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https://www.readbyqxmd.com/read/29341215/microrna181c-inhibits-prostate-cancer-cell-growth-and-invasion-by-targeting-multiple-erk-signaling-pathway-components
#1
Zhengzheng Su, Mengni Zhang, Miao Xu, Xinglan Li, Junya Tan, Yunyi Xu, Xiuyi Pan, Ni Chen, Xueqin Chen, Qiao Zhou
BACKGROUND: The ERK signaling pathway is frequently deregulated in tumorigenesis, mostly by classical mechanisms such as gene mutation of its components (eg, RAS and RAF). However, whether and how multiple key components of ERK pathway are regulated by microRNAs are not clear. METHODS: We firstly predicted post-transcriptional regulation of multiple key components of the ERK signaling pathway by miR181c through bioinformatics analysis, and then confirmed the post-transcriptional regulation by dual luciferase reporter gene assays and Western blot analysis...
January 16, 2018: Prostate
https://www.readbyqxmd.com/read/29340908/fasting-blood-glucose-level-in-locally-advanced-non-small-cell-lung-cancer-a-new-prognostic-factor
#2
Esra Korkmaz Kirakli, Ufuk Yilmaz, Hasan Yilmaz, Berna Komurcuoglu
Hyperglycemia may lead to proliferation, invasion, apoptosis inhibition, migration, and eventually metastasis of cancer cells by several mechanisms. In this study, the effect of hyperglycemia on overall survival (OS), disease-free survival (DFS), and locoregional recurrence (LRR) was investigated in NSCLC. One stage IIIA-IIIB NSCLC patient treated with chemoradiotherapy between 2010 and 2015 was enrolled. Fasting blood glucose (FBG) levels were recorded in pre-treatment, treatment, and post-treatment periods...
January 16, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29340482/clear-cell-odontogenic-carcinoma-of-the-mandible-a-treatment-strategy
#3
Sabrina Ferreira, Leonardo Perez Faverani, Gabriel Mulinari Dos Santos, Everton Pontes Martins, Idelmo Rangel Garcia Júnior
Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws, histologically characterized by the presence of agglomerates of cells with eosinophilic cytoplasm. The patient, a 62-year-old Caucasian woman, presented an intraosseous lesion in the mandibular symphysis. A clinical examination revealed a discrete volumetric increase with a hard consistency, palpable to extraoral and intraoral examinations. Imaging studies revealed an extensive radiolucent area, without defined limits, extending from the region of the right second premolar to the left canine...
January 15, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29337932/high-number-of-circulating-tumor-cells-predicts-poor-survival-of-cutaneous-melanoma-patients-in-china
#4
Jisen Li, Wenhua Fu, Wei Zhang, Peng Li
BACKGROUND Melanoma is an aggressive cancer with complex etiology and poor prognosis. Surgical resection is still the primary treatment of melanoma, but shows limited efficacy in late-stage patients. Additionally, reliable prognostic markers of skin melanoma patients are still lacking. Circulating tumor cells (CTCs) have shown promise in predicting prognosis of multiple cancers. Evaluating the prognostic value of CTC number in melanoma patients. MATERIAL AND METHODS CTCs were isolated by immunomagnetic capture from 7...
January 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29335523/mir-139-5p-inhibits-aerobic-glycolysis-cell-proliferation-migration-and-invasion-in-hepatocellular-carcinoma-via-a-reciprocal-regulatory-interaction-with-ets1
#5
Shengni Hua, Ling Lei, Ling Deng, Xie Weng, Chengdong Liu, Xiaolong Qi, Shuang Wang, Dongyan Zhang, Xuejing Zou, Chuanhui Cao, Li Liu, Dehua Wu
Cancer cells have metabolic features that allow them to preferentially metabolize glucose through aerobic glycolysis, providing them with a progression advantage. However, microRNA (miRNA) regulation of aerobic glycolysis in cancer cells has not been extensively investigated. We addressed this in the present study by examining the regulation of miR-139-5p on aerobic glycolysis of hepatocellular carcinoma (HCC) using clinical specimens, HCC cells, and a mouse xenograft model. We found that overexpressing miR-139-5p restrained aerobic glycolysis, suppressing proliferation, migration, and invasion in HCC cells...
