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https://www.readbyqxmd.com/read/28648555/comparison-of-plasma-pigment-epithelium-derived-factor-pedf-retinol-binding-protein-4-rbp-4-chitinase-3-like-protein-1-ykl-40-and-brain-derived-neurotrophic-factor-bdnf-for-the-identification-of-insulin-resistance
#1
F J K Toloza, M C Pérez-Matos, M L Ricardo-Silgado, M C Morales-Álvarez, J O Mantilla-Rivas, J A Pinzón-Cortés, M Pérez-Mayorga, M L Arévalo-García, G Tolosa-González, C O Mendivil
AIMS: To evaluate and compare the association of four potential insulin resistance (IR) biomarkers (pigment-epithelium-derived factor [PEDF], retinol-binding-protein-4 [RBP-4], chitinase-3-like protein 1 [YKL-40] and brain-derived neurotrophic factor [BDNF]) with objective measures of IR. METHODS: We studied 81 subjects with different metabolic profiles. All participants underwent a 5-point OGTT with calculation of multiple IR indexes. A subgroup of 21 participants additionally underwent a hyperinsulinemic-euglycemic clamp...
June 9, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28639612/elevated-serum-retinol-binding-protein-4-levels-are-correlated-with-blood-pressure-in-prehypertensive-chinese
#2
J-X Zhang, G-P Zhu, B-L Zhang, Y-Y Cheng
Retinol-binding protein 4 (RBP4) has been reported involving in the occurrence and development of hypertension. However, to date, few data are available on the correlation between serum RBP4 level and blood pressure (BP) in prehypertension. Therefore, this association was investigated in prehypertensive Chinese. Overall, 160 subjects with prehypertension (Pre-HT group) and 160 subjects with normal BP (NBP group) were recruited in this study. The subjects were divided into the following four subgroups according to body mass index (BMI): obese Pre-HT subgroup; non-obese Pre-HT subgroup; obese NBP subgroup; and non-obese NBP subgroup (n=80 in each)...
June 22, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28625041/energy-regulation-in-newly-diagnosed-tb-with-chronic-energy-deficiency-free-fatty-acids-and-rbp4
#3
Nurpudji A Taslim, Devintha Virani, Ni Ketut Sumartini, Karmila, Agussalim Bukhari, Aminuddin, Suryani As'ad, Raden Satriono, Haerani Rasyid, Irawaty Djaharuddin
BACKGROUND AND OBJECTIVES: Energy metabolism may be dysfunctionally integral between host and infective agent in active tuberculosis, mediated by adipocytokines and free fatty acids (FFA) as the products of triglyceride lipolysis in fat, blood or other tissues. Retinol Binding Protein 4 (RBP4) and asymmetric dimethylarginine (ADMA) are candidate adipocytokines. The possibility of a deleterious metabolic nexus in chronic energy deficiency (CED) (BMI <18.5 kg/m2) is explored. METHODS AND DESIGN: Newly diagnosed patients with tuberculosis (n=63) were selected using consecutive random sampling at a Centre for the Care and Treatment of Lung Diseases in Makassar, Indonesia...
June 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28621339/hepatokines-linking-nonalcoholic-fatty-liver-disease-and-insulin-resistance
#4
REVIEW
Ruth C R Meex, Matthew J Watt
Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which is the most common form of liver disease and is present in up to ∼70% of individuals who are overweight. NAFLD is also associated with hypertriglyceridaemia and low levels of HDL, glucose intolerance, insulin resistance and type 2 diabetes mellitus. Hepatic steatosis is a strong predictor of the development of insulin resistance and often precedes the onset of other known mediators of insulin resistance. This sequence of events suggests that hepatic steatosis has a causal role in the development of insulin resistance in other tissues, such as skeletal muscle...
June 9, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28592664/altered-retinoid-signaling-compromises-decidualization-in-endometriotic-stromal-cells
#5
Mary Ellen Pavone, Saurabh Malpani, Matthew Dyson, Serdar Bulun
Decidualization alters multiple molecular pathways in endometrium to permit successful embryo implantation. We have reported that paracrine factors, including retinoids, secreted from progesterone treated endometrial stromal cells act on nearby epithelial cells to induce the estradiol metabolizing enzyme HSD17B2. This same induction is not seen in endometriotic stromal cells. We have also shown significant differences in retinoid uptake, metabolism and action in endometriotic tissue and stromal cells compared to normal endometrium...
