Read by QxMD icon Read


Darren Grimwood, Jane Harvey-Lloyd
BACKGROUND: Intramedullary nailing is the standard surgical treatment for mid-diaphyseal fractures of long bones; however, it is also a high radiation dose procedure. Distal locking is regularly cited as a demanding element of the procedure, and there remains a reliance on X-ray fluoroscopy to locate the distal holes. A recently developed electromagnetic navigation (EMN) system allows radiation-free distal locking, with a virtual on-screen image. OBJECTIVE: To compare operative duration, fluoroscopy time and radiation dose when using EMN over fluoroscopy, for the distal locking of intramedullary nails...
August 25, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Dayane M Silva, José L R Martins, Iziara F Florentino, Danillo R Oliveira, James O Fajemiroye, Leonice M F Tresnvenzol, José R Paula, Elson A Costa
Memora nodosa is popularly known as "caroba" and widely found in the Cerrado regions of Brazil. In traditional medicine, the leaves and stems are used for the healing of external ulcer and the roots for abdominal pain. This study investigated the effect of ethanolic roots extract of Memora nodosa (EMN) on the gastric mucosa of mice. In the indomethacin induced gastric ulcer model, the treatments of the animals with EMN at doses of 100, 300 and 1000 mg/kg, p.o., markedly reduced the index of lesions. In the gastric ulcer models induced by ethanol and cold restraint-stress the previous treatment with EMN at dose of 300 mg/kg showed 69% and 43% of protection, respectively...
July 11, 2016: Anais da Academia Brasileira de Ciências
Luis Escriche-Tur, Mercè Font-Bardia, Belén Albela, Montserrat Corbella
Five new dinuclear Mn(iii) compounds with benzoato derivative bridges [{Mn(bpy)L}2(μ-O)(μ-n-RC6H4COO)2]X2 (n-R = 3-MeO, 4-MeO and 4-tBu, X = NO3(-) and ClO4(-)) were synthesised and characterised. According to X-ray diffraction, the X anions tend to be coordinated to the Mn ions and may occupy the place of the monodentate ligand L. Two structural isomers that only differ in one of their monodentate ligands have been obtained with the 3-MeOC6H4COO(-) bridges. For all compounds, the Mn(iii) ions display elongated octahedra with a pronounced rhombic distortion...
July 19, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Renata Kiyomi Kishimoto, Sarah Lee Vaughan Vulcani de Freitas, Cristina Alonso Ratis, Daniela Borri, Roberta Sitnik, Elvira Deolinda Rodrigues Pereira Velloso
BACKGROUND: Multiple myeloma is a plasma cell neoplasm with acquired genetic abnormalities of clinical and prognostic importance. Multiple myeloma differs from other hematologic malignancies due to a high fraction of low proliferating malignant plasma cells and the paucity of plasma cells in bone marrow aspiration samples, making cytogenetic analysis a challenge. An abnormal karyotype is found in only one-third of patients with multiple myeloma and interphase fluorescence in situ hybridization is the most useful test for studying the chromosomal abnormalities present in almost 90% of cases...
April 2016: Revista Brasileira de Hematologia e Hemoterapia
Iziara F Florentino, Daiany P B Silva, Pablinny M Galdino, Roberta C Lino, José L R Martins, Dayane M Silva, José R de Paula, Leonice M F Tresvenzol, Elson A Costa
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves and stems bark of Memora nodosa (Silva Manso) Miers (Bignoniaceae) are used in Brazilian traditional medicine in the treatment of external ulcers and wounds; its roots are used to treat abdominal pain and scabies. AIM OF THE STUDY: Our aim was to evaluate the antinociceptive and anti-inflammatory activities of Memora nodosa roots ethanolic extract (EMN) and allantoin, a secondary metabolite isolated from this plant. MATERIALS AND METHODS: The EMN and allantoin antinociceptive activity were evaluated in mice using both chemical and heat-induced pain models such as acetic acid-induced writhing, formalin and tail-flick tests...
June 20, 2016: Journal of Ethnopharmacology
Emne Ali Abdallah, Marcello Ferretti Fanelli, Virgílio Souza E Silva, Marcelo Calil Machado Netto, José Luiz Gasparini Junior, Daniel Vilarim Araújo, Luciana Menezes Mendonça Ocea, Marcilei Eliza Cavicchioli Buim, Milena Shizue Tariki, Vanessa da Silva Alves, Victor Piana de Andrade, Aldo Lourenço Abbade Dettino, Celso Abdon Lopes de Mello, Ludmilla Thomé Domingos Chinen
Circulating tumor cells are important markers of tumor progression and can reflect tumor behavior in metastatic colorectal cancer (mCRC). Identification of proteins that confer resistance to treatment is an important step to predict response and better selection of treatment for patients. Multidrug resistance-associated protein 1 (MRP1) and Multidrug resistance-associated protein 4 (MRP4) play a role in irinotecan-resistance, and Excision Repair Cross-Complementation group 1 (ERCC1) expression can confer resistance to platinum compounds...
