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Optimal cpp

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https://www.readbyqxmd.com/read/29757340/polyethylene-glycol-and-octa-arginine-dual-functionalized-nanographene-oxide-an-optimization-for-efficient-nucleic-acid-delivery
#1
Rana Imani, Satya Prakash, Hojatollah Vali, Shahab Faghihi
The successful application of nucleic acid-based therapy for the treatment of various cancers is largely dependent on a safe and efficient delivery system. A dual-functionalized graphene oxide (GO)-based nanocarrier with the conjugation of aminated-polyethylene glycol (PEG-diamine) and octa-arginine (R8) for the intracellular delivery of nucleic acids is proposed. The functionalized sites are covalently co-conjugated and the PEG : R8 molar ratio is optimized at 10 : 1 to achieve a hydrocolloidally stable size of 252 ± 2...
May 14, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29750651/predictors-of-bone-maturation-growth-rate-and-adult-height-in-children-with-central-precocious-puberty-treated-with-depot-leuprolide-acetate
#2
Karen O Klein, Sanja Dragnic, Ahmed M Soliman, Peter Bacher
BACKGROUND: Children with central precocious puberty (CPP) are treated with gonadotropin-releasing hormone agonists (GnRHa) to suppress puberty. Optimizing treatment outcomes continues to be studied. The relationships between growth, rate of bone maturation (bone age/chronological age [ΔBA/ΔCA]), luteinizing hormone (LH), predicted adult stature (PAS), as well as variables influencing these outcomes, were studied in children treated with depot leuprolide (LA Depot) Methods: Subjects (64 girls, seven boys) with CPP received LA Depot every 3 months for up to 42 months...
May 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29740070/flood-conditioned-place-aversion-as-a-novel-non-pharmacological-aversive-learning-procedure-in-mice
#3
Koral Goltseker, Segev Barak
The place conditioning paradigm is an efficient, widely-used method to study mechanisms that underlie appetitive or aversive learning and memory processes. However, pharmacological agents used to induce conditioned place preference (CPP) or aversion (CPA) can per se interfere with learning and memory processing, hence confounding the results. Therefore, non-pharmacological place conditioning procedures are of high importance. Here, we introduce a novel procedure for induction of CPA in mice, by water flooding...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650049/variation-in-general-supportive-and-preventive-intensive-care-management-of-traumatic-brain-injury-a-survey-in-66-neurotrauma-centers-participating-in-the-collaborative-european-neurotrauma-effectiveness-research-in-traumatic-brain-injury-center-tbi-study
#4
Jilske A Huijben, Victor Volovici, Maryse C Cnossen, Iain K Haitsma, Nino Stocchetti, Andrew I R Maas, David K Menon, Ari Ercole, Giuseppe Citerio, David Nelson, Suzanne Polinder, Ewout W Steyerberg, Hester F Lingsma, Mathieu van der Jagt
BACKGROUND: General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess and quantify variation in perceptions on intensive care unit (ICU) management of patients with TBI in European neurotrauma centers. METHODS: We performed a survey as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study...
April 13, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29624527/dezocine-alleviates-morphine-induced-dependence-in-rats
#5
Fei-Xiang Wu, Hasan Babazada, Hao Gao, Xi-Ping Huang, Chun-Hua Xi, Chun-Hua Chen, Jin Xi, Wei-Feng Yu, Renyu Liu
BACKGROUND: Opioid dependence is a major public health issue without optimal therapeutics. This study investigates the potential therapeutic effect of dezocine, a nonaddictive opioid, in opioid dependence in rat models. METHODS: Dezocine was administered intraperitoneally to a morphine-dependent rat model to investigate its effect on withdrawal and conditioned place preference (CPP). Effect of dezocine on morphine withdrawal syndrome and CPP was analyzed using 2-way analysis of variance (ANOVA) followed by Tukey's post hoc test...
