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Surgical pathology

G Li, Q Luo, Z Lang, Y Li, A Wang, K Wang, Y Niu
OBJECTIVE: To evaluate the pathological features and define the optimal surgical margins (SM) of nephron-sparing surgery (NSS) for kidney neoplasms 4-7 cm (stage pT1b) on preoperative imaging. MATERIALS AND METHODS: The retrospective study included 748 patients who were diagnosed stage pT1b renal tumors and underwent either radical nephrectomy (RN, n = 475) or NSS (n = 273) from January 2004 to March 2017. The tumor size, pathological subtype, Fuhrman grade, status of peritumoral pseudocapsule (PC) and tumor multifocality were recorded...
March 21, 2018: Clinical & Translational Oncology
Yu Ohkura, Junichi Shindoh, Masaki Ueno, Toshiro Iizuka, Harushi Udagawa
BACKGROUND: Treatment for patients who have achieved clinical complete response (cCR) after neoadjuvant therapy has not been established, and there is no consensus regarding the indications for either esophagectomy or nonsurgical treatment. METHODS: Among 1,545 patients with esophageal cancer at Toranomon Hospital between January 2006 and August 2017, 39 who achieved cCR after neoadjuvant treatment were divided into two groups according to treatment: esophagectomy group (n = 18) and nonsurgical treatment group (n = 21) for comparison...
March 21, 2018: Annals of Surgical Oncology
Hyun Jung Koo, Joon-Won Kang, Jeong A Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee, Tae-Hwan Lim, Dong Hyun Yang
In patients with aortic regurgitation (AR), a precise preoperative assessment of aortic valve (AV) pathology is important if AV repair or sparing operation is an alternative option. The aim of this study was to assess the diagnostic accuracy of computed tomography (CT) for evaluating the AR mechanism compared with surgical inspection. 59 patients with AR who underwent AV surgery and preoperative cardiac CT were evaluated. AR mechanism was classified into type 1 (aortic dilatation or cusp perforation), type 2 (prolapsed cusp) and type 3 (cusp retraction)...
March 21, 2018: International Journal of Cardiovascular Imaging
Alanna Van Hooser, Todd R Williams, Daniel T Myers
Mucinous appendiceal neoplasms are uncommon, but important to recognize with imaging due to malignant potential. Peritoneal seeding and pseudomyxoma peritonei can occur with both frankly malignant as well as low-grade appendiceal neoplasms. Prospective imaging identification of potential appendiceal neoplasm is paramount to clinical/surgical management. When a mucinous appendiceal neoplasm is suspected, a right hemicolectomy with lymph node dissection is the preferred surgical management. Unfortunately, accurate preoperative diagnosis can be challenging due to a wide range of clinical presentations and overlapping imaging appearances of appendiceal neoplasms with benign entities...
March 21, 2018: Abdominal Radiology
Mustafa Zakkar, Vito Domanico Bruno, Alexandru Ciprian Visan, Stephanie Curtis, Gianni Angelini, Emmanuel Lansac, Serban Stoica
Aortic valve replacement is the gold standard for the management of patients with severe aortic stenosis or mixed pathology that is not amenable to repair according to currently available guidelines. Such a simplified approach may be suitable for many patients, but it is far from ideal for young adults considering emerging evidence demonstrating that conventional valve replacement in this cohort of patients is associated with inferior long-term survival when compared to the general population. Moreover; the utilisation of mechanical and bioprosthetic valves can significantly impact on quality and is linked to increased rates of morbidities...
2018: Frontiers in Surgery
Matthias Waldner, Holger J Klein, Walter Künzi, Merlin Guggenheim, Jan A Plock, Pietro Giovanoli
Objectives: Patients undergoing reduction mammoplasty (RM) bear the risk of having occult breast cancer nests. The detection rate of malignant neoplasms in the resected specimens, varies greatly in the literature. The aim of our present study was to analyze risk factors and evaluate histopathological findings in our cohort of patients who underwent RM towards our center. Material and methods: In this retrospective single center study we analyzed 559 female patients [median age 35...
2018: Frontiers in Surgery
Guilherme Naccache Namur, Anna Carolina Batista Dantas, Ricardo Jureidini, Thiago Costa Ribeiro, Ulysses Ribeiro Junior, Estela Figueira, Ivan Cecconello, Telesforo Bacchella
Background: Due to rising life expectancy of population, very complex surgical procedures such as pancreaticoduodenectomy (PD), are more commonly being performed in elderly patients. The objective of this study was to evaluate the safety of PD in patients older than 75 years old and the risk factors associated with severe complications. Methods: Patients who underwent PD for periampullary tumors were retrospectively reviewed and divided into two groups, A (<75 years) and B (>75 years)...
