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https://www.readbyqxmd.com/read/29054899/lung-adenocarcinoma-metastastic-lesion-in-the-internal-auditory-meatus
#1
Eugene Hung Chih Wong, Daniel Bodmer, Nora Tetter, Yves Brand
Metastasis to the cerebellopontine angle (CPA) or internal auditory meatus (IAM) is rare.We report a rare case of a 69-year-old woman with metastatic lung adenocarcinoma, who presented with 2 weeks history of left-sided hearing loss and progressively worsening vertigo. Examination revealed a left-sided facial nerve palsy while pure tone audiometry (PTA) showed a new left-sided deafness. MRI showed a new enhancing soft tissue lesion in the left IAM, highly suspicious of new metastases from her progressive lung cancer, which contributed to her neuro-otological symptoms...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29053264/cytotoxic-half-sandwich-rh-iii-and-ir-iii-%C3%AE-diketonates
#2
Agnese Petrini, Riccardo Pettinari, Fabio Marchetti, Claudio Pettinari, Bruno Therrien, Agustı N Galindo, Rosario Scopelliti, Tina Riedel, Paul J Dyson
A series of half-sandwich pentamethylcyclopentadienyl rhodium(III) and iridium(III) complexes [Cp*M(DBM/HDB/AVB)Cl] and [Cp*M(DBM/HDB/AVB)(PTA)][SO3CF3], where Cp* = pentamethylcyclopentadienyl, the proligands DBMH = dibenzoylmethane, HDBH = o-hydroxydibenzoylmethane, AVBH = avobenzone, and PTA = 1,3,5-triaza-7-phosphaadamantane, is reported. All the complexes were characterized by IR, (1)H and (13)C NMR spectroscopy, electrospray ionization mass spectrometry, elemental analysis, and DFT calculations. Five of the complexes have also been characterized in the solid-state by X-ray crystallography...
October 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29050215/proteomics-analysis-of-bladder-cancer-invasion-targeting-eif3d-for-therapeutic-intervention
#3
Agnieszka Latosinska, Marika Mokou, Manousos Makridakis, William Mullen, Jerome Zoidakis, Vasiliki Lygirou, Maria Frantzi, Ioannis Katafigiotis, Konstantinos Stravodimos, Marie C Hupe, Maciej Dobrzynski, Walter Kolch, Axel S Merseburger, Harald Mischak, Maria G Roubelakis, Antonia Vlahou
Patients with advanced bladder cancer have poor outcomes, indicating a need for more efficient therapeutic approaches. This study characterizes proteomic changes underlying bladder cancer invasion aiming for the better understanding of disease pathophysiology and identification of drug targets. High resolution liquid chromatography coupled to tandem mass spectrometry analysis of tissue specimens from patients with non-muscle invasive (NMIBC, stage pTa) and muscle invasive bladder cancer (MIBC, stages pT2+) was conducted...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049627/international-outcome-inventory-for-hearing-aids-data-from-a-large-swedish-quality-register-database
#4
Stig Arlinger, Peter Nordqvist, Marie Öberg
Purpose: The purpose of this study was to analyze a database of completed International Outcome Inventory for Hearing Aids (IOI-HA) questionnaires obtained from over 100,000 clients fitted with new hearing aids in Sweden during the period of 2012-2016. Mean IOI-HA total scores were correlated with degree of hearing loss, unilateral versus bilateral fitting, first-time versus return clients, gender, and variation among dispensing clinics. The correlations with expectations, service quality, and technical functioning of the hearing aids were also analyzed...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29048485/isavuconazole-susceptibility-of-clinical-aspergillus-fumigatus-isolates-and-feasibility-of-isavuconazole-dose-escalation-to-treat-isolates-with-elevated-mics
#5
Jochem B Buil, Roger J M Brüggemann, Roeland E Wasmann, Jan Zoll, Jacques F Meis, Willem J G Melchers, Johan W Mouton, Paul E Verweij
Introduction: Isavuconazole is a new triazole approved for the treatment of invasive aspergillosis. We investigated isavuconazole MIC distributions, isavuconazole MIC correlations with those of other azoles and pharmacodynamics of isavuconazole in low-level resistant Aspergillus fumigatus isolates. Methods: Isavuconazole, voriconazole, itraconazole and posaconazole susceptibility of 487 clinical A. fumigatus isolates was determined by EUCAST broth microdilution methodology...
