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https://www.readbyqxmd.com/read/29773794/calreticulin-and-integrin-alpha-dissociation-induces-anti-inflammatory-programming-in-animal-models-of-inflammatory-bowel-disease
#1
Masayoshi Ohkuro, Jun-Dal Kim, Yoshikazu Kuboi, Yuki Hayashi, Hayase Mizukami, Hiroko Kobayashi-Kuramochi, Kenzo Muramoto, Manabu Shirato, Fumiko Michikawa-Tanaka, Jun Moriya, Teruya Kozaki, Kazuma Takase, Kenichi Chiba, Kishan Lal Agarwala, Takayuki Kimura, Makoto Kotake, Tetsuya Kawahara, Naoki Yoneda, Shinsuke Hirota, Hiroshi Azuma, Nobuko Ozasa-Komura, Yoshiaki Ohashi, Masafumi Muratani, Keiji Kimura, Ieharu Hishinuma, Akiyoshi Fukamizu
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a chronic intestinal inflammatory condition initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Calreticulin (CRT), a calcium-binding chaperone, is known as a partner in the activation of integrin α subunits (ITGAs). The relationship between their interaction and the pathogenesis of IBD is largely unknown. Here we show that a small molecule, orally active ER-464195-01, inhibits the CRT binding to ITGAs, which suppresses the adhesiveness of both T cells and neutrophils...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29773783/cholesteryl-ester-storage-disease-fatal-outcome-without-causal-therapy-in-a-female-patient-with-the-preventable-sequelae-of-progressive-liver-disease-after-many-years-of-mild-symptoms
#2
Ali Canbay, Meike N Müller, Stathis Philippou, Guido Gerken, Andreas Tromm
BACKGROUND Cholesteryl ester storage disease (CESD), also known as lysosomal acid lipase deficiency (LAL-D), is a rare autosomal-recessive inheritable lysosomal storage disease. Since 2015, a causal treatment with sebelipase alfa, which replaces the missing LAL enzyme, has been approved. We report a fatal course of LAL-D in a female patient. CASE REPORT In 1979, CESD was first diagnosed in a 13-year-old female with marked hepatomegaly. At that time, no specific treatment for CESD was available and the spontaneous course of the disease had to be awaited...
May 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29770696/structural-characterization-of-b-site-ordered-ba-2-ln-2-3-teo-6-ln-la-pr-nd-sm-and-eu-double-perovskites-and-probing-its-luminescence-as-eu-3-phosphor-hosts
#3
Sariga C Lal, Vidhya Lalan, Subodh Ganesanpotti
Ba2 Ln2/3 TeO6 (Ln = La, Pr, Nd, Sm, and Eu) double perovskites were synthesized via solid-state ceramic route. Preliminary X-ray diffraction studies indicated a pseudocubic structure with lattice parameters ranging from 8.55 to 8.44 Å for the substitution of rare earths from La to Eu. Raman spectra show the frequency dependence of various Raman bands with respect to rare-earth substitution and exhibit a significant shift in peaks to higher wavenumber region, which was observed only for symmetric stretching modes of LnO6 and TeO6 octahedra...