August 15, 2016: International Journal of Cancer. Journal International du Cancer
(no author information available yet)
No abstract text is available yet for this article.
March 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
D Gallego, O Ortega, C Arenas, I López, E Mans, P Clavé
BACKGROUND: Levosulpiride is a 5HT4 agonist/D2 antagonist prokinetic agent used to improve gastric emptying in patients with functional dyspepsia or gastroparesis. The aim of this study was to characterize its effect on the main in vitro motility patterns in the human fundus, antrum, and jejunum. METHODS: Circular muscle strips from human stomach (antrum and fundus) and jejunum, obtained from 46 patients undergoing bariatric surgery, were studied using organ baths...
June 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Lu-Feng Shi, Laura L Koenig
OBJECTIVE: Non-native listeners do not recognize English sentences as effectively as native listeners, especially in noise. It is not entirely clear to what extent such group differences arise from differences in relative weight of semantic versus syntactic cues. This study quantified the use and weighting of these contextual cues via Boothroyd and Nittrouer's j and k factors. The j represents the probability of recognizing sentences with or without context, whereas the k represents the degree to which context improves recognition performance...
July 2016: Ear and Hearing
K A Lusta
The review summarizes the comprehensive biochemical and physicochemical characteristics of extracellular membrane nanovesicles (EMN) derived from different kinds of bacteria. The EMN structure, composition, biogenesis, secretion mechanisms, formation conditions, functions, involvement in pathogenesis, and application in biotechnology and medicine are discussed.
September 2015: Prikladnaia Biokhimiia i Mikrobiologiia
Daniel P Steinfort, Asha Bonney, Katharine See, Louis B Irving
Multiple guidance modalities may be combined during bronchoscopic investigation of peripheral pulmonary lesions (PPLs). The relative contribution of each modality to diagnostic performance remains uncertain.Endobronchial ultrasound (EBUS) with virtual bronchoscopy (VB) was routinely performed, with electromagnetic navigation (EMN) utilised only where EBUS was unable to locate PPLs or where the probe was adjacent to the lesion and on-site cytologic examination was nondiagnostic.236 consecutive patients with 245 PPLs had lesion size 22...
February 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Georg Ruile, Anatoli Djanatliev, Christine Kriza, Florian Meier, Ines Leb, Willi A Kalender, Peter L Kolominsky-Rabas
AIMS: The potential of dedicated Breast-CT is evaluated by simulating its impact onto the performance of the German breast cancer screening program. Attendance rates, cancer detection and economic implications are quantified. METHODS: Based on a prospective health technology assessment approach, we simulated screening in different scenarios. RESULTS: In the simulation, attendance rates increase from 54 to up to 72% due to reduced pain. Breast cancers will be detected earlier while nodal positives and distant recurrences decrease...
November 2015: Journal of Comparative Effectiveness Research
Z Czapla, S M McPhail
The present study examined whether a specific property of cell microstructures may be useful as a biomarker of aging. Specifically, the association between age and changes of cellular structures reflected in electrophoretic mobility of cell nuclei index (EMN index) values across the adult lifespan was examined. This report considers findings from cross sections of females (n=1273) aged 18-98 years, and males (n=506) aged 19-93 years. A Biotest apparatus was used to perform intracellular microelectrophoresis on buccal epithelial cells collected from each individual...
December 2015: Homo: Internationale Zeitschrift Für die Vergleichende Forschung Am Menschen
David E Ost, Armin Ernst, Xiudong Lei, Kevin L Kovitz, Sadia Benzaquen, Javier Diaz-Mendoza, Sara Greenhill, Jennifer Toth, David Feller-Kopman, Jonathan Puchalski, Daniel Baram, Raj Karunakara, Carlos A Jimenez, Joshua J Filner, Rodolfo C Morice, George A Eapen, Gaetane C Michaud, Rosa M Estrada-Y-Martin, Samaan Rafeq, Horiana B Grosu, Cynthia Ray, Christopher R Gilbert, Lonny B Yarmus, Michael Simoff
RATIONALE: Advanced bronchoscopy techniques such as electromagnetic navigation (EMN) have been studied in clinical trials, but there are no randomized studies comparing EMN with standard bronchoscopy. OBJECTIVES: To measure and identify the determinants of diagnostic yield for bronchoscopy in patients with peripheral lung lesions. Secondary outcomes included diagnostic yield of different sampling techniques, complications, and practice pattern variations. METHODS: We used the AQuIRE (ACCP Quality Improvement Registry, Evaluation, and Education) registry to conduct a multicenter study of consecutive patients who underwent transbronchial biopsy (TBBx) for evaluation of peripheral lesions...
