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https://www.readbyqxmd.com/read/28771934/personalized-medicine-the-potential-yet-realized
#1
John O'Brien
The complex interactions between genes and the environment yield multiple pathophysiologies for the great obstetrical diseases such as preterm birth (Romero R et al, Science, 2014, 345,760-765). Our current, limited capacity to define when and to what extent any number of these pathophysiologies are in effect in individual pregnant patients has resulted in therapeutic strategies being aimed preferentially toward populations defined by risk factors, particularly obstetrical history. However, strategies such as prophylactic progestogen administration indicated for a prior preterm birth necessarily overtreat pregnant women exposing them and their children to potential, possibly unforeseen, harm (O'Brien JM, BJOG 2015;122:610-614)...
August 3, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28727313/insights-from-outside-bjog
#2
Athol Kent, Shona Kirtley
No abstract text is available yet for this article.
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28692181/time-to-test-tamponade
#3
G J Hofmeyr
The general surgical principle of applying direct pressure at the site of haemorrhage has been applied in the treatment of postpartum haemorrhage (PPH) by means of an assortment of inflatable devices introduced into the uterine cavity. Over the last 23 years several reports and reviews in the BJOG and elsewhere have documented the apparent effectiveness of uterine balloon tamponade (UBT) for treatment of PPH. A large study in 2016 reported a success rate after vaginal delivery of 89% (152/171) and concluded that intrauterine balloon tamponade is an effective method for treating severe PPH...
July 10, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28650528/urinary-diversions-in-low-resource-settings
#4
Jeffrey P Wilkinson
Obstetric fistula is a devastating consequence of poorly attended childbirth which occurs almost exclusively in low resource settings. Most women with fistula can be cured or significantly improved by one or more vaginal surgeries. The last resort for women with otherwise incurable obstetric fistula is urinary diversion. The ileal conduit urinary diversion was the procedure considered by the authors of the accompanying article (Walker et al BJOG). Under optimal conditions, any urinary diversion is fraught with numerous potential risks...
June 26, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28632350/insights-from-outside-bjog
#5
Athol Kent, Shona Kirtley
No abstract text is available yet for this article.
July 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28544718/insights-from-outside-bjog
#6
Athol Kent, Shona Kirtley
No abstract text is available yet for this article.
June 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28544220/gdm-shades-of-gray
#7
Robert M Silver
In this issue of BJOG, Kapur and colleagues call for all European women to undergo screening for gestational diabetes (GDM) as recommended by FIGO (Kapur et al., BJOG 2017 XX). They rightly note the adverse fetal, neonatal, and maternal effects of GDM as well as possible downstream implications for the mother and child. Their recommendations echo those of several leading organizations including FIGO. However, despite these recommendations, some European countries, communities, hospitals and clinicians do not screen all women for GDM...
May 24, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28485898/a-call-to-action-for-data-definition-standardization-and-core-outcome-sets
#8
Gary A Dildy
Systematic reviews, which form the pinnacle of the "levels of evidence pyramid", synthesize knowledge and serve to evolve evidence-based medical practice. In this issue of the BJOG, Duffy and colleagues present a systematic review of maternal and offspring outcome reporting across 79 randomized controlled trials (RCT) evaluating 55 various therapeutic interventions for pre-eclampsia. These RCTs reported 119 different outcomes (72 maternal and 47 offspring outcomes) for 31,615 maternal and 28,172 offspring participants...
May 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28481445/optimising-fertility-outcomes-for-women-with-early-stage-cervical-cancer-when-less-is-more
#9
E Tingi, E J Crosbie, G Owens
No abstract text is available yet for this article.
May 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28481444/when-east-meets-west
#10
Qide Han
In the current issue of BJOG, a report titled "Evaluation of HIFU Ablation for Uterine Fibroids: an IDEAL Prospective Exploration Study", was led by Professor Jinghe Lang, a member of Chinese Academy of Technology. While Chinese researchers have been leading the R&D of High-intensity focused ultrasound surgery technology and its clinical applications for more than 20 years, worldwide clinical dissemination has been hindered by the lack of systematic and high quality clinical evaluation. The study by Lang et al...
May 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28467683/clomiphene-citrate-a-reassuringly-safe-drug
#11
Masoud Afnan
In this edition of the BJOG, Weller and colleagues present a population based study in a single centre over 12 years in which 1,872 of 114,961 women took clomiphene, and showed no increase in the rate of overall or specific major malformations. It provides the best available evidence to date that clomiphene (clomifene) citrate is safe. This article is protected by copyright. All rights reserved.
May 3, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28383770/cost-effectiveness-analysis-and-obstetrics-the-time-has-come
#12
Robert M Silver, Brett D Einerson
In this issue of BJOG, ten Eikelder and colleagues report that oral misoprostol and foley bulb catheters for cervical ripening have equal cost-effectiveness. If women receiving foley bulbs undergo ripening at home or on a less intensive unit than a labor and delivery suite, the foley bulb is considerably more cost-effective. They used data from a Dutch RCT, the PROBAAT2 trial, comparing the two methods, which had similar efficacy. The analysis has many strengths including using comparisons from within an RCT, careful assessment of measurable direct hospital costs, and the use of well-chosen sensitivity analyses to evaluate the assumptions under a wide variety of clinical scenarios...
April 6, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28334492/opportunistic-salpingectomy-for-prevention-of-ovarian-cancer
#13
R Manchanda
No abstract text is available yet for this article.
May 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28328055/bjog-referees-2016
#14
(no author information available yet)
No abstract text is available yet for this article.
April 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28322491/threats-to-reliability-risk-erroneous-conclusions-a-survey-of-prospective-registration-and-sample-sizes-of-randomised-trials-in-women-s-health
#15
S K Nijjar, K S Khan
OBJECTIVE: Prospective registration of clinical trials has been required since 2005. We aimed to assess concordance between registered and reported sample sizes among prospectively registered randomised controlled trials (RCTs) in obstetrics and gynaecology. DESIGN: Analysis of prospectively registered and published data. SETTING: Women's health. SAMPLE: Obstetrics and gynaecology RCTs published in eight journals in 2015...
June 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28301716/prenatal-screening-it-is-not-just-about-down-syndrome
#16
M E Norton
No abstract text is available yet for this article.
March 16, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28276189/follicular-flushing-time-to-look-elsewhere-to-improve-ivf-outcomes
#17
Jason M Franasiak
Poor responders represent one of the greatest challenges in assisted reproduction. The very diagnosis threatens the proposed benefit of in vitro fertilization (IVF): attaining a numeric advantage. Thus, it may seem somewhat logical that steps to maximize this numeric advantage may prove beneficial in this population. In this issue of BJOG, Haydardedeoglu et al. assess the benefit of follicular flushing in poor responders undergoing IVF and intracytoplasmic sperm injection (IVF/ICSI) as compared to direct aspiration in a randomized control trial (Haydardedeoglu et al...
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28276149/is-extending-screening-intervals-safe-in-human-papillomavirus-negative-women
#18
H C Kitchener
No abstract text is available yet for this article.
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28224742/insights-from-outside-bjog
#19
Athol Kent, Shona Kirtley
No abstract text is available yet for this article.
March 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28168838/importance-of-including-stillbirth-in-measures-of-preterm-birth
#20
R L Goldenberg, E M McClure
No abstract text is available yet for this article.
February 6, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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