May 17, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29770263/evaluation-of-quantitative-and-qualitative-renal-outcome-following-nephron-sparing-surgery
#4
Gautam Ram Choudhary, Arup Kumar Mandal, Uttam Mete, Ravimohan Mavuduru, Anish Bhatacharia, Anupam Lal, Suresh Goyal
Purpose: Preservation of renal function after nephron-sparing surgery (NSS) is multifactorial and the impact of individual factors on it is still a debate. This prospective study investigates the impact of factors responsible for quantitative and functional outcome after NSS. Patients and Methods: Fifty-two patients of localized renal mass (≤7 cm) were included in the study. A contrast-enhanced computed tomography abdomen was performed for characterization of tumor...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29770126/crosstalk-between-the-unfolded-protein-response-micrornas-and-insulin-signaling-pathways-in-search-of-biomarkers-for-the-diagnosis-and-treatment-of-type-2-diabetes
#5
REVIEW
Chinar Berry, Megha Lal, B K Binukumar
Type 2 diabetes mellitus (T2DM) is a metabolic disorder that is characterized by functional defects in glucose metabolism and insulin secretion. Its complex etiology and multifaceted nature have made it difficult to design effective therapies for early diagnosis and treatment. Several lines of evidence indicate that aberrant activation of the unfolded protein response (UPR) in response to endoplasmic reticulum (ER) stress impairs the β cell's ability to respond to glucose and promotes apoptosis. Elucidating the molecular mechanisms that govern β cell dysfunction and cell death can help investigators design therapies to halt or prevent the development of T2DM...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29767973/discovery-of-orally-bioavailable-quinoline-based-aldehyde-dehydrogenase-1a1-aldh1a1-inhibitors-with-potent-cellular-activity
#6
Shyh-Ming Yang, Natalia J Martinez, Adam Yasgar, Carina Danchik, Catrine Johansson, Yuhong Wang, Bolormaa Baljinnyam, Amy Q Wang, Xin Xu, Pranav Shah, Dorian Cheff, Xinran S Wang, Jacob Roth, Madhu Lal-Nag, James Edward Dunford, Udo C T Oppermann, Vasilis Vasiliou, Anton Simeonov, Ajit Jadhav, David J Maloney
Aldehyde dehydrogenases (ALDHs) are responsible for the metabolism of aldehydes (exogenous and endogenous) and possess vital physiological and toxicological functions in areas such as CNS, inflammation, metabolic disorders, and cancers. Overexpression of certain ALDHs (e.g. ALDH1A1) are important biomarkers in cancers and cancer stem cells (CSCs) indicating the potential need for the identification and development of small molecule ALDH inhibitors. Herein, a newly designed series of quinoline-based analogs of ALDH1A1 inhibitors is described...
May 16, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29766973/large-serpentine-aneurysm-of-the-anterior-cerebral-artery
#7
Amith S Kumar, Julie Sachdeva, Neeraj Balaini, Ritu Shree, Manoj K Goyal, Vivek Lal, Chirag Ahuja
No abstract text is available yet for this article.
May 2018: Neurology India
https://www.readbyqxmd.com/read/29765828/a-cross-sectional-survey-of-the-north-american-skull-base-society-on-vestibular-schwannoma-part-2-perioperative-practice-patterns-of-vestibular-schwannoma-in-north-america
#8
Jamie J Van Gompel, Matthew L Carlson, R Mark Wiet, Nicole M Tombers, Anand K Devaiah M, Devyani Lal, Jacques J Morcos, Michael J Link
Introduction  Perioperative care of vestibular schwannoma (VS) patients is extremely variable across surgeons and institutions making practice patterns difficult to standardize. No data currently exist detailing this practice variability. Methods  The North American Skull Base Society membership was electronically surveyed regarding perioperative care of surgically operated VS patients. Results  There were 87 respondents to the survey. Surgical positioning, surgical approach utilized, and perioperative medical adjuncts are quite variable...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29765827/a-cross-sectional-survey-of-the-north-american-skull-base-society-current-practice-patterns-of-vestibular-schwannoma-evaluation-and-management-in-north-america
#9
Matthew L Carlson, Jamie J Van Gompel, R Mark Wiet, Nicole M Tombers, Anand K Devaiah, Devyani Lal, Jacques J Morcos, Michael J Link
Background  Very few studies have examined vestibular schwannoma (VS) management trends across centers and between providers. The objective of this study is to examine current practice trends, variance in treatment philosophies, and nuanced or controversial aspects of VS care across North America. Methods  This is a cross-sectional survey of North American Skull Base Society (NASBS) members who report regular involvement in VS care. Results  A total of 57 completed surveys were returned. Most respondents claimed to have over 20 years of experience and the majority reported working in an academic practice with an affiliated otolaryngology and/or neurosurgery residency program...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29765477/detecting-epileptic-seizure-with-different-feature-extracting-strategies-using-robust-machine-learning-classification-techniques-by-applying-advance-parameter-optimization-approach
#10
Lal Hussain
Epilepsy is a neurological disorder produced due to abnormal excitability of neurons in the brain. The research reveals that brain activity is monitored through electroencephalogram (EEG) of patients suffered from seizure to detect the epileptic seizure. The performance of EEG detection based epilepsy require feature extracting strategies. In this research, we have extracted varying features extracting strategies based on time and frequency domain characteristics, nonlinear, wavelet based entropy and few statistical features...
