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Orrin Devinsky, Anthony Kim, Daniel Friedman, Annie Bedigian, Ellen Moffatt, Zian H Tseng
OBJECTIVE: Since cardic fibrosis was previously found more frequently in patients with sudden unexpected death in epilepsy (SUDEP) than control cases, we compared blinded and quantitative reviews of cardiac pathology in SUDEP to multiple control groups. METHODS: We adjudicated causes of death in epilepsy patients as part of consecutive out-of-hospital sudden cardiac deaths (SCDs) from the Postmortem Systematic Investigation of Sudden Cardiac Death (POSTSCD) study...
June 1, 2018: Neurology
Enisa Hodzic
Introduction: Ischemic heart disease (IHD) is clinical manifestation of chronic inflammatory progressive pathological process of atherosclerosis in coronary arteries. IHD is the leading cause of morbidity and mortality in the world. The question is whether it is possible to improve and direct the therapeutic treatment of IHD patients in the treatment of the inflammatory process in the atherosclerotic leasions. Material and Methods: A prospective, comparative, analytica,clinically applicable, open-type study was performed...
April 2018: Medical Archives
Mengliu Zeng, Wanzhen Jiang, Youjia Tian, Jie Hao, Zhenzhen Cao, Zhipei Liu, Chen Fu, Peihua Zhang, Jihua Ma
Andrographolide has a protective effect on the cardiovascular system. To study its cardic-electrophysiological effects, action potentials and voltage-gated Na(+) (INa), Ca(2+) (ICaL), and K(+) (IK1, IKr, Ito and IKur) currents were recorded using whole-cell patch clamp and current clamp techniques. Additionally, the effects of andrographolide on aconitine-induced arrhythmias were assessed on electrocardiograms in vivo. We found that andrographolide shortened action potential duration and reduced maximum upstroke velocity in rabbit left ventricular and left atrial myocytes...
September 22, 2017: Oncotarget
Mengliu Zeng, Wanzhen Jiang, Youjia Tian, Jie Hao, Zhenzhen Cao, Zhipei Liu, Chen Fu, Peihua Zhang, Jihua Ma
Andrographolide has a protective effect on the cardiovascular system. To study its cardic-electrophysiological effects, action potentials and voltage-gated Na+ (INa), Ca2+ (ICaL), and K+ (IK1, IKr, Ito and IKur) currents were recorded using whole-cell patch clamp and current clamp techniques. Additionally, the effects of andrographolide on aconitine-induced arrhythmias were assessed on electrocardiograms in vivo. We found that andrographolide shortened action potential duration and reduced maximum upstroke velocity in rabbit left ventricular and left atrial myocytes...
May 22, 2017: Oncotarget
Santhakumari Nagothu Rajani, Yogananda Reddy Indla, R Archana, P Rajesh
According to International Diabetic Federation, type 2 diabetic population is on the rise globally and cognitive decline is one of the complications seen in type 2 diabetes. The present study is aimed at exploring the role of regular practice of yoga on cognition in type 2 diabetes and also to study the relation between the cognition and functional status of autonomic nervous system by considering the Cardiac Autonomic (CAN) function tests. Ten type 2 diabetic subjects of both the sex, aged between 35-55 years, who practiced yoga for a period of six months at Yogi Vemana Yoga Research Institute were recruited as test group...
November 2015: International Journal of Research in Ayurveda and Pharmacy
Nurhafizah Mahri, Kok Beng Gan, Mohd Alauddin Mohd Ali, Mohd Hasni Jaafar, Rusna Meswari
The risk of heart attack or myocardial infarction (MI) may lead to serious consequences in mortality and morbidity. Current MI management in the triage includes non-invasive heart monitoring using an electrocardiogram (ECG) and the cardic biomarker test. This study is designed to explore the potential of photoplethysmography (PPG) as a simple non-invasive device as an alternative method to screen the MI subjects. This study emphasises the usage of second derivative photoplethysmography (SDPPG) intervals as the extracted features to classify the MI subjects...
2016: Journal of Medical Engineering & Technology
Yingli Yu, Guibo Sun, Yun Luo, Min Wang, Rongchang Chen, Jingyi Zhang, Qidi Ai, Na Xing, Xiaobo Sun
BACKGROUND: Recent reports suggested the involvement of oxidative stress- and endoplasmic reticulum stress (ERS)-associated pathways in the progression of ischemia/reperfusion (I/R) injury. Notoginsenoside R1 (NGR1) is a novel saponin isolated from P. notoginseng, which has a history of prevention and treatment of cardiovascular diseases. OBJECTIVE: We aimed to examine the cardioprotective effects of NGR1 on I/R-induced heart dysfunction ex vivo and in vitro. METHODS: H9c2 cadiomyocytes were incubated with NGR1 for 24 h and exposed to hypoxia/reoxygenation...
