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https://www.readbyqxmd.com/read/29245066/immuno-biological-comparison-of-hepatic-stellate-cells-in-a-reverted-and-activated-state
#1
Mehdi Najar, Hussein Fayyad-Kazan, Wissam H Faour, Adil El Taghdouini, Gordana Raicevic, Leo A van Grunsven, Mustapha Najimi, Etienne Sokal, Laurence Lagneaux
Human hepatic stellate cells (HSCs) demonstrated great immunological plasticity with important consequences for liver cell therapy. Activated HSCs (aHSCs) are in vitro reverted (rHSCs) to a quiescent-like phenotype with potential benefit to reduce liver fibrosis. The goal of this study is to establish and compare the immunological profile of activated and in vitro reverted HSCs and to investigate the impact of inflammatory priming on the immunobiology of both HSCs populations. The distribution of inflammatory primed activated and reverted HSCs across the different phases of the cell cycle is assessed by flow cytometry...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29234882/the-impact-of-hla-g-lilrb1-and-lilrb2-gene-polymorphisms-on-susceptibility-to-and-severity-of-endometriosis
#2
Aleksandra Bylińska, Karolina Wilczyńska, Jacek Malejczyk, Łukasz Milewski, Marta Wagner, Monika Jasek, Wanda Niepiekło-Miniewska, Andrzej Wiśniewski, Rafał Płoski, Ewa Barcz, Piotr Roszkowski, Paweł Kamiński, Andrzej Malinowski, Jacek R Wilczyński, Paweł Radwan, Michał Radwan, Piotr Kuśnierczyk, Izabela Nowak
Endometriosis is a disease in which endometriotic tissue occurs outside the uterus. Its pathogenesis is still unknown. The most widespread hypothesis claims that ectopic endometrium appears as a result of retrograde menstruation and its insufficient elimination by immunocytes. Some reports have shown expression of non-classical HLA-G molecules on ectopic endometrium. HLA-G is recognized by KIR2DL4, LILRB1 and LILRB2 receptors on natural killer (NK) and other cells. These receptors are polymorphic, which may affect their activity...
December 12, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29224003/human-leukocyte-antigen-g-inhibits-the-anti-tumor-effect-of-natural-killer-cells-via-immunoglobulin-like-transcript-2-in-gastric-cancer
#3
Rui Wan, Zi-Wei Wang, Hui Li, Xu-Dong Peng, Guang-Yi Liu, Jun-Ming Ou, An-Qi Cheng
BACKGROUND/AIMS: Human leukocyte antigen-G (HLA-G) plays an important role in inhibiting natural killer (NK) cell function and promoting immune escape. However, the specific mechanism of HLA-G on NK in gastric cancer (GC) remains not well understood. This study investigated the expression of HLA-G in GC and the role of HLA-G-effected NK cells in GC progression. METHODS: HLA-G expression in GC tissues obtained from 49 patients with GC was analyzed by immunohistochemistry and western blot...
December 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29217401/influence-of-correlation-between-hla-g-polymorphism-and-interleukin-6-il6-gene-expression-on-the-risk-of-schizophrenia
#4
Venkataram Shivakumar, Monojit Debnath, Deepthi Venugopal, Ashwini Rajasekaran, Sunil V Kalmady, Manjula Subbanna, Janardhanan C Narayanaswamy, Anekal C Amaresha, Ganesan Venkatasubramanian
Converging evidence suggests important implications of immuno-inflammatory pathway in the risk and progression of schizophrenia. Prenatal infection resulting in maternal immune activation and developmental neuroinflammation reportedly increases the risk of schizophrenia in the offspring by generating pro-inflammatory cytokines including IL-6. However, it is not known how prenatal infection can induce immuno-inflammatory responses despite the presence of immuno-inhibitory Human Leukocyte Antigen-G (HLA-G) molecules...
December 4, 2017: Cytokine
https://www.readbyqxmd.com/read/29217368/hla-g-a-haplotypes-in-amerindians-ecuador-hla-g%C3%A2-01-05n-world-distribution
#5
Antonio Arnaiz-Villena, Jose Palacio-Gruber, Mercedes Enriquez de Salamanca, Ignacio Juárez, Cristina Campos, Jorge Nuñez, Ester Muñiz, Jose Manuel Martin-Villa
HLA-G and HLA-A frequencies have been analysed in Amerindians from Ecuador. HLA-G allele frequencies are found to be closer to those of other Amerindians (Mayas from Guatemala and Uros from Peru) and closer to European ones than to Far East Asians groups, particularly, regarding to HLA-G∗ 01:04 allele. HLA-G/-A haplotypes have been calculated for the first time in Amerindians. It is remarkable that HLA-G∗01:05N "null" allele is found in a very low frequency (like in Amerindian Mayas and Uros) and is also found in haplotypes belonging to the HLA-A19 group of alleles (HLA-A∗30, -A∗31,-A∗33)...
