keyword
MENU ▼
Read by QxMD icon Read
search

Complex intervention

keyword
https://www.readbyqxmd.com/read/28938047/diversity-in-the-us-infectious-diseases-workforce-challenges-for-women-and-underrepresented-minorities
#1
Judith A Aberg, Joel Blankson, Jeanne Marrazzo, Adaora A Adimora
Research documents significant gender-based salary inequities among physicians and ongoing inadequacies in recruitment and promotion of physicians from underrepresented minority groups. Given the complexity of the social forces that promote these disparities, their elimination will likely require quantitative and qualitative research to understand the pathways that lead to them and to develop effective solutions. Interventions to combat implicit bias will be required, and structural interventions that hold medical school leadership accountable are needed to achieve and maintain salary equity and racial and gender diversity at all levels...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28938009/altering-neuronal-excitability-to-preserve-network-connectivity-in-a-computational-model-of-alzheimer-s-disease
#2
Willem de Haan, Elisabeth C W van Straaten, Alida A Gouw, Cornelis J Stam
Neuronal hyperactivity and hyperexcitability of the cerebral cortex and hippocampal region is an increasingly observed phenomenon in preclinical Alzheimer's disease (AD). In later stages, oscillatory slowing and loss of functional connectivity are ubiquitous. Recent evidence suggests that neuronal dynamics have a prominent role in AD pathophysiology, making it a potentially interesting therapeutic target. However, although neuronal activity can be manipulated by various (non-)pharmacological means, intervening in a highly integrated system that depends on complex dynamics can produce counterintuitive and adverse effects...
September 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28937984/evidence-of-complex-contagion-of-information-in-social-media-an-experiment-using-twitter-bots
#3
Bjarke Mønsted, Piotr Sapieżyński, Emilio Ferrara, Sune Lehmann
It has recently become possible to study the dynamics of information diffusion in techno-social systems at scale, due to the emergence of online platforms, such as Twitter, with millions of users. One question that systematically recurs is whether information spreads according to simple or complex dynamics: does each exposure to a piece of information have an independent probability of a user adopting it (simple contagion), or does this probability depend instead on the number of sources of exposure, increasing above some threshold (complex contagion)? Most studies to date are observational and, therefore, unable to disentangle the effects of confounding factors such as social reinforcement, homophily, limited attention, or network community structure...
2017: PloS One
https://www.readbyqxmd.com/read/28937980/methanobrevibacter-attenuation-via-probiotic-intervention-reduces-flatulence-in-adult-human-a-non-randomised-paired-design-clinical-trial-of-efficacy
#4
Minseok Seo, Jaeyoung Heo, Joon Yoon, Se-Young Kim, Yoon-Mo Kang, Jihyun Yu, Seoae Cho, Heebal Kim
TRIAL DESIGN: The aim of this study was to investigate which of the gut microbes respond to probiotic intervention, as well as study whether they are associated with gastrointestinal symptoms in a healthy adult human. For the experimental purpose, twenty-one healthy adults were recruited and received probiotic mixture, which is composed of five Lactobacilli strains and two Bifidobacteria strains, once a day for 60 days. Defecation survey and Bioelectrical Impedance Analysis were conducted pre- and post-administration to measure phenotypic differences...
2017: PloS One
https://www.readbyqxmd.com/read/28937952/modeling-the-long-term-consequences-of-repeated-blast-induced-mild-traumatic-brain-injuries
#5
Denes V Agoston
Repeated mild traumatic brain injury (rmTBI) caused by playing collision sports or by exposure to blasts during military operations can lead to late onset, chronic diseases such as chronic traumatic encephalopathy (CTE), a progressive neurodegenerative condition that manifests in increasingly severe neuropsychiatric abnormalities years after the last injury. Currently, because of the heterogeneity of the clinical presentation, confirmation of a CTE diagnosis requires post-mortem examination of the brain. The hallmarks of CTE are abnormal accumulation of phosphorylated tau protein, TDP-43 immunoreactive neuronal cytoplasmic inclusions, and astroglial abnormalities, but the pathomechanism leading to these terminal findings remains unknown...
September 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28937572/obstetric-care-consensus-no-6-periviable-birth
#6
(no author information available yet)
Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937567/obstetric-care-consensus-no-6-summary-periviable-birth
#7
(no author information available yet)
Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937340/research-domain-criteria-as-psychiatric-nosology
#8
Faisal Akram, James Giordano
Diagnostic classification systems in psychiatry have continued to rely on clinical phenomenology, despite limitations inherent in that approach. In view of these limitations and recent progress in neuroscience, the National Institute of Mental Health (NIMH) has initiated the Research Domain Criteria (RDoC) project to develop a more neuroscientifically based system of characterizing and classifying psychiatric disorders. The RDoC initiative aims to transform psychiatry into an integrative science of psychopathology in which mental illnesses will be defined as involving putative dysfunctions in neural nodes and networks...
