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https://www.readbyqxmd.com/read/28815787/evaluation-of-incidence-significance-and-prognostic-role-of-circulating-tumor-microemboli-and-transforming-growth-factor-%C3%AE-receptor-i-in-head-and-neck-cancer
#1
Marcello Ferretti Fanelli, Thiago Bueno Oliveira, Alexcia Camila Braun, Marcelo Corassa, Emne Ali Abdallah, Ulisses Ribaldo Nicolau, Vanessa da Silva Alves, Daniel Garcia, Vinicius F Calsavara, Luiz Paulo Kowalski, Ludmilla Thomé Domingos Chinen
BACKGROUND: Circulating tumor microemboli (CTM) are clusters of circulating tumor cells (CTCs), involved in metastasis, as also transforming growth factor-β (TGF-β). The purpose of this study was to verify their role in progression-free survival (PFS). METHODS: Blood from patients with locally advanced head and neck squamous cell carcinoma (HNSCC; n = 53) was analyzed in 2 moments. TGF-β receptor I (TGF-βRI) expression was evaluated by immunocytochemistry...
August 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/28650620/influence-of-the-disposition-of-the-anisotropy-axes-into-the-magnetic-properties-of-mn-iii-dinuclear-compounds-with-benzoato-derivative-bridges
#2
Beltzane Garcia-Cirera, Silvia Gómez-Coca, Mercè Font-Bardia, Eliseo Ruiz, Montserrat Corbella
The two new Mn(III) dinuclear compounds [{Mn(H2O)(phen)}2(μ-4-CH3C6H4COO)2(μ-O)](ClO4)2·3CH3CN·H2O (1·3CH3CN·H2O) and [{Mn(H2O)(phen)}(μ-O)(μ-2-BrC6H4COO)2{Mn(NO3)(phen)}]NO3 (2) have been synthesized. Their structural data reveal significant differences in the shape of the coordination octahedron around the Mn(III) ions in both compounds. The different distortions from ideal geometry incite a very different magnetic behavior, affecting both the zero-field splitting parameters of the Mn(III) ions (DMn and EMn) and the magnetic interaction between them...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28628691/eruptive-melanocytic-acral-nevi-in-the-setting-of-6-mercaptopurine-therapy
#3
Arpan V Prabhu, Kristin Bibee, Joseph C English
<p>Eruptive melanocytic nevi (EMN) are a rare clinical finding characterized by sudden-onset nevi that often present in a grouped distribution. They have been associated with chemotherapy, immunosuppression, bullous diseases, and medications including multikinase and BRAF inhibitors. It is important for dermatologists to be able to identify patients with sudden development of new melanocytic nevi secondary to particular medications. Herein, we describe a case of eruptive melanocytic acral nevi secondary to 6-mercaptopurine therapy...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28560666/circulating-tumor-cells-as-cancer-biomarkers-in-the-clinic
#4
Ludmilla Thomé Domingos Chinen, Emne Ali Abdallah, Alexcia Camila Braun, Bianca de Cássia Troncarelli de Campos Parra Flores, Marcelo Corassa, Solange Moraes Sanches, Marcello Ferretti Fanelli
It is believed that the development of metastatic cancer requires the presence of circulating tumor cells (CTCs) , which are found in a patient's circulation as rare abnormal cells comingled with billions of the normal red and white blood cells. The systems developed for detection of CTCs have brought progress to cancer treatment. The molecular characterization of CTCs can aid in the development of new drugs, and their presence during treatment can help clinicians determine the prognosis of the patient. Studies have been carried out in patients early in the disease course, with only primary tumors, and the role of CTCs in prognosis seems to be as important as it is in patients with metastatic disease...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28492593/eruptive-melanocytic-nevi-during-azathioprine-therapy-for-antisynthetase-syndrome
#5
Stephanie A Steinweg, Christian R Halvorson, Grace F Kao, Sridhar Dronavalli
Eruptive melanocytic nevi (EMN) are rare multiple benign melanocytic nevi that develop within a few months. The phenomenon has been associated with a variety of dermatologic and systemic conditions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, epidermolysis bullosa, Addison disease, human immunodeficiency virus infection, and internal malignancy, among others. It also is commonly attributed to medications, particularly immunosuppressive and chemotherapeutic agents. We report a case of EMN in a 50-year-old man undergoing azathioprine therapy for antisynthetase syndrome...
