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https://www.readbyqxmd.com/read/29913440/validation-of-a-new-low-cost-methanol-based-fixative-for-cervical-cytology-and-human-papillomavirus-detection
#1
Katia Ramos Moreira Leite, Thais Silva, Bruna Naum, Flavio Canavez, Juliana Canavez, Ruan Pimenta, Sabrina Reis, Luiz Heraldo Camara-Lopes
OBJECTIVE: To test the performance of a new fixative for pap smear collection for liquid-based cervical cytology, CellPreserv® and compare it with the commercially available, PreservCyt® used in the diagnosis and detection of human papillomavirus (HPV). METHODS: Seven hundred twenty five women participated in this study after signing an informed consent. The specimens were collected using a traditional device, agitated in PBS, and equally divided in both fixatives...
June 18, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29913375/versatile-graphene-biosensors-for-enhancing-human-cell-therapy
#2
REVIEW
George M Vlăsceanu, Roxana-Maria Amărandi, Mariana Ioniță, Teddy Tite, Horia Iovu, Luisa Pilan, Jorge S Burns
Technological advances in engineering and cell biology stimulate novel approaches for medical treatment, in particular cell-based therapy. The first cell-based gene therapy against cancer was recently approved by the US Food and Drug Administration. Progress in cancer diagnosis includes a blood test detecting five cancer types. Numerous stem cell phase I/II clinical trials showing safety and efficacy will soon pursue qualifying criteria for advanced therapy medicinal products (ATMP), aspiring to join the first stem-cell therapy approved by the European Medicines Agency...
May 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29913305/an-investigation-of-the-viscoelastic-properties-and-the-actin-cytoskeletal-structure-of-triple-negative-breast-cancer-cells
#3
Jingjie Hu, Yuxiao Zhou, John D Obayemi, Jing Du, Winston O Soboyejo
An improved understanding of the evolution of cell structure and viscoelasticity with cancer malignancy could enable the development of a new generation of biomarkers and methods for cancer diagnosis. Hence, in this study, we present the viscoelastic properties (moduli and viscosities) and the actin cytoskeletal structures of triple negative breast cancer (TNBC) cells with different metastatic potential. These include: MCF-10A normal breast cells (studied as a control); MDA-MB-468 cells (less metastatic TNBC cells), and MDA-MB-231 cells (highly metastatic TNBC cells)...
May 30, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29913239/plasma-mirnas-in-diagnosis-and-prognosis-of-pancreatic-cancer-a-mirna-expression-analysis
#4
Xin Zhou, Zipeng Lu, Tongshan Wang, Zebo Huang, Wei Zhu, Yi Miao
The differential expression of microRNAs (miRNAs) in plasma of pancreatic cancer (PC) patients may act as a diagnostic biomarker. A four-stage study was performed to identify plasma miRNAs with potential in detecting PC. Exiqon panels (20 PC vs. 10 normal controls (NCs)) were applied in the screening phase to obtain miRNA profiling. The identified miRNAs were further assessed in the training (40 PC vs. 40 NCs) and testing stages (112 PC vs. 116 NCs) with qRT-PCR assays. A six-miRNA signature including up-regulated miR-122-5p, miR-125b-5p, miR-192-5p, miR-193b-3p, miR-221-3p and miR-27b-3p was identified...
June 15, 2018: Gene
https://www.readbyqxmd.com/read/29913059/quality-of-life-of-head-and-neck-cancer-patients-in-urban-and-regional-areas-an-australian-perspective
#5
Kelsey A Pateman, Nicole L Cockburn, Martin D Batstone, Pauline J Ford
OBJECTIVE: Head and neck cancer treatment affects quality of life. There are differences in quality of life outcomes and perceived supportive care needs between cancer patients living in metropolitan and regional-remote areas. This study investigated quality of life over the first 6 months following head and neck cancer diagnosis and observed differences in quality of life by geographical location. DESIGN: Prospective observational study. SETTING: Tertiary hospital in Brisbane, Australia...
June 2018: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29912760/the-role-of-insulin-like-growth-factor-igf-axis-in-early-diagnosis-of-pancreatic-adenocarcinoma-pdac
#6
Barbara Wlodarczyk, Anita Gasiorowska, Ewa Malecka-Panas
New-onset diabetes mellitus (DM) is one of the first symptoms of pancreatic adenocarcinoma (PDAC). The frequency of endocrine disorders is estimated between 40% and 80% in patients with pancreatic cancer. DM is a risk factor for cancer development but it may also be a consequence of the tumor growth. Data confirming the existence of a relationship between long standing type 2 DM and an increased risk of PDAC comes from numerous clinical studies. Insulin resistance phenomenon and hyperinsulinemia may result in the increased proliferation of pancreatic islets which in turn may cause a predisposition to cancer development...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912667/exploration-of-dna-methylation-markers-for-diagnosis-and-prognosis-of-patients-with-endometrial-cancer
#7
Jianchao Ying, Teng Xu, Qian Wang, Jun Ye, Jianxin Lyu
The accurate diagnosis of endometrial cancer (EC) holds great promise for improving its treatment choice and prognosis prediction. This work aimed to identify diagnostic biomarkers for differentiating EC tumors from tumors in other tissues, as well as prognostic signatures for predicting survival in EC patients. We identified 48 tissue-specific markers using a cohort of genome-wide methylation data from three common gynecological tumors and their corresponding normal tissues. A diagnostic classifier was constructed based on these 48 CpG markers that could predict cancerous versus normal tissue with an overall correct rate of 98...
June 18, 2018: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29912592/breast-cancer-during-pregnancy-results-of-maternal-and-perinatal-outcomes-in-a-single-institution-and-systematic-review-of-the-literature
#8
Natalia R Gomez-Hidalgo, Elsa Mendizabal, Laura Joigneau, Pilar Pintado, Juan De Leon-Luis
To compare the maternal and the perinatal variables of the patients with pregnancy associated breast cancer (PABC) and the pregnant patients without breast cancer (PNABC), we retrospectively included 13 PABC cases and 66.265 PNABC patients. The PABC patients presented a lower mean gestational age at their delivery and had higher induction of labour and prematurity rates. A diagnosis was performed before stage III in 77% of the cases. The overall survival was 90%; moreover, we collected 16 manuscripts when gathering data from 1581 patients with PABC...
June 18, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29912434/evidence-based-optimization-of-post-treatment-surveillance-for-skull-base-chordomas-based-on-local-and-distant-disease-progression
#9
Jacob L Freeman, Ascher B Kaufmann, Richard G Everson, Franco DeMonte, Shaan M Raza
BACKGROUND: There are no guidelines regarding post-treatment surveillance specific to skull base chordomas. OBJECTIVE: To determine an optimal imaging surveillance schedule to detect both local and distant metastatic skull base chordoma recurrences. METHODS: A retrospective review of 91 patients who underwent treatment for skull base chordoma between 1993 and 2017 was conducted. Time to and location of local and distant recurrence(s) were cataloged...
April 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29912335/cessation-of-cigarette-smoking-and-the-impact-on-cancer-incidence-in-hiv-positive-persons-the-d-a-d-study
#10
Leah Shepherd, Lene Ryom, Matthew Law, Kathy Petoumenos, Camilla Ingrid Hatleberg, Antonella d'Arminio Monforte, Caroline Sabin, Mark Bower, Fabrice Bonnet, Peter Reiss, Stephane de Wit, Christian Pradier, Rainer Weber, Wafaa El-Sadr, Jens Lundgren, Amanda Mocroft
Background: Cancers are a major source of morbidity and mortality for HIV-positive persons on combination antiretroviral therapy, while the clinical benefits of smoking cessation are not well established. Methods: Participants were followed from 1 January 2004 until first cancer diagnosis, death, or 1 February 2016. Smoking status was defined as ex (<1,1-2,2-3,3-5,>5 years since stopping), current, and never smokers. Outcomes considered were any cancer, lung cancer, other smoking-related excluding lung and smoking-unrelated cancers...
