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https://www.readbyqxmd.com/read/29667085/long-term-hearing-outcomes-after-gamma-knife-surgery-in-patients-with-vestibular-schwannoma-with-hearing-preservation-evaluation-in-92-patients-with-serial-audiograms
#1
Toshinori Hasegawa, Takenori Kato, Takashi Yamamoto, Takehiro Naito, Naoki Kato, Jun Torii, Kazuki Ishii
The treatment strategy for patients with vestibular schwannoma (VS) is controversial, and data concerning the long-term hearing outcomes > 5 years after gamma knife surgery (GKS) are limited. The long-term hearing outcomes after GKS were evaluated in VS patients with hearing preservation. Ninety-two VS patients with a pure tone average (PTA) ≤ 50 dB were evaluated. The median age was 54 years; the median tumor volume was 1.5 cm3 . The tumors were treated with a median margin dose of 12 Gy and a median mean cochlear dose of 4...
April 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29665536/the-effect-of-percutaneous-transluminal-angioplasty-of-superficial-femoral-artery-on-pulse-wave-features
#2
Mikko Peltokangas, Velipekka Suominen, Damir Vakhitov, Jarmo Verho, Janne Korhonen, Jukka Lekkala, Antti Vehkaoja, Niku Oksala
We aimed to analyze the effects of percutaneous transluminal angioplasty (PTA) of the superficial femoral artery (SFA) on arterial pulse waves (PWs). Altogether 24 subjects i.e. 48 lower limbs were examined including 26 treated lower limbs having abnormal ankle-to-brachial pressure index (ABI) (ABI<0.9 or ABI>1.3) and 22 non-treated lower limbs. The measurements were conducted in pre-, peri- and post-treatment phases as well as in follow-up visit after 1 month. Both ABI and toe pressures measured by standard equipment were used as reference values...
April 6, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29663052/magnetic-particle-imaging-guided-real-time-percutaneous-transluminal-angioplasty-in-a-phantom-model
#3
Stefan Herz, Patrick Vogel, Philipp Dietrich, Thomas Kampf, Martin A Rückert, Ralph Kickuth, Volker C Behr, Thorsten A Bley
PURPOSE: To investigate the potential of real-time magnetic particle imaging (MPI) to guide percutaneous transluminal angioplasty (PTA) of vascular stenoses in a phantom model. MATERIALS AND METHODS: Experiments were conducted on a custom-built MPI scanner. Vascular stenosis phantoms consisted of polyvinyl chloride tubes (inner diameter 8 mm) prepared with a centrally aligned cable tie to form ~ 50% stenoses. MPI angiography for visualization of stenoses was performed using the superparamagnetic iron oxide nanoparticle-based contrast agent Ferucarbotran (10 mmol (Fe)/l)...
April 16, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29655372/population-pharmacokinetics-pharmacodynamics-of-micafungin-against-candida-species-in-obese-critically-ill-and-morbidly-obese-critically-ill-patients
#4
Emilio Maseda, Santiago Grau, Sonia Luque, Maria-Pilar Castillo-Mafla, Alejandro Suárez-de-la-Rica, Ana Montero-Feijoo, Patricia Salgado, Maria-Jose Gimenez, Carlos A García-Bernedo, Fernando Gilsanz, Jason A Roberts
BACKGROUND: Dosing in obese critically ill patients is challenging due to pathophysiological changes derived from obesity and/or critical illness, and it remains fully unexplored. This study estimated the micafungin probability of reaching adequate 24-h area under the curve (AUC0-24h )/minimum inhibitory concentration (MIC) values against Candida spp. for an obese/nonobese, critically ill/noncritically ill, large population. METHODS: Blood samples for pharmacokinetic analyses were collected from 10 critically ill nonobese patients, 10 noncritically ill obese patients, and 11 critically ill morbidly obese patients under empirical/directed micafungin treatment...
