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https://www.readbyqxmd.com/read/27918970/-not-just-right-experiences-and-incompleteness-in-body-dysmorphic-disorder
#1
Berta J Summers, Natalie L Matheny, Jesse R Cougle
The current studies examined the role of 'not just right' experiences (NJREs) and incompleteness (INC) in body dysmorphic disorder (BDD). In Study 1, a clinical BDD sample endorsed more severe NJREs than healthy controls, when controlling co-occurring symptoms of depression and anxiety. In Study 2, INC predicted reactivity to an in vivo task designed to evoke BDD-related concerns in an unselected sample. Study 3 demonstrated a positive relationship between INC and BDD symptom severity in a community sample...
November 28, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27918913/reduced-cortical-thickness-in-body-dysmorphic-disorder
#2
Sally A Grace, Ben G Buchanan, Jerome J Maller, Wei Lin Toh, David J Castle, Susan L Rossell
Recent neuroimaging studies in body dysmorphic disorder (BDD) have implicated abnormal structure and function of occipito-temporal and fronto-limbic regions in the potential pathophysiology of the disorder. To date, morphometric investigations have yielded inconsistent results, and have suggested that clinical symptoms may mediate structural brain abnormalities in BDD. We measured Grey Matter (GM) cortical thickness in 20 participants with BDD and 20 healthy control participants matched on age, gender, estimated IQ and handedness...
November 22, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27914726/removal-of-2-mib-and-geosmin-by-electrogenerated-persulfate-performance-mechanism-and-pathways
#3
Lingjun Bu, Shiqing Zhou, Zhou Shi, Lin Deng, Naiyun Gao
In this study, the degradation of 2-methylisoborneol (2-MIB) and geosmin (GSM) was evaluated by electrochemical oxidation (EO) using boron-doped diamond (BDD) electrode. Both 2-MIB and GSM could be degraded efficiently in sulfate electrolyte compared to inert nitrate or perchlorate electrolytes, implying that in-situ generated persulfate may be responsible for contaminants degradation. The observed linear relationship between 2-MIB (GSM) degradation rates and persulfate generation rates further proved that the in-situ generated persulfate enhanced 2-MIB (GSM) degradation...
November 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/27899165/cognitive-dysfunction-in-body-dysmorphic-disorder-new-implications-for-nosological-systems-and-neurobiological-models
#4
Kiri Jefferies-Sewell, Samuel R Chamberlain, Naomi A Fineberg, Keith R Laws
: Introduction Body dysmorphic disorder (BDD) is a debilitating disorder, characterized by obsessions and compulsions relating specifically to perceived appearance, and which has been newly classified within the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Obsessive-Compulsive and Related Disorders grouping. Until now, little research has been conducted into the cognitive profile of this disorder. METHODS: Participants with BDD (n=12) and participants without BDD (n=16) were tested using a computerized neurocognitive battery investigating attentional set-shifting (Intra/Extra Dimensional Set Shift Task), decision-making (Cambridge Gamble Task), motor response-inhibition (Stop-Signal Reaction Time Task), and affective processing (Affective Go-No Go Task)...
November 30, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27869127/main-effects-of-diagnoses-brain-regions-and-their-interaction-effects-for-cerebral-metabolites-in-bipolar-and-unipolar-depressive-disorders
#5
Hai-Zhu Tan, Hui Li, Chen-Feng Liu, Ji-Tian Guan, Xiao-Bo Guo, Can-Hong Wen, Shao-Min Ou, Yin-Nan Zhang, Jie Zhang, Chong-Tao Xu, Zhi-Wei Shen, Ren-Hua Wu, Xue-Qin Wang
Previous studies suggested patients with bipolar depressive disorder (BDd) or unipolar depressive disorder (UDd) have cerebral metabolites abnormalities. These abnormalities may stem from multiple sub-regions of gray matter in brain regions. Thirteen BDd patients, 20 UDd patients and 20 healthy controls (HC) were enrolled to investigate these abnormalities. Absolute concentrations of 5 cerebral metabolites (glutamate-glutamine (Glx), N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), creatine (Cr), parietal cortex (PC)) were measured from 4 subregions (the medial frontal cortex (mPFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and parietal cortex (PC)) of gray matter...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27847122/electrochemical-mineralization-of-cephalexin-using-a-conductive-diamond-anode-a-mechanistic-and-toxicity-investigation
#6
Douglas A C Coledam, Marília M S Pupo, Bianca F Silva, Adilson J Silva, Katlin I B Eguiluz, Giancarlo R Salazar-Banda, José M Aquino
The contamination of surface and ground water by antibiotics is of significant importance due to their potential chronic toxic effects to the aquatic and human lives. Thus, in this work, the electrochemical oxidation of cephalexin (CEX) was carried out in a one compartment filter-press flow cell using a boron-doped diamond (BDD) electrode as anode. During the electrolysis, the investigated variables were: supporting electrolyte (Na2SO4, NaCl, NaNO3, and Na2CO3) at constant ionic strength (0.1 M), pH (3, 7, 10, and without control), and current density (5, 10 and 20 mA cm(-2))...
November 12, 2016: Chemosphere
https://www.readbyqxmd.com/read/27803720/prevalence-of-body-dysmorphic-disorder-and-its-association-with-body-features-in-female-medical-students
#7
Shaik Shaffi Ahamed, Jawaher Enani, Lama Alfaraidi, Lujain Sannari, Rihaf Algain, Zainah Alsawah, Ali Al Hazmi
BACKGROUND: Body dysmorphic disorder (BDD) is a distressing psychiatric disorder. So far there have not been any studies on BDD in Saudi Arabia. OBJECTIVES: The aim of this study was to determine the prevalence of body dysmorphic disorder in female medical students and to investigate whether there is an association between BDD and body features of concern, social anxiety and symptoms of BDD. MATERIALS AND METHODS: A cross sectional study was carried out on female medical students of the college of medicine, King Saud University, Riyadh, Saudi Arabia during January to April, 2015...
June 2016: Iranian Journal of Psychiatry and Behavioral Sciences
https://www.readbyqxmd.com/read/27761610/avoiding-psychological-pitfalls-in-aesthetic-medical-procedures
#8
Qiuyu Wang, Chuan Cao, Rui Guo, Xiaoge Li, Lele Lu, Wenping Wang, Shirong Li
OBJECTIVE: To assess the prevalence of body dysmorphic disorder (BDD) in an aesthetic surgery setting in the region of Southwest China, and to ascertain the differences in terms of body images between patients in the aesthetic setting and general Chinese population. This study tracked patient satisfaction with their body image changes while undergoing aesthetic medical procedures to identify whether the condition of patients who were presenting with BDD symptoms or their psychological symptoms could be improved by enhancing their appearance...
December 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/27761090/screening-for-body-dysmorphic-disorder-in-a-dermatology-outpatient-setting-at-a-tertiary-care-centre
#9
Fibin Thanveer, Niti Khunger
CONTEXT: A distressing pre-occupation with an imagined or slight defect in appearance with a marked negative effect on the patient's life is the core symptom of body dysmorphic disorder (BDD). AIM: To screen the patients attending a dermatology clinic at a tertiary care centre for BDD using the BDD-dermatology version (DV) questionnaire. SETTINGS AND DESIGN: This cross-sectional study enrolled 245 consecutive patients from the dermatology outpatients clinic...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27760403/body-dysmorphic-disorder-symptoms-and-risk-for-suicide-the-role-of-depression
#10
A M Shaw, K A Arditte Hall, E Rosenfield, K R Timpano
Body dysmorphic disorder (BDD) is associated with elevated suicidality. Little is known about why BDD patients are at increased risk. The interpersonal-psychological theory of suicide (IPTS) could clarify suicidality in BDD, and theorizes that perceived burdensomeness and thwarted belongingness lead to suicidal desire, while an acquired capability for suicide is necessary to attempt suicide. No study has investigated how BDD symptoms relate to IPTS constructs or mediators of the relationship between BDD and suicidality...
December 2016: Body Image
https://www.readbyqxmd.com/read/27752342/compliance-of-community-teams-with-specialist-service-recommendations-for-obsessive-compulsive-and-body-dysmorphic-disorders
#11
Paul M Harris, Lynne M Drummond
Aims and method To examine how often referring community mental health teams (CMHTs) utilised treatment recommendations made by the national highly specialised service for patients with severe obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD). We analysed all patient notes for admissions to the unit (August 2012-August 2014) and recorded how many treatment recommendations were implemented by CMHTs prior to admission and at 6 months post-discharge. Results Overall, 66% of our recommendations were met by CMHTs prior to admission and 74% after discharge...
October 2016: BJPsych Bulletin
https://www.readbyqxmd.com/read/27749002/novel-factor-viii-variants-with-a-modified-furin-cleavage-site-improve-the-efficacy-of-gene-therapy-for-hemophilia-a
#12
G N Nguyen, L A George, J I Siner, R J Davidson, C B Zander, X L Zheng, V R Arruda, R M Camire, D E Sabatino
BACKGROUND: The major challenge for developing gene-based therapies for hemophilia A is that human factor VIII (hFVIII) has intrinsic properties that result in inefficient biosynthesis. During intracellular processing, hFVIII is predominantly cleaved at a Paired basic Amino acid Cleaving Enzyme (PACE) or furin cleavage site to yield a heterodimer that is the major form of secreted protein. Previous studies with B-domain deleted (BDD) canine FVIII and hFVIII-R1645H, both differing from hFVIII by a single amino acid at this site, suggested that these proteins are secreted mainly in a single polypeptide chain (SC) form and exhibit enhanced function...
October 17, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27748702/cd4-count-in-hiv-brain-dead-donors-insight-into-donor-risk-assessment-for-hiv-donors
#13
Oscar K Serrano, Scott Kerwin, William D Payne, Timothy L Pruett
BACKGROUND: The HIV Organ Policy Equity (HOPE) Act allows for transplantation of organs from Human Immunodeficiency virus (HIV) infected individuals (HIV+), provided it is performed under a research protocol. The safety assessment of an organ for transplantation is an essential element of the donation process. The risk for HIV associated opportunistic infections increases as circulating CD4+ lymphocytes decrease to <200 cells/μL; however, the numbers of circulating CD4+ cells in the HIV-negative (HIV-) brain dead donor (BDD) is not known...
September 29, 2016: Transplantation
https://www.readbyqxmd.com/read/27740884/thyroid-and-islet-autoantibodies-predict-autoimmune-thyroid-disease-already-at-type-1-diabetes-diagnosis
#14
Berglind Jonsdottir, Christer Larsson, Annelie Carlsson, Gun Forsander, Sten Anders Ivarsson, Åke Lernmark, Johnny Ludvigsson, Claude Marcus, Ulf Samuelsson, Eva Örtqvist, Helena Elding Larsson
CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics. OBJECTIVE: The aim was to determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA- DQ at diagnosis of Type 1 diabetes for autoimmune thyroid disease during subsequent follow-up. SETTING: 43 Paediatric Endocrinology units Sweden. Design, patients and main outcome measures: At diagnosis of Type 1 diabetes, samples from 2433 children were analysed for autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), and the three variants of the zinc transporter 8 (ZnT8W/R/QA) as well as HLA-DQA1-B1 genotypes and thyroid function...
October 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27738644/potential-for-cellular-stress-response-to-hepatic-factor-viii-expression-from-aav-vector
#15
Irene Zolotukhin, David M Markusic, Brett Palaschak, Brad E Hoffman, Meera A Srikanthan, Roland W Herzog
Hemophilia A and B are coagulation disorders resulting from the loss of functional coagulation factor VIII (FVIII) or factor IX proteins, respectively. Gene therapy for hemophilia with adeno-associated virus vectors has shown efficacy in hemophilia B patients. Although hemophilia A patients are more prevalent, the development of therapeutic adeno-associated virus vectors has been impeded by the size of the F8 cDNA and impaired secretion of FVIII protein. Further, it has been reported that over-expression of the FVIII protein induces endoplasmic reticulum stress and activates the unfolded protein response pathway both in vitro and in hepatocytes in vivo, presumably due to retention of misfolded FVIII protein within the endoplasmic reticulum...
2016: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/27734034/circumventing-furin-enhances-factor-viii-biological-activity-and-ameliorates-bleeding-phenotypes-in-hemophilia-models
#16
Joshua I Siner, Benjamin J Samelson-Jones, Julie M Crudele, Robert A French, Benjamin J Lee, Shanzhen Zhou, Elizabeth Merricks, Robin Raymer, Timothy C Nichols, Rodney M Camire, Valder R Arruda
Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645-1648) in the design of B-domain-deleted FVIII (FVIII-BDD) products in current clinical use and in the drug development pipeline, as well as in experimental FVIII gene therapy strategies. Here, we report that processing by furin is in fact deleterious to FVIII-BDD secretion and procoagulant activity...
