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https://www.readbyqxmd.com/read/27583688/a-randomized-double-blind-phase-2-trial-of-platinum-therapy-plus-etoposide-with-or-without-concurrent-vandetanib-zd6474-in-patients-with-previously-untreated-extensive-stage-small-cell-lung-cancer-hoosier-cancer-research-network-lun06-113
#1
Rachel E Sanborn, Jyoti D Patel, Gregory A Masters, Nagesh Jayaram, Anthony Stephens, Michael Guarino, Jamal Misleh, Jingwei Wu, Nasser Hanna
BACKGROUND: This randomized, double-blind, phase 2 trial evaluated whether the addition of vandetanib to platinum plus etoposide for previously untreated extensive-stage small cell lung cancer (SCLC) prolonged the time to disease progression in comparison with chemotherapy alone. METHODS: Patients with previously untreated extensive-stage SCLC received platinum (cisplatin or carboplatin) with etoposide in combination with vandetanib (100 mg daily) or a placebo for up to 4 total cycles (no maintenance therapy)...
September 1, 2016: Cancer
https://www.readbyqxmd.com/read/27135215/a-microrna-switch-regulates-the-rise-in-hypothalamic-gnrh-production-before-puberty
#2
Andrea Messina, Fanny Langlet, Konstantina Chachlaki, Juan Roa, Sowmyalakshmi Rasika, Nathalie Jouy, Sarah Gallet, Francisco Gaytan, Jyoti Parkash, Manuel Tena-Sempere, Paolo Giacobini, Vincent Prevot
A sparse population of a few hundred primarily hypothalamic neurons forms the hub of a complex neuroglial network that controls reproduction in mammals by secreting the 'master molecule' gonadotropin-releasing hormone (GnRH). Timely postnatal changes in GnRH expression are essential for puberty and adult fertility. Here we report that a multilayered microRNA-operated switch with built-in feedback governs increased GnRH expression during the infantile-to-juvenile transition and that impairing microRNA synthesis in GnRH neurons leads to hypogonadotropic hypogonadism and infertility in mice...
June 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/25605863/clinical-cancer-advances-2015-annual-report-on-progress-against-cancer-from-the-american-society-of-clinical-oncology
#3
REVIEW
Gregory A Masters, Lada Krilov, Howard H Bailey, Marcia S Brose, Harold Burstein, Lisa R Diller, Don S Dizon, Howard A Fine, Gregory P Kalemkerian, Mark Moasser, Michael N Neuss, Steven J O'Day, Olatoyosi Odenike, Charles J Ryan, Richard L Schilsky, Gary K Schwartz, Alan P Venook, Sandra L Wong, Jyoti D Patel
No abstract text is available yet for this article.
March 1, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/25486501/managing-localized-unresectable-hepatocellular-carcinoma
#4
Jyoti Narang-Master, Denise Rizzolo
Hepatocellular carcinoma is becoming more common, and numerous treatment algorithms are available for this complex disease. This article reviews screening, diagnosis, staging, and management of hepatocellular carcinoma, including various treatments for patients who are not candidates for surgical resection and transplantation.
January 2015: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/25054332/vibrio-cholerae-utilizes-direct-srna-regulation-in-expression-of-a-biofilm-matrix-protein
#5
Tianyan Song, Dharmesh Sabharwal, Jyoti Mohan Gurung, Andrew T Cheng, Annika E Sjöström, Fitnat H Yildiz, Bernt Eric Uhlin, Sun Nyunt Wai
Vibrio cholerae biofilms contain exopolysaccharide and three matrix proteins RbmA, RbmC and Bap1. While much is known about exopolysaccharide regulation, little is known about the mechanisms by which the matrix protein components of biofilms are regulated. VrrA is a conserved, 140-nt sRNA of V. cholerae, whose expression is controlled by sigma factor σE. In this study, we demonstrate that VrrA negatively regulates rbmC translation by pairing to the 5' untranslated region of the rbmC transcript and that this regulation is not stringently dependent on the RNA chaperone protein Hfq...
2014: PloS One
https://www.readbyqxmd.com/read/24327669/clinical-cancer-advances-2013-annual-report-on-progress-against-cancer-from-the-american-society-of-clinical-oncology
#6
Jyoti D Patel, Lada Krilov, Sylvia Adams, Carol Aghajanian, Ethan Basch, Marcia S Brose, William L Carroll, Marcos de Lima, Mark R Gilbert, Mark G Kris, John L Marshall, Gregory A Masters, Steven J O'Day, Blasé Polite, Gary K Schwartz, Sunil Sharma, Ian Thompson, Nicholas J Vogelzang, Bruce J Roth
Since its founding in 1964, the American Society of Clinical Oncology (ASCO) has been committed to improving cancer outcomes through research and the delivery of quality care. Research is the bedrock of discovering better treatments--providing hope to the millions of individuals who face a cancer diagnosis each year. The studies featured in "Clinical Cancer Advances 2013: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology" represent the invaluable contributions of thousands of patients who participate in clinical trials and the scientists who conduct basic and clinical research...
