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https://www.readbyqxmd.com/read/28632009/self-observation-and-peer-feedback-as-a-faculty-development-approach-for-problem-based-learning-tutors-a-program-evaluation
#1
Irène Garcia, Richard W James, Paul Bischof, Anne Baroffio
PROBLEM: Good teaching requires spontaneous, immediate, and appropriate action in response to various situations. It is even more crucial in problem-based learning (PBL) tutorials, as the tutors, while directing students toward the identification and attainment of learning objectives, must stimulate them to contribute to the process and provide them with constructive feedback. PBL tutors in medicine lack opportunities to receive feedback from their peers on their teaching strategies. Moreover, as tutorials provide little or no time to stop and think, more could be learned by reflecting on the experience than from the experience itself...
March 2, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28631253/portal-branch-ligation-does-not-counteract-the-inhibiting-effect-of-temsirolimus-on-extrahepatic-colorectal-metastatic-growth
#2
Sebastian Senger, Jens Sperling, Barbara Oberkircher, Martin K Schilling, Otto Kollmar, Michael D Menger, Christian Ziemann
The mTor-inhibitor temsirolimus (TEM) has potent anti-tumor activities on extrahepatic colorectal metastases. Treatment of patients with advanced disease may require portal branch ligation (PBL). While PBL can induce intrahepatic tumor growth, the effect of PBL on extrahepatic metastases under TEM treatment is unknown. Therefore, we analyzed the effects of TEM treatment on extrahepatic metastases during PBL-associated liver regeneration. GFP-transfected CT26.WT colorectal cancer cells were implanted into the dorsal skinfold chamber of BALB/c-mice...
June 19, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28620384/measuring-leukocyte-adhesion-to-primary-endothelial-cells-after-photon-and-charged-particle-exposure-with-a-dedicated-laminar-flow-chamber
#3
Nadine Erbeldinger, Felicitas Rapp, Svetlana Ktitareva, Philipp Wendel, Anna S Bothe, Till Dettmering, Marco Durante, Thomas Friedrich, Bianca Bertulat, Stephanie Meyer, M C Cardoso, Stephanie Hehlgans, Franz Rödel, Claudia Fournier
The vascular endothelium interacts with all types of blood cells and is a key modulator of local and systemic inflammatory processes, for example, in the adhesion of blood leukocytes to endothelial cells (EC) and the following extravasation into the injured tissue. The endothelium is constantly exposed to mechanical forces caused by blood flow, and the resulting shear stress is essential for the maintenance of endothelial function. Changes in local hemodynamics are sensed by EC, leading to acute or persistent changes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28619525/murine-and-human-pancreatic-tumor-exosome-recovery-in-mouse-serum-diagnostic-and-prognostic-potential-and-target-cell-delivery
#4
Ulrike Erb, Kun Zhao, Zhe Wang, Li Xiao, Margot Zöller
Exosomes (Exo), powerful intercellular communicators, are recovered in all body fluids, suggesting suitability for diagnosis and prognosis. Easy in vitro manipulation recommends Exo as drug vehicles. Aiming to consolidate diagnostic and therapeutic potential of Exo, we evaluated recovery and fate of tumor (TEX) and exogenous Exo in syngeneic and xenogeneic mice bearing a murine or a human pancreatic adenocarcinoma. A significant increase in serum (S)-TEX was observed 2 weeks after tumor cell application. Instead, S-TEX declined within 3-6 days after tumor excision...
June 12, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28613279/nox-mediated-impairment-of-pdgf-induced-dna-synthesis-in-peripheral-blood-lymphocytes-of-children-with-idiopathic-nephrotic-syndrome
#5
Amal Al-Eisa, Gursev S Dhaunsi
BackgroundCellular oxidative stress, inflammatory responses, and immunogenic events are involved in pathogenesis of idiopathic nephrotic syndrome (INS); however, the exact mechanism remains unknown. We examined NADPH oxidase (NOX) activity and platelet-derived growth factor (PDGF)-induced DNA synthesis in peripheral blood lymphocytes (PBL) of patients with INS.MethodsPBL from 15 patients with INS and 15 age- and gender-matched controls were isolated, and enzyme activities of NOX, catalase, and superoxide dismutase (SOD) were measured along with the assay of malondialdehyde levels and bromo-deoxyuridine incorporation...
