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https://www.readbyqxmd.com/read/29774075/plectin-targeted-liposomes-enhance-the-therapeutic-efficacy-of-a-parp-inhibitor-in-the-treatment-of-ovarian-cancer
#1
Siva Sai Krishna Dasa, Galina Diakova, Ryo Suzuki, Anne M Mills, Michael F Gutknecht, Alexander L Klibanov, Jill K Slack-Davis, Kimberly A Kelly
Advances in genomics and proteomics drive precision medicine by providing actionable genetic alterations and molecularly targeted therapies, respectively. While genomic analysis and medicinal chemistry have advanced patient stratification with treatments tailored to the genetic profile of a patient's tumor, proteomic targeting has the potential to enhance the therapeutic index of drugs like poly(ADP-ribose) polymerase (PARP) inhibitors. PARP inhibitors in breast and ovarian cancer patients with BRCA1/2 mutations have shown promise...
2018: Theranostics
https://www.readbyqxmd.com/read/29771417/lncrna-fer1l4-suppressed-cancer-cell-growth-and-invasion-in-esophageal-squamous-cell-carcinoma
#2
W Ma, C-Q Zhang, H-L Li, J Gu, G-Y Miao, H-Y Cai, J-K Wang, L-J Zhang, Y-M Song, Y-H Tian, Y-H Song
OBJECTIVE: To investigate the regulatory effect of long non-coding ribonucleic acid (lncRNA) FER1L4 on biological behaviors of esophageal squamous cell carcinoma (ESCC) cells, such as proliferation and invasion. PATIENTS AND METHODS: The expressions of FER1L4 were detected in 42 pairs of ESCC tissues and corresponding para-carcinoma tissues and 5 kinds of ESCC cell lines via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Polyethyleneimine (PEI) and liposomes were used for FER1L4 expression or interference elimination assays, respectively...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29770869/curcumin-inhibits-autocrine-growth-hormone-mediated-invasion-and-metastasis-by-targeting-nf-%C3%AE%C2%BAb-signaling-and-polyamine-metabolism-in-breast-cancer-cells
#3
Ajda Coker-Gurkan, Merve Celik, Merve Ugur, Elif-Damla Arisan, Pinar Obakan-Yerlikaya, Zeynep Begum Durdu, Narcin Palavan-Unsal
Curcumin is assumed to be a plant-derived therapeutic drug that triggers apoptotic cell death in vitro and in vivo by affecting different molecular targets such as NF-κB. Phase I/II trial of curcumin alone or with chemotherapeutic drugs has been accomplished in pancreatic, colon, prostate and breast cancer cases. Recently, autocrine growth hormone (GH) signaling-induced cell growth, metastasis and drug resistance have been demonstrated in breast cancer. In this study, our aim was to investigate the potential therapeutic effect of curcumin by evaluating the molecular machinery of curcumin-triggered apoptotic cell death via focusing on NF-κB signaling and polyamine (PA) metabolism in autocrine GH-expressing MCF-7, MDA-MB-453 and MDA-MB-231 breast cancer cells...
May 16, 2018: Amino Acids
https://www.readbyqxmd.com/read/29768226/comparison-of-the-effects-of-three-kinds-of-igys-normal-nanoliposomal-and-nanoparticle-conjugated-which-are-produced-against-the-small-domains-of-dr5-protein-on-cancer-cells
#4
Shaghaegh Amirijavid, Maliheh Entezari
Cancer treatment with several kinds of drugs, especially targets the apoptotic pathways nowadays. TNF-related apoptosis-inducing ligand (TRAIL) as one of the important members of death receptors, significantly trigger induction of apoptosis in cancer cells. Three conserved domains of Death receptor (DR5) protein extracellular domain, which are fortified cysteine, were chosen and chemically synthesised. Hens were immunised with nano-liposomal peptides, and as a result the purified Immunoglobulin (IgYs) remarkably killed the cancerous MCF7 cells...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29767242/in-vivo-antitumor-activity-of-liposome%C3%A2-plasmid-dna-encoding-mutant-survivin%C3%A2-t34a-in-cervical-cancer
#5
Fang Qiu, Xia Zhao
The aim of the present study was to investigate the influence of liposome‑plasmid encoding mutant survivin‑T34A (PST34A) on tumor growth in cervical cancer in vivo. Liposome‑plasmid DNA encoding mutant survivin‑T34A was constructed and administered via an intraperitoneal injection in mice inoculated with cervical cancer cells. Following the establishment of the tumor model, the animals were randomly divided into four groups: i) The normal saline group (NS; 100 µl sterile saline once/3 days for 15 days); ii) the 1,2‑dioleoyl‑3‑trimethylammonium‑propane (DOTAP) control (100 µg DOTAP once/3 days for 15 days); iii) the plasmid PST34A (10 µg PST34A once/3 days for 15 days); and iv) the PST34A+DOTAP (10 µg PST34A+100 µg DOTAP once/3 days for 15 days)...