October 6, 2016: JCI Insight
https://www.readbyqxmd.com/read/27733297/landfill-leachate-treatment-by-sequential-membrane-bioreactor-and-electro-oxidation-processes
#17
Mehdi Zolfaghari, Karama Jardak, Patrick Drogui, Satinder Kaur Brar, Gerardo Buelna, Rino Dubé
Combination of high performance membrane bioreactor (MBR) equipped with ultrafiltration and electro-oxidation process (EOP) by boron-doped diamond electrode (BDD) was used to effectively treat highly contaminated old landfill leachate. MBR and EOP were optimized for raw and pretreated landfill leachate. Seasonal changes dramatically affected the both processes' performance, as the landfill leachate was ¾ more concentrated in winter. For MBR, organic load rate of 1.2 gCOD/L/day and sludge retention time of 80 days was considered as the optimum operating condition in which COD, TOC, NH4(+) and phosphorous removal efficiencies reached the average of 63, 35, 98 and 52%, respectively...
October 9, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27728881/removal-of-artificial-sweetener-aspartame-from-aqueous-media-by-electrochemical-advanced-oxidation-processes
#18
Heng Lin, Nihal Oturan, Jie Wu, Virender K Sharma, Hui Zhang, Mehmet A Oturan
The degradation and mineralization of aspartame (ASP) in aqueous solution were investigated, for the first time, by electrochemical advanced oxidation processes (EAOPs) in which hydroxyl radicals were formed concomitantly in the bulk from Fenton reaction via in situ electrogenerated Fenton's reagent and at the anode surface from the water oxidation. Experiments were performed in an undivided cylindrical glass cell with a carbon-felt cathode and a Pt or boron-doped diamond (BDD) anode. The effect of Fe(2+) concentration and applied current on the degradation and mineralization kinetics of ASP was evaluated...
October 8, 2016: Chemosphere
https://www.readbyqxmd.com/read/27716467/sub-stoichiometric-titanium-oxide-ti4o7-as-a-suitable-ceramic-anode-for-electrooxidation-of-organic-pollutants-a-case-study-of-kinetics-mineralization-and-toxicity-assessment-of-amoxicillin
#19
Soliu O Ganiyu, Nihal Oturan, Stéphane Raffy, Marc Cretin, Roseline Esmilaire, Eric van Hullebusch, Giovanni Esposito, Mehmet A Oturan
Electrochemical degradation of aqueous solutions containing antibiotic amoxicillin (AMX) has been extensively studied in an undivided electrolytic cell using a sub-stoichiometric titanium oxide (Ti4O7) anode, elaborated by plasma deposition. Oxidative degradation of AMX by hydroxyl radicals was assessed as a function of applied current and was found to follow pseudo-first order kinetics. The use of carbon-felt cathode enhanced oxidation capacity of the process due to the generation of H2O2. Comparative studies at low current intensity using dimensional stable anode (DSA) and Pt anodes led to the lower mineralization efficiencies compared to Ti4O7 anode: 36 and 41% TOC removal for DSA and Pt respectively compared to 69% for Ti4O7 anode...
September 28, 2016: Water Research
https://www.readbyqxmd.com/read/27704079/evaluation-of-a-nitrogen-incorporated-tetrahedral-amorphous-carbon-thin-film-for-the-detection-of-tryptophan-and-tyrosine-using-flow-injection-analysis-with-amperometric-detection
#20
Romana Jarošová, Joy Rutherford, Greg M Swain
We report on the analytical performance of a tetrahedral amorphous carbon (ta-C:N) thin-film electrode in flow injection analysis with amperometric detection. Two model redox analytes were used to evaluate the electrode response because of their positive detection potentials and propensity (i.e., reaction products) to adsorb and foul sp(2) carbon electrodes: tyrosine and tryptophan. ta-C:N electrodes are attractive for electroanalytical applications because they possesses many of the excellent properties of boron-doped nanocrystalline diamond (BDD) and they can be deposited at or near room temperature...
October 17, 2016: Analyst
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