Xingyan An, Fengjin Zhou, Guangfeng Li, Yan Wei, Biaotong Huang, Mengmeng Li, Qin Zhang, Ke Xu, Robert Chunhua Zhao, Jiacan Su
Cyaonoside A (CyA), derived from the natural Chinese medicine, Cyathula officinalis Kuan , which was for a long time used to treat knee injuries and relieve joint pain in traditional Chinese medicine, showed an unclear mechanism for protecting cartilage. In addition, CyA was poorly hydrosoluble and incapable of being injected directly into the joint cavity, which limited its clinical application. This study reveals that CyA resisted IL-1β-mediated chondrogenic inflammation and apoptosis. Next, transcriptome sequencing is used to explore the potential mechanisms underlying CyA regulation of MSC chondrogenic differentiation...
April 9, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine