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https://www.readbyqxmd.com/read/27910995/a-diffusion-tensor-magnetic-resonance-imaging-study-of-paediatric-patients-with-severe-non-traumatic-brain-injury
#1
Erika Molteni, Maria A Rocca, Sandra Strazzer, Elisabetta Pagani, Katia Colombo, Filippo Arrigoni, Giacomo Boffa, Massimiliano Copetti, Valentina Pastore, Massimo Filippi
AIM: In this observational study using 3T magnetic resonance imaging (MRI) and diffusion tensor, we investigated the differential effects of pathology, stage of disease, state of consciousness, and aetiology on the modifications of supra- and infra-tentorial white matter tracts and their correlations with clinical scales in paediatric patients with severe non-traumatic brain injury. METHOD: Diffusion tensor magnetic resonance imaging (DT-MRI) was obtained from seven children with unresponsive wakefulness syndrome (UWS; five males, two females; age at event 5y; standard deviation [SD] 2y 1mo), six children in a minimally conscious state (MCS; three males, three females; age at event 5y 10mo; SD 5y), and 10 healthy children as controls(two males, eight females; age at study 10y 10mo; SD 2y 10mo)...
December 2, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27891787/evaluation-of-the-western-australian-register-of-developmental-anomalies-thirty-five-years-of-surveillance
#2
Wendy N Nembhard, Carol Bower
BACKGROUND: The birth defects component of the Western Australian Register for Developmental Anomalies (WARDA-BD) was evaluated to assess its efficiency, effectiveness, and data quality. METHODS: WARDA-BD was evaluated using the Centers for Disease Control and Prevention Guidelines for Evaluating Public Health Surveillance Systems and Data Quality Standards from the National Birth Defects Prevention Network. The evaluation included interviews with Register staff, local community organizations, parents, clinicians, and researchers; process observation; and secondary data analyses...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27867854/laparoscopic-extravesical-ureteral-reimplantation-levur-a-systematic-review
#3
REVIEW
Alessandra Farina, Ciro Esposito, Maria Escolino, Manuel Lopez, Alessandro Settimi, François Varlet
BACKGROUND: Laparoscopic ureteral reimplantation is a feasible method for treating ureteral pathology with good preliminary results in the literature. In this study, we review medium term results for laparoscopic ureteral reimplantation and discuss current developments of this procedure. METHODS: Medline and Embase databases were searched using relevant key terms to identify reports of paediatric laparoscopic extravesical ureteral reimplantation (LEVUR). Literature reviews, case reports, series of <3 children and adult studies (age >20 years) were excluded...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27867845/current-management-of-non-palpable-testes-a-literature-review-and-clinical-results
#4
REVIEW
Ximena Sepúlveda, Pedro-José López Egaña
Cryptorchidism is a common pathology that occurs in 3% in full term newborns, and it decreases to 0.8-1.2% at 1 year of age. Nearly a 20% of undescended testes are non-palpable. Various surgical treatments have been described, but its management is still controversial. A literature review was made of non-palpable testes, analysing diagnostic tools, treatment and its results. Additionally we reviewed non-palpable testes cases treated in our centre in the last 20 years. Different techniques are described for the management of non-palpable testes; with or without section of the spermatic vessels and/or in 1 or 2 stages...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27863620/paediatric-airway-foreign-body-the-human-factors-influencing-patient-safety-in-our-hospitals
#5
O C Okonkwo, A Simons, J Nichani
Foreign bodies in the pediatric airway are an uncommon emergency with a high morbidity and mortality rate. Morbidity ranges from 10 to 20% worldwide and this pathology accounts for up to 7% of accidental deaths in children under 4. Dealing with this emergency safely and effectively is complex, requiring a tight coupling of procedures and processes and optimal anesthetic and operating conditions to prevent errors. These factors are recognized by the World Health Organization as 'Human Factors'. We perform a multi-center assessment of human factors pertinent to this emergency...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27858468/a-qualitative-comparison-of-arterial-spin-labelling-and-dynamic-susceptibility-contrast-mri-in-52-children-with-a-range-of-neurological-conditions
#6
Paul A Armitage, Nicholas Skipper, Daniel J A Connolly, Paul D Griffiths
OBJECTIVE: To assess the usefulness of Arterial Spin Labelling (ASL) compared with Dynamic Susceptibility Contrast (DSC) perfusion MRI for typical paediatric neuroimaging applications at 1.5 Tesla. METHODS: 52 children (age: 4 months - 17 years) with a variety of neurological disorders were scanned using 3D ASL and Echo Planar Imaging DSC sequences. All images were reviewed by an experienced neuroradiologist, image quality recorded as 'good', 'acceptable', or 'poor' and diagnostic value noted as being 'greater', 'similar' or 'less' for ASL when compared to DSC...