October 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28937303/palliative-coverage-of-cranial-defect-following-failed-cranial-flap-for-advanced-squamous-cell-carcinoma-case-report
#9
Vyacheslav Makler, Jeffrey S Litt, N Scott Litofsky
INTRODUCTION: With advanced-stage head and neck cancers, patients may develop large and/or complex wounds despite multiple reconstruction attempts. Wound coverage may require novel approaches to palliate the patient. METHOD: We present the case of a 56-year-old female with advanced squamous cell carcinoma of the scalp and skull who required multiple surgical interventions. Despite our best reconstructive efforts, the patient subsequently developed scalp infection and sepsis, necessitating further debridement for source control...
September 22, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28937004/suicide-in-india-part-perceptions-partial-insights-and-inadequate-solutions
#10
K S Jacob
Suicide is a complex phenomenon, often linked to environment. Despite the identification of many social, cultural, economic and political correlates and risk factors, psychiatry continues to argue for curative solutions based on the reductionistic biomedical model, rather than support public health measures to manage the larger sociocultural, economic and political context. While psychiatry and curative medicine help many people, survival of the human body is best explained by the materialist explanation that locates the variation in health and longevity to tangible resources...
May 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28936892/initial-experience-with-cinematic-rendering-for-chest-cardiovascular-imaging
#11
Steven Rowe, Pamela Johnson, Elliot Fishman
Three-dimensional (3D) computed tomography (CT) with volume rendering (VR) and maximum intensity projection (MIP) is an integral component of CT interpretation for diagnosis and treatment planning of vascular pathology. Cinematic rendering (CR is a new rendering algorithm that incorporates a more advanced lighting model than that used for VR, to create photorealistic 3D CT images. The post-processing tool is not yet widely available and its ultimate clinical utility has yet to be assessed in well-designed studies...
September 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936618/defining-and-measuring-diagnostic-uncertainty-in-medicine-a-systematic-review
#12
Viraj Bhise, Suja S Rajan, Dean F Sittig, Robert O Morgan, Pooja Chaudhary, Hardeep Singh
BACKGROUND: Physicians routinely encounter diagnostic uncertainty in practice. Despite its impact on health care utilization, costs and error, measurement of diagnostic uncertainty is poorly understood. We conducted a systematic review to describe how diagnostic uncertainty is defined and measured in medical practice. METHODS: We searched OVID Medline and PsycINFO databases from inception until May 2017 using a combination of keywords and Medical Subject Headings (MeSH)...
September 21, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28936475/surgical-data-science-the-new-knowledge-domain
#13
S Swaroop Vedula, Gregory D Hager
Healthcare in general, and surgery/interventional care in particular, is evolving through rapid advances in technology and increasing complexity of care with the goal of maximizing quality and value of care. While innovations in diagnostic and therapeutic technologies have driven past improvements in quality of surgical care, future transformation in care will be enabled by data. Conventional methodologies, such as registry studies, are limited in their scope for discovery and research, extent and complexity of data, breadth of analytic techniques, and translation or integration of research findings into patient care...
April 2017: Innov Surg Sci
https://www.readbyqxmd.com/read/28936226/challenges-in-modeling-complexity-of-neglected-tropical-diseases-a-review-of-dynamics-of-visceral-leishmaniasis-in-resource-limited-settings
#14
REVIEW
Swati DebRoy, Olivia Prosper, Austin Mishoe, Anuj Mubayi
OBJECTIVES: Neglected tropical diseases (NTD), account for a large proportion of the global disease burden, and their control faces several challenges including diminishing human and financial resources for those distressed from such diseases. Visceral leishmaniasis (VL), the second-largest parasitic killer (after malaria) and an NTD affects poor populations and causes considerable cost to the affected individuals. Mathematical models can serve as a critical and cost-effective tool for understanding VL dynamics, however, complex array of socio-economic factors affecting its dynamics need to be identified and appropriately incorporated within a dynamical modeling framework...
