keyword
https://read.qxmd.com/read/38448654/long-non-coding-rna-ccat1-acts-as-an-oncogene-to-promote-radiation-resistance-in-lung-adenocarcinoma-an-epigenomics-based-investigation
#21
JOURNAL ARTICLE
Jian Li, Shengnan Guo, Tianhao Li, Songliu Hu, Jianyu Xu, Xiangying Xu
Long non-coding RNAs (lncRNAs) appear to be the crucial modulators in various processes and critically influence the oncogenesis. As one of the LncRNAs, LncRNA CCAT1 has been reported to be closely associated with the progression multiple cancers, but its role in modulating the radioresistance of lung adenocarcinoma (LUAD) remains unclear. In our present study, we screened the potential radioresistance related LncRNAs in LUAD based on the data from The Cancer Genome Atlas (TCGA) database. Data suggested that CCAT1 was abundantly expressed in LUAD and CCAT1 was significantly associated with poor prognosis and radioresistance...
March 7, 2024: Functional & Integrative Genomics
https://read.qxmd.com/read/38445632/understanding-the-molecular-mechanism-responsible-for-developing-therapeutic-radiation-induced-radioresistance-of-rectal-cancer-and-improving-the-clinical-outcomes-of-radiotherapy-a-review
#22
REVIEW
Samatha M Jain, Shruthi Nagainallur Ravichandran, Makalakshmi Murali Kumar, Antara Banerjee, Alexander Sun-Zhang, Hong Zhang, Rupak Pathak, Xiao-Feng Sun, Surajit Pathak
Rectal cancer accounts for the second highest cancer-related mortality, which is predominant in Western civilizations. The treatment for rectal cancers includes surgery, radiotherapy, chemotherapy, and immunotherapy. Radiotherapy, specifically external beam radiation therapy, is the most common way to treat rectal cancer because radiation not only limits cancer progression but also significantly reduces the risk of local recurrence. However, therapeutic radiation-induced radioresistance to rectal cancer cells and toxicity to normal tissues are major drawbacks...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38440485/extraskeletal-myxoid-chondrosarcoma-of-floor-of-mouth-a-rare-case-report-and-review-of-literature
#23
JOURNAL ARTICLE
Surendra K Dabas, Nandini N Menon, Reetesh Ranjan, Bikas Gurung, Sukirti Tiwari, Bharat Bhushan Bassan, Himanshu Shukla, Sunil Pasricha, Ajit Sinha, Rahul Kapoor, Vinay Kumar Verma, Devesh Verma, Saurabh Arora, Ashwani Sharma, Sourabh Mukharjee, Rishu Singal, Trishala Bhadauria Fernandes
INTRODUCTION: Chondrosarcomas are rare malignancies of the cartilage and myxoid chondrosarcoma is its variant which commonly occurs in soft tissue of extremities. Extraskeletal chondrosarcoma is a rare malignant neoplasm of bone or soft tissue origin and is characterized by the presence of spindle cells admixed with well differentiated cartilage or chondroid stroma. They are mostly radioresistant tumours and surgical resections with adequate margins is considered as the ideal treatment modality with adjuvant radiotherapy in high grade tumours and add on chemotherapy, in case of presence of poor prognostic factors...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38432778/persons-chronically-exposed-to-low-doses-of-ionizing-radiation-a-cytogenetic-dosimetry-study
#24
JOURNAL ARTICLE
Oksana Cherednichenko, Anastassiya Pilyugina, Serikbai Nuraliev, Dinara Azizbekova
The dosimetry and control of exposure for individuals chronically exposed to ionizing radiation are important and complex issues. Assessment may be optimized by evaluating individual adaptation and radiosensitivity, but it is not possible for a single model to account for all relevant parameters. Our goal was to develop approaches for the calculation of doses for persons chronically exposed to ionizing radiation, taking their radiosensitivities into consideration. On the basis of ex vivo radiation of blood samples, dose-effect models were constructed for dose ranges 0...
