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https://www.readbyqxmd.com/read/28414998/a-qualitative-study-on-using-concept-maps-in-problem-based-learning
#1
Zenobia C Y Chan
BACKGROUND: The visual arts, including concept maps, have been shown to be effective tools for facilitating student learning. However, the use of concept maps in nursing education has been under-explored. OBJECTIVES: The aim of this study was to explore how students develop concept maps and what these concept maps consist of, and their views on the use of concept maps as a learning activity in a PBL class. DESIGN: A qualitative approach consisting of an analysis of the contents of the concept maps and interviews with students...
April 12, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28403103/primary-bone-lymphoma-of-radius-and-tibia-a-case-report-and-review-of-literature
#2
Yanmei Huan, Yiwei Qi, Weisheng Zhang, Jianguo Chu
RATIONALE: Primary bone lymphoma (PBL) is a rare malignant entity. There is a better survival of PBL than any other malignant bone tumors and extranodal lymphomas. PATIENT CONCERNS: We report a rare case of PBL involving radius and tibia. The patient was a 14-year-old girl with left forearm pain and swelling after trauma. Six months later after the last chemotherapy and radiotherapy, pain and swelling of left knee was presented. DIAGNOSES: Radiological imaging revealed a lytic destruction, periosteal reaction, and pathological fracture of radius and tibia with soft tissue mass...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28395155/short-term-variability-of-gamma-radiation-at-the-arm-eastern-north-atlantic-facility-azores
#3
S M Barbosa, P Miranda, E B Azevedo
This work addresses the short-term variability of gamma radiation measured continuously at the Eastern North Atlantic (ENA) facility located in the Graciosa island (Azores, 39N; 28W), a fixed site of the Atmospheric Radiation Measurement programme (ARM). The temporal variability of gamma radiation is characterized by occasional anomalies over a slowly-varying signal. Sharp peaks lasting typically 2-4 h are coincident with heavy precipitation and result from the scavenging effect of precipitation bringing radon progeny from the upper levels to the ground surface...
April 7, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28392172/decreased-gene-expression-of-cd2ap-in-chinese-patients-with-sporadic-alzheimer-s-disease
#4
Qing-Qing Tao, Zhi-Jun Liu, Yi-Min Sun, Hong-Lei Li, Ping Yang, De-Shan Liu, Bin Jiang, Xiao-Yan Li, Jian-Feng Xu, Zhi-Ying Wu
Many sporadic Alzheimer's disease (SAD) risk genes have been identified in the last decades, but most of them have not been consistently accepted. Here, we sought to identify SAD-associated genes and their potential mechanisms involved in SAD pathogenesis. A 2-stage design was employed. In stage 1, 95 variants in 75 genes that were previously reported as SAD-risk genes in Caucasian populations were evaluated in 1857 subjects (422 SAD patients and 1435 controls). In stage 2, a subset of promising variants found in stage 1 were further evaluated in an independent cohort of 1001 subjects (254 SAD and 747 controls)...
March 16, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28387869/genotoxicity-study-of-nickel-oxide-nanoparticles-in-female-wistar-rats-after-acute-oral-exposure
#5
Naresh Dumala, Bhanuramya Mangalampalli, Srinivas Chinde, Srinivas Indu Kumari, Mohammad Mahoob, Mohammad Fazlur Rahman, Paramjit Grover
Nanoparticles (NPs) apart from their widespread advantages and increased utilisation, have aroused concerns over their safe use. Nickel (II) oxides (NiO) NPs are used as catalysts, biosensors and in many of the consumer products. The increasing use of NiO NPs necessitates an improved understanding of their potential impact on the environment and human health. In this study, we investigated the acute genotoxic effects of NiO NPs by oral route administration with three different doses (125, 250 and 500 mg/kg bw)...
