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https://www.readbyqxmd.com/read/28323905/elevated-plasma-levels-of-cardiac-troponin-i-predict-left-ventricular-systolic-dysfunction-in-patients-with-myotonic-dystrophy-type-1-a-multicentre-cohort-follow-up-study
#1
Mark J Hamilton, Yvonne Robb, Sarah Cumming, Helen Gregory, Alexis Duncan, Monika Rahman, Anne McKeown, Catherine McWilliam, John Dean, Alison Wilcox, Maria E Farrugia, Anneli Cooper, Josephine McGhie, Berit Adam, Richard Petty, Cheryl Longman, Iain Findlay, Alan Japp, Darren G Monckton, Martin A Denvir
OBJECTIVE: High sensitivity plasma cardiac troponin-I (cTnI) is emerging as a strong predictor of cardiac events in a variety of settings. We have explored its utility in patients with myotonic dystrophy type 1 (DM1). METHODS: 117 patients with DM1 were recruited from routine outpatient clinics across three health boards. A single measurement of cTnI was made using the ARCHITECT STAT Troponin I assay. Demographic, ECG, echocardiographic and other clinical data were obtained from electronic medical records...
2017: PloS One
https://www.readbyqxmd.com/read/28287095/aboriginal-australian-mitochondrial-genome-variation-an-increased-understanding-of-population-antiquity-and-diversity
#2
Nano Nagle, Mannis van Oven, Stephen Wilcox, Sheila van Holst Pellekaan, Chris Tyler-Smith, Yali Xue, Kaye N Ballantyne, Leah Wilcox, Luka Papac, Karen Cooke, Roland A H van Oorschot, Peter McAllister, Lesley Williams, Manfred Kayser, R John Mitchell
Aboriginal Australians represent one of the oldest continuous cultures outside Africa, with evidence indicating that their ancestors arrived in the ancient landmass of Sahul (present-day New Guinea and Australia) ~55 thousand years ago. Genetic studies, though limited, have demonstrated both the uniqueness and antiquity of Aboriginal Australian genomes. We have further resolved known Aboriginal Australian mitochondrial haplogroups and discovered novel indigenous lineages by sequencing the mitogenomes of 127 contemporary Aboriginal Australians...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28279898/concern-about-developing-alzheimer-s-disease-or-dementia-and-intention-to-be-screened-an-analysis-of-national-survey-data
#3
Weizhou Tang, Kristie Kannaley, Daniela B Friedman, Valerie J Edwards, Sara Wilcox, Sue E Levkoff, Rebecca H Hunter, Cheryl Irmiter, Basia Belza
OBJECTIVE: Early diagnosis of Alzheimer's disease (AD) or dementia is important so that patients can express treatment preferences, subsequently allowing caregivers to make decisions consistent with their wishes. This study explored the relationship between people's concern about developing AD/dementia, likelihood to be screened/tested, if experiencing changes in cognitive status or functioning, and concerns about sharing the diagnostic information with others. METHOD: A descriptive study was conducted using Porter Novelli's SummerStyles 2013 online survey data...
March 1, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28269681/a-three-element-1h-31p-dual-tuned-array-for-magnetic-resonance-spectroscopy-at-4-7-t
#4
Matthew D Wilcox, Romina Del Bosque, Kurt Parizek, Jeremy Sia, Edwin D Eigenbrodt, Mary P McDougall
This work describes the construction and testing of a three-element, double-tuned receive array and transmit coils for 31P-1H spectroscopy and imaging. The receive coils were geometrically-decoupled, single-loop surface coils and the transmit coils were concentric saddle coils. The coils were used to examine a physiologically-modeled CNC-milled phantom. The receive coil array was able to improve SNR while also providing gross localization of the 1H and 31P signals.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269680/effects-of-coplanar-shielding-for-high-field-mri
#5
Joseph V Rispoli, Matthew D Wilcox, Samantha By, Steven M Wright, Mary P McDougall
This work investigates the efficacy of "coplanar shielding," in which copper shields are oriented concentric and coplanar to the RF coils rather than implemented as a full ground plane behind them. Following FDTD simulations to determine optimal shielding parameters, two coil geometries were constructed: a circular loop surface coil and a half-volume five-element receive array. Each was evaluated using bench measurements with and without coplanar shielding. Imaging, including accelerated SENSE imaging, was performed with the shielded and unshielded receive arrays on a whole-body 7T scanner...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263866/rifm-fragrance-ingredient-safety-assessment-d-cyclocitronellene-acetate-cas-registry-number-25225-10-9
#6
A M Api, D Belsito, S Bhatia, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, P Calow, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, L Kromidas, S La Cava, J Lalko, A Lapczynski, D C Liebler, Y Miyachi, D O'brien, R Parakhia, A Patel, T M Penning, V T Politano, G Ritacco, J Romine, D Salvito, T W Schultz, J Shen, I G Sipes, Y Thakkar, S Tsang, J Wahler, B Wall, D K Wilcox
No abstract text is available yet for this article.
