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https://www.readbyqxmd.com/read/28213939/protective-antibodies-against-clostridium-difficile-are-present-in-intravenous-immunoglobulin-and-are-retained-in-humans-following-its-administration
#1
Ola H Negm, Brendon MacKenzie, Mohamed R Hamed, Omar Aj Ahmad, Clifford C Shone, David P Humphreys, K Ravi Acharya, Christine E Loscher, Izabela Marszalowska, Mark Lynch, Mark H Wilcox, Tanya M Monaghan
The prevalence of serum antibodies against C. difficile (CD) toxins A and B in healthy populations have prompted interest in evaluating the therapeutic activity of intravenous immunoglobulin (IVIg) in individuals experiencing severe or recurrent C. difficile infection (CDI). Despite some promising case reports, a definitive clinical role for IVIg in CDI remains unclear. Contradictory results may be attributed to a lack of consensus regarding optimal dose, timing of administration and patient selection as well as variability in specific antibody content between commercial preparations...
February 18, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28190700/epidemiology-of-escherichia-coli-bacteraemia-in-england-results-of-an-enhanced-sentinel-surveillance-programme
#2
J Abernethy, R Guy, E A Sheridan, S Hopkins, M Kiernan, M H Wilcox, A P Johnson, R Hope
BACKGROUND: Escherichia coli causes more than one-third of the bacteraemia cases in England each year, and the incidence of these infections is increasing. AIM: To determine the underlying risk factors associated with E. coli bacteraemia. METHODS: A three-month enhanced sentinel surveillance study involving 35 National Health Service hospitals was undertaken in the winter of 2012/13 to collect risk factor information and further details on the underlying source of infection to augment data already collected by the English national surveillance programme...
December 16, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28178305/clinical-utility-of-c-reactive-protein-to-predict-treatment-response-during-cystic-fibrosis-pulmonary-exacerbations
#3
Ashutosh Sharma, Gordon Kirkpatrick, Virginia Chen, Kate Skolnik, Zsuzsanna Hollander, Pearce Wilcox, Bradley S Quon
RATIONALE: C-reactive protein (CRP) is a systemic marker of inflammation that correlates with disease status in cystic fibrosis (CF). The clinical utility of CRP measurement to guide pulmonary exacerbation (PEx) treatment decisions remains uncertain. OBJECTIVES: To determine whether monitoring CRP during PEx treatment can be used to predict treatment response. We hypothesized that early changes in CRP can be used to predict treatment response. METHODS: We reviewed all PEx events requiring hospitalization for intravenous (IV) antibiotics over 2 years at our institution...
2017: PloS One
https://www.readbyqxmd.com/read/28177174/a-case-controlled-comparison-of-postoperative-analgesic-dosing-between-girls-with-rett-syndrome-and-girls-with-and-without-developmental-disability-undergoing-spinal-fusion-surgery
#4
Chantel C Barney, Alyssa M Merbler, Kelsey Quest, Breanne J Byiers, George L Wilcox, Scott Schwantes, Samuel A Roiko, Timothy Feyma, Arthur Beisang, Frank J Symons
BACKGROUND: Rett syndrome is associated with severe motor and communicative impairment making optimal postoperative pain management a challenge. There are case reports documenting reduced postoperative analgesic requirement in Rett syndrome. AIM: The goal of this preliminary investigation was to compare postoperative analgesic management among a sample of girls with Rett syndrome compared to girls with and without developmental disability undergoing spinal fusion surgery...
February 8, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28165208/offspring-birthweight-by-gestational-age-and-parental-cardiovascular-mortality-a-population-based-cohort-study
#5
N-H Morken, F Halland, L A DeRoo, A J Wilcox, R Skjaerven
OBJECTIVE: To estimate risk of parental cardiovascular disease mortality by offspring birthweight. DESIGN: Population-based cohort study. SETTING AND POPULATION: Norwegian mothers and fathers with singleton births during 1967-2002 were followed until 2009 by linkage to the Norwegian cause of death registry. METHODS: Hazard ratios by offspring absolute birthweight in grams and birthweight adjusted for gestational age (z-score) were calculated using Cox regression and adjusted for parental age at delivery and year of first birth...
