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https://www.readbyqxmd.com/read/29447228/chromosomal-distribution-of-pta-535-pta-86-pta-713-35s-rdna-repetitive-sequences-in-interspecific-hexaploid-hybrids-of-common-wheat-triticum-aestivum-l-and-spelt-triticum-spelta-l
#1
Klaudia Goriewa-Duba, Adrian Duba, Michał Kwiatek, Halina Wiśniewska, Urszula Wachowska, Marian Wiwart
Fluorescent in situ hybridization (FISH) relies on fluorescent-labeled probes to detect specific DNA sequences in the genome, and it is widely used in cytogenetic analyses. The aim of this study was to determine the karyotype of T. aestivum and T. spelta hybrids and their parental components (three common wheat cultivars and five spelt breeding lines), to identify chromosomal aberrations in the evaluated wheat lines, and to analyze the distribution of polymorphisms of repetitive sequences in the examined hybrids...
2018: PloS One
https://www.readbyqxmd.com/read/29434807/influence-of-sevoflurane-exposure-on-mitogen-activated-protein-kinases-and-akt-gsk-3%C3%AE-crmp-2-signaling-pathways-in-the-developing-rat-brain
#2
Yafang Liu, Chuiliang Liu, Minting Zeng, Xue Han, Kun Zhang, Yanni Fu, Jue Li, Yujuan Li
Prolonged exposure to volatile anesthetics causes neurodegeneration in developing animal brains. However, their underlying mechanisms of action remain unclear. The current study investigated the expression of proteins associated with the mitogen-activated protein kinases (MAPK) and protein kinase B (Akt)/glycogen synthase kinase-3β (GSK-3β)/collapsin response mediator protein 2 (CRMP-2) signaling pathways in the cortices of neonatal mice following exposure to sevoflurane. Seven-day-old (P7) neonatal C57BL/6 mice were randomly divided into 2 groups and either exposed to 2...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433858/hearing-loss-in-type-2-diabetes-in-association-with-diabetic-neuropathy
#3
Huihui Ren, Zhenggang Wang, Zhongyao Mao, Ping Zhang, Chunfang Wang, Aiguo Liu, Gang Yuan
BACKGROUND: Reports assessing hearing abnormalities in diabetes are debated. We aimed to evaluated auditory alterations and their possible associations with vascular and neurological dysfunction in 160 Type 2 diabetes mellitus individuals and 100 age and sex-matched healthy controls. METHODS: Participants underwent pure tone audiometry (PTA). Associations with demographic, metabolic and neuropathic variables were assessed. RESULTS: Compared with healthy controls, diabetic patients had higher mean hearing thresholds at each frequency, with statistical significance at 2-8 kHz (p <0...
February 9, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29430506/toward-personalised-liquid-biopsies-for-urothelial-carcinoma-characterisation-of-ddpcr-and-urinary-cfdna-for-the-detection-of-the-tert-228%C3%A2-g-a-t-mutation
#4
Ilaria J Russo, Yongwon Ju, Naheema S Gordon, Maurice P Zeegers, K K Cheng, Nicholas D James, Richard T Bryan, Douglas G Ward
Background: TERT promotor mutations are present in >75% of bladder tumours; these mutations are also detectable in urine. Previous studies have used urinary pellet DNA, and semi-quantitative methods unsuitable for detecting very low mutant allele frequencies. Objective: In this proof-of-principle study we use ddPCR to count the DNA molecules with wt and mutant TERT sequences in urinary cfDNA from patients whose bladder cancers harbour TERT mutations. Methods: Urinary cfDNA prepared from the urine from 104 bladder cancer patients was analysed...
January 20, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29426271/long-term-results-of-atresiaplasty-in-patients-with-congenital-aural-atresia
#5
Juuso Pellinen, Juha-Pekka Vasama, Ilkka Kivekäs
OBJECTIVES: To evaluate long-term benefits of atresiaplasty on hearing and the impact of surgery on quality of life (QoL) in congenital aural atresia (CAA) patients. METHODS: We evaluated the long-term hearing results, the impact of atresiaplasty on QoL, the meatal diameter of the operated ear canal, and the cumulative number of post-operative hospital visits in 14 CAA patients, on average, 12 years (range: 4-17 years) post-operatively. RESULTS: The mean preoperative pure tone average (PTA) was 61 dB HL...
