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https://www.readbyqxmd.com/read/27933063/aire-downregulation-is-associated-with-changes-in-the-posttranscriptional-control-of-peripheral-tissue-antigens-in-medullary-thymic-epithelial-cells
#1
Ernna H Oliveira, Claudia Macedo, Cristhianna V Collares, Ana Carolina Freitas, Paula Barbim Donate, Elza T Sakamoto-Hojo, Eduardo A Donadi, Geraldo A Passos
Autoimmune regulator (Aire) is a transcriptional regulator of peripheral tissue antigens (PTAs) and microRNAs (miRNAs) in medullary thymic epithelial cells (mTECs). In this study, we tested the hypothesis that Aire also played a role as an upstream posttranscriptional controller in these cells and that variation in its expression might be associated with changes in the interactions between miRNAs and the mRNAs encoding PTAs. We demonstrated that downregulation of Aire in vivo in the thymuses of BALB/c mice imbalanced the large-scale expression of these two RNA species and consequently their interactions...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27931193/coagulase-negative-staphylococcal-sepsis-in-neonates-do-we-need-to-adapt-vancomycin-dose-or-target
#2
Helgi Padari, Kersti Oselin, Tõnis Tasa, Tuuli Metsvaht, Krista Lõivukene, Irja Lutsar
BACKGROUND: Despite differences in types of infection and causative organisms, pharmacokinetic-pharmacodynamic (PKPD) targets of vancomycin therapy derived from adult studies are suggested for neonates. We aimed to identify doses needed for the attainment of AUC/MIC > 400 and AUC/MIC > 300 in neonates with sepsis and correlate these targets with recommended doses and treatment outcome. METHODS: Neonates who had Vancomycin therapeutic drug monitoring (TDM) performed between January 1, 2010 and December 31, 2012 were studied...
December 8, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27929398/new-oligonucleotide-probes-for-nd-fish-analysis-to-identify-barley-chromosomes-and-to-investigate-polymorphisms-of-wheat-chromosomes
#3
Shuyao Tang, Ling Qiu, Zhiqiang Xiao, Shulan Fu, Zongxiang Tang
Oligonucleotide probes that can be used for non-denaturing fluorescence in situ hybridization (ND-FISH) analysis are convenient tools for identifying chromosomes of wheat (Triticum aestivum L.) and its relatives. New oligonucleotide probes, Oligo-HvT01, Oligo-pTa71-1, Oligo-s120.1, Oligo-s120.2, Oligo-s120.3, Oligo-275.1, Oligo-275.2, Oligo-k566 and Oligo-713, were designed based on the repetitive sequences HVT01, pTa71, pTa-s120, pTa-275, pTa-k566 and pTa-713. All these probes can be used for ND-FISH analysis and some of them can be used to detect polymorphisms of wheat chromosomes...
December 5, 2016: Genes
https://www.readbyqxmd.com/read/27921520/a-comparison-between-systemic-and-intratympanic-steroid-therapies-as-initial-therapy-for-idiopathic-sudden-sensorineural-hearing-loss-a-meta-analysis
#4
Qingfen Qiang, Xuewen Wu, Tao Yang, Chunguang Yang, Hong Sun
CONCLUSIONS: Intratympanic steroid (ITS) treatment groups exhibited better outcomes in PTA improvement and recovery rate than systemic steroid therapy (SST) groups. Whether initial hearing loss severity would influence the PTA improvement and recovery rate still requires further research. OBJECTIVE: This article was aimed at evaluating whether intratympanic steroid (ITS) treatment would provide benefits over systemic steroid therapy (SST) as initial therapy in patients with idiopathic sudden sensorineural hearing loss (ISSHL)...