2024: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://read.qxmd.com/read/38424169/two-distinct-subpopulations-of-marginal-zone-b-cells-exhibit-differential-antibody-producing-capacities-and-radioresistance
#25
JOURNAL ARTICLE
Sujin Lee, Yeunjung Ko, Hyun Woo Lee, Won Joon Oh, Hun Gi Hong, Dinuka Ariyaratne, Se Jin Im, Tae Jin Kim
Marginal zone (MZ) B cells, which are splenic innate-like B cells that rapidly secrete antibodies (Abs) against blood-borne pathogens, are composed of heterogeneous subpopulations. Here, we showed that MZ B cells can be divided into two distinct subpopulations according to their CD80 expression levels. CD80high MZ B cells exhibited greater Ab-producing, proliferative, and IL-10-secreting capacities than did CD80low MZ B cells. Notably, CD80high MZ B cells survived 2-Gy whole-body irradiation, whereas CD80low MZ B cells were depleted by irradiation and then repleted with one month after irradiation...
March 1, 2024: Cellular & Molecular Immunology
https://read.qxmd.com/read/38415529/effect-of-radiotherapy-on-activating-the-pyroptotic-cell-death-pathway-in-breast-cancer-patients-the-role-of-serum-gsdmd-ct-nlrp3-and-il-18
#26
JOURNAL ARTICLE
Taha I Mahmoud Hewala, Sanaa A El-Benhawy, Yasmine Nagy Elwany, Hossam Ellmasry, Ayman Elrhawy
BACKGROUND: Breast cancer (BC) is the most common form of cancer among women and the second leading cause of cancer-related death worldwide. Several malignancies can be successfully treated with radiation (RT), although radioresistance is still a major contributor to radiotherapy failure. Ionizing radiation (IR) induces pyroptosis in cancer cells. Pyroptosis is a designed method of death connected to routine immunity and directly related to the body ROS content. Objective for the study: The aim of this work was to investigate the role of serum GSDMD-CT, nucleotide-binding domain and leucine-rich-repeat-containing family pyrin 3 (NLRP3) and IL-18 as predictors of pyroptotic cell death mechanism induced by radiotherapy in breast cancer patients...
February 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38415384/towards-tumour-hypoxia-imaging-incorporating-relative-oxygen-extraction-fraction-mapping-of-prostate-with-multi-parametric-quantitative-mri-on-a-1-5t-mr-linac
#27
JOURNAL ARTICLE
Emmanuel Mesny, Benjamin Leporq, Olivier Chapet, Olivier Beuf
Hypoxia plays a central role in tumour radioresistance. Reliable tumour hypoxia imaging would allow the monitoring of tumour response and a more personalized adaptation of radiotherapy planning. Here, we showed a proof of concept of the feasibility and repeatability of relative oxygen extraction fraction (rOEF) mapping of prostate using multi-parametric quantitative MRI (qMRI) achieved for the first time on a 1.5T MR-linac. T2, T2* relaxation times maps, and intra-voxel incoherent motion (IVIM) parametric maps mapping were computed on a 29 years old healthy volunteer...
February 28, 2024: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/38412097/roseburia-intestinalis-sensitizes-colorectal-cancer-to-radiotherapy-through-the-butyrate-or51e1-ralb-axis
#28
JOURNAL ARTICLE
Jiali Dong, Bin Wang, Yunong Xiao, Jia Liu, Qi Wang, Huiwen Xiao, Yuxiao Jin, Zhihong Liu, Zhiyuan Chen, Yiliang Li, Saijun Fan, Yuan Li, Ming Cui
The radioresistant signature of colorectal cancer (CRC) hampers the clinical utility of radiotherapy. Here, we find that fecal microbiota transplantation (FMT) potentiates the tumoricidal effects of radiation and degrades the intertwined adverse events in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC mice. FMT cumulates Roseburia intestinalis (R. intestinalis) in the gastrointestinal tract. Oral gavage of R. intestinalis assembles at the CRC site and synthetizes butyrate, sensitizing CRC to radiation and alleviating intestinal toxicity in primary and CRC hepatic metastasis mouse models...