April 15, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29649596/population-pharmacokinetics-and-pharmacodynamics-of-fosfomycin-in-non-critically-ill-patients-with-bacteremic-urinary-infection-caused-by-multidrug-resistant-escherichia-coli
#5
Vicente Merino-Bohorquez, Fernando Docobo-Pérez, Jesús Sojo, Isabel Morales, Carmen Lupión, Dolores Martín, Manuel Cameán, William Hope, Álvaro Pascual, Jesús Rodríguez-Baño
The aim of the present study was to describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection (B-UTI). The analysis identified optimal regimens, based on pharmacodynamic targets and assessed the adequacy of CLSI and EUCAST susceptibility breakpoints for Escherchia coli. MethodsSixteen patients with B-UTI caused by multidrug-resistant E. coli, (FOREST clinical trial) received intravenous fosfomycin (4g/Q6h) were analysed. A population pharmacokinetic analysis was performed, and Monte Carlo simulations were undertaken using 4g/Q6h or 8g/Q8h...
April 9, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29649042/factors-associated-with-the-benefits-of-concurrent-administration-of-intratympanic-steroid-injection-with-oral-steroids-in-patients-with-acute-acoustic-trauma
#6
Young-Soo Chang, Kanghyun Bang, Nayeon Choi, Jong Sei Kim, Gang-Gyu Lee
OBJECTIVE: To analyze the factors associated with the benefits of concurrent administration of intratympanic steroid injection (ITSI) and oral steroids in patients with acute acoustic trauma (AAT) incurred during military training. STUDY DESIGN: Retrospective analysis. PATIENTS: Nineteen patients eligible under the criteria established concerning treatment for AAT were retrospectively reviewed in this study. INTERVENTIONS: ITSI treatments were administered simultaneously alongside oral prednisolone...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29648959/the-feasibility-of-telephone-administered-cognitive-testing-in-individuals-1-and-2-years-after-inpatient-rehabilitation-for-traumatic-brain-injury
#7
Kristen Dams-O'Connor, Karla Therese L Sy, Alexandra Landau, Yelena Bodien, Sureyya Dikmen, Elizabeth R Felix, Joseph T Giacino, Laura Gibbons, Flora M Hammond, Tessa Hart, Doug Johnson-Greene, Jeannie Lengenfelder, Anthony Lequerica, Jody Newman, Thomas Novack, Therese M O'Neil-Pirozzi, Gale Whiteneck
Traumatic brain injury (TBI) often results in cognitive impairment, and trajectories of cognitive functioning can vary tremendously over time across survivors. Traditional approaches to measuring cognitive performance require face-to-face administration of a battery of objective neuropsychological tests, which can be time- and labor-intensive. There are numerous clinical and research contexts in which in-person testing is undesirable or unfeasible, including clinical monitoring of older adults or individuals with disability for whom travel is challenging, and epidemiological studies of geographically dispersed participants...
March 13, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29644481/efficacious-cefazolin-prophylactic-dose-for-morbidly-obese-women-undergoing-bariatric-surgery-based-on-evidence-from-subcutaneous-microdialysis-and-populational-pharmacokinetic-modeling
#8
Eduardo Celia Palma, Nelson Guardiola Meinhardt, Airton Tetelbom Stein, Isabela Heineck, Maria Isabel Fischer, BibianaVerlindo de Araújo, Teresa Dalla Costa
PURPOSE: To determine the efficacious cefazolin prophylactic dose for bariatric surgery using free subcutaneous concentrations accessed by microdialysis after 2 g or 3 g i.v. bolus dosing to morbidly obese women and POPPK modeling. METHODS: A POPPK model with variable plasma and subcutaneous tissue protein binding was developed to simultaneously describe plasma and tissue data sets. The outcomes was predicted for common surgical site infection (SSI) bacteria over 3, 4, 5 and 6 h periods postdose, as probability of target attainment (PTA) using Monte Carlo simulation...
April 11, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29644162/clinical-study-on-middle-ear-diseases-in-children-with-orofacial-clefts
#9
Raja Kalaiarasi, Kamran A Syed, Chellappa Vijayakumar, Ajoy M Varghese, Mary John
Introduction Orofacial clefts are associated with middle ear diseases, but the magnitude of this problem is not generally well appreciated. The aim of this study was to describe the middle ear findings and audiological profile in children with orofacial clefts. Materials and methods Children with orofacial clefts attending plastic surgery and otorhinolaryngology departments of a tertiary hospital over one-year duration were included in this study. Ninety-six children with orofacial clefts were identified. They were categorized age-wise as zero to five years, more than five years to 10 years, and more than 10 years to 15 years...
