Amaia Navarro-Corcuera, Tejasav S Sehrawat, Nidhi Jalan-Sakrikar, Hunter R Gibbons, Nicholas E Pirius, Shalil Khanal, Feda H Hamdan, Sayed Obaidullah Aseem, Sheng Cao, Jesus M Banales, Ningling Kang, William A Faubion, Nicholas F LaRusso, Vijay H Shah, Robert C Huebert
BACKGROUND & AIMS: Biliary disease is associated with a proliferative/fibrogenic ductular reaction (DR). p300 is an epigenetic regulator that acetylates lysine 27 on histone 3 (H3K27ac) and is activated during fibrosis. Long non-coding RNAs (lncRNAs) are aberrantly expressed in cholangiopathies, but little is known about how they recruit epigenetic complexes and regulate DR. We investigated epigenetic complexes, including transcription factors (TFs) and lncRNAs, contributing to p300-mediated transcription during fibrosis...
April 2022: Journal of Hepatology