March 2, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28245999/rifm-fragrance-ingredient-safety-assessment-isolongifolene-ketone-cas-registry-number-23787-90-8
#7
A M Api, D Belsito, S Bhatia, D Botelho, D Brown, M Bruze, G A Burton, J Buschmann, P Calow, M L Dagli, M Date, W Dekant, A D Fryer, L Kromidas, J Lalko, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, V T Politano, G Ritacco, J Romine, D Salvito, T W Schultz, J Shen, I G Sipes, Y Thakkar, J Wahler, B Wall, D K Wilcox
No abstract text is available yet for this article.
February 25, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28244497/quality-of-life-in-chronic-pancreatitis-is-determined-by-constant-pain-disability-unemployment-current-smoking-and-associated-co-morbidities
#8
Jorge D Machicado, Stephen T Amann, Michelle A Anderson, Judah Abberbock, Stuart Sherman, Darwin L Conwell, Gregory A Cote, Vikesh K Singh, Michele D Lewis, Samer Alkaade, Bimaljit S Sandhu, Nalini M Guda, Thiruvengadam Muniraj, Gong Tang, John Baillie, Randall E Brand, Timothy B Gardner, Andres Gelrud, Christopher E Forsmark, Peter A Banks, Adam Slivka, C Mel Wilcox, David C Whitcomb, Dhiraj Yadav
OBJECTIVES: Chronic pancreatitis (CP) has a profound independent effect on quality of life (QOL). Our aim was to identify factors that impact the QOL in CP patients. METHODS: We used data on 1,024 CP patients enrolled in the three NAPS2 studies. Information on demographics, risk factors, co-morbidities, disease phenotype, and treatments was obtained from responses to structured questionnaires. Physical and mental component summary (PCS and MCS, respectively) scores generated using responses to the Short Form-12 (SF-12) survey were used to assess QOL at enrollment...
February 28, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28242154/systematic-review-and-meta-analysis-of-the-effect-of-internal-iliac-artery-exclusion-for-patients-undergoing-evar
#9
REVIEW
D C Bosanquet, C Wilcox, L Whitehurst, A Cox, I M Williams, C P Twine
OBJECTIVE: Endovascular abdominal aortic aneurysm repair (EVAR) sometimes requires internal iliac artery (IIA) coverage to achieve a landing zone in the external iliac artery. The aim of this study was to determine complication rates following IIA exclusion. MATERIALS AND METHODS: A systematic review of key journals was undertaken from January 1980 to April 2016. Studies detailing occlusion (using coils or plugs) or coverage of the IIA with outcome data were included...
February 24, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28231626/default-mode-network-deactivation-to-smoking-cue-relative-to-food-cue-predicts-treatment-outcome-in-nicotine-use-disorder
#10
Claire E Wilcox, Eric D Claus, Vince D Calhoun, Srinivas Rachakonda, Rae A Littlewood, Jessica Mickey, Pamela B Arenella, Natalie Goodreau, Kent E Hutchison
Identifying predictors of treatment outcome for nicotine use disorders (NUDs) may help improve efficacy of established treatments, like varenicline. Brain reactivity to drug stimuli predicts relapse risk in nicotine and other substance use disorders in some studies. Activity in the default mode network (DMN) is affected by drug cues and other palatable cues, but its clinical significance is unclear. In this study, 143 individuals with NUD (male n = 91, ages 18-55 years) received a functional magnetic resonance imaging scan during a visual cue task during which they were presented with a series of smoking-related or food-related video clips prior to randomization to treatment with varenicline (n = 80) or placebo...
