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Spinal cord tumor

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https://www.readbyqxmd.com/read/29456358/surgically-treated-primary-spinal-cord-neoplasms-in-southeastern-nigeria
#1
Mark Chukwunweike Chikani, Okwuoma Okwunodulu, Mathew Mesi, Wilfred C Mezue, Samuel C Ohaegbulam, Chika C Ndubuisi
Background: Primary spinal cord tumors are not as frequently encountered as their cranial counterparts. They could present in such an indolent manner that requires a reasonable index of suspicion for their diagnosis to be considered. Objective: The objective of this study is to analyze the incidence and pattern of primary spinal cord and appendage neoplasms in patients surgically treated in our institution over a decade of practice. Materials and Methods: A retrospective review of clinical, radiological, and histopathology profiles of patients surgically treated for primary spinal cord tumor from 2006 to 2016 was carried out...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29455369/intradural-spinal-tumors-in-adults-update-on-management-and-outcome
#2
REVIEW
Malte Ottenhausen, Georgios Ntoulias, Imithri Bodhinayake, Finn-Hannes Ruppert, Stefan Schreiber, Annette Förschler, John A Boockvar, Andreas Jödicke
Among spinal tumors that occur intradurally, meningiomas, nerve sheath tumors, ependymomas, and astrocytomas are the most common. While a spinal MRI is the state of the art to diagnose intradural spinal tumors, in some cases CT scans, angiography, CSF analyses, and neurophysiological examination can be valuable. The management of these lesions depends not only on the histopathological diagnosis but also on the clinical presentation and the anatomical location, allowing either radical resection as with most extramedullary lesions or less invasive strategies as with intramedullary lesions...
February 17, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29454959/exophytic-cerebral-hemispheric-low-grade-glioma-an-unusual-growth-pattern-of-a-common-central-nervous-system-tumour
#3
Suyash Singh, Kuntal Kanti Das, Sushila Jaiswal, Raj Kumar
BACKGROUND: Exophytic growth (EG), where in the tumor mass grows beyond the neuraxial boundary formed by pia mater, remains a rare pattern of glioma growth. It has been described in gliomas at several locations like the brainstem, cerebellum, suprasellar area, spinal cord and the insula. However, EG in hemispheric grade 2 astrocytomas, particularly affecting the convexity subarachnoid space, as against the more spacious basal subarachnoid space, is exceedingly rare. To the best of our knowledge, there is only one such case reported in the English literature...
February 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29453346/anti-inflammatory-effect-of-tauroursodeoxycholic-acid-in-raw-264-7-macrophages-bone-marrow-derived-macrophages-bv2-microglial-cells-and-spinal-cord-injury
#4
Seong Jun Kim, Wan-Kyu Ko, Min-Jae Jo, Yoshie Arai, Hyemin Choi, Hemant Kumar, In-Bo Han, Seil Sohn
This study aimed to investigate the anti-inflammatory effects of tauroursodeoxycholic acid (TUDCA) after spinal cord injury (SCI) in rats. We induced an inflammatory process in RAW 264.7 macrophages, BV2 microglial cells, and bone marrow-derived macrophages (BMM) using lipopolysaccharide (LPS). The anti-inflammatory effects of TUDCA on LPS-stimulated RAW 264.7 macrophages, BV2 microglial cells, and BMMs were analyzed using nitric oxide (NO) assays, quantitative real-time polymerase chain reactions (qRT-PCR), and enzyme-linked immunosorbent assays (ELISA)...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29451456/clival-meningocele-causing-bilateral-hearing-loss-in-a-child-due-to-superficial-siderosis-of-the-central-nervous-system-case-report
#5
Stephen J Johans, Kevin N Swong, Daniel J Burkett, Michael P Wemhoff, Sean M Lew, Chirag R Patel, Anand V Germanwala
Superficial siderosis (SS) of the CNS is a rare and often unrecognized condition. Caused by hemosiderin deposition from chronic, repetitive hemorrhage in the subarachnoid space, it results in parenchymal damage in the subpial layers of the brain and spinal cord. T2-weighted MRI shows the characteristic hypointensity of hemosiderin deposition, classically occurring around the cerebellum, brainstem, and spinal cord. Patients present with progressive gait ataxia and sensorineural hearing impairment. Although there have been several studies, case reports, and review articles over the years, the clear pathophysiology of subarachnoid space hemorrhage remains to be elucidated...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29451451/critical-assessment-of-pediatric-neurosurgery-patient-parent-educational-information-obtained-via-the-internet