December 6, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27918458/new-electrochemically-modified-carbon-paste-inclusion-%C3%AE-cyclodextrin-and-carbon-nanotubes-sensors-for-quantification-of-dorzolamide-hydrochloride
#5
Nawal Ahmad Alarfaj, Maha Farouk El-Tohamy
The present article introduces a new approach to fabricate carbon paste sensors, including carbon paste, modified carbon paste inclusion β-cyclodextrin, and carbon nanotubes for the quantification of dorzolamide hydrochloride (DRZ). This study is mainly based on the construction of three different carbon paste sensors by the incorporation of DRZ with phosphotungstic acid (PTA) to form dorzolamide-phosphotungstate (DRZ-PT) as an electroactive material in the presence of the solvent mediator ortho-nitrophenyloctyl ether (o-NPOE)...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27917796/does-tinnitus-lead-to-depression
#6
Esra Temugan, Rabia B Yildirım, Hümeyra Onat, Merve Susuz, Cemre Elden, Selim Unsal, Nebi Mustafa Gumus, Mesut Kaya
PURPOSE: The aim of the study was to investigate the correlation between THI (Tinnitus Handicap Inventory) and BDS (Beck Depression Scale). MATERIALS AND METHODS: High frequency thresholds and PTA (Pure Tone Audiometer) thresholds for the patients were measured in 44 patients with tinnitus (bilateral=13; unilateral=31). Tinnitus frequency and intensity were measured using one-pair method with high frequency audiometer Interacoustic AC40. Applied BDS and THI scores are evaluated for all patients...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27908309/an-unrecognised-presentation-of-takayasu-arteritis-superficial-femoral-artery-involvement
#7
Hui Dong, Wuqiang Che, Xiongjing Jiang, Meng Peng, Yubao Zou, Huimin Zhang, Bo Xu, Yuejin Yang, Runlin Gao
OBJECTIVES: Superficial femoral artery (SFA) involvement in Takayasu arteritis (TA) has rarely been reported. The purpose of this study was to investigate the clinical characteristic and clinical outcomes of endovascular therapy in such patients. METHODS: We analysed the data collected from 105 consecutive patients with TA, who were diagnosed from January 2011 to December 2013. All patients underwent ankle brachial index (ABI) measurements and angiography. Nine patients with an ABI <0...
November 18, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27906510/thermohydrogel-containing-melanin-for-photothermal-cancer-therapy
#8
Miri Kim, Hyun Soo Kim, Min Ah Kim, Hyanghwa Ryu, Hwan-Jeong Jeong, Chang-Moon Lee
Melanin is an effective absorber of light and can extend to near infrared (NIR) regions. In this study, a natural melanin is presented as a photothermal therapeutic agent (PTA) because it provides a good photothermal conversion efficiency, shows biodegradability, and does not induce long-term toxicity during retention in vivo. Poloxamer solution containing melanin (Pol-Mel) does not show any precipitation and shows sol-gel transition at body temperature. After irradiation from 808 nm NIR laser at 1.5 W cm(-2) for 3 min, the photothermal conversion efficiency of Pol-Mel is enough to kill cancer cells in vitro and in vivo...
December 1, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27905190/the-diagnostic-accuracy-of-non-imaging-screening-protocols-for-vestibular-schwannoma-in-patients-with-asymmetrical-hearing-loss-and-or-unilateral-audiovestibular-dysfunction-a-diagnostic-review-and-meta-analysis
#9
M Hentschel, M Scholte, S Steens, H Kunst, M Rovers
BACKGROUND: Currently, all patients presenting with asymmetrical sensorineural hearing loss and/or unilateral audiovestibular dysfunction (i.e. tinnitus, dizziness) undergo MRI, leading to a substantial amount of MRIs with negative findings as the incidence of vestibular schwannoma (VS) in this screening population varies between 1% and 4.7% (i.e. more than 95% of MRIs are negative for VS). OBJECTIVE OF REVIEW: The aim was to assess the diagnostic accuracy of different non-imaging screening protocols that can be used prior to MRI to select patients at high risk of VS...
