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https://www.readbyqxmd.com/read/29330472/amyloid-deposition-in-a-mouse-model-humanized-at-the-transthyretin-and-retinol-binding-protein-4-loci
#1
Xiangshun Li, Yanyi Lyu, Jingling Shen, Yanshuang Mu, Lixia Qiang, Li Liu, Kimi Araki, Bruno P Imbimbo, Ken-Ichi Yamamura, Shoude Jin, Zhenghua Li
Familial amyloidotic polyneuropathy is an autosomal dominant disorder caused by a point mutation in the transthyretin (TTR) gene. The process of TTR amyloidogenesis begins with rate-limiting dissociation of the TTR tetramer. Thus, the TTR stabilizers, such as Tafamidis and Diflunisal, are now in clinical trials. Mouse models will be useful to testing the efficacy of these drugs. Although several mouse models have been generated, they all express mouse Rbp4. Thus, human TTR associates with mouse RBP4, resulting in different kinetic and thermodynamic stability profiles of TTR tetramers...
January 12, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29329923/different-protein-composition-of-low-calorie-diet-differently-impacts-adipokine-profile-irrespective-of-weight-loss-in-overweight-and-obese-women
#2
R Mateo-Gallego, I Lamiquiz-Moneo, S Perez-Calahorra, V Marco-Benedí, A M Bea, L Baila-Rueda, M Laclaustra, J L Peñalvo, F Civeira, A Cenarro
BACKGROUND AND AIMS: High-protein (HP) diets have shown benefits in cardiometabolic markers such as insulin or triglycerides but the responsible mechanisms are not known. We aimed to assess the effect of three energy-restricted diets with different protein contents (20%, 27%, and 35%; ∼80% coming from animal source) on plasma adipokine concentration and its association with changes in cardiometabolic markers. METHODS: Seventy-six women (BMI 32.8 ± 2.93) were randomized to one of three calorie-reduced diets, with protein, 20%, 27%, or 35%; carbohydrates, 50%, 43%, or 35%; and fat, 30%, for 3 months...
November 4, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29286303/disturbed-vitamin-a-metabolism-in-non-alcoholic-fatty-liver-disease-nafld
#3
REVIEW
Ali Saeed, Robin P F Dullaart, Tim C M A Schreuder, Hans Blokzijl, Klaas Nico Faber
Vitamin A is required for important physiological processes, including embryogenesis, vision, cell proliferation and differentiation, immune regulation, and glucose and lipid metabolism. Many of vitamin A's functions are executed through retinoic acids that activate transcriptional networks controlled by retinoic acid receptors (RARs) and retinoid X receptors (RXRs).The liver plays a central role in vitamin A metabolism: (1) it produces bile supporting efficient intestinal absorption of fat-soluble nutrients like vitamin A; (2) it produces retinol binding protein 4 (RBP4) that distributes vitamin A, as retinol, to peripheral tissues; and (3) it harbors the largest body supply of vitamin A, mostly as retinyl esters, in hepatic stellate cells (HSCs)...
December 29, 2017: Nutrients
https://www.readbyqxmd.com/read/29282297/development-of-multimarker-diagnostic-models-from-metabolomics-analysis-for-gestational-diabetes-mellitus
#4
Wolin Hou, Xiyan Meng, Aihua Zhao, Weijing Zhao, Jiemin Pan, Junling Tang, Yajuan Huang, Huaping Li, Wei Jia, Fang Liu, Weiping Jia
Although metabolomics are desirable to understand the pathophysiology of gestational diabetes mellitus (GDM), comprehensive metabolomic studies of GDM are rare. We aimed to offer a holistic view of metabolites alteration in GDM patients and investigate the possible multimarker models for GDM diagnosis. Biochemical parameters and perinatal data of 131 GDM cases and 138 controls were collected. Fasting serum samples at 75 g oral glucose tolerance test were used for metabolites by ultra performance liquid chromatography-quadrupole-time of flight-mass spectrometry, ultra performance liquid chromatography-triple triple-quadrupole-mass spectrometry and gas chromatography- time-of- flight mass spectrometry platforms...