#6
Michael Garcia, Christopher Daugherty, Bertha Ben Khallouq, Todd Maugans
OBJECTIVE The Internet is used frequently by patients and family members to acquire information about pediatric neurosurgical conditions. The sources, nature, accuracy, and usefulness of this information have not been examined recently. The authors analyzed the results from searches of 10 common pediatric neurosurgical terms using a novel scoring test to assess the value of the educational information obtained. METHODS Google and Bing searches were performed for 10 common pediatric neurosurgical topics (concussion, craniosynostosis, hydrocephalus, pediatric brain tumor, pediatric Chiari malformation, pediatric epilepsy surgery, pediatric neurosurgery, plagiocephaly, spina bifida, and tethered spinal cord)...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29451217/neuroprotective-mechanisms-of-rutin-for-spinal-cord-injury-through-anti-oxidation-and-anti-inflammation-and-inhibition-of-p38-mitogen-activated-protein-kinase-pathway
#7
Hong-Liang Song, Xiang Zhang, Wen-Zhao Wang, Rong-Han Liu, Kai Zhao, Ming-Yuan Liu, Wei-Ming Gong, Bin Ning
Rutin has anti-inflammatory, antioxidant, anti-viral, anti-tumor and immune regulatory effects. However, the neuroprotective effects of rutin in spinal cord injury are unknown. The p38 mitogen activated protein kinase (p38 MAPK) pathway is the most important member of the MAPK family that controls inflammation. We assumed that the mechanism of rutin in the repair of spinal cord injury is associated with the inhibition of p38 MAPK pathway. Allen's method was used to establish a rat model of spinal cord injury...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29444083/high-fat-diet-sensitizes-fibromyalgia-like-pain-behaviors-in-mice-via-tumor-necrosis-factor-alpha
#8
Dan Tian, Miao Tian, Leilei Zhang, Peng Zhao, Yunfeng Cui, Jinlong Li
Fibromyalgia (FM) and obesity are closely related. However, little is known about how obesity contributes to FM. Importantly, adequate evidence has shown that tumor necrosis factor alpha (TNF-α) plays a critical role in obesity. Thus, we hypothesized that obesity-induced TNF-α release may potentiate FM-associated pain. To test this hypothesis, we investigated the role of TNF-α in the development of FM-like pain in a mouse model of acid saline injection-induced FM. Consistent with previous reports, we showed that repeated acid saline injections induced bilateral mechanical hyperalgesia, and this effect lasted for at least 4 days after acid saline injections...
2018: PloS One
https://www.readbyqxmd.com/read/29439906/dermoid-cysts-of-the-conus-medullaris-clinical-review-case-series-and-management-strategies
#9
Salah G Aoun, Mary Ashley Liu, Megan Still, Tarek Y El Ahmadieh, Mazin Al Tamimi, Wayne Gluf
BACKGROUND: The management of dermoid cysts can be tedious as they have a tendency to recur, and respond poorly to chemotherapy and radiation. Management is especially difficult for tumors involving highly eloquent areas such as the conus medullaris. OBJECTIVE: We aim to provide a summary of the pathology, clinical presentation, and operative management strategies of dermoid cysts involving the conus medullaris. METHODS: Two clinical cases of dermoid cysts of the conus are presented, as well as a commented surgical video...
February 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29436632/sparstolonin-b-attenuates-spinal-cord-injury%C3%A2-induced-inflammation-in-rats-by-modulating-tlr4%C3%A2-trafficking
#10
Jianjun Yuan, Xueli Zhang, Rusen Zhu, Zijian Cui, Wei Hu
The present study used a spinal cord injury (SCI) model to evaluate whether sparstolonin B was able to prevent SCI, and to investigate the underlying signaling mechanism. Sparstolonin B attenuated the SCI‑induced Batto, Beattie and Bresnahan score and water content in rats. Sparstolonin B attenuated the mRNA expression of proinflammatory cytokines interleukin (IL)‑18, IL‑6, IL‑1β, and IL‑23, decreased the levels of tumor necrosis factor‑α and interferon‑γ, and decreased caspase‑3 activity and apoptosis regulator Bax protein expression in SCI rats...