November 5, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27903472/-endovascular-treatment-of-poplital-artery-aneurysms-a-word-of-caution-after-long-term-follow-up
#10
Cosimo Maraglino, Gianluca Canu, Renzo Ambrosi, Franco Briolini, Riccardo Gotti, Pietro Cefalì, Fabio Calliari, Paolo Ferrero, Franco Terraneo
PURPOSE: The aim of this work was to evaluate the long-term patency of endo-grafting in the treatment of popliteal artery aneurysms (Paa) and to identify which factors may be predictor of graft occlusion. METHODS: All the patients that underwent endovascular repair of Paa were analyzed from 2006 until 2014 on the basis of symptoms, comorbidities, limb salvage and long-term patency. The predictive value of the different variables was assessed in univariate analysis for primary patency and, for factors resulted significant, a multivariate analysis was performed...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27901490/prognostic-value-of-preoperative-plasma-fibrinogen-level-and-platelet-to-lymphocyte-ratio-f-plr-in-patients-with-localized-upper-tract-urothelial-carcinoma
#11
Jiwei Huang, Yichu Yuan, Yanqing Wang, Jin Zhang, Wen Kong, Haige Chen, Yonghui Chen, Yiran Huang
PURPOSE: Hemostatic factors is thought to have a potentially significant role in progression and metastasis of malignant tumors. We investigated the prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (PLR) in localized upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: A total of 481 patients who underwent radical nephroureterectomy for localized UTUC (pTa-4N0M0) were identified between January 2002 and June 2013...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901393/comparison-of-desired-radiographic-advancement-distance-and-true-advancement-distance-required-for-patellar-tendon-tibial-plateau-angle-reduction-to-the-ideal-90%C3%A2-in-dogs-by-use-of-the-modified-maquet-technique
#12
Paul Pillard, Veronique Livet, Quentin Cabon, Camille Bismuth, Juliette Sonet, Denise Remy, Didier Fau, Claude Carozzo, Eric Viguier, Thibaut Cachon
OBJECTIVE To evaluate the validity of 2 radiographic methods for measurement of the tibial tuberosity advancement distance required to achieve a reduction in patellar tendon-tibial plateau angle (PTA) to the ideal 90° in dogs by use of the modified Maquet technique (MMT). SAMPLE 24 stifle joints harvested from 12 canine cadavers. PROCEDURES Radiographs of stifle joints placed at 135° in the true lateral position were used to measure the required tibial tuberosity advancement distance with the conventional (A(M)) and correction (A(E)) methods...
December 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27901322/risk-factors-analysis-of-thromboembolectomy-for-acute-thromboembolic-lower-extremity-ischemia-in-native-arteries
#13
Gabriele Piffaretti, Alessandro Angrisano, Marco Franchin, Massimo Ferrario, Nicola Rivolta, Alessandro Bacuzzi, Patrizio Castelli, Matteo Tozzi
BACKGROUND: Aim of this study is to report the results of thromboembolectomy (ThEmb) for acute thromboembolic lower limb ischemia (ATLI) in native arteries and to create a predictive score for amputation-free survival (AFS) at 30 days. METHODS: It is a single center, retrospective analysis of a four years period. All patients had ThEmb: adjunctive procedures included femoral and/or popliteal endarterectomy in 30 (18.3%) cases, PTA- stent in 24 (14.6%), and femoral endarterectomy plus PTA-stent in 12 (7...
November 30, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27896226/use-of-the-directional-atherectomy-for-the-treatment-of-femoro-popliteal-lesions-in-patients-with-critical-lower-limb-ischemia
#14
Umberto Marcello Bracale, Gaetano Vitale, Guido Bajardi, Donatella Narese, Ettore Dinoto, Anna Maria Giribono, Doriana Ferrara, Luca Del Guercio, Massimo Midiri, Felice Pecoraro
: Femoro-popliteal PTA for the treatment of critical limb ischemia is frequently associated with unsatisfactory procedural success rates while directional atherectomy (DCA) has improved success rate since claudicant patients undergoing percutaneous treatment of femoro-popliteal obstructive disease. The aim of this prospective study is to evaluate the safety, efficacy and procedural success of DCA, at one year, in the percutaneous treatment of femoro-popliteal obstructive disease in patients with critical limb ischemia...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27895356/the-power-peripherally-inserted-central-catheter-is-superior-to-a-central-venous-catheter-in-management-of-patients-with-esophageal-variceal-bleeding-undergoing-devascularization
#15
Wen Jing, He Rong, Jiang Li, Zhang Hai Xia, Zhang Hong Yu, Zhang Ke
Peripherally-inserted central catheters (PICC) have a greater retention time and less complications compared to central venous catheters (CVC). The study was conducted from From January of 2014 to December 2015 at Beijing DiTan Hospital, Beijing, China, and comprised 70 patients undergoing devascularisation. Of the total, 36(51.4%) patients underwent placement of PICC (Group A), while 34(48.6%) underwent had CVC (Group B). Venous catheterisation was successful in all patients. The median duration of venous catheterization in Group A was greater than that in Group B (p=0...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27884360/cost-effectiveness-of-endovascular-femoropopliteal-intervention-using-drug-coated-balloons%C3%A2-versus-standard-percutaneous-transluminal-angioplasty-results-from-the-in-pact%C3%A2-sfa-ii-trial
#16
Adam C Salisbury, Haiyan Li, Katherine R Vilain, Michael R Jaff, Peter A Schneider, John R Laird, David J Cohen
OBJECTIVES: The aim of this study was to evaluate the cost-effectiveness of drug-coated balloon (DCB) angioplasty versus standard percutaneous transluminal angioplasty (PTA). BACKGROUND: Recent trials have reported lower rates of target lesion revascularization with DCB angioplasty versus standard PTA. However, the cost-effectiveness of DCB angioplasty is unknown. METHODS: A prospective economic study was performed alongside the IN.PACT SFA II (IN...
