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https://www.readbyqxmd.com/read/29687211/dual-threat-of-epstein-barr-virus-an-autopsy-case-report-of-hiv-positive-plasmablastic-lymphoma-complicating-ebv-associated-hemophagocytic-lymphohistiocytosis
#1
Yusuke Koizumi, Ken-Ichi Imadome, Yasunori Ota, Hitoshi Minamiguchi, Yoshinori Kodama, Dai Watanabe, Hiroshige Mikamo, Tomoko Uehira, Seiji Okada, Takuma Shirasaka
Epstein-Barr virus (EBV) reactivation causes serious diseases in immunocompromised hosts, such as acquired immunodeficiency syndrome (AIDS). We report on a case of plasmablastic lymphoma (PBL) with hemophagocytic lymphohistiocytosis (HLH).A-53-year-old Japanese man was diagnosed with PBL and AIDS. In addition to combined antiretroviral therapy, HyperCVAD (cyclophosphamide, doxorubicin, vincristine, prednisone)/high-dose methotrexate + cytarabine was initiated immediately. Partial remission was attained with chemotherapy...
April 23, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29685686/numerical-simulations-for-the-sources-apportionment-and-control-strategies-of-pm-2-5-over-pearl-river-delta-china-part-ii-vertical-distribution-and-emission-reduction-strategies
#2
Tao Deng, Yeqi Huang, Zhenning Li, Nan Wang, Shiqiang Wang, Yu Zou, Chanqin Yin, Shaojia Fan
The contribution of various emission sources to the vertical structure of the PM2.5 concentration and the modeling of emission reduction strategies are emphasized in this study. Analysis of vertical distribution of PM2.5 concentration in the planetary boundary layer (PBL) reveals that strong diurnal cycle exists during the pollution episodes, with heavier surface pollution in nocturnal periods. Contributions from transportation and agriculture are mainly restricted to the surface, while contributions from industry and power are distributed in a relatively higher layer...
April 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679112/post-treatment-positron-emission-tomography-computed-tomography-is-highly-predictive-of-outcome-in-plasmablastic-lymphoma
#3
Yassine Al Tabaa, Emmanuelle Tchernonog, Pierre Faurie, Anne Ségolène Cottereau, Hélène Monjanel, Antoine Bonnet, Steven Le Gouill, Emmanuel Gyan, Hervé Ghesquieres, Denis Mariano-Goulart, Guillaume Cartron
PURPOSE: Plasmablastic lymphoma (PBL) is a rare variant of diffuse large B cell lymphomas (DLBCL) clinically characterized by a poorer prognostic. Few clinical and imaging data are available and derived from pooled case reports and small series. The aim of the study was to evaluate the FDG avidity at baseline and the utility of 18-Fluorodeoxyglucose (FDG) positron-emission-tomography/computed-tomography (PET/CT) for staging and response assessment. METHODS: Patients with newly diagnosed PBL seen at Lymphoma Study Association centers during the period 2005-2015 were included if they underwent a PET/CT at staging and at the end of treatment (eotPET) and had received an anthracycline-based first line therapy...