February 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436581/the-pi3k-akt-foxo3a-pathway-regulates-regeneration-following-spinal-cord-injury-in-adult-rats-through-tnf-%C3%AE-and-p27kip1-expression
#11
Honghui Lu, Li-Hai Zhang, Lin Yang, Pei-Fu Tang
The aim of the present study was to elucidate the expression and role of the phosphatidylinositol 3‑kinase (PI3K)/Akt/forkhead box O3 (FOXO3a) pathway in the regeneration of the spinal cord following spinal cord injury (SCI), and its regulatory effect on tumor necrosis factor (TNF)-α and cyclin-dependent kinase inhibitor 1B (p27kip1) expression. Firstly, in a Sprague-Dawley rat model of SCI, western blot analysis revealed that the protein levels of PI3K, phosphorylated Akt and FOXO3a were markedly inhibited compared with those in the sham control group...
February 6, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29434866/logistic-regression-analysis-of-risk-factors-for-postoperative-recurrence-of-spinal-tumors-and-analysis-of-prognostic-factors
#12
Shanyong Zhang, Lili Yang, Chuangang Peng, Minfei Wu
The aim of the present study was to investigate the risk factors for postoperative recurrence of spinal tumors by logistic regression analysis and analysis of prognostic factors. In total, 77 male and 48 female patients with spinal tumor were selected in our hospital from January, 2010 to December, 2015 and divided into the benign (n=76) and malignant groups (n=49). All the patients underwent microsurgical resection of spinal tumors and were reviewed regularly 3 months after operation. The McCormick grading system was used to evaluate the postoperative spinal cord function...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29430662/on-the-feasibility-of-automatically-selecting-similar-patients-in-highly-individualized-radiotherapy-dose-reconstruction-for-historic-data-of-pediatric-cancer-survivors
#13
Marco Virgolin, Irma W E M van Dij, Jan Wiersma, Cécile M Ronckers, Cees Witteveen, Arjan Bel, Tanja Alderliesten, Peter A N Bosman
PURPOSE: The aim of this study is to establish the first step towards a novel and highly individualized 3D dose distribution reconstruction method, based on CT scans and organ delineations of recently treated patients. Specifically, the feasibility of automatically selecting the CT scan of a recently treated childhood cancer patient who is similar to a given historically treated child who suffered from Wilms' tumor is assessed. METHODS: A cohort of 37 recently treated children between 2 and 6 years old is considered...
February 12, 2018: Medical Physics
https://www.readbyqxmd.com/read/29429794/treatment-plan-quality-and-delivery-accuracy-assessments-on-3-imrt-delivery-methods-of-stereotactic-body-radiotherapy-for-spine-tumors
#14
Long Huang, Toufik Djemil, Tingliang Zhuang, Martin Andrews, Samuel T Chao, John H Suh, Ping Xia
Stereotactic body radiotherapy (SBRT) for spine tumors has demonstrated clinical effectiveness. The treatment planning and delivery techniques have evolved from dynamic conformal arc therapy, to fixed gantry angle intensity modulated radiotherapy (IMRT), and most recently to volumetric modulated arc therapy (VMAT). A hybrid-arc (HARC) planning and delivery method combining dynamic conformal arc therapy delivery with a number of equally spaced IMRT beams is proposed. In this study we investigated plan quality, delivery accuracy, and efficiency of 3 delivery techniques: IMRT, HARC, and VMAT...
February 8, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29429785/spinal-primary-central-nervous-system-lymphoma-case-report-and-literature-review
#15
REVIEW
Li Feng, Dingbang Chen, Hongyan Zhou, Cunzhou Shen, Haiyan Wang, Xunsha Sun, Xiulin Liang, Ling Chen
Primary central nervous system lymphoma (PCNSL) is a very rare tumor of increasing incidence. It is often misdiagnosed due to the unspecific presentation or unavailable biopsy, and results in poor prognosis. PCNSL involved the spinal cord is extremely sparse. Here we report a gentleman presented with one-year history of progressive tremor in the left limbs and slight dysarthria as well as three-month history of paraparesis, tinnitus and insomnia. MR images disclosed the swollen cerebellum and cauda equine, with contrast enhancement in both meninges and nerve roots...
