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Optimal cpp

Peter A Lee, Margaret Luce, Peter Bacher
BACKGROUND: Peak gonadotropin-releasing hormone or agonist (GnRHa) stimulated luteinizing hormone (LH) testing with leuprolide acetate (LA) is commonly used to document suppression during therapy for central precocious puberty (CPP). The objective of the study was to investigate suitability of using basal LH levels to monitor GnRHa treatment and to determine optimal transition from 1-month to 3-month LA formulations via a post hoc analysis of a randomized, open-label, 6-month study. METHODS: A total of 42 children with CPP, pretreated with 7...
October 14, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Krista Freimann, Piret Arukuusk, Kaido Kurrikoff, Luís Daniel Ferreira Vasconcelos, Kadi-Liis Veiman, Julia Uusna, Helerin Margus, Alfonso T Garcia-Sosa, Margus Pooga, Ülo Langel
As the field of gene therapy progresses, an increasingly urgent need has arisen for efficient and non-toxic vectors for the in vivo delivery of nucleic acids. Cell-penetrating peptides (CPP) are very efficient transfection reagents in vitro, however, their application in vivo needs improvement. To enhance in vivo transfection we designed various CPPs based on previous knowledge of internalization studies and physiochemical properties of NickFect (NF) nanoparticles. We show that increment of the helicity of these Transportan10 analogues improves the transfection efficiency...
November 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Peter Lönn, Apollo D Kacsinta, Xian-Shu Cui, Alexander S Hamil, Manuel Kaulich, Khirud Gogoi, Steven F Dowdy
Bioactive macromolecular peptides and oligonucleotides have significant therapeutic potential. However, due to their size, they have no ability to enter the cytoplasm of cells. Peptide/Protein transduction domains (PTDs), also called cell-penetrating peptides (CPPs), can promote uptake of macromolecules via endocytosis. However, overcoming the rate-limiting step of endosomal escape into the cytoplasm remains a major challenge. Hydrophobic amino acid R groups are known to play a vital role in viral escape from endosomes...
2016: Scientific Reports
Kang Zhou, Shiwei He, Rui Song
Service routes optimization (SRO) of pallet service center should meet customers' demand firstly and then, through the reasonable method of lines organization, realize the shortest path of vehicle driving. The routes optimization of pallet service center is similar to the distribution problems of vehicle routing problem (VRP) and Chinese postman problem (CPP), but it has its own characteristics. Based on the relevant research results, the conditions of determining the number of vehicles, the one way of the route, the constraints of loading, and time windows are fully considered, and a chance constrained programming model with stochastic constraints is constructed taking the shortest path of all vehicles for a delivering (recycling) operation as an objective...
2016: Computational Intelligence and Neuroscience
Young Hyun Song, Eun Kyung Ji, Byung Woo Jeong, Mong Kwon Jung, Eun Young Kim, Dae Ho Yoon
We report on Y3Al5O12: Ce(3+) ceramic phosphor plate (CPP) using nano phosphor for high power laser diode (LD) application for white light in automotive lighting. The prepared CPP shows improved luminous properties as a function of Ce(3+) concentration. The luminous properties of the Y3Al5O12: Ce(3+) CPP nano phosphor are improved when compared to the Y3Al5O12: Ce(3+) CPP with bulk phosphor, and hence, the luminous emittance, luminous flux, and conversion efficiency are improved. The Y3Al5O12: Ce(3+) CPP with an optimal Ce(3+) content of 0...
2016: Scientific Reports
A Kensche, S Pötschke, C Hannig, G Richter, W Hoth-Hannig, M Hannig
For the purpose of erosion prevention the present study aimed to compare the efficacy of two biomimetic products and a fluoride solution to optimize the protective properties of the pellicle. After 1 min of in situ pellicle formation on bovine enamel slabs, 8 subjects adopted CPP-ACP (GC Tooth Mousse), a mouthwash with hydroxyapatite microclusters (Biorepair), or a fluoride based mouthwash (elmex Kariesschutz) for 1 min each. Afterwards, samples were exposed in the oral cavity for 28 min. Native enamel slabs and slabs exposed to the oral cavity for 30 min without any rinse served as controls...
2016: TheScientificWorldJournal
Elodie Belnoue, Wilma Di Berardino-Besson, Hubert Gaertner, Susanna Carboni, Isabelle Dunand-Sauthier, Fabrice Cerini, Else-Marit Suso-Inderberg, Sébastien Wälchli, Stéphane König, Andres M Salazar, Oliver Hartley, Pierre-Yves Dietrich, Paul R Walker, Madiha Derouazi
Cell penetrating peptides (CPPs) from the protein ZEBRA are promising candidates to exploit in therapeutic cancer vaccines, since they can transport antigenic cargos into dendritic cells and induce tumor-specific T cells. Employing CPPs for a given cancer indication will require engineering to include relevant tumor-associated epitopes, administration with an appropriate adjuvant, and testing for antitumor immunity. We assessed the importance of structural characteristics, efficiency of in vitro transduction of target cells, and choice of adjuvant in inducing the two key elements in antitumor immunity, CD4 and CD8 T cells, as well as control of tumor growth in vivo...
