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https://www.readbyqxmd.com/read/29772444/functional-relevance-of-satb1-in-immune-regulation-and-tumorigenesis
#1
REVIEW
Krishna P Sunkara, Gaurav Gupta, Philip M Hansbro, Kamal Dua, Mary Bebawy
The Special AT-rich Sequence Binding Protein 1 (SATB1) is a chromatin organiser and transcription factor which regulates numerous cellular processes such as differentiation, proliferation and apoptosis through effects on gene expression. SATB1 undergoes various post-translational modifications, which determine its interaction with co-activators and co-repressors to induce regulation of gene transcription. SATB1 is an identified oncogene, its increased expression is associated with poor prognosis in many cancers...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29764509/ultrasound-guided-fine-needle-aspiration-of-retropharyngeal-lymph-nodes-after-radiotherapy-for-nasopharyngeal-carcinoma-a-novel-technique-for-accurate-diagnosis
#2
Long-Jun He, Chuanbo Xie, Yin Li, Lin-Na Luo, Ke Pan, Xiao-Yan Gao, Li-Zhi Liu, Jian-Ming Gao, Guang-Yu Luo, Hong-Bo Shan, Ming-Yuan Chen, Chong Zhao, Wei-Jun Fan, Ping Yang, Guo-Liang Xu, Jian-Jun Li
BACKGROUND: Enlarged retropharyngeal lymph nodes (RLNs) are very common in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. The most suitable treatment option for enlarged RLNs depends on the pathological results. However, RLN sampling is difficult and imminent in the clinic setting. We recently developed a novel minimally invasive technique termed endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for sampling RLN tissues sufficient for pathological or cytological diagnosis...
May 9, 2018: Cancer communications
https://www.readbyqxmd.com/read/29759073/laparoscopic-splenectomy-for-solitary-splenic-metastasis-in-a-patient-with-ovarian-cancer-with-a-long-disease-free-interval-a-case-report
#3
Katsuhiko Yasuda, Tomoo Yoshimura, Hiroaki Kitade, Hidesuke Yanagida, Naoki Hosaka
BACKGROUND: In general, splenic metastasis of epithelial ovarian cancer is considered a terminal stage resulting in widespread metastasis. Solitary splenic metastasis of epithelial ovarian cancer is rare in patients with post-treatment ovarian cancer with long disease-free intervals. CASE PRESENTATION: We report a case of a 62-year-old Japanese woman who presented with elevated serum cancer antigen 125 due to a solitary splenic metastasis of ovarian cancer. She underwent primary open cytoreduction including resection of the right ovarian cancer and postoperative chemotherapy, followed by secondary open cytoreduction and additional postoperative chemotherapy...
May 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29745092/therapeutic-benefits-of-neoadjuvant-and-post-operative-denosumab-on-sacral-giant-cell-tumor-a-retrospective-cohort-study-of-30-cases
#4
Zhongyan Chen, Yi Yang, Wei Guo, Rongli Yang, Xiaodong Tang, Taiqiang Yan, Tao Ji, Lu Xie, Jie Xu, Jun Wang
PURPOSE: Denosumab, a new monoclonal antibody that inhibits receptor activator for nuclear factor Kβ ligand (RANKL), has recently been approved by FDA for the treatment of aggressive giant cell tumor of bone (GCTB). So we initiated this study to evaluate the clinical benifits of denosumab used preoperatively or postoperatively. METHODS: Patients diagnosed with classic sacral GCT without metastasis were included in this study. Patients were assigned into 3 groups according to the use of denosumab: control group 1, post-operative group 2 and neoadjuvant group 3...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29744471/outcomes-of-salvage-radical-prostatectomy-following-more-than-one-failed-local-therapy
#5
Arjun Sivaraman, Peter Scardino, James Eastham
Purpose: To describe the salvage radical prostatectomy (sRP) experience in patients presenting with recurrent, clinically localized prostate cancer after multiple failed local treatments. Materials and Methods: Among the 251 sRP performed during 2000-2016, 11 patients had failed multiple local therapies. We describe baseline clinical characteristics at primary cancer diagnosis and prior to sRP, surgical information, complications and oncological outcomes. Results: The mean±standard deviation age at sRP was 65±5 years and the median (interquartile range) serum prostate-specific antigen (PSA) level was 2 (1...
