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https://www.readbyqxmd.com/read/29440040/objectively-measured-physical-activity-sedentary-behaviour-and-all-cause-mortality-in-older-men-does-volume-of-activity-matter-more-than-pattern-of-accumulation
#1
Barbara J Jefferis, Tessa J Parsons, Claudio Sartini, Sarah Ash, Lucy T Lennon, Olia Papacosta, Richard W Morris, S Goya Wannamethee, I-Min Lee, Peter H Whincup
OBJECTIVES: To understand how device-measured sedentary behaviour and physical activity are related to all-cause mortality in older men, an age group with high levels of inactivity and sedentary behaviour. METHODS: Prospective population-based cohort study of men recruited from 24 UK General Practices in 1978-1980. In 2010-2012, 3137 surviving men were invited to a follow-up, 1655 (aged 71-92 years) agreed. Nurses measured height and weight, men completed health and demographic questionnaires and wore an ActiGraph GT3x accelerometer...
February 12, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29433017/continuing-global-improvement-in-human-papillomavirus-dna-genotyping-services-the-2013-and-2014-hpv-labnet-international-proficiency-studies
#2
Carina Eklund, Ola Forslund, Keng-Ling Wallin, Joakim Dillner
BACKGROUND: Accurate and internationally comparable human papillomavirus (HPV) DNA detection and typing services are essential for HPV vaccine research and surveillance. OBJECTIVES: This study assessed the proficiency of different HPV typing services offered routinely in laboratories worldwide. STUDY DESIGN: The HPV Laboratory Network (LabNet) has designed international proficiency panels that can be regularly issued. The HPV genotyping proficiency panels of 2013 and 2014 contained 43 and 41 coded samples, respectively, composed of purified plasmids of sixteen HPV types (HPV 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68a and 68b) and 3 extraction controls...
February 9, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29428399/comparison-of-cobas-hcv-gt-against-versant-hcv-genotype-2-0-lipa-with-confirmation-by-sanger-sequencing
#3
Falah Yusrina, Cui Wen Chua, Chun Kiat Lee, Lily Chiu, Tracy Si-Yu Png, Mui Joo Khoo, Gabriel Yan, Guan Huei Lee, Benedict Yan, Hong Kai Lee
BACKGROUND: Correct identification of infecting hepatitis C virus (HCV) genotype is helpful for targeted antiviral therapy. OBJECTIVES: Here, we compared the HCV genotyping performance of the cobas HCV GT assay against the Versant HCV Genotype 2.0 (LiPA) assay, using 97 archived serum samples. STUDY DESIGN: In the event of discrepant or indeterminate results produced by either assay, the core and NS5B regions were sequenced. RESULTS: Of the 97 samples tested by the cobas, 25 (26%) were deemed indeterminate...
February 8, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29366243/targeted-sequencing-of-apoc3-gckr-lipa-ppp1r3b-ncan-lyplal1-and-tm6sf2-genes-in-patients-with-nonalcoholic-fatty-liver-disease-nafld
#4
Alessia Di Costanzo, Francesca Belardinilli, Diego Bailetti, Marialuisa Sponziello, Laura D'Erasmo, Licia Polimeni, Francesco Baratta, Maria Del Ben, Giuseppe Giannini, Francesco Angelico, Marcello Arca
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29366166/lysosomal-acid-lipase-deficiency-diagnostics-and-mutation-spectrum-of-lipa-gene-in-cohort-of-patients-with-hypercolesterolemia
#5
Ekaterina Zakharova, Elena Kamenets, Galina Baydakova, Svetlana Mikhaylova, Tatiana Strokova, Madlena Bagaeva, Alla Lavrova, Maria Amelina, Natalia Pichkur
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29366092/common-functional-variant-lipa-t16p-affects-hdl-composition-among-patients-with-heterozygous-familial-hypercholesterolemia
#6
Atushi Nohara, Masa-Aki Kawashiri, Yoshikatsu Eto, Miwa Fujisaki, Hayato Tada, Mie Yoshida, Mika Mori, Chiaki Nakanishi, Kunimasa Yagi, Akihiro Inazu, Masakazu Yamagishi, Hiroshi Mabuchi
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29343824/human-papillomavirus-prophylactic-vaccination-improves-reproductive-outcome-in-infertile-patients-with-hpv-semen-infection-a-retrospective-study
