keyword
MENU ▼
Read by QxMD icon Read
search

"PBL"

keyword
https://www.readbyqxmd.com/read/29233928/integrated-molecular-characterization-of-the-lethal-pediatric-cancer-pancreatoblastoma
#1
Tomoya Isobe, Masafumi Seki, Kenichi Yoshida, Masahiro Sekiguchi, Yusuke Shiozawa, Yuichi Shiraishi, Shunsuke Kimura, Misa Yoshida, Yoshikage Inoue, Akira Yokoyama, Nobuyuki Kakiuchi, Hiromichi Suzuki, Keisuke Kataoka, Yusuke Sato, Tomoko Kawai, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Motohiro Kato, Akihiro Iguchi, Asahito Hama, Tomoaki Taguchi, Masaharu Akiyama, Junya Fujimura, Akiko Inoue, Tsuyoshi Ito, Takao Deguchi, Chikako Kiyotani, Tomoko Iehara, Hajime Hosoi, Akira Oka, Masashi Sanada, Yukichi Tanaka, Kenichiro Hata, Satoru Miyano, Seishi Ogawa, Junko Takita
Pancreatoblastoma (PBL) is a rare pediatric pancreatic malignancy for which the molecular pathogenesis is not understood. In this study, we report the findings of an integrated multi-omics study of whole exome and RNA sequencing as well as genome-wide copy number and methylation analyses of 10 PBL cases. The PBL genome was characterized by a high frequency of aberrant activation of the Wnt signaling pathway, either via somatic mutations of CTNNB1 (90%) and copy-neutral loss of heterozygosity (CN-LOH) of APC (10%)...
December 12, 2017: Cancer Research
https://www.readbyqxmd.com/read/29233448/introducing-problem-based-learning-into-a-canadian-accredited-middle-eastern-educational-setting
#2
Ziad G Nasr, Kyle John Wilby
BACKGROUND AND PURPOSE: Adaption of active learning strategies into new cultures and contexts requires careful consideration to maximize effectiveness and meet intended objectives. The aim of this paper was to describe the adaption and implementation of problem-based learning (PBL) within a pharmacy curriculum in a Middle Eastern context. EDUCATIONAL ACTIVITY AND SETTING: PBL was implemented into the curriculum at Qatar University in 2014 and expanded in subsequent years to include differing courses and contexts...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29221459/team-based-learning-tbl-in-the-medical-curriculum-better-than-pbl
#3
Annette Burgess, Jane Bleasel, Inam Haq, Chris Roberts, Roger Garsia, Tomas Robertson, Craig Mellis
BACKGROUND: Internationally, medical schools have long used a variety of approaches to develop hybrid Problem based learning (PBL) curricula. However, Team-based learning (TBL), has gained recent popularity in medical education. TBL maintains the advantages of small group teaching and learning, but in contrast to Problem-based learning (PBL), does not require large numbers of tutors. In 2016, TBL was introduced to Year 1 of the Sydney Medical Program (SMP).This study sought to compare students' perceptions of using TBL in place of PBL...
December 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29207458/implementation-of-problem-based-learning-in-medical-education-in-korea
#4
Sanghee Yeo, Bong Hyun Chang
PURPOSE: This study aims to identify how problem-based learning (PBL) has been implemented in Korean medical education, and how it is evaluated by each medical school. METHODS: For this study, a total of 40 medical schools in Korea were surveyed via e-mail. The survey tool was a questionnaire consisting of 22 questions which was developed independently by the researchers. RESULTS: Of the 40 medical schools, 35 schools were implementing PBL programs in their medical curriculum, while five were found not currently to be running the program...
