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https://www.readbyqxmd.com/read/28550787/apocrine-sweat-gland-adenocarcinoma-a-rare-case-report-and-review
#1
Arthur Paredes Gatti, Luiza Tonello, William Pfaffenzeller, Fernando Oliveira Savóia, Diego Inácio Goergen, Rodrigo De Pieri Coan, Uirá Fernandes Teixeira, Fábio Luiz Waechter, Paulo Roberto Ott Fontes
INTRODUCTION: Primary apocrine sweat gland carcinoma (PASGC) is an extremely rare neoplasia whose management and treatment are still evolving. The only curative therapy is wide local excision. Many patients have metastasis at the time of the diagnosis, mainly because this neoplasm has been misdiagnosed as some benign skin lesions. PRESENTATION OF CASE: We herein report a case of a 72-year-old-man with PASGC affecting the axilla and regional lymph nodes that underwent surgical resection and lymphadenectomy at our Institution...
May 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28550712/combined-immune-checkpoint-blockade-anti-pd-1-anti-ctla-4-evaluation-and-management-of-adverse-drug-reactions
#2
REVIEW
Jessica C Hassel, Lucie Heinzerling, Jens Aberle, Oliver Bähr, Thomas K Eigentler, Marc-Oliver Grimm, Victor Grünwald, Jan Leipe, Niels Reinmuth, Julia K Tietze, Jörg Trojan, Lisa Zimmer, Ralf Gutzmer
Combined immune checkpoint blockade (ICB) provides unprecedented efficacy gains in numerous cancer indications, with PD-1 inhibitor nivolumab plus CTLA-4 inhibitor ipilimumab in advanced melanoma as first-ever approved therapies for combined ICB. However, gains in efficacy must be balanced against a higher frequency and severity of adverse drug reactions (ADR). Because delays in diagnosis and management might result in symptom worsening and further complications, clinicians shall be well trained to identify ADR promptly and monitor patients adequately...
May 18, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28550673/-clinical-characteristics-diagnosis-and-treatment-of-pulmonary-inflammatory-myofibroblastic-tumor-in-children
#3
F H Wang, J H Liang, J H Zeng, J Tang, H Wang, W Liu
Objective: To explore the clinical characteristics, diagnosis and treatment of pulmonary inflammatory myofibroblastic tumor in children. Methods: The clinical data of 13 patients with pulmonary inflammatory myofibroblastic tumor between October 2009 and October 2015 were retrospectively analyzed, including 9 boys and 4 girls aged 1 to 12 years 4 months (mean 4 years 9 months). Seven patients underwent total tumor resection, 4 had lobectomy, 1 had partial tumor resection and 1 had biopsy. The follow-up time ranged from 2 months to 6 years and 2 months...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28550661/-progression-of-diagnosis-and-treatment-for-adenosquamous-lung-carcinoma
#4
W J Zhao, X Wang, K W Ma
Adenosquamous lung carcinoma (ASC) is an uncommon entity of the primary lung cancer, which is mixed by adenocarcinoma and squamous carcinoma cells. ASC not only possesses the malignant biological characteristics of adenocarcinoma and squamous cell carcinoma, but also exhibits special clinical features, such as the higher malignant degree and poorer prognosis. This paper is aimed to elaborate the research process of the pathological origin of ASC, the application of different diagnostic methods in ASC, various therapeutic strategies and its associated prognosis so as to help to develop the clinical strategies of ASC...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28550623/malignant-tumors-associated-with-juvenile-polyposis-syndrome-in-japan
#5
REVIEW
Hideyuki Ishida, Keiichiro Ishibashi, Takeo Iwama
PURPOSE: The risk of malignant tumors developing in association with juvenile polyposis syndrome (JPS) was evaluated to explore the optimal treatment for this rare disease. METHODS: We reviewed the data on JPS cases reported in Japan between January, 1971 and March, 2016. RESULTS: A total of 171 cases were evaluable. Of these 171 patients, 83 (48.5%) were female and the median age at diagnosis was 28 years (range 1-80 years). The polyps were located in the stomach alone (n = 62; 36...