April 20, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29670415/matching-medical-student-achievement-to-learning-objectives-and-outcomes-a-paradigm-shift-for-an-implemented-teaching-module
#4
Ihab Shafek Atta, Fahd Nasser AlQahtani
Introduction: Low student achievement in a basic imaging module was the impetus for an assessment of the module. Methods: A valid, reliable, and structured Likert scale was designed to measure the degree of student satisfaction with the domains of the module, including learning objectives (LO), teaching strategy and tools (TT), assessment tools (AT), and allotted credit hours (CH). Further analysis was conducted of student dissatisfaction to determine the subdomain in which module improvement was to be implemented...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29670414/integration-of-leadership-training-into-a-problem-case-based-learning-program-for-first-and-second-year-medical-students
#5
Samara B Ginzburg, Susan Deutsch, Jaclyn Bellissimo, David E Elkowitz, Joel Nh Stern, Robert Lucito
Purpose: The evolution of health care systems in response to societal and financial pressures has changed care delivery models, which presents new challenges for physicians. Leadership training is increasingly being recognized as an essential component of medical education training to prepare physicians to meet these needs. Unfortunately, most medical schools do not include leadership training. It has been suggested that a longitudinal and integrated approach to leadership training should be sought...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29668075/a-comparison-of-debate-and-role-play-in-enhancing-critical-thinking-and-communication-skills-of-medical-students-during-problem-based-learning
#6
Rabia Latif, Sadaf Mumtaz, Rafia Mumtaz, Aamir Hussain
Debate and role play for learning critical thinking and communication skills are being increasingly used in various undergraduate medical schools worldwide. We aim to compare students' views about effectiveness of two teaching strategies; debate and role play to exercise critical thinking and communication skills during problem-based learning (PBL). This is a comparative, cross-sectional, and questionnaire-based study. Our subjects were second year undergraduate female medical students enrolled in Imam Abdulrahman Bin Faisal University (IAU), College of Medicine from September 2014-2016, divided into 10 small PBL groups (10-13 students/group/year)...
April 18, 2018: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29666505/new-positive-feedback-mechanism-between-boundary-layer-meteorology-and-secondary-aerosol-formation-during-severe-haze-events
#7
Quan Liu, Xingcan Jia, Jiannong Quan, Jiayun Li, Xia Li, Yongxue Wu, Dan Chen, Zifa Wang, Yangang Liu
Severe haze events during which particulate matter (PM) increases quickly from tens to hundreds of microgram per cubic meter in 1-2 days frequently occur in China. Although it has been known that PM is influenced by complex interplays among emissions, meteorology, and physical and chemical processes, specific mechanisms remain elusive. Here, a new positive feedback mechanism between planetary boundary layer (PBL), relative humidity (RH), and secondary PM (SPM) formation is proposed based on a comprehensive field experiment and model simulation...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29643904/assessment-of-collaborative-problem-solving-skills-in-undergraduate-medical-students-at-ziauddin-college-of-medicine-karachi
#8
Arsalan Manzoor Mughal, Sirajul Haque Shaikh
Objective: Collaborative Problem Solving Empirical Progressions from the Assessment and Teaching of 21st Century Skills (ATC21S) framework were used to determine the level of collaborative problem solving skills (CPS) in first, second and third year MBBS students at Ziauddin College of Medicine during Problem-Based Learning (PBL) sessions. Variations based on gender and roles were studied. Methods: It is an analytical comparative cross-sectional study in which seven PBL groups were selected per year by non-probability convenient sampling...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29629391/medical-students-perceptions-of-small-group-teaching-effectiveness-in-hybrid-curriculum
#9
Pradeep Kumar Sahu, Shivananda Nayak, Vincent Rodrigues
OBJECTIVES: The objective of this study was designed to investigate medical students' perceptions of small group teaching effectiveness in a hybrid curriculum. MATERIALS AND METHODS: A cross-sectional, descriptive survey was conducted at the School of Medicine, The University of the West Indies, St. Augustine where we collected the data from 195 undergraduate students. A self-administered questionnaire consisting of 25 items was used to measure students' perception on the effectiveness of problem-based learning (PBL) with regard to learning experience, teamwork, confidence, communication skills, and role of the tutor...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29568379/leukocyte-telomere-length-throughout-the-continuum-of-colorectal-carcinogenesis
#10
Cornelia Zöchmeister, Stefanie Brezina, Philipp Hofer, Andreas Baierl, Michael M Bergmann, Thomas Bachleitner-Hofmann, Judith Karner-Hanusch, Anton Stift, Armin Gerger, Gernot Leeb, Karl Mach, Sivaramakrishna Rachakonda, Rajiv Kumar, Andrea Gsur
Considering the high prevalence of colorectal cancer (CRC) and relatively high mortality there is strong interest in identification of clinically relevant biomarkers. Telomere shortening is supposed to contribute to genomic instability and crucially involved in process of carcinogenesis. Peripheral blood leukocyte (PBL) telomere length was previously investigated in several studies as potential biomarker for CRC but with controversial results. This prompted us to investigate relative PBL telomere length in association with different histological findings throughout the continuum of colorectal carcinogenesis in order to reflect the whole spectrum of putative CRC development in a large study involving 2011 individuals...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29545645/ligand-triggered-de-repression-of-arabidopsis-heterotrimeric-g-proteins-coupled-to-immune-receptor-kinases
#11
Xiangxiu Liang, Miaomiao Ma, Zhaoyang Zhou, Jinlong Wang, Xinru Yang, Shaofei Rao, Guozhi Bi, Lin Li, Xiaojuan Zhang, Jijie Chai, She Chen, Jian-Min Zhou
Arabidopsis heterotrimeric G proteins regulate diverse processes by coupling to single-transmembrane receptors. One such receptor is the FLS2 receptor kinase, which perceives bacterial flagellin epitope flg22 to activate immunity through a class of cytoplasmic kinases called BIK1/PBLs. Unlike animal and fungal heterotrimeric G proteins that are activated by a ligand-induced guanine nucleotide exchange activity of seven-transmembrane G protein-coupled receptors (GPCRs), plant heterotrimeric G proteins are self-activating...
