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https://www.readbyqxmd.com/read/28210877/quantum-mechanical-treatment-of-as-3-thiol-model-compounds-implication-for-the-core-structure-of-as-iii-metallothionein
#1
Roobee Garla, Narinder Kaur, Mohinder Pal Bansal, Mohan Lal Garg, Biraja Prasad Mohanty
Exposure to inorganic arsenic (As) is one of the major health concerns in several regions around the world. Binding of As(III) with thiols is central to the mechanisms related to its toxicity, detoxification, and therapeutic effects. Due to its high thiol content, metallothionein (MT) is presumed to play an important role in case of arsenic toxicity. Consequences of these As-thiol interactions are not yet clear due to various difficulties in the characterization of arsenic bound proteins by spectroscopic techniques...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28210382/paraneoplastic-dermatomyositis-with-cutaneous-and-myopathic-disease-responsive-to-adrenocorticotropic-hormone-therapy
#2
Marisa Wolff, Christopher Mancuso, Karan Lal, Damian Dicostanzo, Charles Gropper
Dermatomyositis is a myopathic or amyopathic autoimmune connective tissue disease that presents with classic dermatologic findings ranging from: poikilodermatous photosensitivity (shawl sign), eyelid edema and violaceous-pigmentation (heliotrope sign), lichenoid eruptions on the knuckles and elbows (Gottron's sign), periungual telangiectasias, and ragged cuticles (Samitz sign). Up to 30 percent of adult-onset cases of dermatomyositis may represent a paraneoplastic syndrome warranting a thorough work-up for malignancy...
January 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28207010/advances-in-minimally-invasive-and-noninvasive-treatments-for-submental-fat
#3
Joanna Dong, Yasmin Amir, Gary Goldenberg
Submental fat (SMF) accumulation is a cosmetically distressing concern for which there have been recent advances in minimally invasive and noninvasive therapeutic options. In this article, we review the newest treatments available for SMF, including laser-assisted lipolysis (LAL), radiofrequency (RF)-assisted lipolysis, deoxycholic acid (DCA), and noninvasive devices. These treatments provide additional options for patients seeking nonsurgical approaches to treatment of SMF.
January 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28206860/editorial-acknowledgments
#4
Lal S Mian
No abstract text is available yet for this article.
December 2016: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/28204540/cost-effectiveness-analysis-of-malaria-rapid-diagnostic-tests-for-appropriate-treatment-of-malaria-at-the-community-level-in-uganda
#5
Kristian S Hansen, Richard Ndyomugyenyi, Pascal Magnussen, Sham Lal, Siân E Clarke
No abstract text is available yet for this article.
February 15, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28202405/urinary-leukotriene-e4-to-determine-aspirin-intolerance-in-asthma-a-systematic-review-and-meta-analysis
#6
John B Hagan, Tanya M Laidlaw, Rohit Divekar, Erin K O'Brien, Hirohito Kita, Gerald W Volcheck, Christina R Hagan, Devyani Lal, Harry G Teaford, Patricia J Erwin, Nan Zhang, Matthew A Rank
BACKGROUND: Urinary leukotriene E4 (ULTE4) may be a biomarker that distinguishes aspirin-intolerant asthma from other asthma subtypes. OBJECTIVE: To estimate the diagnostic testing accuracy of ULTE4 as a marker of aspirin intolerance in patients with asthma using previously published studies. METHODS: We identified relevant clinical studies from a systematic review of English and non-English articles using MEDLINE, EMBASE, and CENTRAL (inception to February 10, 2015)...
February 12, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28197978/managing-cardiovascular-risk-in-lysosomal-acid-lipase-deficiency
#7
REVIEW
James J Maciejko
Lysosomal acid lipase deficiency (LAL-D) is a rare, life-threatening, autosomal recessive, lysosomal storage disease caused by mutations in the LIPA gene, which encodes for lysosomal acid lipase (LAL). This enzyme is necessary for the hydrolysis of cholesteryl ester and triglyceride in lysosomes. Deficient LAL activity causes accumulation of these lipids in lysosomes and a marked decrease in the cytoplasmic free cholesterol concentration, leading to dysfunctional cholesterol homeostasis. The accumulation of neutral lipid occurs predominantly in liver, spleen, and macrophages throughout the body, and the aberrant cholesterol homeostasis causes a marked dyslipidemia...
February 14, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/28196914/the-host-microrna-mir-301a-blocks-the-irf1-mediated-neuronal-innate-immune-response-to-japanese-encephalitis-virus-infection
#8
Bibhabasu Hazra, Kanhaiya Lal Kumawat, Anirban Basu
Effective recognition of viral components and the subsequent stimulation of the production of type I interferons (IFNs) is crucial for the induction of host antiviral immunity. The failure of the host to efficiently produce type I IFNs in response to infection by the Japanese encephalitis virus (JEV) is linked with an increased probability for the disease to become lethal. JEV is a neurotropic virus of the Flaviviridae family that causes encephalitis in humans. JEV infection is regulated by several host factors, including microRNAs, which are conserved noncoding RNAs that participate in various physiological and pathological processes...
