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Dalia M Kabary, Maged W Helmy, Kadria A Elkhodairy, Jia-You Fang, Ahmed O Elzoghby
The self-tumor targeting polymers, lactoferrin (LF) and hyaluronic acid (HA) were utilized to develop layer-by-layer (LbL) lipid nanoparticles (NPs) for dual delivery of berberine (BER) and rapamycin (RAP) to lung cancer. To control its release from the NPs, BER was hydrophobically ion paired with SLS prior to incorporation into NPs. Spherical HA/LF-LbL-RAP-BER/SLS-NPs 250.5 nm in diameter, with a surface charge of -18.5 mV were successfully elaborated. The NPs exhibited sequential release pattern with faster release of BER followed by controlled release of RAP which enables sensitization of lung tumor cells to the anti-cancer action of RAP...
May 15, 2018: Colloids and Surfaces. B, Biointerfaces
Lei Li, Xiao Li, Xin Huang, Weilai Jiang, Letian Liu, Chunning Hou, Yanqing Yang, Lei Zhang, Xiaodan Zhang, Longwei Ye, Jie Yuan, Guolin Li, Haiming Sun, Limin Mao
We introduced polyethyleneimine-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miRNA122 (miR-122) for the treatment of oral squamous cell carcinoma. BER was stabilized by incorporating PC to form ber -PC. Ber -PC was further electrostatically complexed with miR-122 to yield mr-ber- PC for the co-delivery of BER and miR-122. mr-ber- PC treatment dramatically decreased the level of invasion and migration of oral squamous cell carcinoma cells compared with single drug treatments. This study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anti-cancer drug BER and miR-122 to significantly increase the anti-cancer therapeutic effects...
May 16, 2018: Bioscience Reports
Ruibing An, Zhanni Gu, Haifeng Sun, Yuxuan Hu, Runqi Yan, Deju Ye, Hong Liu
Selective imaging and inducing mitochondrial dysfunction in tumor cells using mitochondria-targeting probes has become as a promising approach for cancer diagnosis and therapy. Here, we report the design of a fluorescent berberine analog, dehydroberberine (DH-BBR), as a new mitochondria-targeting probe capable of self-assembling into monodisperse organic nanoparticles (DTNPs) upon integration with a lipophilic counter anion, allowing for enhanced fluorescence imaging and treatment of tumors in living mice. X-ray crystallography revealed that the self-assembly process was attributed to a synergy of different molecular interactions, including π-π stacking, O···π interaction and electrostatic interaction between DH-BBR and counter anions...
May 15, 2018: Chemistry: a European Journal
Sungyun Kim, Song Yi Lee, Hyun-Jong Cho
Organic/inorganic hydrid nanoparticles (NPs) composed of berberine (BER) and zinc oxide (ZnO) were developed for the therapy of lung cancers. Without the use of pharmaceutical excipients, NPs were fabricated with only dual anticancer agents (BER and ZnO) by facile blending method. The mean weight ratio between BER and ZnO in BER-ZnO NPs was 39:61 in this study. BER-ZnO NPs dispersed in water exhibited 200-300 nm hydrodynamic size under 5 mg/mL concentration. The exposure of both BER and ZnO in the outer layers of BER-ZnO NPs was identified by X-ray photoelectron spectroscopy analysis...
May 11, 2018: Biochemical and Biophysical Research Communications
Estrella Rubio-Solsona, Salvador Martí, Juan J Vílchez, Francesc Palau, Janet Hoenicka
Ankyrin repeat and kinase domain containing 1 (ANKK1) gene has been widely related to neuropsychiatry disorders. The localization of ANKK1 in neural progenitors and its correlation with the cell cycle has suggested its participation in development. However, ANKK1 functions still need to be identified. Here, we have further characterized the ANKK1 localization in vivo and in vitro, by using immunolabeling, quantitative real-time PCR and Western blot in the myogenic lineage. Histologic investigations in mice and humans revealed that ANKK1 is expressed in precursors of embryonic and adult muscles...
2018: PloS One
Li Liu, Ning Luo, Jing Guo, Yan Xie, Li Chen, Zhongping Cheng
Adenomyosis is a common chronic gynecological disorder with some tumor-like properties, including aberrant proliferation, invasion and migration. Berberine (BBR) is an isoquinoline derivative alkaloid with diverse pharmacological activities for the treatment of a wide variety of diseases. However, the effect of BBR on adenomyosis has not been understood. This study was to evaluate the potential therapeutic effect of BBR on ectopic endometrial stromal cells (EESCs) isolated from patients with adenomyosis. Our data showed that BBR significantly inhibited the proliferation and viability of eutopic endometrial stromal cells (EuESCs) and EESCs, while slightly affected the growth of normal endometrial stromal cells (NESCs)...
