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https://www.readbyqxmd.com/read/29662203/potent-antitumor-efficacy-of-anti-gd2-car-t-cells-in-h3-k27m-diffuse-midline-gliomas
#1
Christopher W Mount, Robbie G Majzner, Shree Sundaresh, Evan P Arnold, Meena Kadapakkam, Samuel Haile, Louai Labanieh, Esther Hulleman, Pamelyn J Woo, Skyler P Rietberg, Hannes Vogel, Michelle Monje, Crystal L Mackall
Diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMGs) with mutated histone H3 K27M (H3-K27M)1-5 are aggressive and universally fatal pediatric brain cancers 6 . Chimeric antigen receptor (CAR)-expressing T cells have mediated impressive clinical activity in B cell malignancies7-10 , and recent results suggest benefit in central nervous system malignancies11-13 . Here, we report that patient-derived H3-K27M-mutant glioma cell cultures exhibit uniform, high expression of the disialoganglioside GD2...
April 16, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29657891/stereotactic-radiosurgery-for-primary-tumors-of-the-spine-and-spinal-cord-%C3%A2
#2
Erinma Elibe, David Boyce-Fappiano, Samuel Ryu, M Salim Siddiqui, Ian Lee, Jack Rock, Farzan Siddiqui
Purpose: The purpose of this study was to evaluate the role of stereotactic radiosurgery in the treatment of primary tumors of the spine and spinal cord. Methods: An Institutional Review Board approved retrospective analysis of 30 patients with primary spine tumors treated at a single institution was performed. Post-treatment pain, neurological, and radiographic responses were the endpoints. Results: Nine patients were treated for benign tumors, and 21 patients were treated for malignant tumors...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/29657890/pain-flare-after-stereotactic-radiosurgery-for-spine-metastases
#3
Ehsan H Balagamwala, Mihir Naik, Chandana A Reddy, Lilyana Angelov, John H Suh, Toufik Djemil, Anthony Magnelli, Samuel T Chao
Purpose: Understanding of pain flare (PF) following spine stereotactic radiosurgery (sSRS) is lacking. This study sought to determine the incidence and risk factors associated with PF following single fraction sSRS. Materials/methods: An IRB-approved database was compiled to include patients who underwent sSRS. Patient and disease characteristics as well as treatment and dosimetric details were collected retrospectively. Pain relief post-sSRS was prospectively collected using the Brief Pain Inventory (BPI)...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/29657246/effects-of-three-forms-of-local-anesthesia-on-perioperative-fentanyl-induced-hyperalgesia
#4
Lu Chang, Fang Ye, Quehua Luo, Zewen Wang, Yimin Wang, Zhengyuan Xia, Haihua Shu
Both local infiltration analgesia (LIA) and nerve block are common analgesic modalities for pain relief after surgery. The aim of the current study was to investigate the effects of those two modalities on pain behavior and the expression of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6 and tumor necrosis factor-α (TNF-α) in the spinal cord and dorsal root ganglion (DRG) in a rat model of perioperative fentanyl induced hyperalgesia. Rats were injected with fentanyl (60 μg/kg) 4 times and received a plantar incision after the second injection or they received pre-incision LIA and sciatic nerve block (SNB) or post-incision LIA with levobupivacaine (0...
April 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29656173/factors-associated-with-extension-of-the-scheduled-time-for-spine-surgery
#5
Kazuyoshi Kobayashi, Kei Ando, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Naoki Ishiguro, Shiro Imagama
OBJECTIVES: Adherence to scheduled times in surgery is important in hospital management. However, sudden surgical changes or unexpected intraoperative problems may lead to prolongation of operative times. The purpose of this study was to investigate operative times in spinal surgery and to identify causes of delays during surgery. PATIENTS AND METHODS: A retrospective review of 488 cases of spinal surgery was performed to investigate operations prolonged for >2 h and to identify factors associated with prolongation...