May 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29757876/a-randomized-trial-of-prophylactic-extended-carboplatin-infusion-to-reduce-hypersensitivity-reactions-in-recurrent-ovarian-cancer
#6
Katherine LaVigne, David M Hyman, Qin C Zhou, Alexia Iasonos, William P Tew, Carol Aghajanian, Vicky Makker, Martee L Hensley, Jason Konner, Rachel N Grisham, Nicholas Cangemi, Krysten Soldan, David R Spriggs, Paul J Sabbatini, Roisin E OʼCearbhaill
OBJECTIVE: Hypersensitivity with repeated exposure to platinum agents is common and can preclude continued treatment, even in patients with disease that remains platinum sensitive. We sought to compare the effects of prophylactic, extended carboplatin infusion versus standard infusion on the rate of carboplatin hypersensitivity reactions (HSRs) in women with recurrent ovarian cancer. METHODS: This was a single-institution, randomized, nonblinded trial comparing a graded, 3-hour extended infusion of carboplatin with a standard 30-minute infusion in patients with recurrent ovarian cancer who were enrolled from January 2011 to April 2015...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29755309/targeted-delivery-of-crispr-cas9-mediated-cancer-gene-therapy-via-liposome-templated-hydrogel-nanoparticles
#7
Zeming Chen, Fuyao Liu, Yanke Chen, Jun Liu, Xiaoying Wang, Ann T Chen, Gang Deng, Hongyi Zhang, Jie Liu, Zhangyong Hong, Jiangbing Zhou
Due to its simplicity, versatility, and high efficiency, the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 technology has emerged as one of the most promising approaches for treatment of a variety of genetic diseases, including human cancers. However, further translation of CRISPR/Cas9 for cancer gene therapy requires development of safe approaches for efficient, highly specific delivery of both Cas9 and single guide RNA to tumors. Here, novel core-shell nanostructure, liposome-templated hydrogel nanoparticles (LHNPs) that are optimized for efficient codelivery of Cas9 protein and nucleic acids is reported...
December 8, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29752104/antibody-fragment-conjugated-gemcitabine-and-paclitaxel-based-liposome-for-effective-therapeutic-efficacy-in-pancreatic-cancer
#8
Wentao Yang, Qian Hu, Yanmei Xu, Hailang Liu, Lin Zhong
In this study, we have developed an antibody fragment (AF)-conjugated gemcitabine (GEM) and paclitaxel (PTX)-loaded liposome (AF-GPL) to enhance the therapeutic efficacy in pancreatic cancer treatment. The maleimide-thiol chemistry was utilized to conjugate AF on the liposome surface. The dual-drug loaded liposome was nanosized and exhibited a controlled release of both the drugs. Importantly, two drugs have different release pattern over a period of time. The AF-conjugated liposome showed enhanced cellular uptake in pancreatic cancer cells compared to that of non-targeted liposome...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29748577/reversible-glycosidic-switch-for-secure-delivery-of-molecular-nanocargos
#9
Pierre-Alain Burnouf, Yu-Lin Leu, Yu-Cheng Su, Kenneth Wu, Wei-Chi Lin, Steve R Roffler
Therapeutic drugs can leak from nanocarriers before reaching their cellular targets. Here we describe the concept of a chemical switch which responds to environmental conditions to alternate between a lipid-soluble state for efficient cargo loading and a water-soluble state for stable retention of cargos inside liposomes. A cue-responsive trigger allows release of the molecular cargo at specific cellular sites. We demonstrate the utility of a specific glycosidic switch for encapsulation of potent anticancer drugs and fluorescent compounds...
May 10, 2018: Nature Communications
https://www.readbyqxmd.com/read/29746956/liposomal-delivery-of-a-pin1-inhibitor-complexed-with-cyclodextrins-as-new-therapy-for-high-grade-serous-ovarian-cancer
#10
Concetta Russo Spena, Lucia De Stefano, Stefano Palazzolo, Barbara Salis, Carlotta Granchi, Filippo Minutolo, Tiziano Tuccinardi, Roberto Fratamico, Sara Crotti, Sara D'Aronco, Marco Agostini, Giuseppe Corona, Isabella Caligiuri, Vincenzo Canzonieri, Flavio Rizzolio
Pin1, a prolyl isomerase that sustains tumor progression, is overexpressed in different types of malignancies. Functional inactivation of Pin1 restrains tumor growth and leaves normal cells unaffected making it an ideal pharmaceutical target. Although many studies on Pin1 have focused on malignancies that are influenced by sex hormones, studies in ovarian cancer have lagged behind. Here, we show that Pin1 is an important therapeutic target in high-grade serous epithelial ovarian cancer. Knock down of Pin1 in ovarian cancer cell lines induces apoptosis and restrains tumor growth in a syngeneic mouse model...
