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https://www.readbyqxmd.com/read/28812548/bacteroidales-recruit-il-6-producing-intraepithelial-lymphocytes-in-the-colon-to-promote-barrier-integrity
#1
K A Kuhn, H M Schulz, E H Regner, E L Severs, J D Hendrickson, G Mehta, A K Whitney, D Ir, N Ohri, C E Robertson, D N Frank, E L Campbell, S P Colgan
Interactions between the microbiota and distal gut are important for the maintenance of a healthy intestinal barrier; dysbiosis of intestinal microbial communities has emerged as a likely contributor to diseases that arise at the level of the mucosa. Intraepithelial lymphocytes (IELs) are positioned within the epithelial barrier, and in the small intestine they function to maintain epithelial homeostasis. We hypothesized that colon IELs promote epithelial barrier function through the expression of cytokines in response to interactions with commensal bacteria...
August 16, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28812292/effect-of-low-selenium-high-fat-diet-on-pig-peripheral-blood-lymphocytes-perspectives-from-selenoproteins-heat-shock-proteins-and-cytokines
#2
Tianqi Liu, Tianshu Yang, Tingru Pan, Ci Liu, Shu Li
The aim of the present study was to clarify the effect of low selenium (Se)/high fat on the mRNA expression of selenoproteins, heat shock proteins (HSPs) and cytokines in pig peripheral blood lymphocytes. Forty crossbred boar piglets with healthy lean body weights of 10 kg were randomly divided into four treatment groups (group C, group L-Se, group H-fat, and group L-Se-H-fat) (n = 10/group) and fed with the corresponding diet for 16 weeks. The pig peripheral blood lymphocytes were extracted, and the mRNA expression of selenoproteins, HSPs, and cytokines was measured...
August 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28812210/increased-il-6-expression-on-thp-1-by-il-34-stimulation-up-regulated-rheumatoid-arthritis-th17-cells
#3
Bing Wang, Yawei Tang, Xiaotong Sun, Xunli Ouyang, Han Li, Jing Wei, Yan Zhang, Xia Li
IL-34 is a pleiotropic cytokine, which is a key regulator of monocytes/macrophages and might participate in the pathogenesis of RA. In this study, we aimed to explore the effect of IL-34 on the monocyte-like cell line THP-1 and the quantitative variation of Th17 cells in THP-1 and RA CD4(+)T cells coculture system. CD4(+)T cells were purified from RA PBMC using immunomagnetic beads. THP-1 were cultured with RA CD4(+)T cells. The frequency of Th17 cells was determined by FACS. Fluorscence indensity and expression of ROS were detected by FACS and cell staining, respectively...
August 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28811749/acute-cocoa-flavanols-intake-has-minimal-effects-on-exercise-induced-oxidative-stress-and-nitric-oxide-production-in-healthy-cyclists-a-randomized-controlled-trial
#4
Lieselot Decroix, Cajsa Tonoli, Danusa Dias Soares, Amandine Descat, Marie-José Drittij-Reijnders, Antje R Weseler, Aalt Bast, Wilhelm Stahl, Elsa Heyman, Romain Meeusen
BACKGROUND: Cocoa flavanols (CF) can stimulate vasodilation by improved nitric oxide (NO) synthesis and have antioxidant and anti-inflammatory capacities. This study aimed to examine whether acute CF intake can affect exercise-induced changes in antioxidant capacity, oxidative stress, inflammation and NO production, as well as exercise performance and recovery in well-trained cyclists. METHODS: Twelve well-trained male cyclists (mean ± SD age, VO2max: 30 ± 3 years, 63...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28811709/bone-marrow-derived-monocyte-infusion-improves-hepatic-fibrosis-by-decreasing-osteopontin-tgf-%C3%AE-1-il-13-and-oxidative-stress
#5
Veruska Cintia Alexandrino de Souza, Thiago Almeida Pereira, Valéria Wanderley Teixeira, Helotonio Carvalho, Maria Carolina Accioly Brelaz de Castro, Carolline Guimarães D'assunção, Andréia Ferreira de Barros, Camila Lima Carvalho, Virgínia Maria Barros de Lorena, Vláudia Maria Assis Costa, Álvaro Aguiar Coelho Teixeira, Regina Celia Bressan Queiroz Figueiredo, Sheilla Andrade de Oliveira
AIM: To evaluate the therapeutic effects of bone marrow-derived CD11b(+)CD14(+) monocytes in a murine model of chronic liver damage. METHODS: Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry, biochemical assessment, immunohistochemistry and enzyme-linked immunosorbent assay...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28811686/influence-of-the-flavonoid-quercetin-on-antioxidant-status-lipid-peroxidation-and-histopathological-changes-in-hyperammonemic-rats
#6