June 14, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28607019/in-vitro-in-vivo-discordance-with-humanized-piperacillin-tazobactam-exposures-against-piperacillin-tazobactam-resistant-pan-%C3%AE-lactam-susceptible-klebsiella-pneumoniae
#6
S M Stainton, M L Monogue, D P Nicolau
Recent findings have identified K. pneumoniae strains that are pan-β-lactam-susceptible (PBL-S), but piperacillin-tazobactam-resistant (TZP-R) in vitro We assessed the efficacy of a humanized exposure of TZP against 12 TZP-R/PBL-S K. pneumoniae isolates in an immunocompromised murine lung infection model. Discordance between the in vitro resistance profile and the in vivo efficacy of human simulated TZP exposures against this phenotypic profile was observed. Additional studies are required to define the clinical implications these TZP-R/PBL-S strains...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28600042/the-effectiveness-of-clinical-problem-based-learning-model-of-medico-jurisprudence-education-on-general-law-knowledge-for-obstetrics-gynecological-interns
#7
Hui-Chin Chang, Ning-Yen Wang, Wen-Ru Ko, You-Tsz Yu, Long-Yau Lin, Hui-Fang Tsai
OBJECTIVE: The effective education method of medico-jurisprudence for medical students is unclear. The study was designed to evaluate the effectiveness of problem-based learning (PBL) model teaching medico-jurisprudence in clinical setting on General Law Knowledge (GLK) for medical students. MATERIALS AND METHODS: Senior medical students attending either campus-based law curriculum or Obstetrics/Gynecology (Ob/Gyn) clinical setting morning meeting from February to July in 2015 were enrolled...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28597873/do-medical-students-generate-sound-arguments-during-small-group-discussions-in-problem-based-learning-an-analysis-of-preclinical-medical-students-argumentation-according-to-a-framework-of-hypothetico-deductive-reasoning
#8
Hyunjung Ju, Ikseon Choi, Bo Young Yoon
PURPOSE: Hypothetico-deductive reasoning (HDR) is an essential learning activity and a learning outcome in problem-based learning (PBL). It is important for medical students to engage in the HDR process through argumentation during their small group discussions in PBL. This study aimed to analyze the quality of preclinical medical students' argumentation according to each phase of HDR in PBL. METHODS: Participants were 15 first-year preclinical students divided into two small groups...
June 2017: Korean Journal of Medical Education
https://www.readbyqxmd.com/read/28584689/an-integrated-interactive-spaced-education-radiology-curriculum-for-preclinical-students
#9
Eli Tshibwabwa, Robert Mallin, Madeleine Fraser, Martin Tshibwabwa, Reza Sanii, James Rice, Jenifer Cannon
INTRODUCTION: The objective of this study is to determine whether a radiology module, together with online spaced education, helps students of an integrated problem-based learning (PBL) curriculum increase their radiology knowledge and long-term retention. MATERIALS AND METHODS: Second-year students at the American University of Antigua College of Medicine participated in small groups of ten students each into two 2 h of radiology laboratories. The study comprised two cohorts: winter and fall 2013 students (control group) and 2014 students (experimental group)...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28577118/comparing-and-contrasting-the-use-of-problem-based-learning-in-child-and-adolescent-psychiatry-programs
#10
Dale Peeples, Anthony Guerrero, Bettina Bernstein, Jeffrey Hunt, Say How Ong, Cynthia Santos, Sandra Sexson, Norbert Skokauskas
OBJECTIVE: Problem-based learning (PBL) is one of the core components of medical education. To facilitate the spread and use of PBL in child and adolescent psychiatry (CAP) fellowship training, a special interest study group (SISG) was formed at the American Academy of Child and Adolescent Psychiatry (AACAP). Different approaches to the implementation of PBL between programs represented at the SISG are compared in this report. METHODS: The authors distributed a survey to SISG participants after the 2015 annual AACAP meeting, which gathered information about the different approaches programs use to implement PBL in graduate medical education...