February 23, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28230419/the-association-between-physical-performance-and-executive-function-in-a-sample-of-rural-older-adults-from-south-carolina-usa
#11
Ryan S Falck, Sara Wilcox, John R Best, Jessica L Chandler, Teresa Liu-Ambrose
BACKGROUND: Mobility and executive functions (EFs) decline with age, although associations between mobility and EFs are less clear. This study examined relationships between different mobility measures and EFs among rural older adults. METHODS: This cross-sectional study recruited 56 older adults (60+ years) in rural South Carolina. Mobility was assessed via gait speed, timed up-and-go, chair stand, and as a composite physical performance score (PPS). EFs was assessed via Trail Making Test, semantic fluency, and phonemic fluency...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28227941/a-three-element-1-h-31-p-dual-tuned-array-for-magnetic-resonance-spectroscopy-at-4-7-t
#12
Matthew D Wilcox, Romina Del Bosque, Kurt Parizek, Jeremy Sia, Edwin D Eigenbrodt, Mary P McDougall, Matthew D Wilcox, Romina Del Bosque, Kurt Parizek, Jeremy Sia, Edwin D Eigenbrodt, Mary P McDougall, Jeremy Sia, Romina Del Bosque, Kurt Parizek, Mary P McDougall, Matthew D Wilcox, Edwin D Eigenbrodt
This work describes the construction and testing of a three-element, double-tuned receive array and transmit coils for (31)P-(1)H spectroscopy and imaging. The receive coils were geometrically-decoupled, single-loop surface coils and the transmit coils were concentric saddle coils. The coils were used to examine a physiologically-modeled CNC-milled phantom. The receive coil array was able to improve SNR while also providing gross localization of the (1)H and (31)P signals.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227939/effects-of-coplanar-shielding-for-high-field-mri
#13
Joseph V Rispoli, Matthew D Wilcox, Samantha By, Steven M Wright, Mary P McDougall, Joseph V Rispoli, Matthew D Wilcox, Samantha By, Steven M Wright, Mary P McDougall, Matthew D Wilcox, Steven M Wright, Samantha By, Mary P McDougall, Joseph V Rispoli
This work investigates the efficacy of "coplanar shielding," in which copper shields are oriented concentric and coplanar to the RF coils rather than implemented as a full ground plane behind them. Following FDTD simulations to determine optimal shielding parameters, two coil geometries were constructed: a circular loop surface coil and a half-volume five-element receive array. Each was evaluated using bench measurements with and without coplanar shielding. Imaging, including accelerated SENSE imaging, was performed with the shielded and unshielded receive arrays on a whole-body 7T scanner...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222797/melanoma-antigen-specific-effector-t-cell-cytokine-secretion-patterns-in-patients-treated-with-ipilimumab
#14
Yana G Najjar, Fei Ding, Yan Lin, Robert VanderWeele, Lisa H Butterfield, Ahmad A Tarhini
BACKGROUND: In a previously reported study, patients with regionally advanced melanoma were treated with neoadjuvant ipilimumab (ipi) (Tarhini in PLoS ONE 9(2): e87705, 3). Significant changes in circulating myeloid derived suppressor cells (MDSC), regulatory T cells (Treg) and peptide specific type I CD4(+) and CD8(+) T cells were noted at week 6 that correlated with clinical outcome. Characterization of antigen-specific effector T cell secreted cytokines may shed insights into ipi associated T cell activation and function...
February 21, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28219699/rifm-fragrance-ingredient-safety-assessment-isobornyl-2-methylpropionate-cas-registry-number-85586-67-0
#15
A M Api, D Belsito, S Bhatia, M Bruze, P Calow, M L Dagli, W Dekant, A D Fryer, L Kromidas, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, T M Penning, V T Politano, G Ritacco, D Salvito, T W Schultz, J Shen, I G Sipes, B Wall, D K Wilcox
No abstract text is available yet for this article.