December 2017: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/29187222/unusual-presentation-of-plasmablastic-lymphoma-involving-ovarian-mature-cystic-teratoma-a-case-report
#5
Ita Hadžisejdić, Emina Babarović, Luka Vranić, Antica Duletić Načinović, Ksenija Lučin, Maja Krašević, Nives Jonjić
BACKGROUND: Plasmablastic lymphoma (PBL) is relatively new clinical entity described as a distinct subtype of diffuse large B-cell lymphoma (DLBCL). It is characterized by its aggressive nature and proliferation of large neoplastic cells resembling immunoblasts including cells with more obvious plasmacytic differentiation. In this case report, we describe an unexpected finding of PBL associated with a mature cystic teratoma of the ovary in a young immune competent woman. CASE PRESENTATION: A 19-year old woman was admitted to the hospital with generalized lymphadenopathy, a pelvic tumor mass measuring 35 × 30 cm and a 4 cm lump in her right breast...
November 29, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/29184209/a-craniofacial-specific-monosynaptic-circuit-enables-heightened-affective-pain
#6
Erica Rodriguez, Katsuyasu Sakurai, Jennie Xu, Yong Chen, Koji Toda, Shengli Zhao, Bao-Xia Han, David Ryu, Henry Yin, Wolfgang Liedtke, Fan Wang
Humans often rank craniofacial pain as more severe than body pain. Evidence suggests that a stimulus of the same intensity induces stronger pain in the face than in the body. However, the underlying neural circuitry for the differential processing of facial versus bodily pain remains unknown. Interestingly, the lateral parabrachial nucleus (PBL), a critical node in the affective pain circuit, is activated more strongly by noxious stimulation of the face than of the hindpaw. Using a novel activity-dependent technology called CANE developed in our laboratory, we identified and selectively labeled noxious-stimulus-activated PBL neurons and performed comprehensive anatomical input-output mapping...
December 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29169067/the-role-of-personal-resilience-and-personality-traits-of-healthcare-students-on-their-attitudes-towards-interprofessional-collaboration
#7
Michal Avrech Bar, Michal Katz Leurer, Sigalit Warshawski, Michal Itzhaki
BACKGROUND: Interprofessional collaboration (IPC) improves communication between healthcare workers and healthcare delivery. Interprofessional education (IPE) is essential in preparing healthcare students for cooperating with other healthcare disciplines in a real work setting. Although higher education settings have a responsibility to provide collaborative healthcare practice to students, IPE has not yet been prompted worldwide as a formal division in health professional education and in Israel IPE among health professions students is scarce...
November 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29162061/medical-student-attitudes-and-educational-interventions-to-prevent-neurophobia-a-longitudinal-study
#8
Lisa Shiels, Pratish Majmundar, Aleksander Zywot, John Sobotka, Christine S M Lau, Tuula O Jalonen
BACKGROUND: With an aging American population, the burden of neurologic disease is intensifying and the decline in neurology residents and practicing neurologists is leaving these patients helpless and unable to find care. 'Neurophobia', a chronic illness that begins early in medical school, has been identified as a cause for the low number of neurology residents. METHODS: A longitudinal study surveyed medical students at the beginning of their first year (M1) and then again at the beginning of their second year (M2)...
November 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29150676/severe-pollution-in-china-amplified-by-atmospheric-moisture
#9
Xuexi Tie, Ru-Jin Huang, Junji Cao, Qiang Zhang, Yafang Cheng, Hang Su, Di Chang, Ulrich Pöschl, Thorsten Hoffmann, Uli Dusek, Guohui Li, Douglas R Worsnop, Colin D O'Dowd
In recent years, severe haze events often occurred in China, causing serious environmental problems. The mechanisms responsible for the haze formation, however, are still not well understood, hindering the forecast and mitigation of haze pollution. Our study of the 2012-13 winter haze events in Beijing shows that atmospheric water vapour plays a critical role in enhancing the heavy haze events. Under weak solar radiation and stagnant moist meteorological conditions in winter, air pollutants and water vapour accumulate in a shallow planetary boundary layer (PBL)...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29104625/high-expression-of-long-chain-acyl-coenzyme-a-synthetase-1-in-peripheral-blood-may-be-a-molecular-marker-for-assessing-the-risk-of-acute-myocardial-infarction
