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A J Spittle, J Olsen, A Kwong, L W Doyle, P B Marschik, C Einspieler, Jly Cheong
INTRODUCTION: Infants born extremely preterm (EP; <28 weeks' gestation) and/or with extremely low birth weight (ELBW; <1000 g birth weight) are at increased risk for adverse neurodevelopmental outcomes. However, it is challenging to predict those EP/ELBW infants destined to have long-term neurodevelopmental impairments in order to target early intervention to those in most need. The General Movements Assessment (GMA) in early infancy has high predictive validity for neurodevelopmental outcomes in preterm infants...
October 3, 2016: BMJ Open
Christa Einspieler, Michael Freilinger, Peter B Marschik
The dynamic course of Rett syndrome (RTT) is still said to begin with a period of apparently normal development although there is mounting evidence that individuals with RTT show behavioural peculiarities and abnormalities during their infancy. Their spontaneous general movements are abnormal from birth onwards. Normal cooing vocalisation and canonical babbling (if at all required) are interspersed with abnormalities such as proto-vowel and proto-consonant alternations produced on ingressive airstream, breathy voice characteristics, and pressed or high-pitched vocalisations...
September 2016: Wiener Medizinische Wochenschrift
Joy E Olsen, Nisha C Brown, Abbey L Eeles, Christa Einspieler, Katherine J Lee, Deanne K Thompson, Peter J Anderson, Jeanie L Y Cheong, Lex W Doyle, Alicia J Spittle
BACKGROUND: Neurodevelopmental assessments and brain magnetic resonance imaging (MRI) at term-equivalent age (TEA) predict developmental outcomes in preterm infants. However, the relationship between neurodevelopment prior to term and cerebral structure is currently unknown. AIMS: To examine the relationships between General Movements (GMs) assessed from birth to TEA and brain MRI at TEA in infants born <30weeks' gestation. STUDY DESIGN: Prospective cohort study...
October 2016: Early Human Development
Fei-Fei Zang, Hong Yang, Qian Han, Jia-Yan Cao, Iris Tomantschger, Magdalena Krieber, Wei Shi, Dan-Dan Luo, Mo Zhu, Christa Einspieler
BACKGROUND: Studies on motor performance and its early markers are rare in China, especially in very low birth weight (VLBW) infants. OBJECTIVE: Apart from the assessment of the inter-scorer agreement, we aimed to analyze to what extent the motor repertoire at 10 to 18weeks postterm was related to neonatal complications, and gross and fine motor performance at 12months after term. STUDY DESIGN: Exploratory prospective study. SUBJECTS: Seventy-four VLBW infants (58 males; mean gestational age=29weeks; mean birth weight=1252g)...
September 2016: Early Human Development
Nina Bastati, Andreas Wibmer, Dietmar Tamandl, Henrik Einspieler, Jacqueline C Hodge, Sarah Poetter-Lang, Susanne Rockenschaub, Gabriela A Berlakovich, Michael Trauner, Christian Herold, Ahmed Ba-Ssalamah
OBJECTIVE: The aim of this study was to evaluate the prognostic potential of a 3-parameter visual scoring (qualitative score [QS]) system for hepatobiliary phase gadoxetic acid-enhanced magnetic resonance imaging (MRI) in orthotopic liver transplant grafts. MATERIALS AND METHODS: This retrospective study of 128 patients was approved by our institutional review board. Two readers independently assigned 3 QSs to T1-weighted MRI scans, 20 minutes after the administration of gadoxetic acid (hepatobiliary phase), based upon the following: (1) liver parenchymal enhancement (EnQS, 0-2); (2) biliary contrast excretion (ExQS, 0-2); and (3) signal intensity of the portal vein relative to the liver parenchyma, that is, the portal vein sign (PVsQS, 0-2)...
May 11, 2016: Investigative Radiology
Christa Einspieler, Arend F Bos, Melissa E Libertus, Peter B Marschik
Apart from motor and behavioral dysfunctions, deficits in cognitive skills are among the well-documented sequelae of preterm birth. However, early identification of infants at risk for poor cognition is still a challenge, as no clear association between pathological findings based on neuroimaging scans and cognitive functions have been detected as yet. The Prechtl General Movement Assessment (GMA) has shown its merits for the evaluation of the integrity of the young nervous system. It is a reliable tool for identifying infants at risk for neuromotor deficits...
