keyword
https://read.qxmd.com/read/38117586/racial-and-ethnic-disparities-in-phthalate-exposure-and-preterm-birth-a-pooled-study-of-sixteen-u-s-cohorts
#21
JOURNAL ARTICLE
Barrett M Welch, Alexander P Keil, Jessie P Buckley, Stephanie M Engel, Tamarra James-Todd, Ami R Zota, Akram N Alshawabkeh, Emily S Barrett, Michael S Bloom, Nicole R Bush, José F Cordero, Dana Dabelea, Brenda Eskenazi, Bruce P Lanphear, Vasantha Padmanabhan, Sheela Sathyanarayana, Shanna H Swan, Jenny Aalborg, Donna D Baird, Alexandra M Binder, Asa Bradman, Joseph M Braun, Antonia M Calafat, David E Cantonwine, Kate E Christenbury, Pam Factor-Litvak, Kim G Harley, Russ Hauser, Julie B Herbstman, Irva Hertz-Picciotto, Nina Holland, Anne Marie Z Jukic, Thomas F McElrath, John D Meeker, Carmen Messerlian, Karin B Michels, Roger B Newman, Ruby H N Nguyen, Katie M O'Brien, Virginia A Rauh, Bruce Redmon, David Q Rich, Emma M Rosen, Rebecca J Schmidt, Amy E Sparks, Anne P Starling, Christina Wang, Deborah J Watkins, Clarice R Weinberg, Barry Weinberger, Abby G Wenzel, Allen J Wilcox, Kimberly Yolton, Yu Zhang, Kelly K Ferguson
BACKGROUND: Phthalate exposures are ubiquitous during pregnancy and may contribute to racial and ethnic disparities in preterm birth. OBJECTIVES: We investigated race and ethnicity in the relationship between biomarkers of phthalate exposure and preterm birth by examining: a ) how hypothetical reductions in racial and ethnic disparities in phthalate metabolites might reduce the probability of preterm birth; and b ) exposure-response models stratified by race and ethnicity...
December 2023: Environmental Health Perspectives
https://read.qxmd.com/read/38116446/discovery-of-5-azaquinoxaline-derivatives-as-potent-and-orally-bioavailable-allosteric-shp2-inhibitors
#22
JOURNAL ARTICLE
Mohamed S A Elsayed, James F Blake, Mark L Boys, Eric Brown, Bruno D Chapsal, Mark J Chicarelli, Adam W Cook, Jay B Fell, John P Fischer, Lauren Hanson, Christine Lemieux, Matthew C Martinson, Joseph McCown, Oren T McNulty, Macedonio J Mejia, Nickolas A Neitzel, Jennifer N Otten, Martha E Rodriguez, Daniel Wilcox, Christina E Wong, Yeyun Zhou, Ronald J Hinklin
SHP2 has emerged as an important target for oncology small-molecule drug discovery. As a nonreceptor tyrosine phosphatase within the MAPK pathway, it has been shown to control cell growth, differentiation, and oncogenic transformation. We used structure-based design to find a novel class of potent and orally bioavailable SHP2 inhibitors. Our efforts led to the discovery of the 5-azaquinoxaline as a new core for developing this class of compounds. Optimization of the potency and properties of this scaffold generated compound 30 , that exhibited potent in vitro SHP2 inhibition and showed excellent in vivo efficacy and pharmacokinetic profile...
December 14, 2023: ACS Medicinal Chemistry Letters
https://read.qxmd.com/read/38078648/the-impact-of-different-thematic-apperception-test-administration-methods-on-narrative-length-and-story-richness-as-measured-by-the-social-cognition-and-object-relations-scale-global-rating-method-scors-g
#23
JOURNAL ARTICLE
Savanna G Coleman, Havilah P Ravula, Michelle B Stein, Jeremy J Coleman, Melanie M Wilcox, Jenelle M Slavin-Mulford
The Thematic Apperception Test (TAT) is the second most commonly used performance-based task in clinical practice. However, traditional TAT administration is time-consuming and raises accessibility issues. This study examines the effect of administration modifications (i.e., examiner handwriting versus typing, examiner recording versus participant recording, and re-prompting versus no re-prompting) on narrative length and richness as measured by the Social Cognition and Object Relations Scale-Global Rating Method (SCORS-G)...
