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https://www.readbyqxmd.com/read/28922727/the-relevance-of-gastric-cancer-biomarkers-in-prognosis-and-pre-and-post-chemotherapy-in-clinical-practice
#1
REVIEW
Muhammad Abbas, Murad Habib, Muhammad Naveed, Kumaragurubaran Karthik, Kuldeep Dhama, Meiqi Shi, Chen Dingding
Gastric cancer (GC) is one among the major cancer types, causing human deaths and present noticeable heterogeneity. The incidences and mortality rates are higher in males in comparison to females with a male to female ratio of 2.3:1. A lot of studies have revealed out the molecular basis, pathogenesis, invasion and metastasis related findings of gastric stomach cancer. Present review encompasses the salient information on various biomarkers for the early diagnosis, treatment and prognosis of gastric cancer elaborate the clinical importance of serum tumor markers in patients with this cancer as well as checking the growths, together with epigenetic changes and genetic polymorphisms...
September 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28916273/identification-of-recurrence-sites-following-post-prostatectomy-treatment-for-prostate-cancer-using-11-c-choline-positron-emission-tomography-and-multiparametric-pelvic-mri
#2
Avinash Nehra, William P Parker, Rimki Haloi, Sean S Park, Lance A Mynderse, Val J Lowe, Brian J Davis, J Fernando Quevedo, Geoffrey B Johnson, Eugene D Kwon, R Jeffrey Karnes
PURPOSE: To describe anatomic sites of recurrence among prostate cancer patients with biochemical recurrence following radical prostatectomy (RP) and postoperative radiotherapy (RT) and/or androgen deprivation therapy (ADT) using (11)C-Choline PET/CT and multiparametric-MRI. MATERIALS AND METHODS: RP patients evaluated with (11)C-Choline PET/CT and multiparametric-MRI following RT and/or ADT were evaluated for patterns of recurrence and clinicopathologic features...
September 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28915408/transarterial-chemoembolisation-for-breast-cancer-with-liver-metastasis-a-systematic-review
#3
REVIEW
Mengchuan Wang, Jian Zhang, Shufeng Ji, Guoli Shao, Kankan Zhao, Zixiang Wang, Aiguo Wu
BACKGROUND: There is limited data on the impact of transarterial chemoembolisation (TACE) on survival in patients of breast cancer with liver metastasis (BCLM). METHODS: A systematic review was conducted to assess TACE effect on BCLM patients. A search for clinical studies published since 1/1/2000 to 1/1/2017 was performed. Survival data from all studies were extracted to evaluate the efficacy of TACE, including overall survival, disease free survival and response rate...
September 12, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28900507/targeting-micrornas-in-prostate-cancer-radiotherapy
#4
REVIEW
Jie Ni, Joseph Bucci, Lei Chang, David Malouf, Peter Graham, Yong Li
Radiotherapy is one of the most important treatment options for localized early-stage or advanced-stage prostate cancer (CaP). Radioresistance (relapse after radiotherapy) is a major challenge for the current radiotherapy. There is great interest in investigating mechanisms of radioresistance and developing novel treatment strategies to overcome radioresistance. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level, participating in numerous physiological and pathological processes including cancer invasion, progression, metastasis and therapeutic resistance...
2017: Theranostics
https://www.readbyqxmd.com/read/28898798/free-disease-long-term-survival-in-primary-thoracic-spine-leiomyosarcoma-after-total-en-bloc-spondylectomy-a-case-report
#5
José Ramirez-Villaescusa, Adriana Canosa-Fernández, Antonio Martin-Benlloch, David Ruiz-Picazo, Jesús López-Torres Hidalgo
INTRODUCTION: To describe an unusual primary vertebral leiomyosarcoma in thoracic spine. PRESENTATION OF CASE: An isolated lesion of the T11 vertebra in a 62-year-old woman with no neurologic deficit is reported. Imaging findings indicated a nonspecific high-grade malignant lesion. TC-guided biopsy failed thus open incisional biopsy was needed. A diagnosis of low-intermediate mesenchymal sarcoma was made. A total en bloc spondylectomy of T11 was performed with three-column reconstruction...
