Franziska Briest, Daniel Noerenberg, Cornelius Hennch, Kenichi Yoshida, Raphael Hablesreiter, Jose Nimo, Daniel Sasca, Marieluise Kirchner, Larry Mansouri, Yoshikage Inoue, Laura Wiegand, Annette M Staiger, Beatrice Casadei, Penelope Korkolopoulou, January Weiner, Armando Lopez-Guillermo, Arne Warth, Tamás Schneider, Ákos Nagy, Wolfram Klapper, Michael Hummel, George Kanellis, Ioannis Anagnostopoulos, Philipp Mertins, Lars Bullinger, Richard Rosenquist, Theodoros P Vassilakopoulos, German Ott, Seishi Ogawa, Frederik Damm
Recent exome-wide studies discovered frequent somatic mutations in the epigenetic modifier ZNF217 in primary mediastinal B cell lymphoma (PMBCL) and related disorders. As functional consequences of ZNF217 alterations remain unknown, we comprehensively evaluated their impact in PMBCL. Targeted sequencing identified genetic lesions affecting ZNF217 in 33% of 157 PMBCL patients. Subsequent gene expression profiling (n = 120) revealed changes in cytokine and interferon signal transduction in ZNF217-aberrant PMBCL cases...
August 30, 2023: Leukemia