December 11, 2023: Journal of Personality Assessment
https://read.qxmd.com/read/38073038/empagliflozin-in-heart-failure-regional-nephron-sodium-handling-effects
#24
RANDOMIZED CONTROLLED TRIAL
Veena S Rao, Juan B Ivey-Miranda, Zachary L Cox, Julieta Moreno-Villagomez, Christopher Maulion, Lavanya Bellumkonda, John Chang, M Paul Field, Daniel R Wiederin, Javed Butler, Sean P Collins, Jeffrey M Turner, F Perry Wilson, Silvio E Inzucchi, Christopher S Wilcox, David H Ellison, Jeffrey M Testani
SIGNIFICANCE STATEMENT: The effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on regional tubular sodium handling is poorly understood in humans. In this study, empagliflozin substantially decreased lithium reabsorption in the proximal tubule (PT) (a marker of proximal tubular sodium reabsorption), a magnitude out of proportion to that expected with only inhibition of sodium-glucose cotransporter-2. This finding was not driven by an "osmotic diuretic" effect; however, several parameters changed in a manner consistent with inhibition of the sodium-hydrogen exchanger 3...
February 1, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38045281/impact-of-pulse-pressure-on-acute-brain-injury-in-venoarterial-ecmo-patients-with-cardiogenic-shock-during-the-first-24-hours-of-ecmo-cannulation-analysis-of-the-extracorporeal-life-support-organization-registry
#25
Andrew Kalra, Jin Kook Kang, Christopher Wilcox, Patricia Brown, Peter Rycus, Marc M Anders, Akram M Zaaqoq, Daniel Brodie, Glenn J R Whitman, Sung-Min Cho
Background : Low pulse pressure (PP) in venoarterial-extracorporeal membrane oxygenation (VA-ECMO) is a marker of cardiac dysfunction and has been associated with acute brain injury (ABI) as continuous-flow centrifugal pump may lead to endothelial dysregulation. Methods : We retrospectively analyzed adults (≥18 years) on "peripheral" VA-ECMO support for cardiogenic shock in the Extracorporeal Life Support Organization Registry (1/2018-7/2023). Cubic splines were used to establish a threshold (PP≤10 mmHg at 24 hours of ECMO support) for "early low" PP...
November 23, 2023: Research Square
https://read.qxmd.com/read/38043796/clostridioides-difficile-canonical-l-d-transpeptidases-catalyse-a-novel-type-of-peptidoglycan-cross-links-and-are-not-required-for-beta-lactam-resistance
#26
JOURNAL ARTICLE
Nicola F Galley, Darren Greetham, Marcel G Alamán-Zárate, Mike P Williamson, Caroline A Evans, William D Spittal, Jessica E Buddle, Jane Freeman, Georgina L Davis, Mark J Dickman, Mark H Wilcox, Andrew L Lovering, Robert P Fagan, Stéphane Mesnage
Clostridioides difficile is the leading cause of antibiotic-associated diarrhoea worldwide with significant morbidity and mortality. This organism is naturally resistant to several beta-lactam antibiotics that inhibit the polymerisation of peptidoglycan, an essential component of the bacteria cell envelope. Previous work has revealed that C. difficile peptidoglycan has an unusual composition. It mostly contains 3-3 cross-links, catalysed by enzymes called L,D-transpeptidases (Ldts) that are poorly inhibited by beta-lactams...
December 1, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/38031573/return-to-work-following-brachial-plexus-injury-a-cross-sectional-study
#27
JOURNAL ARTICLE
Hazel Brown, Kate Kennard, Rosalyn Tyreman, Ali Alim-Marvasti, Matthew Wilcox, Tom Quick
BACKGROUND: Qualitative studies following Brachial Plexus Injury (BPI) suggest that return to employment has a major influence on life satisfaction and psychological well-being. However, few studies have focused on return to work following BPI. The physical strain and intensity of an occupation may influence the ability of an individual to return to employment. This study aimed to provide information about the impact of workload intensity on employment status following BPI. METHODS: This is an observational, retrospective study of 74 participants who responded to a postal questionnaire, sharing information regarding their employment status pre- and post-BPI...