June 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29912328/the-impact-of-cancer-on-subsequent-chance-of-pregnancy-a-population-based-analysis
#11
Richard A Anderson, David H Brewster, Rachael Wood, Sian Nowell, Colin Fischbacher, Tom W Kelsey, W Hamish B Wallace
STUDY QUESTION: What is the impact of cancer in females aged ≤39 years on subsequent chance of pregnancy? SUMMARY ANSWER: Cancer survivors achieved fewer pregnancies across all cancer types, and the chance of achieving a first pregnancy was also lower. WHAT IS KNOWN ALREADY: The diagnosis and treatment of cancer in young females may be associated with reduced fertility but the true pregnancy deficit in a population is unknown. STUDY DESIGN, SIZE, DURATION: We performed a retrospective cohort study relating first incident cancer diagnosed between 1981 and 2012 to subsequent pregnancy in all female patients in Scotland aged 39 years or less at cancer diagnosis (n = 23 201)...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912223/-ten-questions-about-pericardial-effusion
#12
Massimo Imazio, George Lazaros, Antonio Brucato
Although a new or worsening pericardial effusion is a diagnostic criterion for pericarditis, in clinical practice the presence of pericardial effusion does not necessarily imply the evidence of pericarditis. Up to 40-50% of cases of pericarditis do not show the presence of pericardial effusion (dry pericarditis). The clinician should first evaluate any related symptoms and signs (symptomatic vs asymptomatic), its size and hemodynamic impact, then rule out pericarditis and the presence of an underlying disease (e...
June 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29912175/design-and-parameter-study-of-integrated-microfluidic-platform-for-ctc-isolation-and-enquiry-a-numerical-approach
#13
Amir Shamloo, Saba Ahmad, Maede Momeni
Being the second cause of mortality across the globe, there is now a persistent effort to establish new cancer medication and therapies. Any accomplishment in treating cancers entails the existence of accurate identification systems empowering the early diagnosis. Recent studies indicate CTCs&rsquo; potential in cancer prognosis as well as therapy monitoring. The chief shortcoming with CTCs is that they are exceedingly rare cells in their clinically relevant concentration. Here, we simulated a microfluidic construct devised for immunomagnetic separation of the particles of interest from the background cells...
June 18, 2018: Biosensors
https://www.readbyqxmd.com/read/29911967/from-principles-to-practice-real-world-patient-and-stakeholder-engagement-in-breast-cancer-research
#14
Sarah M Greene, Susan Brandzel, Karen J Wernli
The Patient-Centered Outcomes Research Institute (PCORI) in Washington, DC, has catalyzed a meaningful shift in the composition of research project teams since its initial research funding cycle in 2011. Despite the influx of funding in the research community for patient-centered research, research on how to effectively engage patients and stakeholders in the research process is still relatively nascent. Kaiser Permanente Washington Health Research Institute (KPWHRI) in Seattle, WA, was an early recipient of PCORI research funding and, as of December 2017, has received 8 PCORI research awards totaling nearly $15 million...
June 6, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29911510/mixed-adenoneuroendocrine-carcinoma-of-the-colon-and-rectum
#15
S Qiu, G Pellino, O J Warren, S Mills, R Goldin, C Kontovounisios, P P Tekkis
Mixed adenoneuroendocrine carcinoma (MANEC) are rare cancers of the gastrointestinal (GI) and pancreatobiliary tract. They are characterized by the presence of a combination of epithelial and neuroendocrine elements, where each component represents at least 30% of the tumour. Review of literature and consolidation of clinicopathological data. Sixty-one cases of colorectal MANEC have been reported in literature and one seen in this centre. The median age of the patients affected was 61.9 ± 12.4 years (20-94 years)...