February 9, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29425191/effect-of-the-composition-of-lanthanide-complexes-on-their-luminescence-enhancement-by-ag-sio%C3%A2-core-shell-nanoparticles
#6
Xiao-Jing Wang, Yan-Rong Qu, Yong-Liang Zhao, Hai-Bin Chu
Metal-enhanced luminescence of lanthanide complexes by noble metal nanoparticles has attracted much attention because of its high efficiency in improving the luminescent properties of lanthanide ions. Herein, nine kinds of europium and terbium complexes-RE(TPTZ)(ampca)₃·3H₂O, RE(TPTZ)(BA)₃·3H₂O, RE(phen)(ampca)₃·3H₂O, RE(phen)(PTA)1.5·3H₂O (RE = Eu, Tb) and Eu(phen)(BA)₃·3H₂O (TPTZ = 2,4,6-tri(2-pyridyl)-s-triazine, ampca = 3-aminopyrazine-2-carboxylic acid, BA = benzoic acid, phen = 1,10-phenanthroline, PTA = phthalic acid)-have been synthesized...
February 9, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29424253/molecular-hydrogen-upregulates-heat-shock-response-and-collagen-biosynthesis-and-downregulates-cell-cycles-%C3%A2-meta-analyses-of-gene-expression-profiles
#7
Hiroshi Nishiwaki, Mikako Ito, Shuto Negishi, Sayaka Sobue, Masatoshi Ichihara, Kinji Ohno
BACKGROUND: Molecular hydrogen exerts its effect on multiple pathologies, including oxidative stress, inflammation, and apoptosis. However, its molecular mechanisms have not been fully elucidated. In order to explore the effects of molecular hydrogen, we meta-analyzed gene expression profiles modulated by molecular hydrogen. METHODS: We performed microarray analysis of the mouse liver with or without drinking hydrogen water. We also integrated two previously reported microarray datasets of the rat liver into meta-analyses...
February 9, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29423838/evaluating-displacement-of-lamina-cribrosa-following-glaucoma-surgery
#8
Patrycja Krzyżanowska-Berkowska, Aleksandra Melińska, Iwona Helemejko, D Robert Iskander
PURPOSE: The purpose of the study is to assess the displacement of lamina cribrosa (LC) and prelaminar tissue area (PTA) changes following trabeculectomy and non-penetrating deep sclerectomy (NPDS) using spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging technology. METHODS: A total of 30 patients underwent glaucoma surgery. Sixteen patients underwent trabeculectomy, and 14 patients undertook NPDS. Serial horizontal B-scan images of optic nerve head (ONH) were obtained using SD-OCT preoperatively, and at 2-week, 1-, 3-, and 6-month postoperative visit (6 pv)...
February 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29411117/computer-tomography-based-morphometric-analysis-of-the-cervical-spine-pedicles-c3-c7
#9
Leonard Westermann, Carolin Spemes, Peer Eysel, Marvin Simons, Max J Scheyerer, Jan Siewe, Dominik Baschera
BACKGROUND: Our aim was to examine the specific dimensions of cervical pedicles in a large Caucasian cohort on high dissolving CT scans. METHODS: A retrospective analysis of 100 cervical spine CT scans with a maximum slice thickness of 1 mm in axial, sagittal, and coronal reconstructions was performed. The pedicle axial length (PAL), inner and outer pedicle diameter (IPD/OPD), pedicle sagittal and transverse angle (PSA/PTA), pedicle height (PH), pedicle width (PW), and the cortical thickness (COT) at different margins were measured by two independent observers...
February 6, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29400569/the-value-of-the-identification-of-predisposing-factors-for-post-traumatic-amnesia-in-management-of-mild-traumatic-brain-injury
#10
George Fotakopoulos, Demosthenes Makris, Eleni Tsianaka, Polikceni Kotlia, Paulos Karakitsios, Charalabos Gatos, Alkiviadis Tzannis, Kostas Fountas
OBJECT: To identify the risk factors for post-traumatic amnesia (PTA) and to document the incidence of PTA after mild traumatic brain injuries. METHODS: This was a prospective study, affecting mild TBI (mTBI) (Glasgow Coma Scale 14-15) cases attending to the Emergency Department between January 2009 and April 2012 (40 months duration). Patients were divided into two groups (Group A: without PTA, and Group B: with PTA, and they were assessed according to the risk factors...
