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https://www.readbyqxmd.com/read/28088953/-research-of-mhla-g-and-the-receptor-expression-with-kidney-rejection-and-cmv-active-infection-following-kidney-transplantation
#1
L L Bi, Y Gao, Y J Sun, X R Kong, X Y He, X H Ma, W H Zhang, L Xiao, B Y Shi
Objective: To study the expression of membrane HLA-G (mHLA-G) and the receptor immunoglobulin-like transcript 2(ILT2) on lymphocyte and find their association with rejection and cytomegalovirus (CMV) infection after renal transplantation. Methods: A total of 88 cases of renal transplant recipients for the first time from February 2014 to February 2016 were studied in this work. Recipients can be divided into rejection group (n=12) and stable renal function group (n=41) according to whether rejection occurred...
January 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28052009/cancer-associated-fibroblasts-promote-an-immunosuppressive-microenvironment-through-the-induction-and-accumulation-of-protumoral-macrophages
#2
Hideyuki Takahashi, Koichi Sakakura, Takeshi Kudo, Minoru Toyoda, Kyoichi Kaira, Tetsunari Oyama, Kazuaki Chikamatsu
Stromal cells in the tumor microenvironment (TME) closely interact with tumor cells and affect tumor cell behavior in diverse manners. We herein investigated the mechanisms by which cancer-associated fibroblasts (CAFs) affect the functional polarization of tumor-associated macrophages (TAMs) in oral squamous cell carcinoma (OSCC) in vitro and in human cancer samples. The expression of CD68, CD14, CD163, CD200R, CD206, HLA-G, CD80, and CD86 was higher in CD14-positive cells co-cultured with the culture supernatants of CAFs established from OSCC specimens (CAF-educated cells) than in control cells...
December 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/28045999/haplotypes-of-the-hla-g-3-untranslated-region-respond-to-endogenous-factors-of-hla-g-and-hla-g-cell-lines-differentially
#3
Isabelle Poras, Layale Yaghi, Gustavo Martelli-Palomino, Celso T Mendes-Junior, Yara Costa Netto Muniz, Natalia F Cagnin, Bibiana Sgorla de Almeida, Erick C Castelli, Edgardo D Carosella, Eduardo A Donadi, Philippe Moreau
The immune checkpoint HLA-G prevents maternal rejection of the fetus and contributes in cancer invasion and acceptance of allografts. The 5' and 3' regulatory regions of the HLA-G gene are polymorphic and balancing selection probably maintains this variability. It is proposed that nucleotide variations may affect the level of HLA-G expression. To investigate this issue we aimed to analyze how haplotypes of the 3' untranslated region (3'UTR) with highest worldwide frequencies, namely UTR-1, UTR-2, UTR-3, UTR-4, UTR-5, UTR-18 and UTR-7, impact the expression of a luciferase reporter gene in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28041834/the-hla-g-14-base-pair-deletion-allele-and-the-deletion-deletion-genotype-are-associated-with-persistent-hbe-antigenemia-in-chronic-hepatis-b-infection
#4
Sandro da Costa Ferreira, Silvana Gama Florêncio Chachá, Fernanda Fernandes Souza, Andreza Corrêa Teixeira, Rodrigo de Carvalho Santana, Neifi Hassan Saloun Deghaide, Sandra Rodrigues, Leonardo A Marano, Celso Teixeira Mendes-Junior, Leandra Naira Zambelli Ramalho, Sérgio Zucoloto, Eduardo Antônio Donadi, Ana de Lourdes Candolo Martinelli
BACKGROUND AND AIMS: HLA-G has well-recognized immunomodulatory properties, and this molecule is frequently expressed in the livers of hepatitis B virus (HBV)-infected patients. Because the HLA-G 14 bp-insertion/deletion polymorphism (rs371194629) has been associated with the magnitude of HLA-G expression, we evaluated this polymorphism in the recognized evolutionary forms of chronic HBV infection. METHODS: We studied 196 chronic HBV-infected patients (118 HBeAg-negative chronic hepatitis, 53 HBeAg-positive chronic hepatitis and 25 inactive carriers exhibiting low levels of serum HBVDNA and persistently normal ALT levels), and 202 healthy individuals...
December 29, 2016: Human Immunology
https://www.readbyqxmd.com/read/28040535/promising-link-of-hla-g-polymorphism-tobacco-consumption-and-risk-of-head-and-neck-squamous-cell-carcinoma-hnscc-in-north-indian-population
#5
Vertica Agnihotri, Abhishek Gupta, Rahul Kumar, Ashish Datt Upadhyay, Sadanand Dwivedi, Lalit Kumar, Sharmistha Dey
Human leukocyte antigen (HLA-G) is a potent immune-tolerant molecule and has a critical role in various pathological conditions of cancer. The aim of the study was to analyze the association of HLA-G polymorphism as a risk factor in Head and Neck Squamous Cell Carcinoma (HNSCC). The HLA-G polymorphism at 3'UTR 14bp INDEL (rs371194629) and +3142G/C (rs1063320) were studied in 383 HNSCC patients and 383 ethnically similar-aged healthy controls in North Indian population. The genotyping study of two polymorphisms of HLA-G was documented using DNA-PAGE and RFLP-PCR method...
