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https://www.readbyqxmd.com/read/29132317/development-of-amplicon-deep-sequencing-markers-and-data-analysis-pipeline-for-genotyping-multi-clonal-malaria-infections
#1
Anita Lerch, Cristian Koepfli, Natalie E Hofmann, Camilla Messerli, Stephen Wilcox, Johanna H Kattenberg, Inoni Betuela, Liam O'Connor, Ivo Mueller, Ingrid Felger
BACKGROUND: Amplicon deep sequencing permits sensitive detection of minority clones and improves discriminatory power for genotyping multi-clone Plasmodium falciparum infections. New amplicon sequencing and data analysis protocols are needed for genotyping in epidemiological studies and drug efficacy trials of P. falciparum. METHODS: Targeted sequencing of molecular marker csp and novel marker cpmp was conducted in duplicate on mixtures of parasite culture strains and 37 field samples...
November 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29104905/byte-by-bite-use-of-a-mobile-bite-counter-and-weekly-behavioral-challenges-to-promote-weight-loss
#2
Gabrielle M Turner-McGrievy, Alycia Boutté, Anthony Crimarco, Sara Wilcox, Brent E Hutto, Adam Hoover, Eric R Muth
The goal of this study was to examine the usability and feasibility of the mobile Bite Counter (a watch-like device that detects when a user consumes food or beverage) and the impact of weekly behavioral challenges on diet and physical activity outcomes. Overweight (mean BMI 31.1±4.9 kg/m(2)) adults (n=12) were recruited to participate in a four-week study to test both the usability and feasibility of using the device as part of a behavioral weight loss intervention. Participants were instructed to self-monitor number of bites/day using the Bite Counter, attend weekly group sessions, and listen to weekly podcasts...
September 2017: Smart Health (Amst)
https://www.readbyqxmd.com/read/29092667/manipulating-the-reported-age-in-earliest-memories
#3
Ineke Wessel, Theresa Schweig, Rafaële J C Huntjens
Previous work suggests that the estimated age in adults' earliest autobiographical memories depends on age information implied by the experimental context [e.g., Kingo, O. S., Bohn, A., & Krøjgaard, P. (2013). Warm-up questions on early childhood memories affect the reported age of earliest memories in late adolescence. Memory, 21(2), 280-284. doi: 10.1080/09658211.2012.729598 ] and that the age in decontextualised snippets of memory is younger than in more complete accounts (i.e., event memories [Bruce, D...
November 2, 2017: Memory
https://www.readbyqxmd.com/read/29048969/school-based-curriculum-to-improve-depression-literacy-among-us-secondary-school-students-a-randomized-effectiveness-trial
#4
RANDOMIZED CONTROLLED TRIAL
Karen Swartz, Rashelle J Musci, Mary Beth Beaudry, Kathryn Heley, Leslie Miller, Clarissa Alfes, Lisa Townsend, Graham Thornicroft, Holly C Wilcox
OBJECTIVES: To determine the effectiveness of a universal school-based depression education program. METHODS: In 2012-2015, we matched 6679 students from 66 secondary schools into pairs by state (Maryland, Delaware, Pennsylvania, Michigan, and Oklahoma) and randomized to the Adolescent Depression Awareness Program (ADAP; n = 3681) or to a waitlist control condition (n = 2998). Trained teachers delivered ADAP as part of the health education curriculum to students aged 14 to 15 years...
December 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29032125/rifm-fragrance-ingredient-safety-assessment-tetrahydro-4-methyl-2-2-methylpropen-1-yl-pyran-cas-registry-number-16409-43-1
#5
A M Api, D Belsito, S Bhatia, D Botelho, D Browne, M Bruze, A Burton, J Buschmann, P Calow, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, K Joshi, L Kromidas, S La Cava, J F Lalko, A Lapczynski, D C Liebler, Y Miyachi, D O'brien, R Parakhia, A Patel, T M Penning, V T Politano, G Ritacco, J Romine, D Salvito, T W Schultz, J Shen, I G Sipes, Y Thakkar, Y Tokura, S Tsang, J Wahler, B Wall, D K Wilcox
No abstract text is available yet for this article.