December 4, 2017: Human Immunology
https://www.readbyqxmd.com/read/29198970/the-choriocarcinoma-cell-line-jeg-3-upregulates-regulatory-t-cell-phenotypes-and-modulates-pro-inflammatory-cytokines-through-hla-g
#6
Wenna Nascimento Melsted, Sara Hyldig Matzen, Mads Hald Andersen, Thomas Vauvert F Hviid
An understanding of the interactions between immune cells and trophoblast cells, as well as choriocarcinoma cells, are of extreme importance in reproductive immunology and cancer immunology. In this study, we found that the human HLA-G-positive choriocarcinoma cell line JEG-3 upregulates CD4+CD25hiCD127lo T cells, increases the expression of HLA-G+CD4+ and CD8+ T cells, and decreases the expression of ILT2+ on CD4+ T cells in resting PBMCs after six days of co-culture. Expression of HLA-G on JEG-3 cells did not affect regulatory T cell phenotypes, but promoted modulation of pro-inflammatory cytokines IFN-γ, TNF-α and IL-17A...
November 30, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29196996/inflammatory-and-immune-system-markers
#7
Kelly J McKelvey, Gaayathri Ariyakumar, Sharon A McCracken
Since preeclampsia was first described by Hippocrates in 400 BC, the theory of its causation has shifted from toxins to a current theory that incorporates both vascular and immunological causation. Poor placentation whether it is genetically predisposed or due to low expression of defective HLA-G on fetal trophoblasts is believed to be the initial insult. Oxidative stress from placental ischemia/hypoxia leads to an overload of trophoblast debris by stimulating apoptosis or necrosis. Partial failure of the maternal immune system to tolerate the paternal alloantigens activates maternal immune cells to secrete cytokines whose pleiotropic functions lead to dysfunction of the maternal vascular and placental endothelium, blood coagulation, and fibrinolytic system...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29186714/enhanced-immunological-tolerance-by-hla-g1-from-neural-progenitor-cells-npcs-derived-from-human-embryonic-stem-cells-hescs
#8
Hong-Xi Zhao, Feng Jiang, Ya-Jing Zhu, Li Wang, Ke Li, Yang Li, Xiao-Hong Wang, Ling-Song Li, Yuan-Qing Yao
BACKGROUND: Despite the great potential of utilizing human embryonic stem cells (hESCs)-derived cells as cell source for transplantation, these cells were often rejected during engraftment by the immune system due to adaptive immune response. METHODS: We first evaluated HLA-G expression level in both hESCs and differentiated progenitor cells. After that, we generated modified hESC lines that over-express HLA-G1 using lentiviral infection with the construct contains both HLA-G1 and GFP tag...
November 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29156872/plasma-human-leukocyte-antigen-g-hla-g-in-patients-with-thyroid-cancer
#9
Murat Akın, Latife Arzu Aral, Aydın Yavuz, Harun Karabacak, Kürşat Dikmen, Hasan Bostancı
Background/aim: A number of tumor markers detected in the serum or pathological specimens using immunohistochemical methods are used for early detection of malignancies and postoperative follow-up. Human leukocyte antigen-G (HLA-G) is a nonclassic HLA class I molecule. Recent studies suggested a relationship between HLA-G positivity and the stage or the phenotype of the malignancy. In this study, the relationship between serum HLA-G positivity and thyroid cancer was investigated. Materials and methods: Fifty patients with thyroid cancer and 45 healthy volunteers were included in this study...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152919/characterisation-of-the-novel-hla-g-null-allele-hla-g-01-21n-in-finnish-individuals
#10
M-C Faucher, K Louvanto, S Syrjänen, M Roger
We identified the novel HLA-G*01:21N null allele in Finnish Caucasian individuals.
