J Marc Simard, Bradley Wilhelmy, Natalya Tsymbalyuk, Bosung Shim, Jesse A Stokum, Madison Evans, Anandita Gaur, Cigdem Tosun, Kaspar Keledjian, Prajwal Ciryam, Riccardo Serra, Volodymyr Gerzanich
In human stroke, brain swelling is an important predictor of neurological outcome and mortality, yet treatments to reduce or prevent brain swelling are extremely limited, due in part to an inadequate understanding of mechanisms. In preclinical studies on cerebroprotection in animal models of stroke, historically, the focus has been on reducing infarct size, and in most studies, a reduction in infarct size has been associated with a corresponding reduction in brain swelling. Unfortunately, such findings on brain swelling have little translational value for treating brain swelling in patients with stroke...
February 28, 2024: Brain Sciences