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Leonardo Renieri, Caterina Michelozzi, Waleed Brinjikji, Jean Darcout, Adrien Guenego, Ivan Vukasinovic, Philippe Tall, Fabrice Bonneville, Anne-Christine Januel, Christophe Cognard
BACKGROUND AND PURPOSE: Type I and IIa dural arteriovenous fistulas (DAVFs) have a low hemorrhagic risk, but are often the cause of debilitating tinnitus that requires treatment. While Onyx® and PHIL™ (Precipitating hydrophobic injectable liquid) transarterial embolization represent the first endovascular option, there are occasional cases where performing angioplasty and stenting of the affected sinus may lead to satisfactory results. MATERIAL AND METHODS: We retrospectively analyzed four consecutive cases of patients with DAVF-induced pulsatile tinnitus secondary to type I and II DAVFs who were treated with angioplasty and stenting of the sinus only...
December 14, 2017: Clinical Neuroradiology
Mohammad-Hadi S Modaghegh, Shahab Hafezi
PURPOSE: When critical limb ischemia (CLI) occurs in patients with thromboangiitis obliterans (TAO) or Buerger's disease, smoking cessation alone may be insufficient to relieve rest pain and promote wound healing. Accordingly, adjunctive measures are warranted to restore adequate blood flow required for limb salvage. This study aimed to evaluate the feasibility and efficacy of percutaneous transluminal angioplasty (PTA) for the treatment of patients with TAO and CLI. In addition, a review of the literature on endovascular management of TAO is included...
January 1, 2017: Vascular and Endovascular Surgery
Joseph R Scalea, Lauren Pettinato, Blythe Fiscella, Amanda Bartosic, Allison Piedmonte, Jastine Paran, Niket Todi, Eric J Siskind, Stephen T Bartlett
BACKGROUND: The benefits of pancreas transplantation are often difficult to measure. Here, we sought to determine the difference in quality of life for diabetic patients with and without a functional pancreas transplant alone (PTA). METHODS: PTA cases from 1993-2015 were considered. An IRB-approved survey inclusive of 15 questions spanning 4 domains was employed. Chi-square, Fischer's exact, and the T-test were used where appropriate. RESULTS: 137 PTAs were performed during the study period...
December 11, 2017: Clinical Transplantation
Balaji Balagurunathan, Lily Tan, Hua Zhao
For the sustainable production of acetaldehyde, a key raw-material for a large number of chemical products, microbial production is a promising alternative. We have engineered an Escherichia coli strain for acetaldehyde production from glucose by introducing the pyruvate decarboxylase (Pdc) from Zymomonas mobilis and NADH oxidase (Nox) from Lactococcus lactis. Acetaldehyde production was systematically improved by knocking out the competing metabolic pathways. Multiple knockout strains were created and a final acetaldehyde titre of 0...
February 2018: Enzyme and Microbial Technology
Giuseppe Gallo, Andrea Scaloni
Proteomics based on 2D-Difference In Gel Electrophoresis (2D-DIGE) coupled with mass spectrometry (MS) procedures can be considered a "gold standard" to determine quantitatively and comparatively protein abundances in cell extracts from different biological sources/conditions according to a gel-based approach. In particular, 2D-DIGE is used for protein specie separation, detection, and relative quantification, whenever tandem MS is used to obtain peptide sequence information that is managed according to bioinformatic procedures to identify the differentially represented protein species...
2018: Methods in Molecular Biology
Haoran Guo, Enmin Ding, Ying Bai, Hengdong Zhang, Huanxi Shen, Jun Wang, Xianping Song, Wenyan Cai, Jiadi Guo, Baoli Zhu
Noise induced hearing loss (NIHL), a multifactorial disease involving both genetic and environmental factors, is one of the most important occupational health hazards. Nonetheless, the influence of FOXO3 variants on NIHL risk have not been illuminated. This research was conducted to explore the effects of FOXO3 polymorphisms on individual susceptibility to NIHL. A total of 2689 industrial workers from one textile factory of east China were recruited to participate in the current research. Venous blood was collected, questionnaire and pure-tone audiometry (PTA) was conducted by specialist physicians...