February 8, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29428215/spinal-pkc-activation-induced-neuronal-hmgb1-translocation-contributes-to-hyperalgesia-in-a-bone-cancer-pain-model-in-rats
#16
Kang An, Hui Rong, Huadong Ni, Chunyan Zhu, Longsheng Xu, Qianying Liu, Yajing Chen, Ying Zheng, Bing Huang, Ming Yao
Bone cancer pain (BCP) remains a serious complication of malignancy, which is an intractable clinical problem due to the gap in knowledge of its underlying mechanisms. Recent studies have demonstrated that the major involvement of neuroinflammation, particularly high-mobility group box 1 (HMGB1), which was identified as a late mediator of inflammation, in a number of pain conditions. However, the underlying mechanisms and functions of HMGB1 release in spinal cord, and its contributions to the development of BCP as well, are poorly understood...
February 8, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29427814/management-and-survival-of-adult-patients-with-pilocytic-astrocytoma-in-the-national-cancer-database
#17
Kevin J Lee, Eduardo Marchan, Jennifer Peterson, Anna C Harrell, Alfredo Quinones-Hinojosa, Paul D Brown, Daniel M Trifiletti
PURPOSE/OBJECTIVES: Adult pilocytic astrocytomas (PA) are relatively rare central nervous system (CNS) tumors with a favorable prognosis. We sought to investigate existing clinical management strategies and overall survival (OS) as a function of various clinical characteristics among adult patients with PA. METHODS/MATERIALS: All patients over age 18 years, diagnosed with CNS pilocytic astrocytomas from 2004-2014 in the National Cancer Database were included. Clinical and treatment-related characteristics were recorded and analyzed for an association with OS following diagnosis using univariate and multivariate analyses...
February 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29426358/optimizing-the-prescription-isodose-level-in-stereotactic-volumetric-modulated-arc-radiotherapy-of-lung-lesions-as-a-potential-for-dose-de-escalation
#18
Mark Chan, Matthew Wong, Ronnie Leung, Steven Cheung, Oliver Blanck
BACKGROUND: To derive and exploit the optimal prescription isodose level (PIL) in inverse optimization of volumetric modulated arc radiotherapy (VMAT) as a potential approach to dose de-escalation in stereotactic body radiotherapy for non-small cell lung carcinomas (NSCLC). METHODS: For ten patients, inverse Monte Carlo dose optimization was performed to cover 95% PTV by varying prescription isodose lines (PIL) at 60 to 80% and reference 85%. Subsequently, these were re-normalized to the median gross tumor volume dose (GTV-based prescription) to assess the impacts of PTV and normal tissue dose reduction...
February 9, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29423312/epidemiological-profile-of-spinal-cord-injuries-at-a-tertiary-rehabilitation-center-in-kuwait
#19
L Prasad, S Al Kandari, U Ramachandran, D Shehab, S Alghunaim
Study design: Retrospective, descriptive study. Objective: To describe the epidemiological profile of patients with spinal cord injury (SCI) in Kuwait. Setting: Physical Medicine and Rehabilitation Hospital, Kuwait. Methods: Review of medical records of 241 adult patients with SCI admitted during the period 2010-2015. The data collected included gender, age, etiology, neurological and vertebral level of injury and American Spinal Injury Association impairment scale (AIS)...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29422366/ossified-extradural-en-plaque-meningioma-of-the-cervical-spine
#20
Koichiro Sakamoto, Satoshi Tsutsumi, Senshu Nonaka, Takamoto Suzuki, Hisato Ishii, Masanori Ito, Yukimasa Yasumoto
A 57-year-old woman sustained gradually progressive sensorimotor disturbance in the left upper extremity for one year. Neurological examination found a diminished sensation below the left C7 dermatome and reduced strength in the left interosseous muscles. Computed tomography of the cervical spine revealed a high density mass at C7, in the left dorsal part of the spinal canal. Magnetic resonance imaging found an enhancing, en-plaque tumor at C6-T1, involving a non-enhancing part, and considerable compression of the spinal cord...
February 5, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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