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https://www.readbyqxmd.com/read/28540354/data-on-the-exon-intron-organization-of-genes-coding-for-b-cell-receptor-like-proteins
#1
Sergey Y Morozov, Anna V Pankratenko, Anastasia K Atabekova, Andrey G Solovyev
B-cell receptor-associated protein (BAP) family plays important roles in the ER homeostasis and stress responses of eukaryotic cells [1]. We reported the analysis of plant BAP-like (PBL) genes and the encoded proteins of higher land plants [2]. The origin and functional divergence of these genes among all eukaryotes, however, are poorly studied, which impedes our understanding of the functional relationships and diversity among BAP-like proteins. One possible reason for the potential functional diversity may be the differences in the exon-intron structure of PBL genes...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28526918/effect-of-problem-and-scripting-based-learning-on-spine-surgical-trainees-learning-outcomes
#2
Lin Cong, Qi Yan, Chenjing Sun, Yue Zhu, Guanjun Tu
PURPOSE: To assess the impact of problem and scripting-based learning (PSBL) on spine surgical trainees' learning outcomes. METHODS: 30 spine surgery postgraduate-year-1 residents (PGY-1s) from the First Hospital of China Medical University were randomly divided into two groups. The first group studied spine surgical skills and developed individual judgment under a conventional didactic model, whereas the PSBL group used PBL and Scripted model. A feedback questionnaire and the satisfaction of residents were evaluated by the first assistant surgeon immediately following each procedure...
May 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28510806/role-of-core-needle-biopsy-in-primary-breast-lymphoma
#3
Giulia Bicchierai, Luigi Rigacci, Vittorio Miele, Icro Meattini, Diego De Benedetto, Valeria Selvi, Simonetta Bianchi, Lorenzo Livi, Jacopo Nori
Primary breast lymphoma (PBL) may mimic carcinoma clinically and also mammographic and ecographic distinction is subtle. Despite its rarity, incidence of PBLs has increased over the last four decades and continues to increase for younger women and for some subtypes, and for this reason it is increasingly important to achieve a preoperative pathological diagnosis using core needle biopsy (CNB) or fine-needle aspiration cytology (FNA). The aim of this retrospective study was to report our single-center experience in CNBs performed for histological diagnosis of PBL compared to FNA...
May 16, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28495564/characterization-of-toll-like-receptor-22-in-turbot-scophthalmus-maximus
#4
Jing Xing, Xiujuan Zhou, Xiaoqian Tang, Xiuzhen Sheng, Wenbin Zhan
Toll-like receptors (TLRs) are essential for activation of the innate immune system in response to invading pathogens. In this paper, expression profiles of the turbot (Scophthalmus maximus) TLR22 gene (tbTLR22) were analyzed with RT-PCR and in situ hybridization. Then its expression patterns simulated with ligands or pathogens were investigated. Streptococcus iniae, Edwardsiella tarda, Hirame rhabdovirus virus (HIRRV), polyinosinic: polycytidylic acid (Poly I:C), peptidoglycan (PGN), or lipopolysaccharides (LPS) was injected to turbot; poly I:C, PGN, or LPS was added into cultured peripheral blood leukocytes (PBL); and then the tbTLR22 in liver, spleen, gill, kidney and cultured PBL was measured using Quantitative PCR...
May 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28494627/problem-based-learning-in-occupational-therapy-curriculum-implications-and-challenges
#5
Michal Avrech Bar, Margalit Pade, Tal Jarus, Sarah Gat, Yael Kaufman Cohen, Lena Lipskaya-Velikovsky
PURPOSE: Problem-based learning (PBL) is an educational method that fosters self-directed study in small groups. The purpose of this study was to describe the Tel Aviv University's occupational therapy (OT) program and the challenges implementing such program. In addition, the study compared the PBL grades obtained by students who are native Hebrew speakers with those students who are native Arabic speakers; and, assessed the correlation between the grades in the PBL course and the grades in the clinical fieldwork studies...