February 8, 2018: Curēus
https://www.readbyqxmd.com/read/29619852/manganese-in-toenails-is-associated-with-hearing-loss-at-high-frequencies-in-humans
#10
Nobutaka Ohgami, Xiang Li, Ichiro Yajima, Reina Oshino, Kyoko Ohgami, Yoko Kato, Nazmul Ahsan, Anwarul Azim Akhand, Masashi Kato
PURPOSE: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans...
April 10, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29611173/the-relationship-between-pulse-waveform-analysis-indices-endothelial-function-and-clinical-outcomes-in-patients-with-peripheral-artery-disease-treated-using-percutaneous-transluminal-angioplasty-during-a-one-year-follow-up-period
#11
Paweł S Kaczmarczyk, Paweł Maga, Rafał Niżankowski, Rafał Januszek, Marzena Frołow, Mikołaj Maga, Jolanta Kościelniak, Andrzej Belowski
BACKGROUND: The aim of the current study was to assess the relationship between potential predictors of clinical outcomes after percutaneous transluminal angioplasty (PTA) of peripheral arteries during a one-year follow-up. Indices of endothelial function (EF), arterial pulse waveform analysis (aPWA) and markers of peripheral arteries ischemia were among those mostly examined. METHODS: The study comprised of 72 individuals with PAD who underwent PTA of the peripheral arteries...
April 3, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29606758/some-microbiological-physicochemical-and-ripening-properties-of-erzincan-tulum-cheese-produced-with-added-black-cumin-nigella-sativa-l
#12
Yusuf Çakır, Songül Çakmakçı
The effects of black cumin (BC) at 0, 1 or 2% in Erzincan Tulum cheese (Tulum cheese) on its microbiological, chemical and proteolysis properties during ripening were investigated. The addition of BC caused an increase in the dry matter, protein, ash, total nitrogen (TN), water-soluble nitrogen (WSN) (% of TN) (ripening index), 5% phosphotungstic acid soluble nitrogen (PTA-SN) (% of TN), and 12% trichloroacetic acid soluble nitrogen (TCA-SN) (% of TN) concentrations compared to BC-free (control) cheese. Additionally, the addition of BC caused a decrease in coliforms, yeasts & moulds, fat-in-dry matter (FDM), pH, and acidity...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29605355/a-functional-and-anatomical-comparison-between-two-passive-transcutaneous-bone-conduction-implants-in-children
#13
Sara Giannantonio, Alessandro Scorpecci, Concettina Pacifico, Pasquale Marsella
OBJECTIVE: To compare anatomical and functional outcomes of two passive transcutaneous bone conduction implant systems: Sophono™ and BAHA Attract™. MATERIALS AND METHODS: Twenty patients, affected by bilateral conductive hearing loss, underwent unilateral transcutaneous bone conduction implant surgery. Ten children received a Sophono™ implant (6 males, 4 females, mean age 11 years, mean unaided Pure Tone Average (PTA) 0.25-4kHz = 69.70dB HL) and 10 a BAHA Attract™ system (7 males, 3 females, mean age 19 years, mean unaided PTA0...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29594079/sudden-bilateral-sensorineural-hearing-loss-secondary-to-cerebral-venous-thrombosis
#14
Muhammad-Nu'aim Ishak, Nik-Mohd-Syukra Nik-Abdul-Ghani, Irfan Mohamad
Introduction: Sudden sensorineural hearing loss (SSNHL) is an important otological emergency. Up to 90% of the cases are idiopathic. Cerebral venous thrombosis (CVT) is an extremely rare identifiable cause as it only represents 0.5% of all strokes. Case Report: In this paper, an unusual case of bilateral SSNHL secondary to bilateral CVT with rapid and complete recovery is reported. The patient presented with sudden bilateral hearing loss associated with some neurological symptoms...
March 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29587341/expression-of-pinellia-pedatisecta-lectin-gene-in-transgenic-wheat-enhances-resistance-to-wheat-aphids
#15
Xiaoliang Duan, Qiling Hou, Guoyu Liu, Xiaomeng Pang, Zhenli Niu, Xiao Wang, Yufeng Zhang, Baoyun Li, Rongqi Liang
Wheat aphids are major pests during the seed filling stage of wheat. Plant lectins are toxic to sap-sucking pests such as wheat aphids. In this study, Pinellia pedatisecta agglutinin ( ppa ), a gene encoding mannose binding lectin, was cloned, and it shared 92.69% nucleotide similarity and 94% amino acid similarity with Pinellia ternata agglutinin ( pta ). The ppa gene, driven by the constitutive and phloem-specific ribulose bisphosphate carboxylase small subunit gene ( rbcs ) promoter in pBAC-rbcs-ppa expression vector, was transferred into the wheat cultivar Baofeng104 (BF104) by particle bombardment transformation...
