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Cerebral oedema

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https://www.readbyqxmd.com/read/28041618/pyogenic-ventriculitis-and-ventricular-empyema-associated-with-staphylococcus-pseudintermedius-in-a-puppy
#1
S A Headley, L G Pretto-Giordano, D F Nóbrega, C S Altrão, L A Villas-Boas, A A Alfieri, A P F R L Bracarense
A 40-day-old male, blue heeler puppy with hindlimb ataxia, nystagmus, apathy, motor incoordination and hyperaesthesia of the forelimbs died 3 days after the onset of clinical signs. Significant gross findings included cerebellar herniation, cerebral oedema and dilation of the third and right lateral cerebral ventricles due to the accumulation of a purulent exudate. Histopathological examination revealed pyogenic ventriculitis and purulent meningoencephalitis. Pure colonies of a coagulase-positive Staphylococcus were isolated from the purulent cerebral exudate...
December 29, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27986927/histological-underpinnings-of-grey-matter-changes-in-fibromyalgia-investigated-using-multimodal-brain-imaging
#2
F B Pomares, T Funck, N A Feier, S Roy, A Daigle-Martel, M Ceko, S Narayanan, D Araujo, A Thiel, N Stikov, M A Fitzcharles, P Schweinhardt
: Chronic pain patients present with cortical grey matter alterations, observed with anatomical magnetic resonance (MR) imaging. Reduced regional grey matter volumes are often interpreted to reflect neurodegeneration but studies investigating the cellular origin of grey matter changes are lacking. We used multi-modal imaging to compare 26 post-menopausal women with 25 healthy controls (age range: 50-75 years) to test whether regional grey matter volume decreases in chronic pain are associated with compromised neuronal integrity...
December 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27974807/long-term-neprilysin-inhibition-implications-for-arnis
#3
REVIEW
Duncan J Campbell
Neprilysin has a major role in both the generation and degradation of bioactive peptides. LCZ696 (valsartan/sacubitril, Entresto), the first of the new ARNI (dual-acting angiotensin-receptor-neprilysin inhibitor) drug class, contains equimolar amounts of valsartan, an angiotensin-receptor blocker, and sacubitril, a prodrug for the neprilysin inhibitor LBQ657. LCZ696 reduced blood pressure more than valsartan alone in patients with hypertension. In the PARADIGM-HF study, LCZ696 was superior to the angiotensin-converting enzyme inhibitor enalapril for the treatment of heart failure with reduced ejection fraction, and LCZ696 was approved by the FDA for this purpose in 2015...
December 15, 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27942481/posterior-reversible-encephalopathy-syndrome-after-intrathecal-methotrexate-infusion-a-case-report-and-literature-update
#4
Efterpi Pavlidou, Evangelos Pavlou, Athanasia Anastasiou, Zoi Pana, Vasiliki Tsotoulidou, Maria Kinali, Emmanuel Hatzipantelis
Posterior reversible encephalopathy syndrome (PRES) is a rare clinical-radiological entity characterised by seizures, severe headache, mental status instability and visual disturbances. Hypertension is typically present. We report a case of a 13-year old boy with Burkitt lymphoma/leukaemia, who presented with posterior leukoencephalopathy 24 hours after intrathecal methotrexate (MTX) infusion. The child presented with headache, seizures, elevated blood pressure and gradual deterioration of his neurological status...
October 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27928693/accumulation-of-lactate-in-the-rat-brain-during-hyperammonaemia-is-not-associated-with-impaired-mitochondrial-respiratory-capacity
#5
Anne Møller Witt, Fin Stolze Larsen, Peter Nissen Bjerring
In acute liver failure (ALF) cerebral oedema and high intracranial pressure (ICP) are potentially deadly complications. Astrocytes cultured in ammonia have shown mitochondrial dysfunction and in rat models of liver failure, de novo lactate production in the brain has been observed and has led to a hypothesis of compromised brain metabolism during ALF. In contrast, normal lactate levels are found in cerebral microdialysate of ALF patients and the oxygen: glucose ratio of cerebral metabolic rates remains normal...