November 18, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27857244/a-pioneer-paediatrician-in-new-zealand-geoffrey-bruton-sweet-1-9-1870-17-5-1939-mb-chm-sydney-1893
#7
William J Sugrue, Patricia M Clarkson
Paediatrics as a specialty was slow to emerge in New Zealand where Geoffrey Bruton Sweet was a pioneer full-time paediatrician from 1907 to 1939. Although there had been appointments as paediatric lecturers to the Otago Medical School, the early appointees were not restricted to paediatric practice. Dr Sweet, an Australian graduate, came to New Zealand and made a major contribution to the development of pathology services before embarking on a career devoted to paediatrics. He was a powerful advocate for children, well read and interested in clinical research, and realised the need to communicate with those directly involved in the care of children...
November 18, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27847539/cyst-like-change-in-the-thyroid-cartilage-a-developmental-variant-in-children
#8
Karen Chetcuti, Shivaram Avula
Neck sonography is frequently encountered on ultrasound lists in the paediatric patient population. Anecdotally, one of the most frequent clinical indications is the investigation of a neck lump. While performing an ultrasound of the neck, structures other than those routinely assessed, such as the thyroid cartilage and mandibular cortex also come into view. Occasionally, pathology in these structures is also encountered, albeit less frequently. The purpose of this case report and review is to illustrate the ultrasound, computed tomography and magnetic resonance imaging appearances of cyst-like changes in the thyroid cartilage that are encountered in children, particularly in early adolescence...
November 2016: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/27818386/pediatric-necrotizing-myopathy-associated-with-anti-3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-antibodies
#9
Wen-Chen Liang, Akinori Uruha, Shigeaki Suzuki, Nobuyuki Murakami, Eri Takeshita, Wan-Zi Chen, Yuh-Jyh Jong, Yukari Endo, Hirofumi Komaki, Tatsuya Fujii, Yutaka Kawano, Madoka Mori-Yoshimura, Yasushi Oya, Jianying Xi, Wenhua Zhu, Chongbo Zhao, Yurika Watanabe, Keisuke Ikemoto, Atsuko Nishikawa, Kohei Hamanaka, Satomi Mitsuhashi, Norihiro Suzuki, Ichizo Nishino
OBJECTIVE: Antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) have recently been associated with immune-mediated necrotizing myopathy, especially in patients with statin exposure. As the data are very limited concerning phenotypes and treatment in paediatric patients, we aimed to identify the paediatric patients positive for anti-HMGCR antibodies and clarify their features and therapeutic strategies. METHODS: We screened 62 paediatric patients who were clinically and/or pathologically suspected to have inflammatory myopathy for anti-HMGCR antibodies...
