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https://www.readbyqxmd.com/read/28645887/perspectives-of-family-members-on-using-technology-in-youth-mental-health-care-a-qualitative-study
#1
Shalini Lal, Winnie Daniel, Lysanne Rivard
BACKGROUND: Information and communication technologies (ICTs) are increasingly recognized as having an important role in the delivery of mental health services for youth. Recent studies have evaluated young people's access and use of technology, as well as their perspectives on using technology to receive mental health information, services, and support; however, limited attention has been given to the perspectives of family members in this regard. OBJECTIVE: The aim of this study was to explore the perspectives of family members on the use of ICTs to deliver mental health services to youth within the context of specialized early intervention for a first-episode psychosis (FEP)...
June 23, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28644611/transient-fiber-mats-of-electrospun-poly-propylene-carbonate-composites-with-remarkable-mechanical-strength
#2
Peter Ohlendorf, Alexander Ruyack, Amanda K Leonardi, Chengjian Shi, Christine Cuppoletti, Ian Bruce, Amit Lal, Christopher K Ober
Polymers with a triggered decomposition are attractive for an array of applications ranging from patterning to transient packaging materials as well as for environmental protection. This work showed for the first time UV and thermally triggered transience in fiber mats using poly(propylene carbonate) (PPC) composites. The electrospun PPC-composite fiber mats combine excellent decomposition performance (due to the high surface to volume ratio) with high stiffness and thus represent a new class of materials enabling innovative applications such as transient filter materials, short-time plant protection materials as well as temporary lightweight materials for aerospace engineering...
June 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28642247/clinical-benefit-of-the-fifa-11-programme-for-the-prevention-of-hamstring-and-lateral-ankle-ligament-injuries-among-amateur-soccer-players
#3
Rauf Nouni-Garcia, Concepcion Carratala-Munuera, Domingo Orozco-Beltran, Adriana Lopez-Pineda, María Rosario Asensio-Garcia, Vicente F Gil-Guillen
OBJECTIVE: To analyse the relationship between the implementation of 'the 11' protocol during the regular season in a men's amateur soccer team and the rate of hamstring and lateral ankle ligament (LAL) injuries, and to estimate the clinical benefit of the programme according to the type of injury and the position field. METHODS: This cohort study was conducted in two different men's amateur soccer teams. During two seasons, the exposed group (43 players) performed 'the 11' protocol twice a week, and the unexposed group (43 players) performed the regular training programme...
June 22, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28636400/click-biotinylation-of-plga-template-for-biotin-receptor-oriented-delivery-of-doxorubicin-hydrochloride-in-4t1-cell-induced-breast-cancer
#4
Yuvraj Singh, K K Durga Rao Viswanadham, Arun Kumar Jajoriya, Jayagopal Meher, Kavit Raval, Swati Jaiswal, Jayant Dewangan, H K Bora, Srikanta Kumar Rath, Jawahar Lal, Durga Prasad Mishra, Manish Kumar Chourasia
PLGA was functionalized with PEG and biotin using click chemistry to generate a biotin receptor targeted copolymer (Biotinylated-PEG-PLGA) which in turn was used to fabricate ultrafine nanoparticles (BPNP) of doxorubicin hydrochloride (DOX) for effective delivery in 4T1 cell induced breast cancer. However adequate entrapment of a hydrophilic bioactive like DOX in a hydrophobic polymer system made of PLGA is not usually possible. We therefore modified a conventional W/O/W emulsion method by utilizing ammonium chloride in the external phase to constrain DOX in dissolved polymer phase by supressing its inherent aqueous solubility as per common ion effect...