September 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
Loredana Luca, Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Mirela Sarandan, Carmen Alina Cradigati, Marius Papurica, Anelore Gruneantu, Raluca Patrut, Corina Vernic, Corina Maria Dumbuleu, Dorel Sandesc
OBJECTIVE: Trauma patient requires a complex therapeutic management because of multiple severe injuries or secondary complications. The most significant injury found in patients with trauma is head injury, which has the greatest impact on mortality. Intracranial pressure (ICP) monitoring is required in severe traumatic head injury because it optimises treatment based on ICP values and cerebral perfusion pressure (CPP). METHODS: From a total of 64 patients admitted in the intensive care unit (ICU) 'Casa Austria', from the Polytraumatology Clinic of the Emergency County Hospital "Pius Brinzeu" Timisoara, Romania, between January 2014 and December 2014; only patients who underwent ICP monitoring (n=10) were analysed...
December 2015: Turkish Journal of Anaesthesiology and Reanimation
Marcel J H Aries, Robin Wesselink, Jan Willem J Elting, Joseph Donnelly, Marek Czosnyka, Ari Ercole, Natasha M Maurits, Peter Smielewski
OBJECTIVE: Cerebrovascular reactivity can provide a continuously updated individualized target for management of cerebral perfusion pressure, termed optimal cerebral perfusion pressure. The objective of this project was to find a way of improving the optimal cerebral perfusion pressure methodology by introducing a new visualization method. DATA SOURCES: Four severe traumatic brain injury patients with intracranial pressure monitoring. DATA EXTRACTION: Data were collected and pre-processed using ICM+ software...
October 2016: Critical Care Medicine
Edward Needham, Charles McFadyen, Virginia Newcombe, Anneliese J Synnot, Marek Czosnyka, David Menon
Traumatic brain injury (TBI) frequently triggers a disruption of cerebral autoregulation. The cerebral perfusion pressure (CPP) at which autoregulation is optimal ("CPPopt") varies between individuals, and can be calculated based on fluctuations between arterial blood pressure and intracranial pressure. This review assesses the effect of individualizing CPP targets to pressure reactivity index (a measure of autoregulation) in patients with TBI. Cochrane Central Register of Controlled Trials, MEDLINE®, Embase, and Cumulative Index of Nursing and Allied Health Literature were searched in March 2015 for studies assessing the effect of targeting CPPopt in TBI...
June 27, 2016: Journal of Neurotrauma
Karidia Konate, Mattias F Lindberg, Anaïs Vaissiere, Carole Jourdan, Gudrun Aldrian, Emmanuel Margeat, Sébastien Deshayes, Prisca Boisguerin
RNA interference provides a powerful technology for specific gene silencing. Therapeutic applications of small interfering RNA (siRNA) however require efficient vehicles for stable complexation and intracellular delivery. In order to enhance their cell delivery, short amphipathic peptides called cell-penetrating peptides (CPPs) have been intensively developed for the last two decades. In this context, the secondary amphipathic peptide CADY has shown to form stable siRNA complexes and to improve their cellular uptake independent of the endosomal pathway...
July 25, 2016: International Journal of Pharmaceutics
Victoria M Wu, Vuk Uskoković
BACKGROUND: Does chemistry govern biology or it is the other way around - that is a broad connotation of the question that this study attempted to answer. METHOD: Comparison was made between the solubility and osteoclastic resorbability of four fundamentally different monophasic calcium phosphate (CP) powders with monodisperse particle size distributions: alkaline hydroxyapatite (HAP), acidic monetite (DCP), β-calcium pyrophosphate (CPP), and amorphous CP (ACP)...
October 2016: Biochimica et Biophysica Acta
Bart Depreitere, Fabian Güiza, Greet Van den Berghe, Martin U Schuhmann, Gottlieb Maier, Ian Piper, Geert Meyfroidt
BACKGROUND: The concept of CPPopt, a variable cerebral perfusion pressure (CPP) target based on cerebrovascular autoregulatory capacity in severe traumatic brain injury (TBI), is promising. CPPopt calculation is based on the continuous plotting of the pressure reactivity Index (PRx) against CPP and requires processing of waveform quality data. The aim of this study is to investigate whether CPPopt can also be calculated based on minute-by-minute data. METHODS: A low-resolution autoregulation index (LAx) was defined as the minute-by-minute intracranial pressure-mean arterial pressure correlation over varying time intervals...
