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Carlos J Leitão, Juan Rafael Lima-Rodríguez, Fatima Ferreira, Catarina Avelino, Francisco M Sánchez-Margallo, Luís Antunes
BACKGROUND: Evaluation of nociceptive-antinociceptive balance during general anesthesia is still challenging and routinely based on clinical criteria. Analgesic drug delivered may be optimized with parasympathetic tone activity (PTA) monitor. This study compares ketorolac and ketorolac/tramadol balance analgesia using a PTA monitor. METHODS: Pain intensity response was assessed using a 0-100 numerical state scale (PTA) after nociceptive stimuli in pigs under stable sevoflurane anesthesia...
June 14, 2018: Anesthesia and Analgesia
Talal M Al-Qaoud, Jon S Odorico, Robert R Redfield
PURPOSE OF REVIEW: Pancreas transplantation in type 2 diabetes mellitus (T2DM) candidates remains disproportionately lower than in type 1 diabetes mellitus (T1DM); however, outcomes in carefully selected patients mirrors that of T1DM. Despite the 2014 United Network for Organ Sharing (UNOS) eligibility criteria for simultaneous pancreas/kidney transplant (SPK) transplantation in T2DM patients, an expected increase in the number of transplants was not observed. RECENT FINDINGS: In an updated International Pancreas and Transplant Registry (IPTR) analysis, 1514 primary deceased donor pancreas transplants were performed in T2DM recipients [1995-2015, SPK 88%, pancreas after kidney (PAK) 9%, pancreas transplant alone (PTA) 3%]...
June 18, 2018: Current Opinion in Organ Transplantation
Anne Fournier, Sylvain Goutelle, Yok-Ai Que, Philippe Eggimann, Olivier Pantet, Farshid Sadeghipour, Pierre Voirol, Chantal Csajka
Objectives: To investigate the population pharmacokinetics (PK) of amoxicillin in ICU burn patients and the optimal dosage regimens. METHODS: Prospective study involving 21 consecutive burn patients receiving amoxicillin. PK data were analysed using non-linear mixed effects modelling. Monte-Carlo simulations assessed the influence of various amoxicillin dosage regimens with identified covariates on the probability to achieve a target (PTA) value of time during which free amoxicillin concentrations in plasma exceeded the minimal inhibitory concentration ( f T>MIC)...
June 18, 2018: Antimicrobial Agents and Chemotherapy
Daniel Q Sun, C Blake Sullivan, Raymund W Kung, Megan Asklof, Marlan R Hansen, Bruce J Gantz
OBJECTIVE: To evaluate the association between signal changes during intraoperative audiologic monitoring and postoperative audiometric outcome in patients undergoing vestibular schwannoma (VS) resection via middle cranial fossa (MCF) approach. STUDY DESIGN: Retrospective chart review. SETTING: Academic tertiary referral center. PATIENTS: One hundred twenty-six consecutive patients (mean age 48.6 yrs, range 16-67; mean tumor size 9...
June 15, 2018: Otology & Neurotology
Chulwoo Park, Woojun Park
Many petroleum-polluted areas are considered as extreme environments because of co-occurrence of low and high temperatures, high salt, and acidic and anaerobic conditions. Alkanes, which are major constituents of crude oils, can be degraded under extreme conditions, both aerobically and anaerobically by bacteria and archaea of different phyla. Alkane degraders possess exclusive metabolic pathways and survival strategies, which involve the use of protein and RNA chaperones, compatible solutes, biosurfactants, and exopolysaccharide production for self-protection during harsh environmental conditions such as oxidative and osmotic stress, and ionic nutrient-shortage...
2018: Frontiers in Microbiology
Han Qin, Ling Fu, Bo Hu, Xiang Liao, Jian Lu, Wenjing He, Shanshan Liang, Kuan Zhang, Ruijie Li, Jiwei Yao, Junan Yan, Hao Chen, Hongbo Jia, Benedikt Zott, Arthur Konnerth, Xiaowei Chen
The ability to remember and to navigate to safe places is necessary for survival. Place navigation is known to involve medial entorhinal cortex (MEC)-hippocampal connections. However, learning-dependent changes in neuronal activity in the distinct circuits remain unknown. Here, by using optic fiber photometry in freely behaving mice, we discovered the experience-dependent induction of a persistent-task-associated (PTA) activity. This PTA activity critically depends on learned visual cues and builds up selectively in the MEC layer II-dentate gyrus, but not in the MEC layer III-CA1 pathway, and its optogenetic suppression disrupts navigation to the target location...