June 21, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28636368/probing-the-mechanism-of-lal-32-a-gold-nanoparticle-based-antibiotic-discovered-through-small-molecule-variable-ligand-display
#5
Rose Byrne-Nash, Danielle Lucero, Niki Osbaugh, Roberta J Melander, Christian Melander, Daniel L Feldheim
The unrelenting rise of antimicrobial resistant bacteria has necessitated the search for novel antibiotic solutions. Herein we describe further mechanistic studies on a 2.0 nm diameter gold nanoparticle-based antibiotic (designated LAL-32). This antibiotic exhibits bactericidal activity against the Gram-negative bacterium Escherichia coli at 1.0 μΜ, a concentration significantly lower than several clinically available antibiotics (such as ampicillin and gentamicin), and acute treatment with LAL-32 does not give rise to spontaneous resistant mutants...
June 21, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28634546/low-hemoglobin-among-pregnant-women-in-midwives-practice-of-primary-health-care-jatinangor-indonesia-iron-deficiency-anemia-or-%C3%AE-thalassemia-trait
#6
Ari Indra Susanti, Edhyana Sahiratmadja, Gatot Winarno, Adhi Kristianto Sugianli, Herman Susanto, Ramdan Panigoro
Low hemoglobin (Hb) or anemia is common among pregnant women in developing countries which may cause adverse pregnancy outcomes and maternal deaths. Our study aimed to assess Hb level measured by midwives in primary health care facility at rural area of Jatinangor, Indonesia, and to explore whether the anemia was due to iron deficiency (IDA) or β-thalassemia trait (β-TT). Pregnant women (n = 105) had finger prick test for Hb level during a regular antenatal care examination from October to November 2016. Hb level by finger prick test was compared with venous blood, measured by complete blood count (CBC)...
2017: Anemia
https://www.readbyqxmd.com/read/28633434/psip1-p75-promotes-tumorigenicity-in-breast-cancer-cells-by-promoting-the-transcription-of-cell-cycle-genes
#7
Deepak K Singh, Omid Gholamalamdari, Mahdieh Jadaliha, Xiao Ling Li, Yo-Chuen Lin, Yang Zhang, Shuomeng Guang, Seyedsasan Hashemikhabir, Saumya Tiwari, Yuelin J Zhu, Abid Khan, Anu Thomas, Arindam Chakraborty, Virgilia Macias, Andre K Balla, Rohit Bhargava, Sarath Chandra Janga, Jian Ma, Supriya G Prasanth, Ashish Lal, Kannanganattu V Prasanth
Breast cancer (BC) is a highly heterogeneous disease, both at the pathological and molecular level, and several chromatin-associated proteins play crucial roles in breast cancer initiation and progression. Here, we demonstrate the role of PSIP1 (PC4 and SF2 interacting protein)/p75 (LEDGF) in breast cancer progression. PSIP1/p75, previously identified as a chromatin-adaptor protein, is found to be upregulated in basal-like/triple negative breast cancer (TNBC) patient samples and cell lines. Immunohistochemistry in tissue arrays showed elevated levels of PSIP1 in metastatic invasive ductal carcinoma...
June 17, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28633177/give-me-what-s-in-your-heart
#8
Nidhi Lal
No abstract text is available yet for this article.