June 2018: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29765464/renin-angiotensin-aldosterone-inhibition-improves-right-ventricular-function-a-meta-analysis
#11
REVIEW
Jacob Y Cao, Seung Yeon Lee, Kevin Phan, David S Celermajer, Sean Lal
The benefits of inhibiting the renin-angiotensin-aldosterone system (RAAS) are well established for left ventricular dysfunction, but remain unknown for right ventricular (RV) dysfunction. The aim of the current meta-analysis is to investigate the role of RAAS inhibition on RV function in those with or at risk of RV dysfunction. Medline, PubMed, EMBASE and Cochrane Libraries were systematically searched and 12 studies were included for statistical synthesis, comprising 265 RAAS inhibition treatment patients and 265 placebo control patients...
2018: Heart Asia
https://www.readbyqxmd.com/read/29765153/cox-2-mediates-pro-tumorigenic-effects-of-pkc%C3%AE%C2%B5-in-prostate-cancer
#12
Rachana Garg, Jorge M Blando, Carlos J Perez, Priti Lal, Michael D Feldman, Emer M Smyth, Emanuela Ricciotti, Tilo Grosser, Fernando Benavides, Marcelo G Kazanietz
The pro-oncogenic kinase PKCε is overexpressed in human prostate cancer and cooperates with loss of the tumor suppressor Pten for the development of prostatic adenocarcinoma. However, the effectors driving PKCε-mediated phenotypes remain poorly defined. Here, using cellular and mouse models, we showed that PKCε overexpression acts synergistically with Pten loss to promote NF-κB activation and induce cyclooxygenase-2 (COX-2) expression, phenotypic traits which are also observed in human prostate tumors. Targeted disruption of PKCε from prostate cancer cells impaired COX-2 induction and PGE2 production...
May 16, 2018: Oncogene
https://www.readbyqxmd.com/read/29762517/the-potential-cost-effectiveness-and-equity-impacts-of-restricting-television-advertising-of-unhealthy-food-and-beverages-to-australian-children
#13
Vicki Brown, Jaithri Ananthapavan, Lennert Veerman, Gary Sacks, Anita Lal, Anna Peeters, Kathryn Backholer, Marjory Moodie
Television (TV) advertising of food and beverages high in fat, sugar and salt (HFSS) influences food preferences and consumption. Children from lower socioeconomic position (SEP) have higher exposure to TV advertising due to more time spent watching TV. This paper sought to estimate the cost-effectiveness of legislation to restrict HFSS TV advertising until 9:30 pm, and to examine how health benefits and healthcare cost-savings differ by SEP. Cost-effectiveness modelling was undertaken (i) at the population level, and (ii) by area-level SEP...
May 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29756005/peripheral-lymph-node-excisional-biopsy-yield-relevance-and-outcomes-in-a-remote-surgical-setup
#14
Ashish Lal Shrestha, Pradita Shrestha
Objective: To study the patient profile for symptomatic peripheral lymphadenopathy in terms of histopathological findings and demography and evaluate the yield, relevance, and outcomes of peripheral lymph node biopsy (PLNB) as a diagnostic step in a remote setup in the absence of less invasive options like fine-needle aspiration cytology (FNAC) or ultrasonogram- (USG-) guided FNAC. Methods: A retrospective review of patients undergoing PLNB between 1 May 2011 and 30 April 2013 was done...
2018: Surgery Research and Practice
https://www.readbyqxmd.com/read/29754785/prognostic-factors-including-lymphovascular-invasion-on-survival-for-resected-non-small-cell-lung-cancer
#15
Lawrence Okiror, Leanne Harling, Levon Toufektzian, Juliet King, Tom Routledge, Karen Harrison-Phipps, John Pilling, Lukacs Veres, Ruchi Lal, Andrea Bille
OBJECTIVES: The aim of this study was to report on the influence of tumor lymphovascular invasion on overall survival and in patients with resected non-small cell lung cancer and identify prognostic factors for survival. METHODS: This is a retrospective observational study of a consecutive series of patients who had surgical resection of non-small cell lung cancer in a single institution. The study covers a 3-year period. Overall survival was estimated by Kaplan-Meier method and multivariate Cox regression analysis was used to evaluate the relationship of lymphovascular invasion and other clinicopathologic variables...