April 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28400894/surgical-suturing-induced-melanocytic-nevi-a-new-type-of-eruptive-melanocytic-nevi
#6
Alexander C Katoulis, Dimitrios Sgouros, Giuseppe Argenziano, Efstathios Rallis, Ioannis Panayiotides, Dimitrios Rigopoulos
BACKGROUND: Nevogenesis is a complex process involving several pathogenetic mechanisms, including genetic factors, hormonal influences and UV-radiation. Trauma has been described as a triggering factor for an alternative pathway of nevogenesis. Eruptive melanocytic nevi (EMN), related either to immunosuppression or to blistering disorders, represent a special type of nevi probably induced by the disruption of the dermo-epidermal junction and consequent proliferation of quiescent pigment cells during re-epithelization...
November 30, 2016: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/28089582/a-model-for-screening-and-prioritizing-consumer-nanoproduct-risks-a-case-study-from-south-africa
#7
Ndeke Musee
The potential risks of the increasing variety and volume of engineered nanomaterials (ENMs) entering into the ecosystem remain poorly quantified. In recent years, information essential to evaluate the ecological risks of ENMs has increased. However, the data are highly fragmented, limited, or severely lacking. This limits the usefulness of the information to support holistic screening and prioritization of potentially harmful ENMs. To screen and prioritize ENMs risks, we adopted a two-phased approach. First, a holistic framework model was developed to integrate a diverse set of factors aimed to assess the potential hazard, exposure, and in turn, risk to the ecosystem of ENMs from a given consumer nanoproduct...
January 12, 2017: Environment International
https://www.readbyqxmd.com/read/28048567/su-c-bra-07-variability-of-patient-specific-motion-models-derived-using-different-deformable-image-registration-algorithms-for-lung-cancer-stereotactic-body-radiotherapy-sbrt-patients
#8
S Dhou, D Ionascu, J Lewis, C Williams
PURPOSE: To study the variability of patient-specific motion models derived from 4-dimensional CT (4DCT) images using different deformable image registration (DIR) algorithms for lung cancer stereotactic body radiotherapy (SBRT) patients. METHODS: Motion models are derived by 1) applying DIR between each 4DCT image and a reference image, resulting in a set of displacement vector fields (DVFs), and 2) performing principal component analysis (PCA) on the DVFs, resulting in a motion model (a set of eigenvectors capturing the variations in the DVFs)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28008271/early-detection-of-poor-outcome-in-patients-with-metastatic-colorectal-cancer-tumor-kinetics-evaluated-by-circulating-tumor-cells
#9
Virgílio Souza E Silva, Ludmilla Thomé Domingos Chinen, Emne A Abdallah, Aline Damascena, Jociana Paludo, Rubens Chojniak, Aldo Lourenço Abbade Dettino, Celso Abdon Lopes de Mello, Vanessa S Alves, Marcello F Fanelli
BACKGROUND: Colorectal cancer (CRC) is the third most prevalent cancer worldwide. New prognostic markers are needed to identify patients with poorer prognosis, and circulating tumor cells (CTCs) seem to be promising to accomplish this. PATIENTS AND METHODS: A prospective study was conducted by blood collection from patients with metastatic CRC (mCRC), three times, every 2 months in conjunction with image examinations for evaluation of therapeutic response. CTC isolation and counting were performed by Isolation by Size of Epithelial Tumor Cells (ISET)...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28008174/autologous-transplant-vs-oral-chemotherapy-and-lenalidomide-in-newly-diagnosed-young-myeloma-patients-a-pooled-analysis
#10
COMPARATIVE STUDY
F Gay, S Oliva, M T Petrucci, V Montefusco, C Conticello, P Musto, L Catalano, A Evangelista, S Spada, P Campbell, R Ria, M Salvini, M Offidani, A M Carella, P Omedé, A M Liberati, R Troia, A M Cafro, A Malfitano, A P Falcone, T Caravita, F Patriarca, A Nagler, A Spencer, R Hajek, A Palumbo, M Boccadoro
In newly diagnosed myeloma patients, upfront autologous transplant (ASCT) prolongs progression-free survival 1 (PFS1) compared with chemotherapy plus lenalidomide (CC+R). Salvage ASCT at first relapse may still effectively rescue patients who did not receive upfront ASCT. To evaluate the long-term benefit of upfront ASCT vs CC+R and the impact of salvage ASCT in patients who received upfront CC+R, we conducted a pooled analysis of 2 phase III trials (RV-MM-209 and EMN-441). Primary endpoints were PFS1, progression-free survival 2 (PFS2), overall survival (OS)...