February 26, 2024: Cell Reports
https://read.qxmd.com/read/38408538/high-definition-ft-ir-reveals-a-synergistic-effect-on-lipid-accumulation-in-prostate-cancer-cells-induced-by-a-combination-of-x-rays-and-radiosensitizing-drugs
#29
JOURNAL ARTICLE
Maciej Roman, Tomasz P Wrobel, Agnieszka Panek, Wojciech M Kwiatek
Radiotherapy is one of the most commonly used cancer therapies with many benefits including low toxicity to healthy tissues. However, a major problem in radiotherapy is cancer radioresistance. To enhance the effect of this kind of therapy several approaches have been proposed such as the use of radiosensitizers. A combined treatment of radiotherapy and radiosensitizing drugs leads to a greater effect on cancer cells than anticipated from the addition of both responses (synergism). In this study, high-definition FT-IR imaging was applied to follow lipid accumulation in prostate cancer cells as a response to X-ray irradiation, radiosensitizing drugs, and a combined treatment of X-rays and the drugs...
February 24, 2024: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
https://read.qxmd.com/read/38408154/octadecyl-gallate-and-lipid-modified-mnse-2-nanoparticles-enhance-radiosensitivity-in-esophageal-squamous-cell-carcinoma-and-promote-radioprotection-in-normal-tissues
#30
JOURNAL ARTICLE
Xinyue Li, He Liu, Wenyan Gao, Qi Yang, Xin Li, Xuantong Zhou, Longwei Wang, Zhihao Lu, Jing Liu, Aiping Luo, Chunying Chen, Zhihua Liu, YuLiang Zhao
Radiotherapy, a widely used therapeutic strategy for esophageal squamous cell carcinoma (ESCC), is always limited by radioresistance of tumor tissues and side-effects on normal tissues. Herein, a signature based on 4 core genes of cGAS-STING pathway, is developed to predict prognosis and assess immune cell infiltration, indicating that the cGAS-STING pathway and radiotherapy efficacy are closely intertwined in ESCC. A novel lipid-modified manganese diselenide nanoparticle (MnSe2 -lipid) with extraordinarily uniform sphere morphology and tumor microenvironment (TME) responsiveness is developed to simultaneously overcome radioresistance and reduce side-effects of radiation...
February 26, 2024: Advanced Materials
https://read.qxmd.com/read/38406264/dbcraf-a-curated-knowledgebase-for-regulation-of-radiation-response-in-human-cancer
#31
JOURNAL ARTICLE
Jie Liu, Jing Li, Fangfang Jin, Qian Li, Guoping Zhao, Lijun Wu, Xiaoyan Li, Junfeng Xia, Na Cheng
Radiation therapy (RT) is one of the primary treatment modalities of cancer, with 40-60% of cancer patients benefiting from RT during their treatment course. The intrinsic radiosensitivity or acquired radioresistance of tumor cells would affect the response to RT and clinical outcomes in patients. Thus, mining the regulatory mechanisms in tumor radiosensitivity or radioresistance that have been verified by biological experiments and computational analysis methods will enhance the overall understanding of RT...
March 2024: NAR cancer
https://read.qxmd.com/read/38403883/cancer-stem-cell-biomarkers-sox2-and-oct4-in-cervical-cancer-patients-undergoing-chemoradiotherapy
#32
JOURNAL ARTICLE
Deep Chakrabarti, Sumaira Qayoom, Kirti Srivastava, Abigail Veravolu Resu, Divya Kukreja, Madhu Mati Goel, U S Singh, Naseem Akhtar, Shiv Rajan, Mranalini Verma, Rajeev Gupta, Madan Lal Brahma Bhatt
BACKGROUND: Cancer stem cell biomarkers SRY (sex-determining region Y)-box 2 (SOX2) and octamer-binding transcription factor 4 (Oct4) account for radioresistance in cervical squamous cell cancers (CSCCs). Their clinical implications are limited and contradictory. METHODS: In this prospective cohort study, we recruited patients with FIGO IB2-IVA CSCC treated with primary chemoradiotherapy on regular follow-up. Tissue biopsy specimens were evaluated for SOX2 and Oct4 expression by immunohistochemistry, quantified by a product of proportion and intensity scores...