December 28, 2016: Human Immunology
https://www.readbyqxmd.com/read/27999823/the-pathophysiological-impact-of-hla-class-ia-and-hla-g-expression-and-regulatory-t-cells-in-malignant-melanoma-a-review
#6
REVIEW
Lasse Lindholm Johansen, Jørgen Lock-Andersen, Thomas Vauvert F Hviid
Malignant melanoma, a very common type of cancer, is a rapidly growing cancer of the skin with an increase in incidence among the Caucasian population. The disease is seen through all age groups and is very common in the younger age groups. Several studies have examined the risk factors and pathophysiological mechanisms of malignant melanoma, which have enlightened our understanding of the development of the disease, but we have still to fully understand the complex immunological interactions. The examination of the interaction between the human leucocyte antigen (HLA) system and prognostic outcome has shown interesting results, and a correlation between the down- or upregulation of these antigens and prognosis has been seen through many different types of cancer...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27998803/a-pilot-study-on-hla-g-locus-control-region-haplotypes-and-cervical-intraepithelial-neoplasias
#7
Juliana Cochesnki Cordeiro, Jose Samuel da Silva, Valeria Sperandio Roxo, Maria da Graça Bicalho
Human papillomavirus (HPV) can induce cervical intraepithelial neoplasias (CIN) grades 1, 2 and 3. Untreated, these lesions may progress to cervical cancer (CC) which is the third most common cancer in women worldwide. HLA-G plays an immunotolerant role in the immune response. The aim of this study was to characterize the configuration of SNPs located at the distal promoter of HLA-G in patients with CIN2 and CIN3 and control women. The study sample was composed of 207 women as follows: 73 diagnosed with CIN2 lesions, 56 with CIN3 and 78 healthy control women...
December 17, 2016: Human Immunology
https://www.readbyqxmd.com/read/27996960/recombinant-vascular-endothelial-growth-factor-121-injection-for-the-prevention-of-fetal-growth-restriction-in-a-preeclampsia-mouse-model
#8
Sri Sulistyowati, Muhammad Adrianes Bachnas, Nuri Dyah Anggraini, Eric Edwin Yuliantara, Wisnu Prabowo, Nutria Widya Purna Anggraini, Mochammad Besari Adi Pramono, Adityawarman, Erry Gumilar Dachlan, Wiku Andonotopo
AIM: To discover the potential role of recombinant VEGF121 (rVEGF121) injection for the prevention of fetal growth restriction in a preeclampsia (PE) mouse model (Mus musculus). SUBJECTS AND METHODS: This is an experimental study of 30 pregnant mice that were randomly divided into three groups: normal, PE, and PE with rVEGF121 injection. The PE mouse model was created by injecting anti Qa-2 10 ng iv, which is deleterious to Qa-2 expression (homologous to HLA-G), from the first to the fourth day of gestation...
December 10, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27984763/soluble-hla-g-concentrations-in-obese-women-during-pregnancy-and-in-cord-blood
#9
Fausta Beneventi, Elena Locatelli, Mara De Amici, Miryam Martinetti, Arsenio Spinillo
CONTEXT: Little is known about soluble HLA-G (sHLA-G) concentrations in obese pregnant women with uncomplicated pregnancies. OBJECTIVE: To investigate the role of sHLA-G in obese pregnancies. DESIGN: Case-control study, from 2013 to 2015. SETTING: A tertiary care centre. PATIENTS: 168 healthy normal weight women and 59 overweight/obese women; to avoid the effect of preeclampsia on sHLA-G concentrations, cases were further divided in two groups: 42 with normotensive pregnancy and 17 who developed preeclampsia...
November 24, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27969076/the-impact-of-il10-polymorphisms-and-shla-g-levels-on-the-risk-of-schizophrenia
#10
Ashwini Rajasekaran, Venkataram Shivakumar, Sunil V Kalmady, Janardhanan C Narayanaswamy, Manjula Subbana, Deepthi Venugopal, Anekal C Amaresha, Ganesan Venkatasubramanian, Monojit Debnath
Early life immune aberrations have strongly been associated with the risk of schizophrenia. Amongst them, inflammation induced neurodevelopmental origin has emerged as one of the widely recognized underlying mechanisms. Interleukin-10 (IL-10) is an important anti-inflammatory and immunoregulatory cytokine. It modulates the expression of another immuno-inhibitory molecule, Human Leukocyte Antigen-G (HLA-G), predominantly expressed at the feto-maternal interface. Under physiological conditions, IL-10 and HLA-G molecules regulate the feto-maternal immune homeostasis by limiting the inflammatory states and influence the outcome of pregnancy...