September 1, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28888798/impact-of-body-mass-index-on-treatment-outcome-of-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#6
REVIEW
Y Sun, Z Xu, H Lin, X Lu, Y Huang, S Huang, X Wang, P Chi
AIM: To determine the effect of obesity, measured by body mass index (BMI), on tumor response and surgical outcome in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (nCRT) and radical surgery. METHOD: LARC patients undergoing nCRT and radical surgery from 2008 to 2014 were included and divided into three groups: non-obese (BMI < 25.0 kg/m(2)), obese I (BMI 25.0-29.9 kg/m(2)), and obese II (BMI ≥ 30.0 kg/m(2))...
August 10, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28885675/up-regulated-hmgb1-in-the-pleural-effusion-of-non-small-cell-lung-cancer-nsclc-patients-reduces-the-chemosensitivity-of-nsclc-cells
#7
Ying Ma, Shirong Kang, Xu Wu, Bateer Han, Zhiyong Jin, Zhanlin Guo
BACKGROUND: Pleural effusion is one of the complications of human non-small cell lung cancer (NSCLC). High mobility group box-1 protein (HMGB1) correlates highly with invasion and metastasis in multiple tumors. The aim of this study was to explore the clinical value of HMGB1 in NSCLC patients, and to investigate the role of HMGB1 in the development of pleural effusion. In addition, we also investigated the regulatory role of HMGB1 in the sensitivity of NSCLC cells to cisplatin. METHODS: 46 NSCLC malignant pleural effusion (MPE) and 31 benign pleural effusion samples were quantitatively analyzed with Enzyme-Linked Immunosorbent Assay (ELISA) for cytokines, such as IL-1beta, IL-6, IL-8 and HMGB1...
September 2, 2017: Tumori
https://www.readbyqxmd.com/read/28880997/the-role-of-the-mir-148-152-family-in-physiology-and-disease
#8
REVIEW
Michael Friedrich, Katharina Pracht, Mir-Farzin Mashreghi, Hans-Martin Jäck, Andreas Radbruch, Barbara Seliger
MicroRNAs (miRNAs) are endogenously encoded ∼22 nt small non-coding RNAs. They function as key players of many cellular processes by base pairing with target mRNAs and thereby impairing gene expression at the post-transcriptional level. Recent findings demonstrate a critical role of many miRNAs in immune cell differentiation and immune responses, which is also associated with the development and progression of many tumor and non-tumor diseases. Here we review the multifaceted miRNA-148/-152 family members consisting of miR-148a, miR-148b and miR-152...
September 7, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28879511/risk-factors-for-unresectable-recurrence-after-up-front-surgery-for-colorectal-liver-metastasis
#9
Daisuke Hokuto, Takeo Nomi, Satoshi Yasuda, Takahiro Yoshikawa, Kohei Ishioka, Takatsugu Yamada, Takahiro Akahori, Kenji Nakagawa, Minako Nagai, Kota Nakamura, Shinsaku Obara, Hiromichi Kanehiro, Masayuki Sho
BACKGROUND: There is no clear evidence that preoperative chemotherapy for resectable colorectal liver metastasis (CRLM) is superior to up-front surgery (UFS). The aim of this study was to identify the risk factors associated with poor prognosis after UFS for CRLM. METHODS: Data about consecutive patients with CRLM who underwent liver resection at Nara Medical University Hospital between January 2000 and December 2015 were retrieved from a prospective database. Recurrence that developed within 2 years after liver resection and could not be surgically resected was defined as unresectable recurrence (UR)...