June 7, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28588245/retinol-binding-protein-4-expression-marks-the-short-term-mortality-of-critically-ill-patients-with-underlying-liver-disease-lipid-but-not-glucose-matters
#6
Wei-Ting Chen, Mu-Shien Lee, Chia-Lin Chang, Cheng-Tang Chiu, Ming-Ling Chang
The implications of retinol-binding protein-4 (RBP4) expression in critically ill patients with underlying liver diseases remain unclear. A prospective cohort study involving 200 liver intensive care unit (ICU) patients was conducted, with 274 blood donors as controls. Patient outcomes were assessed using Cox and Kaplan-Meier analyses. Of the 200 ICU patients (mean age: 56.0 yrs), 79.5% were male, 72.5% were cirrhotic, 62% were septic, 29.5% were diabetic, and 29% expired in the ICU (median admission: 7.5 days)...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28559210/cinnamaldehyde-in-diabetes-a-review-of-pharmacology-pharmacokinetics-and-safety
#7
REVIEW
Ruyuan Zhu, Haixia Liu, Chenyue Liu, Lili Wang, Rufeng Ma, Beibei Chen, Lin Li, Jianzhao Niu, Min Fu, Dongwei Zhang, Sihua Gao
Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate its beneficial role in management of diabetes and its complications. This review highlights recent advances of cinnamaldehyde in its glucolipid lowering effects, its pharmacokinetics, and its safety by consulting the Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, National Science and Technology Library, Wanfang Data, and the Web of Science Databases...
May 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28528355/increased-retinol-free-rbp4-contributes-to-insulin-resistance-in-gestational-diabetes-mellitus
#8
Yanmin Chen, Ping Lv, Mengkai Du, Zhaoxia Liang, Menglin Zhou, Danqing Chen
PURPOSE: Retinol-binding protein 4 (RBP4) is a circulating retinol transporter that is strongly associated with insulin resistance. The aim of this study was to evaluate the RBP4 and retinol level in rat model of gestational diabetes mellitus and the relationship between retinol-free RBP4 (apo-RBP4), retinol-bound RBP4 (holo-RBP4) and insulin resistance. METHODS: Pregnant rats were administered streptozotocin to induce diabetes. The RBP4 and retinol levels were evaluated in GDM and normal pregnant rats...
May 20, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28506697/inflammation-and-hemostasis-in-older-octogenarians-implication-in-5-year-survival
#9
Judit Cubedo, Teresa Padró, Francesc Formiga, Assumpta Ferrer, Glòria Padrós, Esther Peña, Lina Badimon
Social changes and medical advances have increased longevity, but the conditions governing healthy vs unhealthy cardiovascular (CV) aging are not fully known. Factors beyond classical CV risk factors may have an important unrecognized value. We sought to identify proteins differentially expressed in healthy octogenarians (HOs) without a history of cardiovascular disease (CVD) and preserved functional and cognitive state compared with octogenarians with a history of CVD and cognitive decline (UHOs) using a systems biology approach, and investigated how these proteins relate to CV mortality at 5-year follow-up...
April 26, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28505082/supervised-clustering-of-adipokines-and-hormonal-receptors-predict-prognosis-in-a-population-of-obese-women-with-type-1-endometrial-cancer
#10
Jennifer Uzan, Enora Laas, Issam Abd Alsamad, Dounia Skalli, Dhouha Mansouri, Bassam Haddad, Cyril Touboul
Obesity is a major risk factor for endometrial cancer (EC). Yet, its impact on prognosis is controversial. Obesity is associated with metabolic and hormonal dysregulation as well as adipokines increase. The aim of this study was to characterize the expression of biological factors related to obesity within the tumor and evaluate their impact on prognosis. One hundred and thirty-six patients, including 55 obese patients, with endometrioid type I EC operated by total hysterectomy were included in this retrospective study conducted in a Tertiary teaching hospital between 2000 and 2013...