December 27, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29215751/proteomic-response-of-the-rat-liver-in-differential-swimming-modes
#5
Liang Chen, Yanhua Yang, Yiting Wang, Lipeng Qiu, Hengchuan Xia, Aiai Wang, Hailong Liu, Hongfei Shi, Keping Chen
Moderate exercise helps improve competition results, providing a balanced muscle tone and biochemical activity, whereas excessive training disrupts the balance between training and recovery, causes harm to the organism, and leads to overtraining syndrome (OTS). To explore the mechanisms of different protein expressions during training and acquisition of immunity, we used proteomic analyses to investigate the differences of liver-protein expressions between two swimming modes. Sprague-Dawley rats were randomly divided into control (CT), fatigue training (FT), and exhaustive training (ET) groups, and liver tissues from each group were subjected to two-dimensional electrophoresis (2DE)...
December 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29190912/rbp4-and-thbs2-are-serum-biomarkers-for-diagnosis-of-colorectal-cancer
#6
Weiqiang Fei, Li Chen, Jiaxin Chen, Qinglan Shi, Lumin Zhang, Shuiping Liu, Lingfei Li, Lili Zheng, Xiaotong Hu
The potential role of serum RBP4 and THBS2 as biomarker in colorectal cancer (CRC) diagnosis has never been studied. We investigated in large sample using quantitative ELISA method to explore whether serum RBP4 and THBS2 can act as biomarkers for CRC diagnosis. The concentration of RBP4 and THBS2 was measured in 402 CRC patients' serum samples and 218 normal controls' serum samples. The results showed that the average RBP4 and THBS2 concentrations in normal controls were significantly higher than in CRC patients (36...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29178648/panel-based-whole-exome-sequencing-identifies-novel-mutations-in-microphthalmia-and-anophthalmia-patients-showing-complex-mendelian-inheritance-patterns
#7
Marina Riera, Ana Wert, Isabel Nieto, Esther Pomares
BACKGROUND: Microphthalmia and anophthalmia (MA) are congenital eye abnormalities that show an extremely high clinical and genetic complexity. In this study, we evaluated the implementation of whole exome sequencing (WES) for the genetic analysis of MA patients. This approach was used to investigate three unrelated families in which previous single-gene analyses failed to identify the molecular cause. METHODS: A total of 47 genes previously associated with nonsyndromic MA were included in our panel...
November 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29176573/the-retinol-binding-protein-receptor-2-rbpr2-is-required-for-photoreceptor-outer-segment-morphogenesis-and-visual-function-in-zebrafish
#8
Yi Shi, Elisabeth Obert, Bushra Rahman, Bärbel Rohrer, Glenn P Lobo
Vitamin A (all-trans retinol) plays critical roles in mammalian development and vision. Since vitamin A is food-derived, tissue-specific uptake and storage mechanism are needed. In the eye, uptake of RBP4-retinol is mediated by the receptor Stra6, whereas the receptor mediating RBP4 binding and retinol transport into the liver has just recently been discovered. Here we examined the role of zebrafish retinol binding protein receptor 2 (Rbpr2) for RBP4-retinol uptake in developing embryos, using eye development and vision as sensitive readouts...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150947/levels-of-serum-retinol-binding-protein-4-before-and-after-non-surgical-periodontal-treatment-in-lean-and-obese-subjects-an-interventional-study
#9
Mayte Martínez-Herrera, Francisco Javier Silvestre, Javier Silvestre-Rangil, Sandra López-Domènech, Celia Bañuls, Milagros Rocha
AIM: We aimed to evaluate serum RBP4 levels before and after periodontal therapy in lean and obese subjects with chronic periodontitis (CP) in order to determine its possible association with periodontitis. MATERIALS AND METHODS: This is an interventional study for which a total of 112 lean and 119 obese subjects were recruited. Patients with CP were evaluated before and after three months of non-surgical periodontal treatment. Periodontal, anthropometric, biochemical parameters and serum levels of TNFα, IL-6, hsCRP and RBP4 were assessed...
