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Ascites consistency

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https://www.readbyqxmd.com/read/29907790/comparison-of-two-protocols-of-carbon-tetrachloride-induced-cirrhosis-in-rats-improving-yield-and-reproducibility
#1
José I Fortea, Carolina Fernández-Mena, Marta Puerto, Cristina Ripoll, Jorge Almagro, Juan Bañares, José M Bellón, Rafael Bañares, Javier Vaquero
Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models of cirrhosis induced by orogastric administration of CCl4 once (CCl4-1xWk) or twice a week (CCl4-2xWk) for 12 weeks in male Sprague-Dawley rats. Control rats received water instead of CCl4. Both CCl4 protocols similarly attenuated body weight gain (p < 0.01 vs. Control). Although both CCl4 protocols increased hepatic fibrosis, portal hypertension and splenomegaly, the magnitude of these alterations was higher and more consistent in CCl4-2xWk rats...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29889749/clinical-variables-associated-with-adverse-maternal-outcomes-in-puerperal-group-a-streptococci-infection
#2
Jennifer E Kaiser, Amanda V Bakian, Robert M Silver, Erin A S Clark
OBJECTIVE: To identify clinical variables associated with increased risk of composite adverse outcome in a cohort of women with puerperal group A streptococci infection. METHODS: Our prospective case registry enrolled patients between 1991 and 2017. Chart abstraction was conducted for admission demographic and clinical data in patients with culture-proven puerperal group A streptococci infection. We created a composite variable of signs of capillary leakage including pulmonary edema, pleural effusion, ascites, and abdominal distention...
June 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29804074/metastatic-ductal-carcinoma-of-the-breast-to-colonic-mucosa
#3
Angela E Schellenberg, Melissa Lillian Wood, Nick Baniak, Paul Hayes
Breast cancer is the most common malignancy among women, while invasive ductal carcinoma is the most common type of invasive breast cancer. Metastatic spread to the colon and rectum in breast cancer is rare. This report describes a case of a 69-year-old woman with metastatic ductal breast cancer to the rectosigmoid, presenting as an incidental finding on screening colonoscopy. The breast carcinoma was first diagnosed 2 years prior. Colonic biopsies from colonoscopy confirmed metastatic adenocarcinoma consistent with a breast primary...
May 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29803752/a-novel-ultrasonographic-scoring-system-of-sinusoidal-obstruction-syndrome-after-hematopoietic-stem-cell-transplantation
#4
Mutsumi Nishida, Kaoru Kahata, Eiko Hayase, Akio Shigematsu, Megumi Sato, Yusuke Kudo, Satomi Omotehara, Takahito Iwai, Junichi Sugita, Hitoshi Shibuya, Chikara Shimizu, Takanori Teshima
BACKGROUND: Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a well-documented complication after hematopoietic stem cell transplantation (HSCT). Transabdominal ultrasonography (US) enables to visualize blood flow abnormalities and is therefore useful for the diagnosis of SOS/VOD. We herein prospectively evaluated accuracy of a novel ultrasonographic diagnostic scoring system of SOS/VOD based on US findings. METHODS: We carried out US in 106 patients on day 14 and when SOS/VOD was suspected after allogeneic HSCT...
May 24, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29797793/next-generation-sequencing-unravels-extensive-genetic-alteration-in-recurrent-ovarian-cancer-and-unique-genetic-changes-in-drug-resistant-recurrent-ovarian-cancer
#5
Zhen-Hua Du, Fang-Fang Bi, Lei Wang, Qing Yang
BACKGROUND: By using a high-throughput sequencing technique, we sought to delineate genetic alterations in recurrent ovarian cancer patients and further compare genetic changes in drug-resistant and -sensitive recurrent ovarian cancer patients. We also sought to study the specificity, sensitivity, and consistency of DNA biomarkers in liquid biopsy specimens and ovarian cancer tissue DNA. METHODS: Tumor tissue specimens and blood samples were obtained from pathologically proven recurrent ovarian cancer patients...
