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https://www.readbyqxmd.com/read/29784673/formation-of-the-sacrum-requires-down-regulation-of-sonic-hedgehog-signaling-in-the-sacral-intervertebral-discs
#1
Raffaella Bonavita, Kathleen Vincent, Robert Pinelli, Chitra Lekha Dahia
In humans, the sacrum forms an important component of the pelvic arch, and it transfers the weight of the body to the lower limbs. The sacrum is formed by collapse of the intervertebral discs (IVDs) between the five sacral vertebrae during childhood, and their fusion to form a single bone. We show that collapse of the sacral discs in the mouse is associated with the down-regulation of sonic hedgehog (SHH) signaling in the nucleus pulposus (NP) of the disc, and many aspects of this phenotype can be reversed by experimental postnatal activation of HH signaling...
May 21, 2018: Biology Open
https://www.readbyqxmd.com/read/29772857/-posterior-spinal-canal-decompression-with-screw-fixation-and-reconstruction-of-three-vertebral-column-for-thoracolumbar-burst-fractures-complicated-with-nerve-injury
#2
Li-Yong Wu, Xue-Mei Huang, Yue Wang, Zhao-Bo Yang, Sheng-Hui Su, Chun Wang
OBJECTIVE: To explore the feasibility and clinical effect of posterior spinal canal decompression with pedicle screw fixation and reconstruction of anterior and middle vertebral column for thoracolumbar burst fractures complicated with nerve injury. METHODS: A total of 36 patients with thoracolumbar burst fractures treated from March 2011 to April 2016 were enrolled in the retrospective study. There were 20 males and 16 females, aged from 21 to 52 years old with an average of 37...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29770586/surgical-infection-after-posterolateral-lumbar-spine-arthrodesis-ct-analysis-of-spinal-fusion
#3
Pablo Andrés-Cano, Ana Cerván, Miguel Rodríguez-Solera, Jose Antonio Ortega, Natividad Rebollo, Enrique Guerado
OBJECTIVE: To determine the incidence of infection after instrumented lumbar spine surgery, the demographic and surgical variables associated with acute infection, and the influence of infection and debridement on the consolidation of spinal fusion. METHODS: After obtaining approval from the hospital ethics committee, an observational study was made on a prospective cohort of consecutive patients surgically treated by posterolateral lumbar spine arthrodesis (n = 139, 2005-2011)...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29770280/effect-of-body-mass-index-on-perioperative-outcomes-in-minimally-invasive-oblique-lateral-lumbar-interbody-fusion-versus-open-fusions-a-multivariant-analysis
#4
Hamid Abbasi, Alex Grant
Background Obesity is an increasing public health concern associated with increased perioperative complications and expense in lumbar spine fusions. While open and mini-open fusions such as transforaminal lumbar interbody fusion (TLIF) and minimally invasive TLIF (MIS-TLIF) are more challenging in obese patients, new MIS procedures like oblique lateral lumbar interbody fusion (OLLIF) may improve perioperative outcomes in obese patients relative to TLIF and MIS-TLIF. Purpose The purpose of this study is to determine the effects of obesity on perioperative outcomes in OLLIF, MIS-TLIF, and TLIF...
March 8, 2018: Curēus
https://www.readbyqxmd.com/read/29770178/dynamic-stabilization-for-degenerative-diseases-in-the-lumbar-spine-2-years-results
#5
Ahmed Hosny Khalifa, Timo Stübig, Oliver Meier, Christian Walter Müller
Following lumbar fusion, adjacent segment degeneration has been frequently reported. Dynamic systems are believed to reduce main fusion drawbacks. We conducted a retrospective study on patients with degenerative lumbar disease treated with posterior dynamic stabilization with monoaxial hinged pedicular screws and lumbar decompression. VAS and ODI were used to compare clinical outcomes. As radiological outcomes, LL and SVA were used. 51 patients were included with an average follow-up of 24 months. 13 patients were revised because of postoperative radiculopathy (n=4), subcutaneous hematoma (n=2), L5 screw malposition (n=1) and adjacent segment disease (n=6)...