May 7, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29745927/-new-endovesical-chemotherapy-drugs-and-application-vehicles
#11
Emilio Rios González, Luis Martínez-Piñeiro
Urothelial bladder cancer is a very prevalent disease. At the time of diagnosis 70-80% of the cases present as non muscle invasive tumors. These tumors present a high recurrence and progression rates despite intravesical treatment with Bacille Calmette-Guerin and mitomycin C. Moreover, bladder conditions such as its wall impermeability and the fact that intravesical drugs are constantly being diluted by urine and eliminated do not favor the efficacy of intravesical treatment. This review analyzes new intravesical drugs such as gemcitabine or taxanes with promising results as alternative to the usual treatments or after their failure...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745740/co-delivery-of-gambogenic-acid-and-vegf-sirna-with-anionic-liposome-and-polyethylenimine-complexes-to-hepg2-cells
#12
Qiongfang Yu, Bian Zhang, Yali Zhou, Qin Ge, Chang Jiali, Yunna Chen, Kaiqi Zhang, Daiyin Peng, Weidong Chen
Background and Objective The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the anti-cancer efficiency in HepG2 cells. Methods The delivery system was prepared by a two-step method. Firstly, the GNA anionic liposome took shape by a solvent evaporation method, and then the liposome was bound to the PEI/siRNA complex by electrostatic interaction to form the final carrier system (lipopolyplexes)...
May 10, 2018: Journal of Liposome Research
https://www.readbyqxmd.com/read/29744672/efficacy-and-safety-of-neoadjuvant-treatment-with-bevacizumab-liposomal-doxorubicin-cyclophosphamide-and-paclitaxel-combination-in-locally-regionally-advanced-her2-negative-grade-iii-at-premenopausal-status-breast-cancer-a-phase-ii-study
#13
Ekaterini C Tampaki, Athanasios Tampakis, Constantinos E Alifieris, Dimitrios Krikelis, Anastasia Pazaiti, Michalis Kontos, Dimitrios T Trafalis
BACKGROUND: In the era of personalized therapy, targeted treatment in specific patient populations is mandated. OBJECTIVE: We evaluated the efficacy and safety of neoadjuvant treatment on locally advanced breast cancer (LABC) with a monoclonal agent against vascular endothelial growth factor (VEGF), bevacizumab plus chemotherapy combination of liposomal doxorubicin, cyclophosphamide and paclitaxel (PLAC-B). METHODS: Patients enrolled were at premenopausal status and characterized by human epidermal growth factor receptor 2 (HER2)-negative, hormone-receptor positive (estrogen receptor/progesterone receptor-positive [ER/PR+]) or triple-negative (TNBC), LABC (T > 3 cm), with high-grade ductal carcinoma...
May 9, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29742893/synthesis-liposomal-formulation-and-immunological-evaluation-of-a-minimalistic-carbohydrate-%C3%AE-galcer-vaccine-candidate
#14
Felix Broecker, Sebastian Götze, Jonathan Hudon, Dominea C K Rathwell, Claney L Pereira, Pierre Stallforth, Anish Chakkumkal, Peter H Seeberger
Fully synthetic glycan-based vaccines hold great potential as preventive and therapeutic vaccines against infectious diseases as well as cancer. Here, we present a two-component platform based on the facile conjugation of carbohydrate antigens to α-galactosylceramide (α-GalCer) to yield fully synthetic vaccine candidates. Formulation of a cancer-associated Tn antigen glycolipid model vaccine candidate into liposomes of different sizes and subsequent immunization of mice generated specific, high-affinity antibodies against the carbohydrate antigen with characteristics of T cell-dependent immunity...