January 16, 2018: Oncogene
https://www.readbyqxmd.com/read/29328371/cd133-expression-predicts-post-operative-recurrence-in-patients-with-colon-cancer-with-peritoneal-metastasis
#6
Hiroshi Nagata, Soichiro Ishihara, Junko Kishikawa, Hirofumi Sonoda, Koji Murono, Shigenobu Emoto, Manabu Kaneko, Kazuhito Sasaki, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa
Despite extensive research on cancer stem cells in colorectal cancer, the impact of stem cell markers on patient survival remains unclear, particularly in those with distant metastasis. In this study, we focused on colon cancer with peritoneal metastasis and investigated the association between the expression of CD133, aldehyde dehydrogenase-1 (ALDH1) and leucine-rich repeating G-protein coupled receptor-5 (Lgr5), and disease prognosis. Putative stem cell marker expression was immunohistochemically evaluated in samples from 142 primary tumours and 75 peritoneal nodules...
January 8, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29322294/ticagrelor-inhibits-platelet-tumor-cell-interactions-and-metastasis-in-human-and-murine-breast-cancer
#7
Alison J Gareau, Colin Brien, Simon Gebremeskel, Robert S Liwski, Brent Johnston, Michael Bezuhly
Activated platelets promote the proliferation and metastatic potential of cancer cells. Platelet activation is largely mediated through ADP engagement of purinergic P2Y12 receptors on platelets. We examined the potential of the reversible P2Y12 inhibitor ticagrelor, an agent used clinically to prevent cardiovascular and cerebrovascular events, to reduce tumor growth and metastasis. In vitro, MCF-7, MDA-MB-468, and MDA-MB-231 human mammary carcinoma cells exhibited decreased interaction with platelets treated with ticagrelor compared to untreated platelets...
January 11, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29319129/cerebellar-metastasis-of-papillary-thyroid-carcinoma-detected-with-somatostatin-receptor-scintigraphy
#8
Rafal Czepczynski, Anna Wyszomirska, Maria Gryczynska, Ewelina Szczepanek-Parulska, Marek Ruchala
BACKGROUND: Distant metastases of papillary thyroid carcinoma (PTC) may lack the ability to concentrate radioiodine. In such cases, positive somatostatin receptor scintigraphy might be useful in demonstrating the expression of somatostatin receptors that are potential therapeutic targets. To date, only several cerebellar metastases from PTC have been reported in the literature. PATIENT FINDINGS: We present an 82-year-old female, in whom an asymptomatic cerebellar metastasis from PTC was diagnosed by the means of Tc-99m-EDDA/HYNIC-TOC scintigraphy four years following the initial diagnosis...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29313973/mouse-model-of-post-surgical-primary-tumor-recurrence-and-regional-lymph-node-metastasis-progression-in-hpv-related-head-and-neck-cancer
#9
Maxime Mermod, Agnès Hiou-Feige, Esther Bovay, Vincent Roh, Jana Sponarova, Massimo Bongiovanni, Daniel W Vermeer, John H Lee, Tatiana V Petrova, Jean-Paul Rivals, Yan Monnier, Genrich V Tolstonog, Christian Simon
HPV-positive head and neck squamous cell carcinoma (HNSCC) is increasingly frequent. Management is particularly debated in the case of post-surgical high-risk features, i.e., positive surgical margins and extracapsular spread (ECS). In this increasingly complex emerging framework of HNSCC treatment, representative pre-clinical models are needed to support future clinical trials and advances in personalized medicine. Here, we present an immunocompetent mouse model based on the implantation of mouse tonsil epithelial HPV16-E6/E7-expressing cancer cells into the submental region of the floor-of-the-mouth...