2016: Frontiers in Psychology
Christa Einspieler, Robert Peharz, Peter B Marschik
OBJECTIVES: To describe fidgety movements (FMs), i.e., the spontaneous movement pattern that typically occurs at 3-5 months after term age, and discuss its clinical relevance. SOURCES: A comprehensive literature search was performed using the following databases: MEDLINE/PubMed, CINAHL, The Cochrane Library, Science Direct, PsycINFO, and EMBASE. The search strategy included the MeSH terms and search strings ('fidgety movement*') OR [('general movement*') AND ('three month*') OR ('3 month*')], as well as studies published on the General Movements Trust website (www...
May 2016: Jornal de Pediatria
Colleen Peyton, Edward Yang, Masha Kocherginsky, Lars Adde, Toril Fjørtoft, Ragnhild Støen, Arend F Bos, Christa Einspieler, Michael D Schreiber, Michael E Msall
BACKGROUND: Cerebral Magnetic Resonance Imaging, the General Movement Assessment, and the Test of Infant Motor Performance are all tools that can predict neurodevelopmental outcome in preterm infants. However, how these tests relate to each other is unclear. AIMS: To examine the relationship between cerebral Magnetic Resonance Imaging measured at term age, and the General Movement Assessment and Test of Infant Motor Performance measured at 10-15 weeks post-term age...
April 2016: Early Human Development
Ingo Einspieler, Robert Tauber, Tobias Maurer, Markus Schwaiger, Matthias Eiber
Ga prostate-specific membrane antigen (PSMA)-HBED-CC PET/CT in a patient with a history of both prostate cancer (PC) and renal cell cancer (RCC) shows high PSMA expression in the residual right seminal vesicle suggestive of local recurrence of PC as well as suspected PSMA-positive mediastinal, retroperitoneal, and iliac lymph nodes. Regarding the latter, biopsy revealed lymph node metastases from RCC excluding PC metastases. This case exemplarily demonstrates that high PSMA expression in RCC metastases can potentially mimic PC metastases...
May 2016: Clinical Nuclear Medicine
Magdalena Krieber, Katrin D Bartl-Pokorny, Florian B Pokorny, Christa Einspieler, Andrea Langmann, Christof Körner, Terje Falck-Ytter, Peter B Marschik
Over the past decades, the relation between reading skills and eye movement behavior has been well documented in English-speaking cohorts. As English and German differ substantially with regard to orthographic complexity (i.e. grapheme-phoneme correspondence), we aimed to delineate specific characteristics of how reading speed and reading comprehension interact with eye movements in typically developing German-speaking (Austrian) adolescents. Eye movements of 22 participants (14 females; mean age = 13;6 years;months) were tracked while they were performing three tasks, namely silently reading words, texts, and pseudowords...
2016: PloS One
Thomas Pyka, Gregor Weirich, Ingo Einspieler, Tobias Maurer, Jörg Theisen, Georgios Hatzichristodoulou, Kristina Schwamborn, Markus Schwaiger, Matthias Eiber
UNLABELLED: In prostate cancer (PC) patients, the differentiation between lung metastases and lesions of different origin, for example, primary lung cancer, is a common clinical question. Herein, we investigated the use of Glu-NH-CO-NH-Lys(Ahx)-HBED-CC ((68)Ga-PSMA-HBED-CC) for this purpose. METHODS: PC patients (n = 1,889) undergoing (68)Ga-PSMA PET/CT or PET/MR scans were evaluated retrospectively for suggestive lung lesions. For up to 5 lesions per patient, location, CT diameter, CT morphology, and SUVmax were determined...
March 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Ingo Einspieler, Klaus Thürmel, Matthias Eiber
No abstract text is available yet for this article.
February 7, 2016: European Heart Journal
S Bölte, K D Bartl-Pokorny, U Jonsson, S Berggren, D Zhang, E Kostrzewa, T Falck-Ytter, C Einspieler, F B Pokorny, E J H Jones, H Roeyers, T Charman, P B Marschik
UNLABELLED: We reviewed original research papers that used quantifiable technology to detect early autism spectrum disorder (ASD) and identified 376 studies from 34 countries from 1965 to 2013. Publications have increased significantly since 2000, with most coming from the USA. Electroencephalogram, magnetic resonance imaging and eye tracking were the most frequently used technologies. CONCLUSION: The use of quantifiable technology to detect early ASD has increased in recent decades, but has had limited impact on early detection and treatment...