December 8, 2017: Journal of Pharmacological Sciences
Jigang Wang, Yin-Kwan Wong, Fulong Liao
The field of Traditional Chinese Medicine (TCM) represents a vast and largely untapped resource for modern medicine. Exemplified by the success of the antimalarial artemisinin, the recent years have seen a rapid increase in the understanding and application of TCM-derived herbs and formulations for evidence-based therapy. In this review, we summarise and discuss the developmental history, clinical background and molecular basis of an action for several representative TCM-derived medicines, including artemisinin, arsenic trioxide, berberine and Salvia miltiorrhiza or Danshen...
May 11, 2018: Expert Reviews in Molecular Medicine
Juan Feng, Haoxun Li, Wenlong Zhao, Honglei Dang, Ruijun Wang, Kun Luo, Hongyan Guo, Wanli Xing, Jing Cheng, Weifang Song, Yimin Sun, Lan Xie
Rhizoma Coptidis is a widely cultivated traditional Chinese herb. Although the chemical profiles of Rhizoma Coptidis have been established previously, the biological profiling of Rhizoma Coptidis has not been conducted yet. In this study, we collected Rhizoma Coptidis varieties from four distinct growing regions and performed genome-wide biological response fingerprinting (BioReF) on HepG2 cells using a gene expression array. Similar biological pathways were affected by extracts of all four Rhizoma Coptidis varieties but not by their analogue, Mahoniae Caulis...
May 11, 2018: Molecular Pharmaceutics
Keqin Xu, Gongxiu He, Jieming Qin, Xuexiang Cheng, Hanjie He, Dangquan Zhang, Wanxi Peng
There are three key medicinal components (phellodendrine, berberine and palmatine) in the extracts of Phellodendron bark, as one of the fundamental herbs of traditional Chinese medicine. Different extraction methods and solvent combinations were investigated to obtain the optimal technologies for high-efficient extraction of these medicinal components. RESULTS: The results showed that combined solvents have higher extracting effect of phellodendrine, berberine and palmatine than single solvent, and the effect of ultrasonic extraction is distinctly better than those of distillation and soxhlet extraction...
May 2018: Saudi Journal of Biological Sciences
Xiaorui Lin, Nan Zhang
Berberine, an isoquinoline alkaloid, is demonstrated to have a variety of pharmacologic effects. Widely used as nonprescription drug for diarrhea, berberine has also broadened its applications in therapies of cardiovascular diseases, diabetes mellitus, tumor, and so forth. However, researches about berberine's protective effects on nervous system are still so insufficient that clinical uses cannot popularize and underlying molecules mechanisms are confused and incomplete. Well-known pathways such as Pl3K/Akt/Bcl-2 pathway, Nrf2/HO-1 pathway, and MAPK signaling pathway help berberine to protect neurons through antiapoptotic, antioxidative, and anti-inflammatory activities...
May 6, 2018: Phytotherapy Research: PTR
Wuli Zhao, Hong Liu, Junxia Wang, Mengyan Wang, Rongguang Shao
BACKGROUND: A35 is a novel synthetic cyclizing-berberine recently patented as an antitumor compound. Based on its dual targeting topoisomerase (top) activity, A35 might overcome the resistance of single-target top inhibitors and has no cardiac toxicity for not targeting top2β. In this study we further explored the biological effects and mechanisms of A35. METHODS: Antitumor activity of A35 was evaluated by SRB and colony formation assay. G2/M phase arrest (especially M) and first damage of M-phase cells were investigated by flow cytometry, cytogenetic analysis, immunofluorescence, co-immunoprecipitation and WB...
May 4, 2018: Journal of Experimental & Clinical Cancer Research: CR
Jie Li, Fang Liu, Shulong Jiang, Jie Liu, Xiuhong Chen, Shangnuan Zhang, Haibo Zhao
Berberine, also known as berberine hydrochloride and isoquinoline alkaloid, is a major alkaloid from Coptis chinensis . Berberine's extensive biological properties have previously been studied, and it has been used clinically for the treatment of diarrhea, hypertension, diabetes and other diseases. The present study aimed to determine the possible anticancer effects of berberine hydrochloride treatment on human non-small cell lung cancer (NSCLC) cell proliferation and apoptosis via the matrix metalloproteinase 2 (MMP-2) and the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax) signaling pathway...
May 2018: Oncology Letters
Yonghwa Lee, Lichao Liu, Yongsub Yi
Berberine has abundant beneficial properties including anti-cancer effects. In the present study, we examined the inhibitory effect of berberine on α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis in B16F1 melanoma cells. The results showed that berberine decreased the expression of tyrosinase and microphthalmia-associated transcription factor (MITF) in a dose-dependent manner. In order to observe the potential target for the inhibitory effect of berberine, we examined the effect of berberine on TRP-1 and TRP-2...
