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Liposomes and antibiotics

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https://www.readbyqxmd.com/read/29670065/biophysical-investigations-elucidating-the-mechanisms-of-action-of-antimicrobial-peptides-and-their-synergism
#1
REVIEW
Arnaud Marquette, Burkhard Bechinger
Biophysical and structural investigations are presented with a focus on the membrane lipid interactions of cationic linear antibiotic peptides such as magainin, PGLa, LL37, and melittin. Observations made with these peptides are distinct as seen from data obtained with the hydrophobic peptide alamethicin. The cationic amphipathic peptides predominantly adopt membrane alignments parallel to the bilayer surface; thus the distribution of polar and non-polar side chains of the amphipathic helices mirror the environmental changes at the membrane interface...
April 18, 2018: Biomolecules
https://www.readbyqxmd.com/read/29653049/the-influence-of-cationic-phosphatidylcholine-derivative-on-monolayer-and-bilayer-artificial-bacterial-membranes
#2
Marzena Mach, Karolina Węder, Katarzyna Hąc-Wydro, Michał Flasiński, Joanna Lewandowska-Lancucka, Kinga Wójcik, Pawel Wydro
An increasing number of bacterial infections and the rise in antibiotic resistance of a number of bacteria speciesforces to search for new antibacterial compounds. The latter facts motivate the investigations presented herein and aimed at studying the influence of a cationic lipid:1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (EPOPC) on model (mono,- and bilayer) membranes. The monolayer experiments involved the analysis of the interactions of EPOPC with bacterial membrane lipids in one component and mixed systems as well as Brewster Angle Microcopy studies...
April 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29651836/near-infrared-light-activated-thermosensitive-liposomes-as-efficient-agents-for-photothermal-and-antibiotic-synergistic-therapy-of-bacterial-biofilm
#3
Yu Zhao, Xiaomei Dai, Xiaosong Wei, Yunjian Yu, Xuelei Chen, Xinge Zhang, Chaoxing Li
Biofilm is closely related to chronic infections and is difficult to eradicate. Development of effective therapy strategies to control biofilm infection is still challenging. Aiming at biofilm architecture, we designed and prepared near infrared-activated thermosensitive liposomes with photothermal and antibiotic synergistic therapy capacity to eliminate P. aeruginosa biofilm. The liposomes with positive charge and small size aided to enter the biofilm microchannels and locally released antibiotics in infection site...
April 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29601930/liposome-supported-peritoneal-dialysis-in-the-treatment-of-severe-hyperammonemia-an-investigation-on-potential-interactions
#4
Giovanna Giacalone, Simon Matoori, Valentina Agostoni, Vincent Forster, Meriam Kabbaj, Sarah Eggenschwiler, Martin Lussi, Andrea De Gottardi, Nicola Zamboni, Jean-Christophe Leroux
Peritoneal dialysis (PD) performed with transmembrane pH-gradient liposomes was reported to efficiently remove ammonia from the body, representing a promising alternative to current standard-of-care for patients with severe hepatic encephalopathy. In this study, we further characterized the properties of liposome-supported peritoneal dialysis (LSPD) by 1) assessing its in-use stability in the presence of ascitic fluids from liver-disease patients; 2) investigating its interactions with drugs that are commonly administered to acute-on-chronic liver failure patients; and 3) analyzing the in vivo extraction profile of LSPD...
March 27, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29525621/lipid-mediated-mode-of-action-of-local-anesthetics-on-lipid-pores-induced-by-polyenes-peptides-and-lipopeptides
#5
Svetlana S Efimova, Evgeny G Chulkov, Olga S Ostroumova
The effects of local anesthetics (LAs), namely, lidocaine (LDC), prilocaine (PLC), mepivacaine (MPV), bupivacaine (BPV), procaine (PC), and tetracaine (TTC), on the steady-state transmembrane conductance induced by the cis-side addition of the antifungal polyene macrolide antibiotic, nystatin (NYS), in planar lipid bilayers were studied. The addition of TTC to model membranes comprising DOPC and cholesterol (33 mol%) led to a nearly twenty-fold increase in the steady-state NYS-induced membrane conductance...
