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https://www.readbyqxmd.com/read/28220843/dusp1-promoter-methylation-in-peripheral-blood-leukocyte-is-associated-with-triple-negative-breast-cancer-risk
#1
Jing Li, Yanbo Chen, Hongyuan Yu, Jingshen Tian, Fengshun Yuan, Jialong Fan, Yupeng Liu, Lin Zhu, Fan Wang, Yashuang Zhao, Da Pang
DNA methylation is one of the most common epigenetic alterations, providing important information regarding cancer risk and prognosis. A case-control study (423 breast cancer cases, 509 controls) and a case-only study (326 cases) were conducted to evaluate the association of DUSP1 promoter methylation with breast cancer risk and clinicopathological characteristics. No significant association between DUSP1 methylation in peripheral blood leukocyte (PBL) DNA and breast cancer risk was observed. DUSP1 methylation was significantly associated with ER/PR-negative status; in particular, triple-negative breast cancer patients showed the highest frequency of DUSP1 methylation in both tumour DNA and PBL DNA...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28214365/peripheral-blood-leukocytes-show-differential-expression-of-tumour-progression-related-genes-in-colorectal-cancer-patients-who-have-a-postoperative-intra-abdominal-infection-a-prospective-matched-cohort-study
#2
S Alonso, X Mayol, L Nonell, S Salvans, M Pascual, M Pera
AIM: Anastomotic leak is associated with higher rates of recurrence after surgery for colorectal cancer. However, the mechanisms responsible are unknown. We hypothesized that the infection-induced inflammatory response may induce overexpression of tumour progression-related genes in immune cells. The aim was to investigate the effect of postoperative intra-abdominal infection on the gene expression patterns of peripheral blood leukocytes (PBL) after surgery for colorectal cancer. METHODS: Prospective matched cohort study...
February 18, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28213366/tumor-infiltrating-and-peripheral-blood-t-cell-immunophenotypes-predict-early-relapse-in-localized-clear-cell-renal-cell-carcinoma
#3
Nicolas A Giraldo, Etienne Becht, Yann Vano, Florent Petitprez, Laetitia Lacroix, Pierre Validire, Rafael Sanchez-Salas, Alexandre Ingels, Stephane Marie Oudard, Audrey Moatti, Bénédicte Buttard, Sarah Bourras, Claire Germain, Xavier Cathelineau, Wolf-Herman Fridman, Catherine Sautes-Fridman
PURPOSE: The efficacy of PD-1 Checkpoint Blockade (ChB) as adjuvant therapy in localized clear cell Renal Cell Carcinoma (ccRCC) is currently unknown. The identification of tumor microenvironment (TME) prognostic biomarkers in this setting may help to define which patients could benefit from ChB and to uncover new therapeutic targets. EXPERIMENTAL DESIGN: We performed multiparametric flow cytometry immunophenotypic analysis of T cells isolated from tumor tissue (TIL), adjacent non-malignant renal tissue (RIL) and peripheral blood (PBL), in a cohort of patients (n=40) with localized ccRCC...
February 17, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28212520/adp-ribosyl-cyclases-cd38-cd157-social-skills-and-friendship
#4
Anne Chong, Fabio Malavasi, Salomon Israel, Chiea Chuen Khor, Von Bing Yap, Mikhail Monakhov, Soo Hong Chew, Poh San Lai, Richard P Ebstein
Why some individuals seek social engagement while others shy away has profound implications for normal and pathological human behavior. Evidence suggests that oxytocin (OT), the paramount human social hormone, and CD38 that governs OT release, contribute to individual differences in social skills from intense social involvement to extreme avoidance that characterize autism. To explore the neurochemical underpinnings of sociality, CD38 expression of peripheral blood leukocytes (PBL) was measured in Han Chinese undergraduates...
January 16, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28211028/short-term-supra-physiological-rhgh-administration-induces-transient-dna-damage-in-peripheral-lymphocytes-of-healthy-women
#5
C Fantini, P Sgrò, M Pittaluga, A de Perini, I Dimauro, A Sartorio, D Caporossi, L Di Luigi
PURPOSE: While a good safety for recombinant human growth hormone (rhGH) therapy at replacement doses is recognized, a possible link between high concentration of the GH-IGF-I axis hormones and side negative effect has been reported. The aim of this pilot study was to assess whether a short-term exposure to supra-physiological doses of rhGH may affect DNA integrity in human lymphocytes (PBL). METHODS: Eighteen healthy Caucasian female (24.2 ± 3.5 years) were randomly included in a Control (n = 9) and rhGH administration group (n = 9, 3-week treatment)...
