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https://www.readbyqxmd.com/read/29146015/tablet-based-sublingual-immunotherapy-for-respiratory-allergy
#1
REVIEW
L Prieto
Allergic respiratory disease represents a significant and expanding health problem worldwide. The gold standard of therapeutic intervention is still grucocorticosteroids, although they are not effective in all patients and may cause side effects. Allergen Immunotherapy has been administrated as subcutaneous injections for treatment of allergic rhinoconjunctivitis and asthma and has been practiced for the past century. Sublingual immunotherapy (SLIT) tablets are now available for grass- or ragweed-induced rhinoconjunctivitis and will be available in Spain for house dust mite (HDM)-induced rhinoconjunctivitis and asthma in the next months...
November 13, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29130801/the-relevance-of-house-dust-mites-allergy-in-clinical-practice-the-epidemiological-impact-on-allergen-immunotherapy
#2
Giorgio Ciprandi, Paola Puccinelli, Cristoforo Incorvaia, Giovanni Passalacqua
House dust mite (HDM) is the most common cause of respiratory allergy worldwide. The impact of HDM allergy is influenced by a number of factors, including local climate. We investigated such issue in Italy, using a real-life setting, including outpatients visited at allergy clinics. In 9143 patients (7873 adults and 1270 children) who were evaluated in 15 allergy clinics, investigating as well the rate of prescription of allergen immunotherapy. The present study confirms that Mediterranean climate is associated with a higher prevalence of mite allergy than continental climate...
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29130795/comparison-of-two-different-assays-and-the-predictive-value-of-allergen-components-in-house-dust-mite-allergy
#3
Johannes Schulze, Lisanne Leberkuehne, Emilia Salzmann-Manrique, Ralf Schubert, Stefan Zielen, Martin Rosewich
AIM: In house dust mite (HDM) allergy diagnostics, the IMMULITE, ImmunoCAP and assays for allergen components (nDer p 1 and rDer p 2) are available. METHODS: Serum sIgE levels were compared and the predictive values for the detection of an early asthmatic response (EAR) were calculated with receiver operating characteristics and a log-logistic regression model. RESULTS: sIgE levels of IMMULITE and ImmunoCAP were similar (Dermatophagoides pteronyssinus [D...
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29081610/analysis-of-predicted-b-and-t-cell-epitopes-in-der-p-23-allergen-from-dermatophagoides-pteronyssinus
#4
Songwe Fanuel, Saeideh Tabesh, Esmaeil Sadroddiny, Gholam Ali Kardar
House dust mite (HDM) allergy is the leading cause of IgE-mediated hypersensitivity. Therefore identifying potential epitopes in the Dermatophagoide pteronyssinus 23 (Der p 23), a major house dust mite allergen will aid in the development of therapeutic vaccines and diagnostic kits for HDM allergy. Experimental methods of epitope discovery have been widely exploited for the mapping of potential allergens. This study sought to use immunoinformatic methods to analyze the structure of Der p 23 for potential immunoreactive B and T-cell epitopes that could be useful for AIT and allergy diagnosis...
2017: Bioinformation
https://www.readbyqxmd.com/read/29079219/house-dust-mite-allergy-its-innate-immune-response-and-immunotherapy
#5
REVIEW
Fang-Liang Huang, En-Chih Liao, Sheng-Jie Yu
Over the past few decades, allergic diseases have become increasingly prevalent worldwide. House dust mite (HDM) is the most important domestic source for allergic diseases such as allergic rhinitis, asthma and atopic dermatitis. Dermatophagoides pteronyssinus (Der p) is the major environmental allergen in southeast Asia because of the humid and warm environment is suitable for its growth. In the recent year, role of HDM allergen in allergic inflammation through innate immune system has been well studied. Toll-like receptors (TLRs), protease-activated receptors (PARs) and DC-SIGN could be activated by different HDM major allergens and proinflammatory cytokines also be upregulated...