March 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29587275/efficacy-analysis-of-capsaicin-8-patch-in-neuropathic-peripheral-pain-treatment
#16
Joana Tenreiro Pinto, Frederico C Pereira, Maria C Loureiro, Ricardo Gama, Hugo L Fernandes
BACKGROUND/AIMS: Several guidelines for neuropathic pain management and various effective drugs are available; however, neuropathic pain remains undertreated. This retrospective study aimed to evaluate the efficacy of topical capsaicin 8% in peripheral neuropathic pain in a routine clinical setting. METHODS: Therapeutic efficacy was evaluated through pain intensity, using numerical pain rating scale at baseline and 7-14 days after each treatment, and using pain treatment area (PTA) assessed immediately before each treatment...
March 27, 2018: Pharmacology
https://www.readbyqxmd.com/read/29582126/endovascular-treatment-of-haemodialysis-arteriovenous-fistula-with-drug-coated-balloon-angioplasty-a-single-centre-study
#17
Jernej Lučev, Silva Breznik, Dejan Dinevski, Robert Ekart, Mitja Rupreht
PURPOSE: To evaluate the effect of percutaneous transluminal angioplasty (PTA) on haemodialysis fistulas utilising drug-coated balloons with plain balloon vessel preparation (DCB). MATERIALS AND METHODS: In the study group, 31 patients (16 men; mean age 62.8 ± 17.2 years) with failing arteriovenous fistulas were treated, with DCB, and compared with a control group (31 patients; 15 men; mean age 67.0 ± 8.44 years), in which only plain balloon PTA was performed...
March 26, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29579214/temocillin-dosing-in-haemodialysis-patients-based-on-population-pharmacokinetics-of-total-and-unbound-concentrations-and-monte-carlo-simulations
#18
Ana C Miranda Bastos, Stefaan J Vandecasteele, Anne Spinewine, Paul M Tulkens, Françoise Van Bambeke
Objectives: To develop a population model describing temocillin pharmacokinetics (PK) in patients undergoing haemodialysis and investigate how pharmacokinetic/pharmacodynamic (PD) targets can be met with different dosage regimens. Patients and methods: Sixteen patients received the currently licenced dosing of 1, 2 or 3 g of temocillin (total of 61 doses) corresponding to an inter-dialytic period of 20, 44 or 68 h, respectively, and a dialysis period of 4 h...
March 22, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29573806/differing-genetic-trend-estimates-from-traditional-and-genomic-evaluations-of-genotyped-animals-as-evidence-of-preselection-bias-in-us-holsteins
#19
Y Masuda, P M VanRaden, I Misztal, T J Lawlor
The objective of this study was to compare genetic trends from single-step genomic BLUP (ssGBLUP) and traditional BLUP models for milk production traits of US Holsteins. Phenotypes were 305-d milk, fat, and protein yields from 21,527,040 cows recorded between January 1990 and August 2015. The pedigree file included 29,651,623 animals and was limited to 3 generations back from recorded or genotyped animals. Genotypes for 764,029 animals were used, and analyses were by a 3-trait repeatability model as used in the US official genetic evaluation...
March 21, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29573541/treatment-of-infrapopliteal-post-pta-dissection-with-tack-implants-12-month-results-from-the-toba-btk-study
#20
Marianne Brodmann, Christian Wissgott, Andrew Holden, Robert Staffa, Thomas Zeller, Thodur Vasudevan, Peter Schneider
OBJECTIVES: The Tack implant is designed for focal, minimal metal management of dissections. This study evaluated Tacks for treating postpercutaneous transluminal angioplasty (PTA) dissection in patients with below-the-knee (BTK) arterial occlusive disease. BACKGROUND: PTA is the most commonly used endovascular treatment for patients with occlusive disease of the BTK vessels. Post-PTA dissection is a significant clinical problem that results in poor outcomes, but currently there are limited treatment options for managing dissections...
March 24, 2018: Catheterization and Cardiovascular Interventions
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