January 1, 2016: American Journal of Respiratory and Critical Care Medicine
A Mokhtarpour, A A Naserian, F Pourmollae, M H Ghaffari
A lactation experiment was conducted to determine the influence of addition of pistachio by-products extract (PBE) to alfalfa silage (AS) on performance, rumen fermentation, milk yield and composition, and microbial nitrogen synthesis. Eight multiparous dairy goats (1.8 ± 0.25 kg of milk yield) were used in a replicated 4 × 4 Latin square design with a 2 × 2 factorial arrangement of treatments to compare two types of AS (supplemented with or without PBE) with two levels of dietary crude protein (14% vs...
August 2016: Journal of Animal Physiology and Animal Nutrition
Kenneth Hugdahl, Marcus E Raichle, Anish Mitra, Karsten Specht
In this paper we suggest the existence of a generalized task-related cortical network that is up-regulated whenever the task to be performed requires the allocation of generalized non-specific cognitive resources, independent of the specifics of the task to be performed. We have labeled this general purpose network, the extrinsic mode network (EMN) as complementary to the default mode network (DMN), such that the EMN is down-regulated during periods of task-absence, when the DMN is up-regulated, and vice versa...
2015: Frontiers in Human Neuroscience
Nadine Knutti, Michael Kuepper, Karlheinz Friedrich
EMMPRIN (extracellular matrix metalloproteinase inducer) is a widely expressed glycoprotein and a member of the immunoglobulin superfamily which exists in both a membrane-spanning and a soluble form. Homotypic interactions of EMMPRIN underlie its multiple roles in normal development and pathological situations such as viral infections, Alzheimer's disease and cancer. This study employed a recombinant soluble, fully glycosylated EMMPRIN domain (rhsEMN) as a tool to characterize the structural basis of EMMPRIN-EMMPRIN receptor (EMNR) contacts and their functional effects on MCF-7 breast carcinoma cells...
November 2015: FEBS Journal
Marcilei Ec Buim, Marcello F Fanelli, Virgilio S Souza, Juliana Romero, Emne A Abdallah, Celso Al Mello, Vanessa Alves, Luciana Mm Ocea, Natália B Mingues, Paula Nvp Barbosa, Chiang J Tyng, Rubens Chojniak, Ludmilla Td Chinen
BACKGROUND: Quantification of Circulating Tumor Cells (CTCs) as a prognostic marker in metastatic colorectal cancer (mCRC) has already been validated and approved for routine use. However, more than quantification, qualification or characterization of CTCs is gaining importance, since the genetic characterization of CTCs may reflect, in a real time fashion, genetic profile of the disease. OBJECTIVE: To characterize KRAS mutations (codon 12 and 13) in CTCs from patients with mCRC and to compare with matched primary tumor...
2015: Cancer Biology & Therapy
Andy C Rawstron, Bruno Paiva, Maryalice Stetler-Stevenson
Treatment options for myeloma continue to develop at a rapid pace, and it is becoming increasingly challenging to determine the optimal therapeutic approaches because demonstrating a clear survival benefit now requires many years of follow-up. The detection of minimal residual disease (MRD) is recognized as a sensitive and rapid approach to evaluate treatment efficacy that predicts progression-free and overall survival independent of categorical response assessment and patients' biology. The benefit of MRD analysis is reflected in the many different techniques (multiparameter flow cytometry, quantitative polymerase chain reaction, and high-throughput sequencing) and collaborative groups (including EMN, ESCCA, ICCS, EuroFlow, and EuroMRD) that have performed collaborative projects to harmonize quantitative MRD detection...
January 2016: Cytometry. Part B, Clinical Cytometry
Philip Wahlster, Mireille Goetghebeur, Christine Kriza, Charlotte Niederländer, Peter Kolominsky-Rabas
BACKGROUND: The diffusion of health technologies from translational research to reimbursement depends on several factors included the results of health economic analysis. Recent research identified several flaws in health economic concepts. Additionally, the heterogeneous viewpoints of participating stakeholders are rarely systematically addressed in current decision-making. Multi-criteria Decision Analysis (MCDA) provides an opportunity to tackle these issues. The objective of this study was to review applications of MCDA methods in decisions addressing the trade-off between costs and benefits...
2015: BMC Health Services Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"