October 16, 2017: Immunobiology
https://www.readbyqxmd.com/read/29072879/cockroach-is-a-major-cross-reactive-allergen-source-in-shrimp-sensitized-rural-children-in-southern-china
#6
Zhaowei Yang, Jiefeng Zhao, Nili Wei, Mulin Feng, Mo Xian, Xu Shi, Zhenyu Zheng, Qiujuan Su, Gary W K Wong, Jing Li
BACKGROUND: Little is known about the prevalence of food allergy (FA) in China. OBJECTIVE: To investigate the prevalence of FA and its disparity between urban and rural areas in southern China. METHODS: Europrevall questionnaire responses were obtained from 5,542 school-age-children in urban Guangzhou and 5,319 in rural Shaoguan. A case-control study enrolled 190 children with adverse reactions (ARs) after food intake as cases, and 212 controls in Guangzhou; 116 cases and 233 controls in Shaoguan...
October 26, 2017: Allergy
https://www.readbyqxmd.com/read/29047167/the-association-between-an-genetic-risk-score-for-allergy-and-the-risk-of-developing-allergies-in-childhood-results-of-the-whistler-cohort
#7
Ali Arabkhazaeli, Fariba Ahmadizar, Maarten Leusink, Hubertus G M Arets, Jan A M Raaijmakers, Cuno S Uiterwaal, Cornelis K van der Ent, Anke-Hilse Maitland-van der Zee, Susanne J H Vijverberg
BACKGROUND: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children. METHODS: A GRS was constructed based on 10 SNPs previously associated with allergies in adults...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29045689/sensitivity-to-house-dust-mites-allergens-with-atopic-asthma-and-its-relationship-with-cd14-c-159t-polymorphism-in-patients-of-west-bengal-india
#8
Amlan Ghosh, Shampa Dutta, Sanjoy Podder, Priti Mondal, Arghya Laha, Nimai Chandra Saha, Saibal Moitra, Goutam Kumar Saha
India is the home to around 15-20 million asthmatics, and asthma prevalence is increasing in Indian metropolitan area, including Kolkata, West Bengal. Complex interactions of genetic and environmental factors are involved in asthma. Genome-wide search for susceptible loci regulating IgE response (atopy) have identified a candidate gene CD14 which is most important in the context of allergic responses of respiratory system. This study was aimed to investigate the role of house dust and house dust mites in development of bronchial asthma and to explore the possible association of candidate gene CD14 with disease manifestation among Kolkata patient population...
October 17, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29038898/molecular-and-immunological-characterisation-of-tropomyosin-from-anisakis-pegreffii
#9
Abdouslam Asnoussi, Ibukun E Aibinu, Robin B Gasser, Andreas L Lopata, Peter M Smooker
Tropomyosin (TM) is a major allergen in shellfish, known to cross-react with mite, cockroach and/or some roundworm (nematode) TM. In this study, we aimed to express and purify TM from the parasitic nematode Anisakis pegreffii and also to characterise its cross-reactivity with TM from shellfish. A. pegreffii was isolated from the flathead tiger fish (Neoplatycephalus richardsoni) and characterised using single-strand conformation polymorphism (SSCP)-based sequencing of the first and second internal transcribed spacers (ITS-1 and ITS-2) of nuclear ribosomal DNA...
October 16, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29022537/respiratory-comorbidity-in-south-african-children-with-atopic-dermatitis
#10
C L Gray, M E Levin, G Du Toit
BACKGROUND: Atopic dermatitis (AD) is an early and important step in the propagation of the allergic march, enhancing food and respiratory allergies via epicutaneous sensitisation to allergens. OBJECTIVES: To determine the prevalence and patterns of aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children with AD. METHODS: This was a prospective, observational study in a paediatric university hospital in Cape Town, SA...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28982170/a-combined-transcriptome-and-proteome-analysis-extends-the-allergome-of-house-dust-mite-dermatophagoides-species
#11
Véronique Bordas-Le Floch, Maxime Le Mignon, Laetitia Bussières, Karine Jain, Armelle Martelet, Véronique Baron-Bodo, Emmanuel Nony, Laurent Mascarell, Philippe Moingeon
BACKGROUND: House dust mites (HDMs) such as Dermatophagoides farinae and D. pteronyssinus represent major causes of perennial allergy. HDM proteomes are currently poorly characterized, with information mostly restricted to allergens. As of today, 33 distinct allergen groups have been identified for these 2 mite species, with groups 1 and 2 established as major allergens. Given the multiplicity of IgE-reactive mite proteins, potential additional allergens have likely been overlooked. OBJECTIVE: To perform a comprehensive characterization of the transcriptomes, proteomes and allergomes of D...