2017: PloS One
Elena Lalinde, M Teresa Moreno, Rebeca Lara, Icíar P López, Elvira Alfaro-Arnedo, José G Pichel, Sergio Piñeiro-Hermida
Complexes based on 2-(4-substituted)benzothiazole ligands of type [Pt(R-pbt-C,N)Cl(L)] (R = Br 1, Me2N 2; L = DMSO a, PTA b, TPPTS c) and [Pt(Br-pbt-C)Cl(PTA)2] 3 are presented. On the basis of the photophysical data and TD-DFT calculations (1a, 2a) the low lying transitions (absorption and emission) were associated to ligand center (LC) with minor MLCT character and to intraligand ILCT charge transfer [Me2N-pbtpbt] excited states, respectively. The study of the effect of the concentration on emissive behavior of 2a,b indicated the occurrence of aggregation induced luminescence properties (Pt···Pt/·· interactions)...
December 8, 2017: Chemistry: a European Journal
Nadia Parmhans, Szilard Sajgo, Jingwen Niu, Wenqin Luo, Tudor Constantin Badea
We report the retinal expression pattern of Ret, a receptor tyrosine kinase for the Glial Derived Neurotrophic Factor (GDNF) family ligands (GFLs), during development and in the adult mouse. Ret is initially expressed in Retinal Ganglion Cells (RGCs), followed by Horizontal Cells (HCs) and Amacrine Cells (ACs), beginning with the early stages of postmitotic development. Ret expression persists in all three classes of neurons in the adult. Using RNA sequencing, immunostaining and random sparse recombination, we show that Ret is expressed in at least three distinct types of ACs, and ten types of RGCs...
December 8, 2017: Journal of Comparative Neurology
Shinya Morita, Yuji Nakamaru, Atsushi Fukuda, Keishi Fujiwara, Kimiko Hoshino, Akihiro Homma
OBJECTIVE: We aimed to evaluate the clinical features and treatment outcomes for patients with idiopathic and secondary external auditory canal cholesteatoma (EACC), and to validate the treatment strategy from the perspective of hearing as well as etiology and staging. STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral center and affiliated hospitals. PATIENTS: Fifty-eight patients with idiopathic EACC and 14 patients with secondary EACC...
November 28, 2017: Otology & Neurotology
M Krings, H Müller, M J Heneka, D Rödder
Micro-computed tomography (micro-CT) scanning and three-dimensional reconstruction have revolutionized morphological studies. Whereas species descriptions and comparative studies formerly were based on external appearance and dissection, we now can visualize muscles, skeleton and viscera in intact animals. In most cases, visualization of internal structures depends on appropriate staining methods. Staining with iodine, phosphotungstic acid (PTA) and osmium tetroxide are established methods, but some problems remain...
December 6, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Farid Alzhrani, Rayan Alhussini, Rawan Hudeib, Tuqa Alkaff, Tahera Islam, Abdulrahman Alsanosi
OBJECTIVE: To assess the outcome and efficacy of cochlear implantation in children with genetic syndromes. METHOD: Study design: case-control study. SETTING: A cochlear implantation tertiary referral center. PATIENTS: All pediatric cochlear implantation recipients with Waardenburg syndrome, Usher syndrome, Dandy-Walker syndrome, or albinism. A control group was appropriately matched to the syndromic group with regard to age at implantation and duration of device use...
December 4, 2017: European Archives of Oto-rhino-laryngology
Jessica Trevena-Peters, Jennie Ponsford, Adam McKay
BACKGROUND: Patients in posttraumatic amnesia (PTA) may receive limited rehabilitation due to the risk of overstimulation and agitation. This assumption has not been tested. OBJECTIVE: To examine the relationship between agitated behavior and participation in therapy for retraining of activities of daily living (ADL) while in PTA. SETTING: Inpatient rehabilitation center. PARTICIPANTS: A total of 104 participants with severe traumatic brain injury, admitted to rehabilitation, in PTA of more than 7 days...
November 29, 2017: Journal of Head Trauma Rehabilitation
Justin S Golub, Frank R Lin, Lawrence R Lustig, Anil K Lalwani
OBJECTIVE: The prevalence of unilateral hearing loss (UHL) in adults has not been well characterized. The objectives of this study are to determine the prevalence of UHL in U.S. adults and its treatment with hearing aids using a nationally representative study. STUDY DESIGN: Cross-sectional national epidemiologic study (n = 6,242). METHODS: Subjects ≥ 18 years old with audiometric testing in the 2005 to 2006, 2009 to 2010, and 2011 to 2012 cycles of the National Health and Nutrition Examination Study were included...
November 29, 2017: Laryngoscope
Laurence Ag Marshman, Maria Hennessy, Lorryn Delle Baite, Grace Britton
BACKGROUND: Post-traumatic amnesia (PTA) after traumatic brain injury (TBI) comprises anterograde amnesia (AA), disorientation and retrograde amnesia (RA). However, RA is often neither assessed nor emphasized. A recent study demonstrated that, whilst AA and disorientation were both present in non-TBI in-patients uniformly taking opioids, RA was absent. This suggests potentially significant utility with RA-assessment alone, since opioids are commonly prescribed post-TBI. METHODS: We compared RA-recovery with AA-recovery in a prospective cohort post-TBI...