June 17, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29911502/nodular-melanoma-presenting-as-an-exophytic-subungual-mass
#16
B Finlay, T Ramachandren, K Hussey, S Parkyn, K Meyer, K Barrett
Despite being recognised and reported in the literature for decades, subungual melanoma of the foot remains a diagnostic pitfall, with it commonly being mistaken for benign conditions. We present an interesting case of delayed diagnosis of subungual melanoma of the hallux that was misdiagnosed in the community for over one year. With melanoma being the fourth most commonly diagnosed cancer in Australia in 2013, this case serves as a reminder to all clinicians about the importance of maintaining a high index of suspicion for melanoma of the foot...
January 1, 2018: Scottish Medical Journal
https://www.readbyqxmd.com/read/29911263/novel-competitive-chemiluminescence-dna-assay-based-on-fe-3-o-4-sio-2-au-functionalized-magnetic-nanoparticles-for-sensitive-detection-of-p53-tumor-suppressor-gene
#17
Linyu Wang, Manwen Yao, Xiangyi Fang, Xi Yao
A simple, rapid response time and ultrahigh sensitive chemiluminescence (CL) DNA assay based on Fe3 O4 @SiO2 @Au-functionalized magnetic nanoparticles (Au-MNPs) was developed for detection of p53 tumor suppressor gene. In this study, 2',6'-dimethylcarbonylphenyl-10-sulfopropyl acridinium-9-carboxylate 4'-NHS ester (NSP-DMAE-NHS), as a new kind of highly efficient luminescence reagent, was immobilized on the complementary sequence of the wild-type p53 (ssDNA) to improve the detection sensitivity. The optimal concentration of ssDNA-(NSP-DMAE-NHS) conjugates mixed with the wild-type p53 (wtp53) samples respectively...
June 18, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29911113/survival-outcomes-for-advanced-kidney-cancer-patients-in-the-era-of-targeted-therapies
#18
Arpit Rao, Charles Wiggins, Richard C Lauer
Background: Advanced renal cell carcinoma (RCC) results in over 14,000 deaths each year in the United States alone. The therapeutic landscape for advanced RCC changed dramatically with the approval of tyrosine kinase inhibitors (TKI) between 2006 and 2012. A large-scale analysis of survival trends has not been performed in the TKI era to determine their impact on outcomes for advanced RCC patients. Methods: The Surveillance, Epidemiology and End-Results (SEER) database was queried for adult patients with advanced RCC diagnosed between 2000 and 2013...
May 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29911111/understanding-patterns-of-brain-metastasis-in-breast-cancer-and-designing-rational-therapeutic-strategies
#19
REVIEW
Evelyn M Brosnan, Carey K Anders
One of the most feared sequelae after a diagnosis of advanced breast cancer is development of metastases to the brain as this diagnosis can affect physical function, independence, relationships, quality of life, personality, and ultimately one's sense of self. The propensity to develop breast cancer brain metastases (BCBMs) varies by subtype, occurring in up to one half of those with triple negative breast cancer (TNBC), approximately a third of HER+ breast cancers and 14% in hormone positive disease. Median survival after BCBM diagnosis can be as short as 5 months in TNBC and 10-18 months in the other subtypes...
May 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29910995/automatic-lung-segmentation-with-juxta-pleural-nodule-identification-using-active-contour-model-and-bayesian-approach
#20
Heewon Chung, Hoon Ko, Se Jeong Jeon, Kwon-Ha Yoon, Jinseok Lee
OBJECTIVE: chest computed tomography (CT) images and their quantitative analyses have become increasingly important for a variety of purposes, including lung parenchyma density analysis, airway analysis, diaphragm mechanics analysis, and nodule detection for cancer screening. Lung segmentation is an important prerequisite step for automatic image analysis. We propose a novel lung segmentation method to minimize the juxta-pleural nodule issue, a notorious challenge in the applications...
2018: IEEE Journal of Translational Engineering in Health and Medicine
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