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Liposomes and antibiotics

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https://www.readbyqxmd.com/read/29902693/bioanalysis-of-free-and-liposomal-amphotericin-b-in-rat-plasma-using-solid-phase-extraction-and-protein-precipitation-followed-by-lc-ms-ms
#1
Chong Su, Hong Yang, Hui Sun, John Paul Fawcett, Dong Sun, Jingkai Gu
Amphotericin B (AMB) is a polyene macrolide antibiotic used for treating invasive fungal infections. Liposomal AMB (L-AMB) is a lipid dosage form which reduces the side effects and toxicity of the drug. The quantitation of free AMB (F-AMB) and L-AMB in vivo is important to monitor quality control of the liposomal formulation and to ensure its safety during clinical use. In this study, an original strategy was developed to separately determine F-AMB and L-AMB in rat plasma using LC-MS/MS. F-AMB was analyzed after separation by solid phase extraction, total AMB (T-AMB) was determined after protein precipitation and L-AMB was determined by difference...
June 8, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29885365/impact-of-curcumin-liposomes-with-anti-quorum-sensing-properties-against-foodborne-pathogens-aeromonas-hydrophila-and-serratia-grimesii
#2
Ting Ding, Tingting Li, Jianrong Li
Quorum sensing (QS) is a signal sensing system by which bacteria monitor the density of their population, thus, targeting to QS system may be an alternative approach to control diverse cellular processes including the microbial contamination and the virulence of human and plant pathogens as bacteria have been evolving resistance to antibiotics. In this study, curcumin liposomes were prepared by film dispersion method to increase its bioavailability against QS systems of food-borne epathogenic bacteria, i.e...
June 6, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29867826/amikacin-liposome-inhalation-suspension-alis-penetrates-non-tuberculous-mycobacterial-biofilms-and-enhances-amikacin-uptake-into-macrophages
#3
Jimin Zhang, Franziska Leifer, Sasha Rose, Dung Yu Chun, Jill Thaisz, Tracey Herr, Mary Nashed, Jayanthi Joseph, Walter R Perkins, Keith DiPetrillo
Non-tuberculous mycobacteria (NTM) cause pulmonary infections in patients with structural lung damage, impaired immunity, or other risk factors. Delivering antibiotics to the sites of these infections is a major hurdle of therapy because pulmonary NTM infections can persist in biofilms or as intracellular infections within macrophages. Inhaled treatments can improve antibiotic delivery into the lungs, but efficient nebulization delivery, distribution throughout the lungs, and penetration into biofilms and macrophages are considerable challenges for this approach...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29850694/polymer-augmented-liposomes-enhancing-antibiotic-delivery-against-intracellular-infections
#4
Fang-Yi Su, Jasmin Chen, Hye-Nam Son, Abby M Kelly, Anthony J Convertine, T Eoin West, Shawn J Skerrett, Daniel M Ratner, Patrick S Stayton
Pulmonary intracellular infections, such as tuberculosis, anthrax, and tularemia, have remained a significant challenge to conventional antibiotic therapy. Ineffective antibiotic treatment of these infections can lead not only to undesired side effects, but also to the emergence of antibiotic resistance. Aminoglycosides (e.g., streptomycin) have long been part of the therapeutic regiment for many pulmonary intracellular infections. Their bioavailability for intracellular bacterial pools, however, is limited by poor membrane permeability and rapid elimination...
May 31, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29807522/current-state-of-nanomedicines-in-the-treatment-of-topical-infectious-disorders
#5
Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber, Om Prakash Katare
BACKGROUND: Topical infections, involving a number of diseases such as impetigo, eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the many challenges to health which stand out for their profound impact on human species. The treatment of topical infections has always been a difficult proposition because of the lack of efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery. The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa undermine the need of development of new delivery systems to enhance the therapeutic efficacy of existing topical anti-infectives...