February 25, 2024: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/38399767/soil-microbes-and-plant-associated-microbes-in-response-to-radioactive-pollution-may-indirectly-affect-plants-and-insect-herbivores-evidence-for-indirect-field-effects-from-chernobyl-and-fukushima
#33
REVIEW
Ko Sakauchi, Joji M Otaki
The biological impacts of the nuclear accidents in Chernobyl (1986) and Fukushima (2011) on wildlife have been studied in many organisms over decades, mainly from dosimetric perspectives based on laboratory experiments using indicator species. However, ecological perspectives are required to understand indirect field-specific effects among species, which are difficult to evaluate under dosimetric laboratory conditions. From the viewpoint that microbes play a fundamental role in ecosystem function as decomposers and symbionts for plants, we reviewed studies on microbes inhabiting soil and plants in Chernobyl and Fukushima in an attempt to find supporting evidence for indirect field-specific effects on plants and insect herbivores...
February 10, 2024: Microorganisms
https://read.qxmd.com/read/38398123/epigenetic-targeting-to-overcome-radioresistance-in-head-and-neck-cancer
#34
JOURNAL ARTICLE
Iñaki Schniewind, Maria José Besso, Sebastian Klicker, Franziska Maria Schwarz, Wahyu Wijaya Hadiwikarta, Susan Richter, Steffen Löck, Annett Linge, Mechthild Krause, Anna Dubrovska, Michael Baumann, Ina Kurth, Claudia Peitzsch
(1) Background: The sensitivity of head and neck squamous cell carcinoma (HNSCC) to ionizing radiation, among others, is determined by the number of cells with high clonogenic potential and stem-like features. These cellular characteristics are dynamically regulated in response to treatment and may lead to an enrichment of radioresistant cells with a cancer stem cell (CSC) phenotype. Epigenetic mechanisms, particularly DNA and histone methylation, are key regulators of gene-specific transcription and cellular plasticity...
February 9, 2024: Cancers
https://read.qxmd.com/read/38398019/epithelial-mesenchymal-transition-a-fundamental-cellular-and-microenvironmental-process-in-benign-and-malignant-prostate-pathologies
#35
REVIEW
Aviv Philip Goncharov, Nino Vashakidze, Gvantsa Kharaishvili
Epithelial-mesenchymal transition (EMT) is a crucial and fundamental mechanism in many cellular processes, beginning with embryogenesis via tissue remodulation and wound healing, and plays a vital role in tumorigenesis and metastasis formation. EMT is a complex process that involves many transcription factors and genes that enable the tumor cell to leave the primary location, invade the basement membrane, and send metastasis to other tissues. Moreover, it may help the tumor avoid the immune system and establish radioresistance and chemoresistance...
February 11, 2024: Biomedicines
https://read.qxmd.com/read/38396757/glut-3-gene-knockdown-as-a-potential-strategy-to-overcome-glioblastoma-radioresistance
#36
JOURNAL ARTICLE
Gaia Pucci, Luigi Minafra, Valentina Bravatà, Marco Calvaruso, Giuseppina Turturici, Francesco P Cammarata, Gaetano Savoca, Boris Abbate, Giorgio Russo, Vincenzo Cavalieri, Giusi I Forte
The hypoxic pattern of glioblastoma (GBM) is known to be a primary cause of radioresistance. Our study explored the possibility of using gene knockdown of key factors involved in the molecular response to hypoxia, to overcome GBM radioresistance. We used the U87 cell line subjected to chemical hypoxia generated by CoCl2 and exposed to 2 Gy of X-rays, as single or combined treatments, and evaluated gene expression changes of biomarkers involved in the Warburg effect, cell cycle control, and survival to identify the best molecular targets to be knocked-down, among those directly activated by the HIF-1α transcription factor...