October 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29045970/-unilateral-patellar-resurfacing-in-bilateral-total-knee-arthroplasty-a-randomized-controlled-study
#6
J F Wang, Z Li, K S Zhang, F Yuan, R J Li, Q J Zhong, Z P Guan
OBJECTIVE: To perform unilateral patellar resurfacing and contralateral patellar retention in bilateral total knee arthroplasty (TKA) randomly, and to compare the clinical effects of patellar retention with patellar resurfacing in TKA. METHODS: In the study, 14 bilateral knee osteoarthritis (OA) patients were randomized in the bilateral TKA to receive unilateral patellar resurfacing and contralateral patellar retention, including 28 knees, all were females, 53 to 78 years old, with average (66...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29043112/tumor-infiltrating-cd8-lymphocytes-predict-different-clinical-outcomes-in-organ-and-non-organ-confined-urothelial-carcinoma-of-the-bladder-following-radical-cystectomy
#7
Shiqiang Zhang, Jun Wang, Xinyu Zhang, Fangjian Zhou
Tumor-infiltrating lymphocytes (TILs) are associated with better clinical outcomes in many tumors. TILs represent a cell-mediated immune response against the carcinoma. CD8+ TILs are a crucial component of cell-mediated immunity. The significance of CD8+ TILs has not been reported respectively in organ- and non-organ-confined urothelial carcinoma (UC) of the bladder. We explored the prognostic value of CD8+ TILs in the two groups. The presence of CD8+ TILs was assessed by immunohistochemical staining of whole tissue sections from 75 organ and 51 non-organ-confined disease patients with long-term follow-up, and its correlation with clinicopathological features and overall survival (OS) was determined...
2017: PeerJ
https://www.readbyqxmd.com/read/29037861/biologic-behavior-and-long-term-outcomes-of-carcinoma-in-situ-in-upper-urinary-tract-managed-by-radical-nephroureterectomy
#8
Teruo Inamoto, Hideyasu Matsuyama, Naokazu Ibuki, Kazumasa Komura, Kiyoshi Takahara, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Nagao, Makito Miyake, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma
BACKGROUND AND OBJECTIVES: Carcinoma in situ (CIS) in urothelial carcinoma generally has poor prognosis, but the outcomes of pure/primary CIS tumor (p-CIS) and the behavior of concomitant CIS (c-CIS) with pTa-pT4 upper tract urothelial carcinoma (UTUC) managed by nephroureterectomy has not been specified. The aim of our study was to explore the biological and prognostic features of c-CIS, compared with p-CIS. PATIENTS AND METHODS: We queried multicenter UTUC database...
October 13, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29037345/factors-influencing-the-hemodynamic-response-to-balloon-angioplasty-in-the-treatment-of-outflow-anomalies-of-internal-jugular-veins
#9
Alessia Giaquinta, Clive B Beggs, Massimiliano Veroux, Ester De Marco, Adalberto Sanzone, Carla Virgilio, Pierfrancesco Veroux
OBJECTIVE: Percutaneous transluminal angioplasty (PTA) of the internal jugular veins (IJVs) has been proposed in recent years to treat chronic cerebrovascular venous insufficiency, with discordant results. Moreover, very little is known about the efficacy of PTA in restoring a normal cerebral venous outflow. The aim of this study was to investigate the anatomic factors and patient characteristics that might influence the efficacy of PTA of the IJV. METHODS: There were 797 consecutive patients with venous outflow anomalies who underwent standardized, operator-independent catheter venography and PTA of the IJVs...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29032420/cochlear-implantation-with-the-nucleus-slim-modiolar-electrode-ci532-a-preliminary-experience
#10
Domenico Cuda, Alessandra Murri
To combine the benefits of perimodiolar stimulation with minimal insertion trauma, a thin, pre-curved electrode (CI532) was recently developed by Cochlear Ltd. (Sidney). This array is held straight prior to insertion by an external polymer reloadable sheath that is removed after full electrode insertion. Sixty-seven patients suffering from severe-to-profound sensorineural hearing loss (mean age 42.2 years; mean duration of the hearing loss 19.6 years; mean PTA thresholds at 250-2000 Hz 92.4 dB HL) were implanted with the CI532...