May 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28473187/serum-rbp4-and-ckd-association-with-insulin-resistance-and-lipids
#11
Maria Alice M Domingos, Márcia Queiroz, Paulo Andrade Lotufo, Isabela Judith Benseñor, Silvia Maria de Oliveira Titan
OBJECTIVE: Serum RBP4 is new adipokine and it has been related to insulin resistance and diabetes risk in animal and clinical studies. However, there is controversy on this relationship among CKD patients. In this study, we evaluated the association of serum RBP4 with insulin resistance and cardiovascular risk factors in CKD. METHODS: Baseline data from the PROGREDIR Study (Sao Paulo, Brazil) comprising 454 participants (mainly stages 3 and 4) was analyzed. RESULTS: In univariable analysis, RBP4 was inversely related to renal function, age and HDL, and positively related to other lipids, insulinemia, HOMA, glycemia, albumin, phosphorus and right hepatic lobe diameter...
April 18, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28466070/a-cre-mouse-line-for-probing-irradiance-and-direction-encoding-retinal-networks
#12
Shai Sabbah, Daniel Berg, Carin Papendorp, Kevin L Briggman, David M Berson
Cell type-specific Cre driver lines have revolutionized the analysis of retinal cell types and circuits. We show that the transgenic mouse Rbp4-Cre selectively labels several retinal neuronal types relevant to the encoding of absolute light intensity (irradiance) and visual motion. In the ganglion cell layer (GCL), most marked cells are wide-field spiking polyaxonal amacrine cells (ACs) with sustained irradiance-encoding ON responses that persist during chemical synaptic blockade. Their arbors spread about 1 mm across the retina and are restricted to the inner half of the ON sublamina of the inner plexiform layer (IPL)...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28452132/blood-based-protein-biomarkers-for-stroke-differentiation-a-systematic-review
#13
REVIEW
Shubham Misra, Amit Kumar, Pradeep Kumar, Arun K Yadav, Dheeraj Mohania, Awadh K Pandit, Kameshwar Prasad, Deepti Vibha
BACKGROUND: Computed Tomography (CT) scan is the mainstay for diagnosis of stroke; but the facility of CT scan is not easily available. A blood based biomarker approach is required to distinguish ischemic stroke (IS) from hemorrhagic stroke (HS) in pre-hospital settings. OBJECTIVE: To conduct a systematic review of diagnostic utility of blood biomarkers for differential diagnosis of stroke. METHODS: A comprehensive literature search was carried out till March 07, 2017 in PubMed, Cochrane, Medline, OVID, and Google Scholar databases...
April 28, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28448568/inhibitory-effects-of-fenretinide-metabolites-n-4-methoxyphenyl-retinamide-mpr-and-4-oxo-n-4-hydroxyphenyl-retinamide-3-keto-hpr-on-fenretinide-molecular-targets-%C3%AE-carotene-oxygenase-1-stearoyl-coa-desaturase-1-and-dihydroceramide-%C3%AE-4-desaturase-1
#14
Eugenia Poliakov, William Samuel, Todd Duncan, Danielle B Gutierrez, Nathan L Mata, T Michael Redmond
The therapeutic capacity of fenretinide (N-[4-hydroxyphenyl] retinamide; 4-HPR) has been demonstrated for several conditions, including cancer, obesity, diabetes, and ocular disease. Yet, the mechanisms of action for its pleiotropic effects are still undefined. We hypothesized that investigation of two of the major physiological metabolites of fenretinide, N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR), might begin to resolve the multifaceted effects of this synthetic retinoid...
