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https://www.readbyqxmd.com/read/28721719/imprinted-nanovelcro-microchips-for-isolation-and-characterization-of-circulating-fetal-trophoblasts-toward-noninvasive-prenatal-diagnostics
#1
Shuang Hou, Jie-Fu Chen, Min Song, Yazhen Zhu, Yu Jen Jan, Szu Hao Chen, Tzu-Hua Weng, Dean-An Ling, Shang-Fu Chen, Tracy Ro, An-Jou Liang, Tom Lee, Helen Jin, Man Li, Lian Liu, Yu-Sheng Hsiao, Peilin Chen, Hsiao-Hua Yu, Ming-Song Tsai, Margareta D Pisarska, Angela Chen, Li-Ching Chen, Hsian-Rong Tseng
Circulating fetal nucleated cells (CFNCs) in maternal blood offer an ideal source of fetal genomic DNA for noninvasive prenatal diagnostics (NIPD). We developed a class of nanoVelcro microchips to effectively enrich a subcategory of CFNCs, i.e., circulating trophoblasts (cTBs) from maternal blood, which can then be isolated with single-cell resolution by a laser capture microdissection (LCM) technique for downstream genetic testing. We first established a nanoimprinting fabrication process to prepare the LCM-compatible nanoVelcro substrates...
July 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28712403/-serum-soluble-hla-g-soluble-cd30-is-correlated-to-the-time-after-transplantation-in-renal-transplant-recipients
#2
Zhankui Jin, Cuixiang Xu, Wanli Duan, Jiangcun Yang, Puxun Tian
Objective To investigate the expressions of serum soluble human leukocyte antigen G (sHLA-G) and soluble CD30 (sCD30) in renal transplant recipients at different time after transplantation, and explore the relationship between the expressions of serum sHLA-G, sCD30 and the time after renal transplantation. Methods Eleven kidney transplant recipients and 10 healthy donors were selected, in which the dynamic changes of serum sHLA-G and sCD30 were detected by ELISA before transplantation and 1 year after transplantation; 33 kidney transplant recipients with normal renal graft were selected and divided into three groups: 1-5 years, 5-10 years and 10 years post-transplantation...
July 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28711734/immunohistochemical-investigations-on-the-expression-of-programmed-cell-death-ligand-1-human-leukocyte-antigens-g-and-e-and-granzyme-b-in-intraoral-mucoepidermoid-carcinoma
#3
Carla Mosconi, Diego Antônio Costa Arantes, Andréia Souza Gonçalves, Rita de Cássia Gonçalves Alencar, José Carlos Oliveira, Tarcília Aparecida Silva, Elismauro Francisco Mendonça, Aline Carvalho Batista
OBJECTIVE: To identify the expression of nonclassical human leukocyte antigen G and E (HLA-G and -E), programmed cell death ligand-1 (PD-L1) and granzyme B (GB) in intraoral mucoepidermoid carcinomas (MECs), and to assess whether such expressions are related to metastasis, survival, staging, tumor grade and number of GB-positive cells. DESIGN: For this cross-sectional study, samples of MEC (n=30) were selected and classified as low-grade (LG), intermediate-grade (IG) or high-grade (HG), according to the WHO grading system...
July 8, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28707147/the-hla-g-14-bp-polymorphism-and-recurrent-implantation-failure-a-meta-analysis
#4
REVIEW
Wei Fan, Zhongying Huang, Shangwei Li, Zhun Xiao
PURPOSE: The human leucocyte antigen-G (HLA-G) 14-bp insertion/deletion polymorphism was implicated in recurrent implantation failure (RIF), but individual published studies showed inconclusive results. Thus, a meta-analysis was performed to clarify the effect of HLA-G 14-bp polymorphism on RIF risk. METHODS: A comprehensive search for relevant articles was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for HLA-G 14-bp polymorphism and RIF were calculated...