April 3, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29649627/overexpression-of-hipk2-attenuates-spinal-cord-injury-in-rats-by-modulating-apoptosis-oxidative-stress-and-inflammation
#6
Renbo Li, Jingbo Shang, Wei Zhou, Li Jiang, Donghui Xie, Guanjun Tu
HIPK2 is considered to be a tumor suppressor. It also has been implicated in several functions such as apoptosis and inflammation that are linked to spinal cord injury (SCI). However, whether HIPK2 ameliorates the neurological pain of SCI remains unclear. Here, we investigated the effects of HIPK2 on neurological function, oxidative stress, levels of inflammatory cytokines and expression of Bcl-2/Bax in an SCI model. Firstly, we evaluated the therapeutic effects of HIPK2 on neurological pain in the SCI rat using the Basso, Beattie and Bresnahan scores and H & E staining...
April 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29623757/icariin-a-flavonoid-with-anti-cancer-effects-alleviated-paclitaxel-induced-neuropathic-pain-in-a-sirt1-dependent-manner
#7
Yulong Gui, Jie Zhang, Liang Chen, Shunyuan Duan, Jing Tang, Wei Xu, Aiyuan Li
Background One of the most common side effects of paclitaxel was dosage-dependently painful neuropathy. Various reports indicated that spinal neuroinflammation was involved in paclitaxel-induced neuropathic pain. This study investigated the effect of icariin on paclitaxel-induced neuroinflammation and peripheral neuropathy in rats. Methods Two parts were included in this study. In part one, the effect of icariin on paclitaxel-induced neuropathic pain was investigated. Mechanical thresholds were measured as primary outcomes...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29615371/intraluminal-brachytherapy-boost-following-external-beam-radiotherapy-with-concurrent-chemotherapy-of-oesophagus-carcinoma-results-of-a-prospective-observational-study
#8
P Nag, O P Gurjar, V Bhandari, K L Gupta, P Bagdare, H Goyal
PURPOSE: The main objective of our study is to evaluate response and toxicity profile in patients receiving external beam radiotherapy with concurrent chemotherapy followed by intraluminal brachytherapy boost for a carcinoma of the oesophagus. MATERIAL AND METHODS: Twenty patients with biopsy-proven carcinoma of the oesophagus received external beam radiotherapy (50Gy in 25 fractions) with concurrent chemotherapy (cisplatin: 40mg/m2 ). After a gap of two to three weeks, intraluminal brachytherapy (10Gy in two fractions each 1 week apart by a high dose rate60 Co source) was given...
March 31, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29614905/anti-inflammatory-effect-of-mongolian-drug-naru-3-on-traumatic-spinal-cord-injury-and-its-mechanism-of-action
#9
Bulin Baiyila, Bing He, Guisong He, Tengfei Long
Objective This study was performed to confirm the anti-inflammatory effect of the Mongolian drug Naru-3 on traumatic spinal cord injury (TSCI) and its possible mechanism of action. Methods We prepared a TSCI model using Sprague-Dawley rats. The rats were divided into a Naru-3 group and a methylprednisolone group. Real-time polymerase chain reaction and western blotting were performed to measure the expression levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β. Enzyme-linked immunosorbent assay kits were employed to detect serum inflammatory cytokine levels...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29614357/primary-spinal-cord-melanoma-a-case-report-and-a-systemic-review-of-overall-survival
#10
Mingzhe Zhang, Raynald Liu, Yi Xiang, Jianhui Mao, Guangjie Li, Ronghua Ma, Zhaosheng Sun
BACKGROUND: The incidence of primary spinal cord melanoma (PSCM) is very rare. Several case series and case reports have been published in the literature. However, the predictive factors of PSCM survival and management options are not discussed in detail. METHODS: We present a case of PSCM; total resection was achieved and chemotherapy was given post-operatively. A comprehensive search was performed on PubMed's electronic database using the words "primary spinal cord melanoma"...