June 2, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28572421/do-dental-students-personality-types-and-group-dynamics-affect-their-performance-in-problem-based-learning
#11
Jung-Joon Ihm, So-Youn An, Deog-Gyu Seo
The aim of this study was to determine whether the personality types of dental students and their group dynamics were linked to their problem-based learning (PBL) performance. The Myers-Briggs Type Indicator (MBTI) instrument was used with 263 dental students enrolled in Seoul National University School of Dentistry from 2011 to 2013; the students had participated in PBL in their first year. A four-session PBL setting was designed to analyze how individual personality types and the diversity of their small groups were associated with PBL performance...
June 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28566569/influence-on-learning-of-a-collaborative-learning-method-comprising-the-jigsaw-method-and-problem-based-learning-pbl
#12
Kayoko Takeda, Kiyoshi Takahashi, Hiroyuki Masukawa, Yoshimitsu Shimamori
 Recently, the practice of active learning has spread, increasingly recognized as an essential component of academic studies. Classes incorporating small group discussion (SGD) are conducted at many universities. At present, assessments of the effectiveness of SGD have mostly involved evaluation by questionnaires conducted by teachers, by peer assessment, and by self-evaluation of students. However, qualitative data, such as open-ended descriptions by students, have not been widely evaluated. As a result, we have been unable to analyze the processes and methods involved in how students acquire knowledge in SGD...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28562330/the-correlation-between-pulmonary-fibrosis-and-methylation-of-peripheral-smad3-in-cases-of-pigeon-breeder-s-lung-in-a-chinese-uygur-population
#13
Chao Wu, Wei Ding, Qifeng Li, Wenyi Wang, Mingqin Deng, Rong Jin, Baosen Pang, Xiaohong Yang
Smad3 is a key protein in the transforming growth factor-beta (TGF-β)/Smad signaling pathway, which is involved in fibrosis in many organs. We investigated the relationship between Smad3 gene methylation and pulmonary fibrosis in pigeon breeder's lung (PBL). Twenty Uygur PBL patients with pulmonary fibrosis in Kashi between October 2015 and March 2016 were enrolled. Twenty PBL-free pigeon breeders and 20 healthy non-pigeon breeders enrolled during the same period constituted the negative and normal control groups, respectively...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28540354/data-on-the-exon-intron-organization-of-genes-coding-for-b-cell-receptor-like-proteins
#14
Sergey Y Morozov, Anna V Pankratenko, Anastasia K Atabekova, Andrey G Solovyev
B-cell receptor-associated protein (BAP) family plays important roles in the ER homeostasis and stress responses of eukaryotic cells [1]. We reported the analysis of plant BAP-like (PBL) genes and the encoded proteins of higher land plants [2]. The origin and functional divergence of these genes among all eukaryotes, however, are poorly studied, which impedes our understanding of the functional relationships and diversity among BAP-like proteins. One possible reason for the potential functional diversity may be the differences in the exon-intron structure of PBL genes...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28526918/effect-of-problem-and-scripting-based-learning-on-spine-surgical-trainees-learning-outcomes
#15
Lin Cong, Qi Yan, Chenjing Sun, Yue Zhu, Guanjun Tu
PURPOSE: To assess the impact of problem and scripting-based learning (PSBL) on spine surgical trainees' learning outcomes. METHODS: 30 spine surgery postgraduate-year-1 residents (PGY-1s) from the First Hospital of China Medical University were randomly divided into two groups. The first group studied spine surgical skills and developed individual judgment under a conventional didactic model, whereas the PSBL group used PBL and Scripted model. A feedback questionnaire and the satisfaction of residents were evaluated by the first assistant surgeon immediately following each procedure...