November 6, 2016: Rheumatology
https://www.readbyqxmd.com/read/27807959/-an-example-of-the-integrated-use-of-administrative-health-databases-for-the-study-of-childhood-cancer-clusters
#10
Patrizia Schifano, Claudia Marino, Federica Asta, Manuela De Sario, Paola Michelozzi
We developed an algorithm to select incident cases of lymphatic and haematopoietic system in children, in order to create a timely and accurate database of incident cases to answer the needs of cluster analysis. This group of cancers is by far the most frequent in the paediatric age. The procedure has been applied to identify incident cases in children aged 0-14 years, resident in Rome (Central Italy), and diagnosed between 2000 and 2011. The algorithm links hospital discharge records (SDO), the hospital registry of the Italian Association of paediatric haematology and oncology (AIEOP), and the Population Registry...
September 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27806184/antifibrinolytic-therapy-to-reduce-haemoptysis-from-any-cause
#11
REVIEW
Gabriela Prutsky, Juan Pablo Domecq, Carlos A Salazar, Roberto Accinelli
BACKGROUND: Haemoptysis is a common pathology around the world, occurring with more frequency in low-income countries. It has different etiologies, many of which have infectious characteristics. Antifibrinolytic agents are commonly used to manage bleeding from different sources, but their usefulness in pulmonology is unclear. OBJECTIVES: To evaluate the effectiveness and safety of antifibrinolytic agents in reducing the volume and duration of haemoptysis in adult and paediatric patients...
November 2, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27801781/function-and-regulation-of-micrornas-and-their-potential-as-biomarkers-in-paediatric-liver-disease
#12
REVIEW
Diego A Calvopina, Miranda A Coleman, Peter J Lewindon, Grant A Ramm
MicroRNAs (miRNAs) are short non-coding RNAs involved in biological and pathological processes of every cell type, including liver cells. Transcribed from specific genes, miRNA precursors are processed in the cytoplasm into mature miRNAs and as part of the RNA-induced silencing complex (RISC) complex binds to messenger RNA (mRNA) by imperfect complementarity. This leads to the regulation of gene expression at a post-transcriptional level. The function of a number of different miRNAs in fibrogenesis associated with the progression of chronic liver disease has recently been elucidated...
October 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27784899/plasma-ang2-and-adam17-levels-are-elevated-during-clinical-malaria-ang2-level-correlates-with-severity-and-expression-of-epcr-binding-pfemp1
#13
Jens E V Petersen, Sixbert I Mkumbaye, Anna V Vaaben, Alphaxard Manjurano, Eric Lyimo, Reginald A Kavishe, Steven B Mwakalinga, Jacklin Mosha, Daniel T R Minja, John P A Lusingu, Thor G Theander, Thomas Lavstsen, Christian W Wang
The pathogenesis of Plasmodium falciparum malaria involves a complex interplay between parasite adhesion and inflammatory response that includes release of cytokines and activation of the endothelium with accompanying release of Angiopoitin 2 (Ang2) to the plasma. A-disintegrin and metalloproteinase 17 (ADAM17) is a protein responsible for releasing cytokines, including Tumor Necrosis Factor α (TNFα), and shedding of adhesion proteins. In this study, we show that plasma levels of ADAM17 are increased in Tanzanian children hospitalized with a malaria infection compared with asymptomatic children but similar to children hospitalized with other infectious diseases...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27783901/otoscopic-examinations-reveal-high-prevalence-of-outer-and-middle-ear-pathologies-in-paediatrics-in-limpopo-south-africa
#14
Mukovhe Chad Phanguphangu
OBJECTIVE: To determine the prevalence of outer and middle ear pathologies in paediatrics in Limpopo, South Africa. DESIGN: Cross-sectional retrospective review of otoscopy results obtained during a school health screening campaign conducted between March and June 2015. Descriptive statistics through percentages and frequency tables were used to analyse the data. Logistic regression was used to determine associations between age, gender and pathologies observed...
