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https://www.readbyqxmd.com/read/29150048/dna-dependent-protein-kinase-modulates-the-anti-cancer-properties-of-silver-nanoparticles-in-human-cancer-cells
#1
Hui Kheng Lim, Resham Lal Gurung, M Prakash Hande
Silver nanoparticles (Ag-np) were reported to be toxic to eukaryotic cells. These potentially detrimental effects of Ag-np can be advantageous in experimental therapeutics. They are currently being employed to enhance the therapeutic efficacy of cancer drugs. In this study, we demonstrate that Ag-np treatment trigger the activation of DNA-PKcs and JNK pathway at selected doses, presumably as a physiologic response to DNA damage and repair in normal and malignant cells. Ag-np altered the telomere dynamics by disrupting the shelterin complex located at the telomeres and telomere lengths...
December 2017: Mutation Research
https://www.readbyqxmd.com/read/29142979/two-year-follow-up-study-of-membranous-nephropathy-treated-with-tacrolimus-and-corticosteroids-versus-cyclical-corticosteroids-and-cyclophosphamide
#2
Raja Ramachandran, Ashok Kumar Yadav, Vinod Kumar, Venkata Siva Tez Pinnamaneni, Ritambhra Nada, Ratan Ghosh, Vivek Kumar, Manish Rathi, Harbir Singh Kohli, Krishan Lal Gupta, Vinay Sakhuja, Vivekanand Jha
Introduction: Both cCTX/GCs and CNIs are recommended as first-line agents in the management of PMN. The present study is an extended report of patients randomized to receive TAC/GCs or cCTX/GCs at 2 years post randomization. Methods: Seventy patients enrolled in the clinical trial Tacrolimus Combined With Corticosteroids Versus Modified Ponticelli Regimen in Treatment of Idiopathic Membranous Nephropathy: Randomized Control Trial were followed quarterly between 12 and 24 months...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29142563/posterior-occipito-cervical-decompression-with-fixation-and-fusion-in-cranio-vertebral-junction-compression
#3
Lal Rehman, Iram Bokhari, Ali Afzal, Shakeel Ahmad
Objective: To find out the clinical outcome of posterior decompression with occipitocervical fixation and fusion in patients with Craniovertebral junction instability. Methods: Eighty consecutive patients of cranio vertebral junction (CVJ) compression were treated in the department of neurosurgery, Jinnah Postgraduate Medical Centre (JPMC), Karachi over a period of 05 years from 1(st) January 2012 till 31(st) August 2016. All patients underwent posterior decompression with occipitocervical fusion (OCF) and fixation...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29142557/outcome-of-burr-hole-aspiration-of-brain-abscess
#4
Shakeel Ahmad, Lal Rehman, Ali Afzal, Raza Rizvi
Objective: To determine the clinical outcome of burr-hole aspiration of brain abscess. Methods: We analyzed 100 cases of intracranial abscess, treated surgically from January 2015 and October 2016 at Jinnah Postgraduate Medical Centre (JPMC). All patients were treated with burr hole aspiration. Medical records were analyzed for demographics, clinical presentation, predisposing factors, abscess location on imaging and clinical outcomes were charted. Results: The study included 100 patients with 73 (73%) males and 27 (27%) females with a mean age of 36...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29136132/aortic-events-and-reoperations-after-elective-arch-surgery-incidence-surgical-strategies-and-outcomes
#5
Maximilian Luehr, Sven Peterss, Andreas Zierer, Davide Pacini, Christian D Etz, Malakh Lal Shrestha, Konstantinos Tsagakis, Bartosz Rylski, Giampiero Esposito, Klaus Kallenbach, Ruggero De Paulis, Paul P Urbanski
OBJECTIVES: The true incidence of aortic events (AEs) and reoperations (REDO) following elective total aortic arch replacement remains unknown. The aim of this study was to review the incidence of AEs and surgical REDO, and its respective outcomes after 1232 elective arch repairs at 11 European aortic centres. METHODS: Retrospective chart review (in the absence of prospective data collection) was performed for statistical analysis. Follow-up was conducted during routine clinical examination or in a telephone interview with patients and/or their respective physicians...
