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Surgical pathology

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https://www.readbyqxmd.com/read/29342037/preservation-of-cells-of-the-organ-of-corti-and-innervating-dendritic-processes-following-cochlear-implantation-in-the-human-an-immunohistochemical-study
#1
Takefumi Kamakura, Jennifer T O'Malley, Joseph B Nadol
HYPOTHESIS: This study evaluates the degree of preservation of hair cells, supporting cells, and innervating dendritic processes after cochlear implantation in the human using immunohistochemical methods. BACKGROUND: Surgical insertion of a cochlear implant electrode induces various pathologic changes within the cochlea including insertional trauma, foreign body response, inflammation, fibrosis, and neo-osteogenesis. These changes may result in loss of residual acoustic hearing, adversely affecting the use of hybrid implants, and may result in loss of putative precursor cells, limiting the success of future regenerative protocols...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29341459/multicenter-study-of-diagnostic-procedures-genetic-aberration-analysis-and-first-line-treatment-of-lung-cancer-in-jiangsu-province-china
#2
YangBo Hu, Huan Hu, LiYun Miao, Xin Zhao, Wei Gu, Wei Heng, ZiLi Meng, Jian Feng, Yi You, XingXiang Xu, Rong Hu, HaiQuan Li, Jie Zhao, XiaoLi Zhu, MeiQi Shi, Li Shen, XiuWei Zhang, XiaoWei Yin, Hang Ma, MinHua Shi, Yong Yu, Hong Lv, LiMing Cai, GaoHua Feng, YeQing Zhang, Feng Wu, TangFeng Lv, Yong Song
BACKGROUND: Jiangsu Province, China, is highly developed economically and culturally, and has a high prevalence of lung cancer. We aimed to evaluate the diagnostic procedures, genetic aberration analysis status, and first-line treatment models of lung cancer in Jiangsu Province. METHODS: Lung cancer patients diagnosed in 2016 at 22 tertiary care hospitals were evaluated. Demographic characteristics, tumor histology, staging, family history of lung cancer, auxiliary examinations, genetic testing, and first-line treatment were collected on discharge...
January 17, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29340839/the-cumulative-incidence-and-risk-factors-of-postoperative-inguinal-hernia-in-patients-undergoing-radical-prostatectomy
#3
Ja Yoon Ku, Chan Ho Lee, Won Young Park, Nam Kyung Lee, Seung Hyun Baek, Hong Koo Ha
BACKGROUND: The aim of this study is to investigate the cumulative incidence and risk factors of postoperative inguinal hernia (PIH) in patients undergoing radical prostatectomy, i.e., laparoscopic prostatectomy (LRP) and robot-assisted laparoscopic prostatectomy (RARP). METHODS: This study included 1124 patients who had undergone radical prostatectomy or transurethral resection of bladder tumor from 2011-2016. We compared the cumulative incidence of PIH in the radical prostatectomy groups (460; LRP 341, RARP 119) and the control group (664; transurethral resection of bladder tumor), and we then analyzed the risk factors (age, operative methods, previous abdominal operative history, thickness and width of external oblique muscle and rectus muscle, thickness of abdominal subcutaneous fat layer at Hesselbach's triangle level, body mass index, prostate-specific antigen, operative time, specimen weight, Gleason score, and pathology T-stage) of PIH in the radical prostatectomy groups...