February 5, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29390288/intratympanic-glucocorticosteroid-therapy-for-idiopathic-sudden-hearing-loss-meta-analysis-of-randomized-controlled-trials
#11
Dan Lai, Fei Zhao, Nasim Jalal, Yun Zheng
BACKGROUND AND OBJECTIVE: Glucocorticoids are the standard treatment for idiopathic sudden sensorineural hearing loss (ISSNHL), but whether intratympanic or systemic therapy is superior remains controversial. Previous meta-analyses of this question have omitted key clinical trials or included observational studies. METHODS: English-language randomized controlled trials in OvidSP, PubMed, Embase, CINAHL, and the Cochrane Library comparing intratympanic versus systemic glucocorticoid therapy for ISSNHL were meta-analyzed using RevMan 5...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390277/a-rare-case-report-of-bilateral-common-and-internal-iliac-arterial-fibromuscular-dysplasia-coexisted-dissection-aneurysm-and-stenosis
#12
Luyun Fan, Wenjun Ma, Huimin Zhang, Jun Cai
RATIONALE: Iliac arterial fibromuscular dysplasia (FMD) was rarely reported and its demographic, clinical, and imaging features have not been precisely described resulting in uncertain therapeutic methods. PATIENT CONCERNS: A 31-year-old man was referred because of 3-month-ago onset hypertension, low serum potassium, and a small-sized right kidney with normal renal artery under ultrasound examination. This patient was suspected of primary aldosteronism, whereas spirolactone was poorly effective...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383315/methylprednisolone-versus-dexamethasone-for-control-of-vertigo-in-patients-with-definite-meniere-s-disease
#13
Elham Masoumi, Sasan Dabiri, Mohammad Taghi Khorsandi Ashtiani, Reza Erfanian, Saeed Sohrabpour, Nasrin Yazdani, Alireza Safaee, Mohammadreza Firouzifar
Introduction: Definite Meniere's disease is associated with two or more definitive periods of vertigo along with hearing loss, plus tinnitus or aural fullness or both. This study aimed to compare the effect of intratympanic dexamethasone and methylprednisolone on the functional-level scale of pure-tone audiometry (PTA), and class outcome measures of vertigo. Materials and Methods: In this clinical study, 69 patients with definite Meniere's disease, referred to the tertiary otolaryngology center, were randomly assigned to two groups: 36 patients were treated with intratympanic dexamethasone (4mg/dl) and 33 patients were treated with i ntratympanic methylprednisolone (40mg/dl)...
November 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29383077/development-of-a-novel-ultrasound-guided-peritonsillar-abscess-model-for-simulation-training
#14
Vivienne Ng, Jennifer Plitt, David Biffar
Introduction: Peritonsillar abscess (PTA) is the most common deep space infection of the head and neck presenting to emergency departments.1 No commercial PTA task trainer exists for simulation training. Thus, resident physicians often perform their first PTA needle aspiration in the clinical setting, knowing that carotid artery puncture and hemorrhage are serious and devastating complications. While several low-fidelity PTA task trainers have been previously described, none allow for ultrasound image acquisition...
January 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29382394/pharmacokinetics-of-meropenem-in-septic-patients-on-sustained-low-efficiency-dialysis-a-population-pharmacokinetic-study
#15
Stephan Braune, Christina König, Jason A Roberts, Axel Nierhaus, Oliver Steinmetz, Michael Baehr, Stefan Kluge, Claudia Langebrake
BACKGROUND: The aim of the study was to describe the population pharmacokinetics (PK) of meropenem in critically ill patients receiving sustained low-efficiency dialysis (SLED). METHODS: Prospective population PK study on 19 septic patients treated with meropenem and receiving SLED for acute kidney injury. Serial blood samples for determination of meropenem concentrations were taken before, during and after SLED in up to three sessions per patient. Nonparametric population PK analysis with Monte Carlo simulations were used...