November 9, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29135844/magnet%C3%A2-enculturation
#6
M Maureen Lal
In this column, the senior manager for the Magnet Appraiser Program® relates the importance of the components of the journey to Magnet with developing and sustaining a culture of excellence through the appraisal period and beyond. Sustainment of excellence includes regular critical assessments and support in nursing practice, governance models, and resources throughout organizational settings where nursing is practiced.
December 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29135395/pattern-and-predictors-of-paradoxical-response-in-patients-with-peripheral-lymph-node-tuberculosis
#7
Supreet Batra, Govind Singh Rajawat, Rajendra Prasad Takhar, Manohar Lal Gupta
Introduction: Many of the patients with lymph node tuberculosis show 'Paradoxical Response" in the form of appearance of new lymph node (LN) or increase in the size of existing LN, development of new disease in other organ and worsening of the disease while on treatment. Reason behind such response in only selective patients is not clearly understood. We evaluated the pattern and predictors for paradoxical response(s) (PR) in patients with peripheral lymph node tuberculosis (TB). Materials and Methods: Study included patients aged > 6 years with peripheral lymphadenopathy of tubercular etiology attending a tertiary care hospital from Jan 2010 to Dec 2010...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29134546/effect-of-hyperbaric-air-on-endotoxin-from-bacteroides-fragilis-strains
#8
Dittmar Chmelař, Adéla Kašíková, Petrana Martineková, Michal Hájek, Miroslav Rozložník, Marek Brabec, Jana Janečková, Jana Vobejdová, Ivan Čižnár
The aim of the project was to determine any effect of hyperbaric air on Bacteroides fragilis strains cultivated under hyperbaric conditions. Previously, it was hypothesized that there was a correlation between the presence of Bacteroides bacteria in patients preferring a meaty diet and cancer of the small intestine, and particularly of the large intestine and rectum. With respect to the fact that Bacteroides fragilis (BAFR) group are important producers of endotoxins, measurement and statistical evaluation of endotoxin production by individual strains of isolated Bacteroides species were used to compare bacteria isolated from various clinical samples from patients with colon and rectum cancer in comparison with strains isolated from other non-cancer diagnoses...
November 13, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/29133663/combined-central-retinal-artery-and-vein-occlusion-with-optic-perineuritis-following-herpes-zoster-dermatitis-in-an-immunocompetent-child
#9
Reema Bansal, Ramandeep Singh, Aastha Takkar, Vivek Lal
A 15-year-old healthy boy developed acute, rapidly progressing visual loss in left eye following herpes zoster dermatitis, with a combined central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO), along with optic perineuritis. Laboratory tests were negative. Despite an empirical, intensive antiviral treatment with systemic corticosteroids, and vision could not be restored in the affected eye. Herpes zoster dermatitis, in an immunocompetent individual, may be associated with a combined CRAO and CRVO along with optic perineuritis, leading to profound visual loss...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29129577/pelvic-bone-anatomy-vs-implanted-gold-seed-marker-registration-for-image-guided-intensity-modulated-radiotherapy-for-prostate-carcinoma-comparative-analysis-of-inter-fraction-motion-and-toxicities
#10
Madhup Rastogi, Sambit Swarup Nanda, Ajeet Kumar Gandhi, Divakar Dalela, Rohini Khurana, Surendra Prasad Mishra, Anoop Srivastava, S Farzana, Madan Lal Brahma Bhatt, Nuzhat Husain
OBJECTIVES: We compared the prostate motion variability and toxicities between patients treated with gold marker registration based IG-IMRT (IG-IMRT-M) and bony landmark registration based IG-IMRT (IG-IMRT-B). METHODS: T1c-T3b (node negative), intermediate and high risk (non-metastatic) adenocarcinoma of prostate, age ≥18years, Karnofsky Performance Status of ≥70 were included in this retrospective study. The prostate motion variability, acute and late radiation toxicities between the two treatment arms (IG-IMRT-M versus IG-IMRT-B) were compared...
