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Docetaxel and nanoparticles

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https://www.readbyqxmd.com/read/29123392/self-assembled-albumin-nanoparticles-for-combination-therapy-in-prostate-cancer
#1
Huibo Lian, Jinhui Wu, Yiqiao Hu, Hongqian Guo
Resistance to regular treatment strategies is a big challenge in the treatment of castration-resistant prostate cancer. Combination of photothermal and photodynamic therapy (PTT/PDT) with chemotherapy offers unique advantages over monotherapy alone. However, free drugs, such as photosensitizers and chemotherapeutic agents, lack tumor-targeted accumulation and can be easily eliminated from the body. Moreover, most of the PTT drugs are hydrophobic and their organic solvents have in vivo toxicity, thereby limiting their potential in clinical translation...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29111267/process-optimization-and-in-vivo-performance-of-docetaxel-loaded-phbv-tpgs-therapeutic-vesicles-a-synergistic-approach
#2
Harsh Vardhan, Pooja Mittal, Sandeep Kumar Reddy Adena, Mansi Upadhyay, Sarita Kumari Yadav, Brahmeshwar Mishra
This research was motivated due to substantial requirement of improved treatment for breast cancer which accounts for over 0.52 million deaths annually worldwide. Utilizing nanoparticles carrying active medicaments as targeted delivery carrier is emerging as a promising approach. For a drug to be clinically effective, it needs to be suitably protected in the biological fluid till it is delivered to the targeted site. Keeping above in mind, we prepared and optimized polymeric nanoparticles by polyhydroxybutyrate-co-hydroxyvalerate (PHBV) a biodegradable polymer utilizing modified emulsification solvent evaporation method...
October 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29109274/near-infrared-remotely-triggered-drug-release-strategies-for-cancer-treatment
#3
Amanda M Goodman, Oara Neumann, Kamilla Nørregaard, Luke Henderson, Mi-Ran Choi, Susan E Clare, Naomi J Halas
Remotely controlled, localized drug delivery is highly desirable for potentially minimizing the systemic toxicity induced by the administration of typically hydrophobic chemotherapy drugs by conventional means. Nanoparticle-based drug delivery systems provide a highly promising approach for localized drug delivery, and are an emerging field of interest in cancer treatment. Here, we demonstrate near-IR light-triggered release of two drug molecules from both DNA-based and protein-based hosts that have been conjugated to near-infrared-absorbing Au nanoshells (SiO2 core, Au shell), each forming a light-responsive drug delivery complex...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29066894/poly-d-l-lactic-glycolic-acid-star-glucose-nanoparticles-for-glucose-transporter-and-hypoglycemia-mediated-tumor-targeting
#4
Ju-Hwan Park, Hyun-Jong Cho, Dae-Duk Kim
Poly((D,L)lactic-glycolic)acid-star glucose (PLGA-Glc) polymer-based nanoparticles (NPs) were fabricated for tumor-targeted delivery of docetaxel (DCT). NPs with an approximate mean diameter of 241 nm, narrow size distribution, negative zeta potential, and spherical shape were prepared. A sustained drug release pattern from the developed NPs was observed for 13 days. Moreover, drug release from PLGA-Glc NPs at acidic pH (endocytic compartments and tumor regions) was significantly improved compared with that observed at physiological pH (normal tissues and organs)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29058874/multibranched-gold-nanoparticles-with-intrinsic-lat-1-targeting-capabilities-for-selective-photothermal-therapy-of-breast-cancer
#5
Zhan Yuin Ong, Shu Chen, Elham Nabavi, Anna Regoutz, David J Payne, Daniel S Elson, David T Dexter, Iain E Dunlop, Alexandra E Porter
Because of the critical role of the large neutral amino acid transporter-1 (LAT-1) in promoting tumor growth and proliferation, it is fast emerging as a highly attractive biomarker for the imaging and treatment of human malignancies, including breast cancer. While multibranched gold nanoparticles (AuNPs) have emerged as a promising modality in the photothermal therapy (PTT) of cancers, some of the key challenges limiting their clinical translation lie in the need to develop reproducible and cost-effective synthetic methods as well as the selective accumulation of sufficient AuNPs at tumor sites...