May 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29742697/giant-malignant-pheochromocytoma-in-an-elderly-patient-a-case-report
#6
Chengquan Ma, Erlin Sun, Bingxin Lu
RATIONALE: Malignant pheochromocytoma is a rare disease and surgical resection is the only curative treatment. PATIENT CONCERNS: An 81-year-old man of Chinese ethnicity was found to have a giant retroperitoneal tumor. DIAGNOSES: B-scan ultrasonography and CT scan presented a mass above the left kidney, measuring 13.5 × 10 .6 × 9.8 cm. Subsequent analysis of 24-h urinary catecholamines and vanillylmandelic acid, as well as of blood catecholamines and blood cortisol, showed no elevated levels...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29739453/spontaneous-renal-hemorrhage-secondary-to-choriocarcinoma-in-a-man-with-congenital-hypospadias-and-cryptorchidism-a-case-report-and-literature-review
#7
Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-Yu Xiong, Zi-Yi Yang, Yun-Xiao Zhu, Nathan Jeffreys
BACKGROUND: Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcinoma has previously been only reported in females. We present what we believe to be the first case of a male patient with genital malformation (hypospadias and cryptorchidism) and SRH at presentation of choriocarcinoma. CASE PRESENTATION: A 25-year-old man presented to the department with intense pain in the right flank region and lower back...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29736685/emerging-trends-in-the-management-of-brain-metastases-from-non-small-cell-lung-cancer
#8
REVIEW
Thomas M Churilla, Stephanie E Weiss
PURPOSE OF REVIEW: To summarize current approaches in the management of brain metastases from non-small cell lung cancer (NSCLC). RECENT FINDINGS: Local treatment has evolved from whole-brain radiotherapy (WBRT) to increasing use of stereotactic radiosurgery (SRS) alone for patients with limited (1-4) brain metastases. Trials have established post-operative SRS as an alternative to adjuvant WBRT following resection of brain metastases. Second-generation TKIs for ALK rearranged NSCLC have demonstrated improved CNS penetration and activity...
May 7, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29733989/prognostic-factors-of-ambulatory-status-for-patients-with-metastatic-spinal-cord-compression-a-systematic-review-and-meta-analysis
#9
Yongheng Liu, Yongcheng Hu, Xionggang Yang, Dengxing Lun, Feng Wang, Li Yang, Hao Zhang, Jiangtao Feng, Kunchi Hua
BACKGROUND: This study aimed to identify prognostic factors for functional outcome of metastatic spinal cord compression (MSCC). METHODS: All full texts in English regarding the prognostic factors for functional outcome of MSCC, published between January 2007 and October 2017, were identified using the electronic databases PubMed, Embase, and the Cochrane Library. An exploratory meta-analysis was also conducted when appropriate data were available. RESULT: A total of 25 studies, involving 4897 patients, met the inclusion criteria...
May 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29733890/in-vivo-near-infrared-fluorescence-imaging-and-dynamic-quantification-of-pancreatic-metastatic-tumors-using-folic-acid-conjugated-biodegradable-mesoporous-silica-nanoparticles
#10
Hanrui Li, Ke Li, Yunpeng Dai, Xinyi Xu, Xu Cao, Qi Zeng, Huyulong He, Liaojun Pang, Jimin Liang, Xueli Chen, Yonghua Zhan
Cancer metastasis is one of the biggest challenges in cancer treatments since it increases the likelihood that a patient will die from the disease. Therefore, the availability of techniques for the early detection and quantification of tumors is very important. We have prepared cyanine 7.5 NHS ester (Cy7.5 ) and folic acid (FA) conjugated biodegradable mesoporous silica nanoparticles (bMSN@Cy7.5 -FA NPs) (~100 nm) for visualizing tumors in vivo. The fluorescence spectra revealed that the emission peak of bMSN@Cy7...