January 16, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29340819/laparoscopic-liver-resection-for-colorectal-liver-metastasis-patients-allows-patients-to-start-adjuvant-chemotherapy-without-delay-a-propensity-score-analysis
#4
Takayuki Kawai, Claire Goumard, Florence Jeune, Eric Savier, Jean-Christophe Vaillant, Olivier Scatton
BACKGROUND: Although adjuvant chemotherapy (AC) is widely used after liver resection (LR) for colorectal liver metastasis (CRLM), surgical invasiveness may lead to delay in starting AC, which is preferably started within 8 weeks postoperative. We investigated whether laparoscopic liver resection (LLR) for CRLM facilitates AC start without delay. METHODS: Between November 2014 and December 2016, 117 consecutive CRLM patients underwent LR followed by AC. LLR and OLR were performed in 30 and 87 patients, respectively...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29340816/expanding-indications-of-robotic-thyroidectomy
#5
Se Hyun Paek, Kyung Ho Kang, Sung Jun Park
BACKGROUND: Robotic thyroidectomy has many advantages with comparable oncologic safety over conventional open surgery in low-risk differentiated thyroid cancer cases. However, there have been few reports on the outcomes of patients who have been treated with robotic thyroidectomy for more advanced thyroid cancer. The aim of this study was to investigate the validity of expanding indications of robotic thyroidectomy for more advanced thyroid cancer. METHODS: The data of 80 patients with thyroid cancer who underwent robotic total thyroidectomy between January 2013 and December 2014 performed by a single surgeon at Chung-Ang University Hospital were retrospectively reviewed...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29340546/pre-and-postoperative-ph-monitoring-and-weight-loss-analysis-in-patients-undergoing-gastric-plication-in-association-with-fundoplication
#6
Flávio Heuta Ivano, Luciana Pereira Mesquita, Cristiane Megumi Simamura, Gustavo Massaki Kuwaki, Julielli Taques Colman, Guilherme Mussi Campos
BACKGROUND: Obese patients with gastroesophageal reflux disease with pathological pH monitoring result may benefit from surgical treatment which is based on the fundoplication technique in association with laparoscopic gastric plication. The Nissen surgery is the gold standard for surgical treatment of gastroesophageal reflux disease, whereas laparoscopic gastric plication is a restrictive surgery that consists of the invagination of the greater curvature, resulting in weight loss. AIM: To compare pre and postoperative pHmetry results and to evaluate weight loss in patients submitted to gastroplasty with fundoplication...
October 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29340518/rankl-expression-predicts-poor-prognosis-in-gastric-cancer-patients-results-from-a-retrospective-and-single-center-analysis
#7
X Zhang, Y Song, N Song, L Zhang, Y Wang, D Li, Z Wang, X Qu, Y Liu
The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immunohistochemical staining. Thirty-eight patients (33%) showed a high level of RANKL expression and 61 patients (53%) showed a high level of RANK expression...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29339639/mri-guided-interstitial-laser-ablation-for-intracranial-lesions-a-large-single-institution-experience-of-133-cases
#8
Ashwin A Kamath, Daniel D Friedman, Carl D Hacker, Matthew D Smyth, David D Limbrick, Albert H Kim, Ammar H Hawasli, Eric C Leuthardt
BACKGROUND: Managing difficult-to-access lesions or surgically accessible lesions in fragile patients is a central problem in neurosurgery. MRI-guided interstitial laser ablation (ILA) is a minimally invasive option that may provide a safe means of treating these challenging patients. OBJECTIVE: We aim to (1) evaluate safety, efficacy, and preliminary outcomes within a diverse and large series of ILA treatments; and (2) report technical details and operative trends that proved useful over time in the authors' experience and that may be of use to neurosurgeons who perform ILA...
January 17, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29338280/variable-skeletal-anatomical-features-of-acromegaly-in-the-skull-and-craniocervical-junction
#9
Maria Piagkou, Othon Manolakos, Theodore Troupis, Nikolaos Lazaridis, Konstantinos Laios, Alexandros Samolis, Konstantinos Natsis
OBJECTIVE: This study adds important information regarding the morphological alterations caused by growth hormone hypersecretion in the skull and craniocervical junction (CCJ). A variably asymmetric skull due to acromegaly coexists with expansion of the paranasal sinuses and multiple Wormian bones. CASE REPORT: A pathologically asymmetric dry skull of a European male, aged 38 years at death, with cranial vault and skull base thickening is described. The extensive paranasal sinus pneumatization caused a generalized thinning of the bony walls...