February 14, 2017: Science Signaling
https://www.readbyqxmd.com/read/28196532/referral-of-children-seeking-care-at-private-health-facilities-in-uganda
#9
Anthony K Mbonye, Esther Buregyeya, Elizeus Rutebemberwa, Siân E Clarke, Sham Lal, Kristian S Hansen, Pascal Magnussen, Philip LaRussa
BACKGROUND: In Uganda, referral of sick children seeking care at public health facilities is poor and widely reported. However, studies focusing on the private health sector are scanty. The main objective of this study was to assess referral practices for sick children seeking care at private health facilities in order to explore ways of improving treatment and referral of sick children in this sector. METHODS: A survey was conducted from August to October 2014 in Mukono district, central Uganda...
February 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28196502/regional-variation-in-suicide-rates-in-sri-lanka-between-1955-and-2011-a-spatial-and-temporal-analysis
#10
Duleeka W Knipe, Prianka Padmanathan, Lal Muthuwatta, Chris Metcalfe, David Gunnell
BACKGROUND: Between 1955 and 2011 there were marked fluctuations in suicide rates in Sri Lanka; incidence increased six-fold between 1955 and the 1980s, and halved in the early 21st century. Changes in access to highly toxic pesticides are thought to have influenced this pattern. This study investigates variation in suicide rates across Sri Lanka's 25 districts between 1955 and 2011. We hypothesised that changes in the incidence of suicide would be most marked in rural areas due to the variation in availability of highly toxic pesticides in these locations during this time period...
February 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28188322/tennis-ball-sign-a-ct-sign-of-acute-aortic-dissection
#11
REVIEW
Hira Lal, Priyank Yadav, Anand Chellappan, Rajeev Singh
No abstract text is available yet for this article.
February 10, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28187312/glucose-phosphorylated-on-carbon-6-suppresses-lipopolysaccharide-binding-to-lipopolysaccharide-binding-protein-and-inhibits-its-bioactivities
#12
Yuu Fujita, Kiyohito Yagi
Lipid A comprises the active region of lipopolysaccharide (LPS), and its phosphate group is required for LPS activities. Additionally, it is essential for effects of inhibitors of LPS-induced coagulation activity in limulus amebocyte lysate (LAL) tests. Lipid A has phosphorylated glucosamine residues, which are structurally similar to glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P). This study focused on the antagonistic effects of glucose phosphates on the action of protein or non-protein inhibitors against LAL coagulation, LPS-LPS-binding protein (LBP) interaction, and LPS bioactivities...
February 6, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28183653/synthesis-characterization-and-augmented-anticancer-potential-of-peg-betulinic-acid-conjugate
#13
Ankit Saneja, Love Sharma, Ravindra Dhar Dubey, Mubashir Javed Mintoo, Amrinder Singh, Amit Kumar, Payare Lal Sangwan, Sheikh Abdullah Tasaduq, Gurdarshan Singh, Dilip M Mondhe, Prem N Gupta
Betulinic acid (BA), a pentacyclic lupine-type triterpene, is reported to inhibit cell growth in a variety of cancers. However, its efficacy is limited by its poor aqueous solubility and relatively short half-life. In this study, BA-monomethoxy polyethylene glycol (mPEG) conjugate was synthesized by covalent coupling the C-28 carboxylic acid position of BA with amine groups of mPEG, in order to improve its solubility and anticancer efficacy. mPEG-BA conjugate was characterized using various analytical techniques including NMR, FT-IR and MALDI-MS...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28180224/an-open-route-to-asymmetric-substituted-al-al-bonds-using-al-i-and-al-iii-precursors
#14
Bin Li, Subrata Kundu, Hongping Zhu, Helena Keil, Regine Herbst-Irmer, Dietmar Stalke, Gernot Frenking, Diego M Andrada, Herbert W Roesky
The reaction of LAl: (L = HC[C(Me)N(Ar)]2, Ar = 2,6-iPr2C6H3) and cAAC:→AlX3 (X = Cl, I) (cAAC = cyclic alkyl amino carbene) results in strikingly asymmetric Al(ii)-Al(ii) compounds LAl(X)-Al(X)2-cAAC [X = Cl (2a); I (2b)]. In these dialuminum(ii) compounds the two Al atoms bear different ligand environments. For a detailed insight into the structures, theoretical calculations were carried out.