Sivamani Kanimozhi, Pakkiri Bhavani, Perumal Subramanian
We have studied the ability of quercetin (a bioflavonoid) in tackling oxidative stress to alleviate the symptoms during ammonium chloride-induced hyperammonemia. Hyperammonemia was induced by the treatment of ammonium chloride (AC) 100 mg/kg b.w for 56 days. Hyperammonemic rats exhibited reduced urea (in plasma) and increased ammonia (in blood), uric acid (in plasma), creatinine (in serum), oxidative stress markers (thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HP) and decreased levels of antioxidants (enzymatic and non-enzymatic) superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) in plasma and tissues (liver and brain) vitamins E and C (in plasma))...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28811678/patchoulene-epoxide-isolated-from-patchouli-oil-suppresses-acute-inflammation-through-inhibition-of-nf-%C3%AE%C2%BAb-and-downregulation-of-cox-2-inos
#7
Jia-Li Liang, Jia-Zhen Wu, Yu-Hong Liu, Zhen-Biao Zhang, Qi-Duan Wu, Han-Bin Chen, Yan-Feng Huang, Yao-Xing Dou, Jiang-Tao Zhou, Zi-Ren Su, Janis Ya-Xian Zhan
According to the GC-MS analysis, compositional variation was observed between samples of patchouli oil, of which an unknown compound identified as patchoulene epoxide (PAO) was found only in the long-stored oil, whose biological activity still remains unknown. Therefore, the present study aimed to evaluate the potential anti-inflammatory activity with three in vivo inflammatory models: xylene-induced ear edema, acetic acid-induced vascular permeability, and carrageenan-induced paw edema. Further investigation into its underlying mechanism on carrageenan-induced paw edema was conducted...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28811490/mammary-tumors-induce-central-pro-inflammatory-cytokine-expression-but-not-behavioral-deficits-in-balb-c-mice
#8
William H Walker Ii, Jeremy C Borniger, Surbhi, Abigail A Zalenski, Stevie L Muscarella, Julie A Fitzgerald, Ning Zhang, Monica M Gaudier-Diaz, A Courtney DeVries
Breast cancer survivors are more likely to develop mood disorders and cognitive deficits than women in the general population. Previous studies suggest that peripheral tumors elicit central pro-inflammatory cytokine production, in turn leading to depression and cognitive deficits. In the current study, two cohorts of female Balb/C mice received bilateral orthotopic injections of syngeneic 67NR, 4T07, or 4T1cells (1 × 10(5) cells per injection) to induce mammary tumors. Approximately three weeks later, learned fear (via fear conditioning) or depressive-like behavior (via tail suspension and forced swim test) was assessed...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811319/galectin-8-activates-dendritic-cells-and-stimulates-antigen-specific-immune-response-elicitation
#9
Julieta Carabelli, Valeria Quattrocchi, Alejandra D'Antuono, Patricia Zamorano, María Virginia Tribulatti, Oscar Campetella
Galectin-8 (Gal-8) is a mammalian β-galactoside-binding lectin, endowed with proinflammatory properties. Given its capacity to enhance antigen-specific immune responses in vivo, we investigated whether Gal-8 was also able to promote APC activation to sustain T cell activation after priming. Both endogenous [dendritic cells (DCs)] and bone marrow-derived DCs (BMDCs) treated with exogenous Gal-8 exhibited a mature phenotype characterized by increased MHC class II (MHCII), CD80, and CD86 surface expression. Moreover, Gal-8-treated BMDCs (Gal-8-BMDCs) stimulated antigen-specific T cells more efficiently than immature BMDCs (iBMDCs)...
August 15, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28811301/topically-applied-carvedilol-attenuates-solar-ultraviolet-radiation-induced-skin-carcinogenesis
#10
Kevin M Huang, Sherry Liang, Steven Yeung, Etuajie Oiyemhonlan, Kristan H Cleveland, Cyrus Parsa, Robert Orlando, Frank L Meyskens, Bradley Andresen, Ying Huang
In previous studies, the β-blocker carvedilol inhibited EGF-induced epidermal cell transformation and chemical carcinogen-induced mouse skin hyperplasia. As exposure to ultraviolet (UV) radiation leads to skin cancer, the present study examined whether carvedilol can prevent UV-induced carcinogenesis. Carvedilol absorbs UV like a sunscreen; thus, to separate pharmacological from sunscreen effects, 4-hydroxycarbazole (4-OHC), which absorbs UV to the same degree as carvedilol, served as control. JB6 P+ cells, an established epidermal model for studying tumor promotion, were used for evaluating the effect of carvedilol on UV-induced neoplastic transformation...