May 11, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28485344/plasmablastic-lymphoma-of-the-gastrointestinal-tract-a-rare-entity-with-a-dismal-prognosis
#6
A S Komaranchath, R A Haleshappa, L C Kuntegowdenahalli, R V Kumar, L Dasappa, G Babu
INTRODUCTION: Plasmablastic lymphoma (PBL) is a rare and aggressive type of mature B-cell lymphoma, which is usually associated with HIV infection. The most common site of PBL is the oral cavity. Involvement of the gastrointestinal (GI) tract is rare, and literature is limited to few case reports and case series. AIMS: To retrospectively analyze the presentation, clinical findings, and outcome of patients presenting to our institute with a diagnosis of PBL involving the GI tract...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28483552/inhibition-of-cyclosporine-a-or-rapamycin-on-t-lymphocyte-counts-and-the-influence-on-the-immune-responses-of-b-lymphocytes-in-flounder-paralichthys-olivaceus
#7
Jing Xing, Yue'e Xiao, Xiaoqian Tang, Xiuzhen Sheng, Wenbin Zhan
In acquired immunity, T lymphocytes regulate the immune responses of B lymphocytes, including the IgM(+) B lymphocyte counts and antibody production. In this paper, Cyclosporine A (CsA) and Rapamycin (RaPa) were used, and their inhibition on T lymphocytes and immune responses of B lymphocytes in flounder (Paralichthys olivaceus) were investigated. Flounder was injected with Keyhole Limpet Hemocyanin (KLH), a mixture of KLH and CsA (KLH + CsA), or a mixture of KLH and RaPa (KLH + RaPa). Then, the proportions of T and IgM(+) B lymphocytes (PT and PB) in peripheral blood leukocytes (PBL) were analysed by flow cytometry (FCM), total antibodies (TA) and KLH specific antibodies (KA) in serum were measured by ELISA, and expression of 9 immune-related genes in the spleen and kidneys were determined using q-PCR...
May 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28483195/identification-of-immunogenic-proteins-and-evaluation-of-four-recombinant-proteins-as-potential-vaccine-antigens-from-vibrio-anguillarum-in-flounder-paralichthys-olivaceus
#8
Jing Xing, Hongsen Xu, Yang Wang, Xiaoqian Tang, Xiuzhen Sheng, Wenbin Zhan
Vibrio anguillarum is a severe bacterial pathogen that can infect a wide range of fish species. Identification of immunogenic proteins and development of vaccine are essential for disease prevention. In this study, immunogenic proteins were screened and identified from V. anguillarum, and then protective efficacy of the immunogenic proteins was evaluated. Immunogenic proteins in V. anguillarum whole cell were detected by Western blotting (WB) using immunized flounder (Paralichthys olivaceus) serum, and then identified by Mass spectrometry (MS)...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28476162/castanea-sativa-mill-bark-extract-exhibits-chemopreventive-properties-triggering-extrinsic-apoptotic-pathway-in-jurkat-cells
#9
Monia Lenzi, Marco Malaguti, Veronica Cocchi, Silvana Hrelia, Patrizia Hrelia
BACKGROUND: Chemoprevention represents the possibility to prevent, stop or reverse the cancerogenetic process. In this context the interest towards natural extracts and botanical drugs has constantly grown due to their phytochemical content. Castanea sativa Mill. (CSM) extracts showed to exert positive effect in the prevention/counteraction of chronic/degenerative diseases, therefore, we evaluated the potential chemopreventive effect of CSM bark extract. METHODS: Flow cytometry (FCM) analyses of Jurkat cells treated with CSM bark extract (0-500 μg·mL(-1)) for 24-72 h allowed evaluating its cytotoxicity and ability to induce apoptosis through the intrinsic or extrinsic pathways...
May 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28474477/evaluation-of-an-innovative-evidence-guided-pbl-approach
#10
Hilary Neve, Stephanie Bull, Helen Lloyd, Kerry Gilbert, Karen Mattick
AIM: To understand the experiences of students and problem-based learning (PBL) facilitators during an evidence-based curriculum change to a PBL programme within an undergraduate medical course in South West England. METHODS: Four novel PBL cases were designed and implemented, based on educational theory and evidence. Eight focus groups were undertaken with Year-1 and -2 students (n = 18) and PBL facilitators (n = 14) to explore the experiences of participants...