October 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29025969/a-versatile-optical-tool-for-studying-synaptic-gabaa-receptor-trafficking
#6
Joshua M Lorenz-Guertin, Madeleine R Wilcox, Ming Zhang, Mads B Larsen, Jyotsna Pilli, Brigitte F Schmidt, Marcel P Bruchez, Jon W Johnson, Alan S Waggoner, Simon C Watkins, Tija C Jacob
Live-cell imaging methods can provide critical real-time receptor trafficking measurements. Here we describe an optical tool to study synaptic GABAA receptor (GABAAR) dynamics using adaptable fluorescent tracking capabilities. A fluorogen-activating peptide (FAP) was genetically inserted into a γ2 subunit tagged with pH-sensitive green fluorescent protein (γ2(pH)FAP). The FAP selectively binds and activates malachite green (MG) dyes that are otherwise non-fluorescent in solution. γ2(pH)FAP GABAARs are expressed at the cell surface in transfected cortical neurons, form synaptic clusters, and do not perturb neuronal development...
October 12, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29025028/cohort-profile-pregnancy-and-childhood-epigenetics-pace-consortium
#7
Janine F Felix, Bonnie R Joubert, Andrea A Baccarelli, Gemma C Sharp, Catarina Almqvist, Isabella Annesi-Maesano, Hasan Arshad, Nour Baïz, Marian J Bakermans-Kranenburg, Kelly M Bakulski, Elisabeth B Binder, Luigi Bouchard, Carrie V Breton, Bert Brunekreef, Kelly J Brunst, Esteban G Burchard, Mariona Bustamante, Leda Chatzi, Monica Cheng Munthe-Kaas, Eva Corpeleijn, Darina Czamara, Dana Dabelea, George Davey Smith, Patrick De Boever, Liesbeth Duijts, Terence Dwyer, Celeste Eng, Brenda Eskenazi, Todd M Everson, Fahimeh Falahi, M Daniele Fallin, Sara Farchi, Mariana F Fernandez, Lu Gao, Tom R Gaunt, Akram Ghantous, Matthew W Gillman, Semira Gonseth, Veit Grote, Olena Gruzieva, Siri E Håberg, Zdenko Herceg, Marie-France Hivert, Nina Holland, John W Holloway, Cathrine Hoyo, Donglei Hu, Rae-Chi Huang, Karen Huen, Marjo-Riitta Järvelin, Dereje D Jima, Allan C Just, Margaret R Karagas, Robert Karlsson, Wilfried Karmaus, Katerina J Kechris, Juha Kere, Manolis Kogevinas, Berthold Koletzko, Gerard H Koppelman, Leanne K Küpers, Christine Ladd-Acosta, Jari Lahti, Nathalie Lambrechts, Sabine A S Langie, Rolv T Lie, Andrew H Liu, Maria C Magnus, Per Magnus, Rachel L Maguire, Carmen J Marsit, Wendy McArdle, Erik Melén, Phillip Melton, Susan K Murphy, Tim S Nawrot, Lorenza Nisticò, Ellen A Nohr, Björn Nordlund, Wenche Nystad, Sam S Oh, Emily Oken, Christian M Page, Patrice Perron, Göran Pershagen, Costanza Pizzi, Michelle Plusquin, Katri Raikkonen, Sarah E Reese, Eva Reischl, Lorenzo Richiardi, Susan Ring, Ritu P Roy, Peter Rzehak, Greet Schoeters, David A Schwartz, Sylvain Sebert, Harold Snieder, Thorkild I A Sørensen, Anne P Starling, Jordi Sunyer, Jack A Taylor, Henning Tiemeier, Vilhelmina Ullemar, Marina Vafeiadi, Marinus H Van Ijzendoorn, Judith M Vonk, Annette Vriens, Martine Vrijheid, Pei Wang, Joseph L Wiemels, Allen J Wilcox, Rosalind J Wright, Cheng-Jian Xu, Zongli Xu, Ivana V Yang, Paul Yousefi, Hongmei Zhang, Weiming Zhang, Shanshan Zhao, Golareh Agha, Caroline L Relton, Vincent W V Jaddoe, Stephanie J London
No abstract text is available yet for this article.