September 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28878853/bilateral-renal-metastasis-of-h%C3%A3-rthle-cell-thyroid-cancer-with-discordant-uptake-between-i-131-sodium-iodide-and-f-18-fdg
#10
Apichaya Claimon, Minseok Suh, Gi Jeong Cheon, Dong Soo Lee, E Edmund Kim, June-Key Chung
Renal metastasis of thyroid cancer is extremely rare. We report the case of a 62-year-old woman with Hürthle cell thyroid cancer (HCTC) with lungs, bones, and bilateral kidneys metastases. The renal metastatic lesions were clearly demonstrated by (131)I whole body scan (WBS) with SPECT/CT. However, they exhibited false-negative results in (18)F-FDG PET/CT, kidney ultrasonography, and contrast-enhanced CT scan. The findings imply that tumors have low glucose metabolism and are able to accumulate radioiodine, which is not commonly found in the relatively aggressive nature of HCTC...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28874625/a-rare-case-of-squamous-cell-carcinoma-of-a-proliferating-trichilemmal-tumour
#11
Bruno Di Pace, Vincenzo Verdura, Marina Concilio, Carlo Baldi, Pio Zeppa, Giovanni Francesco Nicoletti, Corrado Rubino
INTRODUCTION: Squamous Cell Carcinoma (SCC) includes several subtypes and these can be classified according to their clinical behaviours from the least invasive to the most aggressive. Moreover, it is appropriate to analyse their clinicalpathological patterns 1. In light of its wide histopathological variability, we encountered a rare malignant cutaneous lesion: a SCC of a proliferating trichilemmal tumour (PTT) nature. CASE REPORT: We describe the clinical and pathologic findings of an 82-year-old woman, who developed a SCC with areas of trichilemmal differentiation...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28869173/-ablative-therapy-in-kidney-cancer-indications
#12
T Tricard, G Tsoumakidou, V Lindner, J Garnon, G Albrand, X Cathelineau, A Gangi, H Lang
BACKGROUND: Ablative therapies (AT) in kidney cancer are rising. It's important to evaluate the situation of this therapy. The aim of this study is to identify the best indications for AT treatment for kidney cancer. METHODS: Review of literature using Medline and Embase databases. Study were selected based on scientific relevance. Clinical keys centered on the best requirements to indicate ablative therapies. RESULTS: AT is indicated according to specific tumor and patients criteria...
August 28, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28867585/protein-phosphorylation-and-its-role-in-the-regulation-of-annexin-a2-function
#13
REVIEW
Ann Kari Grindheim, Jaakko Saraste, Anni Vedeler
BACKGROUND: Annexin A2 (AnxA2) is a multifunctional protein involved in endocytosis, exocytosis, membrane domain organisation, actin remodelling, signal transduction, protein assembly, transcription and mRNA transport, as well as DNA replication and repair. SCOPE OF REVIEW: The current knowledge of the role of phosphorylation in the functional regulation of AnxA2 is reviewed. To provide a more comprehensive treatment of this topic, we also address in depth the phosphorylation process in general and discuss its possible conformational effects...
September 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28864073/treatment-outcomes-after-reduction-of-the-target-volume-of-intensity-modulated-radiotherapy-following-induction-chemotherapy-in-patients-with-locoregionally-advanced-nasopharyngeal-carcinoma-a-prospective-multi-center-randomized-clinical-trial
#14
Hongru Yang, Xin Chen, Sheng Lin, Jinfeng Rong, Mi Yang, Qinglian Wen, Changling Shang, Lijia He, Peirong Ren, Shan Xu, Jianwen Zhang, Qiaoli Liu, Haowen Pang, Xiangxiang Shi, Juan Fan, Xiaoyang Sun, Daiyuan Ma, Bangxian Tan, Tao Zhang, Ling Zhang, Defeng Hu, Xiaobo Du, Yu Zhang, Shiming Wen, Xinping Zhang, Jingbo Wu
PURPOSE: To investigate whether reducing the target volume of intensity-modulated radiotherapy (IMRT) after induction chemotherapy (IC) improves the quality of life (QOL) in locoregionally advanced nasopharyngeal carcinoma (NPC) without decreasing the local control and survival rate. PATIENTS AND METHODS: A total number of 212 NPC patients staged as III-IVb were randomly assigned to group A (n=97) or group B (n=115) in this prospective clinical trial. All patients received IC followed by cisplatin concurrent with IMRT...
August 29, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28861931/the-ubiquitin-ligase-trim25-inhibits-hepatocellular-carcinoma-progression-by-targeting-metastasis-associated-1-protein
#15
Hong-Liang Zang, Sheng-Nan Ren, Hong Cao, Xiao-Feng Tian
Metastasis associated 1 protein (MTA1) is one of the prime facilitators of metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). However, the underlying regulatory mechanism of MTA1 expression in HCC is not clear. In this study, we evaluated MTA1 transcript and protein expression in HCC and normal hepatic cell lines. The results revealed that MTA1 protein expression had a significantly increase in HCC cell line, HuH6, compared with that in normal hepatic cell line, THLE-2. Determination of protein half-life using cycloheximide (CHX) treatment did not reveal any statistically significant difference in protein turn-over rates between THLE-2 (3...