January 10, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/22560880/a-novel-role-for-tpx2-as-a-scaffold-and-co-activator-protein-of-the-chromosomal-passenger-complex
#7
Jyoti Iyer, Ming-Ying Tsai
Aurora B kinase forms the enzymatic core of the Chromosomal Passenger Complex (CPC) and is a master regulator of mitosis. Understanding the regulation of Aurora B is critical to illuminate its role in mitosis. INCENP, Survivin and Borealin have all been known to promote Aurora B activation. In this study, we have identified the Aurora A activator protein TPX2 as a novel scaffold and co-activator protein of the CPC. Studies utilizing M-phase Xenopus egg extracts (XEE) revealed that the immunodepletion of endogenous TPX2 from XEE decreases Aurora B-Survivin and Aurora B-INCENP interactions, leading to a consequent reduction in Aurora B activity...
August 2012: Cellular Signalling
https://www.readbyqxmd.com/read/22147736/clinical-cancer-advances-2011-annual-report-on-progress-against-cancer-from-the-american-society-of-clinical-oncology
#8
Nicholas J Vogelzang, Steven I Benowitz, Sylvia Adams, Carol Aghajanian, Susan Marina Chang, Zoann Eckert Dreyer, Pasi A Janne, Andrew H Ko, Greg A Masters, Olatoyosi Odenike, Jyoti D Patel, Bruce J Roth, Wolfram E Samlowski, Andrew D Seidman, William D Tap, Jennifer S Temel, Jamie H Von Roenn, Mark G Kris
A message from ASCO'S President. It has been forty years since President Richard Nixon signed the National Cancer Act of 1971, which many view as the nation's declaration of the "War on Cancer." The bill has led to major investments in cancer research and significant increases in cancer survival. Today, two-thirds of patients survive at least five years after being diagnosed with cancer compared with just half of all diagnosed patients surviving five years after diagnosis in 1975. The research advances detailed in this year's Clinical Cancer Advances demonstrate that improvements in cancer screening, treatment, and prevention save and improve lives...
January 1, 2012: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/18215272/pleiotropic-phenotypes-of-a-yersinia-enterocolitica-flhd-mutant-include-reduced-lethality-in-a-chicken-embryo-model
#9
Megan K Townsend, Nathan J Carr, Jyoti G Iyer, Shelley M Horne, Penelope S Gibbs, Birgit M Prüss
BACKGROUND: The Yersinia enterocolitica flagellar master regulator FlhD/FlhC affects the expression levels of non-flagellar genes, including 21 genes that are involved in central metabolism. The sigma factor of the flagellar system, FliA, has a negative effect on the expression levels of seven plasmid-encoded virulence genes in addition to its positive effect on the expression levels of eight of the flagellar operons. This study investigates the phenotypes of flhD and fliA mutants that result from the complex gene regulation...
2008: BMC Microbiology
https://www.readbyqxmd.com/read/15155667/the-vibrio-cholerae-toxr-regulated-porin-ompu-confers-resistance-to-antimicrobial-peptides
#10
Jyoti Mathur, Matthew K Waldor
BPI (bactericidal/permeability-increasing) is a potent antimicrobial protein that was recently reported to be expressed as a surface protein on human gastrointestinal tract epithelial cells. In this study, we investigated the resistance of Vibrio cholerae, a small-bowel pathogen that causes cholera, to a BPI-derived peptide, P2. Unlike in Escherichia coli and Salmonella enterica serovar Typhimurium, resistance to P2 in V. cholerae was not dependent on the BipA GTPase. Instead, we found that ToxR, the master regulator of V...
June 2004: Infection and Immunity
https://www.readbyqxmd.com/read/12008759/robot-assisted-laparoscopic-heller-s-cardiomyotomy
#11
Jyoti Shah, Tim Rockall, Ara Darzi
There are many options available for the management of achalasia. Recently, the list of options has expanded to include robotic-assisted Heller's cardiomyotomy. In this article, we describe the procedure for a robotic-assisted cardiomyotomy and discuss the advantages of using a robotic, master-slave system.
February 2002: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
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