November 18, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29122953/dietary-weight-loss-induced-changes-in-rbp4-ffa-and-ace-predict-weight-regain-in-people-with-overweight-and-obesity
#10
Roel G Vink, Nadia J Roumans, Edwin C Mariman, Marleen A van Baak
Adipokines and other biomarkers were previously identified with roles in energy expenditure, appetite, satiety, and adiposity. Therefore, we investigated whether dietary weight loss-induced changes in adipokines and other biomarkers known to play a role in weight regulation or energy expenditure could predict weight regain in people with overweight and obesity. In this randomized controlled trial 26 males and 30 females (BMI: 28-35 kg/m(2)) followed either a low-calorie diet (LCD; 1250 kcal/day) for 12 weeks or a very-low-calorie diet (VLCD; 500 kcal/day) for 5 weeks followed by a weight stable period of 4 weeks (dietary intervention (DI) period) and a 9-month follow-up period...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29120147/the-association-between-retinol-binding-protein-4-and-cardiovascular-risk-score-is-mediated-by-waist-circumference-in-overweight-obese-adolescent-girls
#11
Aleksandra Klisić, Nebojša Kavarić, Bojko Bjelaković, Ivan Soldatović, Milica Martinović, Jelena Kotur-Stevuljević
Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Therefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6±1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29114012/cbl-downregulation-increases-rbp4-expression-in-adipocytes-of-female-mice
#12
Gulizar Issa Ameen, Silvia Mora
Obesity leads to adipose tissue dysfunction, insulin resistance and diabetes. Adipose tissue produces adipokines,that contribute to regulate insulin sensitivity. In turn insulin stimulates the production and release of some adipokines. Casitas-b-lymphoma proteins (c-Cbl, Cbl-b and Cbl3) are intracellular adaptor signalling proteins that are rapidly phosphorylated by activation of tyrosine kinase receptors. c-Cbl is rapidly phosphorylated by insulin in adipocytes. Here we tested the hypothesis that Cbl signalling regulates adipokine expression in adipose tissue...
November 7, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29079670/the-levels-of-adipokines-and-hormonal-changes-during-the-menstrual-cycle-in-normal-weight-women
#13
Katarzyna Wyskida, Grzegorz Franik, Tomasz Wikarek, Aleksander Owczarek, Alham Delroba, Jerzy Chudek, Jerzy Sikora, Magdalena Olszanecka-Glinianowicz
CONTEXT: The aim of this study was to assess plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 levels in relation to hormonal changes during the menstrual cycle in young, healthy, normal-weight women. METHODS: The study involved 52 young, healthy, normal-weight women. Anthropometric parameters, body composition and levels of plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 in addition to serum FSH, LH, estradiol, progesterone, 17-OH progesterone, androgens, SHBG and insulin concentrations were measured during a morning in fasting state three times: between days 2-4, days 12-14 and days 24-26 of the menstrual cycle...
October 27, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28964327/performance-of-first-trimester-biochemical-markers-and-mean-arterial-pressure-in-prediction-of-early-onset-pre-eclampsia
#14
Jaana Nevalainen, Teemu Korpimaki, Heikki Kouru, Mikko Sairanen, Markku Ryynanen
OBJECTIVE: To develop a predictive risk model for early-onset pre-eclampsia (EO-PE) using maternal characteristics, combined screening markers, previously reported biomarkers for PE and mean arterial pressure (MAP). METHODS: This retrospective study was conducted at Oulu University hospital between 2006 and 2010. Maternal serum from first trimester combined screening was further analyzed for alpha fetoprotein (AFP), placental growth factor (PlGF), soluble tumor necrosis factor receptor-1 (sTNFR1), retinol binding protein-4 (RBP4), a disintegrin and metalloprotease-12 (ADAM12), soluble P-selectin (sP-selectin), follistatin like-3 (FSTL3), adiponectin, angiopoietin-2 (Ang-2) and sex hormone binding globulin (SHBG)...
October 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28931435/circulating-retinol-binding-protein-4-levels-in-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#15
REVIEW
Zhongwei Zhou, Hongmei Chen, Huixiang Ju, Mingzhong Sun
BACKGROUND: Retinol binding protein 4 (RBP4) is implicated in obesity, insulin resistance and type 2 diabetes mellitus that are closely associated with nonalcoholic fatty liver disease (NAFLD). However, recent investigations regarding circulating RBP4 levels in NAFLD are conflicting. This meta-analysis is to determine whether NAFLD, non-alcoholic steatohepatitis (NASH) and simple steatosis (SS) patients have altered RBP4 levels. METHODS: We performed a systematic search in PubMed, EMBASE and The Cochrane Library up until 18 March 2017, and 12 studies comprising a total of 4247 participants (2271 NAFLD patients and 1976 controls) were included in the meta-analysis...