May 4, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29733795/muscle-invasive-bladder-and-urethral-cancer-recurrence-after-surgical-management-of-upper-tract-urothelial-carcinoma-a-review-of-305-patients
#11
Mohamed Mohamed Elawdy, Yasser Osman, Diaa Eldin Taha, Samer El-Halwagy
OBJECTIVE: Bladder cancer recurrence after management of upper tract urothelial carcinoma (UTUC) is a common disease. Although the incidence and risk factors for the development of noninvasive bladder tumor have been reported in many series, rare studies have reported on muscle invasive bladder cancer (MIBC) and its urethral recurrence. We aimed to report the incidence, risk factors and survival rate for the development of MIBC and urethral tumors after surgical management of UTUC. MATERIAL AND METHODS: We retrospectively reviewed patients who were surgically treated for UTUC from 1983 to 2013...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29732420/functional-and-survival-outcomes-in-patients-undergoing-surgical-treatment-for-metastatic-disease-of-the-spine
#12
Vignesh K Alamanda, Myra M Robinson, Jeffrey S Kneisl, Joshua C Patt
Background: Retrospective review of a prospective database. Spine metastasis has been shown to occur in 40% of cancer patients with an annual incidence of over 18,000 cases in North America alone. In this study, we sought to explore the functional and survival outcomes of patients undergoing surgical treatment for metastatic disease of the spine. Methods: A retrospective cohort study of a prospective database at a major cancer center was conducted. A total of 55 patients who met the inclusion criteria from January 2010 to December 2015 were included...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29731099/oncologic-outcomes-of-post-kidney-transplantation-superficial-urothelial-carcinoma
#13
G-L Huang, H-L Luo, Y-T Chen, Y-T Cheng
PURPOSE: To analyze the oncologic effect of post-kidney transplantation (KT) immunosuppressive status for end-stage renal disease (ESRD) patients with superficial urothelial carcinoma. METHODS: From 2010 to 2015, there were 106 ESRD patients with superficial urinary bladder urothelial carcinoma (UB-UC) and 68 ESRD patients with superficial upper urinary tract urothelial carcinoma (UT-UC) in a single institution. Oncologic outcomes including bladder cancer recurrences and systemic disease recurrences within 5 years were compared between patients with and without KT...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29725462/mir-205-regulates-the-proliferation-and-invasion-of-ovarian-cancer-cells-via-suppressing-pten-smad4-expression
#14
Ping Chu, Aihua Liang, Aili Jiang, Lu Zong
MicroRNAs (miRNAs/miRs) are non-coding RNAs that post-transcriptionally control target genes, and are involved in tumorigenesis, apoptosis, proliferation, invasion, metastasis and chemoresistance. However, data concerning miRNAs in ovarian cancer remain incomplete. The present study aimed to identify miRNAs that affected the malignant phenotype of ovarian cancer, and to analyze their potential mechanisms. The data demonstrated that miR-205 promoted cell proliferation and invasion of ovarian cancer cells via suppressing Phosphatase and tensin homolog (PTEN)/mothers against decapentaplegic homolog 4 (SMAD4) expression...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29723251/spatiotemporal-assessment-of-spontaneous-metastasis-formation-using-multimodal-in-vivo-imaging-in-her2-and-triple-negative-metastatic-breast-cancer-xenograft-models-in-mice
#15
Inga B Fricke, Raquel De Souza, Lais Costa Ayub, Giulio Francia, Robert Kerbel, David A Jaffray, Jinzi Zheng
BACKGROUND: Preclinical breast cancer models recapitulating the clinical course of metastatic disease are crucial for drug development. Highly metastatic cell lines forming spontaneous metastasis following orthotopic implantation were previously developed and characterized regarding their biological and histological characteristics. This study aimed to non-invasively and longitudinally characterize the spatiotemporal pattern of metastasis formation and progression in the MDA-MB-231-derived triple negative LM2-4 and HER2+ LM2-4H2N cell lines, using bioluminescence imaging (BLI), contrast enhanced computed tomography (CT), fluorescence imaging, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose positron emission tomography ([18F]FDG-PET)...