August 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27789457/a-model-of-the-enteric-neural-circuitry-underlying-the-generation-of-rhythmic-motor-patterns-in-the-colon-the-role-of-serotonin
#11
REVIEW
Terence Keith Smith, Sang Don Koh
We discuss the role of multiple cell types involved in rhythmic motor patterns in the large intestine that include tonic inhibition of the muscle layers interrupted by rhythmic colonic migrating motor complexes (CMMCs) and secretomotor activity. We propose a model that assumes these motor patterns are dependent on myenteric descending 5-hydroxytryptamine (5-HT, serotonin) interneurons. Asynchronous firing in 5-HT neurons excite inhibitory motor neurons (IMNs) to generate tonic inhibition occurring between CMMCs...
January 1, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27779105/minimal-residual-disease-after-transplantation-or-lenalidomide-based-consolidation-in-myeloma-patients-a-prospective-analysis
#12
Stefania Oliva, Manuela Gambella, Milena Gilestro, Vittorio Emanuele Muccio, Francesca Gay, Daniela Drandi, Simone Ferrero, Roberto Passera, Chiara Pautasso, Annalisa Bernardini, Mariella Genuardi, Francesca Patriarca, Elona Saraci, Maria Teresa Petrucci, Norbert Pescosta, Anna Marina Liberati, Tommaso Caravita, Concetta Conticello, Alberto Rocci, Pellegrino Musto, Mario Boccadoro, Antonio Palumbo, Paola Omedè
We analyzed 50 patients who achieved at least a very good partial response in the RV-MM-EMN-441 study. Patients received consolidation with autologous stem-cell transplantation (ASCT) or cyclophosphamide-lenalidomide-dexamethasone (CRD), followed by Lenalidomide-based maintenance. We assessed minimal residual disease (MRD) by multi-parameter flow cytometry (MFC) and allelic-specific oligonucleotide real-time quantitative polymerase chain reaction (ASO-RQ-PCR) after consolidation, after 3 and 6 courses of maintenance, and thereafter every 6 months until progression...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/27562588/reducing-intraoperative-duration-and-ionising-radiation-exposure-during-the-insertion-of-distal-locking-screws-of-intramedullary-nails-a-small-scale-study-comparing-the-current-fluoroscopic-method-against-radiation-free-electromagnetic-navigation
#13
COMPARATIVE STUDY
Darren Grimwood, Jane Harvey-Lloyd
BACKGROUND: Intramedullary nailing is the standard surgical treatment for mid-diaphyseal fractures of long bones; however, it is also a high radiation dose procedure. Distal locking is regularly cited as a demanding element of the procedure, and there remains a reliance on X-ray fluoroscopy to locate the distal holes. A recently developed electromagnetic navigation (EMN) system allows radiation-free distal locking, with a virtual on-screen image. OBJECTIVE: To compare operative duration, fluoroscopy time and radiation dose when using EMN over fluoroscopy, for the distal locking of intramedullary nails...
December 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27411070/the-gastroprotective-effect-of-memora-nodosa-roots-against-experimental-gastric-ulcer-in-mice
#14
Dayane M Silva, José L R Martins, Iziara F Florentino, Danillo R Oliveira, James O Fajemiroye, Leonice M F Tresnvenzol, José R Paula, Elson A Costa
Memora nodosa is popularly known as "caroba" and widely found in the Cerrado regions of Brazil. In traditional medicine, the leaves and stems are used for the healing of external ulcer and the roots for abdominal pain. This study investigated the effect of ethanolic roots extract of Memora nodosa (EMN) on the gastric mucosa of mice. In the indomethacin induced gastric ulcer model, the treatments of the animals with EMN at doses of 100, 300 and 1000 mg/kg, p.o., markedly reduced the index of lesions. In the gastric ulcer models induced by ethanol and cold restraint-stress the previous treatment with EMN at dose of 300 mg/kg showed 69% and 43% of protection, respectively...
2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27295557/new-insights-into-the-comprehension-of-the-magnetic-properties-of-dinuclear-mn-iii-compounds-with-the-general-formula-mnl-nn-2-%C3%AE-o-%C3%AE-n-rc6h4coo-2-x2
#15
Luis Escriche-Tur, Mercè Font-Bardia, Belén Albela, Montserrat Corbella
Five new dinuclear Mn(iii) compounds with benzoato derivative bridges [{Mn(bpy)L}2(μ-O)(μ-n-RC6H4COO)2]X2 (n-R = 3-MeO, 4-MeO and 4-tBu, X = NO3(-) and ClO4(-)) were synthesised and characterised. According to X-ray diffraction, the X anions tend to be coordinated to the Mn ions and may occupy the place of the monodentate ligand L. Two structural isomers that only differ in one of their monodentate ligands have been obtained with the 3-MeOC6H4COO(-) bridges. For all compounds, the Mn(iii) ions display elongated octahedra with a pronounced rhombic distortion...