May 24, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29754978/risk-stratification-using-a-novel-liver-functional-reserve-score-of-combination-prothrombin-time-international-normalized-ratio-to-albumin-ratio-and-albumin-in-patients-with-hepatocellular-carcinoma
#6
Koichiro Haruki, Hiroaki Shiba, Nobuhiro Saito, Takashi Horiuchi, Yoshihiro Shirai, Yuki Fujiwara, Kenei Furukawa, Taro Sakamoto, Katsuhiko Yanaga
BACKGROUND: Liver function in patients with hepatocellular carcinoma is generally graded according to the Child-Pugh system; however, some variables in the Child-Pugh grade are subjective. We developed a novel, objective score called the prothrombin time-international normalized ratio to albumin ratio. The aim of this study was to evaluate the prognostic value of this new score in patients with hepatocellular carcinoma after hepatic resection. METHODS: The study comprised 199 patients who underwent elective hepatic resection for hepatocellular carcinoma between January 2003 and December 2014...
May 10, 2018: Surgery
https://www.readbyqxmd.com/read/29742811/primary-sclerosing-cholangitis-risk-estimate-tool-presto-predicts-outcomes-in-psc-a-derivation-validation-study-using-machine-learning
#7
John E Eaton, Mette Vesterhus, Bryan M McCauley, Elizabeth J Atkinson, Erik M Schlicht, Brian D Juran, Andrea A Gossard, Nicholas F LaRusso, Gregory J Gores, Tom H Karlsen, Konstantinos N Lazaridis
BACKGROUND & AIMS: Improved methods are needed to risk stratify and predict outcomes in patients with primary sclerosing cholangitis (PSC). Therefore, we sought to derive and validate a new prediction model and compare its performance to existing surrogate markers. METHODS: The model was derived using 509 subjects from a multicenter North American cohort and validated in an international multicenter cohort (n=278). Gradient boosting, a machine based learning technique, was used to create the model...
May 9, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29736145/functional-activity-of-natural-killer-cells-in-biological-fluids-in-patients-with-colorectal-and-ovarian-cancers
#8
Natalia V Yunusova, Marina N Stakheyeva, Sergey V Molchanov, Sergey G Afanas'ev, Anastasia A Tsydenova, Larisa A Kolomiets, Nadejda V Cherdyntseva
Aim of the study: To compare the functional activity of natural killer cells depending on the presence of a malignant process and its dissemination. Material and methods: The study included 20 patients with Stage IIIB, C (FIGO, 2009) ovarian cancer, 10 patients with benign ovarian tumours (BOT), and 20 patients with colorectal cancer (T2-4N0-2M0). The control group consisted of 9 healthy donors. To evaluate the number and functional activity of NK cells, multicolour flow cytometry was performed...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29708273/a-case-of-feline-gastrointestinal-eosinophilic-sclerosing-fibroplasia-limited-to-the-mesentery
#9
N Kambe, R Okabe, H Osada, M Ogawa, M Kishimoto, R Fukushima, H Kondo, K Ohmori
An entire, female, mixed-breed cat of unknown age was presented with a 6-week history of lethargy, anorexia and vomiting. There was an increase in the number of white blood cells in the blood, including neutrophils and eosinophils; moderate anaemia; ascites; and possible mesenteric peritonitis. Exploratory laparotomy revealed firm, multifocal small nodules in the mesentery. As the nodules were surgically unresectable, they were biopsied. Histologically, the nodules were composed of thin trabeculae of dense collagen fibres mixed with plump fibroblasts and numerous eosinophils, consistent with feline gastrointestinal eosinophilic sclerosing fibroplasia...
April 30, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29702119/glomeruloid-hemangioma-associated-with-tafro-syndrome
#10
Aya Shinozaki-Ushiku, Takaaki Higashihara, Masako Ikemura, Junichiro Sato, Masaomi Nangaku, Tetsuo Ushiku, Masashi Fukayama
Glomeruloid hemangioma is a rare cutaneous lesion which has been considered as a specific cutaneous marker of POEMS syndrome. Herein, we present the first case of glomeruloid hemangioma associated with TAFRO syndrome, a unique variant of idiopathic multicentric Castleman's disease (iMCD). The patient is a 74-year-old female presented with fever, cervical lymphadenopathy, thrombocytopenia, bilateral pleural effusions and ascites. Biopsy of the lymph node revealed MCD-like histology and bone marrow biopsy showed mild reticulin fibrosis, consistent with TAFRO syndrome...