#10
Liping Yang, Yushuang Yang, Daoyuan Si, Kaiyao Shi, Dongna Liu, Heyu Meng, Fanbo Meng
The current study aimed to investigate whether the increased expression of long chain acyl-coenzymeA synthetase 1 (ACSL1) in peripheral blood leukocytes (PBL) may be a molecular marker for the genetic evaluation of acute myocardial infarction (AMI). The mechanism of action of ACSL1 in the pathogenesis of AMI was also investigated. A total of 75 patients with AMI and 70 individuals without coronary heart disease were selected to participate in the present study. The demographic and clinical information of the enrolled subjects was recorded...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29101395/a-teleost-cd46-is-involved-in-the-regulation-of-complement-activation-and-pathogen-infection
#11
Mo-Fei Li, Zhi-Hai Sui, Li Sun
In mammals, CD46 is involved in the inactivation of complement by factor I (FI). In teleost, study on the function of CD46 is very limited. In this study, we examined the immunological property of a CD46 molecule (CsCD46) from tongue sole, a teleost species with important economic value. We found that recombinant CsCD46 (rCsCD46) interacted with FI and inhibited complement activation in an FI-dependent manner. rCsCD46 also interacted with bacterial pathogens via a different mechanism to that responsible for the FI interaction, involving different rCsCD46 sites...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29096591/comparison-between-flipped-classroom-and-lecture-based-classroom-in-ophthalmology-clerkship
#12
Fen Tang, Chuan Chen, Yi Zhu, Chengguo Zuo, Yimin Zhong, Nan Wang, Lijun Zhou, Yuxian Zou, Dan Liang
BACKGROUND: In recent years, the flipped classroom method of teaching has received much attention in health sciences education. However, the application of flipped classrooms in ophthalmology education has not been well investigated. OBJECTIVE: The goal of this study was to investigate the effectiveness and acceptability of the flipped classroom approach to teaching ophthalmology at the clerkship level. DESIGN: Ninety-five fourth year medical students in an ophthalmology clerkship were randomly divided into two groups...
2017: Medical Education Online
https://www.readbyqxmd.com/read/29092557/articulatory-characteristics-of-preboundary-lengthening-in-interaction-with-prominence-on-tri-syllabic-words-in-american-english
#13
Sahyang Kim, Jiyoung Jang, Taehong Cho
This study investigated articulation of preboundary lengthening (PBL) in tri-syllabic pseudo words (bábaba, babába, bababá) in American English. Results from 10 speakers showed that PBL was modulated by the degree of prominence, i.e., the less prominent, the more PBL. PBL was attracted to the penultimate stressed syllable but only when the word received no pitch accent whereas the antepenultimate syllable showed no PBL. Kinematically, PBL was accompanied by a larger movement along with an increase in peak velocity, showing a kind of boundary-related articulatory strengthening, although there was some evidence of temporal expansion possibly due to lowered stiffness...
October 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29092002/pstab-prediction-of-stable-mutants-unfolding-curves-stability-maps-and-protein-electrostatic-frustration
#14
Soundhararajan Gopi, Devanshu Devanshu, Praveen Krishna, Athi N Naganathan
Summary: We present a web-server for rapid prediction of changes in protein stabilities over a range of temperatures and experimental conditions upon single- or multiple-point substitutions of charged residues. Potential mutants are identified by a charge-shuffling procedure while the stability changes (i.e. an unfolding curve) are predicted employing an ensemble-based statistical-mechanical model. We expect this server to be a simple yet detailed tool for engineering stabilities, identifying electrostatically frustrated residues, generating local stability maps and in constructing fitness landscapes...