July 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28702027/decreased-human-leukocyte-antigen-g-expression-by-mir-133a-contributes-to-impairment-of-proinvasion-and-proangiogenesis-functions-of-decidual-nk-cells
#5
Wenwei Guo, Liang Fang, Bo Li, Xifeng Xiao, Shuqiang Chen, Jun Wang, Fang Yang, Lihua Chen, Xiaohong Wang
Human leukocyte antigen (HLA)-G plays a crucial role in conferring fetal-maternal tolerance and ensuring a successful pregnancy. CD56(bright) natural killer (NK) cells accumulate at the maternal decidua in large numbers during pregnancy and are found in direct contact with fetal trophoblasts. There are increasing evidences that decidual NK (dNK) cells are crucial for pregnancy. However, the regulation of dNK cells is mostly unknown. Here, we provide evidences that the secretion function of dNK cells in recurrent spontaneous abortion was impaired, which led to the impairment of the proinvasion and proangiogenesis functions of dNK cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28701751/secretome-of-in-vitro-cultured-human-embryos-contains-extracellular-vesicles-that-are-uptaken-by-the-maternal-side
#6
Elisa Giacomini, Riccardo Vago, Ana Maria Sanchez, Paola Podini, Natasa Zarovni, Valentina Murdica, Roberta Rizzo, Daria Bortolotti, Massimo Candiani, Paola Viganò
Communication between embryo and maternal endometrium occurs during a specific time frame in which implantation is possible. Here we demonstrate for the first time that conditioned media from non-manipulated human embryos cultured in vitro for 3 days or up to the blastocyst stage contain extracellular vesicles (EVs) with a diameter of 50 to 200 nm and bearing the traditional microvesicle and exosome marker proteins CD63, CD9 and ALIX. The embryonic origin of these EVs has been confirmed by the presence of stemness gene transcripts and their enrichment in the non-classical HLA-G protein...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699111/hla-class-ib-in-pregnancy-and-pregnancy-related-disorders
#7
REVIEW
Gry Persson, Wenna Nascimento Melsted, Line Lynge Nilsson, Thomas Vauvert F Hviid
The HLA class Ib genes, HLA-E, HLA-F, and HLA-G, were discovered long after the classical HLA class Ia genes. The elucidation of their functions had a modest beginning. However, their basic functions and involvement in pathophysiology and a range of diseases are now emerging. Although results from a range of studies support the functional roles for the HLA class Ib molecules in adult life, especially HLA-G and HLA-F have most intensively been, and were also primarily, studied in relation to reproduction and pregnancy...
July 11, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28695673/gene-polymorphism-and-hla-g-expression-in-patients-with-childhood-onset-systemic-lupus-erythematosus-a-pilot-study
#8
A Cavalcanti, R Almeida, Z Mesquita, A L B P Duarte, E A Donadi, N Lucena-Silva
Human leukocyte antigen-G (HLA-G) presents inhibitory functions in immune cells and is located in a chromosomal region associated with systemic lupus erythematosus (SLE) susceptibility. Polymorphisms in 3' untranslated region (3'UTR) of HLA-G gene may influence protein expression. To date, no study analyzing HLA-G polymorphism and expression in childhood-onset systemic lupus erythematosus (cSLE) has been conducted. Therefore, we investigated the influence of HLA-G 3'UTR polymorphisms in 50 cSLE patients and 144 healthy controls...
July 11, 2017: HLA
https://www.readbyqxmd.com/read/28691395/low-expression-of-soluble-human-leukocyte-antigen-g-in-early-gestation-and-subsequent-placenta-mediated-complications-of-pregnancy
#9
Luca Marozio, Anna Garofalo, Paola Berchialla, Anna Maria Tavella, Loredana Salton, Franco Cavallo, Chiara Benedetto
AIM: Abnormal placentation is a common pathogenic mechanism of many placenta-mediated complications of late pregnancy, including pre-eclampsia, fetal growth restriction, stillbirth, and placental abruption. During successful placentation, the trophoblast (which is a semi-allograft) is not rejected by decidual immune cells because of maternal immune tolerance, mainly induced by human leukocyte antigen G (HLA-G). Deficient HLA-G expression seems to be associated with the development of complications of pregnancy...
July 10, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28675838/therapeutic-application-of-human-leukocyte-antigen-g1-improves-atopic-dermatitis-like-skin-lesions-in-mice
#10
Naoyoshi Maeda, Chisato Yamada, Ami Takahashi, Kimiko Kuroki, Katsumi Maenaka
Human leukocyte antigen (HLA)-G is an immune checkpoint molecule that plays critical roles in immune response and in triggering inhibitory signaling to immune cells such as T cells, natural killer cells, and antigen-presenting cells. Thus, the application of HLA-G can be considered for treating immune response-related inflammatory disorders. We have previously reported that treatment with HLA-G1 and HLA-G2 ameliorates the joint swelling associated with collagen-induced arthritis of DBA/1 mice, an animal model for rheumatoid arthritis...