November 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29033568/in-vivo-evaluation-of-cetuximab-conjugated-poly-%C3%AE-glutamic-acid-docetaxel-nanomedicines-in-egfr-overexpressing-gastric-cancer-xenografts
#6
Maya Sreeranganathan, Saji Uthaman, Bruno Sarmento, Chethampadi Gopi Mohan, In-Kyu Park, Rangasamy Jayakumar
Epidermal growth factor receptor (EGFR), upregulated in gastric cancer patients, is an oncogene of interest in the development of targeted cancer nanomedicines. This study demonstrates in silico modeling of monoclonal antibody cetuximab (CET MAb)-conjugated docetaxel (DOCT)-loaded poly(γ-glutamic acid) (γ-PGA) nanoparticles (Nps) and evaluates the in vitro/in vivo effects on EGFR-overexpressing gastric cancer cells (MKN-28). Nontargeted DOCT-γ-PGA Nps (NT Nps: 110±40 nm) and targeted CET MAb-DOCT-γ-PGA Nps (T Nps: 200±20 nm) were prepared using ionic gelation followed by 1-Ethyl-3-(3-dimethyl aminopropyl)carbodiimide-N-Hydoxysuccinimide (EDC-NSH) chemistry...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28965854/cabazitaxel-conjugated-nanoparticles-for-docetaxel-resistant-and-bone-metastatic-prostate-cancer
#7
Bryan Hoang, Mark J Ernsting, Wei-Hsin Sophia Tang, Joseph Bteich, Elijus Undzys, Taira Kiyota, Shyh-Dar Li
Effective treatment of metastatic castration resistant prostate cancer (mCRPC) remains an unmet challenge. Cabazitaxel (CBZ) is approved for mCRPC after docetaxel (DTX) failure, but the improvement in survival is only moderate (∼2 months) and patients suffer from significant side effects. Here, we report the development of a polymer based delivery system for CBZ to improve its safety and efficacy against DTX-resistant mCRPC. CBZ was conjugated to a carboxymethylcellulose-based polymer (Cellax-CBZ), which self-assembled into ∼100 nm particles in saline and exhibited sustained drug release in serum at 10%/day...
September 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28950729/self-delivering-prodrug-nanoassemblies-fabricated-by-disulfide-bond-bridged-oleate-prodrug-of-docetaxel-for-breast-cancer-therapy
#8
Shenwu Zhang, Jibin Guan, Mengchi Sun, Dong Zhang, Haotian Zhang, Bingjun Sun, Weiling Guo, Bin Lin, Yongjun Wang, Zhonggui He, Cong Luo, Jin Sun
Breast cancer leads to high mortality of women in the world. Docetaxel (DTX) has been widely applied as one of the first-line chemotherapeutic drugs for breast cancer therapy. However, the clinical outcome of DTX is far from satisfaction due to its poor drug delivery efficiency. Herein, a novel disulfide bond bridged oleate prodrug of DTX was designed and synthesized to construct self-delivering prodrug-based nanosystem for improved anticancer efficacy of DTX. The uniquely engineered prodrug-nanoassemblies showed redox-responsive drug release, increased cellular uptake and comparable cytotoxicity against 4T1 breast cancer cells when compared with free DTX...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28948910/ph-sensitive-polymeric-nanoparticles-fabricated-by-dispersion-polymerization-for-the-delivery-of-bioactive-agents
#9
Reema Puri, Solomon A Berhe, Emmanuel O Akala
BACKGROUND: Development of pH-responsive nanoparticles capable of rapid degradation in the acidic environments in the endosomes and lysosomes of tumor tissues but relatively more stable in the physiological pH (pH 7.4) is desirable. OBJECTIVE: To show that the number of methoxy groups on the benzene ring of benzaldehyde bisacrylate acetal crosslinkers should affect the rate of hydrolysis of the crosslinkers and in vitro availability of the drug loaded into the nanoparticles...
2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28948907/pharmacokinetic-consequences-of-plga-nanoparticles-in-docetaxel-drug-delivery
#10
Pedram Rafiei, Azita Haddadi
BACKGROUND: Cancer chemotherapy is accompanied with administration of highly potent cytotoxic agents in doses that can result in non-specific drug toxicity and side effects. Chemotherapeutic agents possess limitations such as lack of water solubility, high volume of distribution, poor bioavailability, narrow therapeutic indices, multi-drug resistance, etc. that raise serious matters of concern regarding drug's pharmaceutical and clinical aspects. However, application of nanoparticles in delivery of anti-cancer agents has been a popular approach to address these concerns...