May 1, 2018: Die Pharmazie
Yi-Ran Wang, Yong-Hui Li, Tao Guo, Hai-Long Li, Yin-Feng Tan, Zhong Zhang, Xu-Guang Zhang, Shi-Ying Mai, Jun-Qing Zhang
The compounds of N-Methylanhydrotetrahydroberberrubine A, dictamnine and eudesmin were the primary bioactive components in the roots of Zanthoxylum armatum DC (Z. armatum). To clarify the pharmacokinetics and distribution of these three compounds, an ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) was employed to determine the contents of these three compounds in rat plasma and seven tissues. The separation was achieved on a Kinetex XB-C18 100A column (2.1 × 50 mm, 2.6 μm, Phenomenex)...
April 26, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Hong Jiang, Dingkun Zhang, Jing He, Xue Han, Junzhi Lin, Yang Lan, Xi Xiong, Lingying Yu, Ming Yang, Li Han
Background: Berberine hydrochloride (BH) is widely used as a nonprescription drug to treat diarrhea without drug resistance and side effects worldwide. However, its drastic bitterness affects patient compliance severely. Hence, it is essential to mask the bitter taste of BH. Objective: Powder surface modification technology is attempted to mask the bitterness of BH through changing the surface properties in vibromill. The purpose of this study was to apply this technology to mask the bitterness of BH and improve the patient compliance...
April 2018: Pharmacognosy Magazine
Wei Zhuang, Ting Li, Caiji Wang, Xi Shi, Yalan Li, Shili Zhang, Zeqi Zhao, Hongyan Dong, Yuehua Qiao
Cytomegalovirus (CMV) is the leading cause of sensorineural hearing loss (SNHL) in children because of its damage to the cochlea and spiral ganglion cells. Therefore, it has become a top priority to devise new methods to effectively protect spiral ganglion cells from damage. Berberine (BBR) has gained attention for its vast beneficial biological effects through immunomodulation, and its anti-inflammatory and anti-apoptosis properties. However, the effect of BBR on spiral ganglion cells and molecular mechanisms are still unclear...
April 28, 2018: Free Radical Biology & Medicine
Maria-Ioanna Christodoulou, Job Tchoumtchoua, Alexios-Leandros Skaltsounis, Andreas Scorilas, Maria Halabalaki
BACKGROUND: Accumulating experimental data support the capacity of natural compounds to intervene in complicated molecular pathways underlying the pathogenesis of certain human morbidities. Among them, diabetes is now a world's epidemic associated with increased risk of death; thus, the detection of novel anti-diabetic agents and/or adjuvants is of vital importance. Alkaloids represent a diverse group of natural products with a range of therapeutic properties; during the last 20 years published research on their anti-diabetic capacity has been tremendously increased...
April 30, 2018: Current Medicinal Chemistry
Sylwia Zielińska, Anna Jezierska-Domaradzka, Magdalena Wójciak-Kosior, Ireneusz Sowa, Adam Junka, Adam M Matkowski
As antique as Dioscorides era are the first records on using Chelidonium as a remedy to several sicknesses. Inspired by the " signatura rerum " principle and an apparent ancient folk tradition, various indications were given, such as anti-jaundice and cholagogue, pain-relieving, and quite often mentioned-ophthalmological problems. Central and Eastern European folk medicine has always been using this herb extensively. In this region, the plant is known under many unique vernacular names, especially in Slavonic languages, associated or not with old Greek relation to "chelidon"-the swallow...
2018: Frontiers in Pharmacology
Chung-Ping Yu, Ching-Ya Huang, Shiuan-Pey Lin, Yu-Chi Hou
Coptidis Rhizoma (CR), the rhizome of Coptis chinensis FRANCH, is a popular Chinese herb. CR contains plenty of isoquinoline alkaloids such as berberine, coptisine and palmatine. Cyclosporine (CSP), an important immunosuppressant with narrow therapeutic window, is employed as a probe substrate of P-glycoprotein (P-gp) and CYP3A4 in order to investigate the in vivo modulation effect of CR on P-gp and CYP3A4. Three groups of rats were orally administered CSP without and with single dose or repeated dosing of CR in a parallel design...
April 2018: Journal of Food and Drug Analysis
F Xu, J Yang, B Meng, J W Zheng, Q Liao, J P Chen, X W Chen
Objective: To explore the effect of berberine on chronic inflammatory pain and the comorbid depression and the associated mechanisms. Methods: Forty healthy male ICR mice (2 months, 25-30 g) were used in the present study. The chronic inflammatory pain was induced by intraplantar injection of complete freund's adjuvant (CFA) to the hind paws. All animals were divided into 4 groups ( n =10 for each group) according to random number table: the saline group (group A), the chronic pain group (group B), the saline+ berberine group (group C) and the chronic pain+ berberine group (group D)...
April 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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