January 4, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29302577/rna-binding-protein-as-an-emerging-therapeutic-target-for-cancer-prevention-and-treatment
#10
REVIEW
Suntaek Hong
After transcription, RNAs are always associated with RNA binding proteins (RBPs) to perform biological activities. RBPs can interact with target RNAs in sequence- and structure-dependent manner through their unique RNA binding domains. In development and progression of carcinogenesis, RBPs are aberrantly dysregulated in many human cancers with various mechanisms, such as genetic alteration, epigenetic change, noncoding RNA-mediated regulation, and post-translational modifications. Upon deregulation in cancers, RBPs influence every step in the development and progression of cancer, including sustained cell proliferation, evasion of apoptosis, avoiding immune surveillance, inducing angiogenesis, and activating metastasis...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29299166/early-morphological-change-for-predicting-outcome-in-metastatic-colorectal-cancer-after-regorafenib
#11
Hiroyuki Arai, Kunihisa Miyakawa, Tadamichi Denda, Takuro Mizukami, Yoshiki Horie, Naoki Izawa, Mami Hirakawa, Takashi Ogura, Takashi Tsuda, Yu Sunakawa, Takako Eguchi Nakajima
Background and Objective: It is unclear whether early morphological change (EMC) is a predictive marker for regorafenib in metastatic colorectal cancer (mCRC). Therefore, the present study investigated whether EMC can predict the outcome of mCRC patients receiving regorafenib. Results: This study evaluated 68 patients. Among 52 patients with lung metastasis, 16 (31%) had cavity formation (CF). The median progression-free survival (PFS) and overall survival (OS) in patients with/without CF were 4...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29288844/primary-extradural-melanoma-arising-in-cervical-spinal-nerve-root
#12
Cunyi Zou, Wen Cheng, Chen Zhu, Qing Guo, Anhua Wu
BACKGROUND: Primary cervical melanoma is rare; this is especially true of extradural melanoma arising in the nerve root. Characterizing these cases can provide a basis for improved melanoma management. CASE DESCRIPTION: A 42-year-old female patient with numbness and pain in the right shoulder and arm persisting for 5 years was admitted. Preoperative magnetic resonance imaging revealed an epidural ladle-shaped mass shape beyond the C7-T1 intervertebral foramen that resembleda nerve sheath tumor...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29288227/endobronchial-metastasis-of-mixed-mullerian-tumour-of-the-uterus
#13
Vadsala Baskaran, Laura Pugh, Robert James Berg, John Anderson
Endobronchial metastasis occurs in only 2%-5% of non-pulmonary cancers. Here we report on an 84-year-old woman who presented with breathlessness and light-headedness while on holiday in Australia, 2 years post-treatment for endometrial cancer. Initial CT pulmonary angiogram identified a soft tissue mass in the left hemithorax. A chest radiograph performed after repatriation was consistent with a large left pleural effusion, but bedside ultrasound showed a lobulated mass involving the left hemidiaphragm. A pleural procedure in the traditional 'triangle of safety' would have resulted in inadvertent puncture of the underlying mass...
December 28, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29286064/mir-152-is-involved-in-the-proliferation-and-metastasis-of-ovarian-cancer-through-repression-of-erbb3
#14
Lian-Wei Li, Hong-Qi Xiao, Rong Ma, Meng Yang, Wan Li, Ge Lou
MicroRNAs (miRNAs) participate in post-transcriptional regulation by targeting the 3' untranslated region of target genes that are involved in diverse biological processes. To the best of our knowledge, the association between miR‑152 and ERBB3 in ovarian cancer remains unclear. In the present study, a negative correlation between miR‑152 and ERBB3 in ovarian cancer was observed. The luciferase reporter gene assay results demonstrated that miR‑152 negatively regulated ERBB3 in SKOV3 and OVCAR3 ovarian cancer cells...