April 6, 2017: Mutagenesis
https://www.readbyqxmd.com/read/28377331/problem-based-learning-in-laboratory-medicine-resident-education-a-satisfaction-survey
#6
Quentin Lepiller, Morgane Solis, Aurélie Velay, Pierre Gantner, Charlotte Sueur, Françoise Stoll-Keller, Heidi Barth, Samira Fafi-Kremer
Theoretical knowledge in biology and medicine plays a substantial role in laboratory medicine resident education. In this study, we assessed the contribution of problem-based learning (PBL) to improve the training of laboratory medicine residents during their internship in the department of virology, Strasbourg University Hospital, France. We compared the residents' satisfaction regarding an educational program based on PBL and a program based on lectures and presentations. PBL induced a high level of satisfaction (100%) among residents compared to lectures and presentations (53%)...
April 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28376147/primary-breast-lymphoma-in-the-united-states-1975-2013
#7
Alexandra Thomas, Brian K Link, Sean Altekruse, Paul A Romitti, Mary C Schroeder
Background: Primary breast lymphoma (PBL) has gained attention with the description of breast implant-associated anaplastic large cell lymphoma (ALCL). Less is known about PBL incidence, treatment, and survival by lymphoma subtype. Methods: The Surveillance, Epidemiology, and End Results (SEER) registry database was queried for patients with PBL as first malignancy, with attention to non-Hodgkin Lymphoma PBL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, marginal zone lymphoma (MZL), and ALCL...
June 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28365611/top-cited-articles-in-problem-based-learning-a-bibliometric-analysis-and-quality-of-evidence-assessment
#8
REVIEW
Samy A Azer
The aims of this study were to identify characteristics of the top-cited articles in problem-based learning (PBL) and assess the quality of evidence provided by these articles. The most frequently cited articles on PBL were searched in April 2015 in the Science Citation Index Expanded database (List A) and Google Scholar database (List B). Eligible articles identified were reviewed for key characteristics. The Oxford Centre for Evidence-Based Medicine guidelines were used in assessing the level of evidence...
April 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28364472/transcriptional-signatures-of-sleep-duration-discordance-in-monozygotic-twins
#9
N F Watson, D Buchwald, J J Delrow, W A Altemeier, M V Vitiello, A I Pack, M Bamshad, C Noonan, S A Gharib
Introduction: Habitual short sleep duration is associated with adverse metabolic, cardiovascular, and inflammatory effects. Co-twin study methodologies account for familial (eg, genetics and shared environmental) confounding, allowing assessment of subtle environmental effects, such as the effect of habitual short sleep duration on gene expression. Therefore, we investigated gene expression in monozygotic twins discordant for actigraphically phenotyped habitual sleep duration. Methods: Eleven healthy monozygotic twin pairs (82% female; mean age 42...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28356993/primary-breast-lymphoma-a-single-center-study
#10
Na Zhang, Caineng Cao, Yuan Zhu, Peng Liu, Luying Liu, Ke Lu, Jialin Luo, Ning Zhou
The aim of the present study was to summarize the clinical characteristics of primary breast lymphoma (PBL) and evaluate its management approaches. A total of 29 patients newly diagnosed with PBL, and treated between April 2006 and May 2013, were analyzed retrospectively. The median survival follow-up time for all patients was 66.8 (range, 25.4-110.0) months. The results of the follow-up revealed 22 living lymphoma-free patients and 7 patients who had succumbed to PBL. Of the 7 deceased patients, 6 had succumbed to lymphoma and 1 to chemotherapy-associated hepatic failure...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28344874/high-baseline-levels-of-interleukin-8-in-leukocytes-and-urine-predict-tumor-recurrence-in-non-muscle-invasive-bladder-cancer-patients-receiving-bacillus-calmette-guerin-therapy-a-long-term-survival-analysis
#11
Kai Qu, Jian Gu, Yuanqing Ye, Stephen B Williams, Colin P Dinney, Xifeng Wu, Ashish Kamat
