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https://www.readbyqxmd.com/read/28197978/managing-cardiovascular-risk-in-lysosomal-acid-lipase-deficiency
#1
REVIEW
James J Maciejko
Lysosomal acid lipase deficiency (LAL-D) is a rare, life-threatening, autosomal recessive, lysosomal storage disease caused by mutations in the LIPA gene, which encodes for lysosomal acid lipase (LAL). This enzyme is necessary for the hydrolysis of cholesteryl ester and triglyceride in lysosomes. Deficient LAL activity causes accumulation of these lipids in lysosomes and a marked decrease in the cytoplasmic free cholesterol concentration, leading to dysfunctional cholesterol homeostasis. The accumulation of neutral lipid occurs predominantly in liver, spleen, and macrophages throughout the body, and the aberrant cholesterol homeostasis causes a marked dyslipidemia...
February 14, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/28174334/evidence-for-an-evolutionarily-conserved-memory-coding-scheme-in-the-mammalian-hippocampus
#2
Alexander Thome, Diano F Marrone, Timothy M Ellmore, Monica K Chawla, Peter Lipa, Victor Ramirez-Amaya, Sarah H Lisanby, Bruce L McNaughton, Carol A Barnes
: Decades of research identify the hippocampal formation as central to memory storage and recall. Events are stored via distributed population codes, whose parameters (e.g., sparsity and overlap) determine both storage capacity and fidelity. However, it remains unclear whether the parameters governing information storage are similar between species. Because episodic memories are rooted in the space in which they are experienced, the hippocampal response to navigation is often used as a proxy to study memory...
February 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28164650/emergence-of-hepatitis-c-virus-genotype-recombinant-forms-2k-1b-in-georgia
#3
Mamuka Zakalashvili, Michael Weizenegger, Jan Bartel, Monika Markowski, Jaba Zarqua, Salome Kavsadze, Ketevan Kvatadze, George Basheleishvili, Tamar Phirtskhalaishvili, Tamar Dzagania, Lela Zangurashvili, Nino Kankia, Nino Jashiashvili, Maka Lomidze, Tengiz Telia, Vakhtang Kerashvili, Maia Zhamutashvili, Nikoloz Abramishvili, Irakli Rtskhiladze, David Metreveli
BACKGROUND: Hepatitis C virus (HCV) evolution is thought to proceed by mutations within the six major genotypes. Studies of HCV recombinant genotypes in different parts of the world have recently been initiated. Only a few cases of recombination have been identified worldwide, predominantly in Eastern Europe and Asia. In 2011 we detected the recombinant form (RF) of a HCV genotype RF_2k/1b in Georgia. Therefore, we reviewed HCV genotyping data of 491 patients with chronic hepatitis C virus infections of our center in Tbilisi over a period of two years...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28121232/minimum-wear-duration-for-the-activpal%C3%A2-professional-activity-monitor-in-adolescent-females
#4
Kieran P Dowd, Helen Purtill, Deirdre M Harrington, Jane F Hislop, John J Reilly, Alan E Donnelly
OBJECTIVES: This study aims to determine the minimum number of days of monitoring required to reliably predict sitting/lying time, standing time, light intensity physical activity (LIPA), moderate-to-vigorous intensity physical activity (MVPA) and steps in adolescent females. METHODS: 195 adolescent females (mean age=15.7 years; SD=0.9) participated in the study. Participants wore the activPAL activity monitor for a seven day protocol. The amount of time spent sitting/lying, standing, in LIPA and in MVPA and the number of steps per day were quantified...
25, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28115011/recombinant-production-of-the-antibody-fragment-d1-3-scfv-with-different-bacillus-strains
#5
Antonia Lakowitz, Rainer Krull, Rebekka Biedendieck
BACKGROUND: Different strains of the genus Bacillus are versatile candidates for the industrial production and secretion of heterologous proteins. They can be cultivated quite easily, show high growth rates and are usually non-pathogenic and free of endo- and exotoxins. They have the ability to secrete proteins with high efficiency into the growth medium, which allows cost-effective downstream purification processing. Some of the most interesting and challenging heterologous proteins are recombinant antibodies and antibody fragments...