2017: PloS One
https://www.readbyqxmd.com/read/28978515/late-gestation-maternal-dietary-methyl-donor-and-cofactor-supplementation-in-sheep-partially-reverses-protection-against-allergic-sensitization-by-iugr
#12
Amy L Wooldridge, Robert J Bischof, Hong Liu, Gary K Heinemann, Damien S Hunter, Lynne C Giles, Rebecca A Simmons, Yu-Chin Lien, Wenyun Lu, Joshua D Rabinowitz, Karen L Kind, Julie A Owens, Vicki L Clifton, Kathryn L Gatford
Perinatal exposures are associated with altered risks of childhood allergy. Human studies and our previous work suggest restricted growth in utero (IUGR) is protective against allergic disease. The mechanisms are not clearly defined but reduced fetal abundance and altered metabolism of methyl donors are hypothesized as possible underlying mechanisms. We therefore examined whether late gestation maternal dietary methyl donor and co-factor supplementation of the placentally-restricted (PR) sheep pregnancy would reverse allergic protection in progeny...
October 4, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28950285/could-sublingual-immunotherapy-affect-oral-health-in-children-with-asthma-and-or-allergic-rhinitis-sensitized-to-house-dust-mite
#13
Ayca Kiykim, Gonca Mumcu, Ismail Ogulur, Elif Karakoc-Aydiner, Haner Direskeneli, Safa Baris, Hasret Cagan, Ahmet Ozen
BACKGROUND: Sublingual immunotherapy (SLIT) has been successfully employed in IgE-mediated respiratory allergies. However, it is not known whether the modulation of immune responses in the sublingual area during SLIT has any deleterious effect on oral health. We sought to determine the oral health prospectively in children receiving SLIT for house dust mite allergy. MATERIAL AND METHODS: Eighteen children with allergic asthma and/or rhinitis and 31 age-matched healthy controls (HC) were included in an open-labeled trial...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28950271/bioavailability-of-house-dust-mite-allergens-in-sublingual-allergy-tablets-is-highly-dependent-on-the-formulation
#14
Katsuyo Ohashi-Doi, Hirokazu Kito, Weibin Du, Hiroshi Nakazawa, Henrik Ipsen, Pernille Gudmann, Kaare Lund
BACKGROUND: In sublingual immunotherapy (SLIT), the immune system is addressed by solubilized allergen that interacts with immunocompetent cells of the oral mucosa, the efficiency of which is governed by 2 main factors of SLIT allergen bioavailability: the allergen concentration and the mucosal contact time. Recently, 3 house dust mite (HDM) SLIT tablets were developed that differ with regard to allergen content, nominal strength (maintenance doses: 6 SQ-HDM/10,000 Japanese Allergen Units [JAU], 12 SQ-HDM/ 20,000 JAU, and 300 IR/57,000 JAU), and formulation (freeze-dried/compressed)...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28950268/the-sq-house-dust-mite-slit-tablet-is-well-tolerated-in-patients-with-house-dust-mite-respiratory-allergic-disease
#15
RANDOMIZED CONTROLLED TRIAL
Waltraud Emminger, María Dolores Hernández, Victòria Cardona, Frank Smeenk, Bodil S Fogh, Moises A Calderon, Frederic de Blay, Vibeke Backer
BACKGROUND: The SQ house dust mite (HDM) SLIT-tablet (ALK, Denmark) addresses the underlying cause of HDM respiratory allergic disease, and a clinical effect has been demonstrated for both HDM allergic rhinitis and allergic asthma. Here, we present pooled safety data from an adult population with HDM respiratory allergy, with particular focus on the impact of asthma on the SQ HDM SLIT-tablet tolerability profile. METHODS: Safety data from 2 randomised double-blind, placebo-controlled clinical trials were included: MT-04: 834 adults with HDM allergic asthma not well controlled by inhaled corticosteroids and with HDM allergic rhinitis, and MT-06: 992 adults with moderate-to-severe HDM allergic rhinitis despite the use of allergy pharmacotherapy and with or without asthma...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28932387/peak-nasal-inspiratory-flow-as-outcome-for-provocation-studies-in-allergen-exposure-chambers-a-ga-2-len-study
#16
Georg Boelke, Uwe Berger, Karl-Christian Bergmann, Carsten Bindslev-Jensen, Jean Bousquet, Julia Gildemeister, Marek Jutel, Oliver Pfaar, Torsten Sehlinger, Torsten Zuberbier
BACKGROUND: The GA(2)LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28926718/corrigendum
#17
(no author information available yet)
Brunner JP, Jawad BA, McCoul ED. Polypoid change of the middle turbinate and paranasal sinus polyposis are distinct entities. Otolaryngol Head Neck Surg. 2017;157:519-523. (Original doi: 10.1177/0194599817711887) The Results section of this article and its abstract contained several errors in describing data that appears in Tables 1 and 2. The tables contain the correct information, the corrected abstract and article text appears below. Abstract: Results. Of 593 patients, 23 (3.9%) had PCMT and 44 (7.4%) had PSP...