August 31, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28859371/treatment-strategies-in-recurrent-esophageal-or-junctional-cancer
#16
R Butter, S M Lagarde, M G H van Oijen, M C J Anderegg, S S Gisbertz, S L Meijer, M C C M Hulshof, J J G H M Bergman, M I van Berge Henegouwen, H W M van Laarhoven
Little evidence is available about survival rates in patients with recurrent disease after potentially curative surgery for esophageal or junctional cancer. Only in limited occasions, potentially curative salvage strategies are available. The aim of this study is to analyze survival rates and patterns of dissemination, and to identify independent prognostic factors in a consecutive series of patients who develop recurrent esophageal or junctional cancer. Between 1994 and 2015, patients who developed disease recurrence after neoadjuvant chemo(radio)therapy followed by radical esophagectomy for esophageal or junctional cancer were retrospectively analyzed...
September 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28851315/propensity-score-matching-analysis-of-a-phase-ii-study-on-simultaneous-modulated-accelerated-radiation-therapy-using-helical-tomotherapy-for-nasopharyngeal-carcinomas
#17
Lei Du, Xin-Xin Zhang, Lin-Chun Feng, Bao-Lin Qu, Jing Chen, Jun Yang, Hai-Xia Liu, Shou-Ping Xu, Chuan-Bin Xie, Lin Ma
BACKGROUND: Using propensity score matching method (PSM) to evaluate the feasibility and clinical outcomes of simultaneous modulated accelerated radiation therapy (SMART) using helical tomotherapy (HT) in patients with nasopharyngeal carcinoma (NPC). METHODS: Between August 2007 and January 2016, 381 newly diagnosed NPC patients using HT were enrolled in pre-PSM cohort, including 161 cases in a prospective phase II study (P67.5 study, with a prescription dose of 67...
August 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28834778/outcomes-of-radioembolization-for-unresectable-hepatocellular-carcinoma-in-patients-with-marginal-functional-hepatic-reserve
#18
Derek M Biederman, Raghuram Posham, Raisa J Durrani, Joseph J Titano, Rahul S Patel, Nora E Tabori, Francis S Nowakowski, Aaron M Fischman, Robert A Lookstein, Edward Kim
PURPOSE: To evaluate the outcomes of radioembolization (RE) as a therapy for unresectable hepatocellular carcinoma (HCC) in patients with marginal functional hepatic reserve. METHODS: A retrospective review of 471 patients (1/2010-7/2015) treated with RE (Therasphere, BTG, UK) was performed. A total of 36 patients (mean age: 66.1±9.3, male: 86.1%) underwent therapy for HCC with a MELD≥15 (median: 16, range: 15-22). Baseline demographics of the study cohort were as follows: etiology (HCV: 26, 72...
July 20, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28828510/prognostic-value-of-lymph-node-to-primary-tumor-standardized-uptake-value-ratio-in-endometrioid-endometrial-carcinoma
#19
Hyun Hoon Chung, Gi Jeong Cheon, Jae-Weon Kim, Noh-Hyun Park, Yong Sang Song
PURPOSE: To determine whether the relative metabolic activity of pelvic or para-aortic LN compared with that of primary tumor measured by preoperative [(18)F]FDG PET/CT scan has prognostic value in patients with endometrioid endometrial carcinoma. METHODS: We retrospectively reviewed patients with endometrioid endometrial carcinoma who underwent preoperative [(18)F]FDG PET/CT scans. Prognostic values of PET/CT-derived metabolic variables such as maximum standardized uptake value (SUV) of the primary endometrial carcinoma (SUVTumor) and LN (SUVLN), and the LN-to-endometrial carcinoma SUV ratio (SUVLN / SUVTumor) were assessed...
August 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28825843/immunopet-imaging-of-cd146-in-murine-models-of-intrapulmonary-metastasis-of-non-small-cell-lung-cancer
#20
Christopher Gene England, Dawei Jiang, Reinier Hernandez, Haiyan Sun, Hector F Valdovinos, Emily B Ehlerding, Jonathan W Engle, Yunan Yang, Peng Huang, Weibo Cai
CD146 has been identified as an excellent biomarker for lung cancer as its overexpression in solid tumors has been linked to disease progression, invasion, and metastasis. Previously, our group described a positive correlation between (64)Cu-labeled YY146 uptake and increased expression of CD146 in six human lung cancer cell lines using subcutaneous tumor models. In this study, we investigate a monoclonal antibody called YY146 for immunoPET imaging of CD146 in two intrapulmonary metastasis models of non-small cell lung cancer (NSCLC)...
August 21, 2017: Molecular Pharmaceutics
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