January 23, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28088318/correlation-of-the-hpv-detection-protein-expression-and-dna-content-in-cutaneous-pre-invasive-and-invasive-carcinoma-among-croatian-patients
#6
Kristina Meljanac Salopek, Stanko Jukić, Damir Babić
Development of cutaneous carcinomas has been associated with HPV infection. There have been various reports on p16, p53 and pRb expression in cutaneous carcinomas and on its linkage to HPV status. Association of protein expression and HPV infection with DNA content is not clear. The aim of this study was to determine a possible correlation between HPV type, protein expression and DNA content in both pre-invasive and invasive squamous cell carcinoma, as well as differences between studied groups in these parameters...
January 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28068366/overproduction-of-%C3%AE-lipoic-acid-by-gene-manipulated-escherichia-coli
#7
Yirong Sun, Wenbin Zhang, Jincheng Ma, Hongshen Pang, Haihong Wang
Alpha-lipoic acid (LA) is an important enzyme cofactor widely used by organisms and is also a natural antioxidant for the treatment of pathologies driven by low levels of endogenous antioxidants. In order to establish a safer and more efficient process for LA production, we developed a new biological method for LA synthesis based on the emerging knowledge of lipoic acid biosynthesis. We first cloned the lipD gene, which encodes the lipoyl domain of the E2 subunit of pyruvate dehydrogenase, allowing high levels of LipD production...
2017: PloS One
https://www.readbyqxmd.com/read/27989999/candidate-nematicidal-proteins-in-a-new-pseudomonas-veronii-isolate-identified-by-its-antagonistic-properties-against-xiphinema-index
#8
Hayron Canchignia, Fabiola Altimira, Christian Montes, Evelyn Sánchez, Eduardo Tapia, María Miccono, Daniel Espinoza, Carlos Aguirre, Michael Seeger, Humberto Prieto
The nematode Xiphinema index affects grape vines and transmits important viruses associated with fanleaf degeneration. Pseudomonas spp. are an extensive bacterial group in which important biodegradation and/or biocontrol properties can occur for several strains in the group. The aim of this study was to identify new Pseudomonas isolates with antagonist activity against X. index. Forty bacterial isolates were obtained from soil and root samples from Chilean vineyards. Thirteen new fluorescent pseudomonads were found and assessed for their antagonistic capability...
December 17, 2016: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/27984111/6-hcv-genotyping-9g-test-and-its-comparison-with-versant-hcv-genotype-2-0-assay-lipa-for-the-hepatitis-c-virus-genotyping
#9
Wasun Chantratita, Keum-Soo Song, Choi GunHo, Viroj Pongthanapisith, Nipa Thongbaiphet, Garanyuta Wongtabtim, Ekawat Pasomsub, Kanokwan Angkanavin, Satish Balasaheb Nimse, Mukesh Digambar Sonawane, Shrikant Dasharath Warkad, Taisun Kim
In this article, we describe the 6 HCV Genotyping 9G test and its evaluation by using clinical samples and plasmid DNA standards. In tests with 981 plasmid DNA standards, the 6 HCV Genotyping 9G test showed higher than 92.5% sensitivity and 99.4% specificity. The 6 HCV Genotyping 9G test was compared with the VERSANT HCV Genotype 2.0 assay (LiPA 2.0) for detection and discrimination of HCV genotypes in clinical samples. The results of both tests were verified by genomic sequencing. The 6 HCV Genotyping 9G test demonstrated a 100% agreement with the sequencing results, which was higher than LiPA 2...
October 25, 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27939875/segmental-infantile-hemangioma-with-minimal-or-arrested-growth-in-lumbar-syndrome
#10
X Calderón-Castrat, J Peceros-Escalante, F Velásquez, R M Lipa-Chancolla, R Ballona
No abstract text is available yet for this article.