September 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28904968/the-prevalence-of-ocular-allergy-and-comorbidities-in-chinese-school-children-in-shanghai
#18
Yanqing Feng, Xiangning Wang, Fang Wang, Rongming Liu, Lu Chen, Shuqin Wu, Xia Yang, Miaoying Chen, Yu-Qing Rao, Jing Li
OBJECTIVE: To investigate the prevalence and features of ocular allergy (OA) and comorbidities among school children in Shanghai, China. METHODS: This was a population-based cross-sectional study. Each participant completed an ISAAC-based questionnaire. The prevalence of OA symptoms, allergic rhinitis (AR) asthma, atopic dermatitis (AD), and sensitization to mites, pollen, and food was analyzed. RESULTS: A total of 724 and 942 completed questionnaires from the 7-9-year-old (young group) and the 12-14-year-old (teen group) groups were analyzed, respectively...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28902467/eaaci-guidelines-on-allergen-immunotherapy-prevention-of-allergy
#19
REVIEW
Susanne Halken, Desiree Larenas-Linnemann, Graham Roberts, Moises A Calderón, Elisabeth Angier, Oliver Pfaar, Dermot Ryan, Ioana Agache, Ignacio J Ansotegui, Stefania Arasi, George Du Toit, Montserrat Fernandez-Rivas, Roy Geerth van Wijk, Marek Jutel, Jörg Kleine-Tebbe, Susanne Lau, Paolo M Matricardi, Giovanni B Pajno, Nikolaos G Papadopoulos, Martin Penagos, Alexandra F Santos, Gunter J Sturm, Frans Timmermans, R van Ree, Eva-Maria Varga, Ulrich Wahn, Maria Kristiansen, Sangeeta Dhami, Aziz Sheikh, Antonella Muraro
Allergic diseases are common and frequently coexist. Allergen immunotherapy (AIT) is a disease-modifying treatment for IgE-mediated allergic disease with effects beyond cessation of AIT that may include important preventive effects. The European Academy of Allergy and Clinical Immunology (EAACI) has developed a clinical practice guideline to provide evidence-based recommendations for AIT for the prevention of (i) development of allergic comorbidities in those with established allergic diseases, (ii) development of first allergic condition, and (iii) allergic sensitization...
September 13, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28892575/effects-of-treating-helminths-during-pregnancy-and-early-childhood-on-risk-of-allergy-related-outcomes-follow-up-of-a-randomized-controlled-trial
#20
Benigna Namara, Stephen Nash, Swaib A Lule, Hellen Akurut, Harriet Mpairwe, Florence Akello, Josephine Tumusiime, Moses Kizza, Joyce Kabagenyi, Gyaviira Nkurunungi, Lawrence Muhangi, Emily L Webb, Moses Muwanga, Alison M Elliott
BACKGROUND: Helminth infections, common in low-income countries, may protect against allergy-related disease. Early exposure may be a key. In the Entebbe Mother and Baby Study, treating helminths during pregnancy resulted in increased eczema rates in early childhood. We followed the cohort to determine whether this translated to increased asthma rates at school age. METHODS: This randomized, double-blind, placebo-controlled trial, conducted in Entebbe, Uganda, had three interventions...
September 11, 2017: Pediatric Allergy and Immunology
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