September 13, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29016858/maternal-bmi-at-the-start-of-pregnancy-and-offspring-epigenome-wide-dna-methylation-findings-from-the-pregnancy-and-childhood-epigenetics-pace-consortium
#8
Gemma C Sharp, Lucas A Salas, Claire Monnereau, Catherine Allard, Paul Yousefi, Todd M Everson, Jon Bohlin, Zongli Xu, Rae-Chi Huang, Sarah E Reese, Cheng-Jian Xu, Nour Baïz, Cathrine Hoyo, Golareh Agha, Ritu Roy, John W Holloway, Akram Ghantous, Simon K Merid, Kelly M Bakulski, Leanne K Küpers, Hongmei Zhang, Rebecca C Richmond, Christian M Page, Liesbeth Duijts, Rolv T Lie, Phillip E Melton, Judith M Vonk, Ellen A Nohr, ClarLynda Williams-DeVane, Karen Huen, Sheryl L Rifas-Shiman, Carlos Ruiz-Arenas, Semira Gonseth, Faisal I Rezwan, Zdenko Herceg, Sandra Ekström, Lisa Croen, Fahimeh Falahi, Patrice Perron, Margaret R Karagas, Bilal M Quraishi, Matthew Suderman, Maria C Magnus, Vincent W V Jaddoe, Jack A Taylor, Denise Anderson, Shanshan Zhao, Henriette A Smit, Michele J Josey, Asa Bradman, Andrea A Baccarelli, Mariona Bustamante, Siri E Håberg, Göran Pershagen, Irva Hertz-Picciotto, Craig Newschaffer, Eva Corpeleijn, Luigi Bouchard, Debbie A Lawlor, Rachel L Maguire, Lisa F Barcellos, George Davey Smith, Brenda Eskenazi, Wilfried Karmaus, Carmen J Marsit, Marie-France Hivert, Harold Snieder, M Daniele Fallin, Erik Melén, Monica C Munthe-Kaas, Hasan Arshad, Joseph L Wiemels, Isabella Annesi-Maesano, Martine Vrijheid, Emily Oken, Nina Holland, Susan K Murphy, Thorkild I A Sørensen, Gerard H Koppelman, John P Newnham, Allen J Wilcox, Wenche Nystad, Stephanie J London, Janine F Felix, Caroline L Relton
Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28982672/sodium-and-fluid-excretion-with-torsemide-in-healthy-subjects-is-limited-by-the-short-duration-of-diuretic-action
#9
Salim Shah, Bertram Pitt, D Craig Brater, Peter U Feig, Wen Shen, Fatima S Khwaja, Christopher S Wilcox
BACKGROUND: Loop diuretics are highly natriuretic but their short duration of action permits postdiuretic sodium retention, which limits salt loss unless dietary salt is severely restricted. We tested the hypothesis that a more prolonged duration of action would enhance salt loss. METHODS AND RESULTS: Ten healthy participants were crossed over between 20 mg of oral immediate-release or extended-release (ER) torsemide while consuming a fixed diet with 300 mmol·d(-1) of Na(+)...
October 5, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28960133/%C3%AE-potential-changing-nanoparticles-as-cystic-fibrosis-transmembrane-conductance-regulator-gene-delivery-system-an-in-vitro-evaluation
#10
Felix Prüfert, Sonja Bonengel, Saskia Köllner, Janine Griesser, Matthew D Wilcox, Peter I Chater, Jeffrey P Pearson, Andreas Bernkop-Schnürch
AIM: Aim of the study was the development of ζ potential changing nanoparticles as gene delivery system for the cystic fibrosis transmembrane conductance regulator gene. METHODS: Chitosan and carboxymethyl cellulose were modified with phosphotyrosine, a substrate for the brush border enzyme alkaline phosphatase. With these synthesized derivatives, different nanoparticle formulations, including the cystic fibrosis transmembrane conductance regulator gene were prepared by ionic gelation...
September 29, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28951466/emergency-department-blood-gas-utilization-and-changes-in-ventilator-settings
#11
Haitham S Al Ashry, Jeremy B Richards, Daniel F Fisher, Jeffrey Sankoff, Todd A Seigel, Lauren B Angotti, Susan R Wilcox
BACKGROUND: Mechanically ventilated patients increasingly spend hours in emergency department beds before ICU admission. This study evaluated the performance of blood gases in mechanically ventilated subjects in the emergency department and subsequent changes to mechanical ventilation settings. METHODS: This was a multi-center, prospective, observational study of subjects ventilated in the emergency department, conducted at 3 academic emergency departments from July 2011 to March 2013...
