Eveline E Vietsch, Diba Latifi, Maaike Verheij, Elise W A van der Oost, Roeland F de Wilde, Roel Haen, Anne Loes van den Boom, Bas Groot Koerkamp, Pascal G Doornebosch, Victorien M T van Verschuer, Ariadne H A G Ooms, Farzana Mohammad, Marcella Willemsen, Joachim G J V Aerts, Ricki T Krog, Noel F C C de Miranda, Thierry P P van den Bosch, Yvonne M Mueller, Peter D Katsikis, Casper H J van Eijck
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest solid tumors and is resistant to immunotherapy. B cells play an essential role in PDAC progression and immune responses, both locally and systemically. Moreover, increasing evidence suggests that microbial compositions inside the tumor, as well as in the oral cavity and the gut, are important factors in shaping the PDAC immune landscape. However, the gut-associated lymphoid tissue (GALT) has not previously been explored in PDAC patients. In this study, we analyzed healthy vermiform appendix (VA) from 20 patients with PDAC and 32 patients with colon diseases by gene expression immune profiling, flow cytometry analysis, and microbiome sequencing...
2023: Frontiers in Immunology