May 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28510806/role-of-core-needle-biopsy-in-primary-breast-lymphoma
#16
Giulia Bicchierai, Luigi Rigacci, Vittorio Miele, Icro Meattini, Diego De Benedetto, Valeria Selvi, Simonetta Bianchi, Lorenzo Livi, Jacopo Nori
Primary breast lymphoma (PBL) may mimic carcinoma clinically and also mammographic and ecographic distinction is subtle. Despite its rarity, incidence of PBLs has increased over the last four decades and continues to increase for younger women and for some subtypes, and for this reason it is increasingly important to achieve a preoperative pathological diagnosis using core needle biopsy (CNB) or fine-needle aspiration cytology (FNA). The aim of this retrospective study was to report our single-center experience in CNBs performed for histological diagnosis of PBL compared to FNA...
May 16, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28495564/characterization-of-toll-like-receptor-22-in-turbot-scophthalmus-maximus
#17
Jing Xing, Xiujuan Zhou, Xiaoqian Tang, Xiuzhen Sheng, Wenbin Zhan
Toll-like receptors (TLRs) are essential for activation of the innate immune system in response to invading pathogens. In this paper, expression profiles of the turbot (Scophthalmus maximus) TLR22 gene (tbTLR22) were analyzed with RT-PCR and in situ hybridization. Then its expression patterns simulated with ligands or pathogens were investigated. Streptococcus iniae, Edwardsiella tarda, Hirame rhabdovirus virus (HIRRV), polyinosinic: polycytidylic acid (Poly I:C), peptidoglycan (PGN), or lipopolysaccharides (LPS) was injected to turbot; poly I:C, PGN, or LPS was added into cultured peripheral blood leukocytes (PBL); and then the tbTLR22 in liver, spleen, gill, kidney and cultured PBL was measured using Quantitative PCR...
May 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28494627/problem-based-learning-in-occupational-therapy-curriculum-implications-and-challenges
#18
Michal Avrech Bar, Margalit Pade, Tal Jarus, Sarah Gat, Yael Kaufman Cohen, Lena Lipskaya-Velikovsky
PURPOSE: Problem-based learning (PBL) is an educational method that fosters self-directed study in small groups. The purpose of this study was to describe the Tel Aviv University's occupational therapy (OT) program and the challenges implementing such program. In addition, the study compared the PBL grades obtained by students who are native Hebrew speakers with those students who are native Arabic speakers; and, assessed the correlation between the grades in the PBL course and the grades in the clinical fieldwork studies...
May 11, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28485344/plasmablastic-lymphoma-of-the-gastrointestinal-tract-a-rare-entity-with-a-dismal-prognosis
#19
A S Komaranchath, R A Haleshappa, L C Kuntegowdenahalli, R V Kumar, L Dasappa, G Babu
INTRODUCTION: Plasmablastic lymphoma (PBL) is a rare and aggressive type of mature B-cell lymphoma, which is usually associated with HIV infection. The most common site of PBL is the oral cavity. Involvement of the gastrointestinal (GI) tract is rare, and literature is limited to few case reports and case series. AIMS: To retrospectively analyze the presentation, clinical findings, and outcome of patients presenting to our institute with a diagnosis of PBL involving the GI tract...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28483552/inhibition-of-cyclosporine-a-or-rapamycin-on-t-lymphocyte-counts-and-the-influence-on-the-immune-responses-of-b-lymphocytes-in-flounder-paralichthys-olivaceus
#20
Jing Xing, Yue'e Xiao, Xiaoqian Tang, Xiuzhen Sheng, Wenbin Zhan
In acquired immunity, T lymphocytes regulate the immune responses of B lymphocytes, including the IgM(+) B lymphocyte counts and antibody production. In this paper, Cyclosporine A (CsA) and Rapamycin (RaPa) were used, and their inhibition on T lymphocytes and immune responses of B lymphocytes in flounder (Paralichthys olivaceus) were investigated. Flounder was injected with Keyhole Limpet Hemocyanin (KLH), a mixture of KLH and CsA (KLH + CsA), or a mixture of KLH and RaPa (KLH + RaPa). Then, the proportions of T and IgM(+) B lymphocytes (PT and PB) in peripheral blood leukocytes (PBL) were analysed by flow cytometry (FCM), total antibodies (TA) and KLH specific antibodies (KA) in serum were measured by ELISA, and expression of 9 immune-related genes in the spleen and kidneys were determined using q-PCR...
May 5, 2017: Fish & Shellfish Immunology
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