2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28919747/ge11-peptide-conjugated-nanoliposomes-to-enhance-the-combinational-therapeutic-efficacy-of-docetaxel-and-sirna-in-laryngeal-cancers
#11
Wei-Wei Xu, Da-Yu Liu, Ying-Chun Cao, Xiang-Yun Wang
In this study, dual therapeutic-loaded GE11 peptide-conjugated liposomes were developed and applied to enhance therapeutic efficacies of standard-of-care regimens for the treatment of laryngeal cancer. The therapeutic strategy used here was a combination treatment with the chemotherapeutic docetaxel (DTX) and siRNA against the ABCG2 gene that regulates multidrug resistance in many tumor types. Liposome-encapsulated DTX/ABCG2-siRNA molecules were targeted to recognize tumor cells of squamous morphology by conjugation to the EGFR-targeting ligand, GE11...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28916966/evaluation-of-in-vitro-efficacy-of-docetaxel-loaded-calcium-carbonate-aragonite-nanoparticles-dtx-caco3np-on-4t1-mouse-breast-cancer-cell-line
#12
Nahidah Ibrahim Hammadi, Yusuf Abba, Mohd Noor Mohd Hezmee, Intan Shameha Abdul Razak, Aminu Umar Kura, Zuki Abu Bakar Zakaria
Cockle shell-derived calcium carbonate nanoparticles have shown promising potentials as slow drug-releasing compounds in cancer chemotherapy. In this study, we evaluated the in vitro efficacy of docetaxel (DTX)-loaded CaCO3NP on 4T1 cell line. This was achieved by evaluating the following: cytotoxicity using MTT assay, fluorescence imaging, apoptosis with Annexin V assay, cell cycle analysis, scanning (SEM) and transmission electron microscopy (TEM), and scratch assay. Based on the results, DTX-CaCO3NP with a DTX concentration of 0...
September 15, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28903067/carboxymethyl-chitosan-phospholipid-bilayer-capped-mesoporous-carbon-nanoparticles-with-ph-responsive-and-prolonged-release-properties-for-oral-delivery-of-the-antitumor-drug-docetaxel
#13
Yanzhuo Zhang, Wufu Zhu, Heran Zhang, Jin Han, Lihua Zhang, Qisi Lin, Fengwei Ai
In this article, a new type of carboxymethyl chitosan/phospholipid bilayer-capped mesoporous carbon nanomatrix (CCS/PL/MC) was fabricated as a potential nano-drug delivery system. In this drug delivery system, a mesoporous carbon nanomatrix (MC) acts as the support for loading drug molecules, a positively charged phospholipid (PL) layer works as the inner shell for prolonged drug release and a negatively charged carboxymethyl chitosan (CCS) layer serves as the outer shell for pH-responsive drug release. Docetaxel (DTX) was selected as a model drug...
September 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28901139/injectable-and-self-healing-thermosensitive-magnetic-hydrogel-for-asynchronous-control-release-of-doxorubicin-and-docetaxel-to-treat-triple-negative-breast-cancer
#14
Wensheng Xie, Qin Gao, Zhenhu Guo, Dan Wang, Fei Gao, Xiumei Wang, Yen Wei, Lingyun Zhao
Integration of two or more drugs into a multiagent delivery system has been considered to have profound impact on both in vitro and in vivo cancer treatment due to their efficient synergistic effect. This study presents a cheap and simple chitosan hydrogel cross-linked with telechelic difunctional poly(ethylene glycol) (DF-PEG-DF) for synthesis of an injectable and self-healing thermosensitive dual-drug-loaded magnetic hydrogel (DDMH), which contains both doxorubicin (DOX) and docetaxel (DTX) for chemotherapy and iron oxide for magnetic hyperthermia induced stimuli responsive drug release...