#7
Andrea Garolla, Luca De Toni, Alberto Bottacin, Umberto Valente, Maurizio De Rocco Ponce, Andrea Di Nisio, Carlo Foresta
In this study we aimed to evaluate the effect on reproductive outcome of HPV vaccination in male subjects of infertile couples with HPV semen infection. In this single-center study, we retrospectively enrolled 151 infertile couples with detection of HPV in semen, attending our Hospital Unit of Andrology between January 2013 and June 2015, counseled to receive adjuvant HPV vaccination. Seventy-nine accepted vaccination (vaccine group) whilst 72 did not (control group). Our protocol of follow-up, aimed to evaluate HPV viral clearance, consisted in semen analysis, INNO-LiPA and FISH for HPV in semen cells after 6 and 12 months from basal evaluation...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335837/backbone-chemical-shift-assignments-of-the-glycine-cleavage-complex-h-protein-of-escherichia-coli
#8
Usha Yadav, Monica Sundd
Glycine cleavage complex H protein (GcvH) is one of the four components that form the glycine cleavage complex (GCS), essential for the synthesis of C1 (one-carbon units) for cell metabolism, by the oxidative cleavage of glycine. The activity of this complex is induced in the presence of exogenous glycine, and is repressed by purines. GCS, in cooperation with GCA (serine hydroxymethyltransferase) regulates the endogenous levels of glycine and C1 units in the cell. GcvH, the lipoamide containing component of the complex, plays an indispensable role in this reaction, as its prosthetic group shuttles between the active site of the three other components of the GCS complex sequentially...
January 15, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29334901/monitoring-vaccine-and-non-vaccine-hpv-type-prevalence-in-the-post-vaccination-era-in-women-living-in-the-basilicata-region-italy
#9
Francesca Carozzi, Donella Puliti, Cristina Ocello, Pasquale Silvio Anastasio, Espedito Antonio Moliterni, Emilia Perinetti, Laurence Serradell, Elena Burroni, Massimo Confortini, Paola Mantellini, Marco Zappa, Géraldine Dominiak-Felden
BACKGROUND: A large free-of-charge quadrivalent HPV (qHPV) vaccination program, covering four cohorts annually (women 11, 14, 17 and 24 years), has been implemented in Basilicata since 2007. This study evaluated vaccine and non-vaccine HPV prevalence 5-7 years post-vaccination program implementation in vaccinated and unvaccinated women. METHODS: This population-based, cross-sectional study was conducted in the public screening centers of the Local Health Unit in Matera between 2012 and 2014...
January 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29332587/lysosomal-acid-lipase-deficiency-could-dyslipidemia-drive-the-diagnosis
#10
Ornella Guardamagna, Federica Guaraldi
LAL-deficiency (LAL-D) is a rare and systemic condition, secondary to LIPA gene mutations, responsible for lysosomal accumulation of cholesteryl esters and triglycerides, whose manifestations are very heterogeneous in terms of age of onset, severity and type of clinical and radiological manifestations. Dyslipidemia, hepatomegaly and hepatosteatosis with increased levels of transaminases are the most common features. The increased risk of premature atherosclerosis and cardiovascular disorders,, secondary to a generalized alteration of lipid profile and lipoprotein dysfunction associated with LAL-D, has been increasingly pointed out...
January 11, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29310947/sanger-sequencing-versus-inno-lipa%C3%A2-hbv-precore-assay-for-routine-detection-of-precore-and-basal-core-promoter-mutations-in-hepatitis-virus-b-chronically-infected-patients
#11
E K Alidjinou, L Bocket, V Pigot, V Lambert, C Hallaert, V Canva, D Hober
We compared the Sanger sequencing and the commercial INNO-LiPA® HBV assay for the routine detection of precore (PC) and basal core promoter (BCP) mutations of hepatitis B virus in chronically infected patients. The overall agreement rate between assays was 94.2% and 98.8% for the detection of PC and BCP mutations, respectively.