April 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29690960/is-hepatovenocaval-syndrome-a-different-entity-from-budd-chiari-syndrome-in-children
#11
Nadia Waheed, Huma Arshad Cheema, Hassan Suleman, Iqra Mushtaq, Zafar Fayyaz, Nadeem Anjum
OBJECTIVE: To differentiate between clinical and demographic spectrum, and outcome in hepatovenocaval syndrome (HVCS) and Budd-Chiari syndrome (BCS). STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children Hospital, Lahore, from January 2014 to January 2017. METHODOLOGY: All children less than 18 years of age, presenting with ascites and visible veins over abdomen, flanks and back were enrolled in the study...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29688031/gynecologic-serous-carcinoma-an-immunohistochemical-analysis-of-malignant-body-fluid-specimens
#12
Shuyue Ren, William Klump
CONTEXT: - Evaluation of fluid specimens involved by serous carcinoma might potentially include PAX8, GATA3, Uroplakin II, SOX2, and SALL4 antibodies. Those markers are commonly employed for diagnosing carcinomas of various types, including urothelial malignancies and germ cell tumors. There have been no comprehensive immunohistochemical studies, to our knowledge, for those markers on fluid specimens involved by serous carcinoma. OBJECTIVE: - To evaluate immunohistochemical markers PAX8, GATA3, SOX2, uroplakin II, and SALL4 in the diagnosis of high-grade serous carcinoma in fluid specimens...
April 24, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29673407/hypercalcemia-as-a-rare-presentation-of-angioimmunoblastic-t-cell-lymphoma-a-case-report
#13
Sana Chams, Inaya Hajj Hussein, Skye El Sayegh, Nour Chams, Khalid Zakaria
BACKGROUND: Angioimmunoblastic T cell lymphoma is a rare malignancy, accounting for only 2% of all non-Hodgkin lymphomas, first described in the 1970s and subsequently accepted as a distinct entity in the current World Health Organization classification. Due to the paucity of this disease, there is still no identifiable etiology, no consistent risk factors, and the pathogenesis remains unclear. CASE PRESENTATION: An 83-year-old Caucasian man presented to an emergency department with palpitations and was found to have atrial fibrillation...
April 20, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29666076/histoplasma-meets-crohn-s-disease-a-rare-case-of-new-onset-ascites
#14
Charles Robert Bosshardt, John Gnann, Nilesh Lodhia
A 53-year-old man with Crohn's disease treated with adalimumab was hospitalised with abdominal pain, fatigue, fever and chills. CT scan of the abdomen showed chronic thickening of the terminal ileum and cecum and new-onset ascites. Further studies revealed weakly positive urine and serum histoplasma antigen. Laparoscopy revealed metastatic caking of the omentum and abdominal wall; peritoneal biopsy demonstrated organisms morphologically consistent with Histoplasma capsulatum No dissemination outside of the peritoneal cavity was evident...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29665849/an-innovative-immunotherapeutic-strategy-for-ovarian-cancer-clec10a-and-glycomimetic-peptides
#15
Laura L Eggink, Katherine F Roby, Robert Cote, J Kenneth Hoober
BACKGROUND: Receptors specific for the sugar N-acetylgalactosamine (GalNAc) include the human type II, C-type lectin receptor macrophage galactose-type lectin/C-type lectin receptor family member 10A (MGL/CLEC10A/CD301) that is expressed prominently by human peripheral immature dendritic cells, dendritic cells in the skin, alternatively-activated (M2a) macrophages, and to lesser extents by several other types of tissues. CLEC10A is an endocytic receptor on antigen-presenting cells and has been proposed to play an important role in maturation of dendritic cells and initiation of an immune response...
