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https://www.readbyqxmd.com/read/28078685/peer-assessment-of-professional-behaviours-in-problem-based-learning-groups
#1
Chris Roberts, Christine Jorm, Stacey Gentilcore, Jim Crossley
CONTEXT: Peer assessment of professional behaviour within problem-based learning (PBL) groups can support learning and provide opportunities to identify and remediate problem behaviours. OBJECTIVES: We investigated whether a peer assessment of learning behaviours in PBL is sufficiently valid to support decision making about student professional behaviours. METHODS: Data were available for two cohorts of students, in which each student was rated by all of their PBL group peers using a modified version of a previously validated scale...
January 12, 2017: Medical Education
https://www.readbyqxmd.com/read/28066900/boosting-of-post-exposure-human-t-and-b-cell-recall-responses-in-vivo-by-burkholderia-pseudomallei-related-proteins
#2
Arnone Nithichanon, Louise J Gourlay, Gregory J Bancroft, Manabu Ato, Yoshimasa Takahashi, Ganjana Lertmemongkolchai
Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and Northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been exposed to the bacteria and have developed some immunity, which may have helped prevent disease. Here, we used a humanized mouse model (hu-PBL-SCID), reconstituted with human peripheral blood mononuclear cells (PBMCs) from seropositive donors, to illustrate the potential of three known antigens (FliC, OmpA and N-PilO2) for boosting both T- and B-cell immune responses...
January 9, 2017: Immunology
https://www.readbyqxmd.com/read/28061800/does-a-pbl-based-medical-curriculum-predispose-training-in-specific-career-paths-a-systematic-review-of-the-literature
#3
Jordan Tsigarides, Laura R Wingfield, Myutan Kulendran
BACKGROUND: North American medical schools have used problem-based learning (PBL) structured medical education for more than 60 years. However, it has only recently been introduced in other medical schools outside of North America. Since its inception, there has been the debate on whether the PBL learning process predisposes students to select certain career paths. OBJECTIVES: To review available evidence to determine the predisposition of specific career paths when undertaking a PBL-based medical curriculum...
January 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28061777/whatsapp-messenger-as-a-tool-to-supplement-medical-education-for-medical-students-on-clinical-attachment
#4
Lewis Raiman, Richard Antbring, Asad Mahmood
BACKGROUND: Instant messaging applications have the potential to improve and facilitate communication between hospital doctors and students, hence generating and improving learning opportunities. This study aims to demonstrate the feasibility and acceptability of instant messaging communication to supplement medical education for medical students whilst on clinical attachment. METHODS: A total of 6 WhatsApp Messenger (WhatsApp Inc.) groups were created for medical students on clinical attachment...
January 6, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28056862/association-between-telomere-length-and-the-risk-of-colorectal-cancer-a-meta-analysis-of-observational-studies
#5
Cho Naing, Kyan Aung, Pei Kuan Lai, Joon Wah Mak
BACKGROUND: Human chromosomes are capped and stabilized by telomeres. Telomere length regulates a 'cellular mitotic clock' that defines the number of cell divisions and hence, cellular life span. This study aimed to synthesize the evidence on the association between peripheral blood leucocytes (PBL) telomere length and the risk of colorectal cancer (CRC). METHODS: We searched relevant studies in electronic databases. When two or more observational studies reported the same outcome measures, we performed pooled analysis...
January 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28050411/faculty-perception-towards-a-hybrid-problem-based-learning-methodology
#6
Nitin Joseph, Animesh Jain, Shashidhar M Kotian
This sequential quantitative and qualitative study was done to assess the perception of faculties towards a hybrid Problem Based Learning (PBL) methodology. To begin with, all faculty members of the department featured in a round of PBL facilitation. Later in phase I, their perception was assessed using a validated self-administered questionnaire. In phase II, personalized interview was conducted with each faculty. Finally phase (III) involved a focus group discussion on issues identified in previous phases...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049679/dental-students-perceptions-of-learning-value-in-pbl-groups-with-medical-and-dental-students-together-versus-dental-students-alone
#7
Maryam Amin, Rosslynn Zulla, Gisele Gaudet-Amigo, Steven Patterson, Natalie Murphy, Shelley Ross
At a dental school in Canada, problem-based learning (PBL) sessions were restructured from an integrated dental-medical model to a separate dental model, resulting in three groups of students available for study: those who had participated in the two-year dental and medical combined, the one-year dental and medical combined, the one-year dental alone, and the two-year dental alone. The aim of this qualitative study was to examine the extent to which the PBL structure affected the dental students' perceptions of the learning value of PBL in the different models...