August 15, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28811129/microrna-29a-regulates-lipopolysaccharide-lps-induced-inflammatory-responses-in-murine-macrophages-through-the-akt1-nf-%C3%AE%C2%BAb-pathway
#11
Bufu Tang, Xingchen Li, Yanling Ren, Jing Wang, Di Xu, Yiru Hang, Tingting Zhou, Feng Li, Ling Wang
Akt activation in macrophages enhances lipopolysaccharide (LPS)-induced inflammatory responses through upregulation of the NF-κB signal pathway. Akt phosphorylation via microRNA (miR) caused the downregulation of Akt1. Here, we evaluated the role of miR-29a in LPS-triggered inflammatory responses. LPS stimulation of primary macrophages and RAW264.7 cells gradually increased the levels of miR-29a and was dependent on the LPS concentration. Overexpression of miR-29a in macrophages enhanced the expression of proinflammatory cytokines including IL-1β and IL-6, but not TNF-α...
August 12, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28810987/deployment-length-inflammatory-markers-and-ambulatory-blood-pressure-in-military-couples
#12
Stephanie Brooks Holliday, Amy DeSantis, Anne Germain, Daniel J Buysse, Karen A Matthews, Wendy M Troxel
INTRODUCTION: Changes in the frequency, duration, and nature of military deployments over the past 14 years have spurred efforts to understand the effects of deployment on the health of military service members and their spouses. However, few studies have examined the impact of deployments on health outcomes in both veterans and their partners. This study aims to examine the association between deployment length and health, including ambulatory blood pressure (BP) and stress-related markers of inflammation, in military veterans and their spouses...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810853/acute-effects-of-reducing-sitting-time-in-adolescents-a-randomized-cross-over-study
#13
Anisse Penning, Anthony D Okely, Stewart G Trost, Jo Salmon, Dylan P Cliff, Marijka Batterham, Steven Howard, Anne-Maree Parrish
BACKGROUND: Levels of sitting among adolescents are high, especially during the school day. The acute cognitive and health consequences associated with prolonged sitting are poorly understood in adolescents. This randomized crossover design study examined the acute effects of a simulated school day with reduced sitting or usual sitting on adolescents' cognitive function and cardiometabolic biomarkers. METHODS: Eighteen healthy school aged adolescents were recruited from the community to the study (11 males; 7 females; mean age [SD] = 13...
August 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28810847/fev1-and-fvc-and-systemic-inflammation-in-a-spinal-cord-injury-cohort
#14
Jaime E Hart, Rebekah Goldstein, Palak Walia, Merilee Teylan, Antonio Lazzari, Carlos G Tun, Eric Garshick
BACKGROUND: Systemic inflammation has been associated with reduced pulmonary function in individuals with and without chronic medical conditions. Individuals with chronic spinal cord injury (SCI) have clinical characteristics that promote systemic inflammation and also have reduced pulmonary function. We sought to assess the associations between biomarkers of systemic inflammation with pulmonary function in a chronic SCI cohort, adjusting for other potential confounding factors. METHODS: Participants (n = 311) provided a blood sample, completed a respiratory health questionnaire, and underwent spirometry...