March 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29501941/design-synthesis-and-biological-evaluation-of-stable-%C3%AE-6-3-helices-discovery-of-non-hemolytic-antibacterial-peptides
#6
Damodara N Reddy, Sukrit Singh, Chris M W Ho, Janki Patel, Paul Schlesinger, Stephen Rodgers, Allan Doctor, Garland R Marshall
Gramicidin A, a topical antibiotic made from alternating L and D amino acids, is characterized by its wide central pore; upon insertion into membranes, it forms channels that disrupts ion gradients. We present helical peptidomimetics with this characteristic wide central pore that have been designed to mimic gramicidin A channels. Mimetics were designed using molecular modeling focused on oligomers of heterochiral dipeptides of proline analogs, in particular azaproline (AzPro). Molecular Dynamics simulations in water confirmed the stability of the designed helices...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29498309/temperature-sensitive-liposomal-ciprofloxacin-for-the-treatment-of-biofilm-on-infected-metal-implants-using-alternating-magnetic-fields
#7
Imalka Munaweera, Sumbul Shaikh, Danny Maples, Adane S Nigatu, Sri Nandhini Sethuraman, Ashish Ranjan, David E Greenberg, Rajiv Chopra
Implants are commonly used as a replacement for damaged tissue. Many implants, such as pacemakers, chronic electrode implants, bone screws, and prosthetic joints, are made of or contain metal. Infections are one of the difficult to treat complications associated with metal implants due to the formation of biofilm, a thick aggregate of extracellular polymeric substances (EPS) produced by the bacteria. In this study, we treated a metal prosthesis infection model using a combination of ciprofloxacin-loaded temperature-sensitive liposomes (TSL) and alternating magnetic fields (AMF)...
March 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29482319/drug-partitioning-in-micellar-media-and-its-implications-in-rational-drug-design-insights-with-streptomycin
#8
Eva Judy, Darshna Pagariya, Nand Kishore
Oral bioavailability of a drug molecule requires its effective delivery to the target site. In general, majority of synthetically developed molecular entities have high hydrophobic nature as well as low bioavailability, therefore the need for suitable delivery vehicles arises. Self-assembled structures such as micelles, niosomes, and liposomes have been used as effective delivery vehicles and studied extensively. However, the information available in literature is mostly qualitative in nature. We have quantitatively investigated the partitioning of antibiotic drug streptomycin into cationic, non-ionic and mixture of cationic and non-ionic surfactant micelles and its interaction with the transport protein serum albumin upon subsequent delivery...
February 26, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29472905/1-2-4-dichlorophenethyl-amino-3-phenoxypropan-2-ol-kills-pseudomonas-aeruginosa-through-extensive-membrane-damage
#9
Valerie Defraine, Veerle Liebens, Evelien Loos, Toon Swings, Bram Weytjens, Carolina Fierro, Kathleen Marchal, Liam Sharkey, Alex J O'Neill, Romu Corbau, Arnaud Marchand, Patrick Chaltin, Maarten Fauvart, Jan Michiels
The ever increasing multidrug-resistance of clinically important pathogens and the lack of novel antibiotics have resulted in a true antibiotic crisis where many antibiotics are no longer effective. Further complicating the treatment of bacterial infections are antibiotic-tolerant persister cells. Besides being responsible for the recalcitrant nature of chronic infections, persister cells greatly contribute to the observed antibiotic tolerance in biofilms and even facilitate the emergence of antibiotic resistance...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29460722/cutaneous-toxicity-in-a-laboratory-beagle-canis-lupus-familiaris-after-chronic-administration-of-doxorubicin-hydrochloride
#10
Kathryn A Guerriero, Steven R Wilson, Nabil E Boutagy, Chi Liu, Albert J Sinusas, Caroline J Zeiss
An adult female beagle (Canis lupus familiaris) used in a model of doxorubicin-induced cardiomyopathy presented with epithelial desquamation on the shoulders and ventrum after receiving the 8th weekly intravenous dose of the free form of doxorubicin (20 mg/m2; total accumulation, 160 mg/m2). The lesions were empirically treated with topical disinfectants and topical and systemic antibiotics. Despite treatment, the lesions progressed and ulcerated. Bacterial culture revealed Staphylococcus aureus, but trichogram, skin scraping, and fungal culture were negative for microorganisms...