December 7, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27931969/human-papillomaviruses-in-colorectal-cancers-a-case-control-study-in-western-patients
#11
Lucine Vuitton, Carine Jaillet, Elise Jacquin, Franck Monnien, Marine Heberle, Maria I Mihai, Catherine Lassabe, Johnny Raffoul, Marc Puyraveau, Zaher Lakkis, Najib Lamfichekh, Alain Picard, Jean-Luc Prétet, Christiane Mougin, Séverine Valmary-Degano
BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers. As in other cancer locations, the involvement of human papillomaviruses (HPV) has been suggested but remains highly debated with wide differences among reported prevalence of HPV infection in CRCs. AIM: To determine the actual prevalence of high risk HPV16 and 18 in a large case-control study. METHODS: CRC specimens were used for analysis of both tumor and distant healthy tissue...
November 14, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27922699/adhesion-and-invasion-of-streptococcus-pneumoniae-to-primary-and-secondary-respiratory-epithelial-cells
#12
Sara Novick, Marilous Shagan, Karin Blau, Sarit Lifshitz, Noga Givon-Lavi, Nili Grossman, Lipa Bodner, Ron Dagan, Yaffa Mizrachi Nebenzahl
The interaction between Streptococcus pneumoniae (S. pneumoniae) and the mucosal epithelial cells of its host is a prerequisite for pneumococcal disease development, yet the specificity of this interaction between different respiratory cells is not fully understood. In the present study, three areas were examined: i) The capability of the encapsulated S. pneumoniae serotype 3 strain (WU2) to adhere to and invade primary nasal‑derived epithelial cells in comparison to primary oral‑derived epithelial cells, A549 adenocarcinoma cells and BEAS‑2B viral transformed bronchial cells; ii) the capability of the unencapsulated 3...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27882767/-traumatic-symphyseal-rupture-by-vaginal-delivery-report-of-a-rare-case
#13
J Hofierková
OBJECTIVE: This case report draw attention symphysis pubic dysfunction and injury pelvic girdle by vaginal delivary (in our case compliated by dystokia shoulders), mainly its diagnostic, prediction and treatment. DESIGN: Case report. SETTING: Department of Obstetrics and Gynecology. Hospital Česká Lípa. CASE REPORT: We report a case of a 31 years old woman, who gave birth for the second time with rupture of symphysis after delivery...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27827461/association-and-interaction-of-apoa5-bud13-cetp-lipa-and-health-related-behavior-with-metabolic-syndrome-in-a-taiwanese-population
#14
Eugene Lin, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao, Shih-Jen Tsai
Increased risk of developing metabolic syndrome (MetS) has been associated with the APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 genes. In this replication study, we reassessed whether these genes are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population. We also analyzed the interactions between environmental factors and these genes in influencing MetS and its individual components. A total of 3,000 Taiwanese subjects were assessed in this study...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27819165/lipoxin-a4-lxa4-as-a-potential-first-trimester-biochemical-marker-of-intrauterine-growth-disorders
#15
Michał Lipa, Dorota Bomba-Opoń, Jacek Lipa, Paweł Bartnik, Zbigniew Bartoszewicz, Mirosław Wielgoś
OBJECTIVE: To evaluate first trimester maternal serum levels of lipoxin A4 (LXA4) in prediction of intrauterine fetal growth. METHODS: Study group of 185 patients in singleton pregnancy divided into 3 subgroups according to neonatal birthweight: ≤10 th percentile (SGA), 11- 89th percentile (AGA) and ≥90 percentile (LGA). RESULTS: We observed decreased values of LXA4 concentations, both in SGA- and LGA groups, when compared to AGA (68.91±33...