February 18, 2016: Scientific Reports
Li Sun, Xin He, Juan Wang, Bimei Jiang, Zhongyi Tong, Yanjuan Liu, Yuanbin Li, Xianzhong Xiao
OBJECTIVE: To investigate the nucleolus expression in the diabetic cardiomyopathy. METHODS: The rats were divided into a control group and a type II diabetic cardiomyopathy group (model group). In the model group, rats were fed with high-fat and high-sugar food (rats were intravenously injected with 60 mg/kg chain urea with cephalosporins in the 5th and 6th weeks in mice). The level of blood glucose was determined at the end of 8th week and the level of fasting blood glucose was examined at the end of 20th week...
October 2014: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Yong Xiao, Zeng-chun Ma, Yu-guang Wang, Hong-ling Tan, Xiang-ling Tang, Qian-de Liang, Cheng-rong Xiao, Yue Gao
OBJECTIVE: To evaluate whether Shenfu injection (SFI) protects against cardiac myocyte injury induced by Fupian injection (FPI) in vitro. METHODS: H9c2 cells were separately treated with FPI, Renshen injection (RSI) and SFI. Cell viability, lactate dehydrogenase (LDH) release, spontaneous beating rate of primative cardical cells, caspase-3/7 activity, cell apoptosis, and cytochrome P450 2J3 (CYP2J3) mRNA expression were analyzed. RESULTS: The viability of H9c2 cells treated with SFI (37 and 75 mg/mL) was significantly higher than that of H9c2 cells treated with FPI (25 and 50 mg/mL) (P<0...
September 2013: Journal of Integrative Medicine
Qiang Liu, Xiao-jia Su, Yan Yu, Yong-lin Liu
In our study, 50 patients with dilated cardiomyopathy (DCM) were selected to investigate the correlation between virus persistent infection and cardic function. We found that 44% of patients with DCM were coxsackie virus B-RNA (CVB-RNA) positive, significantly different from that (20%) of the normal control group (P<0.05). The expression levels of coxsackie adenovirus receptor (CAR) in patients with DCM were significantly higher than those in the normal control group (P<0.01). In CVB-RNA-positive patients, expression levels of CAR were significantly higher than those in CVB-RNA-negative patients (P<0...
August 2013: Journal of Zhejiang University. Science. B
Xule Wang, Qingyan Zhao, He Huang, Yanhong Tang, Jinping Xiao, Zixuan Dai, Shengbo Yu, Congxin Huang
We have previously demonstrated that catheter-based renal sympathetic denervation (RSD) could suppress atrial fibrillation (AF) in canines with short-time rapid right atrial pacing (RAP). However, the role of renal denervation on atrial remodeling is unclear. The aim of the present study was to explore the long-term effect of RSD on the atrial remodeling during prolonged RAP. Twenty mongrel dogs were implanted with a high-frequency cardiac pacemaker with a transvenous lead inserted into the right atrial appendage...
2013: PloS One
Emmanouil D Zacharakis, Stylianos N Kounalakis, George P Nassis, Nickos D Geladas
The progressive heart rate (HR) increase and stroke volume (SV) decline during prolonged constant-load leg exercise signifies cardiovascular drift (CVdrift); fluid replacement is known to minimize this phenomenon. Like their able-bodied counterparts (AB), paraplegic athletes undergo prolonged exercise during training and competition, which could result in CVdrift. The aim of this study is to address the role of rehydration on preventing CVdrift in spinal cord injured (SCI) paraplegic athletes. Eight SCI athletes with an injury level between C7 and T6 and 9 AB subjects performed 60-min constant-load exercise on a wheelchair ergometer in a thermo-neutral environment...
April 2013: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Perlat Kapisyzi, Dhimitraq Argjiri, Loreta Bica, Jola Klosi, Anila Aliko, Jeta Beli, Ylli Vakeffliu, Roland Kore, Elenka Shehu, Ornela Nuredini, Mirela Tabaku, Epaminonda Fype
SESSION TYPE: COPD Posters IPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: The aim of the study was to evaluate the correlation between gravity of COPD and PH as a complication.METHODS: A total of 44 hospitalised patients enrolled in the study. The diagnose of PH was made using standard clinical, echorgaphic and thoracic CT. The classification of COPD was made according GOLDRESULTS: Mean age of patients enrolled in study was 70.4 ± 7.96, smokers were 35 (79%) patients. Thirty eight (87...