August 15, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28810635/curcumin-protects-against-acute-renal-injury-by-suppressing-jak2-stat3-pathway-in-severe-acute-pancreatitis-in-rats
#15
Shuaijun Zhu, Chi Zhang, Qinyong Weng, Bing Ye
The aim of the present study was to investigate the effect of curcumin on acute renal injury in a rat model of severe acute pancreatitis (SAP). A SAP model with acute kidney injury was established in rats by retrograde injection of 5% sodium taurocholate into the pancreatic duct. The serum amylase, creatinine (Cr) and blood urea nitrogen (BUN) levels in rats were measured. Hematoxylin and eosin staining was used to assess pancreatic and renal histological changes. Serum tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels were measured using ELISA kits...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810626/expression-of-synovial-fluid-biomarkers-in-patients-with-knee-osteoarthritis-and-meniscus-injury
#16
Jian Ding, Xin Niu, Yan Su, Xiaolin Li
In the present study, the levels of synovial fluid biomarkers of patients with knee osteoarthritis (OA) and those with meniscus injury (MI) were compared to associate the levels of synovial fluid biomarkers with the degree of OA and MI. Synovial fluid samples were obtained from 51 cases with OA and 40 patients with MI. Severity of OA and MI were evaluated using the Kellgren-Lawrence (K-L) classification and Magnetic Resonance Imaging Osteoarthritis Knee Score, respectively. A comparative analysis of the levels of matrix metalloproteinase-13 (MMP-13), vascular endothelial growth factor (VEGF), interleukin (IL)-10, IL-8, IL-6, IL-1, tumor necrosis factor-α (TNF-α), as well as collagenase 2 in synovial fluid was made between patients with OA and MI...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810624/high-mobility-group-box-1-protein-attenuates-myocardial-ischemia-reperfusion-injury-via-inhibition-of-the-p38-mitogen-activated-protein-kinase-signaling-pathway
#17
Yan-Hong Zhou, Qian-Feng Han, Lan-Hua Wang, Tao Liu, Xiao-Yan Meng, Lei Wu, Tai Li, Yue-Ru Jiao, Heng-Chen Yao, De-Yong Zhang
The present study aimed to determine the effects of high mobility group box 1 protein (HMGB1) on myocardial ischemia reperfusion (I/R) injury in rats following acute myocardial ischemia and investigate the underlying molecular mechanisms of these effects. Male Wistar rats were randomly divided into the following groups (n=10/group): Sham operation; I/R; HMGB50 (50 ng/kg HMGB1 before I/R); HMGB100 (100 ng/kg HMGB1 before I/R); and HMGB200 (200 ng/kg HMGB1 before I/R). Serum cardiac troponin I (cTnI), interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels were subsequently measured...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810614/evolution-of-correlation-between-helicobacter-pylori-infection-and-autoimmune-liver-disease
#18
Xin-Guo Peng, Yu-Yuan Li, Hui-Ting Chen, Yan Zhou, Jian-Guo Ma, Hong-Min Yin
The present study was planned to evaluate correlation between Helicobacter pylori (HP) infection and autoimmune liver disease (AILD). A total of 60 patients diagnosed with AILD in Affiliated Hospital of Binzhou Medical College were continuously enrolled in the present study. HP infection was detected by 13C-urea breath test. The levels of anti-myeloperoxidase were tested by ELISA. The positive rate of anti-nuclear antibody (ANA), anti-mitochondrial antibody (AMA), anti-smooth muscle antibody (SMA) and anti-neutrophil cytoplasm antibody (ANCA) were tested by indirect immunofluorescence...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810608/mechanism-of-microrna-21-regulating-il-6-inflammatory-response-and-cell-autophagy-in-intervertebral-disc-degeneration
#19
Hao Lin, Wenzhi Zhang, Tao Zhou, Wansu Li, Ziao Chen, Chaochao Ji, Chao Zhang, Fang He
This study investigated the mechanism of microRNA-21 in regulating IL-6 inflammatory response and cell autophagy in intervertebral disc degeneration. A total of 10 patients with lumbar disc herniation accompanied by nerve root pain (observation group) and 10 patients with lumbar burst fractures (control group) were selected. The nucleus pulposus tissues of the lesion were obtained during operation for cell culture. Real-time quantitative polymerase chain reaction (PCR) was used to detect the expression of microRNA-21...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810601/comparative-study-of-dendritic-cells-matured-by-using-il-1%C3%AE-il-6-tnf-%C3%AE-and-prostaglandins-e2-for-different-time-span
#20
Xuejie Wu, Feng Xu, Jinliang Liu, Guiqiang Wang
Interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and prostaglandins E2 is considered as the standard cocktail for maturing dendritic cells (DCs). However, the appropriate time span for DC maturation with the standard cocktail remains unclear. The present study aimed to compare the differences between DCs matured with the standard cocktail for 24 and 48 h, respectively, and determine whether 24-h stimulation was sufficient for DC maturation. The findings demonstrated that, compared with DCs matured for 48 h, the levels of cluster of differentiation (CD)80, CD83, CD86 and programmed death-ligand 1 expression in DCs matured for 24 h were relatively lower...
August 2017: Experimental and Therapeutic Medicine
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