September 26, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28949521/discovery-of-n-4-2-4-difluorophenoxy-3-6-methyl-7-oxo-6-7-dihydro-1h-pyrrolo-2-3-c-pyridin-4-yl-phenyl-ethanesulfonamide-abbv-075-mivebresib-a-potent-and-orally-available-bromodomain-and-extraterminal-domain-bet-family-bromodomain-inhibitor
#12
Keith F McDaniel, Le Wang, Todd Soltwedel, Steven D Fidanze, Lisa A Hasvold, Dachun Liu, Robert A Mantei, John K Pratt, George S Sheppard, Mai H Bui, Emily J Faivre, Xiaoli Huang, Leiming Li, Xiaoyu Lin, Rongqi Wang, Scott E Warder, Denise Wilcox, Daniel H Albert, Terrance J Magoc, Ganesh Rajaraman, Chang H Park, Charles W Hutchins, Jianwei J Shen, Rohinton P Edalji, Chaohong C Sun, Ruth Martin, Wenqing Gao, Shekman Wong, Guowei Fang, Steven W Elmore, Yu Shen, Warren M Kati
The development of bromodomain and extraterminal domain (BET) bromodomain inhibitors and their examination in clinical studies, particularly in oncology settings, has garnered substantial recent interest. An effort to generate novel BET bromodomain inhibitors with excellent potency and drug metabolism and pharmacokinetics (DMPK) properties was initiated based upon elaboration of a simple pyridone core. Efforts to develop a bidentate interaction with a critical asparagine residue resulted in the incorporation of a pyrrolopyridone core, which improved potency by 9-19-fold...
October 12, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28944007/the-other-white-nose-syndrome-transcriptome-tolerant-and-susceptible-hosts-respond-differently-to-the-pathogen-pseudogymnoascus-destructans
#13
Christina M Davy, Michael E Donaldson, Craig K R Willis, Barry J Saville, Liam P McGuire, Heather Mayberry, Alana Wilcox, Gudrun Wibbelt, Vikram Misra, Trent Bollinger, Christopher J Kyle
Mitigation of emerging infectious diseases that threaten global biodiversity requires an understanding of critical host and pathogen responses to infection. For multihost pathogens where pathogen virulence or host susceptibility is variable, host-pathogen interactions in tolerant species may identify potential avenues for adaptive evolution in recently exposed, susceptible hosts. For example, the fungus Pseudogymnoascus destructans causes white-nose syndrome (WNS) in hibernating bats and is responsible for catastrophic declines in some species in North America, where it was recently introduced...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28935822/effect-of-adipose-tissue-thickness-muscle-site-and-sex-on-near-infrared-spectroscopy-derived-total-hemoglobin-myoglobin
#14
Jesse C Craig, Ryan M Broxterman, Samuel L Wilcox, Chixiang Chen, Thomas J Barstow
Adipose tissue thickness (ATT) attenuates signals from near-infrared spectroscopy (NIRS) and diminishes the absolute quantification of underlying tissues by contemporary NIRS devices. Based on the relationship between NIRS-derived total-[Hemoglobin+Myoglobin] (total-[Hb+Mb]) and ATT, we tested the hypotheses that the correction factor for ATT: 1) is muscle site specific; 2) does not differ between men and women; and 3) exclusion of the shortest source-detector distance from data analysis increases total-[Hb+Mb]...
September 21, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28927560/patient-variation-limits-use-of-fixed-references-for-femoral-rotation-component-alignment-in-total-knee-arthroplasty
#15
Joshua G Twiggs, David M Dickison, Elizabeth C Kolos, Caitlin E Wilcox, Justin P Roe, Brett A Fritsch, Stephen J McMahon, Brad P Miles, Andrew J Ruys
BACKGROUND: Optimal rotational alignment of the femoral component is a common goal during total knee arthroplasty. The posterior condylar axis (PCA) is thought to be the most reproducible reference in surgery, while the transepicondylar axis (TEA) seems to better approximate the native kinematic flexion axis. This study sought to determine if rules based on patient gender or coronal alignment could allow reliable reproduction of the TEA from the PCA. METHODS: Three-dimensional models based on preoperative computed tomography were made representing a patient's arthritic knee joint...