May 5, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/28473206/syd985-a-novel-duocarmycin-based-her2-targeting-antibody-drug-conjugate-shows-promising-antitumor-activity-in-epithelial-ovarian-carcinoma-with-her2-neu-expression
#11
Gulden Menderes, Elena Bonazzoli, Stefania Bellone, Jonathan Black, Gary Altwerger, Alice Masserdotti, Francesca Pettinella, Luca Zammataro, Natalia Buza, Pei Hui, Serena Wong, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Gloria S Huang, Masoud Azodi, Peter E Schwartz, Alessandro D Santin
BACKGROUND: Epithelial ovarian cancer (EOC) is an aggressive and heterogeneous disease. <10% of EOC demonstrate HER2/neu 3+ receptor over-expression. However, moderate to low (i.e., 2+ and 1+) HER2/neu expression is reported in up to 50% of EOC. The objective of this study was to compare the anti-tumor activity of SYD985, a novel HER2-targeting antibody-drug conjugate (ADC), to trastuzumab emtansine (T-DM1) in EOC models with differential HER2/neu expression. METHODS: The cytotoxicity of SYD985 and T-DM1 was evaluated using ten primary EOC cell lines with 0/1+, 2+, and 3+ HER2/neu expression in antibody-dependent cellular cytotoxicity (ADCC), proliferation, viability and bystander killing experiments...
May 1, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28468706/problem-based-learning-for-didactic-presentation-to-baccalaureate-nursing-students
#12
Susan Montenery
Nursing judgment is an essential component in the delivery of safe, quality patient care. Nurses must have the knowledge and skills to question authority, make judgments, substantiate evidence, and advocate for the patient. Traditional pedagogy in content-laden courses remains primarily lecture based. Incorporating active strategies to strengthen professional practice is essential. A pilot study assessed senior baccalaureate nursing students' perceptions of problem-based learning (PBL) and their readiness for self-directed learning...
May 1, 2017: Creative Nursing
https://www.readbyqxmd.com/read/28468089/-clinical-characteristics-and-survival-analysis-of-eight-cases-hiv-negative-plasmablastic-lymphoma
#13
X Han, L X Hu, M Q Ouyang, M H Duan, D B Zhou
Objective: To deepen the knowledge of HIV-negative plasmablastic lymphoma (PBL) . Methods: Medical records from 8 HIV-negative PBL patients diagnosed in Peking Union Medical College Hospital from January 1997 to May 2015 were collected, and the clinical features and prognosis of these patients were analyzed. Results: All of these 8 patients were diagnosed as HIV-negative PBL, 3 of 8 patients were males, and others were female. The median age was 60 (43-80) year. Among these patients, 4 cases had underlying immunosuppressive state...
April 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28463733/investigation-of-self-compassion-self-confidence-and-submissive-behaviors-of-nursing-students-studying-in-different-curriculums
#14
Şahizer Eraydın, Şerife Karagözoğlu
INTRODUCTION: Today, nursing education which educates the future members of the nursing profession aims to gain them high self-esteem, selfconfidence and self-compassion, independence, assertiveness and ability to establish good human relations. This aim can only be achieved through a contemporary curriculum supporting students in the educational process and enabling those in charge to make arrangements by taking the characters and needs of each individual into account. OBJECTIVE: The study aims to investigate self-compassion, self-confidence and submissive behaviours of undergraduate nursing students studying in different curriculums...
