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https://www.readbyqxmd.com/read/29662139/decreased-expression-of-jhdmid-in-placenta-is-associated-with-preeclampsia-through-hla-g
#1
Shouling Luo, Jiangnan Pei, Xiaotian Li, Weirong Gu
The exact mechanism of preeclampsia (PE) remains unclear, accumulating researches have indicated multiple epigenetic factors relate to PE and histone methylation plays a crucial role in modifying the gene expression. So we aimed to confirm that abnormal expression of histone demethylase JHDM1D contributes to PE and lower expression of HLA-G in PE. We tested the expression of JHDM1D, H3K9me2, and H3K27me2 in the placentas of PE and normal control (NC)women who had a healthy pregnancy with Immunohistochemistry and we found that JHDM1D, H3K9me2, and H3K27me2 were all mainly expressed in the nuclei of the extra-villous trophoblasts (EVTs)...
April 6, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29660112/evaluation-of-membrane-bound-and-soluble-forms-of-hla-g-in-systemic-sclerosis
#2
Paola Contini, Simone Negrini, Giuseppe Murdaca, Matteo Borro, Francesco Puppo
Systemic sclerosis (SSc) is a complex disease characterized by immune dysregulation, extensive vascular damage and wide-spread fibrosis. Human leukocyte antigen-G (HLA-G) is a non-classic class I major histocompatibility complex (MHC) molecule characterized by complex immuno-modulating properties. HLA-G is expressed on the membrane of different cell lineages in both physiological and pathological conditions. HLA-G is also detectable in soluble form (sHLA-G) deriving from the shedding of surface isoforms (sHLA-G1) or the secretion of soluble isoforms (HLA-G5)...
April 16, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29618829/the-genetic-diversity-within-the-1-4-kb-hla-g-5-upstream-regulatory-region-moderately-impacts-on-cellular-microenvironment-responses
#3
Fabrício C Dias, Bruna C Bertol, Isabelle Poras, Bruno M Souto, Celso T Mendes-Junior, Erick C Castelli, Laure Gineau, Audrey Sabbagh, Nathalie Rouas-Freiss, Edgardo D Carosella, Eduardo A Donadi, Philippe Moreau
The HLA-G 5'URR extending 1.4 kb from the ATG presents a unique set of regulatory elements among HLA genes. Several variable sites have been described that coincide with or are close to these elements, thus HLA-G 5'URR polymorphism might influence the HLA-G expression level. We cloned the ten most frequent HLA-G 5'URR haplotypes to evaluate their activity on a luciferase reporter gene in HLA-G+ cell lines (JEG-3/choriocarcinoma and FON+ /melanoma). We also investigated associations between the plasma HLA-G (sHLA-G) levels and the HLA-G 5'URR variability in 157 healthy individuals...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29608700/trophoblast-retrieval-and-isolation-from-the-cervix-origins-of-cervical-trophoblasts-and-their-potential-value-for-risk-assessment-of-ongoing-pregnancies
#4
Gerit Moser, Sascha Drewlo, Berthold Huppertz, D Randall Armant
BACKGROUND: Early during human development, the trophoblast lineage differentiates to commence placentation. Where the placenta contacts the uterine decidua, extravillous trophoblast (EVT) cells differentiate and invade maternal tissues. EVT cells, identified by expression of HLA-G, invade into uterine blood vessels (endovascular EVT), as well as glands (endoglandular EVT), and open such luminal structures towards the intervillous space of the placenta. Endoglandular invasion diverts the contents of uterine glands to the intervillous space, while glands near the margin of the placenta that also contain endoglandular EVT cells open into the reproductive tract...
March 28, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29605689/hla-g-mediated-immune-regulation-is-impaired-by-a-single-amino-acid-exchange-in-the-alpha-2-domain
#5
Alexander A Celik, Gwendolin S Simper, Trevor Huyton, Rainer Blasczyk, Christina Bade-Döding
The trade-off from HLA class I expression to HLA-G expression support the immune evasion of malignant cells. The essential role of the virtually invariant HLA-G in immune tolerance, tumor immunology and its expression frequency in immune privileged tissues is known; however the specific importance of allelic subtypes in immune responses is still not well understood. HLA-G∗01:01, ∗01:03 and ∗01:04 are the most prevalent allelic variants differing at residues 31 and 110, respectively. In cytotoxicity assays applying K562 cells transduced with the HLA-G variants as targets and NK cells as effectors the differential protective potential of HLA-G variants was analyzed...