May 26, 2017: Surgery Today
https://www.readbyqxmd.com/read/28550611/-18-f-fluorodeoxyglucose-positron-emission-tomography-in-the-diagnosis-of-malignancy-in-patients-with-paraneoplastic-neurological-syndrome-a-systematic-review-and-meta-analysis
#6
REVIEW
Ana María García Vicente, Roberto C Delgado-Bolton, Mariano Amo-Salas, Jesús López-Fidalgo, Ana Paula Caresia Aróztegui, José Ramón García Garzón, Javier Orcajo Rincón, María José García Velloso, María de Arcocha Torres, Soledad Alvárez Ruíz
PURPOSE: The detection of occult cancer in patients suspected of having a paraneoplastic neurological syndrome (PNS) poses a diagnostic challenge. The aim of our study was to perform a systematic review and meta-analysis to assess the diagnostic performance of FDG PET for the detection of occult malignant disease responsible for PNS. METHODS: A systematic review of the literature (MEDLINE, EMBASE, Cochrane, and DARE) was undertaken to identify studies published in any language...
May 27, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28550488/the-value-of-preoperative-positron-emission-tomography-computed-tomography-in-node-negative-endometrial-cancer-on-magnetic-resonance-imaging
#7
Jeong-Yeol Park, Jong Jin Lee, Hyuck Jae Choi, In Hye Song, Chang Ohk Sung, Hye Ok Kim, Sun-Young Chae, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVE: The aim of this study was to investigate the value of [18F]fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in predicting lymph node status in node-negative endometrial cancer on preoperative magnetic resonance imaging (MRI). METHODS: Patients with endometrial cancer who underwent both preoperative MRI and FDG-PET/CT followed by hysterectomy and lymphadenectomy were initially included. We then enrolled patients with MRI-defined node-negative disease (lymph nodes <1 cm in the short-axis diameter, or no visible lymph node)...
May 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28550274/herpes-zoster-in-breast-cancer-a-case-report
#8
Darvishi Mohammad, Vasei Narges
There is little information on herpes zoster infection in breast cancer patients as a complication during adjuvant chemotherapy. We report a case of herpes zoster in a 65-year-old woman presented with low grade fever and vital signs together with skin symptoms such as severe edema, irritation and itching in the left breast where there was wound drainage. PCR test revealed varicella zoster virus. To the best of our knowledge, the histologic features coupled with PCR led to a diagnosis of herpes zoster.
May 26, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28550083/normal-and-cancerous-tissues-release-extrachromosomal-circular-dna-eccdna-into-the-circulation
#9
Pankaj Kumar, Laura Dillon, Yoshiyuki Shibata, Amir A Jazaeri, David R Jones, Anindya Dutta
Cell-free circulating linear DNA is being explored for non-invasive diagnosis and management of tumors and fetuses, the so-called liquid biopsy. Previously, we observed the presence of small extrachromosomal circular DNA (eccDNA), called microDNA, in the nuclei of mammalian tissues and cell lines. Now, we demonstrate that cell-free microDNA derived from uniquely mapping regions of the genome is detectable in plasma and serum from both mice and humans and that they are significantly longer (30-60% >250 bases) than cell-free circulating linear DNA (~150 bases)...
May 26, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28550032/a-predictive-score-for-thrombosis-associated-with-breast-colorectal-lung-or-ovarian-cancer-the-prospective-compass-cancer-associated-thrombosis-study
#10
Grigoris T Gerotziafas, Ali Taher, Hikmat Abdel-Razeq, Essam AboElnazar, Alex C Spyropoulos, Salem El Shemmari, Annette K Larsen, Ismail Elalamy
BACKGROUND: The stratification of outpatients on chemotherapy for breast, colorectal, lung, and ovarian cancers at risk of venous thromboembolism (VTE) remains an unmet clinical need. The derivation of a risk assessment model (RAM) for VTE in these patients was the aim of the study "Prospective Comparison of Methods for thromboembolic risk assessment with clinical Perceptions and AwareneSS in real life patients-Cancer Associated Thrombosis" (COMPASS-CAT). PATIENTS AND METHODS: The derivation cohort consisted of 1,023 outpatients...