July 1, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28655969/the-immunosignature-of-mother-fetus-couples-in-gestational-diabetes-mellitus-role-of-hla-g-14%C3%A2-bp-ins-del-and-papp-a-a-c-polymorphisms-in-the-uterine-inflammatory-milieu
#11
Miryam Martinetti, Fausta Beneventi, Cristina Capittini, Elena Locatelli, Margherita Simonetta, Chiara Cavagnoli, Irene De Maggio, Annalisa De Silvestri, Annamaria Pasi, Arsenio Spinillo
We enrolled 151 healthy mother/newborn couples and 26 with gestational diabetes mellitus (GDM). HLA-G and PAPP-A plasma levels were measured by ELISA at first and second trimesters, at delivery, and in cord blood. HLA-G 14 bp ins/del and PAPP-A A/C polymorphisms were genotyped. HLA-G del/del and PAPP-A C/C genotypes were more frequent among GDM mothers than controls. We observed a genetic epistasis between the two polymorphisms: the HLA-G del/del and PAPP-A C/C combination was carried by 8% of GDM mothers and 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/28653974/hla-g-3-utr-polymorphisms-predict-drug-induced-g3-4-toxicity-related-to-folinic-acid-5-fluorouracil-oxaliplatin-folfox4-chemotherapy-in-non-metastatic-colorectal-cancer
#12
Marica Garziera, Saverio Virdone, Elena De Mattia, Lucia Scarabel, Erika Cecchin, Jerry Polesel, Mario D'Andrea, Nicoletta Pella, Angela Buonadonna, Adolfo Favaretto, Giuseppe Toffoli
Polymorphisms in drug-metabolizing enzymes might not completely explain inter-individual differences in toxicity profiles of patients with colorectal cancer (CRC) that receive folinic acid/5-fluorouracil/oxaliplatin (FOLFOX4). Recent data indicate that the immune system could contribute to FOLFOX4 outcomes. In light of the immune inhibitory nature of human leukocyte antigen-G (HLA-G), a non-classical major histocompatibility complex (MHC) class I molecule, we aimed to identify novel genomic markers of grades 3 and 4 (G3-4) toxicity related to FOLFOX4 therapy in patients with CRC...
June 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28627421/hla-g%C3%A2-14bp-insertion-and-the-kir2ds1-hlac2-complex-impact-on-behavioral-impairment-in-children-with-autism-spectrum-disorders
#13
Franca R Guerini, Elisabetta Bolognesi, Matteo Chiappedi, Alessandro Ghezzo, Salvatorica Manca, Michela Zanette, Stefano Sotgiu, Maria Martina Mensi, Milena Zanzottera, Cristina Agliardi, Andrea S Costa, Umberto Balottin, Mario Clerici
Activating KIR-HLA-C ligand complexes and HLA-G∗14bp insertion/deletion (+/-) polymorphism were associated to Autism Spectrum Disorders (ASD) and were suggested to correlate with inflammation during fetal development. We evaluated whether HLA-G∗14bp(+/-) and KIRs-HLA-C complexes are associated with cognitive and behavioral scores and EEG profile in 119 ASD children (58 from Sardinia, 61 from Peninsular Italy). KIR2DS1-C2; KIR2DS2-C1; KIR2DL1-C2; KIR2DL2-C1; KIR2DL3-C1 and HLA-G∗14bp(+/-) were molecularly genotyped by SSP and gel electrophoresis...
June 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28623976/adam28-localizes-to-hla-g-trophoblasts-and-promotes-column-cell-outgrowth
#14
L C De Luca, H T Le, D L Mara, A G Beristain
INTRODUCTION: Trophoblast progenitor cell differentiation towards the extravillous trophoblast (EVT) lineage initiates within proximal regions of anchoring columns of first trimester placental villi. While molecular processes controlling the initial stages of progenitor cell differentiation along the EVT pathway have been described, much remains unknown about factors important in distal column cell differentiation into invasive EVTs. ADAMs are proteases that regulate growth factor signaling, cell-matrix adhesion, and matrix proteolysis, and thus impact many processes relevant in placentation...
July 2017: Placenta
https://www.readbyqxmd.com/read/28603738/immunosuppressive-role-of-extracellular-vesicles-hla-g-an-important-player
#15
EDITORIAL
Cristina Grange, Giovanni Camussi
No abstract text is available yet for this article.