September 20, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28924174/gene-expression-meta-analysis-in-diffuse-low-grade-glioma-and-the-corresponding-histological-subtypes
#16
Siqi Wang, Feng Jin, Wenliang Fan, Fang Liu, Yan Zou, Xuehan Hu, Haibo Xu, Ping Han
Diffuse low-grade glioma (DLGG) is a well-differentiated, slow-growing tumour with an inherent tendency to progress to high-grade glioma. The potential roles of genetic alterations in DLGG development have not yet been fully delineated. Therefore, the current study performed an integrated gene expression meta-analysis of eight independent, publicly available microarray datasets including 291 DLGGs and 83 non-glioma (NG) samples to identify gene expression signatures associated with DLGG. Using INMEX, 708 differentially expressed genes (DEGs) (385 upregulated and 323 downregulated genes) were identified in DLGG compared to NG...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28895868/identification-of-novel-biomarkers-for-treatment-monitoring-in-canine-leishmaniosis-by-high-resolution-quantitative-proteomic-analysis
#17
Silvia Martinez-Subiela, Anita Horvatic, Damian Escribano, Luis Pardo-Marin, Meric Kocaturk, Vladimir Mrljak, Richard Burchmore, Jose J Ceron, Zeki Yilmaz
The objective of this study was to use the Tandem Mass Tag (TMT) isobaric label-based proteomic approach, in order to identify new potential biomarkers for the treatment monitoring of canine leishmaniosis that could not be identified by the use of gel-based techniques. For this purpose serum samples were obtained from 5 clinically diseased dogs before and one month after the treatment of canine leishmaniosis. The non-depleted serum samples were subjected to reduction, alkylation and trypsin digestion, and the resulting peptides were labeled using 6-plex TMT reagents...
September 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28888344/plasma-retinol-binding-protein-4-levels-and-the-risk-of-ischemic-stroke-among-women
#18
Pamela M Rist, Monik C Jiménez, Shelley S Tworoger, Frank B Hu, JoAnn E Manson, Qi Sun, Kathryn M Rexrode
BACKGROUND: Plasma retinol-binding protein 4 (RBP4) levels have been associated with cardiovascular risk factors and risk of coronary heart disease, but little is known about the association between RBP4 and the risk of ischemic stroke. We hypothesized that elevated RBP4 levels would be associated with an increased risk of ischemic stroke among women. METHODS: We performed a nested case-control study among women enrolled in the Nurses' Health Study who provided blood samples between 1989 and 1990 and were free of prior stroke and cancer...
September 6, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28875223/circulating-adipokines-are-associated-with-pre-eclampsia-in-women-with-type-1-diabetes
#19
Clare B Kelly, Michelle B Hookham, Jeremy Y Yu, Samuel M Lockhart, Mei Du, Alicia J Jenkins, Alison Nankervis, Kristian F Hanssen, Tore Henriksen, Satish K Garg, Samar M Hammad, James A Scardo, Christopher E Aston, Christopher C Patterson, Timothy J Lyons
AIMS/HYPOTHESIS: The incidence of pre-eclampsia, a multisystem disorder of pregnancy, is fourfold higher in type 1 diabetic than non-diabetic women; it is also increased in women with features of the metabolic syndrome and insulin resistance. In a prospective study of pregnant women with type 1 diabetes, we measured plasma levels of adipokines known to be associated with insulin resistance: leptin, fatty acid binding protein 4 (FABP4), adiponectin (total and high molecular weight [HMW]; also known as high molecular mass), retinol binding protein 4 (RBP4) and resistin and evaluated associations with the subsequent development of pre-eclampsia...
December 2017: Diabetologia
https://www.readbyqxmd.com/read/28813718/transgenic-mice-over-expressing-rbp4-have-rbp4-dependent-and-light-independent-retinal-degeneration
#20
Mei Du, Eric Phelps, Michael J Balangue, Aaron Dockins, Gennadiy Moiseyev, Younghwa Shin, Shelley Kane, Laura Otalora, Jian-Xing Ma, Rafal Farjo, Krysten M Farjo
Purpose: Transgenic mice overexpressing serum retinol-binding protein (RBP4-Tg) develop progressive retinal degeneration, characterized by microglia activation, yet the precise mechanisms underlying retinal degeneration are unclear. Previous studies showed RBP4-Tg mice have normal ocular retinoid levels, suggesting that degeneration is independent of the retinoid visual cycle or light exposure. The present study addresses whether retinal degeneration is light-dependent and RBP4-dependent by testing the effects of dark-rearing and pharmacological lowering of serum RBP4 levels, respectively...
August 1, 2017: Investigative Ophthalmology & Visual Science
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