Bacillus Calmette-Guerin (BCG) therapy for non-muscle invasive bladder cancer (NMIBC) can significantly reduce the risk of recurrence and progression. However, BCG therapy may fail in up to a half of treated patients and may also cause toxicities. Biomarkers to predict the effectiveness of BCG therapy are desired to pre-select patients for BCG therapy to maximize efficacy while avoid unnecessary toxicity. Twelve cytokines were measured in 100 blood and 112 urine samples using cytokine antibody array and correlated with recurrence-free survival in overall and BCG-treated NMIBC patients...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28331851/predicting-factors-for-allogeneic-blood-transfusion-and-excessive-postoperative-blood-loss-after-single-low-dosage-intra-articular-tranexamic-acid-application-in-total-knee-replacement
#12
Paphon Sa-Ngasoongsong, Siwadol Wongsak, Noratep Kulachote, Pongsthorn Chanplakorn, Patarawan Woratanarat, Viroj Kawinwonggowit
Background. Recently, intra-articular tranexamic acid (IA-TXA) application has become a popular method for perioperative blood loss (PBL) reduction in total knee replacement (TKR). Nevertheless, through our knowledge, no previous studies had shown the correlation perioperative factors and the risk of excessive PBL or need of blood transfusion (BT) after IA-TXA. Materials and Methods. A retrospective study was conducted in patients underwent 299 primary TKRs, using IA-TXA, during 2-year period (2013-2014). Patient's characteristic and perioperative data were reviewed and collected...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28321020/assessment-of-dna-damage-in-leukocytes-of-patients-with-coronary-artery-disease-by-comet-assay
#13
Mohd Akbar Bhat, Gursatej Gandhi
DNA damage in the peripheral blood leukocytes (PBL) of patients with coronary artery disease (CAD) was investigated using the sensitive alkaline single cell gel electrophoresis (SCGE)/comet assay.This case-control study consisted of CAD patients (n = 200; mean age, 59.04 ± 0.75 years) undergoing treatment at local hospitals and age-, sex-, and ethnicity-matched healthy controls (n = 200; mean age, 57.88 ± 0.96 years) from the general population.CAD patients had significantly (P < 0.001) increased DNA damage (tail DNA percent (T-DNA %) 22...
March 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28317488/association-between-periodontal-health-status-and-cognitive-abilities-the-role-of-cytokine-profile-and-systemic-inflammation
#14
Marta Sochocka, Maciej Sobczyński, Aleksandra Sender-Janeczek, Katarzyna Zwolińska, Olga Błachowicz, Tomasz Tomczyk, Marek Ziętek, Jerzy Leszek
BACKGROUND: Contemporary neurobiology, periodontal medicine, and immunology are now focusing on the relationship between chronic periodontitis and systemic diseases, that also include Alzheimer's disease (AD). However a causative relationship between dementia and periodontitis has yet to be confirmed. OBJECTIVE: The aim of the study was to determine whether periodontal health status and cognitive abilities are correlated with the relative changes in systemic measures of pro- and anti-inflammatory cytokines as a reflection of systemic inflammation...
March 16, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28315145/educational-intervention-on-undergraduate-cancer-awareness-and-self-directed-learning
#15
Lih-Lian Hwang
Traditional lecture-based learning (LBL) can increase cancer awareness in undergraduates. However, because of the rapidly changing knowledge base in medicine, undergraduates must develop skills required for lifelong self-directed learning (SDL). Problem-based learning (PBL) has been suggested as an SDL approach. This study used a nonequivalent control group with a pretest-posttest design for comparing PBL and LBL for their effectiveness in increasing cancer awareness and SDL among nonmedicine or nonnursing major undergraduates in a health-related general education course...
March 17, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28285165/effect-of-a-pbl-teaching-method-on-learning-about-nursing-care-for-patients-with-depression
#16
Marta Arrue, Begoña Ruiz de Alegría, Jagoba Zarandona, Itziar Hoyos Cillero
BACKGROUND: Depression is a worldwide public health problem that requires the attention of qualified health professionals. The training of skilled nurses is a challenge for nursing instructors due to the complexity of this pathology. OBJECTIVES: The aim was to analyse the declarative and argumentative knowledge acquired about depression by students receiving traditional expository instruction versus students receiving problem-based learning instruction. METHODS: Quasi-experimental study with pre-test and post-test design in experimental and control group to measure differences in the improvement of declarative and argumentative knowledge...