2018: PloS One
https://www.readbyqxmd.com/read/29719451/establishment-and-evaluation-of-the-vx2-orthotopic-lung-cancer-rabbit-model-a-ultra-minimal-invasive-percutaneous-puncture-inoculation-method
#16
Lijuan Wang, Keke Che, Zhonghong Liu, Xianlong Huang, Shifeng Xiang, Fei Zhu, Yu Yu
The purpose of the present work is to establish an ultra-minimal invasive percutaneous puncture inoculation method for a VX2 orthotopic lung cancer rabbit model with fewer technical difficulties, lower mortality of rabbits, a higher success rate and a shorter operation time, to evaluate the growth, metastasis and apoptosis of tumor by CT scans, necropsy, histological examination, flow cytometry and immunohistochemistry. The average inoculation time was 10-15 min per rabbit. The tumor-bearing rate was 100%. More than 90% of the tumor-bearing rabbits showed local solitary tumor with 2-10 mm diameters after two weeks post-inoculation, and the rate of chest seeding was only 8...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29718672/evaluation-of-anti-lgr5-antibodies-by-immunopet-for-imaging-colorectal-tumors-and-development-of-antibody-drug-conjugates
#17
Ali Azhdarinia, Julie Voss, Sukhen C Ghosh, Jo A Simien, Servando Hernandez Vargas, Jie Cui, Wangsheng A Yu, Qingyun Liu, Kendra S Carmon
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is highly expressed in colorectal tumors and marks colon cancer stem cells that drive tumor growth and metastasis. Recently, we showed that LGR5 is a promising target for antibody-drug conjugate (ADC) therapy. However, it is important to identify LGR5-positive tumors that would respond ADC treatment. Prior to drug conjugation, we evaluated two different anti-LGR5 monoclonal antibodies (mAbs), 8F2 and 9G5, using 89Zr-immunoPET to select the optimal mAb for ADC development and tumor imaging...
May 2, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29712908/the-novel-hsa-mir-12528-regulates-tumourigenesis-and-metastasis-through-hypo-phosphorylation-of-akt-cascade-by-targeting-igf-1r-in-human-lung-cancer
#18
Seong Ho Jeon, Jung Ki Yoo, Chang Min Kim, Eun Su Lim, So Jeong Lee, Ji Min Lee, Seung-Hun Oh, Jin Kyeoung Kim
Lung cancer cases are increasing yearly; however, few novel therapeutic strategies for treating this disease have been developed. Here the dysregulation between microRNAs and oncogenes or tumour-suppressor genes forms a close connection-loop to the development or progression in human lung carcinogenesis. That is, the relationship between microRNAs and carcinogenic mechanism may find the critical clue to improve the treatment efficacy. Accordingly, we identified and characterised a novel microRNA, hsa-miR-12528, in A549 cells...
May 1, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29701419/carotid-paraganglioma-classical-surgical-technique
#19
Bárbara Pereira, Manuel Fonseca, Anabela Gonçalves, João Alegrio, Óscar Gonçalves
INTRODUCTION: A carotid body tumor is a rare neoplasm, generally benign, that predominantly affects people between their fourth and fith decades of life. It manifests as a pulsatile and generally painless cervical mass with firm consistency, located below the angle of the jaw. Clinically it can cause localized pain, dysphagia, hiccups, hoarseness and hypersensitive carotid body syndrome. Surgery is the treatment of choice, bearing in mind the possibility of malignant transformation, peritumoral invasion and metastasis...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29699571/safety-and-efficacy-of-dehydrated-ethanol-soaking-of-the-operative-field-in-the-treatment-of-spontaneous-hepatocellular-carcinoma-rupture
#20
Jian Sun, Yue Zhu, Yao-Rong Peng, Wen-Bin Li, He-Yun Zhang, Zhen-Yu Zhou, Lin Wang, An-de Ma, Jie Wang
BACKGROUND: The aim of our study was to evaluate the clinical safety and value of ethanol surgical field infiltration (ESFI), combined with distilled water peritoneal lavage (DWPL), after hepatectomy in patients with hepatocellular carcinoma (HCC) rupture. METHODS: Rat liver tissue samples were soaked in dehydrated ethanol for different soaking times, and 18 rats were assigned to three groups that underwent different soaking methods of the hepatectomy cut surface...
April 26, 2018: World Journal of Surgical Oncology
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