March 15, 2018: Cell Research
https://www.readbyqxmd.com/read/29543568/impact-of-a-problem-based-learning-pbl-health-literacy-program-on-immigrant-women-s-health-literacy-health-empowerment-navigation-efficacy-and-health-care-utilization
#12
Tzu-I Tsai, Shoou-Yih D Lee, Wen-Ry Yu
We evaluated the effectiveness of a problem-based learning (PBL) health literacy program aimed to improve health literacy, health empowerment, navigation efficacy, and health care utilization among immigrant women in Taiwan. We employed a quasi-experimental design that included surveys at the baseline, immediately after the intervention, and 6 months after the intervention. The intervention group participated in a 10-session PBL health literacy program and the comparison group did not. Results showed that 6 months after the intervention, the intervention group had significantly fewer ER visits and hospitalizations than the comparison group...
March 15, 2018: Journal of Health Communication
https://www.readbyqxmd.com/read/29531882/creating-a-student-centered-learning-environment-implementation-of-problem-based-learning-to-teach-microbiology-to-undergraduate-medical-students
#13
Venkataramana Kandi, Parimala Reddy Basireddy
Introduction Medical education involves training necessary to become a physician or a surgeon. This includes various levels of training like undergraduate, internship, and postgraduate training. Medical education can be quite complex, since it involves training in pre-clinical subjects (anatomy, physiology, biochemistry), the para-clinical subjects (microbiology, pathology, pharmacology, and forensic medicine), and a discrete group of clinical subjects that include general medicine, surgery, obstetrics and gynaecology, ear, nose and throat specialization, paediatrics, cardiology, pulmonology, dermatology, ophthalmology, and orthopaedics, and many other clinical specializations and super specialities (cardio-thoracic surgery, neurosurgery, etc...
January 5, 2018: Curēus
https://www.readbyqxmd.com/read/29525600/an-autologous-tumor-vaccine-for-cll
#14
Fang Zhu, Ismat Khatri, David Spaner, Reginald M Gorczynski
Chronic Lymphocytic Leukemia B cells (CLL) are malignant cells which retain at least some functions of normal B cells. Paramount amongst the latter is that when such cells are appropriately stimulated, they are able to present antigens, including any potential tumor antigens, making them excellent choices as a candidate tumor vaccine. We show that following stimulation of CLL cells with Phorbol myristic acetate, IL-2, the TLR7 agonist imiquimod (P2I) and ionomycin (P2Iio), markedly increased expression of CD54 and CD83 was seen, indicative of B cell activation and a transition to antigen-presenting cells...