July 19, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27208569/validation-of-interphase-fluorescence-in-situ-hybridization-ifish-for-multiple-myeloma-using-cd138-positive-cells
#16
Renata Kiyomi Kishimoto, Sarah Lee Vaughan Vulcani de Freitas, Cristina Alonso Ratis, Daniela Borri, Roberta Sitnik, Elvira Deolinda Rodrigues Pereira Velloso
BACKGROUND: Multiple myeloma is a plasma cell neoplasm with acquired genetic abnormalities of clinical and prognostic importance. Multiple myeloma differs from other hematologic malignancies due to a high fraction of low proliferating malignant plasma cells and the paucity of plasma cells in bone marrow aspiration samples, making cytogenetic analysis a challenge. An abnormal karyotype is found in only one-third of patients with multiple myeloma and interphase fluorescence in situ hybridization is the most useful test for studying the chromosomal abnormalities present in almost 90% of cases...
April 2016: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/27079223/antinociceptive-and-anti-inflammatory-effects-of-memora-nodosa-and-allantoin-in-mice
#17
Iziara F Florentino, Daiany P B Silva, Pablinny M Galdino, Roberta C Lino, José L R Martins, Dayane M Silva, José R de Paula, Leonice M F Tresvenzol, Elson A Costa
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves and stems bark of Memora nodosa (Silva Manso) Miers (Bignoniaceae) are used in Brazilian traditional medicine in the treatment of external ulcers and wounds; its roots are used to treat abdominal pain and scabies. AIM OF THE STUDY: Our aim was to evaluate the antinociceptive and anti-inflammatory activities of Memora nodosa roots ethanolic extract (EMN) and allantoin, a secondary metabolite isolated from this plant. MATERIALS AND METHODS: The EMN and allantoin antinociceptive activity were evaluated in mice using both chemical and heat-induced pain models such as acetic acid-induced writhing, formalin and tail-flick tests...
June 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26950035/mrp1-expression-in-ctcs-confers-resistance-to-irinotecan-based-chemotherapy-in-metastatic-colorectal-cancer
#18
Emne Ali Abdallah, Marcello Ferretti Fanelli, Virgílio Souza E Silva, Marcelo Calil Machado Netto, José Luiz Gasparini Junior, Daniel Vilarim Araújo, Luciana Menezes Mendonça Ocea, Marcilei Eliza Cavicchioli Buim, Milena Shizue Tariki, Vanessa da Silva Alves, Victor Piana de Andrade, Aldo Lourenço Abbade Dettino, Celso Abdon Lopes de Mello, Ludmilla Thomé Domingos Chinen
Circulating tumor cells are important markers of tumor progression and can reflect tumor behavior in metastatic colorectal cancer (mCRC). Identification of proteins that confer resistance to treatment is an important step to predict response and better selection of treatment for patients. Multidrug resistance-associated protein 1 (MRP1) and Multidrug resistance-associated protein 4 (MRP4) play a role in irinotecan-resistance, and Excision Repair Cross-Complementation group 1 (ERCC1) expression can confer resistance to platinum compounds...
August 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/26942741/abstracts-20th-annual-congress-of-euroacademia-multidisciplinaria-neurotraumatologica-emn
#19
(no author information available yet)
No abstract text is available yet for this article.
March 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/26842870/the-effect-of-levosulpiride-on-in-vitro-motor-patterns-in-the-human-gastric-fundus-antrum-and-jejunum
#20
D Gallego, O Ortega, C Arenas, I López, E Mans, P Clavé
BACKGROUND: Levosulpiride is a 5HT4 agonist/D2 antagonist prokinetic agent used to improve gastric emptying in patients with functional dyspepsia or gastroparesis. The aim of this study was to characterize its effect on the main in vitro motility patterns in the human fundus, antrum, and jejunum. METHODS: Circular muscle strips from human stomach (antrum and fundus) and jejunum, obtained from 46 patients undergoing bariatric surgery, were studied using organ baths...
June 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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