February 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28179703/evaluation-of-five-discriminating-indexes-to-distinguish-beta-thalassemia-trait-from-iron-deficiency-anaemia
#15
Zahid Ullah, Aamer Ali Khattak, Sara Arif Ali, Javaid Hussain, Badshah Noor, Raheela Bano, Muhammad Amin Jan Mahsud
OBJECTIVE: To assess the reliability of different red blood cell indices-based formulae in the indexes formula in differential diagnosis of beta thalassemia trait and iron deficiency anaemia. METHODS: This cross-sectional study was conducted between January and October 2015 in Dera Ismail Khan in the Khyber Pakhtunkhwa province of Pakistan. Patients of beta thalassemia trait and iron deficiency anaemia were registered irrespective of age and gender. About 5 mL of blood was taken from each patient to analyse different red cell parameters like red blood cell count, haemoglobin, mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, and red cell distribution width...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28176443/quantitative-phosphoproteomic-analysis-reveals-system-wide-signaling-pathways-regulated-by-site-specific-phosphorylation-on-keratin-8-in-skin-squamous-cell-carcinoma-derived-cell-line
#16
Richa Tiwari, Indrajit Sahu, Bihari Lal Soni, Gajanan J Sathe, Keshava K Datta, Pankaj Thapa, Shruti Sinha, Chella Krishna Vadivel, Bharti Dhaka, Harsha Gowda, Milind M Vaidya
Keratin 8/18, a simple epithelia specific keratin pair, is often aberrantly expressed in squamous cell carcinomas (SCC) where its expression is correlated with increased invasion and poor prognosis. Majority of Keratin 8 (K8) functions are governed by its phosphorylation at Serine(73) (head-domain) and Serine(431) (tail-domain) residues. Although, deregulation of K8 phosphorylation is associated with progression of different carcinomas, its role in skin-SCC and the underlying mechanism is obscure. In this direction, we performed TMT-based quantitative phosphoproteomics by expressing K8 wild type, phosphodead and phosphomimetic mutants in K8-deficient A431 cells...
February 7, 2017: Proteomics
https://www.readbyqxmd.com/read/28172696/p590-reasons-for-discontinuation-and-switch-of-biologic-therapy-in-ibd-findings-from-a-large-international-observational-study-03
#17
S Sebastian, J D Lewis, B Siegmund, D Wolf, C A Siegel, G Lichtenstein, E Louis, X Hebuterne, P M Ginsburg, A Ostrov, M Q Ricci, M Bernsen, I Shafran, S Nancey, G Moran, N Teich, S Lal, M Kiszka-Kanowitz, S Murugesan, B Moum, P Dolin
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28169259/fluorescence-of-candida-in-diagnosis-of-oral-candidiasis
#18
L R Kumaraswamy Naik, Pushparaja Shetty, M S Krishna Prasad, Vimal Kumar Karnaker, Sarosh E Shroff, Lal P Madathil
BACKGROUND: Many pathogenic fungi fluoresce in hematoxylin and eosin stained sections, and Papanicolaou (PAP)-stained smears under ultraviolet illumination. In theory, this phenomenon could aid in the diagnosis of common fungal infections without the delay which is usually associated with special stains. OBJECTIVE: To evaluate the role of fluorescence as a rapid screening technique for oral infections caused by Candida organisms in exfoliative smears of oral candidiasis...
November 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28166465/isolation-and-characterization-of-large-marine-bacteriophage-myoviridae-vhkm4-infecting-vibrio-harveyi
#19
Tamrin M Lal, Motohiko Sano, Julian Ransangan
The causative agent responsible for vibriosis in tropical fish aquaculture, Vibrio harveyi, has become a major bacterial pathogen. Studies suggest that this bacterium has developed resistance to antibiotics commonly used in aquaculture. In view of this situation and the requirement for the proposed postantibiotic era, bacteriophage therapy seems to be a promising control strategy for fish vibriosis. In this study, a lytic Vibrio phage VhKM4 belonging to a member of large, marine Myoviridae was successfully isolated...
March 2017: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/28165329/role-of-the-local-structure-in-superconductivity-of-lao-_-0-5-f-_-0-5-bis-_-2-x-se-_x-system
#20
Eugenio Paris, Yoshikazu Mizuguchi, Muammer Hacisalihoglu, Takafumi Hiroi, Boby Joseph, Giuliana Aquilanti, Osuke Miura, Takashi Mizokawa, Naurang Lal Saini
We have studied the local structure of LaO$_{0.5}$F$_{0.5}$BiS$_{2-x}$Se$_x$ by Bi L$_1$-edge extended x-ray absorption fine structure (EXAFS). We find a significant effect of Se substitution on the local atomic correlations with a gradual elongation of average in-plane Bi-S bondlength. The associated mean square relative displacement (MSRD), measuring average local distortions in the BiS$_2$ plane, hardly shows any change for small Se-substitution and decreases significantly for x$\ge$0.6. The Se substitution appears to suppress the local distortions within the BiS$_2$ plane that may optimize in-plane orbitals hybridization and hence the superconductivity...
February 6, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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