June 2017: Family Medicine
https://www.readbyqxmd.com/read/28631971/rapidly-progressive-dementia-an-unusual-cause
#9
Aastha Takkar, Veenu Singla, Manish Modi, Vivek Gupta, Manoj K Goyal, Vivek Lal
Brain metastases are known to be present with a history of increased intra-cranial pressure headache, seizures or altered sensorium. Corresponding to the clinical brain metastases are the most feared complication of a systemic cancer. Classically, brain metastases are associated with significant morbidity and are known to present with a history of increased intracranial pressure headache, seizures or altered sensorium. Neuroimaging is usually suggestive of massive peri-lesional edema and mass effect surrounding the space occupying lesions...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28629045/chitosan-based-in-situ-forming-polyelectrolyte-complexes-a-potential-sustained-drug-delivery-polymeric-carrier-for-high-dose-drugs
#10
Niharika Lal, Juhi Dubey, Praveen Gaur, Navneet Verma, Anurag Verma
The present study investigated the feasibility of using combination of Cationic and anionic polymers as sustained release carrier for the delivery of high dose gastric acid soluble model drug Paracetamol. Various formulations were prepared using wet granulation technique. Briefly a cooled (4°C) neutral solution of chitosan (CH) was combined with cooled aqueous solution (4°C) of anionic polymer such as Gum Ghatti (GG) and Xanthan gum (XG). This polyelectrolyte solution was then used to granulate the model drug Paracetamol...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28624002/pathophysiology-of-venous-ulceration
#11
REVIEW
Joel M Crawford, Brajesh K Lal, Walter N Durán, Peter J Pappas
Our understanding of the pathophysiologic process of venous ulceration has dramatically increased during the past two decades because of dedicated, venous-specific basic science research. Currently, the mechanisms regulating venous ulceration are a combination of macroscopic and microscopic pathologic processes. Macroscopic alterations refer to pathologic processes related to varicose vein formation, vein wall architecture, and cellular abnormalities that impair venous function. These processes are primarily caused by genetic factors that lead to the destruction of normal vein wall architecture and venous hypertension...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28621471/tuberculosis-breast-and-its-coexistence-with-carcinoma-breast-a-retrospective-analysis-at-a-tertiary-care-hospital-in-india
#12
Gulzar Ahmad Bhat, Vidhya Gunasekaran, Pawan Lal, Nita Khurana
No abstract text is available yet for this article.
June 16, 2017: Breast Journal
https://www.readbyqxmd.com/read/28619312/pay-dirt-human-health-depends-on-soil-health
#13
EDITORIAL
Kathi J Kemper, Rattan Lal
No abstract text is available yet for this article.
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28616953/universal-liquid-phase-laser-fabrication-of-various-nano-metals-encapsulated-by-ultrathin-carbon-shells-for-deep-uv-plasmonics
#14
Miao Yu, Chao Yang, Xiao-Ming Li, Tian-Yu Lei, Hao-Xuan Sun, Li-Ping Dai, Yu Gu, Xue Ning, Ting Zhou, Chao Wang, Hai-Bo Zeng, Jie Xiong
The exploration of localized surface plasmon resonance (LSPR) beyond the usual visible waveband, for example within the ultraviolet (UV) or deep-ultraviolet (D-UV) regions, is of great significance due to its unique applications in secret communications and optics. However, it is still challenging to universally synthesize the corresponding metal nanostructures due to their high activity. Herein, we report a universal, eco-friendly, facile and rapid synthesis of various nano-metals encapsulated by ultrathin carbon shells, significantly with a remarkable deep-UV LSPR characteristic, via a liquid-phase laser fabrication method...
June 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28615883/clinicobiochemical-changes-in-ivermectin-toxicity-in-doberman-pinscher-pups
#15
Sahadeb Dey, Nitin P Kurade, Kishore Lal Khurana, Ananya Dan
This study is based on naturally intoxicated Doberman pinscher pups. Six Doberman pinscher pups were overdosed 50 times of recommended ivermectin dose by the pet owner and presented to Referral Veterinary Polyclinic section of this institute in a state of coma. The pups were unable to hold their head up and had no pupillary reflex. The pups were examined clinically and samples of blood were taken for haemato-biochemical studies, before and after treatment. During intoxication there was marked haemoconcentration, increase in values of serum creatinine phosphokinase, gamma glutamyl transpeptidase but decrease in serum glucose levels...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28615867/first-record-of-a-rare-transversotrematid-cercaria-larva-trematoda-digenea-from-rajasthan-india-focus-on-seasonal-occurrence-and-host-specificity-of-diverse-cercariae