October 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27914217/hla-g-3-untranslated-region-polymorphic-sites-associated-with-increased-hla-g-production-are-more-frequent-in-patients-exhibiting-differentiated-thyroid-tumors
#11
Nathalie Lobo de Figueiredo-Feitosa, Gustavo Martelli Palomino, Daiani Cristina Cilião Alves, Celso Teixeira Mendes Junior, Eduardo Antonio Donadi, Léa Maria Zanini Maciel
BACKGROUND: HLA-G is a non-classical class I histocompatibility molecule implicated on the immune escape mechanism of tumor cells. We evaluated the genetic diversity of HLA-G 3' untranslated region (3'UTR) and associated polymorphic sites with clinical presentation and with the magnitude of HLA-G thyroid expression. PATIENTS AND METHODS: Polymorphic sites at 3'UTR (14bpINS/DEL, +3003C/T, +3010C/G, +3027A/C, +3035C/T, +3142C/G, +3187A/G, +3196C/G) were characterized by sequencing analyses in blood samples of 72 patients exhibiting papillary thyroid carcinoma (PTC), 22 follicular thyroid carcinomas (FTC), 19 follicular adenomas (FA), 21 colloid goiters and 156 healthy controls...
December 2, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27895918/classical-and-non-classical-hla-class-i-aberrations-in-primary-cervical-squamous-and-adenocarcinomas-and-paired-lymph-node-metastases
#12
Debbie M Ferns, A Marijne Heeren, Sanne Samuels, Maaike C G Bleeker, Tanja D de Gruijl, Gemma G Kenter, Ekaterina S Jordanova
BACKGROUND: Tumors avoid destruction by cytotoxic T cells (CTL) and natural killer (NK) cells by downregulation of classical human leukocyte antigens (HLA) and overexpression of non-classical HLA. This is the first study to investigate HLA expression in relation to histology (squamous cell carcinoma (SCC) vs. adenocarcinoma (AC)), clinicopathological parameters and survival in a large cervical cancer patient cohort. METHODS: Classical (HLA-A and HLA-B/C)- and non-classical HLA molecules (HLA-E and HLA-G) were studied on primary tumors and paired lymph node (LN) metastases from cervical cancer patients (n = 136) by immunohistochemistry...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27880031/increased-levels-of-plasma-soluble-human-leukocyte-antigen-g-in-persistent-wheezy-infants
#13
Fulya Tahan, Hatice Eke Gungor, Himmet Haluk Akar, Berkay Saraymen
BACKGROUND: Human leukocyte antigen (HLA)-G is a non-classical major histocompatibility complex (MHC) class I antigen characterized by limited polymorphism in its coding region, unique tissue expression pattern in physiologic conditions and immunomodulatory properties. Recently, many studies suggest that the levels of sHLA-G were higher in atopic asthma and allergic rhinitis (AR). However, this remains to be uncertain in wheezy infants. In the present study, it was aimed to determine sHLA-G levels in wheezy infants...
November 23, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27859042/hla-g-promotes-myeloid-derived-suppressor-cell-accumulation-and-suppressive-activity-during-human-pregnancy-through-engagement-of-the-receptor-ilt4
#14
Natascha Köstlin, Anna-Lena Ostermeir, Bärbel Spring, Julian Schwarz, Alexander Marmé, Christina B Walter, Christian F Poets, Christian Gille
Establishing and maintaining maternal-fetal tolerance is essential for a successful pregnancy; failure of immunological adaptation to pregnancy leads to severe complications such as abortion or preterm delivery. Myeloid-derived suppressor cells (MDSCs) are innate immune cells that suppress T-cell responses, expand during pregnancy and thus may play a role in tolerance induction. Human leucocyte antigen G (HLA-G) is a major histocompatibility complex (MHC) I molecule with immune-modulatory properties, which is expressed during pregnancy...
November 10, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27835619/hla-g-hiv-1-specific-cd8-t-cells-are-associated-with-hiv-1-immune-control
#15
Selena Viganò, Jordi J Negrón, Samantha Tse, Fatema Z Chowdhury, Mathias Lichterfeld, Xu G Yu
OBJECTIVE(S): To assess the frequency and function of HIV-1-specific HLA-G (histocompatibility antigen class I, G) CD8 T cells in HIV-1 controllers and progressors. DESIGN: We performed an observational cross-sectional cohort analysis in untreated (n = 47) and treated (n = 17) HIV-1 patients with different rates of disease progression and n = 14 healthy individuals. METHODS: We evaluated the frequency, the proportion and the function of total and virus-specific HLA-G CD8 T cells by tetramer or intracellular cytokine staining, followed by flow cytometric analysis...