May 28, 2018: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29799150/action-of-antimicrobial-peptides-and-their-prodrugs-on-model-and-biological-membranes
#6
Éanna Forde, Ghady Shafiy, Deirdre Fitzgerald-Hughes, Adam A Strömstedt, Marc Devocelle
Antimicrobial peptides (AMPs) are promising broad-spectrum antibiotic candidates in the wake of multi-drug resistant pathogens. Their clinical use still requires a solution based on lead optimisation and/or formulation to overcome certain limitations, such as unwanted cytotoxicity. A prodrug approach could overcome this safety barrier and can be achieved through reversible reduction or neutralisation of the AMPs' net cationic charge. By prodrug activation through pathogen associated enzymes, this approach could increase the therapeutic index of membrane active peptides...
May 24, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29790304/reducing-bacterial-infections-and-biofilm-formation-using-nanoparticles-and-nanostructured-antibacterial-surfaces
#7
REVIEW
Gujie Mi, Di Shi, Mian Wang, Thomas J Webster
With the rapid spreading of resistance among common bacterial pathogens, bacterial infections, especially antibiotic-resistant bacterial infections, have drawn much attention worldwide. In light of this, nanoparticles, including metal and metal oxide nanoparticles, liposomes, polymersomes, and solid lipid nanoparticles, have been increasingly exploited as both efficient antimicrobials themselves or as delivery platforms to enhance the effectiveness of existing antibiotics. In addition to the emergence of widespread antibiotic resistance, of equal concern are implantable device-associated infections, which result from bacterial adhesion and subsequent biofilm formation at the site of implantation...
May 22, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29773788/immunogene-therapy-with-fusogenic-nanoparticles-modulates-macrophage-response-to-staphylococcus-aureus
#8
Byungji Kim, Hong-Bo Pang, Jinyoung Kang, Ji-Ho Park, Erkki Ruoslahti, Michael J Sailor
The incidence of adverse effects and pathogen resistance encountered with small molecule antibiotics is increasing. As such, there is mounting focus on immunogene therapy to augment the immune system's response to infection and accelerate healing. A major obstacle to in vivo gene delivery is that the primary uptake pathway, cellular endocytosis, results in extracellular excretion and lysosomal degradation of genetic material. Here we show a nanosystem that bypasses endocytosis and achieves potent gene knockdown efficacy...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29751064/mechanistic-and-phenotypic-studies-of-bicarinalin-bp100-and-colistin-action-on-acinetobacter-baumannii
#9
Marcus G Eales, Enrico Ferrari, Alan D Goddard, Lorna Lancaster, Peter Sanderson, Clare Miller
Acinetobacter baumannii has been identified by the WHO as a high priority pathogen. It can be resistant to multiple antibiotics and colistin sulphate is often used as a last-resort treatment. However, the potentially severe side-effects of colistin are well documented and this study compared the bactericidal and anti-biofilm activity of two synthetic nature-inspired antimicrobial peptides, bicarinalin and BP100, with colistin. The minimum bactericidal concentration (MBC) against planktonic A. baumannii was approximately 0...
May 8, 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29727963/bioaccumulation-and-tissue-distribution-of-antibiotics-in-wild-marine-fish-from-laizhou-bay-north-china
#10
Sisi Liu, Tadiyose-Girma Bekele, Hongxia Zhao, Xiyun Cai, Jingwen Chen
Information about bioaccumulation and tissue distribution of antibiotics in wild marine fish is still limited. In the present study, tissue levels, bioaccumulation and distribution patterns of 9 sulfonamide (SA), trimethoprim (TMP), 5 fluoroquinolone (FQ), and 4 macrolide (ML) antibiotics were investigated in gill, muscle, kidney, and liver tissues of seven wild fish species collected from Laizhou Bay, North China in 2016. All the 19 antibiotics were detected in these fish tissues with the total concentrations ranging from 22ng/g dry weight (dw) to 500ng/g dw...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29670065/biophysical-investigations-elucidating-the-mechanisms-of-action-of-antimicrobial-peptides-and-their-synergism
#11
REVIEW
Arnaud Marquette, Burkhard Bechinger
Biophysical and structural investigations are presented with a focus on the membrane lipid interactions of cationic linear antibiotic peptides such as magainin, PGLa, LL37, and melittin. Observations made with these peptides are distinct as seen from data obtained with the hydrophobic peptide alamethicin. The cationic amphipathic peptides predominantly adopt membrane alignments parallel to the bilayer surface; thus the distribution of polar and non-polar side chains of the amphipathic helices mirror the environmental changes at the membrane interface...