December 7, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27923162/comparison-of-different-osmotic-therapies-in-a-mouse-model-of-traumatic-brain-injury
#6
Vinoth K M Khandelwal, Prabhakar Singh, Tatiana Ravingerova, Marslin Gregory, Hardik Gandhi, Manu Chaudhary
BACKGROUND: Inflammation in the affected region, increased intracranial pressure, consequent oedema and congestion contribute to the negative outcome of traumatic brain injury. Osmotic therapies are recommended for improvement in cognitive and motor functions. Aim of the present study was to evaluate the effect of osmotic therapies in a mice model of traumatic brain injury. METHODS: Experimental closed head injury was performed in adult Swiss albino mice by the weight-drop method...
February 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27888818/high-altitude-illness
#7
Anna Hartman-Ksycińska, Jolanta Kluz-Zawadzka, Bogumił Lewandowski
High-altitude illness is a result of prolonged high-altitude exposure of unacclimatized individuals. The illness is seen in the form of acute mountain sickness (AMS) which if not treated leads to potentially life-threatening high altitude pulmonary oedema and high-altitude cerebral oedema. Medical problems are caused by hypobaric hypoxia stimulating hypoxia-inducible factor (HIF) release. As a result, the central nervous system, circulation and respiratory system function impairment occurs. The most important factor in AMS treatment is acclimatization, withdrawing further ascent and rest or beginning to descent; oxygen supplementation, and pharmacological intervention, and, if available, a portable hyperbaric chamber...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27884858/hemicraniectomy-versus-medical-treatment-with-large-mca-infarct-a-review-and-meta-analysis
#8
Paul Alexander, Diane Heels-Ansdell, Reed Siemieniuk, Neera Bhatnagar, Yaping Chang, Yutong Fei, Yuqing Zhang, Shelley McLeod, Kameshwar Prasad, Gordon Guyatt
OBJECTIVE: Large middle cerebral artery stroke (space-occupying middle-cerebral-artery (MCA) infarction (SO-MCAi)) results in a very high incidence of death and severe disability. Decompressive hemicraniectomy (DHC) for SO-MCAi results in large reductions in mortality; the level of function in the survivors, and implications, remain controversial. To address the controversy, we pooled available randomised controlled trials (RCTs) that examined the impact of DHC on survival and functional ability in patients with large SO-MCAi and cerebral oedema...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27878561/pseudotumoral-brain-lesions-mri-review
#9
Dimitri Renard, Giovanni Castelnovo, Anne Le Floch, Jean-Sebastien Guillamo, Eric Thouvenot
Single or multiple space-occupying lesions on brain MRI, with or without contrast enhancement and/or perilesional oedema, evoke a neoplastic origin. However, a multitude of non-neoplastic disorders can simulate cerebral neoplasia. In this review, we will discuss the MRI characteristics of non-neoplastic disorders that can mimic cerebral neoplasia. Distinguishing MRI characteristics are discussed for each of these non-neoplastic disorders.
November 22, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27873213/is-management-of-hyperglycaemia-in-acute-phase-stroke-still-a-dilemma
#10
REVIEW
C Savopoulos, G Kaiafa, I Kanellos, A Fountouki, D Theofanidis, A I Hatzitolios
INTRODUCTION: Close monitoring of blood glucose levels during the immediate post-acute stroke phase is of great clinical value, as there is evidence that the risk of neurological deterioration is associated with both hyper- and hypoglycaemia. The aim of this review paper is to summarise the evidence on post-stroke blood glucose management and its impact on clinical outcomes, during the early post-acute stage. FINDINGS: Post-stroke hyperglycaemia has been associated with increased cerebral oedema, haemorrhagic transformation, lower likelihood of recanalisation and deteriorating neurological state...