November 28, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27869974/-evaluating-productivity-targets-achievement-in-dental-specialty-centers-from-maranh%C3%A3-o-state-brazil-2011
#17
Erika Bárbara Abreu Fonseca Thomaz, Grazianne Medeiros Carvalho de Sousa, Rejane Christine de Sousa Queiroz, Liberata Campos Coimbra
OBJECTIVE: to evaluate productivity targets achievement (PTA) in Dental Specialty Centers (DSCs) from Maranhão State, Brazil. METHODS: this was an ecologic study using secondary data; an indicator for PTA was created for each subgroup of procedures. RESULTS: 25 DSCs were evaluated; the PTA was higher for basic procedures (n=19), followed by endodontics (n=11), oral surgery (n=9) and periodontics (n=8); the best results were obtained at DSCs type II; higher PTA was associated with financial anticipation (basic procedures) and higher Human Development Index, life expectancy and social exclusion rate (endodontics); lower PTA was associated with larger population (endodontics/oral surgery), adherence to the Pact for Health (periodontics/endodontics), larger number of specialties (periodontics) and bigger DSC (oral surgery)...
October 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27868122/fine-tuning-through-valence-bond-tautomerization-of-ancillary-ligands-in-ruthenium-ii-arene-complexes-for-better-anticancer-activity-and-enzyme-inhibition-properties
#18
Poulami Mandal, Novina Malviya, M Fátima C Guedes da Silva, Sandeep Singh Dhankhar, C M Nagaraja, Shaikh M Mobin, Suman Mukhopadhyay
Four new ruthenium arene PTA type complexes have been synthesized using substituted picolinamide derivatives as ancillary ligands and characterized by spectroscopic methods. In one of the complexes, the ancillary ligand has shown an unprecedented valence-bond tautomerization in the presence of an ammonium salt to act as a polar neutral donor ligand making the ligand more prone towards substitution. The same compound has shown remarkable antiproliferative activity against three cancer cell lines with GI50 values comparable to Adriamycin, a known therapeutic drug...
November 21, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27865904/surprises-of-electron-microscopic-imaging-of-proteins-and-polymers-covering-gold-nanoparticles-layer-by-layer
#19
Inna A Pyshnaya, Kristina V Razum, Anton S Dolodoev, Valeriya V Shashkova, Elena I Ryabchikova
Gold nanoparticles (GNPs) are used in complicated nanoconstructions, and their preparation implies careful analysis of the intermediate and resulting products, including visualisation of the NPs. Visualisation of protein and/or organic polymer covers on GNPs using electron microscopy (EM) was a goal of this study. We covered GNPs with human serum albumin or PEG, and then added a second layer of branched or linear polyethyleneimine. EM studies were supplemented with dynamic light scattering, spectrophotometry and gel electrophoresis, which confirmed the presence and integrity of a cover on GNPs in mixtures with uranylacetate (UA) or phosphotungstic acid (PTA)...
November 5, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27861389/characteristics-of-hearing-loss-in-patients-with-herpes-zoster-oticus
#20
Chang-Hee Kim, Hyerang Choi, Jung Eun Shin
Patients with herpes zoster oticus (HZO) may commonly show symptoms associated with 7th and 8th cranial nerve (CN VII and CN VIII) dysfunction. The aim of this study is to investigate the characteristics of hearing loss in patients with HZO and discuss possible mechanisms.Ninety-five HZO patients who showed at least one of the symptoms of CN VII and CN VIII dysfunction between January 2007 and October 2014 were included in this study. Hearing loss was defined when the mean thresholds of pure tone audiometry (PTA) in speech frequency (0...
November 2016: Medicine (Baltimore)
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