February 1, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29430821/alanine-and-lysine-scans-of-the-ll-37-derived-peptide-fragment-kr-12-reveal-key-residues-for-antimicrobial-activity
#11
Sunithi Gunasekera, Taj Muhammad, Adam A Strömstedt, K Johan Rosengren, Ulf Göransson
The human host defence peptide LL-37 is a broad-spectrum antibiotic with immunomodulatory functions. Residues 18-29 in LL-37 have previously been identified as a minimal peptide (KR-12) that retains antibacterial activity with decreased cytotoxicity. In this study, we generated analogues of KR-12 by Ala and Lys scans to identify key elements for activity. These were tested against a panel of human pathogens and for membrane permeabilization on liposomes. Replacements of hydrophobic and cationic residues with Ala were detrimental for antibiotic potency...
February 11, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29391780/diminishing-the-side-effect-of-mitomycin-c-by-using-ph-sensitive-liposomes-in-vitro-characterization-and-in-vivo-pharmacokinetics
#12
Yi-Ping Fang, Pei-Yu Hu, Yaw-Bin Huang
Introduction: Mitomycin C is an anticancer antibiotic agent that has the potential for broad-spectrum use against several cancers, including mammary cancers. Because its half-life is 17 min after a 30 mg intravenous bolus administration, the suitability of mitomycin C for wide use in the clinical setting is limited. Based on tumor pathophysiology, pH-sensitive liposomes could provide better tumor-targeted effects. The aim of this study was to investigate the possibility of diminishing the side effect of mitomycin C by using pH-sensitive liposomes...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29348524/linearmycins-are-lytic-membrane-targeting-antibiotics
#13
Reed M Stubbendieck, Dakota J Brock, Jean-Philippe Pellois, Jason J Gill, Paul D Straight
The linearmycin family of polyketides was originally classified as antifungal metabolites. However, in addition to antifungal activity, we previously found that linearmycins cause cellular lysis and colony degradation of the Gram-positive bacterium Bacillus subtilis. We recently showed that Streptomyces sp. strain Mg1 incorporates linearmycins into extracellular vesicles, which are capable of lysing B. subtilis. However, the mechanism of linearmycin-induced lysis was hitherto unexplored. Therefore, we sought to determine how linearmycin-laden vesicles cause lysis...
March 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29339382/-in-vitro-susceptibility-of-neisseria-gonorrhoeae-strains-to-mupirocin-an-antibiotic-reformulated-for-parenteral-administration-in-nanoliposomes
#14
Ahuva Cern, Kristie L Connolly, Ann E Jerse, Yechezkel Barenholz
Neisseria gonorrhoeae is an urgent antibiotic-resistant threat. This study determined the MICs of mupirocin to be 0.0039 to 0.0625 μg/ml for 94 N. gonorrhoeae strains. Cross-resistance with other antibiotics was not detected. Mupirocin, which is currently limited to topical administration, demonstrated activity by injection when delivered in nanoliposomes. The nanoliposomal formulation of mupirocin is a potential treatment for drug-resistant N. gonorrhoeae .
April 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29323910/direct-synthesis-of-prussian-blue-nanoparticles-in-liposomes-incorporating-natural-ion-channels-for-cs-adsorption-and-particle-size-control
#15
Tomomi Koshiyama, Motoki Tanaka, Masayuki Honjo, Yumi Fukunaga, Tomoya Okamura, Masaaki Ohba
Coordination polymer (CP) nanoparticles (NPs) formed by a self-assembly of organic ligands and metal ions are one of the attractive materials for molecular capture and deliver/release in aqueous media. Control of particle size and prevention of aggregation among CP NPs are important factors for improving their adsorption capability in water. We demonstrate here the potential of a liposome incorporating an antibiotic ion channel as a vessel for synthesizing Prussian blue (PB) NPs, being a typical CP. In the formation of PB NPs within liposomes, the influx rate of Fe2+ ions into liposome encapsulated [Fe(CN)6 ]3- through channels was fundamental for the change of NPs' sizes...