2016: Acta Neurochirurgica. Supplement
Carmen Nagel, Jennifer Diedler, Ines Gerbig, Ellen Heimberg, Martin U Schuhmann, Konstantin Hockel
OBJECTIVE: It could be shown in adults with severe traumatic brain injury (TBI) that the functional status of cerebrovascular autoregulation (AR), determined by the pressure reactivity index (PRx), correlates with and even predicts outcome. We investigated PRx and its correlation with outcome in infant and pediatric TBI. Methods Ten patients (median age 2.8 years, range 1 day to 14 years) with severe TBI (Glasgow Coma Scale score <9 at presentation) underwent long-term computerized intracranial pressure (ICP) and mean arterial pressure (MAP) monitoring using dedicated software for continuous determination of cerebral perfusion pressure (CPP) and PRx...
2016: Acta Neurochirurgica. Supplement
Erhard W Lang, Magdalena Kasprowicz, Peter Smielewski, Edgar Santos, John Pickard, Marek Czosnyka
This study investigates the outcome prediction and calculation of optimal cerebral perfusion pressure (CPPopt) in 307 patients after severe traumatic brain injury (TBI) based on cerebrovascular reactivity calculation of a moving correlation correlation coefficient, named PRx, between mean arterial pressure (ABP) and intracranial pressure (ICP). The correlation coefficient was calculated from simultaneously recorded data using different frequencies. PRx was calculated from oscillations between 0.008 and 0.05Hz and the longPRx (L-PRx) was calculated from oscillations between 0...
2016: Acta Neurochirurgica. Supplement
Fabian Güiza, Geert Meyfroidt, Tsz-Yan Milly Lo, Patricia A Jones, Greet Van den Berghe, Bart Depreitere
This paper describes the use of minute-by-minute monitoring data to determine continuous optimal cerebral perfusion pressure (CPP) recommendations based on the autoregulatory status of pediatric patients with traumatic brain injury. Data from 79 children were retrospectively studied. Optimal CPP recommendations were obtained for the majority of the first 72 h of monitoring time. Actual CPP close to recommended CPP values was significantly associated with better outcome and was a significant independent predictor of better outcome when considering IMPACT model covariates in multivariate logistic regression...
2016: Acta Neurochirurgica. Supplement
Soojin Park, Marek Czosnyka, Peter Smielewski
Controversy exists regarding the brain tissue oxygen (PbtO2) monitor's optimal tip location and what it actually measures. Recent work [2] identified a "PbtO2 change point" (CPPbt), below which PbtO2 displays pressure-passive behavior, showing significant correlation with optimal cerebral perfusion pressure (CPPopt) as defined by the pressure reactivity index (PRx). This would further support the concept of CPPopt [1] as an individualized target. We endeavored to validate these findings and further explore the relationship between PbtO2 and suboptimal CPP...
2016: Acta Neurochirurgica. Supplement
Philip M Lewis, Peter Smielewski, Jeffrey V Rosenfeld, John D Pickard, Marek Czosnyka
We previously showed that the flow-ICP index (Fix), a moving correlation coefficient between intracranial pressure (ICP) and cerebral blood flow velocity (CBFV), had marginally greater prognostic value for patients with traumatic brain injury (TBI) than an index of cerebral autoregulation (mean index, Mx). The aim of this study was to further examine the clinical and physiological relevance of Fix by studying its behaviour during ICP plateau waves in patients with TBI. Twenty-nine recordings of CBFV made during ICP plateau waves were analysed...
2016: Acta Neurochirurgica. Supplement
Steven M Bachrach, Zeina-Christina Zayat
Cycloparaphenylenes (CPP) can serve as both guest and host in a complex. Geometric analysis indicates that optimal binding occurs when the CPP nanohoops differ by five phenyl rings. Employing C-PCM(THF)/ωB97X-D/6-31G(d) computations, we find that the strongest binding does occur when the host and guest differ by five phenyl rings. The guest CPP is modestly inclined relative to the plane of the host CPP except when the host and guest differ by four phenyl rings, when the inclination angle becomes >40°. The distortion/interaction model shows that interaction dominates and is best when the host and guest differ by five phenyl rings...
June 3, 2016: Journal of Organic Chemistry
Mehrnaz Pajoumand, Joseph A Kufera, Brandon W Bonds, Sandeep Devabhakthuni, Sharon Boswell, Kathleen Hesselton, Thomas M Scalea, Deborah M Stein
BACKGROUND: In patients with traumatic brain injury (TBI), optimizing sedation is challenging because maintaining a clinical examination is important in being able to detect neurological deterioration. Propofol (PROP) is frequently used as a sedative in TBI since it has been shown to reduce the cerebral metabolic rate, but it may lead to PROP-related infusion syndrome and hemodynamic compromise. Dexmedetomidine (DEX) is a sedative that produces minimal respiratory depression with opioid-sparing effects...
August 2016: Journal of Trauma and Acute Care Surgery
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