February 27, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28283953/the-effects-of-agaricus-blazei-murill-polysaccharides-on-cadmium-induced-apoptosis-and-the-tlr4-signaling-pathway-of-peripheral-blood-lymphocytes-in-chicken
#17
Wenjing Liu, Ming Ge, Xuequan Hu, Ai Lv, Dexing Ma, Xiaodan Huang, Ruili Zhang
In this study, we investigated the effects of Agaricus blazei Murill polysaccharides (ABP) on cadmium (Cd)-induced apoptosis and the TLR4 signaling pathway of chicken peripheral blood lymphocytes (PBLs). Seven-day-old healthy chickens were randomly divided into four groups, and each group contained 20 males. The cadmium-supplemented diet group (Cd group) was fed daily with full feed that contained 140 mg cadmium chloride (CdCl2)/kg and 0.2 mL saline. The A. blazei Murill polysaccharide diet group (ABP group) was fed daily with full feed with 0...
March 10, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28282548/attenuated-in-vitro-effects-of-ifn-%C3%AE-il-2-and-il-12-on-functional-and-receptor-characteristics-of-peripheral-blood-lymphocytes-in-metastatic-melanoma-patients
#18
Katarina M Mirjačić Martinović, Ana M Vuletić, Nada Lj Babović, Radan R Džodić, Gordana M Konjević, Vladimir B Jurišić
Considering tumor-induced suppression of lymphocytes the aim of this study was to investigate in vitro effects of IFN-α, IL-2, IL-12 and IL-18 as immunomodulating agents on the functional and receptor characteristics of peripheral blood lymphocytes (PBL) in metastatic melanoma (MM) patients compared to healthy controls (HC). In HC IFN-α, IL-2 and IL-12 enhanced mRNA level of perforin by inducing pSTAT-1 and pSTAT-5 signaling molecules. Additionally, the expression of NKG2D activating receptor and its DAP10 signaling molecule was upregulated by IL-2...
March 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28281516/-features-of-a-necrotic-and-inflammatory-process-in-different-forms-of-nonalcoholic-fatty-liver-disease
#19
I V Kurbatova, O P Dudanova
AIM: To identify the features of development of a necrotic and inflammatory process in different forms of nonalcoholic fatty liver disease (NAFLD), by comparatively analyzing a full set of clinical and laboratory parameters, including the cytokine status and the expression level of enzyme genes controlling the apoptosis of peripheral leukocytes. SUBJECTS AND METHODS: 86 patients with NAFLD, including 8 (9.3%) with hepatic steatosis (HS), 70 (81.4%) with nonalcoholic steatohepatitis (NASH), 40, 19, and 11 with mild, moderate, and high disease activity, respectively, and 8 (9...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28260650/characterizations-of-cd4-1-cd4-2-and-cd8%C3%AE-t-cell-subpopulations-in-peripheral-blood-leucocytes-spleen-and-head-kidney-of-japanese-flounder-paralichthys-olivaceus
#20
Jing Xing, Junjie Ma, Xiaoqian Tang, Xiuzhen Sheng, Wenbin Zhan
In the previous study, antibodies against CD3 molecule have been produced and were used in labeling T cells in Japanese flounder (Paralichthys olivaceus). In this paper, CD4(+) and CD8(+) lymphocytes subpopulations in peripheral blood leucocytes (PBL), spleen and head kidney of flounder were investigated. The flounder CD4-1, CD4-2 and CD8β recombinant proteins and their antibodies (Abs) were produced, then the cross-reactivity of the Abs to CD4-1, CD4-2 and CD8β was detected by Western blotting, respectively, and the reactions of Abs to PBL were analyzed by immunofluorescence staining (IFS) and flow cytometry (FCM)...
March 2, 2017: Molecular Immunology
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