March 29, 2018: Orthopedic Reviews
https://www.readbyqxmd.com/read/29766939/minimally-invasive-options-for-surgical-management-of-adjacent-segment-disease-of-the-lumbar-spine
#6
Mazda K Turel, Mena G Kerolus, Brian T David, Richard G Fessler
Background: The incidence of adjacent segment disease (ASD) after lumbar spine surgery is a condition that has become increasingly common as the rate of lumbar spine surgery continues to rise. Minimally invasive techniques continue to be refined and offer an opportunity to treat ASD with minimal tissue disruption, lower blood loss, a shorter hospital stay, and decreased morbidity. The aim of this report is to describe the various minimally invasive options for ASD with a comprehensive review of the existing literature...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29766758/anti-inflammatory-peptide-attenuates-edema-and-promotes-bmp-2-induced-bone-formation-in-spine-fusion
#7
Juliane D Glaeser, Khosrowdad Salehi, Linda Kanim, Dmitriy Sheyn, Zachary NaPier, Phillip Behrens, Leslie Garcia, Jason M Cuéllar, Hyun W Bae
Recombinant human bone morphogenic protein-2 (BMP-2) loaded absorbable collagen sponges (ACS) have been successfully used to enhance bone formation and to induce spinal fusion in humans. However, side effects, such as soft-tissue edema and inflammation, have been reported. NEMO binding domain peptide (NBD) inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a central regulator of immune response. In this study, we investigated NBD's potential to reduce BMP-2-induced soft-tissue inflammation without affecting BMP-2-mediated spinal fusion in rat...
May 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29763982/bone-graft-in-posterior-spine-fusion-for-adolescent-idiopathic-scoliosis-a-meta-analysis
#8
REVIEW
Nathan Kirzner, Luke Hilliard, Catherine Martin, Gerald Quan, Susan Liew, Ali Humadi
BACKGROUNDS: The aim of this study was to systematically analyse and perform a meta-analysis on the current available literature comparing the fusion rates and complications associated with use of autograft, allograft and bone substitutes to supplement posterior spinal fusion for adolescent idiopathic scoliosis (AIS). METHODS: The electronic databases including Embase, PubMed, Medline, Cinahl and Cochrane Library were searched to identify relevant studies. A total of 12 studies with 2389 patients were included for meta-analysis...
May 15, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29762284/hss-dysphagia-and-dysphonia-inventory-hss-ddi-following-anterior-cervical-fusion-patient-derived-validated-condition-specific-patient-reported-outcome-measure-outperforms-existing-indices
#9
Alexander P Hughes, Stephan N Salzmann, Okezie K Aguwa, Courtney Ortiz Miller, Roland Duculan, Jennifer Shue, Frank P Cammisa, Andrew A Sama, Federico P Girardi, Ashutosh Kacker, Carol A Mancuso
BACKGROUND: Dysphagia and dysphonia are common complications after anterior cervical spine surgery; however, reported prevalences vary greatly due to a lack of reliable clinical standards for measuring postoperative swallowing and speech dysfunction. The Hospital for Special Surgery Dysphagia and Dysphonia Inventory (HSS-DDI) was developed as a patient-derived, patient-reported instrument to measure dysphagia and dysphonia more accurately after anterior cervical spine surgery than existing indices...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29755238/cervical-sagittal-balance-parameters-after-single-level-anterior-cervical-discectomy-and-fusion-correlations-with-clinical-and-functional-outcomes
#10
Ioannis Siasios, Evan Winograd, Asham Khan, Kunal Vakharia, Vassilios G Dimopoulos, John Pollina
Background: Normal sagittal cervical alignment has been associated with improved outcome after anterior cervical discectomy and fusion (ACDF). Objective: The aim of this study is to identify alterations of cervical sagittal balance parameters after single-level ACDF and assess correlations with postoperative functionality. Methods: A retrospective chart review was performed between January 2010 and January 2014 to identify adult patients with no previous cervical spine surgery who underwent ACDF at any one level between C2 and C7 for the single-level degenerative disease...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29753275/cervical-spine-fracture-through-a-cervical-disc-replacement
#11
M Flanagan, D T Cawley, N Cassidy
INTRODUCTION: We report a rare case of cervical spine trauma through a cervical disc replacement and adjacent multilevel disc fusions. Cervical disc replacement (CDR) is a viable option for the surgical treatment of degenerative disc disease however long term follow up data regarding this operative technique is poor specifically relating to traumatic complications. We know of no previous reports of bilateral cervical pedicle fractures occurring adjacent to CDR and anterior cervical spine instrumentation...