February 2016: Acta Paediatrica
Christa Einspieler, Peter B Marschik, Jasmin Pansy, Anna Scheuchenegger, Magdalena Krieber, Hong Yang, Maria K Kornacka, Edyta Rowinska, Marina Soloveichick, Arend F Bos
AIM: To explore the appropriateness of applying a detailed assessment of general movements and characterize the relationship between global and detailed assessment. METHOD: The analysis was based on 783 video recordings of 233 infants (154 males, 79 females) who had been videoed from 27 to 45 weeks postmenstrual age. Apart from assessing the global general movement categories (normal, poor repertoire, cramped-synchronized, or chaotic general movements), we scored the amplitude, speed, spatial range, proximal and distal rotations, onset and offset, tremulous and cramped components of the upper and lower extremities...
April 2016: Developmental Medicine and Child Neurology
Michele Zappella, Christa Einspieler, Katrin D Bartl-Pokorny, Magdalena Krieber, Mary Coleman, Sven Bölte, Peter B Marschik
BACKGROUND: Little is known about the first half year of life of individuals later diagnosed with autism spectrum disorders (ASD). There is even a complete lack of observations on the first 6 months of life of individuals with transient autistic behaviours who improved in their socio-communicative functions in the pre-school age. AIM: To compare early development of individuals with transient autistic behaviours and those later diagnosed with ASD. STUDY DESIGN: Exploratory study; retrospective home video analysis...
October 2015: Early Human Development
Gillian S Townend, Katrin D Bartl-Pokorny, Jeff Sigafoos, Leopold M G Curfs, Sven Bölte, Luise Poustka, Christa Einspieler, Peter B Marschik
This study compared early markers of social reciprocity in children with typical Rett syndrome (RTT) and in those with the preserved speech variant (PSV) of RTT. Retrospective video analysis of 10 toddlers with typical RTT and five with PSV investigated participants' orientation to their name being called between the ages of 5 and 24 months, prior to their diagnosis. From analysis of the recordings two distinct profiles were apparent. Although response rate was higher in girls with typical RTT than PSV at 5 to 8 months this noticeably reversed from 9 to 12 months onwards...
August 2015: Research in Developmental Disabilities
Ingo Einspieler, Klaus Thürmel, Thomas Pyka, Matthias Eiber, Sabine Wolfram, Philipp Moog, Christian Reeps, Markus Essler
PURPOSE: The aim of this study was to evaluate the feasibility of hybrid [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/MRI in patients with large vessel vasculitis (LVV) by comparing visual and quantitative parameters to that of PET/CT. Furthermore, the value of PET/MRI in disease activity and extent of LVV was assessed. METHODS: A total of 16 [(18)F]FDG PET/MRI and 12 [(18)F]-FDG PET/CT examinations were performed in 12 patients with LVV. MRI of the vessel wall by T1-weighted and T2-weighted sequences was used for anatomical localization of FDG uptake and identification of morphological changes associated with LVV...
June 2015: European Journal of Nuclear Medicine and Molecular Imaging
Christa Einspieler, Hong Yang, Katrin D Bartl-Pokorny, Xia Chi, Fei-Fei Zang, Peter B Marschik, Andrea Guzzetta, Fabrizio Ferrari, Arend F Bos, Giovanni Cioni
BACKGROUND: Infants with normal fidgety movements at 3 to 5 months after term are very likely to show neurologically normal development, while the absence of fidgety movements is an early marker for an adverse neurological outcome, mainly cerebral palsy (CP). The clinical significance of so-called sporadic fidgety movements (i.e., fidgety movements occur isolated in a few body parts and are of 1- to 3-second-duration) is not yet known. AIMS: Our objective was to determine whether infants who had developed CP and had sporadic fidgety movements have a better outcome than infants who did not have fidgety movements...
April 2015: Early Human Development
Peter B Marschik, Walter E Kaufmann, Sven Bölte, Jeff Sigafoos, Christa Einspieler
Research on acoustic communication and its underlying neurobiological substrates has led to new insights about the functioning of central pattern generators (CPGs). CPG-related atypicalities may point to brainstem irregularities rather than cortical malfunctions for early vocalizations/babbling. The "vocal pattern generator," together with other CPGs, seems to have great potential in disentangling neurodevelopmental disorders and potentially predict neurological development.
December 2014: Behavioral and Brain Sciences
Christa Einspieler, Peter B Marschik, Arend F Bos, Fabrizio Ferrari, Giovanni Cioni
No abstract text is available yet for this article.
November 2014: Developmental Psychobiology
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