April 5, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29621570/mne-scan-software-for-real-time-processing-of-electrophysiological-data
#6
Lorenz Esch, Limin Sun, Viktor Klüber, Seok Lew, Daniel Baumgarten, P Ellen Grant, Yoshio Okada, Jens Haueisen, Matti S Hämäläinen, Christoph Dinh
BACKGROUND: Magnetoencephalography (MEG) and Electroencephalography (EEG) are noninvasive techniques to study the electrophysiological activity of the human brain. Thus, they are well suited for real-time monitoring and analysis of neuronal activity. Real-time MEG/EEG data processing allows adjustment of the stimuli to the subject's responses for optimizing the acquired information especially by providing dynamically changing displays to enable neurofeedback. NEW METHOD: We introduce MNE Scan, an acquisition and real-time analysis software based on the multipurpose software library MNE-CPP...
April 2, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29541487/pbto-2-monitoring-in-normobaric-hyperoxia-targeted-therapy-in-acute-subarachnoidal-hemorrhage
#7
Vasilije Stambolija, Martina Miklić Bublić, Marin Lozić, Jakob Nemir, Miroslav Ščap
Background: Low brain tissue oxygen tension (PbtO2 ), or brain hypoxia, is an independent predictor of poor outcome. Increasing inspirational fraction of oxygen could have a significant influence on treating lower PbtO2 . Combined PbtO2 therapy, compared to the approach that focus only on regulation of cerebral perfusion pressure and intracranial pressure, shows better patient outcomes. Monitoring of PbtO2 could be helpful in individualizing treatment, preventing or limiting secondary brain injury, and maintaining better patient outcome...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29492582/statistical-signal-properties-of-the-pressure-reactivity-index-prx
#8
Sophie Kelly, Steven M Bishop, Ari Ercole
OBJECTIVES: The pressure-reactivity index (PRx) is defined in terms of the moving correlation coefficient between intracranial pressure (ICP) and mean arterial pressure (MAP) and is a measure of cerebral autoregulation ability. Plots of PRx against cerebral perfusion pressure (CPP) show a U-shaped behaviour: the minimum reflecting optimal cerebral autoregulation (CPPopt). However U-shaped behaviour may also occur by chance. To date there has been no evaluation of the statistical properties of these signals...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492563/pressure-reactivity-based-optimal-cerebral-perfusion-pressure-in-a-traumatic-brain-injury-cohort
#9
J Donnelly, M Czosnyka, H Adams, C Robba, L A Steiner, D Cardim, B Cabella, X Liu, A Ercole, P J Hutchinson, D K Menon, M J H Aries, P Smielewski
OBJECTIVES: Retrospective data from patients with severe traumatic brain injury (TBI) indicate that deviation from the continuously calculated pressure reactivity-based "optimal" cerebral perfusion pressure (CPPopt) is associated with worse patient outcome. The objective of this study was to assess the relationship between prospectively collected CPPopt data and patient outcome after TBI. METHODS: We prospectively collected intracranial pressure (ICP) monitoring data from 231 patients with severe TBI at Addenbrooke's Hospital, UK...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492557/deriving-the-prx-and-cppopt-from-0-2-hz-data-establishing-generalizability-to-bedmaster-users
#10
Murad Megjhani, Kalijah Terilli, Andrew Martin, Angela Velazquez, Jan Claassen, David Roh, Sachin Agarwal, Peter Smielewski, Amelia K Boehme, J Michael Schmidt, Soojin Park
OBJECTIVE: The objective was to explore the validity of industry-parameterized vital signs in the generation of pressure reactivity index (PRx) and optimal cerebral perfusion pressure (CPPopt) values. MATERIALS AND METHODS: Ten patients with intracranial pressure (ICP) monitors from 2008 to 2013 in a tertiary care hospital were included. Arterial blood pressure (ABP) and ICP were sampled at 240 Hz (of waveform data) and 0.2 Hz (of parameterized data produced by heuristic industry proprietary algorithms)...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492550/occurrence-of-cppopt-values-in-uncorrelated-icp-and-abp-time-series
#11
M Cabeleira, M Czosnyka, X Liu, J Donnelly, P Smielewski