November 27, 2017: World Neurosurgery
Christoph Spiekermann, Antonella Russo, Markus Stenner, Claudia Rudack, Johannes Roth, Thomas Vogl
Peritonsillar abscess (PTA) is a very frequent reason for urgent outpatient consultation and otolaryngological hospital admission. Early, correct diagnosis and therapy of peritonsillar abscess are important to prevent possible life-threatening complications. Based on physical examinations, a reliable differentiation between peritonsillar cellulitis and peritonsillar abscess is restricted. A heterodimeric complex called calprotectin consists of the S100 proteins A8 and A9 (S100A8/A9) and is predominantly expressed not only in monocytes and neutrophils but also in epithelial cells...
2017: Disease Markers
Zuoyong Zhou, Mengsi Zhang, Hexian Li, Haoyue Yang, Xiaoxia Li, Xinyue Song, Zhiying Wang
BACKGROUND: Staphylococcus aureus is an important zoonotic pathogen which not only causes significant economic loss in livestock production but also poses a potential threat to public health. Compared with bovine and swine, the information on the colonization of S. aureus in goats is very limited. To understand the prevalence and characteristics of S. aureus in goats, we used the nasal swabs collected from apparently healthy goats to isolate S. aureus, and tested their antimicrobial susceptibility, virulence gene carrying levels, and multilocus sequence typing (MLST)...
November 25, 2017: BMC Veterinary Research
Diego N Alza Salvatierra, Philip G Witte, Harry W Scott, Clare Catchpole
Case series summary Pantarsal arthrodesis (PTA) was performed in seven tarsi of six cats, using orthogonal (dorsal and medial) veterinary cuttable plates (VCPs) without postoperative external coaptation. Short-term outcomes, arthrodesis progression and complications were assessed using a retrospective review of case notes (veterinary examination) and radiographs. Long-term outcomes were assessed via owner questionnaire (Feline Musculoskeletal Pain Index [FMPI]). Mean angle of PTA was 136° (range 116-166°)...
March 1, 2017: Journal of Feline Medicine and Surgery
Seo-Young An, Chang-Hyeon An, Kyu-Yup Lee, Jeong Hun Jang, Yun-Hoon Choung, Sang Heun Lee
OBJECTIVE: To assess the usefulness of cone beam computed tomography (CBCT) for characterizing electrode insertion and evaluate the influence of electrode insertion status on post-cochlear implantation (CI) outcomes. DESIGN: Twenty-six ears with post-CI CBCT scans were included. The devices were MED-EL Flex28 (n = 21) and Nucleus slim straight (n = 5). The parameters including cochlear duct length (CDL), insertion depth angle (IDA), insertion length of electrode (IL), and cochlear coverage (CC) were analyzed and compared with aided pure-tone threshold (PTA) with implant in free field, and open-set sentence score...
November 26, 2017: Acta Oto-laryngologica
Isa Kaya, Goksel Turhal, Arin Ozturk, Sercan Gode, Cem Bilgen, Tayfun Kirazli
Objectives: The aim of this prospective clinical study was to measure the audiologic outcomes of the patients that underwent endoscopic transcanal cartilage tympanoplasty, and to investigate the effects on cochlear function. Methods: Thirty-three patients (33 ears) who were diagnosed with noncomplicated chronic otitis media and underwent endoscopic transcanal cartilage tympanoplasty technique were included. Pre- and postoperative first month distortion product otoacoustic emission (DPOAE) signal-to-noise ratio (SNR), bone conduction hearing levels and air bone gap (ABG) values were measured and total endoscope usage time was noted...
November 28, 2017: Clinical and Experimental Otorhinolaryngology
Kelly R Sheerin, Thor F Besier, Duncan Reid, Patria A Hume
Tibial acceleration is a surrogate measure for impact loading and lower limb fatigue injury in runners. Triaxial accelerometers may offer reliable and practical measurement of resultant peak tibial acceleration (PTA). With such potential in mind, this study examined variability and measurement reliability of tibial acceleration in 14 runners at baseline at one week, and eight of the runners again at six months. Triaxial accelerometers were attached to the distal tibiae of runners before they ran on a treadmill for two minutes each, at speeds of 2...
November 24, 2017: Sports Biomechanics
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