May 26, 2017: Oncologist
https://www.readbyqxmd.com/read/28549976/brca-mutational-status-initial-disease-presentation-and-clinical-outcome-in-high-grade-serous-advanced-ovarian-cancer-a-multicenter-study
#11
Marco Petrillo, Claudia Marchetti, Rossella De Leo, Angela Musella, Ettore Capoluongo, Ida Paris, Pierluigi Benedetti Panici, Giovanni Scambia, Anna Fagotti
BACKGROUND: In the last decades, several efforts have been done to clarify the role of BRCA mutational status in women with advanced ovarian cancer demonstrating its role in cancer development, as well as the prognostic significance of BRCA genotype. OBJCTIVE: Our aim is to evaluate the correlation between BRCA mutational status and disease presentation in a large series of advanced high-grade serous ovarian cancer patients. STUDY DESIGN: this is a retrospective multicenter study including a consecutive series of newly diagnosed high-grade serous ovarian cancer patients with FIGO Stage IIIC-IV disease, at least 18 months of follow-up time, tested for BRCA 1/2 germline mutation status...
May 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28549957/three-stage-esophagectomy-combined-with-abdominal-aortic-aneurysm-repair-first-case-in-the-literature
#12
Chris Klonaris, Dimitrios Schizas, Georgios Karaolanis, Dimitrios Athanasiadis, Andreas Alexandrou, Theodore Liakakos
The purpose of this report is to describe the synchronous surgical treatment of an abdominal aortic aneurysm (AAA) with concomitant esophageal cancer (EC) with a three-stage esophagectomy, a real management challenge especially in establishing the therapeutic priorities and the ideal treatment approach. A 65-year old male was referred for treatment in our hospital with the diagnosis of AAA. He complained of general fatigue, weight loss and intermittent dysphagia. Contrast-enhanced CT and upper endoscopy showed the AAA and a large gastroesophageal junction (GEJ) tumor respectively...
May 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28549862/clinicopathologic-characteristics-and-prognosis-of-xp11-2-translocation-renal-cell-carcinoma-multicenter-propensity-score-matching-analysis
#13
Min Soo Choo, Chang Wook Jeong, Cheryn Song, Hwang Gyun Jeon, Seong Il Seo, Sung Kyu Hong, Seok-Soo Byun, Jin Soo Chung, Sung-Hoo Hong, Eu Chang Hwang, Hyeon Hoe Kim, Cheol Kwak
BACKGROUND: We evaluated the clinicopathologic characteristics and prognosis of Xp11.2 translocation (Xp11.2t) renal cell carcinoma (RCC) from a multicenter study and compare them with clear-cell RCC using a propensity score matching analysis. PATIENTS AND METHODS: Between 2004 and 2013, 8384 consecutive patients from 7 institutions who were diagnosed with RCC were reviewed, and the pathologically confirmed Xp11.2t cases were enrolled. The oncological outcomes of Xp11...
April 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28549831/adenocarcinoma-of-the-appendix-with-extra-appendicular-spread-clinico-surgical-and-histologic-analysis-of-27-cases
#14
Francisco J Morera Ocón, Bruno Camps Vilata, Elena Muñoz Forner, Clara Navarro Campoy, Javier Gallego Plazas, Samuel Navarro Fos
BACKGROUND AND OBJECTIVES: Appendiceal neoplasms with extra-appendiceal spread may show different clinical patterns with pseudomyxoma peritonei (PMP) being one of them. We analyse the results in a series of patients treated in our centre. MATERIAL AND METHODS: Retrospective study of patients operated on for appendiceal peritoneal carcinomatosis from January 2012 to May 2015. RESULTS: Twenty-seven consecutive patients were included. Median age 63 years (26-73); 14 were men...
May 23, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28549791/micrornas-in-gynecological-cancers-small-molecules-with-big-implications
#15
Sanjeev K Srivastava, Aamir Ahmad, Haseeb Zubair, Orlandric Miree, Seema Singh, Rodney P Rocconi, Jennifer Scalici, Ajay P Singh
Gynecological cancers (GCs) are often diagnosed at advanced stages, limiting the efficacy of available therapeutic options. Thus, there remains an urgent and unmet need for innovative research for the efficient clinical management of GC patients. Research over past several years has revealed the enormous promise of miRNAs. These small non-coding RNAs can aid in the diagnosis, prognosis and therapy of all major GCs, viz., ovarian cancers, cervical cancers and endometrial cancers. Mechanistic details of the miRNAs-mediated regulation of multiple biological functions are under constant investigation, and a number of miRNAs are now believed to influence growth, proliferation, invasion, metastasis, chemoresistance and the relapse of different GCs...