December 2023: Hand Therapy
https://read.qxmd.com/read/38014220/characterizing-the-racial-discrepancy-in-hypoxemia-detection-in-vv-ecmo-an-elso-registry-analysis
#28
Andrew Kalra, Christopher Wilcox, Sari D Holmes, Joseph E Tonna, In Seok Jeong, Peter Rycus, Marc M Anders, Akram M Zaaqoq, Roberto Lorusso, Daniel Brodie, Steven P Keller, Bo Soo Kim, Glenn J R Whitman, Sung-Min Cho
Importance : Skin pigmentation influences peripheral oxygen saturation (SpO 2 ) measured by pulse oximetry compared to the arterial saturation of oxygen (SaO 2 ) measured via arterial blood gas analysis. However, data on SpO 2 -SaO 2 discrepancy are limited in venovenous-extracorporeal membrane oxygenation (VV-ECMO) patients. Objective : To determine whether there is racial/ethnical discrepancy between SpO 2 and SaO 2 in patients receiving VV-ECMO. We hypothesized VV-ECMO cannulation, in addition to race/ethnicity, accentuates the SpO 2 -SaO 2 discrepancy due to significant hemolysis...
November 17, 2023: Research Square
https://read.qxmd.com/read/37981695/impact-of-arid1a-and-tp53-mutations-in-pediatric-refractory-or-relapsed-mature-b-cell-lymphoma-treated-with-car-t-cell-therapy
#29
JOURNAL ARTICLE
Yang Li, Yang Liu, Keyan Yang, Ling Jin, Jing Yang, Shuang Huang, Ying Liu, Bo Hu, Rong Liu, Wei Liu, Ansheng Liu, Qinlong Zheng, Yonghong Zhang
BACKGROUND: Chimeric antigen receptor (CAR)-T cell therapy has been used to treat pediatric refractory or relapsed mature B-cell non-Hodgkin lymphoma (r/r MB-NHL) with significantly improved outcomes, but a proportion of patients display no response or experience relapse after treatment. To investigate whether tumor-intrinsic somatic genetic alterations have an impact on CAR-T cell treatment, the genetic features and treatment outcomes of 89 children with MB-NHL were analyzed. METHODS: 89 pediatric patients treated at multiple clinical centers of the China Net Childhood Lymphoma (CNCL) were included in this study...
November 19, 2023: Cancer Cell International
https://read.qxmd.com/read/37980922/upfront-endoscopic-necrosectomy-or-step-up-endoscopic-approach-for-infected-necrotising-pancreatitis-destin-a-single-blinded-multicentre-randomised-trial
#30
RANDOMIZED CONTROLLED TRIAL
Ji Young Bang, Sundeep Lakhtakia, Shyam Thakkar, James L Buxbaum, Irving Waxman, Bryce Sutton, Sana F Memon, Shailendra Singh, Jahangeer Basha, Ajay Singh, Udayakumar Navaneethan, Robert H Hawes, Charles M Wilcox, Shyam Varadarajulu
BACKGROUND: Although the preferred management approach for patients with infected necrotising pancreatitis is endoscopic transluminal stenting followed by endoscopic necrosectomy as step-up treatment if there is no clinical improvement, the optimal timing of necrosectomy is unclear. Therefore, we aimed to compare outcomes between performing upfront necrosectomy at the index intervention versus as a step-up measure in patients with infected necrotising pancreatitis. METHODS: This single-blinded, multicentre, randomised trial (DESTIN) was done at six tertiary care hospitals (five hospitals in the USA and one hospital in India)...
January 2024: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/37946237/epidemiology-of-ischemic-stroke-and-hemorrhagic-stroke-in-venoarterial-extracorporeal-membrane-oxygenation
#31
JOURNAL ARTICLE
Jaeho Hwang, Andrew Kalra, Benjamin L Shou, Glenn Whitman, Christopher Wilcox, Daniel Brodie, Akram M Zaaqoq, Roberto Lorusso, Ken Uchino, Sung-Min Cho
BACKGROUND: While venoarterial extracorporeal membrane oxygenation (V-A ECMO) provides lifesaving support for cardiopulmonary failure, complications may increase mortality, with few studies focusing on ischemic/hemorrhagic stroke. We aimed to determine the trends and associations of stroke incidence and mortality, and their risk factors, including the effects of annual case volumes of ECMO centers. METHODS: Retrospective analysis was performed on the Extracorporeal Life Support Organization (ELSO) registry, including adult V-A ECMO patients from 534 international centers between 2012 and 2021, excluding extracorporeal cardiopulmonary resuscitation...