February 16, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28208882/pbl-trigger-design-by-medical-students-an-effective-active-learning-strategy-outside-the-classroom
#6
Maya Roche, Indira Kakkunje Adiga, Akshatha G Nayak
INTRODUCTION: Problem Based Learning (PBL) is known world over as an effective, active learning strategy with many benefits for the student. Usually, in medical schools, PBL triggers are designed by a well-trained group of faculty from basic and clinical sciences. The challenge was whether this task could be given to students in the first year of their curriculum and be executed by them effectively. AIM: To enhance active learning, comprehension and critical thinking with a view to promote horizontal and vertical integration between subjects...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207555/human-immunodeficiency-virus-negative-plasmablastic-lymphoma-a-case-report-and-literature-review
#7
Li Lin, Xudong Zhang, Meng Dong, Ling Li, Xinhua Wang, Lei Zhang, Xiaorui Fu, Zhenchang Sun, Jingjing Wu, Zhaoming Li, Yu Chang, Yingjun Wang, Zhiyuan Zhou, Mingzhi Zhang, Qingjiang Chen
RATIONALE: Plasmablastic lymphoma (PBL) is a rare subtype of human immunodeficiency virus (HIV)-related non-Hodgkin's lymphoma that predominantly manifests in the oral cavity. PATIENT CONCERNS: Three cases of HIV-negative PBL were reported. DIAGNOSES: HIV-negative PBL INTERVENTIONS:: The patient had undergone chemotherapy. OUTCOMES: Clinical outcomes were very poor in Cases 1 and 3; Case 2, whose diagnosis suggested no bone marrow involvement, is still alive...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28179311/telomere-length-and-risk-of-hepatocellular-carcinoma-a-nested-case-control-study-in-taiwan-cancer-screening-program-cohort
#8
Hui Zeng, Hui-Chen Wu, Qiao Wang, Hwai-I Yang, Chien-Jen Chen, Regina M Santella, Jing Shen
BACKGROUND: Telomere length (TL) measured in peripheral blood leucocytes (PBL) might be a useful biomarker to identify elevated cancer risk. PATIENTS AND METHODS: A case-control study which included 268 newly-diagnosed HCC cases and 536 matched controls, was conducted. Absolute TL in PBL was analyzed by quantitative real-time PCR. RESULTS: The overall median length of TL was not statistically shorter in HCC cases compared to healthy controls...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178916/development-of-an-interdisciplinary-pre-matriculation-program-designed-to-promote-medical-students-self-efficacy
#9
Anna Wirta Kosobuski, Abigail Whitney, Andrew Skildum, Amy Prunuske
BACKGROUND AND OBJECTIVES: A four-week interdisciplinary pre-matriculation program for Native American and rural medical students was created and its impact on students' transition to medical school was assessed. The program extends the goals of many pre-matriculation programs by aiming to increase not only students' understanding of basic science knowledge, but also to build student self-efficacy through practice with medical school curricular elements while developing their academic support networks...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28178915/the-relationship-between-the-monitored-performance-of-tutors-and-students-at-pbl-tutorials-and-the-marked-hypotheses-generated-by-students-in-a-hybrid-curriculum
#10
Jonas I Addae, Pradeep Sahu, Bidyadhar Sa
INTRODUCTION: There have been a number of published studies examining the link between the effectiveness of the problem-based learning (PBL) process and students' performance in examinations. In a hybrid PBL/lectures curriculum, the results of such studies are of limited use because of the difficulty in dissociating the knowledge gained at lectures from that gained through PBL-related activities. Hence, the objectives of this study were: (1) to develop an instrument to measure the performance of tutors and students at PBL tutorials, and (2) to explore the contribution of such performances to the marks attained by students from the hypotheses generated at PBL tutorials...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28166769/medical-graduates-preparedness-to-practice-a-comparison-of-undergraduate-medical-school-training
#11
Susan Miles, Joanne Kellett, Sam J Leinster
BACKGROUND: There is evidence that newly qualified doctors do not feel prepared to start work. This study examined views of first year Foundation doctors (F1s) regarding how prepared they felt by their undergraduate medical education for skills required during the first Foundation training year in relation to their type of training. METHOD: One-hundred and eighty two F1s completed a questionnaire during their first rotation of Foundation training. Analysis was conducted by type of medical school training: Problem-Based Learning (PBL), Traditional or Reformed...
February 6, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28118478/nursing-education-based-on-hybrid-problem-based-learning-the-impact-of-pbl-based-clinical-cases-on-a-pathophysiology-course
#12
Paulo Alexandre Oliveira Marques, Nuno Candido Maia Correia
No abstract text is available yet for this article.
January 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28116440/-application-of-pbl-combined-with-sp-method-in-during-course-practice-of-endodontics-for-undergraduate-dental-students
#13
Li-Na Shao, Li-Hong Qiu, Fu-Liang Zhan, Ming Xue
PURPOSE: To apply problem-based learning (PBL) combined with standardized patients(SP) in during-course practice of endodontics for undergraduate dental students, in order to improve the teaching quality. METHODS: One hundred and four undergraduate dental students of China Medical University School of Stomatology were randomly divided into 2 groups, 52 students in each group. One group were taught with PBL combined with SP while the other group with lecture-based learning (LBL) alone...