March 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29613896/neoplastic-myelopathies
#11
Jing Wu, Surabhi Ranjan
PURPOSE OF REVIEW: This article discusses the diagnosis and management of neoplasms that affect the spinal cord as well as spinal cord disorders that can occur due to cancer treatments. RECENT FINDINGS: Neoplastic myelopathies are uncommon neurologic disorders but cause significant morbidity when they occur. Primary spinal cord tumors can be classified into intramedullary, intradural extramedullary, or extradural tumors. Diffuse gliomas and ependymal tumors are the most common intramedullary tumors...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29610439/soluble-tnf%C3%AE-signaling-within-the-spinal-cord-contributes-to-the-development-of-autonomic-dysreflexia-and-ensuing-vascular-and-immune-dysfunction-after-spinal-cord-injury
#12
Eugene Mironets, Patrick Osei-Owusu, Valerie Bracchi-Ricard, Roman Fischer, Elizabeth A Owens, Jerome Ricard, Di Wu, Tatiana Saltos, Eileen Collyer, Shaoping Hou, John R Bethea, Veronica J Tom
Cardiovascular disease and susceptibility to infection are leading causes of morbidity and mortality for individuals with spinal cord injury (SCI). A major contributor to these is autonomic dysreflexia (AD), an amplified reaction of the autonomic nervous system (hallmarked by severe hypertension) in response to sensory stimuli below the injury. Maladaptive plasticity of the spinal sympathetic reflex circuit below the SCI results in AD intensification over time. Mechanisms underlying this maladaptive plasticity are poorly understood, restricting the identification of treatments...
April 2, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29610008/surgical-outcomes-of-spinal-cord-and-cauda-equina-ependymoma-postoperative-motor-status-and-recurrence-for-each-who-grade-in-a-multicenter-study
#13
Kazuyoshi Kobayashi, Kei Ando, Fumihiko Kato, Tokumi Kanemura, Koji Sato, Mitsuhiro Kamiya, Yoshihiro Nishida, Naoki Ishiguro, Shiro Imagama
BACKGROUND: The goals of the study are to analyze postoperative outcomes and recurrence in cases of spinal cord and cauda equina ependymoma in each World Health Organization (WHO) Grade, and to examine the influence of extent of surgical removal on prognosis. Spinal ependymoma has a relatively high frequency among intramedullary spinal cord tumors. The tumor is classified in WHO guidelines as grades I, II, and III, but few studies have examined postoperative prognosis based on these grades...
March 30, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29607715/hedgehog-signaling-contributes-to-bone-cancer-pain-by-regulating-sensory-neuron-excitability-in-rats
#14
Su Liu, You Lv, Xin-Xin Wan, Zhi-Jing Song, Yue-Peng Liu, Shuai Miao, Guang-Lei Wang, Gong-Jian Liu
Treating bone cancer pain continues to be a clinical challenge and underlying mechanisms of bone cancer pain remain elusive. Here, we reported that sonic hedgehog signaling plays a critical role in the development of bone cancer pain. Tibia bone cavity tumor cell implantation produces bone cancer-related mechanical allodynia, thermal hyperalgesia, and spontaneous and movement-evoked pain behaviors. Production and persistence of these pain behaviors are well correlated with tumor cell implantation-induced up-regulation and activation of sonic hedgehog signaling in primary sensory neurons and spinal cord...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29607173/dosimetric-comparison-of-helical-tomotherapy-and-conventional-linac-based-x-knife-stereotactic-body-radiation-therapy-for-primary-lung-cancer-or-pulmonary-metastases
#15
Shuangshuang Li, Ju Yang, Juan Liu, Shanbao Gao, Baorui Liu, Jing Yan
Background: To compare helical tomotherapy (HT) with X-knife stereotactic body radiation therapy (HT-SBRT/X-SBRT) for primary or metastatic lung cancer regarding planning target volume (PTV) coverage, such as homogeneity index (HI), conformity index (CI) and dose-volume histogram (DVH) of organs at risk (OARs). Methods: We retrospectively analyzed 21 patients receiving definitive radiation treatment for non-small cell lung cancer (NSCLC) or pulmonary metastases at our institution between March 2015 and October 2016...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29602827/machine-learning-improves-diagnosis-of-cns-cancers
#16
(no author information available yet)
A new machine-learning algorithm that recognizes patterns in genome-wide DNA-methylation data can help pathologists classify brain and spinal cord tumors. The diagnostic tool is freely available online, and could prove valuable for histologically ambiguous cases.