November 9, 2023: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/37940718/investigating-the-correlation-between-small-molecular-inhibitor-utilization-peripheral-blood-monocytes-and-treatment-outcomes-in-rosai-dorfman-disease
#32
JOURNAL ARTICLE
Samuel B Reynolds, Sabrina Wilcox, Qing Li, Asra Z Ahmed
Rosai Dorfman disease (RDD) is a non-Langerhans cell histiocytic neoplasm characterized by sinus histiocytosis with variable emperipolesis. There is a limited understanding of the factors that contribute to disease progression. Traditional management of RDD consists of local therapies (resection, radiation) for localized disease and myelosuppression for systemic disease; targeted medications have also recently been introduced into clinical practice as an additional therapeutic modality. The goals of this study are to compare the impact of targeted therapies to conventional management of RDD and identify trends in laboratory data that may provide insight into disease progression...
November 9, 2023: Annals of Hematology
https://read.qxmd.com/read/37939625/simple-quantitative-planimetric-measurement-of-nigrosome-1-for-clinical-settings
#33
JOURNAL ARTICLE
Minh T Chau, Marc Agzarian, Robert A Wilcox, Andrew Dwyer, Eva Bezak, Gabrielle Todd
INTRODUCTION: Loss of MRI hyperintense signal in nigrosome-1 (assessed with susceptibility-weighted imaging) is a biomarker for Parkinson's disease (PD). Current clinical practice involves subjectively rating the appearance of nigrosome-1 which is challenging. The study aimed to test and compare a simple method for quantifying nigrosome-1 with the current subjective rating method. METHODS: Two experienced neuroradiologists measured area of hyperintense signal in nigrosome-1 (quantitative method) and rated nigrosome-1 appearance (as normal, attenuated, or absent; subjective method) in 42 patients encompassing the full spectrum of nigrosome-1 integrity (21 patients aged 55...
October 29, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37935813/neutrophil-to-lymphocyte-ratio-ntlr-predicts-local-control-and-overall-survival-after-stereotactic-body-radiotherapy-sbrt-in-metastatic-sarcoma
#34
JOURNAL ARTICLE
Eashwar Somasundaram, Peter M Anderson, Timothy D Smile, Ahmed Halima, James B Broughman, Chandana A Reddy, Shireen Parsai, Jacob G Scott, Timothy Chan, Shauna Campbell, Lilyana Angelov, Stacey Zahler, Matteo Trucco, Stefanie M Thomas, Shavaughn Johnson, Peng Qi, Anthony Magnelli, Erin S Murphy
The neutrophil to lymphocyte ratio (NTLR) and absolute lymphocyte count (ALC) recovery are prognostic across many cancers. We investigated whether NLTR predicts SBRT success or survival in a metastatic sarcoma cohort treated with SBRT from 2014 and 2020 (N = 42). Wilcox Signed Rank Test and Friedman Test compare NTLR changes with local failure vs. local control (N = 138 lesions). Cox analyses identified factors associated with overall survival. If local control was successful, NLTR change was not significant (p = 0...
November 7, 2023: Scientific Reports
https://read.qxmd.com/read/37935389/contrasting-water-use-strategies-revealed-by-species-specific-transpiration-dynamics-in-the-caatinga-dry-forest
#35
JOURNAL ARTICLE
Cynthia L Wright, Jason B West, André L A de Lima, Eduardo S Souza, Maria Medeiros, Bradford P Wilcox
In forest ecosystems, transpiration patterns are important for quantifying water and carbon fluxes and are major factors in predicting ecosystem change. Seasonal changes in rainfall and soil water content can alter the sensitivity of sap flux density to daily variations in vapor pressure deficit. This sensitivity is species-specific and is thought to be related to hydraulic strategies. The aim of this work is to better understand how the sap flux density of species with low vs. high wood densities differ in their sensitivity to vapor pressure deficit and soil water content, and how potentially opposing water use strategies influence transpiration dynamics and ultimately correlations to evapotranspiration...