April 12, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28446320/-advances-in-diagnosis-and-treatment-of-primary-breast-lymphoma-review
#15
Zhong-Ling Wei, Dong-Ping Huang
Primary breast lymphoma(PBL) is a rare and unique type of lymphoma. Female patients are the majority, but its pathogenesis is not clear, and the estrogen may be related with the pathoganesis. Women who have breast implants have more chance to be suffered. The painless breast masses are the most common clinical manifestations, which is similar to breast cancer. Surgical resection of the mass and core needle biopsy are helpful for the diagnosis. The most common pathological type of PBL is diffuse large B cell type, with non GCB type, and it is prone to extranodal relapse in which central nervous system relapse is common which has poor prognosis...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28414998/a-qualitative-study-on-using-concept-maps-in-problem-based-learning
#16
Zenobia C Y Chan
BACKGROUND: The visual arts, including concept maps, have been shown to be effective tools for facilitating student learning. However, the use of concept maps in nursing education has been under-explored. OBJECTIVES: The aim of this study was to explore how students develop concept maps and what these concept maps consist of, and their views on the use of concept maps as a learning activity in a PBL class. DESIGN: A qualitative approach consisting of an analysis of the contents of the concept maps and interviews with students...
April 12, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28403103/primary-bone-lymphoma-of-radius-and-tibia-a-case-report-and-review-of-literature
#17
REVIEW
Yanmei Huan, Yiwei Qi, Weisheng Zhang, Jianguo Chu
RATIONALE: Primary bone lymphoma (PBL) is a rare malignant entity. There is a better survival of PBL than any other malignant bone tumors and extranodal lymphomas. PATIENT CONCERNS: We report a rare case of PBL involving radius and tibia. The patient was a 14-year-old girl with left forearm pain and swelling after trauma. Six months later after the last chemotherapy and radiotherapy, pain and swelling of left knee was presented. DIAGNOSES: Radiological imaging revealed a lytic destruction, periosteal reaction, and pathological fracture of radius and tibia with soft tissue mass...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28395155/short-term-variability-of-gamma-radiation-at-the-arm-eastern-north-atlantic-facility-azores
#18
S M Barbosa, P Miranda, E B Azevedo
This work addresses the short-term variability of gamma radiation measured continuously at the Eastern North Atlantic (ENA) facility located in the Graciosa island (Azores, 39N; 28W), a fixed site of the Atmospheric Radiation Measurement programme (ARM). The temporal variability of gamma radiation is characterized by occasional anomalies over a slowly-varying signal. Sharp peaks lasting typically 2-4 h are coincident with heavy precipitation and result from the scavenging effect of precipitation bringing radon progeny from the upper levels to the ground surface...
June 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28392172/decreased-gene-expression-of-cd2ap-in-chinese-patients-with-sporadic-alzheimer-s-disease
#19
Qing-Qing Tao, Zhi-Jun Liu, Yi-Min Sun, Hong-Lei Li, Ping Yang, De-Shan Liu, Bin Jiang, Xiao-Yan Li, Jian-Feng Xu, Zhi-Ying Wu
Many sporadic Alzheimer's disease (SAD) risk genes have been identified in the last decades, but most of them have not been consistently accepted. Here, we sought to identify SAD-associated genes and their potential mechanisms involved in SAD pathogenesis. A 2-stage design was employed. In stage 1, 95 variants in 75 genes that were previously reported as SAD-risk genes in Caucasian populations were evaluated in 1857 subjects (422 SAD patients and 1435 controls). In stage 2, a subset of promising variants found in stage 1 were further evaluated in an independent cohort of 1001 subjects (254 SAD and 747 controls)...
March 16, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28387869/genotoxicity-study-of-nickel-oxide-nanoparticles-in-female-wistar-rats-after-acute-oral-exposure
#20
Naresh Dumala, Bhanuramya Mangalampalli, Srinivas Chinde, Srinivas Indu Kumari, Mohammad Mahoob, Mohammad Fazlur Rahman, Paramjit Grover
Nanoparticles (NPs) apart from their widespread advantages and increased utilisation, have aroused concerns over their safe use. Nickel (II) oxides (NiO) NPs are used as catalysts, biosensors and in many of the consumer products. The increasing use of NiO NPs necessitates an improved understanding of their potential impact on the environment and human health. In this study, we investigated the acute genotoxic effects of NiO NPs by oral route administration with three different doses (125, 250 and 500 mg/kg bw)...
April 6, 2017: Mutagenesis
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