February 2018: Journal of Gastrointestinal Oncology
Sang Jun Song, Cheol Hee Park, Hu Liang, Sang Jun Kim
Noise in the knee joint is a common symptom that often leads to outpatient clinic visits. However, there have been no previous review articles regarding noise around the knee despite its high prevalence. We will review the noise characteristics according to sound nature and onset as well as factors for differentiation between physiological and pathological noises. In addition, we will describe causes of the physiological and pathological noises and management of noise in the knee. An appropriate review of the characteristics of noise, its pathophysiology, and factors for differentiation between physiological and pathological noises can facilitate patient guidance...
March 2018: Clinics in Orthopedic Surgery
Dezhi Li, Yu Zhou, Yanhui Liu, Ye Lin, Min Yu, Xin Lu, Bowen Huang, Zhonghai Sun, Zhixiang Jian, Baohua Hou
Background: Liver kinase B1 (LKB1) is a key regulatory protein of cellular metabolism, proliferation, and polarity. The present study aimed to characterize the expression pattern of LKB1 in pancreatic neuroendocrine tumors (pNETs) and evaluate the relationship between LKB1 expression and prognosis in pNETs. Patients and methods: We retrospectively analyzed the pathologic and clinical data of 71 pNET patients who underwent curative surgical resection in Guangdong General Hospital...
2018: OncoTargets and Therapy
H Nagaraja, N Srivatsa, S Hemalatha, S Shweta, S K Raghunath
Although lymphadenectomy is currently accepted as most accurate and reliable staging procedure for lymph node metastases, its therapeutic benefit in renal cell carcinoma (RCC) still remains controversial. Although the new, targeted therapy paradigms have changed the treatment of patients with advanced RCC and offer prolonged survival, cure is extremely uncommon in the absence of surgical resections. In this paper, the current role of metastasectomy is reviewed. Review the available literature concerning the role of retroperitoneal lymph node dissection and metastasectomy in outcome of oligometastatic RCC...
March 2018: Indian Journal of Surgical Oncology
Elizabeth Mathew Iype, Santhosh Kumar N, Sreekanth S Kumar, Bipin T Varghese, Jaya C Jose
To study the clinicopathological and molecular factors which correlate with nodal metastasis in laryngeal and hypopharyngeal carcinoma, a retrospective analysis of 170 patients who underwent surgery for laryngeal and hypopharyngeal carcinoma at RCC, Trivandrum from 2006 to 2010 was done. The pathological nodal stage and levels of involvement were correlated with the clinicopathologic features of the primary disease. Neck node positivity was significantly more for lesions of pyriform sinus lesion (61%), with thyroid cartilage erosion (56%) and with base tongue involvement (88%)...
March 2018: Indian Journal of Surgical Oncology
Nootan Kumar Shukla, S V Suryanarayana Deo, Pankaj Kumar Garg, N M L Manjunath, Suman Bhaskar, V Sreenivas
The aim of the present study was to provide insight into various demographic, clinical, and management profile of Indian patients with oral tongue squamous cell cancer (OTSCC). All the OTSCC patients who had undergone surgical treatment during 1995 to 2010 at a tertiary care center in North India were considered for the present study. The details of the patients were retrieved from a prospectively maintained computerized database. A total of 124 patients were included in the present study. Mean age of the patients was 50...
March 2018: Indian Journal of Surgical Oncology
Svitlana Veniaminivna Kolomiiets, Kristina Oleksandrivna Udaltsova, Tetiana Andriivna Khmil, Alina Mykolaiivna Yelinska, Olena Anatoliivna Pisarenko, Viktoriya Ihorivna Shynkevych
Sialolithiasis is one of the most common and extensively obstructive disorders of the major salivary glands. Here, we report 3 cases of sialolithiasis in the submandibular salivary gland showing symptomatic similarities to other dental and non-dental disorders of the maxillofacial area. How the various clinical features of this condition and findings on 3D-CT may lead to a misdiagnosis are also discussed. In the first case, that of a 45-year-old woman, a final diagnosis of a non-radiopaque submandibular sialolith allowed the initially indicated surgical extraction of a malerupted and semi-impacted right mandibular 3rd molar to be abandoned...