#16
Shanti Lal Choubisa, Vishva Jeet Jaroli, Zulfiya Sheikh
During the survey of freshwater snail hosts and their digenean larval trematode parasites, a rare cercaria larva belonging to family Transversotrematidae and subclass Digenea (Trematoda) was recovered from the snail species Melanoides striatella tuberculata inhabiting perennial Som river of Udaipur district, Rajasthan, India. More than 28 % mature specimens of these snails were found to be infected with transversotrematid cercaria larvae in the spring season. Body of this cercaria is large, bowl-shaped, biocellate, spinose, transparent and laterally extended having two pigmented eye spots, two hold fast organs extended from the junction of body and tail, large tail with two foliated furcal rami, and cyclocoel intestinal caeca...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28615446/lysosome-mediated-degradation-of-a-distinct-pool-of-lipid-droplets-during-hepatic-stellate-cell-activation
#17
Maidina Tuohetahuntila, Martijn R Molenaar, Bart Spee, Jos F Brouwers, Richard Wubbolts, Martin Houweling, Cong Yan, Hong Du, Brian C VanderVen, Arie B Vaandrager, J Bernd Helms
Activation of hepatic stellate cells (HSCs) is a critical step in the development of liver fibrosis. During activation, HSCs lose their lipid droplets (LDs) containing triacylglycerols (TAGs), cholesteryl esters (CEs) and retinyl esters (REs). We previously provided evidence for the presence of two distinct LD pools, a pre-existing and a dynamic LD pool. Here we investigate the mechanisms of neutral lipid metabolism in the pre-existing LD pool. To investigate the involvement of lysosomal degradation of neutral lipids, we studied the effect of lalistat, a specific lysosomal acid lipase (LAL/Lipa) inhibitor on LD degradation in HSCs during activation in vitro The LAL-inhibitor increased the levels of TAG, CE and RE in both rat and mouse HSCs...
June 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28613108/a-novel-phylogroup-of-pseudomonas-cichorii-identified-following-an-unusual-disease-outbreak-on-tomato
#18
Sujan Timilsina, Heather Adkison, Anna Louise Testen, Eric A Newberry, Sally A Miller, Mathews Lal Paret, Gerald V Minsavage, Erica M Goss, Jeffrey B Jones, Gary E Vallad
Recently, in Central Florida tomato production fields, tomato foliage and fruit were observed with symptoms similar to bacterial speck. Fluorescent pseudomonads were consistently isolated and the strains were characterized by standard LOPAT tests, pathogenicity tests and genetic characterization using 16S rRNA sequences and multilocus sequence analysis of conserved housekeeping genes. LOPAT test results indicated the strains were likely P. cichorii. These strains were pathogenic on tomato and were also pathogenic on lettuce, the host for the type strain of P...
June 14, 2017: Phytopathology
https://www.readbyqxmd.com/read/28612634/lysosomal-acid-lipase-deficiency-a-form-of-non-obese-fatty-liver-disease-nofld
#19
H H A-Kader
With the growing obesity epidemic, nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the leading causes of liver disease worldwide. Although obesity is a main risk factor for the development of NAFLD, it can also develop in lean subjects and can be encountered in different clinical setting and in association with an array of genetic, metabolic, nutritional, infectious and drug-induced disorders. Areas covered: This article discusses causes of fatty liver in non-obese subjects focusing on Lysosomal acid lipase deficiency (LAL-D), a commonly overlooked disorder reviewing its prevalence, genetics, pathogenesis, clinical features, diagnosis and treatment...
June 14, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28612224/extrahepatic-portal-venous-obstruction-what-should-be-the-mainstay-of-treatment
#20
Richa Lal, Moinak Sen Sarma, Manish K Gupta
The two cornerstones of management for Extrahepatic portal vein obstruction (EHPVO) are endotherapy and surgery [Porto-systemic shunts (PSS)/Mesorex bypass (MRB)]. Endotherapy is the mainstay of treatment for acute variceal bleed control and has also been used extensively for secondary prophylaxis till variceal eradication is achieved. However, long-term follow-up beyond endoscopic eradication of esophageal varices (EEEV) indicates that there are numerous delayed bleed and non bleed sequelae of EHPVO, which merit surgery as a definitive procedure to decompress the hypertensive portal venous system...
June 14, 2017: Indian Journal of Pediatrics
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