March 29, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29752555/minimally-invasive-surgery-procedure-in-isthmic-spondylolisthesis
#12
Francesco Ciro Tamburrelli, Maria Concetta Meluzio, Aaron Burrofato, Andrea Perna, Luca Proietti
PURPOSE: The aim of the study was to evaluate the efficacy and safety of the direct lateral approach to the lumbar spine in the treatment of painful isthmic spondylolisthesis in adults. METHODS: Twenty-one patients affected by isthmic spondylolisthesis and treated with extreme lateral interbody fusion and posterior percutaneous pedicle screw fixation were enrolled. All included patients were clinically evaluated with Oswestry Disability Index, SF36 and Visual Scale Anatomy (VAS) for back pain at 1, 3 months and at 1 year...
May 11, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29748903/sagittal-classification-in-adolescent-idiopathic-scoliosis-original-description-and-therapeutic-implications
#13
K Abelin-Genevois, D Sassi, S Verdun, P Roussouly
INTRODUCTION: Surgical treatment of AIS aims to correct the coronal and sagittal alignment of the spine. The global alignment of the spine may be normalized through reciprocal changes between the fused spine and adjacent segments. We propose a new classification system describing the specific sagittal patterns induced by AIS to define reproducible guidelines for the surgical strategy. METHODS: We analyzed 100 consecutive AIS patients aged between 12 and 18 years candidate for spinal fusion...
May 10, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29748100/impact-of-magnetic-resonance-imaging-on-gross-tumor-volume-delineation-in-non-spine-bony-metastasis-treated-with-stereotactic-body-radiation-therapy
#14
Srinivas Raman, Lee Chin, Darby Erler, Eshetu G Atenafu, Patrick Cheung, William Chu, Hans Chung, Andrew Loblaw, Ian Poon, Joel Rubenstein, Hany Soliman, Arjun Sahgal, Chia-Lin Tseng
PURPOSE: This study investigates the inter-observer variability of contouring non-spine bone metastases using the planning CT alone vs. the addition of MRI T1 and T2 imaging sequences. METHODS AND MATERIALS: 10 cases of non-spine bone metastases treated with SBRT at our institution were selected. The gross tumor volume (GTV) for each case was delineated by six SBRT radiation oncologists (RO) and one diagnostic radiologist (DR) on the treatment planning CT. After a minimum of three months, each case was re-contoured on the CT fused with a MRI T1 sequence followed by a MRI T2 sequence...
March 17, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29746962/posterior-spinal-surgery-for-adolescent-idiopathic-scoliosis-does-not-induce-compensatory-increases-in-distal-adjacent-segment-motion-a-prospective-gait-analysis-study
#15
R M Holewijn, I Kingma, M de Kleuver, N L W Keijsers
BACKGROUND CONTEXT: Adolescent idiopathic scoliosis (AIS) patients perform surprisingly well after spinal correction and fusion. It was previously hypothesized that, during gait, certain mechanisms compensate for the loss in spinal motion. Still, previous studies could not identify such compensatory mechanisms in the lower body. PURPOSE: This study aims to test the hypothesis of a compensatory increased motion of the distal unfused part of the spine during gait after posterior spinal correction and fusion...