December 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29302509/a-novel-homozygous-lipa-mutation-in-a-korean-child-with-lysosomal-acid-lipase-deficiency
#12
Kwang Yeon Kim, Ju Whi Kim, Kyung Jae Lee, Eunhyang Park, Gyeong Hoon Kang, Young Hun Choi, Woo Sun Kim, Jung Min Ko, Jin Soo Moon, Jae Sung Ko
Patients with lysosomal acid lipase (LAL) deficiency and glycogen storage disease (GSD) demonstrated hepatomegaly and dyslipidemia. In our case, a 6-year-old boy presented with hepatosplenomegaly. At 3 years of age, GSD had been diagnosed by liver biopsy at another hospital. He showed elevated serum liver enzymes and dyslipidemia. Liver biopsy revealed diffuse microvesicular fatty changes in hepatocytes, septal fibrosis and foamy macrophages. Ultrastructural examination demonstrated numerous lysosomes that contained lipid material and intracytoplasmic cholesterol clefts...
December 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29286606/human-papilloma-virus-genotype-distribution-in-cervical-lesions-in-zanjan-iran
#13
Shahrzad Ahmadi, Hossein Goudarzi, Ahmad Jalilvand, Abdolreza Esmaeilzadeh
Objective: Cervical cancer is one of the most common cancers among women all over the world, and main cause is persistent infection with high risk human papillomavirus (HPV) strains. It has been reported that the distribution and prevalence of HPV types varies by geographical region, so that this is important for prevention by type-specific vaccines. The aim of current study was to determine the genotype distribution of HPV using the INNO-LiPA genotyping assay in Zanjan province, North West Iran. Methods: A total of 112 formalin-fixed paraffin embedded (FFPE) tissue samples from cases of low-grade intraepithelial lesion (LSIL), high-grade intraepithelial lesion (HSIL) and squamous cell carcinoma (SCC) were collected...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29281779/inhibition-of-autolysis-by-lipase-lipa-in-streptococcus-pneumoniae-sepsis
#14
Gyu-Lee Kim, Truc Thanh Luong, Sang-Sang Park, Seungyeop Lee, Jung Ah Ha, Cuong Thach Nguyen, Ji Hye Ahn, Ki-Tae Park, Man-Jeong Paik, Suhkneung Pyo, David E Briles, Dong-Kwon Rhee
More than 50% of sepsis cases are associated with pneumonia. Sepsis is caused by infiltration of bacteria into the blood via inflammation, which is triggered by the release of cell wall components following lysis. However, the regulatory mechanism of lysis during infection is not well defined. Mice were infected with Streptococcus pneumoniae D39 wild-type (WT) and lipase mutant (ΔlipA) intranasally (pneumonia model) or intraperitoneally (sepsis model), and survival rate and pneumococcal colonization were determined...
December 26, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29246491/impact-of-loss-of-soat2-function-on-disease-progression-in-the-lysosomal-acid-lipase-deficient-mouse
#15
Adam M Lopez, Jen-Chieh Chuang, Stephen D Turley
Although only a small proportion of cholesterol in the body is esterified, in several diseases marked expansion of the esterified cholesterol (EC) pool occurs. These include Wolman disease (WD) and Cholesteryl Ester Storage Disease (CESD) which both result from mutations in LIPA, the gene that encodes lysosomal acid lipase (LAL). The respective contributions that our three cholesterol esterifying enzymes make to EC production, especially in disorders like CESD, are not well defined. The current studies represent a detailed exploration of our earlier findings in young male LAL-deficient mice also missing sterol-O-acyltransferase 2 (SOAT2, also called ACAT2)...