November 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27796436/enhanced-extracellular-production-of-l-asparaginase-from-bacillus-subtilis-168-by-b-subtilis-wb600-through-a-combined-strategy
#16
Yue Feng, Song Liu, Yun Jiao, Hui Gao, Miao Wang, Guocheng Du, Jian Chen
L-asparaginase (EC 3.5.1.1, ASN) exhibits great commercial value due to its uses in the food and medicine industry. In this study, we reported the enhanced expression of type II ASN from Bacillus subtilis 168 in B. subtilis WB600 through a combined strategy. First, eight signal peptides (the signal peptide of the ASN, ywbN, yvgO, amyE, oppA, vpr, lipA, and wapA) were used for ASN secretion in B. subtilis by using Hpa II promoter, respectively. The signal peptide wapA achieved the highest extracellular ASN activity (28...
October 28, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27793646/6-hcv-genotyping-9g-test-and-its-comparison-with-versant-hcv-genotype-2-0-assay-lipa-for-the-hepatitis-c-virus-genotyping
#17
Wasun Chantratita, Keum-Soo Song, Choi GunHo, Viroj Pongthanapisith, Nipa Thongbaiphet, Garanyuta Wongtabtim, Ekawat Pasomsub, Kanokwan Angkanavin, Satish Balasaheb Nimse, Mukesh Digambar Sonawane, Shrikant Dasharath Warkad, Taisun Kim
In this article, we describe the 6 HCV Genotyping 9G test and its evaluation by using clinical samples and plasmid DNA standards. In tests with 981 plasmid DNA standards, the 6 HCV Genotyping 9G test showed higher than 92.5% sensitivity and 99.4% specificity. The 6 HCV Genotyping 9G test was compared with the VERSANT HCV Genotype 2.0 assay (LiPA 2.0) for detection and discrimination of HCV genotypes in clinical samples. The results of both tests were verified by genomic sequencing. The 6 HCV Genotyping 9G test demonstrated a 100% agreement with the sequencing results, which was higher than LiPA 2...
January 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/27747194/recombination-is-a-major-driving-force-of-genetic-diversity-in-the-anaplasmataceae-ehrlichia-ruminantium
#18
Nídia Cangi, Jonathan L Gordon, Laure Bournez, Valérie Pinarello, Rosalie Aprelon, Karine Huber, Thierry Lefrançois, Luís Neves, Damien F Meyer, Nathalie Vachiéry
The disease, Heartwater, caused by the Anaplasmataceae E. ruminantium, represents a major problem for tropical livestock and wild ruminants. Up to now, no effective vaccine has been available due to a limited cross protection of vaccinal strains on field strains and a high genetic diversity of Ehrlichia ruminantium within geographical locations. To address this issue, we inferred the genetic diversity and population structure of 194 E. ruminantium isolates circulating worldwide using Multilocus Sequence Typing based on lipA, lipB, secY, sodB, and sucA genes...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27716865/breaking-up-prolonged-sitting-does-not-alter-postprandial-glycemia-in-young-normal-weight-men-and-women
#19
R K Hansen, J B Andersen, A S Vinther, U Pielmeier, R G Larsen
A randomized, controlled, cross-over study was used to investigate the effects of breaking up prolonged sitting with low intensity physical activity on postprandial blood glucose concentrations in healthy, young, normal-weight adults. 14 men (n=6) and women (n=8) were assigned to 2.5 h of prolonged sitting (CON) and 2.5 h of prolonged sitting with 2-min bouts of walking every 20 min (LIPA). After ingesting a standardized test drink, capillary blood was sampled every 10 min to establish a postprandial blood glucose profile...
December 2016: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/27706717/hpv-genotyping-and-p16-expression-in-xingu-indigenous-park-brazil
#20
V G Freitas, G R Focchi, E R Pereira, J E Levi, N M G Speck, J C Ribalta
The association between high-risk human papillomavirus (HPV) genotypes and p16 expression in indigenous women from the Xingu Indigenous Park, Brazil, was unknown. This study evaluated p16 expression in women with a histological diagnosis of cervical intraepithelial neoplasia (CIN) 3 or higher and correlated this expression with HPV genotypes to determine possible discrepancies in the expression of this marker. We evaluated 37 previously collected samples with different HPV genotypes and high-grade lesions diagnosed based on cytology, histology, and colposcopy...
September 16, 2016: Genetics and Molecular Research: GMR
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