June 5, 2018: Neuron
Sol Ahn, Scott L Nauert, Cassandra T Buru, Martino Rimoldi, Hyeju Choi, Neil M Schweitzer, Joseph T Hupp, Omar K Farha, Justin M Notestein
Acid-catalyzed skeletal C-C bond isomerizations are important benchmark reactions for the petrochemical industries. Among those, o-xylene isomerization/disproportionation is a probe reaction for strong Brønsted acid catalysis, and it is also sensitive to the local acid site density and pore topology. Here, we report on the use of phosphotungstic acid (PTA) encapsulated within NU-1000, a Zr-based metal-organic framework (MOF), as a catalyst for o-xylene isomerization at 523 K. Extended X-ray absorption fine structure (EXAFS), 31P NMR, N2 physisorption, and XRD show that the catalyst is structurally stable with time-on-stream, and that WOx clusters are necessary for detectable rates, consistent with conventional catalysts for the reaction...
June 17, 2018: Journal of the American Chemical Society
Benjamin M Woolston, David F Emerson, Devin H Currie, Gregory Stephanopoulos
Clostridium ljungdahlii has emerged as an attractive candidate for the bioconversion of synthesis gas (CO, CO2 , H2 ) to a variety of fuels and chemicals through the Wood-Ljungdahl pathway. However, metabolic engineering and pathway elucidation in this microbe is limited by the lack of genetic tools to downregulate target genes. To overcome this obstacle, here we developed an inducible CRISPR interference (CRISPRi) system for C. ljungdahlii that enables efficient (>94%) transcriptional repression of several target genes, both individually and in tandem...
June 12, 2018: Metabolic Engineering
Bin Zhang, Miao Yu, Wen-Ping Wei, Bang-Ce Ye
BACKGROUND: ʟ-Ornithine is an important amino acid with broad applications in pharmaceutical and food industries. Despite lagging ʟ-ornithine productivity and cost reduction, microbial fermentation is a promising route for sustainable ʟ-ornithine production and thus development of robust microbial strains with high stability and productivity is essential. RESULTS: Previously, we systematically developed a new strain, SO1 originate from Corynebacterium glutamicum S9114, for ʟ-ornithine production...
June 13, 2018: Microbial Cell Factories
Adela Nechifor-Boilă, Myriam Decaussin-Petrucci, Agota Varga-Ilyés, Laura Chinezu, Cosmin Caraşca, Angela Borda
We report three primary thyroid angiosarcoma (PTA) cases revealing distinctive morphological features. A systematic literature review completed our analysis to evaluate the most important morphological factors for predicting prognosis in PTAs. Three rare PTA cases were analysed. In addition, we identified 46 previously reported PTAs with available follow-up data to compare morphological features related to prognosis between patients with a favourable <i><i><i><i>versus</i></i></i></i> aggressive outcome...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Marco Meloni, Valentina Izzo, Laura Giurato, Costantino Del Giudice, Valerio Da Ros, Valerio Cervelli, Roberto Gandini, Luigi Uccioli
Objective: To establish the rate of clinical recurrence of critical limb ischemia (CLI) in diabetic patients with ischemic foot ulcers (DFUs) treated by percutaneous transluminal angioplasty (PTA). Approach: The study group was composed of 304 patients with ischemic DFUs treated by PTA. We evaluated the rate of clinical recurrence of CLI requiring a second PTA (repeated PTA [rePTA]), the factors related to CLI relapse, and the outcomes of rePTA patients. The follow-up was 12.5 ± 6.6 months. Results: Seventy-four of 304 patients (24...
June 1, 2018: Advances in Wound Care
Luca Viganò, Andrea Laurenzi, Luigi Solbiati, Fabio Procopio, Daniel Cherqui, Guido Torzilli
BACKGROUND: Patients with a single hepatocellular carcinoma (HCC) ≤3 cm and preserved liver function have the highest likelihood to be cured if treated. The most adequate treatment methods are yet a matter that is debated. METHODS: We reviewed the literature about open anatomic resection (AR), laparoscopic liver resection (LLR), and percutaneous thermal ablation (PTA). RESULTS: PTA is effective as resection for HCC < 2 cm, when they are neither subcapsular nor perivascular...
June 11, 2018: Digestive Surgery
Daniel Q Sun, Raymond W Kung, Marlan R Hansen, Bruce J Gantz
OBJECTIVE: To determine the association between radiographic cerebrospinal fluid (CSF) cap in the lateral internal auditory canal (IAC) and likelihood of successful hearing preservation in middle cranial fossa (MCF) vestibular schwannoma (VS) surgery. STUDY DESIGN: Retrospective chart review. SETTING: Academic tertiary referral center. PATIENTS: One hundred thirty-eight consecutive patients (mean age/standard deviation, SD, 50/11 yr) who underwent MCF VS resection...
July 2018: Otology & Neurotology
Thomas M Kaffenberger, Nandini Govil, Amber D Shaffer, David H Chi
OBJECTIVE: Ossicular chain reconstruction (OCR) is a surgical method used to repair conductive hearing loss. In children, up to 40% of OCRs will require revisions. In this study, our aims were to validate improvement in hearing outcomes following revision OCR and identify prognostic factors for successful revision OCRs. DESIGN: Retrospective review at the Children's Hospital of Pittsburgh from 2003 to 2014. SETTING: Tertiary referral center...