April 18, 2018: Biomolecules
https://www.readbyqxmd.com/read/29653049/influence-of-cationic-phosphatidylcholine-derivative-on-monolayer-and-bilayer-artificial-bacterial-membranes
#12
Marzena Mach, Karolina Węder, Katarzyna Hąc-Wydro, Michał Flasiński, Joanna Lewandowska-Łańcucka, Kinga Wójcik, Paweł Wydro
An increasing number of bacterial infections and the rise in antibiotic resistance of a number of bacteria species forces one to search for new antibacterial compounds. The latter facts motivate the investigations presented herein and are aimed at studying the influence of a cationic lipid, 1-palmitoyl-2-oleoyl- sn-glycero-3-ethylphosphocholine (EPOPC), on model (mono- and bilayer) membranes. The monolayer experiments involved the analysis of the interactions of EPOPC with bacterial membrane lipids in one component and mixed systems as well as Brewster angle microcopy studies...
May 1, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29651836/near-infrared-light-activated-thermosensitive-liposomes-as-efficient-agents-for-photothermal-and-antibiotic-synergistic-therapy-of-bacterial-biofilm
#13
Yu Zhao, Xiaomei Dai, Xiaosong Wei, Yunjian Yu, Xuelei Chen, Xinge Zhang, Chaoxing Li
Biofilm is closely related to chronic infections and is difficult to eradicate. Development of effective therapy strategies to control biofilm infection is still challenging. Aiming at biofilm architecture, we designed and prepared near-infrared-activated thermosensitive liposomes with photothermal and antibiotic synergistic therapy capacity to eliminate Pseudomonas aeruginosa biofilm. The liposomes with positive charge and small size aided to enter the biofilm microchannels and locally released antibiotics in infection site...
May 2, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29601930/liposome-supported-peritoneal-dialysis-in-the-treatment-of-severe-hyperammonemia-an-investigation-on-potential-interactions
#14
Giovanna Giacalone, Simon Matoori, Valentina Agostoni, Vincent Forster, Meriam Kabbaj, Sarah Eggenschwiler, Martin Lussi, Andrea De Gottardi, Nicola Zamboni, Jean-Christophe Leroux
Peritoneal dialysis (PD) performed with transmembrane pH-gradient liposomes was reported to efficiently remove ammonia from the body, representing a promising alternative to current standard-of-care for patients with severe hepatic encephalopathy. In this study, we further characterized the properties of liposome-supported peritoneal dialysis (LSPD) by 1) assessing its in-use stability in the presence of ascitic fluids from liver-disease patients; 2) investigating its interactions with drugs that are commonly administered to acute-on-chronic liver failure patients; and 3) analyzing the in vivo extraction profile of LSPD...
May 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29525621/lipid-mediated-mode-of-action-of-local-anesthetics-on-lipid-pores-induced-by-polyenes-peptides-and-lipopeptides
#15
Svetlana S Efimova, Evgeny G Chulkov, Olga S Ostroumova
The effects of local anesthetics (LAs), namely, lidocaine (LDC), prilocaine (PLC), mepivacaine (MPV), bupivacaine (BPV), procaine (PC), and tetracaine (TTC), on the steady-state transmembrane conductance induced by the cis-side addition of the antifungal polyene macrolide antibiotic, nystatin (NYS), in planar lipid bilayers were studied. The addition of TTC to model membranes comprising DOPC and cholesterol (33 mol%) led to a nearly twenty-fold increase in the steady-state NYS-induced membrane conductance...
