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Seung-Ah Lee, Yeonyee E Yoon, Jung-Eun Kim, Jin Joo Park, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Jun-Sung Kim, Eun Ju Chun, Young-Suk Cho, Tae-Jin Youn, Cheong Lim, Goo-Young Cho, In-Ho Chae, Kay-Hyun Park, Dong-Ju Choi, Sang Il Choi
The value of late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) for the prediction of functional recovery after surgical revascularization has been previously established. However, the impact of LGE-MRI on the long-term prognosis after coronary artery bypass grafting (CABG) remains incompletely understood. Therefore, we aimed to evaluate the long-term prognostic value of LGE-MRI, based on the presence or absence of left ventricular (LV) dysfunction, in patients with coronary artery disease undergoing CABG...
December 1, 2016: American Journal of Cardiology
Tao Yang, Min-Jie Lu, Han-Song Sun, Yue Tang, Shi-Wei Pan, Shi-Hua Zhao
BACKGROUND: Previous studies have shown that viable myocardium predicts recovery of left ventricular (LV) dysfunction after revascularization. Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional recovery in patients undergoing coronary artery bypass grafting (CABG). METHODS: From November 2009 to September 2012, 63 patients with reduced left ventricular ejection fraction (LVEF) referred for first-time isolated CABG were prospectively enrolled, 52 were included in final analysis...
2013: PloS One
Chris C S Lim, Florim Cuculi, William J van Gaal, Luca Testa, Jayanth R Arnold, Theodoros Karamitsos, Jane M Francis, Janet E Digby, Charalambos Antoniades, Rajesh K Kharbanda, Stefan Neubauer, Stephen Westaby, Adrian P Banning
BACKGROUND: Myocardial injury related to coronary artery bypass grafting (CABG) is poorly characterized, and understanding the characteristic release of biomarkers associated with revascularization injury might provide novel therapeutic opportunities. This study characterized early changes in biomarkers after revascularization injury during on-pump CABG. METHODS: This prospective study comprised 28 patients undergoing on-pump CABG and late gadolinium enhancement (LGE) cardiac magnetic resonance imaging (CMRI) who underwent measurements of cardiac troponin I (cTnI), creatine kinase-MB, and inflammatory markers (C-reactive protein, serum amyloid A, myeloperoxidase, interleukin 6, tumor necrosis factor-α, matrix metalloproteinase 9a, monocyte chemotactic protein-1, plasminogen activator inhibitor-1a) at baseline, at 1, 6, 12, and 24 hours, and at 1 week (inflammatory markers only) post-CABG...
December 2011: Annals of Thoracic Surgery
William J van Gaal, Jayanth R Arnold, Luca Testa, Theo Karamitsos, Chris C S Lim, Francis A Ponnuthurai, Steffen Petersen, Jane M Francis, Joseph Selvanayagam, Rana Sayeed, Nicholas West, Steve Westaby, Stefan Neubauer, Adrian P Banning
AIMS: To compare the frequency and extent of Troponin I and late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) defined injury following PCI compared with CABG in patients with multivessel and/or left main coronary artery disease (CAD), and interpret these finding in light of the new ESC/ACCF/AHA/WHF Task Force definitions for necrosis and infarction. METHODS AND RESULTS: Prospective, registered, single centre randomised controlled trial. Eighty patients with 3 vessel CAD (≥ 50% stenoses), or 2 vessel CAD including a type C lesion in the LAD, and/or left main disease were enrolled...
January 2011: EuroIntervention
Peter Bernhardt, Jochen Spiess, Benny Levenson, Günter Pilz, Berthold Höfling, Vinzenz Hombach, Oliver Strohm
OBJECTIVES: We sought to assess the accuracy of an integrated cardiac magnetic resonance (CMR) protocol for the diagnosis of relevant coronary artery or bypass graft stenosis in patients with suspected coronary artery disease (CAD) or with previously performed percutaneous coronary intervention (PCI) or coronary bypass graft surgery (CABG). BACKGROUND: CMR is suitable for diagnosing inducible myocardial ischemia in patients with suspected CAD and has been proven to be a helpful diagnostic tool for decision of further treatment...
November 2009: JACC. Cardiovascular Imaging
Christoph Klein, Eike Nagel, Rolf Gebker, Sebastian Kelle, Bernhard Schnackenburg, Kristof Graf, Stefan Dreysse, Eckart Fleck
OBJECTIVES: The aim of the study was to evaluate the feasibility and diagnostic performance of the combination of adenosine stress perfusion and late gadolinium enhancement (LGE) in patients after coronary artery bypass graft surgery (CABG). BACKGROUND: Cardiac magnetic resonance (CMR) imaging allows the detection of significant coronary artery disease by adenosine stress perfusion and infarct imaging. Myocardial contrast kinetics may be altered in patients after CABG owing to more complex myocardial perfusion and different distances of the contrast bolus through different bypasses and native coronary vessels...
April 2009: JACC. Cardiovascular Imaging
Peter Hunold, Parwis Massoudy, Claudia Boehm, Thomas Schlosser, Kai Nassenstein, Stephan Knipp, Holger Eggebrecht, Matthias Thielmann, Raimund Erbel, Heinz Jakob, Jörg Barkhausen
The aim of the study was to relate the extent of myocardial late gadolinium enhancement (LGE) in cardiac MRI to intraoperative graft flow in patients undergoing coronary artery bypass graft (CABG) surgery. Thirty-three CAD patients underwent LGE MRI before surgery using an inversion-recovery GRE sequence (turboFLASH). Intraoperative graft flow in Doppler ultrasonography was compared with the scar extent in each coronary vessel territory. One hundred and fourteen grafts were established supplying 86 of the 99 vessel territories...
December 2008: European Radiology
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