November 21, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27862464/randomized-assessment-of-imatinib-in-patients-with-acute-ischaemic-stroke-treated-with-intravenous-thrombolysis
#11
N Wahlgren, M Thorén, B Höjeberg, T-B Käll, A-C Laska, C Sjöstrand, J Höijer, H Almqvist, S Holmin, A Lilja, L Fredriksson, D Lawrence, U Eriksson, N Ahmed
BACKGROUND: Imatinib, a tyrosine kinase inhibitor, has been shown to restore blood-brain barrier integrity and reduce infarct size, haemorrhagic transformation and cerebral oedema in stroke models treated with tissue plasminogen activator. We evaluated the safety of imatinib, based on clinical and neuroradiological data, and its potential influence on neurological and functional outcomes. METHODS: A phase II randomized trial was performed in patients with acute ischaemic stroke treated with intravenous thrombolysis...
November 14, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27808032/-acute-surgical-treatment-of-malignant-stroke
#12
Alexander Lilja-Cyron, Vagn Eskesen, Klaus Hansen, Daniel Kondziella, Jesper Kelsen
Malignant stroke is an intracranial herniation syndrome caused by cerebral oedema after a large hemispheric or cerebellar stroke. Malignant middle cerebral artery infarction is a devastating disease with a mortality around 80% despite intensive medical treatment. Decompressive craniectomy reduces mortality and improves functional outcome - especially in younger patients (age ≤ 60 years). Decompression of the posterior fossa is a life-saving procedure in patients with malignant cerebellar infarctions and often leads to good neurological outcome...
October 24, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27799499/cervical-artery-dissection-at-high-altitude-an-overview-of-two-patients
#13
Shreeyukta Bhattarai, William Elson, Rashila Pradhan, Prativa Pandey
While altitude illness is common in the Himalayas, conditions unrelated to altitude illness also occur. High altitude cerebral oedema HACE is a global phenomenon of gradual onset affecting both cerebral hemispheres. We outline two cases of cervical artery dissection presenting with sudden onset of focal neurological symptoms at high altitude.
July 2016: Journal of Travel Medicine
https://www.readbyqxmd.com/read/27770771/evaluation-of-efficacy-safety-and-tolerability-of-ambrisentan-in-chinese-adults-with-pulmonary-arterial-hypertension-a-prospective-open-label-cohort-study
#14
Y Huo, Z C Jing, X F Zeng, J M Liu, Z X Yu, G C Zhang, Y Li, Y Wang, Q S Ji, P Zhu, B X Wu, Y Zheng, P P Wang, J Li
BACKGROUND: Although several new drugs have been approved in recent years, pulmonary arterial hypertension (PAH) remains a rapidly progressive disease with a poor prognosis. Ambrisentan, a selective endothelin type A antagonist, has been approved for treatment of PAH. This open label study assessed the efficacy and safety of ambrisentan in Chinese subjects with PAH. METHODS: Eligible patients with PAH (World Health Organisation [WHO] functional class [FC] II orIII) were enrolled and received Ambrisentan (5 mg) once daily for a 12-week preliminary evaluation period, and a 12-week dose-adjustment period (dose titration to 10 mgallowed)...
October 22, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27770229/whole-brain-analysis-of-postmortem-density-changes-of-grey-and-white-matter-on-computed-tomography-by-statistical-parametric-mapping
#15
Yuichi Nishiyama, Hidekazu Kanayama, Hiroshi Mori, Keiji Tada, Yasushi Yamamoto, Takashi Katsube, Haruo Takeshita, Kazunori Kawakami, Hajime Kitagaki
OBJECTIVES: This study examined the usefulness of statistical parametric mapping (SPM) for investigating postmortem changes on brain computed tomography (CT). METHODS: This retrospective study included 128 patients (23 - 100 years old) without cerebral abnormalities who underwent unenhanced brain CT before and after death. The antemortem CT (AMCT) scans and postmortem CT (PMCT) scans were spatially normalized using our original brain CT template, and postmortem changes of CT values (in Hounsfield units; HU) were analysed by the SPM technique...