May 23, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28549783/irinotecan-temozolomide-with-temsirolimus-or-dinutuximab-in-children-with-refractory-or-relapsed-neuroblastoma-cog-anbl1221-an-open-label-randomised-phase-2-trial
#16
Rajen Mody, Arlene Naranjo, Collin Van Ryn, Alice L Yu, Wendy B London, Barry L Shulkin, Marguerite T Parisi, Sabah-E-Noor Servaes, Mitchell B Diccianni, Paul M Sondel, Julia G Bender, John M Maris, Julie R Park, Rochelle Bagatell
BACKGROUND: Outcomes for children with relapsed and refractory neuroblastoma are dismal. The combination of irinotecan and temozolomide has activity in these patients, and its acceptable toxicity profile makes it an excellent backbone for study of new agents. We aimed to test the addition of temsirolimus or dinutuximab to irinotecan-temozolomide in patients with relapsed or refractory neuroblastoma. METHODS: For this open-label, randomised, phase 2 selection design trial of the Children's Oncology Group (COG; ANBL1221), patients had to have histological verification of neuroblastoma or ganglioneuroblastoma at diagnosis or have tumour cells in bone marrow with increased urinary catecholamine concentrations at diagnosis...
May 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28549474/a-rare-presentation-of-metastatic-prostate-cancer-initially-a-suspect-for-urothelial-cell-carcinoma-of-the-ureter-a-case-report
#17
Ho Seok Chung, Myung Soo Kim, Yang Hyun Cho, Eu Chang Hwang, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Suk Hee Heo, Chan Choi
BACKGROUND: The most common metastatic sites of prostate cancer are the lymph nodes and bone. Ureteral metastasis from prostate cancer is very unusual and only a few cases have been reported. CASE PRESENTATION: We describe a 76-year-old male with ureteral metastasis of prostate cancer along with a review of the literature. Initially, based on the diagnostic evaluation, urothelial cell carcinoma of the left distal ureter was suspected. Nephroureterectomy with bladder cuff excision was performed...
May 26, 2017: BMC Urology
https://www.readbyqxmd.com/read/28549410/large-scale-tissue-histopathology-image-classification-segmentation-and-visualization-via-deep-convolutional-activation-features
#18
Yan Xu, Zhipeng Jia, Liang-Bo Wang, Yuqing Ai, Fang Zhang, Maode Lai, Eric I-Chao Chang
BACKGROUND: Histopathology image analysis is a gold standard for cancer recognition and diagnosis. Automatic analysis of histopathology images can help pathologists diagnose tumor and cancer subtypes, alleviating the workload of pathologists. There are two basic types of tasks in digital histopathology image analysis: image classification and image segmentation. Typical problems with histopathology images that hamper automatic analysis include complex clinical representations, limited quantities of training images in a dataset, and the extremely large size of singular images (usually up to gigapixels)...
May 26, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28549339/typical-and-atypical-presenting-symptoms-of-breast-cancer-and-their-associations-with-diagnostic-intervals-evidence-from-a-national-audit-of-cancer-diagnosis
#19
Minjoung Monica Koo, Christian von Wagner, Gary A Abel, Sean McPhail, Greg P Rubin, Georgios Lyratzopoulos
INTRODUCTION: Most symptomatic women with breast cancer have relatively short diagnostic intervals but a substantial minority experience prolonged journeys to diagnosis. Atypical presentations (with symptoms other than breast lump) may be responsible. METHODS: We examined the presenting symptoms of breast cancer in women using data from a national audit initiative (n=2316). Symptoms were categorised topographically. We investigated variation in the length of the patient interval (time from symptom onset to presentation) and the primary care interval (time from presentation to specialist referral) across symptom groups using descriptive analyses and quantile regression...
May 23, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28549211/chronic-sinonasal-tract-inflammation-as-a-precursor-to-nasopharyngeal-carcinoma-and-sinonasal-malignancy-in-the-united-states
#20
Eric L Wu, Charles A Riley, Mei-Chin Hsieh, Michael J Marino, Xiao-Cheng Wu, Edward D McCoul
BACKGROUND: Chronic inflammatory states have been linked to the development of malignancy. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) have been associated with nasopharyngeal carcinoma (NPC) in population-based studies in Asia. A similar association with NPC and paranasal sinus malignancy (PSM) has not been defined in a North American population. Our purpose was to investigate the impact of CRS and AR on the risk of NPC and PSM. METHODS: The Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database was queried as a case-control study of adults ≥65 years of age...
May 23, 2017: International Forum of Allergy & Rhinology
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