OBJECTIVES: Optimal cerebral perfusion pressure (CPPopt) is a concept that uses the pressure reactivity (PRx)-CPP relationship over a given period to find a value of CPP at which PRx shows best autoregulation. It has been proposed that this relationship be modelled by a U-shaped curve, where the minimum is interpreted as being the CPP value that corresponds to the strongest autoregulation. Owing to the nature of the calculation and the signals involved in it, the occurrence of CPPopt curves generated by non-physiological variations of intracranial pressure (ICP) and arterial blood pressure (ABP), termed here "false positives", is possible...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492533/is-there-a-relationship-between-optimal-cerebral-perfusion-pressure-guided-management-and-pao-2-fio-2-ratio-after-severe-traumatic-brain-injury
#12
M Moreira, D Fernandes, E Pereira, E Monteiro, R Pascoa, C Dias
OBJECTIVE: Severe traumatic brain injury (TBI) management has been associated with adult respiratory distress syndrome (ARDS) in previous literature. We aimed to investigate the relationships between optimal CPP-guided management, ventilation parameters over time and outcome after severe TBI. MATERIALS AND METHODS: We performed retrospective analysis of recorded data from 38 patients admitted to the NCCU after severe TBI, managed with optimal cerebral perfusion pressure (CPPopt)-guided therapy, calculated using pressure reactivity index (PRx)...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492532/visualisation-of-the-optimal-cerebral-perfusion-landscape-in-severe-traumatic-brain-injury-patients
#13
Ari Ercole, Peter Smielewski, Marcel J H Aries, Robin Wesselink, Jan Willem J Elting, Joseph Donnelly, Marek Czosnyka, Natasha M Maurits
OBJECTIVE: An 'optimal' cerebral perfusion pressure (CPPopt) can be defined as the point on the CPP scale corresponding to the greatest autoregulatory capacity. This can be established by examining the pressure reactivity index PRx-CPP relationship, which is approximately U-shaped but suffers from noise and missing data. In this paper, we present a method for plotting the whole PRx-CPP relationship curve against time in the form of a colour-coded map depicting the 'landscape' of that relationship extending back for several hours and to display this robustly at the bedside...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29492529/kidsbrainit-a-new-multi-centre-multi-disciplinary-multi-national-paediatric-brain-monitoring-collaboration
#14
T Lo, I Piper, B Depreitere, G Meyfroidt, M Poca, J Sahuquillo, T Durduran, P Enblad, P Nilsson, A Ragauskas, K Kiening, K Morris, R Agbeko, R Levin, J Weitz, C Park, P Davis
OBJECTIVES: Validated optimal cerebral perfusion pressure (CPP) treatment thresholds in children do not exist. To improve the intensive care unit (ICU) management of the paediatric traumatic brain injury (TBI) population, we are forming a new paediatric multi-centre collaboration to recruit standardised ICU data for running and reporting upon models for assessing autoregulation and optimal CCP (CPPopt). MATERIALS AND METHODS: We are adapting the adult BrainIT group's approach to develop a new Paediatric Brain Monitoring and Information Technology Group (KidsBrainIT), which will include a repository to store prospectively collected high-resolution physiological, clinical, and outcome data...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29386483/exploration-of-the-key-factors-for-optimizing-the-in-vivo-oral-delivery-of-insulin-by-using-a-noncovalent-strategy-with-cell-penetrating-peptides
#15
Noriyasu Kamei, Chikako Shigei, Ryota Hasegawa, Mariko Takeda-Morishita
This present study aimed to determine the optimal oral insulin delivery conditions that would maximize the utility of cell-penetrating peptides (CPPs) by using a noncovalent strategy. We first compared the effectiveness of two potential CPPs, penetratin and its analog PenetraMax, as absorption enhancers for insulin. The combined effect was evaluated under in vivo oral administration conditions. Both D-forms of CPPs were highly effective for increasing the oral absorption of insulin, and D-PenetraMax showed a more rapid onset of absorption enhancement effects compared with those of D-penetratin...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29385047/interface-tailoring-effect-for-heusler-based-cpp-gmr-with-an-l1%C3%A2-type-ag%C3%A2-mg-spacer
#16
Takahide Kubota, Yusuke Ina, Zhenchao Wen, Koki Takanashi
Current perpendicular-to-plane (CPP) giant magnetoresistance (GMR) effects are of interest in a possible application of magnetic sensor elements, such as read-head of hard disk drives. To improve the junction performance, the interface tailoring effects were investigated for the Heulser alloy, Co₂Fe0.4 Mn0.6 Si (CFMS), based CPP-GMR junctions with an L 1 2 -Ag₃Mg ordered alloy spacer. Ultra-thin Fe or Mg inserts were utilized for the CFMS/Ag₃Mg interfaces, and CPP-GMR at low bias current density, J and the J dependence were evaluated for the junctions...