November 9, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29126851/ccr6-signaling-inhibits-suppressor-function-of-induced-treg-during-gut-inflammation
#11
Neeraja Kulkarni, Heikrujam Thoihen Meitei, Sandip Ashok Sonar, Praveen Kumar Sharma, Vikkarasan Rehman Mujeeb, Sharad Srivastava, Ramanamurthy Boppana, Girdhari Lal
CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20. The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-chemotaxis functions of CCR6 signaling were not known. Here, we show that during gut inflammation, the frequency of Foxp3(+)CD4(+) T cells (Tregs) reduced in the secondary lymphoid tissues and CCR6(+) Tregs enhanced the expression of RORγt. The peripheral blood mononuclear cells (PBMCs) of ulcerative colitis (UC) patients showed lower percentages of Foxp3(+)CD4(+) T cells, as compared to healthy individuals, with CCR6(+) Tregs showing higher RORγt expression as compared to CCR6(-)Tregs...
November 7, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29126261/heme-promotes-transcriptional-and-demethylase-activities-of-gis1-a-member-of-the-histone-demethylase-jmjd2-kdm4-family
#12
Sneha Lal, Jonathan M Comer, Purna C Konduri, Ajit Shah, Tianyuan Wang, Anthony Lewis, Grant Shoffner, Feng Guo, Li Zhang
The yeast Gis1 protein is a transcriptional regulator belonging to the JMJD2/KDM4 subfamily of demethylases that contain a JmjC domain, which are highly conserved from yeast to humans. They have important functions in histone methylation, cellular signaling and tumorigenesis. Besides serving as a cofactor in many proteins, heme is known to directly regulate the activities of proteins ranging from transcriptional regulators to potassium channels. Here, we report a novel mechanism governing heme regulation of Gis1 transcriptional and histone demethylase activities...
November 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29122351/macroaggregation-and-soil-organic-carbon-restoration-in-a-highly-weathered-brazilian-oxisol-after-two-decades-under-no-till
#13
Ademir de Oliveira Ferreira, João Carlos de Moraes Sá, Rattan Lal, Florent Tivet, Clever Briedis, Thiago Massao Inagaki, Daniel Ruiz Potma Gonçalves, Jucimare Romaniw
Conclusions based on studies of the impacts of soil organic carbon (SOC) fractions and soil texture on macroaggregation and SOC stabilization in long-term (>20years) no-till (NT) fields remain debatable. This study was based on the hypothesis that the amount and frequency of biomass-C input associated with NT can be a pathway to formation of macroaggregates and to SOC buildup. The objectives were to: 1) assess the macroaggregate distribution (proportional mass, class mass) and the SOC and particulate organic carbon (POC) stocks of extra-large (8-19mm), large (2-8mm) and small (0...
November 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29122081/gender-specific-differences-in-serum-immunoglobulin-e-levels-and-prevalence-of-fungus-in-sinonasal-tissue-noted-in-patients-with-chronic-rhinosinusitis-who-underwent-endoscopic-sinus-surgery
#14
Antoine Azar, Matthew A Rank, Matthew A Zarka, Yu-Hui Chang, Devyani Lal
BACKGROUND: We previously presented that women with chronic rhinosinusitis (CRS) who elected endoscopic sinus surgery (ESS) have a higher symptom burden than men. Causes of these gender-based differences warranted further study. OBJECTIVES: To study gender differences in another cohort of adult patients with CRS who underwent ESS and to compare key histopathologic and serologic features Methods: Patients with CRS who underwent ESS (from 2011 to 2014) with structured histopathology reports on surgical samples were studied...