March 30, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29600414/metastatic-epidural-spinal-cord-compression-does-timing-of-surgery-influence-the-chance-of-neurological-recovery-an-observational-case-control-study
#17
Valerio Pipola, Silvia Terzi, Giuseppe Tedesco, Stefano Bandiera, Giovanni Barbanti Bròdano, Riccardo Ghermandi, Gisberto Evangelisti, Marco Girolami, Alessandro Gasbarrini
PURPOSE: Metastatic epidural spinal cord compression (MESCC) is radiologically defined as an epidural metastatic lesion causing the displacement of the spinal cord from its normal position in the vertebral canal. The purpose of this paper is the evaluation of the influence of timing of surgery on the chance of neurological recovery. METHODS: This is a retrospective observational case-control study performed on patients with MESCC from solid tumors surgically treated at our institute from January 2010 to December 2016...
March 30, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29599982/solitary-primary-intracranial-leptomeningeal-glioblastoma-invading-the-normal-cortex-case-report
#18
Takamichi Katsuhara, Nobuhiro Moro, Takashi Ohta, Taku Homma, Atsuo Yoshino
Solitary primary intracranial leptomeningeal glioma (PLG) is a rare entity of glioma. PLG arises from the heterotopic glial tissue in the subarachnoid space and usually grows there without parenchymal invasion. The present study reported a case of solitary PLG, pathologically diagnosed as glioblastoma, that invaded the temporal cortex and finally disseminated to the spinal cord. A 55-year-old woman had headaches and visited Nihon University, Itabashi Hospital. Head magnetic resonance imaging showed a solid mass mainly located in the right middle fossa extending to the frontal base with strong enhancement effect after contrast medium injection...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29596155/mir-221-alleviates-the-inflammatory-response-and-cell-apoptosis-of-neuronal-cell-through-targeting-tnfaip2-in-spinal-cord-ischemia-reperfusion
#19
Dong Zhao, Shu-Cai Deng, Yi Ma, Yong-Hong Hao, Zhan-Hua Jia
This study aimed to examine the role of miR-221 in inflammatory response and apoptosis of neuronal cells after spinal cord ischemia/reperfusion (I/R) injury. Blood samples were obtained from 20 I/R patients and that of 20 healthy individuals were used as a control. AGE1.HN and SY-SH-5Y neuronal cell lines subjected to oxygen-glucose deprivation (OGD) stress were used in cell experiments. Real-time PCR and western blot were used to evaluate the expression of miR-221, tumor necrosis factor-α, and TNFAIP2. TUNEL assay analyzed cell apoptosis...
March 28, 2018: Neuroreport
https://www.readbyqxmd.com/read/29581891/multifocal-primary-melanoma-of-the-cervical-spinal-cord-successfully-treated-by-tumorectomy-a-case-report
#20
Takahito Iga, Akio Iwanami, Takeru Funakoshi, Shuji Mikami, Osahiko Tsuji, Narihito Nagoshi, Eijiro Okada, Nobuyuki Fujita, Mitsuru Yagi, Kota Watanabe, Masaya Nakamura, Morio Matsumoto
Introduction: Multifocal primary melanoma of the spine is extremely rare. Here, we report a case of multifocal primary melanoma of the cervical spinal cord. Case presentation: A 39-year-old man presented with a 1-year history of numbness of the upper extremities and back. Magnetic resonance imaging of the cervical spine suggested multifocal intradural extramedullary tumors at levels C2 and C4-C5. A diagnostic biopsy revealed a pathological diagnosis of malignant melanoma...
2018: Spinal Cord Series and Cases
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