December 15, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29285202/effective-treatment-of-a-patient-with-stage-iv-ovarian-cancer-a-case-report
#15
Zhen Huang, Hua Yan, Devendra Chavan, Zeng Yuan, Xingsheng Yang, Youzhong Zhang, Kun Song, Beihua Kong
The present case report describes a patient with stage IV ovarian cancer who survived for 9 years without achieving a complete remission since the first relapse. The patient's long-term survival may be ascribed to the slow growth of the cancer cells, limited metastasis and favorable responses to the treatments received. The patient manifested initially with malignant pleural effusion and was not able to tolerate surgical treatment. However, the disease was well-controlled using various treatments, including neoadjuvant chemotherapy, interval cytoreductive surgery and post-operative long-term chemotherapy...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29284672/hospice-admission-and-survival-following-18f-fluoride-pet-performed-for-evaluation-of-osseous-metastatic-disease-in-the-national-oncologic-pet-registry
#16
Ilana F Gareen, Bruce E Hillner, Lucy Hanna, Rajesh Makineni, Fenghai Duan, Anthony F Shields, Rathan M Subramaniam, Barry Siegel
We have previously reported that positron emission tomography using 18F-fluoride (NaF-PET) for assessment of osseous metastatic disease was associated with substantial changes in intended management in Medicare beneficiaries participating in the National Oncologic PET Registry (NOPR). Here, we use Medicare administrative data to examine the association between NaF-PET results and hospice claims within 180 days and 1-year survival. Methods: We classified NOPR NaF-PET results linked to Medicare claims by imaging indication [initial staging (IS); detection of suspected first osseous metastasis (FOM); suspected progression of osseous metastasis (POM); or treatment monitoring (TM)] and type of cancer (prostate, lung, breast or other)...
December 28, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29277434/retinoblastoma-and-optic-nerve-enhancement-in-a-brain-magnetic-resonance-scan-is-it-always-a-metastasis
#17
A Correa-Acosta, M E González-Alviar, M L Gaviria-Bravo
CASE REPORT: The case is presented on a girl with a unilateral retinoblastoma that required treatment with intra-arterial chemotherapy. In the nuclear magnetic resonance imaging of the brain performed 1 month after intra-arterial chemotherapy treatment, post-laminar optic nerve (ON) enhancement was observed, leading to the suspicion of an ON tumour infiltration. Additional examinations were requested by which a probable optic neuropathy was diagnosed. DISCUSSION: The ON enhancement in magnetic resonance imaging of the brain in retinoblastoma generally corresponds to tumour invasion of the ON...
December 22, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29246016/optimal-treatment-strategies-for-clinically-suspicious-lateral-pelvic-lymph-node-metastasis-in-rectal-cancer
#18
Hye Jin Kim, Gyu-Seog Choi, Jun Seok Park, Soo Yeun Park, Seung Hyun Cho, Soo Jung Lee, Byung Woog Kang, Jong Gwang Kim
Background: Although lateral pelvic lymph node (LPN) metastasis is a major cause of local recurrence in patients with rectal cancer, controversy still remains on the treatment of suspected LPN metastasis, "suspicious LPN". We aimed to determine the optimal treatment strategies for suspicious LPN, in patients with locally advanced rectal cancer who underwent preoperative chemoradiotherapy (CRT). Materials and Methods: Of 377 patients who received preoperative CRT for rectal cancer between 2006 and 2013, 84 (22...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29234933/micrornas-and-metastasis-small-rnas-play-big-roles
#19
Jongchan Kim, Fan Yao, Zhenna Xiao, Yutong Sun, Li Ma
MicroRNAs (miRNAs) are small non-coding RNAs regulating post-transcriptional gene expression. They play important roles in many biological processes under physiological or pathological conditions, including development, metabolism, tumorigenesis, metastasis, and immune response. Over the past 15 years, significant insights have been gained into the roles of miRNAs in cancer. Depending on the cancer type, miRNAs can act as oncogenes, tumor suppressors, or metastasis regulators. In this review, we focus on the role of miRNAs as components of molecular networks regulating metastasis...
December 12, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29223525/case-series-of-rare-thymoma-metastases-to-the-spine-and-complete-literature-review
#20
Rebecca L Achey, Bryan S Lee, Swetha Sundar, Edward C Benzel, Ajit A Krishnaney
BACKGROUND: We report a series of three cases of metastatic thymoma to the spine with spinal cord compression. An extensive literature review of thymic metastases to the spine was completed in order to provide a comprehensive appraisal of current prognostic indicators and potential treatment algorithms to help guide clinicians in treatment management. CASE DESCRIPTIONS: Between 2000 and 2017, three patients were diagnosed with thymic metastases to the spine at our institution...
December 6, 2017: World Neurosurgery
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