November 20, 2017: HLA
https://www.readbyqxmd.com/read/29150484/correction-for-bortolotti-et-al-pseudomonas-aeruginosa-quorum-sensing-molecule-n-3-oxododecanoyl-l-homoserine-lactone-induces-hla-g-expression-in-human-immune-cells
#11
Daria Bortolotti, Joel LeMaoult, Claudio Trapella, Dario Di Luca, Edgardo D Carosella, Roberta Rizzo
No abstract text is available yet for this article.
December 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29131154/impact-of-hla-g-polymorphism-on-the-outcome-of-allogeneic-hematopoietic-stem-cell-transplantation-for-metastatic-renal-cell-carcinoma
#12
R Crocchiolo, O Ringden, J-O Bay, D Blaise, B Omasic, B Mazzi, C Picard, S Trinca, L Barkholt, J Peccatori, S Gregori, G Amodio, K Fleischhauer, F Ciceri, M Bregni
Renal cell carcinoma (RCC) is particularly sensitive to immune intervention. HLA-G, a non-classical HLA class I molecule with immunomodulatory properties, has been studied with regard to outcome after hematopoietic stem cell transplantation (HSCT), in particular the 14 bp insertion/deletion polymorphism in the 3' untranslated region. Here we analyzed n=56 patients affected by metastatic RCC who received an allogeneic HSCT between 1998 and 2006 in Milano, Marseille, Clermont-Ferrand and Stockholm. The 14 bp polymorphism was analyzed in correlation with overall survival (OS), PFS, acute and chronic GvHD...
November 13, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29113092/recipient-hla-g-3142-cc-genotype-and-concentrations-of-soluble-hla-g-impact-on-occurrence-of-cmv-infection-after-living-donor-kidney-transplantation
#13
Hana Guberina, Rafael Tomoya Michita, Sebastian Dolff, Anja Bienholz, Mirko Trilling, Falko M Heinemann, Peter A Horn, Andreas Kribben, Oliver Witzke, Vera Rebmann
The expression modulation of the immunosuppressive non-classical Human leukocyte antigen-G (HLA-G) molecule and its soluble isoforms is an immune evasion strategy being deployed by cytomegalovirus (CMV). The +3142 C>G single nucleotide polymorphism (SNP) located within the 3' untranslated region (3'UTR) is of crucial importance for the regulation of HLA-G expression. Therefore, we analyzed the influence of the +3142 C>G HLA-G SNP on the occurrence of CMV infection in a cohort of 178 living-donor kidney recipients and their 178 corresponding donors...
November 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29105301/the-maternal-14%C3%A2-bp-ins-del-polymorphism-in-hla-g-is-not-associated-with-preeclampsia-risk
#14
L C Ferreira, T P B Lopes, T B Guimarães, C E M Gomes, S M B Jeronimo
The effect of HLA-G 14 bp Ins/Del polymorphism (rs371194629) on the risk of preeclampsia has been assessed in several populations, yet the results are still conflicting. Lack of power due to small sample sizes is a common cause of inconsistencies in genetic association studies. We aimed to test whether the maternal polymorphism is associated with preeclampsia, eclampsia or HELLP syndrome (acronym for Hemolysis, Elevation of Liver enzymes, Low Platelets). To achieve a statistical power greater than 0.90, a total of 741 women (332 controls, 246 preeclampsia, 57 eclampsia and 106 HELLP) were genotyped for the 14-bp Ins/Del polymorphism...
November 3, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29077717/a-polymorphism-in-the-haptoglobin-haptoglobin-related-protein-locus-is-associated-with-risk-of-human-sleeping-sickness-within-cameroonian-populations
#15
Elvis Ofon, Harry Noyes, Julius Mulindwa, Hamidou Ilboudo, Martin Simuunza, Vincent Ebo'o, Flobert Njiokou, Mathurin Koffi, Bruno Bucheton, Pythagore Fogue, Christiane Hertz-Fowler, Annette MacLeod, Gustave Simo
BACKGROUND: Human African Trypanosomiasis (HAT) is a neglected disease targeted for elimination as a public health problem by 2020. Elimination requires a better understanding of the epidemiology and clinical evolution of HAT. In addition to the classical clinical evolution of HAT, asymptomatic carriers and spontaneous cure have been reported in West Africa. A genetic component to human susceptibility to HAT has been suggested to explain these newly observed responses to infection. In order to test for genetic associations with infection response, genetic polymorphism in 17 genes were tested (APOL1, IL1B, IL4, IL4R, IL6, IL8, IL12B, IL12RB1, IL10, TNFA, INFG, MIF, HLA-G, HLA-A, HP, HPR and CFH)...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29076586/cancer-and-normal-adipose-derived-mesenchymal-stem-cells-ascs-do-they-have-differential-effects-on-tumor-and-immune-cells
#16
Mahboobeh Razmkhah, Zahra Mansourabadi, Maryam Al-Sadat Mohtasebi, Abdol-Rasoul Talei, Abbas Ghaderi
Adipose-derived mesenchymal stem cells (ASCs) are known to have immunomodulatory properties through soluble factors or by direct cell-to-cell contact. This study aimed to assess the expression of HLA-G and IDO activity in breast cancer and normal ASCs and to see if ASC is capable of modulating both tumor cells and immune system cells in vitro. ASCs were enzymatically isolated from 15 breast cancer patients and 10 normal individuals. Then they were cultured, and the impact of their conditioned media on the movement of the MDA-MB-231 breast cancer cell line was studied in wound healing scratch assay...