August 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28920097/acute-cd47-blockade-during-ischemic-myocardial-reperfusion-enhances-phagocytosis-associated-cardiac-repair
#16
Shuang Zhang, Xin-Yi Yeap, Matthew DeBerge, Nivedita K Naresh, Kevin Wang, Zhengxin Jiang, Jane E Wilcox, Steven M White, John P Morrow, Paul W Burridge, Daniel Procissi, Evan A Scott, William Frazier, Edward B Thorp
Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased CD47 on the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After myocardial ischemia and reperfusion, acute CD47 inhibition with blocking antibodies enhanced dead myocyte clearance by cardiac phagocytes and also improved the resolution of cardiac inflammation, reduced infarct size, and preserved cardiac contractile function. Early targeting of CD47 in the myocardium after reperfusion may be a new strategy to enhance wound repair in the ischemic heart...
August 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28898263/genome-wide-analysis-of-parent-of-origin-interaction-effects-with-environmental-exposure-pooxe-an-application-to-european-and-asian-cleft-palate-trios
#17
Øystein A Haaland, Astanand Jugessur, Miriam Gjerdevik, Julia Romanowska, Min Shi, Terri H Beaty, Mary L Marazita, Jeffrey C Murray, Allen J Wilcox, Rolv T Lie, Håkon K Gjessing
Cleft palate only is a common birth defect with high heritability. Only a small fraction of this heritability is explained by the genetic variants identified so far, underscoring the need to investigate other disease mechanisms, such as gene-environment (GxE) interactions and parent-of-origin (PoO) effects. Furthermore, PoO effects may vary across exposure levels (PoOxE effects). Such variation is the focus of this study. We upgraded the R-package Haplin to enable direct tests of PoOxE effects at the genome-wide level...
2017: PloS One
https://www.readbyqxmd.com/read/28858939/beyond-abdominal-pain-pain-beliefs-pain-affect-and-distress-as-determinants-of-quality-of-life-in-patients-with-chronic-pancreatitis
#18
Craig E Keller, Charles Mel Wilcox, Gregory D Gudleski, Stacey Branham, Jeffrey M Lackner
GOALS: To assess the relationship between pain, psychological processes, and quality of life (QOL) in chronic pancreatitis (CP). BACKGROUND: CP is a progressive inflammatory disorder of the pancreas characteristically resulting in abdominal pain and impairing QOL. Pain due to CP is poorly understood and frequently difficult to treat. This pain has historically been understood as a peripheral process originating from the pancreas itself, but a growing body of literature is revealing an important role offered by central influences...
August 30, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28846038/a-case-controlled-investigation-of-tactile-reactivity-in-young-children-with-and-without-global-developmental-delay
#19
Chantel C Barney, Raymond Tervo, George L Wilcox, Frank J Symons
Assessing tactile function among children with intellectual, motor, and communication impairments remains a clinical challenge. A case control design was used to test whether children with global developmental delays (GDD; n = 20) would be more/less reactive to a modified quantitative sensory test (mQST) compared to controls (n = 20). Reactivity was indexed by blinded behavioral coding across vocal, facial, and gross motor responses during the mQST. On average the children with GDD were significantly more reactive than controls to most tactile sensory modalities including light touch (p = ...
September 2017: American Journal on Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/28843850/substance-use-disorders-in-adolescent-and-young-adult-relatives-of-probands-with-bipolar-disorder-what-drives-the-increased-risk
#20
Leslie A Hulvershorn, Jennifer King, Patrick O Monahan, Holly C Wilcox, Philip B Mitchell, Janice M Fullerton, Howard J Edenberg, Gloria M P Roberts, Masoud Kamali, Anne L Glowinski, Neera Ghaziuddin, Melvin McInnis, Priya A Iyer-Eimerbrink, John I Nurnberger
BACKGROUND: Adults with bipolar disorder (BD) have higher rates of substance use disorders (SUDs) compared to the general population. SUD rates in young offspring/relatives of BD probands, as well as factors which drive those rates, are not as well-characterized. METHODS: We aimed to examine SUD prevalence among adolescent/young adult offspring and relatives of probands with and without BD. Data were collected from five sites in the US and Australia during 2006-2011...
October 2017: Comprehensive Psychiatry
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