October 21, 2016: European Radiology
https://www.readbyqxmd.com/read/27733124/hypertonic-saline-alleviates-experimentally-induced-cerebral-oedema-through-suppression-of-vascular-endothelial-growth-factor-and-its-receptor-vegfr2-expression-in-astrocytes
#16
Linqiang Huang, Wei Cao, Yiyu Deng, Gaofeng Zhu, Yongli Han, Hongke Zeng
BACKGROUND: Cerebral oedema is closely related to the permeability of blood-brain barrier, vascular endothelial growth factor (VEGF) and its receptor vascular endothelial growth factor receptor 2 (VEGFR2) all of which are important blood-brain barrier (BBB) permeability regulatory factors. Zonula occludens 1 (ZO-1) and claudin-5 are also the key components of BBB. Hypertonic saline is widely used to alleviate cerebral oedema. This study aimed to explore the possible mechanisms underlying hypertonic saline that ameliorates cerebral oedema effectively...
October 13, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27721832/management-of-severe-rhabdomyolysis-and-exercise-associated-hyponatremia-in-a-female-with-anorexia-nervosa-and-excessive-compulsive-exercising
#17
Marwan El Ghoch, Simona Calugi, Riccardo Dalle Grave
This case report describes the management of a 49-year-old female with restricting-type anorexia nervosa and excessive compulsive exercising associated with rhabdomyolysis, high levels of serum creatine kinase (CK) (3,238 U/L), and marked hyponatremia (Na(+): 123 mEq/L) in the absence of purging behaviours or psychogenic polydipsia; it is the first case report to describe exercise-associated hyponatremia in a patient with anorexia nervosa. The patient, who presented with a body mass index (BMI) of 13.4 kg/m(2), was successfully treated by means of an adapted inpatient version of an enhanced form of cognitive behavioural therapy (CBT-E)...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27696270/new-technologies-new-insights-into-the-pathogenesis-of-hepatic-encephalopathy
#18
Luisa Baker, Bernard Lanz, Fausto Andreola, Javier Ampuero, Anisha Wijeyesekera, Elaine Holmes, Nicolaas Deutz
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which frequently accompanies acute or chronic liver disease. It is characterized by a variety of symptoms of different severity such as cognitive deficits and impaired motor functions. Currently, HE is seen as a consequence of a low grade cerebral oedema associated with the formation of cerebral oxidative stress and deranged cerebral oscillatory networks. However, the pathogenesis of HE is still incompletely understood as liver dysfunction triggers exceptionally complex metabolic derangements in the body which need to be investigated by appropriate technologies...
December 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27695548/a-cost-effectiveness-based-safety-and-efficacy-study-of-resterilized-intra-parenchymal-catheter-based-intracranial-pressure-monitoring-in-developing-world
#19
Deepak Kumar Gupta, Ajay Bisht, Priyam Batra, Purva Mathur, Ashok Kumar Mahapatra
BACKGROUND: The management of traumatic brain injury (TBI) aims to maintain the normal cerebral perfusion in spite of the mass lesions that may occur (haematoma, contusion, and oedema). The monitoring of the intracranial pressure (ICP) is a step in that direction. The intra-parenchymal catheters have the lowest incidence of infection compared to intra-ventricular/subdural catheters with reliable and accurate pressure recordings. The major disadvantage of the intra-parenchymal catheters is the cost, especially in developing nations...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27676780/predictors-of-functional-and-professional-outcomes-in-patients-with-severe-traumatic-brain-injury
#20
Soumaya Boudokhane, Hichem Ben Brahim, Aymen Haj Salah, Houda Migaou, Anis Jellad, Zohra Ben Salah Frih
OBJECTIVE: To determine factors influencing long-term functional and professional outcomes in patients post severe traumatic brain injury (STBI). MATERIAL/PATIENTS AND METHODS: A descriptive analytical transversal and cross-sectional study involving patients with STBI dated more than 1 year and managed in rehabilitation department on an outpatient basis. Described parameters were: coma duration, post-traumatic amnesia duration (PTA), duration of hospitalization in intensive care unit, rehabilitation delay management, brain imaging findings, motor impairment, neuropsychological impairment assessed with Neurobehavioral Rating Scale-Revised (NRS-R), functional outcomes assessed with Functional Independence Measure (FIM) and disability assessed with Glasgow Outcome Scale (GOS)...
September 2016: Annals of Physical and Rehabilitation Medicine
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