January 31, 2018: Materials
https://www.readbyqxmd.com/read/29344708/treatment-of-combined-traumatic-brain-injury-and-hemorrhagic-shock-with-fractionated-blood-products-versus-fresh-whole-blood-in-a-rat-model
#17
Akiva Leibowitz, Evgeni Brotfain, Leonid Koyfman, Moti Klein, Shmuel Hess, Alexander Zlotnik, Matthew Boyko
INTRODUCTION: Treatment of combined traumatic brain injury and hemorrhagic shock, poses a particular challenge due to the possible conflicting consequences. While restoring diminished volume is the treatment goal for hypovolemia, maintaining adequate cerebral perfusion pressure and avoidance of secondary damage remains a treatment goal for the injured brain. Various treatment modalities have been proposed, but the optimal resuscitation fluid and goals have not yet been clearly defined...
January 17, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29303375/structure-optimisation-to-improve-the-delivery-efficiency-and-cell-selectivity-of-a-tumour-targeting-cell-penetrating-peptide
#18
Xue-Wei Cao, Xu-Zhong Yang, Xuan Du, Long-Yun Fu, Tao-Zhu Zhang, Han-Wen Shan, Jian Zhao, Fu-Jun Wang
Cell-penetrating peptide (CPP) is used for the delivery of biomacromolecules across the cell membrane and is limited in cancer therapy due to the lack of cell selectivity. Epidermal growth factor receptor (EGFR) has been widely used in clinical targeted therapy for tumours. Here, we reported a novel tumour targeting cell-penetrating peptide (TCPP), EHB (ELBD-C6H) with 20-fold and 3000-fold greater transmembrane ability and tumour cell selectivity than our previously reported S3-HBD and classic CPP TAT, respectively...
January 16, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29302188/migraine-in-young-females-with-irritable-bowel-syndrome-still-a-challenge
#19
Doina Georgescu, Daniela Reisz, Camelia Vidita Gurban, Liviu Andrei Georgescu, Ioana Ionita, Oana Elena Ancusa, Daniel Lighezan
Migraine without aura is frequently reported in female patients with irritable bowel syndrome (IBS), but knowledge about the relationship between these two conditions is still lacking. This study was aimed to explore the particularities of migraine without aura in young female patients with IBS in order to establish a possible link between them. From a cohort of young female patients hospitalized with IBS in the Internal Medicine Department, 30 joined this pilot study, and they were assigned into two groups on the basis of presence or absence of migraine...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29298527/a-narrative-review-of-the-clinical-application-of-pressure-reactiviy-indices-in-the-neurocritical-care-unit
#20
Stephen Copplestone, Jessie Welbourne
Pressure reactivity indices are used in clinical research as a surrogate marker of the ability of the cerebrovasculature to maintain cerebral autoregulation. The use of pressure reactivity indices in patients with neurological injury represents a potential to move away from population-based physiological targets used in guidelines to individualized physiological targets. The aim of this review is to describe the underlying principles and development of pressure reactivity indices, alongside a critique of how they have been used in clinical research, including their limitations...
January 4, 2018: British Journal of Neurosurgery
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