May 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29738859/analysis-of-a-unilateral-bridging-cage-for-lumbar-interbody-fusion-2-year-clinical-results-and-fusion-rate-with-a-focus-on-subsidence
#16
Nicolas Heinz von der Hoeh, Tomaso Villa, Fabio Galbusera Galbusera, Anna Voelker, Ulrich A Spiegl, Jan-Sven Jarvers, Christoph-Eckhard Heyde
PURPOSE: The aim of this study was to evaluate the biomechanical stability and the clinical and radiographic outcomes of patients undergoing transforaminal lumbar interbody fusion (TLIF) using an oblique bridging cage with a particular focus on subsidence. METHODS: Finite element models (FEMs) were developed to compare the biomechanics of the oblique cage with conventional PLIF and banana-shaped cages with TLIF. Additionally, a retrospective review of a prospective collected database was performed to investigate the clinical and radiological results with a focus on the subsidence rate using an oblique polyetheretherketone (PEEK) cage with a bicortical load-bearing design...
May 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29738366/effects-of-combined-magnetic-fields-treatment-and-nano-hydroxyapatite-coating-on-porous-biphasic-calcium-phosphate-bone-graft-in-rabbit-spinal-fusion-model
#17
Xianglong Zhuo, Chentian Li, Bing Li, Zhaoyang Li, Hongbin Lv, Jianjun Huang, Daqi Xu, Jianzhong Hu
STUDY DESIGN: An animal experimental study was designed to investigate the efficacy of combined magnetic fields (CMF) treatment and nano-hydroxyapatite (HA) coating in the biphasic calcium phosphate (BCP) graft in posterolateral lumbar fusion. OBJECTIVE: To evaluate the effects of CMF treatment and nano-HA/BCP and their combination effect in posterolateral lumbar fusion. SUMMARY OF BACKGROUND DATA: Enhancement of artificial bone graft bioeffects could improve spinal fusion outcomes...
June 1, 2018: Spine
https://www.readbyqxmd.com/read/29736802/management-of-aortic-injury-during-minimally-invasive-lateral-lumbar-interbody-fusion
#18
REVIEW
Michael M Safaee, Devin Zarkowsky, Charles M Eichler, Murat Pekmezci, Aaron J Clark
PURPOSE: Minimally invasive lateral approaches to the lumbar spine allow for interbody fusion with good visualization of the disk space, minimal blood loss, and decreased length of stay. Major neurologic, vascular, and visceral complications are rare with this approach; however, the steps in management for severe vascular injuries are not well defined. We present a case report of aortic injury during lateral interbody fusion and discuss the use of endovascular repair. METHODS: This study is a case report of an intraoperative aortic injury...
May 7, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29735136/assessment-of-coronal-spinal-alignment-for-adult-spine-deformity-cases-after-intraoperative-t-square-shaped-use
#19
Swamy Kurra, Umesh Metkar, Henaku Yirenkyi, Richard A Tallarico, William F Lavelle
STUDY DESIGN: Retrospectively reviewed surgeries between 2011 and 2015 of patients who underwent posterior spinal deformity instrumentation with constructs involving fusions to pelvis and encompassing at least five levels. OBJECTIVE: Measure the radiographic outcomes of coronal malalignment (CM) after use of an intraoperative T square shaped instrument in posterior spinal deformity surgeries with at least five levels of fusion and extension to pelvis. BACKGROUND: Neuromuscular children found to benefit from intraoperative T square technique to help achieve proper coronal spinal balance with extensive fusions...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29735128/the-relationship-between-apical-vertebral-rotation-and-truncal-rotation-in-adolescent-idiopathic-scoliosis-using-3d-reconstructions
#20
Pawel P Jankowski, Burt Yaszay, Krishna R Cidambi, Carrie E Bartley, Tracey P Bastrom, Peter O Newton
STUDY DESIGN: Retrospective review of prospective data. OBJECTIVES: To evaluate the relationship between absolute apical vertebral rotation (AVR) evaluated with upright 3D imaging and angle of trunk rotation (ATR) before and after surgery for thoracic and lumbar curves in adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: New imaging technology allows for improved radiographic assessment of the degree of AVR pre- and postoperatively through 3D spine models created from biplanar, simultaneous spine radiographs...
May 2018: Spine Deformity
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