October 14, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29031986/endovascular-interventions-for-femoropopliteal-peripheral-artery-disease-a-network-meta-analysis-of-current-technologies
#11
REVIEW
Michael R Jaff, Teresa Nelson, Nicole Ferko, Melissa Martinson, Louise H Anderson, Sarah Hollmann
PURPOSE: To use network meta-analysis (NMA) to determine the optimal endovascular strategy for management of femoropopliteal peripheral artery disease (PAD) given the lack of multiple prospective randomized trials to guide treatment decisions. MATERIALS AND METHODS: NMA is a new meta-analytic method that permits comparisons among any 2 therapies by combining results of a collection of clinical trials conducted in the same or similar patient population. NMA was used to analyze data from 15 randomized controlled trials (RCTs) and 10 prospective, multicenter, single-arm trials (combined evidence [CE] NMA) that evaluated target lesion revascularization (TLR) for 5 endovascular strategies: bare metal stent (BMS), polymer-covered metal stent (CMS), drug-eluting stent (DES), drug-coated balloon (DCB) and percutaneous transluminal angioplasty (PTA)...
October 12, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29022079/co2-laser-stapedotomy-safety-influence-of-laser-energy-and-time-on-bone-conduction-hearing-levels
#12
Uwe Schönfeld, Hu Weiming, Veit M Hofmann, Sergije Jovanovic, Andreas E Albers
Total laser energy in CO2 stapedotomy depends on the laser settings and the amount of applications. It is unclear if the amount of total laser energy affects bone-conduction hearing thresholds and if possible effects are temporary or permanent. Alterations of bone-conduction hearing thresholds after single or multiple-shot CO2 laser stapedotomy were analyzed between 1 and 3 weeks and 1.5-6 months after primary (n = 501) or revision surgeries (n = 153) and correlated to time, laser energy, frequency, surgical technique, and pathology encountered in revision stapedotomy...
October 11, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28994833/the-efficacy-and-safety-of-endovascular-recanalization-of-occluded-large-cerebral-arteries-during-the-subacute-phase-of-cerebral-infarction-a-case-series-report
#13
Kangning Chen, Xianhua Hou, Zhenhua Zhou, Guangjian Li, Qu Liu, Li Gui, Jun Hu, Shugui Shi
BACKGROUND: Intravenous tissue plasminogen activator with or without mechanical thrombectomy during the acute phase are approved therapies for ischaemic stroke. Due to the short treatment time window (<6 hours) and often treatment failure, these patients would still have an intracranial arterial occlusion (IAO). It is unclear whether these patients can benefit from subsequent interventional recanalizationof their occluded artery in the subacute phase. In this retrospective study, we have examined the efficacy and safety in patients who have received either percutaneous transluminal angioplasty (PTA) or percutaneous transluminal angioplasty and stenting (PTAS) for IAO in the subacute phase of their stroke...
September 2017: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28991528/protosappanin-a-exerts-anti-neuroinflammatory-effect-by-inhibiting-jak2-stat3-pathway-in-lipopolysaccharide-induced-bv2-microglia
#14
Li-Chao Wang, Li-Xi Liao, Ming-Bo Zhao, Xin Dong, Ke-Wu Zeng, Peng-Fei Tu
Microglial activation and resultant neuroinflammatory response are implicated in various brain diseases including Alzheimer's disease and Parkinson's disease. Treatment with anti-neuroinflammatory agents could provide therapeutic benefits for such disorders. Protosappanin A (PTA) is a major bioactive ingredient isolated from Caesalpinia sappan L.. In this work, the anti-neuroinflammatory effects of PTA on LPS-stimulated BV2 cells were investigated and the underlying mechanisms were explored. Results showed that PTA significantly inhibited the production of TNF-α and IL-1β in LPS-activated BV2 microglia...