November 2017: Acta Medica Academica
https://www.readbyqxmd.com/read/29337932/high-number-of-circulating-tumor-cells-predicts-poor-survival-of-cutaneous-melanoma-patients-in-china
#10
Jisen Li, Wenhua Fu, Wei Zhang, Peng Li
BACKGROUND Melanoma is an aggressive cancer with complex etiology and poor prognosis. Surgical resection is still the primary treatment of melanoma, but shows limited efficacy in late-stage patients. Additionally, reliable prognostic markers of skin melanoma patients are still lacking. Circulating tumor cells (CTCs) have shown promise in predicting prognosis of multiple cancers. Evaluating the prognostic value of CTC number in melanoma patients. MATERIAL AND METHODS CTCs were isolated by immunomagnetic capture from 7...
January 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29337773/prognostic-factors-for-locoregional-recurrence-in-neuroendocrine-tumors-of-the-rectum
#11
Erica S Tsang, Yarrow J McConnell, David F Schaeffer, Yaling Yin, Caroline H Speers, Hagen F Kennecke
BACKGROUND: Optimal management of rectal neuroendocrine tumors is not yet well defined. Various pathologic factors, particularly tumor size, have been proposed as prognostic markers. OBJECTIVE: We characterized sequential patients diagnosed with rectal neuroendocrine tumors in a population-based setting to determine whether tumor size and other pathologic markers could be useful in guiding locoregional management. DESIGN: This study is a retrospective analysis of data from the British Columbia provincial cancer registry...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29337716/management-of-biceps-tendon-pathology-from-the-glenoid-to-the-radial-tuberosity
#12
Rachel M Frank, Eric J Cotter, Eric J Strauss, Laith M Jazrawi, Anthony A Romeo
Management of proximal and distal biceps tendon pathology is evolving. The long head of the biceps tendon, if inflamed, may be a pain-producing structure. In appropriately indicated patients, a symptomatic long head of the biceps tendon can be surgically managed via tenotomy, tenodesis, and/or superior labrum anterior to posterior repair. In some patients, primary superior labrum anterior to posterior pathology can be managed via biceps tenodesis. Determining which procedure is most appropriate and which technique and implant are preferred for a given patient with biceps tendon pathology is controversial...
January 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29337642/perineural-invasion-in-parotid-gland-malignancies
#13
Phillip Huyett, Umamaheswar Duvvuri, Robert L Ferris, Jonas T Johnson, Barry M Schaitkin, Seungwon Kim
Objectives To investigate the clinical predictors and survival implications of perineural invasion (PNI) in parotid gland malignancies. Study Design Case series with chart review. Setting Tertiary care medical center. Subjects and Methods Patients with parotid gland malignancies treated surgically from 2000 to 2015 were retrospectively identified in the Head and Neck Cancer Registry at a single institution. Data points were extracted from the medical record and original pathology reports. Results In total, 186 patients with parotid gland malignancies were identified with a mean follow-up of 5...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29336979/prostate-magnetic-resonance-imaging-the-truth-lies-in-the-eye-of-the-beholder
#14
Joseph C Riney, Nabeel E Sarwani, Shehzad Siddique, Jay D Raman
PURPOSE: To determine the diagnostic accuracy and interobserver variability of radiologic interpretation of magnetic resonance imaging (MRI) performed for surgical planning before prostatectomy. PATIENTS AND METHODS: The records of 233 men undergoing prostatectomy with presurgical multiparametric 3T surface body coil MRI were reviewed. All initial films were read by a fellowship-trained body radiologist provided with relevant clinical information. A senior radiologist then reread all pelvic MRIs blinded to the initial interpretation with findings from both readings compared to final pathology...