July 2018: Otology & Neurotology
Joost Josephus Stephanus van Dinther, Renaat Coopman, Jean-Philippe Vercruysse, Thomas Somers, Andrzej Zarowski, Robby Vanspauwen, Youri Maryn, Cornelis Wilhelmus Radboud Jozef Cremers, Frans Erwin Offeciers
OBJECTIVE: To present the hearing results of a 5-year longitudinal study in a pediatric population undergoing surgery for extensive cholesteatoma using a canal wall up (CWU) approach with bony obliteration of the mastoid and epitympanic space, with a standard residual rate of 5.8%, a recurrence rate of 2.9%, and all ears waterproof, free of otorrhea and all external ear canals patent and self-cleaning. STUDY DESIGN: Retrospective consecutive study. PATIENTS: Thirty-three children (≤18 yr) undergoing surgery for cholesteatoma (34 ears) between 1997 and 2009...
July 2018: Otology & Neurotology
Kimbra Kenney, Bao-Xi Qu, Chen Lai, Christina Devoto, Vida Motamedi, William C Walker, Harvey S Levin, Tracy Nolen, Elisabeth A Wilde, Ramon Diaz-Arrastia, Jessica Gill
OBJECTIVE: The objective of the study is to measure plasma and exosomal levels of tau, phosphorylated tau (p-tau), and amyloid beta (Aβ) in Veterans with historical mild traumatic brain injury (mTBI) and chronic neuropsychological symptoms. METHODS: Tau, p-tau, Aβ40, and Aβ42 were measured by ultrasensitive immunoassay in plasma and exosomes from 195 Veterans enrolled in the Chronic Effects of Neurotrauma Consortium Multicenter Observational Study. Protein biomarkers were compared among groups with and without mTBI with loss of consciousness (LOC) or post-traumatic amnesia (PTA), and also in those with and without repetitive (≥3) mTBI (rTBI) compared to those with 0 (TBI-neg) and 1-2 mTBI...
June 11, 2018: Brain Injury: [BI]
Jennifer A Kosty, Shawn M Stevens, Yair M Gozal, Vincent A DiNapoli, Smruti K Patel, Justin S Golub, Norberto O Andaluz, Myles Pensak, Mario Zuccarello, Ravi N Samy
BACKGROUND: The middle cranial fossa (MCF) approach is a challenging surgical technique for the resection of small and intermediate sized, primarily intracanalicular, vestibular schwannomas (VS), with the goal of hearing preservation (HP). OBJECTIVE: To describe a decade-long, single institutional experience with the MCF approach for resection of VS. METHODS: This is a retrospective cohort study of 63 patients who underwent the MCF approach for resection of VS from 2006 to 2016...
June 8, 2018: Operative Neurosurgery (Hagerstown, Md.)
G E Gondolesi, N F Aguirre, D A Ramisch, F A Mos, N F Pedraza, M R Fortunato, L M Gutiérrez, H Fraguas, R Marrugat, G E Rabin, C Musso, P A Farinelli, P H L Barros Schelotto, P M Raffaele
BACKGROUND: Simultaneous pancreas-kidney transplantation (SPK) has become the treatment of choice for type 1 diabetes mellitus (T1DM) patients with chronic renal failure. Type 2 diabetes mellitus (T2DM), was once considered to be a contraindication for pancreas transplantation; however, it has been accepted as a new indication, under strict criteria. Although favorable results have increase the indication for T2DM in developed countries, there have been no reports of long-term results for this indication from Latin American centers...
June 2018: Transplantation Proceedings
Selena Gimenez-Ibanez, Dagmar R Hann, Jeff H Chang, Cécile Segonzac, Thomas Boller, John P Rathjen
The plant pathogen Pseudomonas syringae injects about 30 different virulence proteins, so-called effectors, via a type III secretion system into plant cells to promote disease. Although some of these effectors are known to suppress either pattern-triggered immunity (PTI) or effector-triggered immunity (ETI), the mode of action of most of them remains unknown. Here, we used transient expression in Nicotiana benthamiana , to test the abilities of type III effectors of Pseudomonas syringae pv. tomato ( Pto ) DC3000 and Pseudomonas syringae pv...
2018: Frontiers in Plant Science
Matan Mekayten, Vladimir Yutkin, Mordechai Duvdevani, Dov Pode, Guy Hidas, Ezekiel H Landau, Fadi Youssef, Ofer N Gofrit
Background: Bladder recurrence after nephroureterectomy (NU) is common. However, there is no acceptable policy of adjuvant intravesical treatment after NU. Objective: To assess the rate of bladder recurrence following NU and to identify the high-risk subgroups that may become candidates for adjuvant intravesical therapy after NU. Patients and methods: Ninety-one patients (mean age 66.4 years) underwent NU. High-grade (HG) tumors were found in 63 patients and low-grade (LG) tumors in 28...
2018: Research and Reports in Urology
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