November 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29121777/treatment-and-prognostic-factors-of-patients-with-thymic-epithelial-tumors-at-first-recurrence-or-progression
#15
Giuseppe L Banna, Ankur Sheel, Varun Sheel, Andrea Bille, Tom Routledge, Shalini Fernando, Arjun Nair, Rohit Lal
AIM: The treatment of patients with recurrent or progressive thymic epithelial tumors remains uncertain due to limited data in this rare disease. MATERIALS & METHODS: A retrospective 10-year monoinstitutional analysis was conducted on 25 patients with first recurrence or disease progression following primary treatment. RESULTS: Twenty patients had thymoma, five thymic carcinomas. Ten patients (40%) received surgery, four (40%) following chemotherapy; 17 (68%) had chemotherapy, with a combination regimen in 16 of them (94%)...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29121768/comparative-analysis-of-tocopherol-biosynthesis-genes-and-its-transcriptional-regulation-in-soybean-seeds
#16
Vinutha T, Navita Bansal, Khushboo Kumari, Rama Prashat G, Rohini Sreevathsa, Veda Krishnan, Sweta Kumari, Anil Dahuja, S K Lal, Archana Sachdev, Shelly Praveen
Tocopherols composed of four isoforms (α, β, γ and δ) and its biosynthesis comprises of three pathways; Methylerythritol 4-phosphate (MEP), shikimate (SK) and tocopherol-core pathways regulated by 25 enzymes. To understand pathway regulatory mechanism at transcriptional level, gene expression profile of tocopherol-biosynthesis genes in two soybean genotypes was carried out, the results showed significantly differential expression of 5 genes; 1-deoxy-D-xylulose-5-P-reductoisomerase (DXR), geranyl geranyl reductase (GGDR)¬ - from MEP; arogenate dehydrogenase (TyrA), tyrosine aminotransferase (TAT) - from SK and γ-tocopherol methyl transferase 3 (γ-TMT3) from tocopherol-core pathways...
November 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29120170/cationic-ti-complexes-with-three-n-o-type-tetrazolyl-ligands-ti%C3%A2-fe-transmetalation-within-fe-metallascorpionate-complexes
#17
Yu Jin Park, Ji Yeon Ryu, Sam Hwang, Ka Hyun Park, Ji Min Lee, Sung Cho, Sunwoo Lee, Manik Lal Saha, Peter J Stang, Junseong Lee
Herein, we report the synthesis of two novel ionic Ti complexes possessing three [N,O]-type bidentate ligands from the reaction of Fe metallascorpionate ligands possessing extended alcohol groups and TiCl4. The reaction of substituted hydroxyphenyl tetrazole and Fe(ClO4)3 in a molar ratio of 3:1 afforded iron scorpionate metalloligands possessing extended arms, which were characterized by IR spectroscopy and ESI-TOF-MS spectrometry. Their molecular structures were also confirmed as neutral Fe-centered scorpionate complexes by X-ray crystallography, in which the extended alcohol groups adopted a tripodal geometry...
November 9, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29118489/minimal-duration-cataract-surgery-with-oblique-limbal-stab-incision-technique
#18
Deepti Mahajan, Ram Lal Sharma, Kulbhushan Prakash Chaudhary
PURPOSE: Small incision cataract surgery (SICS) and phacoemulsification with oblique limbal stab incision technique were studied and compared. SETTING: The study was conducted in the Department of Ophthalmology, Indira Gandhi Medical College, Shimla, for 1 year. DESIGN: This was a prospective randomized study. METHODS: One hundred patients undergoing SICS (6-7 mm) were compared with another age- and sex-matched 100 patients undergoing phaco (2...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29115881/a-review-of-current-and-developing-fixed-dose-laba-lama-combinations-for-treating-copd
#19
Chitra Lal, Charlie Strange
The current GOLD (Global Initiative for Chronic Obstructive Lung Disease) recommendations suggest using long acting β2 agonists (LABA) and long acting muscarinic antagonists (LAMA) in combination for group B COPD patients with persistent symptoms, group C COPD patients with further exacerbations on LAMA therapy alone and for group D COPD patients with or without combination with inhaled corticosteroids (ICS). Thus, there is a lot of interest in developing LABA/LAMA combinations for maintenance therapy of chronic stable COPD...
November 8, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29115034/heart-failure-admissions-and-poor-subsequent-outcomes-in-adults-with-congenital-heart-disease
#20
Sean Lal, Irina Kotchetkova, Jacob Cao, Daniel Jackson, Rachael Cordina, David S Celermajer
No abstract text is available yet for this article.
November 7, 2017: European Journal of Heart Failure
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