October 27, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29073617/preimplantation-factor-pif-promotes-hla-g-e-f-c-expression-in-jeg-3-choriocarcinoma-cells-and-endogenous-progesterone-activity
#17
Miya Soukaina Hakam, Jose Maria Miranda-Sayago, Soren Hayrabedyan, Krassimira Todorova, Patrick Simon Spencer, Asma Jabeen, Eytan R Barnea, Nelson Fernandez
BACKGROUND/AIMS: Pregnancy success requires mandatory maternal tolerance of the semi/ allogeneic embryo involving embryo-derived signals. Expression levels of PreImplantation Factor (PIF), a novel peptide secreted by viable embryos, correlate with embryo development, and its early detection in circulation correlates with a favourable pregnancy outcome. PIF enhances endometrial receptivity to promote embryo implantation. Via the p53 pathway, it increases trophoblast invasion, improving cell survival / immune privilege...
October 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29067119/mir-148a-modulates-hla-g-expression-and-influences-tumor-apoptosis-in-esophageal-squamous-cell-carcinoma
#18
Quan Chen, Guanghua Luo, Xiaoying Zhang
Esophageal cancer (EC) is a common malignant tumor type, and esophageal squamous cell carcinoma (ESCC) accounts for the majority of EC cases. Previous studies have reported that microRNA (miR)-148a is downregulated in patients with recurrent EC. The human leukocyte antigen-G (HLA-G) is expressed to a high level in primary ESCC tissues and is associated with prognosis. A previous luciferase assay indicated that HLA-G is a target of miR-148a regulation. The aim of the current study was to investigate the expression level of miR-148a in primary ESCC...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29061057/analysis-of-hla-g-gene-polymorphisms-in-slovak-women-with-pre-eclampsia
#19
V Durmanova, J Drobny, I Shawkatova, J Dlhopolcek, M Bucova
OBJECTIVES: To identify possible association between the selected HLA-G gene polymorphisms and risk of pre-eclampsia. BACKGROUND: Pre-eclampsia is a serious multisystem disorder that affects women during pregnancy. Despite many research studies, the pathology of pre-eclampsia is not fully understood. Human leukocyte antigen G (HLA-G) belongs to the molecules that induce fetal acceptance by the maternal immune system. HLA-G expression was found to be impaired in the women suffering from pre-eclampsia suggesting its involvement in the development of pre-eclampsia...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29059176/candidate-genes-based-investigation-of-susceptibility-to-human-african-trypanosomiasis-in-c%C3%A3-te-d-ivoire
#20
Bernardin Ahouty, Mathurin Koffi, Hamidou Ilboudo, Gustave Simo, Enock Matovu, Julius Mulindwa, Christiane Hertz-Fowler, Bruno Bucheton, Issa Sidibé, Vincent Jamonneau, Annette MacLeod, Harry Noyes, Simon-Pierre N'Guetta
Human African Trypanosomiasis (HAT) or sleeping sickness is a Neglected Tropical Disease. Long regarded as an invariably fatal disease, there is increasing evidence that infection by T. b. gambiense can result in a wide range of clinical outcomes, including latent infections, which are long lasting infections with no parasites detectable by microscopy. The determinants of this clinical diversity are not well understood but could be due in part to parasite or host genetic diversity in multiple genes, or their interactions...
October 2017: PLoS Neglected Tropical Diseases
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