September 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28990660/relationship-of-stroke-risk-and-hearing-loss-in-african-americans-the-jackson-heart-study
#15
Jonathan E Sorrel, Charles E Bishop, Christopher Spankovich, Dan Su, Karen Valle, Samantha Seals, John M Schweinfurth
OBJECTIVES/HYPOTHESIS: To evaluate the relationships among measures of stroke risk and hearing in an African American cardiovascular study cohort. STUDY DESIGN: Prospective cohort study. METHODS: The relationships between stroke risk profiles and hearing of 1,107 individuals from a cohort of African Americans were assessed. Several different hearing pure-tone averages (PTAs) were constructed representing different frequency regions of hearing, namely PTA low, PTA mid, and PTA high...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28988293/persistent-trigeminal-artery-variant-terminating-in-the-posterior-inferior-cerebellar-artery-a-case-report
#16
Ga Young Lee, Young Jin Heo, Hyun Seok Jung, Hye Jung Choo, Young Jun Cho, Hae Woong Jeong, Jin Wook Baek
Persistent trigeminal artery (PTA) is a rare cerebrovascular variation of remnant fetal carotid-vertebrobasilar anastomoses. The PTA variant terminates in the cerebellar artery with no direct connection to the basilar artery. We present a rare case of a PTA variant that terminated directly into the ipsilateral posterior inferior cerebellar artery.
October 7, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28984807/decline-of-low-frequency-hearing-in-people-with-ski-slope-hearing-loss-implications-for-electrode-array-insertion
#17
Jasper Schuurbiers, Gertjan Dingemanse, Mick Metselaar
HYPOTHESIS: The decline of low-frequency hearing in people with ski-slope hearing loss varies and might depend on etiology. BACKGROUND: People with ski-sloping hearing loss might benefit from cochlear implantation with preservation of residual hearing. To reduce the risk of losing low-frequency hearing after implantation, the electrode-array can be inserted partially up to the desired frequency. That, however, obstructs electrical stimulation of lower frequencies...
October 4, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28979096/ectasia-following-small-incision-lenticule-extraction-smile-a-review-of-the-literature
#18
REVIEW
Majid Moshirfar, Julio C Albarracin, Jordan D Desautels, Orry C Birdsong, Steven H Linn, Phillip C Hoopes
PURPOSE: Four cases of corneal ectasia after small-incision lenticule extraction (SMILE) have been reported. In this review, we provide an overview of the published literature on corneal ectasia after SMILE and risk factors associated with this complication. METHODS: Case reports were identified by a search of seven electronic databases for pertinent heading terms between 2011 and July 2017. We identified patient characteristics and surgical details including preoperative topography, central corneal thickness, and anterior keratometry (Km)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28977970/cd147-as-a-novel-biomarker-for-predicting-the-prognosis-and-clinicopathological-features-of-bladder-cancer-a-meta-analysis
#19
Hongru Li, Yadong Xu, Hui Li
OBJECTIVE: To assess the prognostic and clinicopathological characteristics of CD147 in human bladder cancer. METHODS: Studies on CD147 expression in bladder cancer were retrieved from PubMed, EMBASE, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, and the WanFang databases. Outcomes were pooled with meta-analyzing softwares RevMan 5.3 and STATA 14.0. RESULTS: Twenty-four studies with 25 datasets demonstrated that CD147 expression was higher in bladder cancer than in non-cancer tissues (OR=43...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28971861/pharmacokinetic-properties-of-micafungin-in-critically-ill-patients-diagnosed-with-invasive-candidiasis
#20
J M Boonstra, K C van der Elst, A Veringa, E M Jongedijk, R J Brüggemann, R A Koster, G A Kampinga, J G Kosterink, T S van der Werf, J G Zijlstra, D J Touw, J W C Alffenaar
Background: The estimated attributable mortality rate for invasive candidiasis (IC) in the Intensive Care Unit (ICU) setting varies from 30-40%. Physiological changes in critically ill patients may affect the distribution and elimination of micafungin and therefore dosing adjustments might be mandatory. Objective: To determine the pharmacokinetic parameters of micafungin in critically ill patients and assess the probability of target attainment (PTA). Methods: Micafungin plasma concentrations were measured to estimate the pharmacokinetic properties of micafungin...
October 2, 2017: Antimicrobial Agents and Chemotherapy
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