2017: PloS One
https://www.readbyqxmd.com/read/28434357/retinol-binding-protein-4-rbp4-concentration-identifies-v122i-transthyretin-cardiac-amyloidosis
#15
Marios Arvanitis, Steven Simon, Gloria Chan, Denise Fine, Paula Beardsley, Michael LaValley, Daniel Jacobson, Clarissa Koch, John L Berk, Lawreen H Connors, Frederick L Ruberg
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28413425/association-of-retinol-binding-protein-4-with-metabolic-syndrome-in-first-degree-relatives-of-type-2-diabetic-patients
#16
Marjan Tabesh, Atsa Noroozi, Masood Amini, Awat Feizi, Sahar Saraf-Bank, Maryam Zare
BACKGROUND: Retinol-binding protein 4 (RBP4) is known to regulate lipid and glucose metabolism and insulin resistance. The influences of RBP4 on metabolic syndrome (MS) are still unclear. The purpose of this study is to evaluate the association between serum levels of RBP4 and MS components in first-degree relations of type 2 diabetic patients. MATERIALS AND METHODS: This cross-sectional study was performed within the framework of the diabetes prevention project in Isfahan...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28400700/serum-retinol-binding-protein-induced-endothelial-inflammation-is-mediated-through-the-activation-of-toll-like-receptor-4
#17
Mei Du, Ashley Martin, Franklin Hays, Jennifer Johnson, Rafal A Farjo, Krysten M Farjo
PURPOSE: Elevation of serum retinol-binding protein 4 (RBP4) induces inflammation in primary human retinal microvascular endothelial cells (HRECs) via a retinol-independent mechanism; thus, it may play a causative role in the development and progression of vascular lesions in diabetic retinopathy (DR). Since HRECs do not express the classical RBP4 receptor, stimulated by retinoic acid gene 6 (STRA6), this study focuses on identifying the endothelial cell receptor and signaling that mediate RBP4-induced inflammation...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28393633/csp-1103-chf5074-stabilizes-human-transthyretin-in-healthy-human-subjects
#18
Lixia Qiang, Yanxia Guan, Xiangshun Li, Li Liu, Yanshuang Mu, Aki Sugano, Yutaka Takaoka, Toshiyuki Sakaeda, Bruno P Imbimbo, Ken-Ichi Yamamura, Shoude Jin, Zhenghua Li
Hereditary amyloid polyneuropathy is a type of protein misfolding disease. Transthyretin (TTR) is a homotetrameric serum protein and TTR tetramer dissociation is the limiting step in amyloid fibril formation. Thus, prevention of TTR dissociation is a promising therapeutic approach and some TTR stabilizers have been approved for the treatment of TTR amyloidosis. CSP-1103 (CHF5074) is a non-steroidal anti-inflammatory derivative that lacks cyclooxygenase inhibitory activity. In vitro, CSP-1103 stabilizes the TTR tetramer by binding to the thyroxine (T4) binding site...
April 10, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28373218/hepatic-stellate-cells-limit-hepatocellular-carcinoma-progression-through-the-orphan-receptor-endosialin
#19
Carolin Mogler, Courtney König, Matthias Wieland, Anja Runge, Eva Besemfelder, Dorde Komljenovic, Thomas Longerich, Peter Schirmacher, Hellmut G Augustin
Hepatocellular carcinoma (HCC) is among the most common and deadliest cancers worldwide. A major contributor to HCC progression is the cross talk between tumor cells and the surrounding stroma including activated hepatic stellate cells (HSC). Activation of HSC during liver damage leads to upregulation of the orphan receptor endosialin (CD248), which contributes to regulating the balance of liver regeneration and fibrosis. Based on the established role of endosialin in regulating HSC/hepatocyte cross talk, we hypothesized that HSC-expressed endosialin might similarly affect cell proliferation during hepatocarcinogenesis...
June 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28340561/ascorbic-acid-ameliorates-renal-injury-in-a-murine-model-of-contrast-induced-nephropathy
#20
K Rollins, A Noorani, L Janeckova, T Jones, M Griffiths, M P Baker, J R Boyle
BACKGROUND: Contrast induced nephropathy (CIN) is the commonest cause of iatrogenic renal injury and its incidence has increased with the advent of complex endovascular procedures. Evidence suggests that ascorbic acid (AA) has a nephroprotective effect in percutaneous coronary interventions when contrast media are used. A variety of biomarkers (NGAL, NGAL:creatinine, mononuclear cell infiltration, apoptosis and RBP-4) in both the urine and kidney were assayed using a mouse model of CIN in order to determine whether AA can reduce the incidence and/or severity of renal injury...
March 24, 2017: BMC Nephrology
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