February 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38395085/stereotactic-body-radiotherapy-sbrt-for-sacral-metastases-deviation-from-recommended-target-volume-delineation-increases-the-risk-of-local-failure
#37
JOURNAL ARTICLE
Daniel Moore-Palhares, Kang Liang Zeng, Chia-Lin Tseng, Hanbo Chen, Sten Myrehaug, Hany Soliman, Pejman Maralani, Jeremie Larouche, Husain Shakil, Katarzyna Jerzak, Mark Ruschin, Beibei Zhang, Eshetu G Atenafu, Arjun Sahgal, Jay Detsky
PURPOSE: Although spine stereotactic body radiotherapy (SBRT) is considered a standard of care in the mobile spine, mature evidence reporting outcomes specific to sacral metastases is lacking. Furthermore, there is a need to validate the existing sacral SBRT international consensus contouring guidelines to define the optimal contouring approach. We report mature rates of local failure (LF), adverse events, and the impact of contouring deviations in the largest experience to date specific to sacrum SBRT...
February 21, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38389136/mir-378a-5p-exerts-a-radiosensitizing-effect-on-crc-through-lrp8-%C3%AE-catenin-axis
#38
JOURNAL ARTICLE
Guolin Hu, Pengbiao Che, Ling Deng, Lei Liu, Jia Liao, Qi Liu
BACKGROUND: MiRNAs are closely related to tumor radiosensitivity. MiR-378a-5p level is down-regulated in colorectal cancer (CRC). Therefore, this study intends to explore the role of miR-378a-5p in CRC, especially radiosensitivity. METHODS: The expression of miR-378a-5p was analyzed in CRC samples. CRC cell lines were treated with different doses of X-rays. Bioinformatics analysis, dual-luciferase reporter assay and RT-qPCR were used to detect the expressions and binding relationship of miR-378a-5p and low-density lipoprotein receptor-related protein 8 (LRP8)...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38387885/cancer-radiosensitization-nanoagent-to-activate-cgas-sting-pathway-for-molecular-imaging-guided-synergistic-radio-chemo-immunotherapy
#39
JOURNAL ARTICLE
Zede Wu, Qiuyu Li, Kai Zhu, Shuting Zheng, Honglei Hu, Meirong Hou, Li Qi, Siwen Chen, Yikai Xu, Bingxia Zhao, Chenggong Yan
Immunotherapy has emerged as an innovative strategy with the potential to improve outcomes in cancer patients. Recent evidence indicates that radiation-induced DNA damage can activate the cGAS-STING pathway to enhance the antitumor immune response. Even so, only a small fraction of patients currently benefits from radioimmunotherapy due to the radioresistance and the inadequate activation of the cGAS-STING pathway. Herein, we integrated HfO2 nanoparticles (radiosensitizer) and SN38 (chemotherapy drug, STING agonist) into a polydopamine-coated core-shell nanoplatform (HfO2 @PDA/Fe/SN38) to achieve synergistic chemoradiotherapy and immunotherapy...
February 22, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38375610/overexpression-of-yap-confers-radioresistance-to-esophageal-cancer-by-altering-the-tumor-microenvironment
#40
JOURNAL ARTICLE
Guangyue Yao, Mengqing Shao, Yuanliu Nie, Wentao Zhang, Zhe Yang, Qiang Li
This study aimed to investigate the role of yes-associated protein (YAP) in the radiotherapy sensitivity of esophageal squamous cell carcinoma (ESCC). The clonogenic ability of ESCC cells was reduced after YAP silencing and radiotherapy. Overexpression of YAP promoted cell survival and had a synergistic effect with the hypoxic microenvironment. YAP was found to directly regulate hypoxia-inducible factor 1α (HIF-1α). Bioinformatics analysis revealed the involvement of YAP in modulating the tumor immune microenvironment...
February 20, 2024: Environmental Toxicology
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