January 14, 2017: AIDS
https://www.readbyqxmd.com/read/27833846/mesenchymal-stromal-cells-derived-from-whole-human-umbilical-cord-exhibit-similar-properties-to-those-derived-from-wharton-s-jelly-and-bone-marrow
#16
Claire Mennan, Sharon Brown, Helen McCarthy, Eleni Mavrogonatou, Dimitris Kletsas, John Garcia, Birender Balain, James Richardson, Sally Roberts
Mesenchymal stromal cells (MSC) can be isolated from several regions of human umbilical cords, including Wharton's jelly (WJ), artery, vein or cord lining. These MSC appear to be immune privileged and are promising candidates for cell therapy. However, isolating MSC from WJ, artery, vein or cord lining requires time-consuming tissue dissection. MSC can be obtained easily via briefly digesting complete segments of the umbilical cord, likely containing heterogenous or mixed populations of MSC (MC-MSC). MC-MSC are generally less well characterized than WJ-MSC, but nevertheless represent a potentially valuable population of MSC...
November 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27820781/inhibition-of-t-cell-alloreactivity-by-bronchial-epithelium-is-impaired-in-lung-transplant-recipients-through-pathways-involving-tgf-%C3%AE-il-10-and-hla-g
#17
C Dupin, E Lhuillier, S Létuvé, M Pretolani, G Thabut, H Mal, E D Carosella, C Schilte, P Mordant, V Bunel, C Danel, N Rouas-Freiss, O Brugière
BACKGROUND: Bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTx) results from bronchial epithelial cell (BECs) damages, thought to be orchestrated by T cells primed by antigen-presenting cell (APC) presenting allo-antigens. In this cell cross-talk, BECs are also suspected to play a pivotal immunosuppressive role in T cell alloreactivity. We studied the immunomodulating role of BECs in a human ex-vivo model of allogeneic T cell response, both in healthy subjects and LTx recipients...
November 3, 2016: Transplantation
https://www.readbyqxmd.com/read/27812316/common-genetic-variants-found-in-hla-and-kir-immune-genes-in-autism-spectrum-disorder
#18
REVIEW
Anthony R Torres, Thayne L Sweeten, Randall C Johnson, Dennis Odell, Jonna B Westover, Patricia Bray-Ward, David C Ward, Christopher J Davies, Aaron J Thomas, Lisa A Croen, Michael Benson
The "common variant-common disease" hypothesis was proposed to explain diseases with strong inheritance. This model suggests that a genetic disease is the result of the combination of several common genetic variants. Common genetic variants are described as a 5% frequency differential between diseased vs. matched control populations. This theory was recently supported by an epidemiology paper stating that about 50% of genetic risk for autism resides in common variants. However, rare variants, rather than common variants, have been found in numerous genome wide genetic studies and many have concluded that the "common variant-common disease" hypothesis is incorrect...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27806848/a-comparison-of-cancer-stem-cell-markers-and-nonclassical-major-histocompatibility-complex-antigens-in-colorectal-tumor-and-noncancerous-tissues
#19
Rabia Bilge Özgül Özdemir, Alper Tunga Özdemir, Fatih Oltulu, Kamile Kurt, Gürkan Yiğittürk, Cengiz Kırmaz
Colorectal carcinoma (CRC) is one of the most fatal types of cancer in both women and men, and, unfortunately, patients are often diagnosed at an advanced stage. Cancer stem cells (CSCs) are associated with poor prognosis, metastasis, and recurrence, as well as chemotherapy and radiotherapy resistance. Therefore, different treatment alternatives are needed to facilitate the elimination of CSCs. One such approach is immunotherapy; however, tumor cells can evade immune cells by alteration of the expression patterns of human leukocyte antigens (HLA)...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27800497/upregulation-of-soluble-hla-g-in-chronic-left-ventricular-systolic-dysfunction
#20
Line Lisbeth Olesen, Thomas Vauvert F Hviid
Left ventricular systolic dysfunction (LVSD) defined by ejection fraction (EF) <40% is common, serious but treatable, and correct diagnosis is the cornerstone of effective treatment. Biomarkers may help to diagnose LVSD and give insight into the pathophysiology. The immune system is activated in LVSD, and the immunomodulatory molecule human leukocyte antigen-G (HLA-G) may be involved. The primary aim was to measure soluble HLA-G (sHLA-G) in the blood in different stages of LVSD (<30% and 30-40%), in the midrange EF 40-50%, and in preserved EF ≥ 50% and to validate sHLA-G as a LVSD biomarker...
2016: Journal of Immunology Research
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