April 17, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29644160/wilson-s-disease-expect-the-unexpected
#16
Talal El Imad, Hassan Al Moussawi, Fady G Haddad, Richard Felix, Stephen M Mulrooney
A 64-year-old woman, presented with abdominal distention, jaundice and resting tremor, was found to have liver injury and abnormal liver enzymes. A computed tomography (CT) scan of the abdomen and pelvis showed abdominopelvic ascites and signs of liver cirrhosis. An extensive liver disease workup was performed and came back negative; therefore, a liver biopsy was obtained and showed evidence of cirrhosis with elevated liver copper consistent with Wilson's disease (WD). We report a unique case of late-onset WD in which the ceruloplasmin level and 24-h urinary copper excretion were all normal...
February 8, 2018: Curēus
https://www.readbyqxmd.com/read/29589379/results-and-factors-associated-with-adverse-outcome-after-tricuspid-valve-replacement
#17
Paweł Litwiński, Piotr Kołsut, Tadeusz Sitko, Tomasz Zieliński, Piotr Hoffman, Tomasz Hryniewiecki, Jacek Różański, Mariusz Kuśmierczyk
BACKGROUND AND AIM: This retrospective analysis of patients with severe tricuspid valve disease, who underwent tricuspid valve replacement (TVR) for either tricuspid regurgitation or stenosis, has been designed to determine the factors that predict poor hospital and long-term survival. METHODS: The study population comprised 86 patients, 65 women and 21 men, who underwent TVR with or without con-comitant surgical procedures between 2000 and 2010 at our institution...
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29581035/validation-of-the-edmonton-symptom-assessment-system-ascites-modification
#18
Masanori Mori, Tatsuya Morita, Naosuke Yokomichi, Akihiro Nitto, Naoko Takahashi, Shingo Miyamoto, Hiroyuki Nishie, Junji Matsuoka, Hiroki Sakurai, Tatsuhiko Ishihara, Yoko Tarumi, Asao Ogawa
CONTEXT: Few patient-reported outcomes are available to measure the symptoms associated with malignant-related ascites in patient care and clinical research. Although the Edmonton Symptom Assessment System: Ascites Modification (ESAS:AM) is a brief tool to measure symptoms associated with malignant-related ascites, it remains to be fully validated. OBJECTIVES: The objective of the study was to validate the ESAS:AM in Japanese cancer patients. METHODS: We assessed the internal consistency, test-retest reliability, concurrent validity, and construct validity in 292 Japanese adult patients with cancer...
June 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29577037/chylous-ascites-a-review-of-pathogenesis-diagnosis-and-treatment
#19
REVIEW
Richa Bhardwaj, Haleh Vaziri, Arun Gautam, Enrique Ballesteros, David Karimeddini, George Y Wu
Chylous ascites (CA) is a rare form of ascites that results from the leakage of lipid-rich lymph into the peritoneal cavity. This usually occurs due to trauma and rupture of the lymphatics or increased peritoneal lymphatic pressure secondary to obstruction. The underlying etiologies for CA have been classified as traumatic, congenital, infectious, neoplastic, postoperative, cirrhotic or cardiogenic. Since malignancy and cirrhosis account for about two-thirds of all the cases of CA in Western countries, in this article we have attempted to reclassify CA based on portal and non-portal etiologies...
March 28, 2018: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29554705/ascites-and-encapsulating-peritonitis-in-endometriosis-a-systematic-review-with-a-case-report
#20
Thais Fontes de Magalhães, Kathiane Lustosa Augusto, Livia Ponte Mota, Arthur Ribeiro da Costa, Rainardo Antonio Puster, Leonardo Robson Pinheiro Sobreira Bezerra
Endometriosis can have several different presentations, including overt ascites and peritonitis; increased awareness can improve diagnostic accuracy and patient outcomes. We aim to provide a systematic review and report a case of endometriosis with this unusual clinical presentation. The PubMed/MEDLINE database was systematically reviewed until October 2016. Women with histologically-proven endometriosis presenting with clinically significant ascites and/or frozen abdomen and/or encapsulating peritonitis were included; those with potentially confounding conditions were excluded...
March 2018: Revista Brasileira de Ginecologia e Obstetrícia
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