March 2, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29515274/incorporating-problem-based-learning-into-medical-curriculum-an-experience-from-a-medical-college-in-mangalore
#15
Nithin Kumar, Tanuj Kanchan, Bhaskaran Unnikrishnan, Rekha Thapar, Prasanna Mithra, Vaman Kulkarni, Ramesh Holla, Darshan Bhagwan, Yeshwanter Radhakrishnan
BACKGROUND: The Medical Council of India (MCI) has envisioned a change in the undergraduate medical curriculum by encouraging integrated teaching and Problem Based Learning (PBL). METHODS: In this cross-sectional study 110 medical teachers of Kasturba Medical College, Mangalore were assessed regarding their perception on PBL. Independent t -test was applied to find out the difference in the mean perception scores regarding PBL among the teachers in pre/para-clinical and clinical departments and P < 0...
September 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29510609/an-analysis-of-medical-students-reflective-essays-in-problem-based-learning
#16
Jihyun Si
PURPOSE: This study aimed to explore students' learning experience in problem-based learning (PBL) particularly in terms of what they learned and how they learned in one Korean medical school by analyzing their reflective essays with qualitative research methods. METHODS: This study included 44 first-year medical students. They took three consecutive PBL courses and wrote reflective essays 3 times anonymously on the last day of each course. Their reflective essays were analyzed using an inductive content analysis method...
March 2018: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/29503203/altered-peptide-ligands-impact-the-diversity-of-polyfunctional-phenotypes-in-t-cell-receptor-gene-modified-t-cells
#17
Timothy T Spear, Yuan Wang, Thomas W Smith, Patricia E Simms, Elizabeth Garrett-Mayer, Lance M Hellman, Brian M Baker, Michael I Nishimura
The use of T cell receptor (TCR) gene-modified T cells in adoptive cell transfer has had promising clinical success, but often, simple preclinical evaluation does not necessarily accurately predict treatment efficacy or safety. Preclinical studies generally evaluate one or a limited number of type 1 cytokines to assess antigen recognition. However, recent studies have implicated other "typed" T cells in effective anti-tumor/viral immunity, and limited functional evaluations may underestimate cross-reactivity...
February 2, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29497698/a-model-of-interprofessional-problem-based-learning-for-medical-and-nursing-students-implementation-evaluation-and-implications-for-future-implementation
#18
Adina Dreier-Wolfgramm, Sabine Homeyer, Roman F Oppermann, Wolfgang Hoffmann
Objective: In Germany there is little evidence of interprofessional problem-based learning (PBL) to date. For this reason a corresponding course for medical and nursing students was implemented. The goal was to analyse the feasibility and usefulness from the point of view of the students. Method: For the purposes of evaluation a quantitative observational study was conducted with a pre-course survey, a teaching evaluation and a post-course survey. The pre- and post-course surveys took place before the commencement of and after the conclusion of learning...
2018: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/29489669/effects-of-problem-based-learning-in-chinese-radiology-education-a-systematic-review-and-meta-analysis
#19
Song Zhang, Jiancheng Xu, Hongwei Wang, Dong Zhang, Qichuan Zhang, Liguang Zou
BACKGROUND: In recent years, the problem-based learning (PBL) teaching method has been extensively applied as an experimental educational method in Chinese radiology education. However, the results of individual studies were inconsistent and inconclusive. A meta-analysis was performed to evaluate the effects of PBL on radiology education in China. METHODS: Databases of Chinese and English languages were searched from inception up to November 2017. The standard mean difference (SMD) with its 95% confidence interval (95% CI) was used to determine the over effects of PBL compared with the traditional teaching method...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29475930/primary-gastric-ebv-positive-diffuse-large-b-cell-lymphoma-dlbcl-of-the-elderly-with-plasmablastic-differentiation
#20
Ming Hu, Jose Trevino, Lijun Yang, Dengfeng Cao, Xiuli Liu, Jinping Lai
Epstein-Barr virus (EBV)-positive diffuse large B cell lymphoma (DLBCL) of the elderly is a rare subtype of B-cell neoplasms. Primary gastric EBV-positive DLBCL of the elderly with partial plasmablastic phenotype is extremely rare. Differentiation of EBV-positive DLBCL of the elderly with partial plasmablastic phenotype from true plasmablastic lymphoma (PBL) is difficult and very important from the therapeutic and prognostic point of view. Here we report a case of a 59-year-old man with upper gastrointestinal bleeding...
March 2018: In Vivo
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