October 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28095521/evaluation-of-ultrashort-and-longer-implants-with-microrough-surfaces-results-of-a-24-to-36-month-prospective-study
#14
Luciano Malchiodi, Riccardo Caricasulo, Alessandro Cucchi, Raffaele Vinci, Enrico Agliardi, Enrico Gherlone
PURPOSE: The aim of this prospective study was to establish if ultrashort implants are a reliable therapeutic solution by evaluating their effect on mean crestal bone loss and assessing their survival and success rates. MATERIALS AND METHODS: Patients were treated using 6-, 9-, and 11-mm-long implants with sandblasted and acid-etched surfaces and fitted with fixed partial prostheses. Clinical and radiographic examinations were scheduled yearly. Data collected included the implant positioning site, implant length and diameter, peri-implant bone loss (PBL), and clinical and anatomical C/I ratios...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28078685/peer-assessment-of-professional-behaviours-in-problem-based-learning-groups
#15
Chris Roberts, Christine Jorm, Stacey Gentilcore, Jim Crossley
CONTEXT: Peer assessment of professional behaviour within problem-based learning (PBL) groups can support learning and provide opportunities to identify and remediate problem behaviours. OBJECTIVES: We investigated whether a peer assessment of learning behaviours in PBL is sufficiently valid to support decision making about student professional behaviours. METHODS: Data were available for two cohorts of students, in which each student was rated by all of their PBL group peers using a modified version of a previously validated scale...
January 12, 2017: Medical Education
https://www.readbyqxmd.com/read/28066900/boosting-of-post-exposure-human-t-cell-and-b-cell-recall-responses-in-vivo-by-burkholderia-pseudomallei-related-proteins
#16
Arnone Nithichanon, Louise J Gourlay, Gregory J Bancroft, Manabu Ato, Yoshimasa Takahashi, Ganjana Lertmemongkolchai
Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been exposed to the bacteria and have developed some immunity, which may have helped to prevent disease. Here, we used a humanized mouse model (hu-PBL-SCID), reconstituted with human peripheral blood mononuclear cells from seropositive donors, to illustrate the potential of three known antigens (FliC, OmpA and N-PilO2) for boosting both T-cell and B-cell immune responses...
January 9, 2017: Immunology
https://www.readbyqxmd.com/read/28061800/does-a-pbl-based-medical-curriculum-predispose-training-in-specific-career-paths-a-systematic-review-of-the-literature
#17
REVIEW
Jordan Tsigarides, Laura R Wingfield, Myutan Kulendran
BACKGROUND: North American medical schools have used problem-based learning (PBL) structured medical education for more than 60 years. However, it has only recently been introduced in other medical schools outside of North America. Since its inception, there has been the debate on whether the PBL learning process predisposes students to select certain career paths. OBJECTIVES: To review available evidence to determine the predisposition of specific career paths when undertaking a PBL-based medical curriculum...
January 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28061777/whatsapp-messenger-as-a-tool-to-supplement-medical-education-for-medical-students-on-clinical-attachment
#18
Lewis Raiman, Richard Antbring, Asad Mahmood
BACKGROUND: Instant messaging applications have the potential to improve and facilitate communication between hospital doctors and students, hence generating and improving learning opportunities. This study aims to demonstrate the feasibility and acceptability of instant messaging communication to supplement medical education for medical students whilst on clinical attachment. METHODS: A total of 6 WhatsApp Messenger (WhatsApp Inc.) groups were created for medical students on clinical attachment...
January 6, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28056862/association-between-telomere-length-and-the-risk-of-colorectal-cancer-a-meta-analysis-of-observational-studies
#19
Cho Naing, Kyan Aung, Pei Kuan Lai, Joon Wah Mak
BACKGROUND: Human chromosomes are capped and stabilized by telomeres. Telomere length regulates a 'cellular mitotic clock' that defines the number of cell divisions and hence, cellular life span. This study aimed to synthesize the evidence on the association between peripheral blood leucocytes (PBL) telomere length and the risk of colorectal cancer (CRC). METHODS: We searched relevant studies in electronic databases. When two or more observational studies reported the same outcome measures, we performed pooled analysis...
January 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28050411/faculty-perception-towards-a-hybrid-problem-based-learning-methodology
#20
Nitin Joseph, Animesh Jain, Shashidhar M Kotian
This sequential quantitative and qualitative study was done to assess the perception of faculties towards a hybrid Problem Based Learning (PBL) methodology. To begin with, all faculty members of the department featured in a round of PBL facilitation. Later in phase I, their perception was assessed using a validated self-administered questionnaire. In phase II, personalized interview was conducted with each faculty. Finally phase (III) involved a focus group discussion on issues identified in previous phases...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
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