June 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29501941/design-synthesis-and-biological-evaluation-of-stable-%C3%AE-6-3-helices-discovery-of-non-hemolytic-antibacterial-peptides
#16
Damodara N Reddy, Sukrit Singh, Chris M W Ho, Janki Patel, Paul Schlesinger, Stephen Rodgers, Allan Doctor, Garland R Marshall
Gramicidin A, a topical antibiotic made from alternating L and D amino acids, is characterized by its wide central pore; upon insertion into membranes, it forms channels that disrupts ion gradients. We present helical peptidomimetics with this characteristic wide central pore that have been designed to mimic gramicidin A channels. Mimetics were designed using molecular modeling focused on oligomers of heterochiral dipeptides of proline analogs, in particular azaproline (AzPro). Molecular Dynamics simulations in water confirmed the stability of the designed helices...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29498309/temperature-sensitive-liposomal-ciprofloxacin-for-the-treatment-of-biofilm-on-infected-metal-implants-using-alternating-magnetic-fields
#17
Imalka Munaweera, Sumbul Shaikh, Danny Maples, Adane S Nigatu, Sri Nandhini Sethuraman, Ashish Ranjan, David E Greenberg, Rajiv Chopra
Implants are commonly used as a replacement for damaged tissue. Many implants, such as pacemakers, chronic electrode implants, bone screws, and prosthetic joints, are made of or contain metal. Infections are one of the difficult to treat complications associated with metal implants due to the formation of biofilm, a thick aggregate of extracellular polymeric substances (EPS) produced by the bacteria. In this study, we treated a metal prosthesis infection model using a combination of ciprofloxacin-loaded temperature-sensitive liposomes (TSL) and alternating magnetic fields (AMF)...
March 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29482319/drug-partitioning-in-micellar-media-and-its-implications-in-rational-drug-design-insights-with-streptomycin
#18
Eva Judy, Darshna Pagariya, Nand Kishore
Oral bioavailability of a drug molecule requires its effective delivery to the target site. In general, majority of synthetically developed molecular entities have high hydrophobic nature as well as low bioavailability, therefore the need for suitable delivery vehicles arises. Self-assembled structures such as micelles, niosomes, and liposomes have been used as effective delivery vehicles and studied extensively. However, the information available in literature is mostly qualitative in nature. We have quantitatively investigated the partitioning of antibiotic drug streptomycin into cationic, nonionic, and a mixture of cationic and nonionic surfactant micelles and its interaction with the transport protein serum albumin upon subsequent delivery...
March 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29472905/1-2-4-dichlorophenethyl-amino-3-phenoxypropan-2-ol-kills-pseudomonas-aeruginosa-through-extensive-membrane-damage
#19
Valerie Defraine, Veerle Liebens, Evelien Loos, Toon Swings, Bram Weytjens, Carolina Fierro, Kathleen Marchal, Liam Sharkey, Alex J O'Neill, Romu Corbau, Arnaud Marchand, Patrick Chaltin, Maarten Fauvart, Jan Michiels
The ever increasing multidrug-resistance of clinically important pathogens and the lack of novel antibiotics have resulted in a true antibiotic crisis where many antibiotics are no longer effective. Further complicating the treatment of bacterial infections are antibiotic-tolerant persister cells. Besides being responsible for the recalcitrant nature of chronic infections, persister cells greatly contribute to the observed antibiotic tolerance in biofilms and even facilitate the emergence of antibiotic resistance...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29460722/cutaneous-toxicity-in-a-laboratory-beagle-canis-lupus-familiaris-after-chronic-administration-of-doxorubicin-hydrochloride
#20
Kathryn A Guerriero, Steven R Wilson, Nabil E Boutagy, Chi Liu, Albert J Sinusas, Caroline J Zeiss
An adult female beagle (Canis lupus familiaris) used in a model of doxorubicin-induced cardiomyopathy presented with epithelial desquamation on the shoulders and ventrum after receiving the 8th weekly intravenous dose of the free form of doxorubicin (20 mg/m2; total accumulation, 160 mg/m2). The lesions were empirically treated with topical disinfectants and topical and systemic antibiotics. Despite treatment, the lesions progressed and ulcerated. Bacterial culture revealed Staphylococcus aureus, but trichogram, skin scraping, and fungal culture were negative for microorganisms...
February 1, 2018: Comparative Medicine
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