January 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28032051/problem-based-learning-dental-student-s-perception-of-their-education-environments-at-qassim-university
#8
Shahad S Alkhuwaiter, Roqayah I Aljuailan, Saeed M Banabilh
AIMS: The objectives of this study were to assess perceptions of the Saudi dental students of the problem-based learning (PBL) curriculum and to compare their perceptions among different sex and academic years. SUBJECTS AND METHODS: Data was collected through a questionnaire-based survey at Qassim College of dentistry. The questionnaire consisted of 19 questions regarding the perception of PBL curriculum and was distributed to 240 students. The chi-square test was used for statistical analysis of the data...
November 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28031174/clinical-characteristics-and-prognostic-factors-of-plasmablastic-lymphoma-patients-analysis-of-135-patients-from-the-lysa-group
#9
E Tchernonog, P Faurie, P Coppo, H Monjanel, A Bonnet, M Algarte Génin, M Mercier, J Dupuis, F Bijou, C Herbaux, A Delmer, B Fabiani, C Besson, S Le Gouill, E Gyan, C Laurent, H Ghesquieres, G Cartron
BACKGROUND: Plasmablastic lymphoma (PBL), initially described in 1997 in the oral cavity of HIV positive patients, is now recognized as a distinct aggressive and rare entity of diffuse large B-cells lymphoma (DLBCL) by the WHO (World Health Organization) classification. Since the original description, others cases have been reported. However, these are largely derived from case reports or small series limiting any definitive conclusions on clinical characteristics and outcome. PATIENTS AND METHODS: The clinical, biological, pathological features and outcome of a cohort including 135 patients with PBL, from LYSA centers in France and Belgium, were reported and analyzed...
December 28, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28024753/local-and-regional-contributions-to-fine-particulate-matter-in-beijing-during-heavy-haze-episodes
#10
Yangjun Wang, Shengwei Bao, Shuxiao Wang, Yongtao Hu, Xiang Shi, Jiandong Wang, Bin Zhao, Jingkun Jiang, Mei Zheng, Minghong Wu, Armistead G Russell, Yuhang Wang, Jiming Hao
In order to alleviate extreme haze pollution, understanding the origin of fine particulate matter (PM2.5) is crucial. In this study, we applied Particulate Matter Source Apportionment Technology (PSAT) in CAMx (Comprehensive Air Quality Model with Extensions) to quantify the impacts of emissions from different regions on PM2.5 concentrations in Beijing for haze episodes during January 6-23, 2013. Emission inventory was developed by Tsinghua University. Evolution of local and Regional contributions during local and non-local dominated haze episodes were discussed, separately...
December 23, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28011983/refractory-plasmablastic-lymphoma-a-review-of-treatment-options-beyond-standard-therapy
#11
REVIEW
Dominik Pretscher, Alexander Kalisch, Martin Wilhelm, Josef Birkmann
Plasmablastic lymphoma (PBL) is a rare distinct subtype of aggressive diffuse large B-cell lymphoma and a notoriously hard to treat entity with a dismal prognosis in both HIV-negative and HIV-positive patients. Clinicians often face the question of second or third line treatment. As the treatment options with novel agents in lymphomas are rapidly evolving, more and more options beyond standard chemotherapy are available. In connection with a review of treatment options with novel lymphoma agents, we present a case report of a patient with a complete remission after the administration of brentuximab vedotin and lenalidomide...
December 23, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/28008939/csmap34-a-teleost-map-with-dual-role-a-promoter-of-masp-assisted-complement-activation-and-a-regulator-of-immune-cell-activity
#12
Mo-Fei Li, Jun Li, Li Sun
In teleost fish, the immune functions of mannan-binding lectin (MBL) associated protein (MAP) and MBL associated serine protease (MASP) are scarcely investigated. In the present study, we examined the biological properties both MAP (CsMAP34) and MASP (CsMASP1) molecules from tongue sole (Cynoglossus semilaevis). We found that CsMAP34 and CsMASP1 expressions occurred in nine different tissues and were upregulated by bacterial challenge. CsMAP34 protein was detected in blood, especially during bacterial infection...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27979761/crystallization-of-probucol-from-solution-and-the-glassy-state
#13
Kohsaku Kawakami, Chie Ohba
Crystallization of probucol (PBL) from both solution and glassy solid state was investigated. In the crystallization study from solution, six solvents and three methods, i.e., evaporation, addition of a poor solvent, and cooling on ice, were used to obtain various crystal forms. In addition to common two crystal forms (forms I and II), two further forms (forms III and cyclohexane-solvate) were found in this study, and their thermodynamic relationships were determined. Forms I and II are likely to be enantiotropically related with thermodynamic transition temperature below 5°C...