March 29, 2018: Human Immunology
https://www.readbyqxmd.com/read/29603194/immune-privilege-disruption-in-folliculotropic-mycosis-fungoides-investigation-of-major-histocompatibility-complex-antigen-expression
#6
Janyana M D Deonizio, Joan Guitart, Pedram Yazdan, Fabiane Mulinari-Brenner, Mirian N Sotto, José A Sanches
BACKGROUND: Folliculotropic mycosis fungoides (FMF) is a cutaneous T-cell lymphoma mainly affecting the hair follicle, which seems to represent a place of immune privilege phenomenon. OBJECTIVES: To explore a possible role of immune privilege (IP) in FMF analyzing the major histocompatibility complex (MHC) expression. METHODS: Immunohistochemistry for HLA-G and MHC-II was performed to formalin-fixed paraffin-embedded cutaneous skin biopsies of FMF patients (n = 43), conventional mycosis fungoides (CMF; n = 13), alopecia areata (AA; n = 13), and normal scalp skin (NS; n = 12)...
March 30, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29602958/hla-g-peptide-preferences-change-in-transformed-cells-impact-on-the-binding-motif
#7
Alexander A Celik, Gwendolin S Simper, Wiebke Hiemisch, Rainer Blasczyk, Christina Bade-Döding
HLA-G is known for its strictly restricted tissue distribution. HLA-G expression could be detected in immune privileged organs and many tumor entities such as leukemia, multiple myeloma, and non-Hodgkin and Hodgkin's lymphoma. This functional variability from mediation of immune tolerance to facilitation of tumor immune evasion strategies might translate to a differential NK cell inhibition between immune-privileged organs and tumor cells. The biophysical invariability of the HLA-G heavy chain and its contrary diversity in immunity implicates a strong influence of the bound peptides on the pHLA-G structure...
March 30, 2018: Immunogenetics
https://www.readbyqxmd.com/read/29588183/hla-g-is-expressed-in-intestinal-samples-of-ulcerative-colitis-and-crohn-s-disease-patients-and-hla-g5-expression-is-differentially-correlated-with-tnf-and-il-10-cytokine-expression
#8
Renan Garcia Gomes, Carlos Alexandre Antunes de Brito, Valéria Ferreira Martinelli, Rossana Nascimento Dos Santos, Fabiana Oliveira Dos Santos Gomes, Christina Alves Peixoto, Janaína Oliveira Crispim, George Tadeu Nunes Diniz, Eduardo Antônio Donadi, Norma Lucena-Silva
HLA-G is an immunomodulatory molecule that can be produced by epithelial cells. Considering that TNF and IL-10 participate in bowel inflammatory disorders and that both cytokines modulate HLA-G, we evaluated HLA-G, TNF and IL-10 mRNA expression by qPCR and HLA-G protein levels by immunohistochemistry in two intestinal samples exhibiting different degree of inflammation within a patient suffering from Crohn's disease (CD) or ulcerative colitis (UC). Tissue HLA-G5 (P<0.0001), TNF (P=0.0004) and IL-10 (P=0...
March 24, 2018: Human Immunology
https://www.readbyqxmd.com/read/29587858/hla-and-proteasome-expression-body-map
#9
Sebastian Boegel, Martin Löwer, Thomas Bukur, Patrick Sorn, John C Castle, Ugur Sahin
BACKGROUND: The presentation of HLA peptide complexes to T cells is a highly regulated and tissue specific process involving multiple transcriptionally controlled cellular components. The extensive polymorphism of HLA genes and the complex composition of the proteasome make it difficult to map their expression profiles across tissues. METHODS: Here we applied a tailored gene quantification pipeline to 4323 publicly available RNA-Seq datasets representing 55 normal tissues and cell types to examine expression profiles of (classical and non-classical) HLA class I, class II and proteasomal genes...
March 27, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29559123/inhibiting-hla-g-restores-ifn-%C3%AE-and-tnf-%C3%AE-producing-t-cell-in-pleural-tuberculosis
#10
Abhinav Saurabh, Sushmita Chakraborty, Prabin Kumar, Anant Mohan, Anuj K Bhatnagar, Narayan Rishi, Dipendra Kumar Mitra
Human Leukocyte Antigen-G (HLA-G), a non-classical, class Ib molecule, has been shown to mediate immunoregulatory functions by inducing apoptosis, inhibits cytotoxicity and differentiation by modulating cytokine secretion. Due to its immune-suppressive function, it facilitates tolerance in feto-maternal interface and transplantation. In contrary, it favours immune evasion of microbes and tumors by inhibiting immune and inflammatory responses. In Tuberculosis (TB), we previously reported differential expression of HLA-G and its receptor Ig-like transcript -2 (ILT-2) in disseminated vs...