January 30, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29311198/fungal-peritonitis-caused-by-rhodotorula-mucilaginosa-in-a-capd-patient-treated-with-liposomal-amphotericin-b-a-case-report-and-literature-review
#16
Frédéric Franconieri, Julie Bonhomme, Aline Doriot, Cécile Bonnamy, Maxence Ficheux, Thierry Lobbedez, Clémence Béchade
Rhodotorula mucilaginosa is a ubiquitous yeast that may cause serious peritoneal dialysis (PD) infections. A 70-year-old man receiving continuous ambulatory peritoneal dialysis (CAPD) for 6 months presented with a PD infection caused by Rhodotorula mucilaginosa The patient was treated with intravenous liposomal amphotericin B. His peritoneal catheter was simultaneously removed and reinserted. To date, only 10 cases of Rhodotorula CAPD infections have been reported. Catheters, corticoids, cancer, and previous antibiotic therapy were the main risk factors for these infections...
January 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29305156/novel-lipids-with-three-c18-fatty-acid-chains-and-an-amino-acid-head-group-for-ph-responsive-and-sustained-antibiotic-delivery
#17
Mahantesh Jadhav, Rahul S Kalhapure, Sanjeev Rambharose, Chunderika Mocktar, Sanil Singh, Tetsuya Kodama, Thirumala Govender
The acidic environment at bacterial infection sites is a potential external stimulus for targeted antibiotic delivery. This paper reports new biocompatible pH-sensitive lipids (PSLs) with three hydrocarbon tails, and a head group with a secondary amine and carboxylate function for site-specific nano delivery of vancomycin (VCM). PSLs formed stable liposomes with mean vesicle diameters and polydispersity indices between 99.38 ± 6.59 nm to 105.60 ± 5.38 nm and 0.161 ± 0.003 to 0.219 ± 0...
January 2, 2018: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29278945/elastin-like-polypeptide-incorporated-thermally-sensitive-liposome-improve-antibiotic-therapy-against-musculoskeletal-bacterial-pathogens
#18
Adane S Nigatu, Harshini Ashar, Sri Nandhini Sethuraman, Rachel Wardlow, Danny Maples, Jerry Malayer, Ashish Ranjan
Musculoskeletal infections caused by bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa in children and adults can lead to adverse outcomes including a need for extensive surgical debridement and limb amputation. To enable targeted antimicrobial release in infected tissues, the objective of this study was to design and investigate novel elastin-like polypeptide (ELP)-based thermally sensitive liposomes in vitro. ELP biopolymers can change their phase behaviour at higher temperatures. We hypothesised that ELP-TSL will improve therapeutic efficacy by releasing antimicrobial payloads locally at higher temperatures (≥39 °C)...
March 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29249044/endogenous-fusarium-endophthalmitis-during-treatment-for-acute-myeloid-leukemia-successfully-treated-with-25-gauge-vitrectomy-and-antifungal-medications
#19
Masaaki Yoshida, Naoki Kiyota, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Toyokawa, Shigehiro Hagiwara, Koichi Makimura, Naomi Sato, Shinji Taniuchi, Toru Nakazawa
Endogenous fungal endophthalmitis (EFE) caused by disseminated fusariosis is a rare condition that generally has a poor outcome, even with intensive therapy. Here, we describe a case in which this type of EFE was diagnosed with vitreous sampling and was successfully treated with 25-gauge vitrectomy and antifungals, including liposomal amphotericin B and voriconazole. A 16-year-old male patient undergoing treatment for acute myeloid leukemia complained of eye pain and blurred vision in his right eye. Treatment was initiated for a vitreous opacity, possibly associated with herpetic retinitis, but the patient worsened and he was referred to us...
April 2018: Mycopathologia
https://www.readbyqxmd.com/read/29248479/nanomaterials-and-molecular-transporters-to-overcome-the-bacterial-envelope-barrier-towards-advanced-delivery-of-antibiotics
#20
Rita S Santos, Céu Figueiredo, Nuno F Azevedo, Kevin Braeckmans, Stefaan C De Smedt
With the dramatic consequences of bacterial resistance to antibiotics, nanomaterials and molecular transporters have started to be investigated as alternative antibacterials or anti-infective carrier systems to improve the internalization of bactericidal drugs. However, the capability of nanomaterials/molecular transporters to overcome the bacterial cell envelope is poorly understood. It is critical to consider the sophisticated architecture of bacterial envelopes and reflect how nanomaterials/molecular transporters can interact with these envelopes, being the major aim of this review...
December 14, 2017: Advanced Drug Delivery Reviews
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