January 11, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29336340/-training-program-on-medical-urology-future-perspectives
#15
Javier Gil Moradillo, Fernando Cabrera Meiras, Manuel Alonso Isa, Alba Lara Isla, Juan Justo Quintas, Esther García Rojo, Daniel González Padilla, Borja García Gómez, José Medina Polo, Javier Romero Otero
Urology is defined as the medical-surgical specialty that includes the study, diagnosis and treatment of medical conditions of the urinary system. It is well specified by the National Commission of Specialties that we must know the medical pathology that concerns us. However, on occasions, resident training focuses on the surgical field and oncological pathology, which, although one of the main pillars of the specialty, is usually to the detriment of training in medical and functional pathology. We conducted a survey of residents in the fourth year of Urology in Spain, where we asked about the quality of training in Andrology and Functional Urology...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29336336/-training-program-in-urological-laparoscopic-surgery-future-perspective
#16
Alfredo Aguilera Bazán, Juan Gómez Rivas, Estefanía Linares-Espinós, Mario Alvarez-Maestro, Luis Martínez-Piñeiro
Nowadays in urology, laparoscopic surgery is a reality that implies a very high percentage of the daily surgical activity. The interest in laparoscopy in urological pathology is undeniable, and the advantages for our patients with this approach are clear in most cases. But how do we deal with learning curve of this technique? What is the difficulty in laparoscopy training? What future perspectives might offer this approach? Difficulties in learning laparoscopy are easily identified and clear. The loss of the image in 3 dimensions, loss of touch, great dependence on surgical instruments, among others...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29336299/-duplication-cyst-as-cause-of-ileus-in-a-16-year-old-girl
#17
Anastasia S Buch, Rie Adser Virkus
A 16-year-old girl was admitted to hospital with lower abdominal pain. An ultrasound examination suggested an ovarian cyst. A laparoscopic procedure found that a duplication cyst in the patient's ileum had caused mechanical ileus. The cyst was surgically resected through the creation of an end-to-end anastomosis, and pathological examination confirmed it to be a duplication cyst. Duplication cysts are a rare congenital disorder, especially past infancy. They are characterized by an epithelium of gastrointestinal origin and a lining of smooth muscle in their walls...
January 15, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29336292/use-of-intraoperative-negative-margins-reduces-inverted-papilloma-recurrence
#18
Amar Miglani, Joseph M Hoxworth, Matthew A Zarka, Devyani Lal
BACKGROUND: Recurrence of inverted papilloma (IP) is a problem in 12-17% of tumors. Controversy exists regarding benefits of intraoperative frozen section histopathology (IFSH) for IP resection; however, to our knowledge, no study has specifically investigated this. IFSH for IP resection is the standard of care in our practice. We, therefore, reviewed our outcomes of using IFSH for IP resection. A secondary goal was to assess the reliability of IFSH. METHODS: Patients with IP who underwent surgical resection (2010-2016) with minimum 9-month follow-up were included...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29336291/extent-of-surgery-in-endoscopic-transsphenoidal-skull-base-approaches-and-the-effects-on-sinonasal-morbidity
#19
Vincent Wu, Michael D Cusimano, John M Lee
BACKGROUND: Endoscopic transsphenoidal skull base surgery (ETSS) is now considered the criterion standard approach for resection of pituitary adenomas and other midline anterior skull base lesions. Normal sinonasal structures are resected during ETSS, which raises concerns for nasal morbidity and patient-based outcome. OBJECTIVE: To perform a surgical outcome assessment by examining whether the extent of ETSS approaches affected patient-specific sinonasal quality of life as measured by the 22-item Sino-Nasal Outcome Test (SNOT-22)...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29335017/effect-of-laparoscopy-by-single-port-endoscopic-access-in-benign-adnexal-surgery-study-protocol-for-a-randomized-controlled-trial
#20
Andy Schmitt, Patrice Crochet, Karine Baumstark, Claire Tourette, Sabine Poizac, Audrey Pivano, Léon Boubli, Ludovic Cravello, Aubert Agostini
BACKGROUND: Laparoscopic surgery has become the preferred surgical approach due to a reduction in postoperative pain, better recovery, shorter hospitalization, and improved esthetic outcomes. Laparoscopic surgery with single-port laparoscopy (SPL) is a laparoscopic surgery technique that is based on making a single parietal incision using a single trocar specifically designed to allow introduction of several instruments. The level of evidence regarding the advantages of SPL in terms of postoperative pain has remained low despite several randomized studies...
January 15, 2018: Trials
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