October 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28900598/cationic-pegylated-polycaprolactone-nanoparticles-carrying-post-operation-docetaxel-for-glioma-treatment
#15
Cem Varan, Erem Bilensoy
Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development of drug delivery systems is important to treat brain tumors and prevent tumor recurrence. The aim of this study was to develop core-shell polymeric nanoparticles with positive charge by employing a chitosan coating. Additionally, an implantable formulation for the chemotherapeutic nanoparticles was developed as a bioadhesive film to be applied at the tumor site following surgical operation for brain glioma treatment...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28891336/polyunsaturated-fatty-acid-based-targeted-nanotherapeutics-to-enhance-the-therapeutic-efficacy-of-docetaxel
#16
Thiruganesh Ramasamy, Pasupathi Sundaramoorthy, Hima Bindu Ruttala, Yongjoo Choi, Woo Hyun Shin, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Hwan Mook Kim, Chul Soon Yong, Jong Oh Kim
Since breast cancer is one of the most lethal malignancies, targeted strategies are urgently needed. In this study, we report the enhanced therapeutic efficacy of docetaxel (DTX) when combined with polyunsaturated fatty acids (PUFA) for effective treatment of multi-resistant breast cancers. Folic acid (FA)-conjugated PUFA-based lipid nanoparticles (FA-PLN/DTX) was developed. The physicochemical properties, in vitro uptake, in vitro cytotoxicity, and in vivo anticancer activity of FA-PLN/DTX were evaluated. FA-PLN/DTX could efficiently target and treat human breast tumor xenografts in vivo...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28874173/ternary-cocktail-nanoparticles-for-sequential-chemo-photodynamic-therapy
#17
Li Fan, Saisai Zhao, Qian Yang, Jiali Tan, Chaojun Song, Hong Wu
BACKGROUND: Previous clinical trials have already demonstrated that combinations of two or more drugs were more effective in the cancer treatment, especially sequential photodynamic design combing with sequential chemotherapy. In our study, we propose a ternary cocktail NP delivery system based on self-decomposable NPs, which could realize synergistic chemo-photodynamic therapy through double loading chemo-drugs and multi-level programmable PDT treatment. METHODS: PS drug methylene blue (MB) was encapsulated into the center of the NPsmall, NPbig&thin, and NPbig&thick carriers through "grown-in" loading mechanism, which was released based on the drug concentration difference of the drug release environment...
September 6, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28869892/combination-lung-cancer-chemotherapy-design-of-a-ph-sensitive-transferrin-peg-hz-lipid-conjugate-for-the-co-delivery-of-docetaxel-and-baicalin
#18
Shuang Li, Lin Wang, Na Li, Yucai Liu, Hui Su
The aim of the present study is to design a novel dual-ligand lipid based nanoparticle system. It is conducted by a specific ligand and pH sensitive lipid conjugate. Docetaxel (DTX) and baicalein (BA) are co-delivered by this system for combination lung cancer chemotherapy. Firstly, transferrin (Tf)-polyethylene glycol (PEG)-hydrazone (hz)-glyceryl monostearate (GMS), Tf-PEG-hz-GMS, was synthesized. Tf decorated DTX and BA loaded solid lipid nanoparticles (Tf-D/B-SLNs) were prepared by emulsification method...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28855208/bone-induced-expression-of-integrin-%C3%AE-3-enables-targeted-nanotherapy-of-breast-cancer-metastases
#19
Michael H Ross, Alison K Esser, Gregory C Fox, Anne H Schmieder, Xiaoxia Yang, Grace Hu, Dipanjan Pan, Xinming Su, Yalin Xu, Deborah V Novack, Thomas Walsh, Graham A Colditz, Gabriel H Lukaszewicz, Elizabeth Cordell, Joshua S Novack, James A J Fitzpatrick, David L Waning, Khalid S Mohammad, Theresa A Guise, Gregory M Lanza, Katherine N Weilbaecher
Bone metastases occur in ~70% of metastatic breast cancer patients often leading to skeletal injuries. Current treatments are mainly palliative and underscore the unmet clinical need for improved therapies. In this study, we provide preclinical evidence for an antimetastatic therapy based on targeting integrin β3 (β3) which is selectively induced on breast cancer cells in bone by the local bone microenvironment. In a preclinical model of breast cancer, β3 was strongly expressed on bone metastatic cancer cells but not primary mammary tumors or visceral metastases...
August 30, 2017: Cancer Research
https://www.readbyqxmd.com/read/28826287/docetaxel-loaded-nanostructured-lipid-carriers-functionalized-with-trastuzumab-herceptin-for-her2-positive-breast-cancer-cells
#20
Jaleh Varshosaz, Mohammad Ali Davoudi, Sara Rasoul-Amini
The aim of the present study was to prepare Herceptin targeted nanostructured lipid carriers (NLCs) of docetaxel (DTX). Herceptin was conjugated by chemical and physical methods to NLCs prepared by solvent extraction technique followed by probe sonication. Different types of fatty amines were used in construction of NLCs. The NLCs were characterized for their antibody coupling efficiency, particle size, zeta potential, polydispersity index, drug entrapment efficiency and drug release profiles. The toxicity of NLCs on MDA-MB-468 (HER2 negative receptor) and BT-474 (HER2 positive) breast cancer cell lines was evaluated by MTT assay...
August 21, 2017: Journal of Liposome Research
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