February 6, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28156596/impact-of-support-group-participation-in-women-with-gynecologic-cancer
#6
Adam Pyrzak, Fengjiao Hu, Ramses F Sadek, Donna Wheatley, Bunja Jane Rungruang, Sharad A Ghamande
: 252 Background: Unlike breast cancer support group literature, there is no data in women with gynecologic cancer who have different perspectives about their disease and therapy. We have a well-established, grass root level support group unique to women with gynecologic cancers that meets monthly. Our goal was to investigate perceived benefits of support group participation. METHODS: We developed an original questionnaire to evaluate the CSRA Gynecologic Oncology Support Group (CGOSG) participant's perceived effects of attending the group on their side effects and disease status which was distributed to patients attending CGOSG meetings...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28135709/acute-kidney-injury-and-in-hospital-mortality-after-coronary-artery-bypass-graft-versus-percutaneous-coronary-intervention-a-nationwide-study
#7
Wen Shen, Rodrigo Aguilar, Alex R Montero, Stephen J Fernandez, Allen J Taylor, Christopher S Wilcox, Michael S Lipkowitz, Jason G Umans
BACKGROUND: Post-procedural acute kidney injury (AKI) is associated with significantly increased short- and long-term mortalities, and renal loss. Few studies have compared the incidence of post-procedural AKI and in-hospital mortality between 2 major modalities of revascularization - coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) - and results have been inconsistent. METHODS: We generated a propensity score-matched cohort that includes a total of 286,670 hospitalizations with multi-vessel coronary disease undergoing CABG or PCI (2004-2012) from the National Inpatient Sample database...
January 31, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28130063/effects-of-control-interventions-on-clostridium-difficile-infection-in-england-an-observational-study
#8
Kate E Dingle, Xavier Didelot, T Phuong Quan, David W Eyre, Nicole Stoesser, Tanya Golubchik, Rosalind M Harding, Daniel J Wilson, David Griffiths, Alison Vaughan, John M Finney, David H Wyllie, Sarah J Oakley, Warren N Fawley, Jane Freeman, Kirsti Morris, Jessica Martin, Philip Howard, Sherwood Gorbach, Ellie J C Goldstein, Diane M Citron, Susan Hopkins, Russell Hope, Alan P Johnson, Mark H Wilcox, Timothy E A Peto, A Sarah Walker, Derrick W Crook
BACKGROUND: The control of Clostridium difficile infections is an international clinical challenge. The incidence of C difficile in England declined by roughly 80% after 2006, following the implementation of national control policies; we tested two hypotheses to investigate their role in this decline. First, if C difficile infection declines in England were driven by reductions in use of particular antibiotics, then incidence of C difficile infections caused by resistant isolates should decline faster than that caused by susceptible isolates across multiple genotypes...
January 24, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28129423/novel-pex11b-mutations-extend-the-peroxisome-biogenesis-disorder-14b-phenotypic-spectrum-and-underscore-congenital-cataract-as-an-early-feature
#9
Rachel L Taylor, Mark T Handley, Sarah Waller, Christopher Campbell, Jill Urquhart, Alison M Meynert, Jamie M Ellingford, Deirdre Donnelly, Gisela Wilcox, I Chris Lloyd, Helen Mundy, David R FitzPatrick, Charu Deshpande, Jill Clayton-Smith, Graeme C Black
Purpose: Peroxisomes perform complex metabolic and catabolic functions essential for normal growth and development. Mutations in 14 genes cause a spectrum of peroxisomal disease in humans. Most recently, PEX11B was associated with an atypical peroxisome biogenesis disorder (PBD) in a single individual. In this study, we identify further PEX11B cases and delineate associated phenotypes. Methods: Probands from three families underwent next generation sequencing (NGS) for diagnosis of a multisystem developmental disorder...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28121498/bezlotoxumab-for-prevention-of-recurrent-clostridium-difficile-infection
#10
RANDOMIZED CONTROLLED TRIAL
Mark H Wilcox, Dale N Gerding, Ian R Poxton, Ciaran Kelly, Richard Nathan, Thomas Birch, Oliver A Cornely, Galia Rahav, Emilio Bouza, Christine Lee, Grant Jenkin, Werner Jensen, You-Sun Kim, Junichi Yoshida, Lori Gabryelski, Alison Pedley, Karen Eves, Robert Tipping, Dalya Guris, Nicholas Kartsonis, Mary-Beth Dorr
Background Clostridium difficile is the most common cause of infectious diarrhea in hospitalized patients. Recurrences are common after antibiotic therapy. Actoxumab and bezlotoxumab are human monoclonal antibodies against C. difficile toxins A and B, respectively. Methods We conducted two double-blind, randomized, placebo-controlled, phase 3 trials, MODIFY I and MODIFY II, involving 2655 adults receiving oral standard-of-care antibiotics for primary or recurrent C. difficile infection. Participants received an infusion of bezlotoxumab (10 mg per kilogram of body weight), actoxumab plus bezlotoxumab (10 mg per kilogram each), or placebo; actoxumab alone (10 mg per kilogram) was given in MODIFY I but discontinued after a planned interim analysis...
26, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28118783/computerized-tomography-angiography-by-direct-intra-aortic-low-volume-contrast-injection-in-patients-being-evaluated-for-evar
#11
Pedro Gr Teixeira, Leonardo C Clavijo, Alison G Wilcox, Fred A Weaver
Background Computerized tomography angiography is an important tool for endovascular repair of abdominal aortic aneurysm planning. This study aimed to evaluate the utility of computerized tomography angiography using direct intra-aortic injection of low volume of iodinated contrast in patients being considered for endovascular repair of abdominal aortic aneurysm. Design A 5F high-flow angiographic catheter was positioned in the mid-thoracic aorta through femoral percutaneous access. Computerized tomography angiography was performed with image acquisition starting simultaneously with power injection of 10 mL of iopamidol 76% diluted with normal saline to 50 mL, at 6 mL/s through the angiographic catheter...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28118657/association-of-intensive-care-unit-patient-to-intensivist-ratios-with-hospital-mortality
#12
Hayley B Gershengorn, David A Harrison, Allan Garland, M Elizabeth Wilcox, Kathryn M Rowan, Hannah Wunsch
Importance: The patient-to-intensivist ratio (PIR) across intensive care units (ICUs) is not standardized and the association of PIR with patient outcome is not well established. Understanding the impact of PIR on outcomes is necessary to optimize senior medical staffing and deliver high-quality care. Objective: To test the hypotheses that: (1) there is significant variation in the PIR across ICUs and (2) higher PIRs are associated with higher hospital mortality for ICU patients...
January 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28044188/metal-implants-on-ct-comparison-of-iterative-reconstruction-algorithms-for-reduction-of-metal-artifacts-with-single-energy-and-spectral-ct-scanning-in-a-phantom-model
#13
Jieming Fang, Da Zhang, Carol Wilcox, Benedikt Heidinger, Vassilios Raptopoulos, Alexander Brook, Olga R Brook
PURPOSE: To assess single energy metal artifact reduction (SEMAR) and spectral energy metal artifact reduction (MARS) algorithms in reducing artifacts generated by different metal implants. MATERIALS AND METHOD: Phantom was scanned with and without SEMAR (Aquilion One, Toshiba) and MARS (Discovery CT750 HD, GE), with various metal implants. Images were evaluated objectively by measuring standard deviation in regions of interests and subjectively by two independent reviewers grading on a scale of 0 (no artifact) to 4 (severe artifact)...
January 2, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28030955/reno-cerebral-reflex-activates-the-renin-angiotensin-system-promoting-oxidative-stress-and-renal-damage-after-ischemia-reperfusion-injury
#14
Wei Cao, Aiqing Li, Jiawen Li, Chunyi Wu, Shuang Cui, Zhanmei Zhou, Youhua Liu, Christopher S Wilcox, Fan Fan Hou
AIMS: A kidney-brain interaction has been described in acute kidney injury, but the mechanisms are uncertain. Since we recently described a reno-cerebral reflex, we tested the hypothesis that renal ischemia-reperfusion injury (IRI) activates a sympathetic reflex that interlinks the renal and cerebral renin-angiotensin axis to promote oxidative stress and progression of the injury. RESULTS: Bilateral ischemia-reperfusion activated the intrarenal and cerebral, but not the circulating, renin-angiotensin system (RAS), increased sympathetic activity in the kidney and the cerebral sympathetic regulatory regions, and induced brain inflammation and kidney injury...
