was to investigate the cellular composition of peritoneal tumour deposits in patient biopsies and their evolution in mouse models using immunohistochemistry, intravital microscopy, confocal microscopy, and 3D modelling. Tumour deposits from the omentum of HGSC patients contained a prominent leukocyte infiltrate of CD3(+) T cells and CD68(+) macrophages, with occasional neutrophils...
June 2012: Journal of Pathology
https://www.readbyqxmd.com/read/17330402/development-of-a-novel-oligomannose-coated-liposome-based-anticancer-drug-delivery-system-for-intraperitoneal-cancer
#5
REVIEW
Yuzuru Ikehara, Naoya Kojima
Almost all patients with gastrointestinal or ovarian malignancy die as a result of progression and/or recurrence in the peritoneal cavity. Although palliative systemic chemotherapy may succeed in improving the survival of patients with a particular type of cancer, almost all patients with ovarian and gastric cancers die from involvement of the abdominal cavity. In order to successfully treat such cases, new therapeutic technologies must be based upon an understanding of the mechanisms involved in intraperitoneal metastasis...
February 2007: Current Opinion in Molecular Therapeutics
https://www.readbyqxmd.com/read/16311732/insufficient-ability-of-omental-milky-spots-to-prevent-peritoneal-tumor-outgrowth-supports-omentectomy-in-minimal-residual-disease
#6
S J Oosterling, G J van der Bij, M Bögels, J R M van der Sijp, R H J Beelen, S Meijer, M van Egmond
BACKGROUND: The greater omentum is frequently involved in the course of gastrointestinal and ovarian tumors. Therefore, common practice in surgical treatment for especially gastric and ovarian cancer includes removal of the greater omentum. Paradoxically, many immune cells, such as macrophages that accumulate in so-called milky spots, reside within the omentum and are cytotoxic against tumor cells ex vivo. Consequently, omental macrophages might play an important role in killing tumor cells, and may hereby prevent development into local peritoneal recurrences...
September 2006: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/11753986/ovarian-epithelial-carcinoma-tyrosine-phosphorylation-cell-proliferation-and-ezrin-translocation-are-stimulated-by-interleukin-1alpha-and-epidermal-growth-factor
#7
Z Chen, A Fadiel, Y Feng, K Ohtani, T Rutherford, F Naftolin
BACKGROUND: Ezrin is a member of the ezrin, radixin, and moesin family. These proteins are membrane-actin cross-linking proteins. Furthermore, ezrin is an important signal transduction protein that undergoes phosphorylation and translocation on stimulation by growth factors. Ezrin phosphorylation and translocation are thought to be correlated with cell motility, invasion, and carcinoma metastasis. Recently, the authors reported that an ezrin antisense phosphorothionate could significantly inhibit endometrial carcinoma cells' penetration in the Matrigel membrane cancer invasion assay...
December 15, 2001: Cancer
https://www.readbyqxmd.com/read/2583871/paradoxical-effects-of-tumour-necrosis-factor-in-experimental-ovarian-cancer
#8
S T Malik, D B Griffin, W Fiers, F R Balkwill
Recombinant human tumour necrosis factor (rhTNF) had anti-tumour activity against 2 of 3 human ovarian cancer xenografts growing intraperitoneally (i.p.) in nude mice, producing a moderate (2- to 3-fold) increase in mouse survival time. rhTNF therapy caused a marked influx of polymorphonuclear neutrophils into the peritoneal cavity during the first few days of daily therapy. This was accompanied by a decrease in the number of peritoneal macrophages and lymphocytes. rhTNF also caused an increase in peripheral blood neutrophils...
November 15, 1989: International Journal of Cancer. Journal International du Cancer
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