October 1, 2012: Chest
Malcon Andrei Martinez-Pereira, Raphaela da Cunha Franceschi, Graziane de Freitas Antunes, Bárbara Paranhos Coelho, Matilde Achaval, Denise M Zancan
We describe the morphology and innervation of the midgut and hindgut of the giant land snail Megalobulimus abbreviatus for the first time. The midgut (stomach and intestine) and hindgut (rectum and anus) are innervated by the subesophageal ganglia, through the gastrointestinal branch (originated from the visceral nerve) and the rectum-anal nerve, respectively. Backfilling through these nerves revealed neuronal bodies, mainly in the right parietal and visceral ganglia. The enteric plexuses of the midgut and hindgut are formed by extensive axonal networks and several neuronal somata arranged in clusters or as isolated cells...
April 2013: Zoological Science
A C Roy, S R Park, D Cunningham, Y K Kang, Y Chao, L T Chen, C Rees, H Y Lim, J Tabernero, F J Ramos, M Kujundzic, M B Cardic, C G Yeh, A de Gramont
BACKGROUND: PEP02 is a novel highly stable liposomal nanocarrier formulation of irinotecan. This randomized phase II study evaluated the efficacy and safety of single agent PEP02 compared with irinotecan or docetaxel in the second-line treatment of advanced oesophago-gastric (OG) cancer. PATIENTS AND METHODS: Patients with locally advanced/metastatic disease who had failed one prior chemotherapy regimen were randomly assigned to PEP02 120 mg/m(2), irinotecan 300 mg/m(2) or docetaxel (Taxotere) 75 mg/m(2) every 3 weeks...
June 2013: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Fred S Apple, Ranka Ler, MaryAnn M Murakami
BACKGROUND: Between-assay comparability of 99th percentiles for cardiac troponin concentrations has not been assessed systematically in a single population for a large number of assays. METHODS: We determined 99th percentiles for 19 cardiac troponin assays in heparin plasma samples from a population of 272 and 252 presumably healthy males and females, respectively. The assays evaluated included 1 cardiac troponin T (cTnT) assay from Roche and 18 cTnI assays from Abbott, Alere, Beckman, bioMerieux, Instrumentation Laboratory, Ortho-Clinical Diagnostics, Singulex, Siemens, and Roche...
November 2012: Clinical Chemistry
Hong Zheng, Hai Guo, Jian-rong Ye, Lin Chen
OBJECTIVE: To develop and evaluate an individualized fluid therapy in the elderly patients with coronary heart disease undergoing gastrointestinal surgery. METHODS: In this prospective study, 60 coronary heart disease patients undergoing gastrointestinal surgery were included in the First Affiliated Hospital of Xinjiang Medical University from March 2009 to March 2012. Patients were randomized into the intervention group and the control group with 30 patients in each group...
June 2012: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Barbara Da Silva, Jean Tschampa, Jörg Beron, Linda Fredrick, Meenal Patwardhan, Woodie Zachry, William C Woodward, Michael Norton, Angela Nilius
OBJECTIVE: There is growing interest in studying age-related diseases, such as coronary artery disease (CAD) and resulting myocardial infarction (MI) in HIV-infected patients. While some cohort studies indicate that several antiretrovirals (ARVs), including the protease inhibitor lopinavir/ ritonavir (LPV/r), are associated with an increased relative risk (RR) of MI, other studies show a reduction of MI and CAD in subjects taking ARVs when compared with HIV+ patients not taking ARV therapy...
June 2012: International Journal of Clinical Pharmacology and Therapeutics
Min Qian, Yan Meng, Lin Zhai, Rong Zheng, Lan Zhang
OBJECTIVE: To explore the characteristics of endocardiac and extracardiac haemodynamics parameters in fetus with thickened nuchal translucency (NT) and analyze the relationship between hemodynamic changes and fetal prognosis. METHODS: The fetal appearance was observed during the first trimester. And the thickness of NT or soft tissue of neck was quantified. The endocardiac and extracardiac haemodynamic parameters were measured by ultrasound Doppler. The parameters were compared between fetus with thickened NT and normal fetus...
January 3, 2012: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Huixian Zheng, Yanling Chen, Jin Chen, Joey Kwong, Wenmei Xiong
BACKGROUND: Heart failure is a major public health problem worldwide. Shengmai (a traditional Chinese herbal medicine) has long been used as a complementary treatment for heart failure in China. OBJECTIVES: To determine the effects (both benefits and harms) of Shengmai plus usual treatment versus usual treatment alone for heart failure. SEARCH STRATEGY: We searched CENTRAL and DARE on The Cochrane Library (Issue 3, 2008), MEDLINE (1966 to August 2008), EMBASE (1984 to August 2008), AMED (1985 to August 2008) and BIOSIS (1997 to August 2008) and CBM (1978 to August 2008)...
2011: Cochrane Database of Systematic Reviews
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