May 9, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29740483/reduced-mir-433-expression-is-associated-with-advanced-stages-and-early-relapse-of-colorectal-cancer-and-restored-mir-433-expression-suppresses-the-migration-invasion-and-proliferation-of-tumor-cells-in-vitro-and-in-nude-mice
#15
Jian Zhang, Lei Zhang, Tong Zhang, Xin-Min Dong, Yu Zhu, Long-Hua Chen
The expression of microRNA (miR-433) is altered in various types of human cancer. The present study analyzed the prognostic and biological value of miR-433 expression in colorectal cancer using reverse transcription-quantitative polymerase chain reaction in 125 colorectal tissue specimens (including a test cohort of 40 cases of paired colorectal cancer and adjacent normal mucosae and a confirmation cohort of 85 cases of stage I-III colorectal cancer). In vitro and nude mouse xenograft experiments were subsequently used to assess the effects of miR-433 expression on the regulation of colorectal cancer cell proliferation, adhesion, migration, and invasion...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29737834/ph-controlled-liposomes-for-enhanced-cell-penetration-in-tumor-environment
#16
Michela Barattin, Andrea Mattarei, Anna Balasso, Cristina Paradisi, Laura Cantù, Elena Del Favero, Tapani Viitala, Francesca Mastrotto, Paolo Caliceti, Stefano Salmaso
An innovative pH-switchable colloidal system that can be exploited for site-selective anticancer drug delivery has been generated by liposomes decoration with a new novel synthetic non-peptidic oligo-Arginine cell-penetration enhancer (CPE) and a quenching PEGylated counterpart that detaches from the vesicle surface under the acidic conditions of tumors. The CPE module (Arg4-DAG) is formed by four arginine units conjugated to a first generation (G1) 2,2-bis(hydroxymethyl)propionic acid (bis-MPA)/2,2-bis(aminomethyl)propionic acid (bis-AMPA) polyester dendron terminating with 1,2-distearoyl-3-azidopropane for liposome bilayer insertion...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29731631/arginine-glycine-aspartic-acid-peptide-modified-paclitaxel-and-curcumin-co-loaded-liposome-for-the-treatment-of-lung-cancer-in-vitro-vivo-evaluation
#17
Kanqiu Jiang, Mingjing Shen, Weihua Xu
Purpose: In this study, a novel arginine, glycine, aspartic acid peptide (RGD)-modified paclitaxel and curcumin co-loaded liposomes were developed to evaluate their antitumor activity in vitro and in vivo. Materials and methods: Co-loaded liposomes were prepared using the solvent evaporation method. The particles had spherical shapes under electron microscopy with sizes <130 nm. Results: By comparison with the free drug, RGD-modified paclitaxel and curcumin co-loaded liposomes and paclitaxel and curcumin co-loaded liposomes have sustained-release properties in vitro...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29730175/cisplatin-and-curcumin-co-loaded-nano-liposomes-for-the-treatment-of-hepatocellular-carcinoma
#18
Yao Cheng, Pengxuan Zhao, Shuangping Wu, Tan Yang, Yan Chen, Xiaojuan Zhang, Chuanchuan He, Chao Zheng, Kelin Li, Xiang Ma, Guangya Xiang
Hepatocellular carcinoma (HCC) continues to be a leading cause of cancer related death in the world. Conventional chemotherapeutic agents such as cisplatin (CDDP) have an unsatisfactory efficacy on HCC due to the poor response, severe toxicity and drug resistance. Curcumin (CUR) could improve the chemosensitivity of HCC to chemotherapy drugs by regulating a variety of signaling pathways. Herein, we describe a combination strategy using co-loaded liposomes to effectively deliver and release CDDP and curcumin (CUR) to HCC for overcoming the unsatisfactory clinical outcome of CDDP monotherapy...
May 3, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29730153/potentiating-bacterial-cancer-therapy-using-hydroxychloroquine-liposomes
#19
Ying Wang, Zixuan Zhou, Wenfei Chen, Ming Qin, Zhirong Zhang, Tao Gong, Xun Sun
Salmonella VNP20009 inhibits tumor growth in preclinical models but its efficacy in humans is limited, potentially because cells mount an autophagy response that destroys the therapeutic bacteria. To neutralize this protective response, we combined VNP20009 with long-circulating liposomes containing the autophagy arrest agent hydroxychloroquine. This combination was associated with significantly larger numbers of intracellular Salmonella, accumulated autophagic vacuoles and much greater cell death in vitro...
May 3, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29726618/metformin-s-antitumour-and-anti-angiogenic-activities-are-mediated-by-skewing-macrophage-polarization
#20
Ji-Chang Wang, Xin Sun, Qiang Ma, Gui-Feng Fu, Long-Long Cong, Hong Zhang, De-Fu Fan, Jun Feng, Shao-Ying Lu, Jian-Lin Liu, Guang-Yue Li, Pei-Jun Liu
Beneficial effects of metformin on cancer risk and mortality have been proved by epidemiological and clinical studies, thus attracting research interest in elucidating the underlying mechanisms. Recently, tumour-associated macrophages (TAMs) appeared to be implicated in metformin-induced antitumour activities. However, how metformin inhibits TAMs-induced tumour progression remains ill-defined. Here, we report that metformin-induced antitumour and anti-angiogenic activities were not or only partially contributed by its direct inhibition of functions of tumour and endothelial cells...
May 4, 2018: Journal of Cellular and Molecular Medicine
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