April 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29753026/chronic-hyperinsulinemia-promotes-meta-inflammation-and-extracellular-matrix-deposition-in-adipose-tissue-implications-of-nitric-oxide
#16
Durgesh Kumar, Kripa Shankar, Saraswati Patel, Abhishek Gupta, Salil Varshney, Sanchita Gupta, Sujith Rajan, Ankita Srivastava, Achchhe Lal Vishwakarma, Anil N Gaikwad
Various imperative studies support the notion that hyperinsulinemia (HI) itself serves as the common link between adipose tissue inflammation (ATI) and metabolic syndrome. However, the contribution of HI mediated ATI and its metabolic consequences are yet to be explored. We induced chronic HI per se in mice by administration of exogenous insulin for 8 weeks through mini-osmotic pumps. For the reduction of circulating insulin in response to excess calorie intake, we have partially ablated β-cells by using streptozotocin (STZ) in the diet-induced obesity (DIO) and genetic mice models (db/db)...
May 9, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29751891/a-bayesian-spatio-temporal-framework-to-identify-outbreaks-and-examine-environmental-and-social-risk-factors-for-infectious-diseases-monitored-by-routine-surveillance
#17
Aparna Lal, Jonathan Marshall, Jackie Benschop, Aleisha Brock, Simon Hales, Michael G Baker, Nigel P French
Spatio-temporal disease patterns can provide clues to etiological pathways, but can be complex to model. Using a flexible Bayesian hierarchical framework, we identify previously undetected space-time clusters and environmental and socio-demographic risk factors for reported giardiasis and cryptosporidiosis at the New Zealand small area level. For giardiasis, there was no seasonal pattern in outbreak probability and an inverse association with density of dairy cattle (β^1  = -0.09, Incidence Risk Ratio (IRR) 0...
June 2018: Spatial and Spatio-temporal Epidemiology
https://www.readbyqxmd.com/read/29751233/new-developments-in-non-quinolone-based-antibiotics-for-the-inhibiton-of-bacterial-gyrase-and-topoisomerase-iv
#18
REVIEW
Syed Lal Badshah, Asad Ullah
The inhibition of pathogenic bacteria at the replication stage is important to halt their further reproduction and spread. The replication enzymes include the DNA gyrase and topoisomerase IV that are recognized targets for the infection control. Novel antibiotic compounds are always in demand for targeting different active sites of these enzymes. Although quinolones are the current drug of choice for targeting these enzymes, emerging resistance is a global concern. Wide-scale efforts are needed to overcome the emerging resistance by designing more potent drugs...
May 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29746120/formation-of-mono-and-polynuclear-luminescent-lanthanide-complexes-based-on-the-coordination-of-preorganized-phosphonated-pyridines
#19
Jérémy Salaam, Lilia Tabti, Sylvana Bahamyirou, Alexandre Lecointre, Oscar Hernandez Alba, Olivier Jeannin, Franck Camerel, Sarah Cianférani, Embarek Bentouhami, Aline M Nonat, Loïc J Charbonnière
A series of polynuclear assemblies based on ligand L (1,4,7-tris[hydrogen (6-methylpyridin-2-yl)phosphonate]-1,4,7-triazacyclononane) has been developed. The coordination properties of ligand L with LnIII (Ln = La, Eu, Tb, Yb, Lu) have been studied in water (pH = 7.0) and in D2 O (pD = 7.0) by UV-absorption spectrometry, spectrofluorimetry, 1 H and 31 P NMR, DOSY, ESI-mass spectrometry, and X-ray diffraction. This nonadentate ligand forms highly stable mononuclear complexes in water and provides a very efficient shielding of the Ln cations, as emphasized by the very good luminescence properties of the Yb complex in D2 O, especially regarding its lifetime (τD2 O = 10...
May 10, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29744933/internal-migrants-experiences-with-and-perceptions-of-frontline-health-workers-a-nationwide-study-in-13-indian-cities
#20
Bontha V Babu, Yogita Sharma, Yadlapalli S Kusuma, Muthusamy Sivakami, Dharmesh K Lal, Palaniappan Marimuthu, Jagjeevan B Geddam, Anoop Khanna, Monika Agarwal, Godi Sudhakar, Paramita Sengupta, Anjali Borhade, Zulfia Khan, Anna S Kerketta, Akoijam Brogen
The role of frontline health workers is crucial in strengthening primary health care in India. This paper reports on the extent of services provided by frontline health workers in migrants' experiences and perceptions of these services in 13 Indian cities. Cluster random sampling was used to sample 51 055 households for a quantitative survey through interviewer-administered questionnaires. Information was sought on the receipt of health workers' services for general health care overall (from the head/other adult member of the household) and maternal and immunization services in particular (from mothers of children <2 years old)...
May 9, 2018: International Journal of Health Planning and Management
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