March 2018: Tuberculosis
https://www.readbyqxmd.com/read/29549230/prognostic-value-of-hla-g-in-malignant-liver-and-pancreas-lesions
#11
Parisa Khodabandeh Shahraki, Yasmin Zare, Negar Azarpira, Massood Hosseinzadeh, Shirin Farjadian
BACKGROUND: Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule with modulatory effects on NK and T cells. Because HLA-G expression is frequently detected in different solid tumors, it may be involved in tumor immune evasion. OBJECTIVE: This study was designed to elucidate the prognostic value of HLA-G in hepatocellular carcinoma (HCC) and pancreatic adenocarcinoma (PADC). The influence of hepatitis B virus (HBV) infection on HLA-G expression was also evaluated in patients with HCC...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29545200/alterations-in-placental-gene-expression-of-pregnant-women-with-chronic-chagas-disease
#12
Natalia Anahí Juiz, Irma Torrejón, Marianela Burgos, Ana María Fernanda Torres, Tomás Duffy, Nelly Melina Cayo, Anahí Tabasco, Miriam Salvo, Silvia Andrea Longhi, Alejandro Gabriel Schijman
Infection with Trypanosoma cruzi in women at reproductive age is associated with congenital transmission and adverse pregnancy outcome. The placenta is a key barrier to infection. We characterized gene expression profiles of term placental environment from T. cruzi seropositive (SP) and seronegative (SN) mothers performing RNA-seq. Nine pools of placental RNA paired samples were used: three from SN and six from SP tissues. Each pool consisted of female/male newborns and vaginal/caesarean deliveries binomials...
March 12, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29544814/hla-g-and-vertical-mother-to-child-transmission-of-human-papillomavirus-infection
#13
Karolina Louvanto, Michel Roger, Marie-Claude Faucher, Kari Syrjänen, Seija Grenman, Stina Syrjänen
Role of host factors in transmission of human papillomavirus (HPV)-infection from mother to her offspring is not known. Our aim was to study whether human leukocyte antigen (HLA)-G allele concordance among the mother-child pairs could facilitate vertical transmission of HPV, because HLA-G may contribute to immune tolerance in pregnancy. Altogether, 310 mother-child pairs were included from the Finnish Family HPV study. Overall, nine different HLA-G alleles were identified. The HLA-G genotype concordance of G∗01:01:01/01:04:01 increased the risk of high risk (HR)-HPV genotype positivity in cord blood and infant's oral mucosa...
March 12, 2018: Human Immunology
https://www.readbyqxmd.com/read/29540850/elevated-soluble-human-leukocyte-antigen-g-levels-in-patients-after-allogeneic-stem-cell-transplantation-are-associated-with-less-severe-acute-and-chronic-graft-versus-host-disease
#14
Lambros Kordelas, Fabiola da Silva Nardi, Bettina Wagner, Markus Ditschkowski, Tobias Liebregts, Monika Lindemann, Falko M Heinemann, Peter A Horn, Dietrich W Beelen, Vera Rebmann
HLA-G is a non-classical class I molecule which induces tolerance in allogeneic situations by inhibition of cytotoxic NK and CD8 + T cells and by induction of regulatory T cells. Concordantly, in solid organ transplantation HLA-G is associated with a lower risk for acute and chronic rejection, whereas its role in allogeneic stem cell transplantation (allo-SCT) is less established. We here present detailed analyses of HLA-G-levels in patients after allo-SCT showing a correlation of elevated soluble HLA-G (sHLA-G) levels with less severe acute (p = 0...
March 14, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29540242/comparison-of-single-nucleotide-polymorphisms-in-the-3-untranslated-region-of-hla-g-in-placentas-between-spontaneous-preterm-birth-and-preeclampsia
#15
Ji Young Lee, Hyun Mi Kim, Mi Ju Kim, Hyun-Hwa Cha, Won Joon Seong
OBJECTIVE: To compare single nucleotide polymorphisms (SNPs) in the 3'-untranslated region (3'UTR) of human leukocyte antigen (HLA)-G in placentas between spontaneous preterm birth and preeclampsia pregnancies. RESULTS: Placental samples matched for gestational age were obtained from 20 cases of spontaneous preterm births and 19 cases of preeclampsia. Genomic deoxyribonucleic acid was extracted from placenta tissue and the 3'UTR region of HLA-G was amplified via polymerase chain reaction...