2018: Bulletin of Tokyo Dental College
L Lu, H Z Shi, Z J Xiao, D Wang, C L Li
Objective: To summarize the experience in diagnosis and treatment of primary retroperitoneal liposarcoma. Methods: The clinic data of 73 cases of primary retroperitoneal liposarcoma were reviewed. The age of patients was 23 to 75 years old, with a median age of 53 years. Forty-five cases were treated for the first time, and 28 cases were re-treated after local recurrence. All patients underwent ultrasonography, CT or MRI before operation and were diagnosed of primary retroperitoneal liposarcoma. Results: No lymph node and distant metastasis were found in all patients...
March 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
H T Gu, J Y Zhou, T Wu, J Y Zhou
Objective: To investigate the clinical features and prognosis of patients with pulmonary sarcomatoid carcinoma (PSC). Methods: The study retrospectively reviewed the clinical, radiological, pathological characteristics and prognosis of 76 patients with PSC who were treated in the First Affiliated Hospital of Medical School of Zhejiang University from January 2011 to December 2016. Gender, age, smoking history, tumor location, tumor size, lymph node metastasis, distant metastasis, TNM staging and treatment methods were analyzed to determine the factors affecting the prognosis of PSC patients...
March 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Deng Xiang, Jiannan He, Zimeng Fan, Fangfang Xiong, Gang Liu, Sufen Chen, Wu Wen, Jianfeng Li, Junhua Ai, Renhua Wan, Gongxian Wang, Jun Shi
RATIONALE: Situs inversus totalis (SIT) is a rare anatomical variation of the internal organs, and solid pseudopapillary tumor of the pancreas (SPTP) is a rare tissue type of pancreatic tumors, classified as benign or low-grade malignancy. However, to our knowledge, a patient with SIT and SPTP is extremely rare and has never been reported. PATIENT CONCERNS: We retrospectively analyzed a case of SIT with SPTP in a 45-year-old woman. The main complaints were abdominal pain and sensation of heaviness for 2 weeks...
March 2018: Medicine (Baltimore)
Z X Ren, C L Liu, Q Zhang, F Xu, Y N Zheng, X J Li, J Yang
RATIONALE: Necrotizing fasciitis (NF) is a life-threatening situation that is rare in children, especially infants, and early diagnosis is challenging. Timely identification and broad-spectrum antibiotic and supportive treatment before surgical debridement are very important for survival and may reduce scar formation. PATIENT CONCERNS: A previously healthy 4-month-old infant was admitted to our pediatric intensive care unit (PICU) with a history of fever and cough for 5 days and extreme swelling of the scrotum for one day...
March 2018: Medicine (Baltimore)
Bo Ma, Yingjun Zhu, Yixin Liu
Atypical polypoid adenomyoma (APA) is a rare uterine lesion, which has a high rate of recurrence and malignant transformation. How to treat this disease is crucial for the prognosis, but there are few reports on it.We retrospectively reviewed the clinical records of all the patients diagnosed with APA after surgical therapy in our hospital. All the clinical information, pathological results, treatment, and outcome were retrieved from the clinical records.A total of 43 patients were diagnosed with APA. The median age was 56...
March 2018: Medicine (Baltimore)
Rym El Khoury, Christopher Kabir, Vijay K Maker, Mihaela Banulescu, Margaret Wasserman, Ajay V Maker
BACKGROUND: A subset of intraductal papillary mucinous neoplasms (IPMNs) will progress to invasive adenocarcinoma, however identifying invasive from non-invasive disease preoperatively remains challenging. The rate of malignancy in resected IPMNs in the US remains unclear. OBJECTIVE: We aimed to determine the rate of malignancy and factors associated with high-risk pathology in resected IPMNs. METHODS: The most recent annual cohort of patients undergoing pancreatectomy included in the American College of Surgeons National Surgical Quality Improvement Program were assessed, and contributions of demographics, preoperative laboratory values, and outcome data to level of IPMN dysplasia were analyzed...
March 20, 2018: Annals of Surgical Oncology
Bin Sato, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Naoki Iwata, Norifumi Hattori, Masaya Suenaga, Masamichi Hayashi, Suguru Yamada, Kenta Murotani, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND: Surgical resection is the mainstay of treatment for patients with gastric cancer (GC). Development of a simple, high-performance, integrated scoring system is needed to provide appropriate management. This study aimed to evaluate predictive values of the systemic inflammation score (SIS) for short- and long-term outcomes of patients who underwent surgery for GC. METHODS: A total of 187 patients who underwent gastrectomy for pT2-4 GC without preoperative treatment were analyzed...
March 20, 2018: World Journal of Surgery
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