February 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28213939/protective-antibodies-against-clostridium-difficile-are-present-in-intravenous-immunoglobulin-and-are-retained-in-humans-following-its-administration
#16
Ola H Negm, Brendon MacKenzie, Mohamed R Hamed, Omar Aj Ahmad, Clifford C Shone, David P Humphreys, K Ravi Acharya, Christine E Loscher, Izabela Marszalowska, Mark Lynch, Mark H Wilcox, Tanya M Monaghan
The prevalence of serum antibodies against C. difficile (CD) toxins A and B in healthy populations have prompted interest in evaluating the therapeutic activity of intravenous immunoglobulin (IVIg) in individuals experiencing severe or recurrent C. difficile infection (CDI). Despite some promising case reports, a definitive clinical role for IVIg in CDI remains unclear. Contradictory results may be attributed to a lack of consensus regarding optimal dose, timing of administration and patient selection as well as variability in specific antibody content between commercial preparations...
February 18, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28190700/epidemiology-of-escherichia-coli-bacteraemia-in-england-results-of-an-enhanced-sentinel-surveillance-programme
#17
J Abernethy, R Guy, E A Sheridan, S Hopkins, M Kiernan, M H Wilcox, A P Johnson, R Hope
BACKGROUND: Escherichia coli causes more than one-third of the bacteraemia cases in England each year, and the incidence of these infections is increasing. AIM: To determine the underlying risk factors associated with E. coli bacteraemia. METHODS: A three-month enhanced sentinel surveillance study involving 35 National Health Service hospitals was undertaken in the winter of 2012/13 to collect risk factor information and further details on the underlying source of infection to augment data already collected by the English national surveillance programme...
December 16, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28178305/clinical-utility-of-c-reactive-protein-to-predict-treatment-response-during-cystic-fibrosis-pulmonary-exacerbations
#18
Ashutosh Sharma, Gordon Kirkpatrick, Virginia Chen, Kate Skolnik, Zsuzsanna Hollander, Pearce Wilcox, Bradley S Quon
RATIONALE: C-reactive protein (CRP) is a systemic marker of inflammation that correlates with disease status in cystic fibrosis (CF). The clinical utility of CRP measurement to guide pulmonary exacerbation (PEx) treatment decisions remains uncertain. OBJECTIVES: To determine whether monitoring CRP during PEx treatment can be used to predict treatment response. We hypothesized that early changes in CRP can be used to predict treatment response. METHODS: We reviewed all PEx events requiring hospitalization for intravenous (IV) antibiotics over 2 years at our institution...
2017: PloS One
https://www.readbyqxmd.com/read/28177174/a-case-controlled-comparison-of-postoperative-analgesic-dosing-between-girls-with-rett-syndrome-and-girls-with-and-without-developmental-disability-undergoing-spinal-fusion-surgery
#19
Chantel C Barney, Alyssa M Merbler, Kelsey Quest, Breanne J Byiers, George L Wilcox, Scott Schwantes, Samuel A Roiko, Timothy Feyma, Arthur Beisang, Frank J Symons
BACKGROUND: Rett syndrome is associated with severe motor and communicative impairment making optimal postoperative pain management a challenge. There are case reports documenting reduced postoperative analgesic requirement in Rett syndrome. AIM: The goal of this preliminary investigation was to compare postoperative analgesic management among a sample of girls with Rett syndrome compared to girls with and without developmental disability undergoing spinal fusion surgery...
March 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28165208/offspring-birthweight-by-gestational-age-and-parental-cardiovascular-mortality-a-population-based-cohort-study
#20
N-H Morken, F Halland, L A DeRoo, A J Wilcox, R Skjaerven
OBJECTIVE: To estimate risk of parental cardiovascular disease mortality by offspring birthweight. DESIGN: Population-based cohort study. SETTING AND POPULATION: Norwegian mothers and fathers with singleton births during 1967-2002 were followed until 2009 by linkage to the Norwegian cause of death registry. METHODS: Hazard ratios by offspring absolute birthweight in grams and birthweight adjusted for gestational age (z-score) were calculated using Cox regression and adjusted for parental age at delivery and year of first birth...
February 6, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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