2017: Emerging Themes in Epidemiology
https://www.readbyqxmd.com/read/28935441/hiv-related-self-stigma-and-health-related-quality-of-life-of-people-living-with-hiv-in-finland
#15
Nuno Nobre, Marco Pereira, Risto P Roine, Jussi Sutinen, Harri Sintonen
We examined how HIV-related self-stigma was associated with different domains of quality of life (QoL), as measured by the World Health Organization Quality of Life in HIV-infected persons instrument (WHOQOL-HIV-Bref), and health-related quality of life (HRQoL) as measured by the generic 15D (15-dimensional measure of HRQoL), to identify the factors associated with self-stigma of people living with HIV (PLWH). The study sample included 440 patients living with HIV followed at the Infectious Disease Clinic of Helsinki University Hospital...
September 1, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28935341/conduct-problems-in-youth-and-the-rdoc-approach-a-developmental-evolutionary-based-view
#16
REVIEW
Peter Fonagy, Patrick Luyten
Problems related to aggression in young people are traditionally subsumed under the header of conduct problems, which include conduct disorder and oppositional defiant disorder. Such problems in children and adolescents are an important societal and mental health problem. In this paper we present an evolutionarily informed developmental psychopathology view of conduct problems inspired by the NIMH Research Domain Criteria (RDoC) initiative. We assume that while there are many pathways to conduct problems, chronic or temporary impairments in the domain of social cognition or mentalizing are a common denominator...
September 8, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28934977/er%C3%AE-and-apoe-isoforms-interact-to-regulate-bdnf-5-ht2a-signaling-and-synaptic-function-in-the-female-brain
#17
Anindit Chhibber, Liqin Zhao
BACKGROUND: Depression has been reported to be commonly manifested in patients with Alzheimer's disease (AD) and is considered a risk factor for AD. The human apolipoprotein E (ApoE) gene exists in three major isoforms (coded by ε2, ε3, and ε4), and the ε4 allele has been associated with a greater incidence of both depression and AD. Although mounting evidence points to the potentially complex interaction between these two brain disorders in which ApoE might play a role, the underlying mechanisms are largely unknown...
September 21, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28934928/complexity-of-pathomechanisms-leading-to-diastolic-heart-failure-in-diabetes-mellitus-potential-field-for-therapeutic-interventions
#18
Michael Schwarzer, Michel Noutsias, Frank Spillmann, P Christian Schulze, Torsten Doenst, Carsten Tschöpe
Advanced glycation end products (AGE) have been implicated in diabetes associated complications. They have been suggested as potential mediators in the progression of diabetic heart failure and as a potential target for treatment. Brunvand et al. now provided evidence in that the suggested causal relationship between AGE and diastolic myocardial dysfunction cannot be confirmed in children with type 1 diabetes. The early signs of diastolic myocardial impairment were associated with higher BMI, but not with HbA1c levels...
September 21, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28934137/evidence-for-involvement-of-il-9-and-il-22-in-cows-milk-allergy-in-infants
#19
Karina V Barros, Vera L Flor Silveira, Marisa S Laranjeira, Neusa F Wandalsen, Susana Passeti, Roberta de Oliveira, Regina V Munekata, Paul S Noakes, Elizabeth A Miles, Philip C Calder
Although allergic inflammation is characterized by a T helper (Th) 2-dominant immune response, the discovery of a role for new T cell subsets in inflammatory diseases has added an additional layer of complexity to the understanding of the pathogeneses of allergic diseases. We evaluated plasma cytokine profiles in infants with cows' milk allergy (CMA), who were being treated with an elimination diet. In a prospective, randomized and controlled study, infants (aged 8.4 ± 3.9 months) with CMA were treated with an elimination diet for 120 days, which replaced cows' milk with a hydrolysed soy protein formula (n = 26) or a free amino acid formula (n = 20)...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28932739/agonist-binding-to-chemosensory-receptors-a-systematic-bioinformatics-analysis
#20
Fabrizio Fierro, Eda Suku, Mercedes Alfonso-Prieto, Alejandro Giorgetti, Sven Cichon, Paolo Carloni
Human G-protein coupled receptors (hGPCRs) constitute a large and highly pharmaceutically relevant membrane receptor superfamily. About half of the hGPCRs' family members are chemosensory receptors, involved in bitter taste and olfaction, along with a variety of other physiological processes. Hence these receptors constitute promising targets for pharmaceutical intervention. Molecular modeling has been so far the most important tool to get insights on agonist binding and receptor activation. Here we investigate both aspects by bioinformatics-based predictions across all bitter taste and odorant receptors for which site-directed mutagenesis data are available...
2017: Frontiers in Molecular Biosciences
keyword
keyword
5836
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"