October 26, 2016: International Journal of Audiology
https://www.readbyqxmd.com/read/27780309/incidental-inflammatory-adenoma-with-%C3%AE-catenin-activation-in-the-setting-of-paediatric-nash
#15
S Oliveira, A K Samba, A J Towbin, A Gupta, J I Geller, J D Nathan, R Kohli
: Hepatocellular adenomas (HCA) are benign tumours with potential for malignant transformation with no recommendations regarding management in the paediatric population. We report a case of an inflammatory adenoma with β-catenin activated pathway in an obese, paediatric patient with nonalcoholic steatohepatitis (NASH). CASE REPORT: An 11-year-old female presented with a microlobulated liver lesion measuring >5 cm in magnetic resonance imaging (MRI) with inflammatory adenoma with β-catenin activated pathology arising in a background of NASH, nonalcoholic fatty liver disease (NAFLD) activity score 5/8...
October 25, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27780149/nanofibrous-bioengineered-heart-valve-application-in-paediatric-medicine
#16
REVIEW
Mehrdad Namdari, Ali Eatemadi
Heart valves are currently under thorough investigation in tissue engineering (TE) research. Mechanical and biological heart valve prostheses which are recently used have several shortcomings. While allogenic and xenogenic biological prostheses are related to graft rejection, degeneration and thrombosis, resulting in a high rate of reoperation. Mechanical prostheses on the other hand are based on metallic, carbon, and polymeric components, and require continuous treatment with anticoagulant, which result in adverse reactions, e...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27779314/co-sleeping-in-school-aged-children-with-a-motor-disability-a-comparative-population-based-study
#17
David Jacquier, Christopher John Newman
AIM: To determine the prevalence and determinants of co-sleeping in school-aged children with a motor disability compared with the school-aged general population. METHOD: A questionnaire on demographic characteristics and co-sleeping habits, along with the Sleep Disturbance Scale for Children (SDSC), was sent to parents of children aged between 4 years and 18 years followed in our tertiary paediatric neurorehabilitation clinic, and to school-aged children in a representative sample of state schools...
October 25, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27775301/-is-there-appendiceal-stump-appendicitis
#18
A García Baglietto, C Barceló Cañellas, C Marhuenda Irastorza
INTRODUCTION: Stump appendicitis is the remaining appendicular tissue inflammation after a variable length of time. It is a very infrequent pathology with a paucity in pediatric publications, and given the fact that a delay in its diagnosis could lead to an increased morbidity, this is the reason of its clinical relevance. CLINICAL CASE: A 10 years old girl who had laparoscopic excision of a flemonous-gangrenous appendicitis and who 45 days after surgery showed new clinical symptoms compatible with a diagnosis of acute appendicitis...
October 10, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27761882/lesions-involving-the-outer-surface-of-the-bone-in-children-a-pictorial-review
#19
REVIEW
Apeksha Chaturvedi, R A C Dilhani Ranasinghe, Abhishek Chaturvedi, Steven P Meyers
BACKGROUND: Lesions involving the outer cortical surface of the bone occur quite often among children. Broadly, these include benign cortical, juxtacortical and periarticular lesions, dysplasias affecting the cortical bone, regional and diffuse periosteal pathology and malignant tumours. Some of these lesions are unique to the paediatric population; others are more frequently seen among children than adults - yet others have an adult predilection but can occasionally be seen in children...
December 2016: Insights Into Imaging
https://www.readbyqxmd.com/read/27716155/specialty-preferences-among-final-year-medical-students-in-medical-schools-of-southeast-nigeria-need-for-career-guidance
#20
Edmund Ndudi Ossai, Kenechi Anderson Uwakwe, Uchenna Chidi Anyanwagu, Ntat Charles Ibiok, Benedict Ndubueze Azuogu, Ngozi Ekeke
BACKGROUND: In resource-poor settings with low doctor-population ratio, there is need for equitable distribution of healthcare workforce. The specialty preferences of medical students determine the future composition of physician workforce hence its relevance in career guidance, healthcare planning and policy formulation. This study was aimed at determining the specialty preferences of final year medical students in medical schools of southeast Nigeria, the gender differences in choice of specialty and the availability of career guidance to the students during the period of training...
October 4, 2016: BMC Medical Education
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