January 31, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28029193/disturbance-and-productivity-interactions-mediate-stability-of-forest-composition-and-structure
#15
Christopher D O'Connor, Donald A Falk, Ann M Lynch, Thomas W Swetnam, Craig P Wilcox
Fire is returning to many conifer dominated forests where species composition and structure have been altered by fire exclusion. Ecological effects of these fires are influenced strongly by the degree of forest change during the fire-free period. Response of fire-adapted species assemblages to extended fire-free intervals is highly variable, even in communities with similar historical fire regimes. This variability in plant community response to fire exclusion is not well understood; however, ecological mechanisms such as individual species' adaptations to disturbance or competition, and underlying site characteristics that facilitate or impede establishment and growth have been proposed as potential drivers of assemblage response...
December 28, 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27997474/the-effects-of-a-park-awareness-campaign-on-rural-park-use-and-physical-activity
#16
Jorge A Banda, Steven P Hooker, Sara Wilcox, Natalie Colabianchi, Andrew T Kaczynski, James Hussey
To examine the effects of a park awareness campaign on park use in 6 community parks. One-group pretest-posttest design. Six community parks located in a South Carolina county. Children, adolescents, and adults observed in community parks. A 1-month awareness campaign that culminated in single 1.5-hour events at 6 parks in April 2011 and May 2011. The System for Observing Play and Recreation in Communities was used to objectively measure park use in May 2010 (baseline) and May 2011 (postcampaign). Zero-inflated Poisson models tested whether the number of total park users and the number of park users engaged in sedentary, walking, and vigorous activities differed by observation date...
December 16, 2016: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/27987074/medical-students-perceptions-of-the-patient-centredness-of-the-learning-environment
#17
Mark V Wilcox, Megan S Orlando, Cynthia S Rand, Janet Record, Colleen Christmas, Roy C Ziegelstein, Laura A Hanyok
BACKGROUND: Patient-centred care is an important aspect of quality health care. The learning environment may impact medical students' adoption of patient-centred behaviours. METHODS: All medical students at a single institution received an anonymous, modified version of the Communication, Curriculum, and Culture instrument that measures patient-centredness in the training environment along three domains: role modelling, students' experience, and support for patient-centred behaviours...
February 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/27979778/rifm-fragrance-ingredient-safety-assessment-5-ethylidenebicyclo-2-2-1-hept-2-yl-propionate-cas-registry-number-73347-77-0
#18
A M Api, D Belsito, S Bhatia, M Bruze, P Calow, M L Dagli, W Dekant, A D Fryer, L Kromidas, S La Cava, J F Lalko, A Lapczynski, D C Liebler, Y Miyachi, V T Politano, G Ritacco, D Salvito, T W Schultz, J Shen, I G Sipes, B Wall, D K Wilcox
No abstract text is available yet for this article.
December 12, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27978569/outcomes-of-the-veterans-affairs-low-vision-intervention-trial-ii-lovit-ii-a-randomized-clinical-trial
#19
Joan A Stelmack, X Charlene Tang, Yongliang Wei, Denise Thomas Wilcox, Timothy Morand, Karen Brahm, Scott Sayers, Robert W Massof
Importance: Randomized clinical trials are needed to compare effectiveness and cost-effectiveness of different low-vision (LV) programs. Objective: To determine the value of adding LV rehabilitation with a therapist compared with LV services without intervention. Design, Setting, and Participants: A randomized clinical trial was conducted from September 27, 2010, to July 31, 2014, of 323 veterans with macular diseases and best-corrected distance visual acuity (BCDVAbetter-eye) of 20/50 to 20/200...
December 15, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27904152/mitochondrial-dna-diversity-of-present-day-aboriginal-australians-and-implications-for-human-evolution-in-oceania
#20
Nano Nagle, Kaye N Ballantyne, Mannis van Oven, Chris Tyler-Smith, Yali Xue, Stephen Wilcox, Leah Wilcox, Rust Turkalov, Roland A H van Oorschot, Sheila van Holst Pellekaan, Theodore G Schurr, Peter McAllister, Lesley Williams, Manfred Kayser, R John Mitchell
Aboriginal Australians are one of the more poorly studied populations from the standpoint of human evolution and genetic diversity. Thus, to investigate their genetic diversity, the possible date of their ancestors' arrival and their relationships with neighboring populations, we analyzed mitochondrial DNA (mtDNA) diversity in a large sample of Aboriginal Australians. Selected mtDNA single-nucleotide polymorphisms and the hypervariable segment haplotypes were analyzed in 594 Aboriginal Australians drawn from locations across the continent, chiefly from regions not previously sampled...
December 1, 2016: Journal of Human Genetics
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