December 12, 2017: Steroids
https://www.readbyqxmd.com/read/29244767/regulatory-elements-located-in-the-upstream-region-of-the-rhizobium-leguminosarum-rosr-global-regulator-are-essential-for-its-transcription-and-mrna-stability
#16
Kamila Rachwał, Paulina Lipa, Iwona Wojda, José-María Vinardell, Monika Janczarek
Rhizobium leguminosarum bv. trifolii is a soil bacterium capable of establishing a symbiotic relationship with clover (Trifolium spp.). Previously, the rosR gene, encoding a global regulatory protein involved in motility, synthesis of cell-surface components, and other cellular processes was identified and characterized in this bacterium. This gene possesses a long upstream region that contains several regulatory motifs, including inverted repeats (IRs) of different lengths. So far, the role of these motifs in the regulation of rosR transcription has not been elucidated in detail...
December 15, 2017: Genes
https://www.readbyqxmd.com/read/29234937/-lysosomal-acid-lipase-deficiency-lal-d-diagnostic-and-therapeutic-options-in-an-underdiagnosed-disease
#17
REVIEW
S Synoracki, S Kathemann, K W Schmid, H Jastrow, H A Baba
BACKGROUND AND CLINICAL SETTING: Lysosomal acid lipase deficiency is an autosomal recessive storage disease caused by mutations in the LIPA gene. The accumulation of cholesteryl esters and triglycerides in hepatocytes lead to hepatomegaly with progressive fibrosis and liver cirrhosis. Characteristically, patients have a hepatomegaly combined with high serum levels of cholesterol, LDL-cholesterol and in some cases triglyceride, whereas HDL-cholesterol is decreased. Histologically, hepatocytes show a microvesicular steatosis with typically ballooned Kupffer cells...
December 12, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29214758/comparison-of-four-human-papillomavirus-genotyping-methods-next-generation-sequencing-inno-lipa-electrochemical-dna-chip-and-nested-pcr
#18
Pornjarim Nilyanimit, Jira Chansaenroj, Witthaya Poomipak, Kesmanee Praianantathavorn, Sunchai Payungporn, Yong Poovorawan
BACKGROUND: Human papillomavirus (HPV) infection causes cervical cancer, thus necessitating early detection by screening. Rapid and accurate HPV genotyping is crucial both for the assessment of patients with HPV infection and for surveillance studies. METHODS: Fifty-eight cervicovaginal samples were tested for HPV genotypes using four methods in parallel: nested-PCR followed by conventional sequencing, INNO-LiPA, electrochemical DNA chip, and next-generation sequencing (NGS)...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29212458/associations-of-sedentary-behavior-and-physical-activity-with-older-adults-physical-function-an-isotemporal-substitution-approach
#19
Akitomo Yasunaga, Ai Shibata, Kaori Ishii, Mohammad Javad Koohsari, Shigeru Inoue, Takemi Sugiyama, Neville Owen, Koichiro Oka
BACKGROUNDS: The purpose of this study was to examine, in a sample of Japanese older adults, the associations of objectively-assessed sedentary behavior (SB) and physical activity (PA) with performance-based physical function. The isotemporal substitution (IS) approach was used to model simultaneously the effects of the specific activity being performed and the activity being displaced, in an equal time-exchange manner. METHODS: Among 287 older adults (65-84 years), we used accelerometers to identify the daily average time spent on SB (≤1...
December 6, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29204715/insight-into-the-reaction-mechanism-of-lipoyl-synthase-a-qm-mm-study
#20
Geng Dong, Lili Cao, Ulf Ryde
Lipoyl synthase (LipA) catalyses the final step of the biosynthesis of the lipoyl cofactor by insertion of two sulfur atoms at the C6 and C8 atoms of the protein-bound octanoyl substrate. In this reaction, two [4Fe4S] clusters and two molecules of S-adenosyl-L-methionine are used. One of the two FeS clusters is responsible for the generation of a powerful oxidant, the 5'-deoxyadenosyl radical (5'-dA•). The other (the auxiliary cluster) is the source of both sulfur atoms that are inserted into the substrate...
December 4, 2017: Journal of Biological Inorganic Chemistry: JBIC
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