March 14, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29528338/lilrb1-polymorphisms-influence-posttransplant-hcmv-susceptibility-and-ligand-interactions
#16
Kang Yu, Chelsea L Davidson, Agnieszka Wójtowicz, Luiz Lisboa, Ting Wang, Adriana M Airo, Jean Villard, Jeremie Buratto, Tatyana Sandalova, Adnane Achour, Atul Humar, Katia Boggian, Alexia Cusini, Christian van Delden, Adrian Egli, Oriol Manuel, Nicolas Mueller, Pierre-Yves Bochud, Deborah N Burshtyn
UL18 is a human CMV (HCMV) MHC class I (MHCI) homolog that efficiently inhibits leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1)+ NK cells. We found an association of LILRB1 polymorphisms in the regulatory regions and ligand-binding domains with control of HCMV in transplant patients. Naturally occurring LILRB1 variants expressed in model NK cells showed functional differences with UL18 and classical MHCI, but not with HLA-G. The altered functional recognition was recapitulated in binding assays with the binding domains of LILRB1...
March 12, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29527207/-hla-g-haplotypes-are-differentially-associated-with-asthmatic-features
#17
Camille Ribeyre, Federico Carlini, Céline René, François Jordier, Christophe Picard, Jacques Chiaroni, Laurent Abi-Rached, Philippe Gouret, Grégory Marin, Nicolas Molinari, Pascal Chanez, Julien Paganini, Delphine Gras, Julie Di Cristofaro
Human leukocyte antigen (HLA)-G, a HLA class Ib molecule, interacts with receptors on lymphocytes such as T cells, B cells, and natural killer cells to influence immune responses. Unlike classical HLA molecules, HLA-G expression is not found on all somatic cells, but restricted to tissue sites, including human bronchial epithelium cells (HBEC). Individual variation in HLA-G expression is linked to its genetic polymorphism and has been associated with many pathological situations such as asthma, which is characterized by epithelium abnormalities and inflammatory cell activation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29507047/immune-landscape-of-papillary-thyroid-cancer-and-immunotherapeutic-implications
#18
Kwon Joong Na, Hongyoon Choi
Although papillary thyroid cancer (PTC) is curable with excellent survival rate, patients with dedifferentiated PTC suffer the recurrence or death. As cancer immune escape plays a critical role in cancer progression, we aimed to investigate the relationship between differentiation and immune landscape of PTC and its implications for immunotherapy. Using the Cancer Genome Atlas data, we estimated the immune cell enrichment scores and overall immune infiltration, ImmuneScore, to characterize the immune landscape of PTC...
March 5, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29499226/clinicopathologic-significance-of-hla-g-and-hla-e-molecules-in-tunisian-patients-with-ovarian-carcinoma
#19
Wafa Babay, Hamza Ben Yahia, Nadia Boujelbene, Nour Zidi, Ahmed Baligh Laaribi, Dhikra Kacem, Radhia Ben Ghorbel, Abdellatif Boudabous, Hadda-Imene Ouzari, Roberta Rizzo, Vera Rebmann, Karima Mrad, Inès Zidi
BACKGROUND: The human leukocyte antigen (HLA)-G and HLA-E, non classical HLA class I molecules, have been highly implicated in immune tolerance. HLA-G and HLA-E molecules were proposed as putative markers of several advanced cancers. As a step towards a better understanding of ovarian carcinoma, we evaluated the expression of both HLA-G and HLA-E molecules and explored their prognostic implication. METHODS: HLA-G and HLA-E expression were studied by immunohistochemistry on ovarian carcinoma tissues...
February 27, 2018: Human Immunology
https://www.readbyqxmd.com/read/29491867/acquired-natural-killer-cell-dysfunction-in-the-tumor-microenvironment-of-classic-hodgkin-lymphoma
#20
REVIEW
Jodi Chiu, Daniel M Ernst, Armand Keating
An understanding of interactions within the tumor microenvironment (TME) of classic Hodgkin lymphoma (cHL) has helped pave the way to novel immunotherapies that have enabled dormant and tumor-tolerant immune cells to be reactivated. The immunosuppressive nature of the TME in cHL specifically inhibits the proliferation and activity of natural killer (NK) cells, which contributes to tumor immune-escape mechanisms. This deficiency of NK cells begins at the tumor site and progresses systemically in patients with advanced disease or adverse prognostic factors...
2018: Frontiers in Immunology
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