December 12, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27966518/impact-of-highly-active-antiretroviral-therapy-in-the-development-and-remission-of-oral-plasmablastic-lymphoma
#14
Vivian Petersen Wagner, Lisley Ortiz, Helena Pereira Rodrigues da Silva, Luise Meurer, João Julio da Cunha Filho, Marco Antonio Trevizani Martins, Manoela Domingues Martins
Plasmablastic lymphoma (PBL) represents a rare type of non-Hodgkin lymphoma associated with human immunodeficiency virus (HIV) infection. The impact of highly active antiretroviral therapy (HAART) in this tumor is poorly known due to its small incidence. This study reports a case of a 33-year-old HIV-positive woman who was referred to the Stomatology Department complaining about a painful gingival growth and cervical nodule both with 20 days of evolution. The lesions appeared 7 months after the patient stopped HAART...
September 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/27957358/bortezomib-ifosfamide-carboplatin-and-etoposide-in-a-patient-with-hiv-negative-relapsed-plasmablastic-lymphoma
#15
Mehmet Akce, Elaine Chang, Mohammad Haeri, Mike Perez, Christie J Finch, Mark M Udden, Martha P Mims
Plasmablastic lymphoma (PBL) is a rare subtype of diffuse large B cell lymphoma (DLBCL), often associated with HIV infection. We present a case of a 53-year-old HIV-negative man with untreated hepatitis C viral infection who presented with abdominal pain and lymphadenopathy. Lymph node and bone marrow biopsies were consistent with plasmablastic lymphoma. He had partial response (PR) to 6 cycles of EPOCH but disease progressed seven weeks later. Repeat biopsy was consistent with plasmablastic lymphoma. Three cycles of bortezomib, ifosfamide, carboplatin, and etoposide (B-ICE) chemotherapy resulted in a partial response (PR)...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/27942381/problem-based-learning-in-medical-school-a-student-s-perspective
#16
Bliss J Chang
Problem-based learning (PBL) has been a concept in existence for decades yet its implementation in medical student education is limited. Considering the nature of a physician's work, PBL is a logical step towards developing students' abilities to synthesize and integrate foundational concepts into clinical medicine. Harvard's recently redesigned Pathways curriculum has shifted almost exclusively towards PBL in its one-year preclinical curriculum. This piece provides my thoughts, both derived from my own reflections as well as conversations and observations of my peers, on the effectiveness, advantages, and disadvantages of a PBL curriculum...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27942055/students-satisfaction-to-hybrid-problem-based-learning-format-for-basic-life-support-advanced-cardiac-life-support-teaching
#17
Geetanjali Chilkoti, Medha Mohta, Rachna Wadhwa, Ashok Kumar Saxena, Chhavi Sarabpreet Sharma, Neelima Shankar
BACKGROUND AND AIMS: Students are exposed to basic life support (BLS) and advanced cardiac life support (ACLS) training in the first semester in some medical colleges. The aim of this study was to compare students' satisfaction between lecture-based traditional method and hybrid problem-based learning (PBL) in BLS/ACLS teaching to undergraduate medical students. METHODS: We conducted a questionnaire-based, cross-sectional survey among 118 1(st)-year medical students from a university medical college in the city of New Delhi, India...
November 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27893409/strategies-for-improvement-of-wechat-pbl-teaching-experience-from-china
#18
Furong Zeng, Guangtong Deng, Zhao Wang, Shi Chang, Xiang Chen, Lin Qi, Xiongbing Zu, Longfei Liu
No abstract text is available yet for this article.
November 28, 2016: International Journal of Medical Education
https://www.readbyqxmd.com/read/27881659/glycosyl-phosphatidylinositol-gpi-anchored-anti-hiv-scfv-efficiently-protect-cd4-t-cells-from-hiv-1-infection-and-deletion-in-hu-pbl-mice
#19
Chaobaihui Ye, Weiming Wang, Liang Cheng, Guangming Li, Michael Wen, Qi Wang, Qing Zhang, Dan Li, Paul Zhou, Lishan Su
: Despite the success in viral inhibition and CD4 T cell recovery by highly active antiretroviral treatment (HAART), HIV-1 is still not curable due to the persistence of HIV-1 reservoir during treatment. One patient with acute myeloid leukemia who received allogeneic hematopoietic stem cell transplantation from homozygous CCR5 Δ32 donor has had no detectable viremia for 9 years after HAART cessation. This case has inspired a field of HIV-1 cure research focusing on engineering HIV-1 resistance of permissive cells...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27878103/role-of-rna-secondary-structure-in-emergence-of-compartment-specific-hepatitis-b-virus-immune-escape-variants
#20
Sibnarayan Datta, Runu Chakravarty
AIM: To investigate the role of subgenotype specific RNA secondary structure in the compartment specific selection of hepatitis B virus (HBV) immune escape mutations. METHODS: This study was based on the analysis of the specific observation of HBV subgenotype A1 in the serum/plasma, while subgenotype A2 with G145R mutation in the peripheral blood leukocytes (PBLs). Genetic variability found among the two subgenotypes was used for prediction and comparison of the full length pregenomic RNA (pgRNA) secondary structure and base pairings...
November 12, 2016: World Journal of Virology
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