October 28, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29090101/plasmablastic-lymphoma-case-report-of-prolonged-survival-of-an-advanced-human-immunodeficiency-patient-and-literature-review
#15
Hind Rafei, Ehab El-Bahesh, Antoine Finianos, Min-Ling L Liu, Geraldine P Schechter
Clinical Practice Points. Plasmablastic lymphoma (PBL) is a rare and highly aggressive variant of diffuse large B cell lymphoma with median survival of advanced stage patients varying between 6 and 15 months in previous reports. We report here a human immunodeficiency virus-infected patient surviving over 12 years following treatment for advanced PBL with EPOCH chemotherapy and intrathecal therapy. This case highlights the potential for improved survival in PBL with intensive chemotherapy. Further, literature review suggests promising prospects utilizing novel targeted therapies to increase the rate of prolonged responses...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29066482/the-effect-of-metformin-on-the-expression-of-gpr109a-nf-%C3%AE%C2%BAb-and-il-1%C3%AE-in-peripheral-blood-leukocytes-from-patients-with-type-2-diabetes-mellitus
#16
Xiaoling Xu, Shaoda Lin, Yongsong Chen, Xitao Li, Shuhua Ma, Yucai Fu, Chiju Wei, Chang Wang, Wencan Xu
OBJECTIVES: Type 2 Diabetes Mellitus (T2DM), which often accompanies dyslipidemia, is considered an inflammatory disease. GPR109A, as a niacin receptor, is up-regulated under high glucose concentration. Activation of GPR109A reduces GSIS and exerts anti-inflammatory effects by regulating NF-κB/IL-1β signaling. Metformin improves hyperglycemia, increases insulin sensitivity and attenuates the activation of the NF-κB pathway in T2DM. We aimed to examine whether metformin plays beneficial effects in T2DM by regulating the GPR109A signaling...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29066398/characterization-of-a-teleost-membrane-associated-protein-that-is-involved-in-the-regulation-of-complement-activation-and-bacterial-infection
#17
Mo-Fei Li, Li Sun
In mammals, membrane-associated complement regulatory proteins (MCRP) can protect host cells from the damaging of the activated complement. In teleost, few studies on the function of MCRP have been documented. In the present report, we identified a MCRP (named CsMCRP) from the teleost fish tongue sole Cynoglossus semilaevis and examined its immune function. CsMCRP shares moderate sequence identities with fish DAF-like molecules. CsMCRP was predicted to be a transmembrane protein with three short consensus repeats located in the extracellular region...
October 21, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29059802/problem-based-learning-for-engineering
#18
Dinesh Kumar, Pj Radcliffe
the role of Problem Based Learning (PBL) is relative clear in domains such as medicine but its efficacy in engineering is as yet less certain. To clarify the role of PBL in engineering, a 3 day workshop was conducted for senior Brazilian engineering academics where they were given the theory and then an immersive PBL experience. One major purpose for running this workshop was for them to identify suitable courses where PBL could be considered. During this workshop, they were split in teams and given a diverse range of problems...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29056610/problem-based-peer-to-peer-global-mental-health-e-learning-between-the-uk-and-somaliland-a-pilot-study
#19
Roberta Murphy, Elliot Clissold, Roxanne C Keynejad
BACKGROUND: WHO's mental health gap action programme intervention guide (mhGAP-IG) is an evidence-based tool aimed at front-line health workers in low-income and middle-income countries (LMICs). Its potential to improve global mental health education, especially through digital technologies, has been little studied. Problem-based learning (PBL) is usually conducted face-to-face, but its remote application could facilitate cross-cultural education. OBJECTIVE: To evaluate PBL, applied to peer-to-peer global mental health e-learning (Aqoon), using mhGAP-IG...
October 22, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29052312/bleomycin-induced-chromosomal-damage-and-shortening-of-telomeres-in-peripheral-blood-lymphocytes-of-incident-cancer-patients
#20
Michal Kroupa, Zdenka Polivkova, Sivaramakrishna Rachakonda, Michaela Schneiderova, Sona Vodenkova, Tomas Buchler, Katerina Jiraskova, Marketa Urbanova, Ludmila Vodickova, Kari Hemminki, Rajiv Kumar, Pavel Vodicka
Disruption of genomic integrity due to deficient DNA repair capacity and telomere shortening constitute hallmarks of malignant diseases. Incomplete or deficient repair of DNA double-strand breaks (DSB) is manifested by chromosomal aberrations (CAs) and their frequency reflects inter-individual differences of response to exposure to mutagenic compounds. In this study, we investigated chromosomal integrity in peripheral blood lymphocytes (PBL) from newly diagnosed cancer patients, including 47 breast (BC) and 44 colorectal cancer (CRC) patients and 90 matched healthy controls...
October 20, 2017: Genes, Chromosomes & Cancer
keyword
keyword
58415
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"