November 3, 2023: Tree Physiology
https://read.qxmd.com/read/37931277/sacral-neuromodulation-in-the-golden-years-treatment-outcomes-in-elderly-75-years-and-older
#36
JOURNAL ARTICLE
Roseanne Ferreira, Samuel Otis-Chapados, Emad Alwashmi, Naeem Bhojani, Kevin C Zorn, Bilal Chughtai, Dean S Elterman
INTRODUCTION: Despite high prevalence and increased severity and burden of overactive bladder (OAB) and fecal incontinence (FI) in the elderly, sacral neuromodulation (SNM) is often overlooked as a potential treatment option for this demographic. In this study, we report the outcomes of SNM in patients aged 75 years or older at the time of surgery. METHODS: We conducted a retrospective cohort study of patients who underwent SNM implantation between 2013 and 2022 performed by a single high-volume urologist at a tertiary center...
October 23, 2023: Canadian Urological Association Journal
https://read.qxmd.com/read/37921666/adverse-pregnancy-outcomes-and-renal-vascular-function-in-the-early-years-after-delivery
#37
JOURNAL ARTICLE
Abbi Lane, Marcey Jiles, Kaitlyn Ramey, Marnie McLean, Jamie Alexis Whitney, Abigail Brunson, Thomas Cardaci, Jihong Liu, Sara Wilcox, Janet Catov, Bo Fernhall
BACKGROUND: Adverse pregnancy outcomes (APOs: hypertensive disorders, gestational diabetes, preterm birth, placental disorders) are associated with cardiovascular disease risk or blood volume abnormalities. Traditional risk factors might not identify highest risk people in the early years after APO deliveries. PURPOSE: Test the hypothesis that vascular function is worse and plasma volume-regulating renal hormones lower after delivery in people who did versus did not have an APO...
November 3, 2023: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/37859623/effect-of-next-step-antidepressant-treatment-on-suicidal-ideation-findings-from-the-vast-d-trial
#38
JOURNAL ARTICLE
Sidney Zisook, Christine Yu Moutier, A John Rush, Gary R Johnson, Ilanit Tal, P J Chen, Lori L Davis, Paul B Hicks, James Wilcox, Beata Planeta, Kimberly Weingart Lauro, Alexandra A Scrymgeour, John Kasckow, Somaia Mohamed
BACKGROUND: Major depressive disorder (MDD) contributes to suicide risk. Treating MDD effectively is considered a key suicide prevention intervention. Yet many patients with MDD do not respond to their initial medication and require a 'next-step'. The relationship between next-step treatments and suicidal thoughts and behaviors is uncharted. METHOD: The VA Augmentation and Switching Treatments for Depression trial randomized 1522 participants to one of three next-step treatments: Switching to Bupropion, combining with Bupropion, and augmenting with Aripiprazole...
October 20, 2023: Psychological Medicine
https://read.qxmd.com/read/37785379/toxicity-analysis-of-a-modified-prostate-bed-ctv-based-on-psma-pet-patterns-of-failure
#39
JOURNAL ARTICLE
C Montoya, E L Bossart, M Noy, M C Abramowitz, B A Mahal, A Pollack, B Spieler, A Dal Pra
PURPOSE/OBJECTIVE(S): After radical prostatectomy (RP), about 20-50% of prostate cancer patients experience biochemical failure, and many can be cured with salvage radiotherapy (sRT). Adding androgen deprivation and pelvic lymph node (PLN) RT to sRT decreases risk of disease progression at the cost of increased toxicity. PSMA PET patterns of local failure after RP show failures outside the RTOG prostate bed CTV (RTOG_CTV) occurring postero-laterally and inferiorly, while in much of the covered bladder local failures are not seen...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37773841/bioinformatics-analysis-of-copper-death-gene-in-diabetic-immune-infiltration
#40
JOURNAL ARTICLE
Zhimin Lu, Ling Ding, Sen Zhang, Xing Jiang, Qinglu Wang, Ying Luo, Xuewen Tian
BACKGROUND: Copper plays an important role in the human body and is potentially related to the development of diabetes. The mechanism of copper death gene regulating immune infiltration in diabetes has not been studied. METHODS: Download microarray data from healthy normal and diabetic patients from the GEO database. The identification of differentially expressed genes (DEGs) was analyzed by gene enrichment. Using String online database and Cytoscape software to interact with the protein interaction network and make visual analysis...
September 29, 2023: Medicine (Baltimore)
keyword
keyword
5842
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.