January 30, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29381705/prediction-of-reaction-knockouts-to-maximize-succinate-production-by-actinobacillus-succinogenes
#16
Ambarish Nag, Peter C St John, Michael F Crowley, Yannick J Bomble
Succinate is a precursor of multiple commodity chemicals and bio-based succinate production is an active area of industrial bioengineering research. One of the most important microbial strains for bio-based production of succinate is the capnophilic gram-negative bacterium Actinobacillus succinogenes, which naturally produces succinate by a mixed-acid fermentative pathway. To engineer A. succinogenes to improve succinate yields during mixed acid fermentation, it is important to have a detailed understanding of the metabolic flux distribution in A...
2018: PloS One
https://www.readbyqxmd.com/read/29379142/erythrocyte-folate-serum-vitamin-b12-and-hearing-loss-in-the-2003-2004-national-health-and-nutrition-examination-survey-nhanes
#17
Edmond K Kabagambe, Loren Lipworth, Robert F Labadie, Linda J Hood, David O Francis
BACKGROUND/OBJECTIVES: Studies based on food frequency questionnaires suggest that folate and vitamin B12 intake could protect against hearing loss. We investigated whether erythrocyte folate and serum vitamin B12 levels are independently associated with hearing loss in humans. SUBJECTS/METHODS: Participants in the 2003-2004 US National Health and Nutrition Examination Survey who had data on hearing, folate, and vitamin B12 levels were included. Pure-tone average (PTA) at 0...
January 29, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29378569/synthesis-of-4-dimethylamino-pyridine-propylthioacetate-coated-gold-nanoparticles-and-their-antibacterial-and-photophysical-activity
#18
Ayaz Anwar, Sadia Khalid, Samina Perveen, Shakil Ahmed, Ruqaiyyah Siddiqui, Naveed Ahmed Khan, Muhammad Raza Shah
BACKGROUND: Gold nanoparticles are useful candidate for drug delivery applications and are associated with enhancement in the bioavailability of coated drugs and/or therapeutic agent. Since, heterocyclic compounds are known to exhibit antimicrobial potential against variety of pathogens, we designed this study to evaluate the antibacterial effects of gold nanoparticles conjugation with new synthesized cationic ligand; 4-Dimethyl aminopyridinium propylthioacetate (DMAP-PTA) in comparison with pure compound and antibiotic drug Pefloxacin...
January 29, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29377998/exploring-colistin-pharmacodynamics-against-klebsiella-pneumoniae-a-need-to-revise-current-susceptibility-breakpoints
#19
Marilena Tsala, Sophia Vourli, Panagiota-Christina Georgiou, Spyros Pournaras, Athanasios Tsakris, George L Daikos, Johan W Mouton, Joseph Meletiadis
Objectives: Because the pharmacokinetic/pharmacodynamic (PK/PD) characteristics of colistin against Enterobacteriaceae are not well explored, we studied the activity of colistin against K. pneumoniae in an in vitro PK/PD model simulating different dosing regimens. Methods: Three clinical isolates of K. pneumoniae with MICs of 0.5, 1 and 4 mg/L were tested in an in vitro PK/PD model following a dose-fractionation design over a period of 24 h. A high and low inoculum of 107 and 104 cfu/mL with and without a heteroresistant subpopulation, respectively, were used...
January 25, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29377901/long-term-effects-of-pancreas-transplant-alone-on-nephropathy-in-type-1-diabetic-patients-with-optimal-renal-function
#20
Sung Shin, Chang Hee Jung, Ji Yoon Choi, Hyun Wook Kwon, Joo Hee Jung, Young Hoon Kim, Duck Jong Han
BACKGROUND: Limited data are available regarding optimal selection criteria for pancreas transplant alone (PTA) to minimize aggravation of diabetic nephropathy. METHODS: A total of 87 type 1 diabetic patients were evaluated before and after PTA at a single center from January, 1999 to December, 2015, together with 87 matched non-transplanted type 1 diabetic subjects who were candidates for PTA to compare deterioration of native kidney function. A total of 163 patients (79 in the transplanted group and 84 in the nontransplanted group) were finally enrolled after excluding nine patients with estimated glomerular filtration rate less than 60 mL/min/1...
2018: PloS One
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