May 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28600033/evaluation-of-hla-g-14-bp-ins-del-and%C3%A2-3142g-c-polymorphisms-with-susceptibility-to-recurrent-spontaneous-abortion
#16
Mohammad Hashemi, Mojgan Mokhtari, Safura Khazaeian, Gholamreza Bahari, Maryam Rezaei, Alireza Nakhaee, Mohsen Taheri
OBJECTIVE: HLA-G is critically important for successful implantation during pregnancy. Increasing evidence supposed that HLA-G plays a key role in tolerance of the semi-allogeneic graft in pregnancy by inhibiting the cytotoxic functions of T and NK cells. The present study aimed to evaluate the impact of HLA-G rs1063320 (+3142G>C) and 14-bp insertion (ins)/deletion (del) polymorphisms on recurrent spontaneous abortion (RSA). MATERIALS AND METHODS: Genomic DNA from 93 RSA patients and 93 normal fertile women was isolated using the salting out method...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28593875/intrauterine-growth-restriction-and-placental-gene-expression-in-severe-preeclampsia-comparing-early-onset-and-late-onset-forms
#17
Jaana Nevalainen, Sini Skarp, Eeva-Riitta Savolainen, Markku Ryynänen, Jouko Järvenpää
OBJECTIVE: To evaluate placental gene expression in severe early- or late-onset preeclampsia with intrauterine growth restriction compared to controls. STUDY DESIGN: Chorionic villus sampling was conducted after cesarean section from the placentas of five women with early- or late-onset severe preeclampsia and five controls for each preeclampsia group. Microarray analysis was performed to identify gene expression differences between the groups. RESULTS: Pathway analysis showed over-representation of gene ontology (GO) biological process terms related to inflammatory and immune response pathways, platelet development, vascular development, female pregnancy and reproduction in early-onset preeclampsia...
April 13, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28591688/qa-2-expression-levels-is-related-with-tumor-infiltrating-lymphocytes-profile-during-solid-ehrlich-tumor-development
#18
Istéfani Luciene da Silva, Emerson Soares Veloso, Ivy Nayra Nascimento Gonçalves, Ariadne Duarte Braga, Miriam Teresa Paz Lopes, Geovanni Dantas Cassali, Miguel Quintanilla, Renata Toscano Simões, Enio Ferreira
The Qa-2 has been described as Human Leucocyte Antigen G (HLA-G) murine homolog. This homology is well accepted to gene and protein structure, in different pathology process and embryos implantation. However, in some neoplasm, this homology is questioned, where Qa-2 has been proposed as an immunogenic molecule, associated to tumor rejection. In this way, the aim of this study was to describe the pattern of Qa-2 expression and its relationship with the profile of tumor-infiltrating lymphocytes in solid Ehrlich tumor...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28557312/a-novel-hla-g-allele-hla-g-01-01-01-07-was-identified-in-a-chinese-patient-with-posner-schlossman-syndrome
#19
J Zhao, X-S Huang, S-M Peng, S-Y Mei, Y-P Xu
A novel HLA-G allele, HLA-G*01:01:01:07, was identified in a Chinese patient with Posner-Schlossman syndrome.
May 30, 2017: HLA
https://www.readbyqxmd.com/read/28523429/kir-lilrb-and-their-ligands-genes-as-potential-biomarkers-in-recurrent-implantation-failure
#20
REVIEW
Izabela Nowak, Karolina Wilczyńska, Jacek R Wilczyński, Andrzej Malinowski, Paweł Radwan, Michał Radwan, Piotr Kuśnierczyk
Reproductive failure in humans is a very important social and economic problem, because nowadays women decide to conceive later in life and delay motherhood. Unfortunately, with increasing age they have less chance for natural fertilization and maintenance of pregnancy. Many of them need assisted reproductive technology. Approximately 10% of women after in vitro fertilization-embryo transfers experience recurrent implantation failure (RIF). Multiple factors may contribute to RIF, including oocyte and sperm quality, parental chromosomal anomalies, genetic or metabolic abnormalities of the embryo, poor uterine receptivity, immunological disturbances in the implantation site, and some gynecologic pathologies such as endometriosis, uterine fibroids, hydrosalpinx and endometrial polyps...
May 18, 2017: Archivum Immunologiae et Therapiae Experimentalis
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