keyword
MENU ▼
Read by QxMD icon Read
search

knee injection

keyword
https://www.readbyqxmd.com/read/29053693/in-vivo-tracking-of-human-adipose-derived-mesenchymal-stem-cells-in-a-rat-knee-osteoarthritis-model-with-fluorescent-lipophilic-membrane-dye
#1
Meng Li, Ming Hao, Dong Jiang, Yanxi Chen, Wen Wang
In order to support the clinical application of human adipose-derived mesenchymal stem cell (haMSC) therapy for knee osteoarthritis (KOA), we examined the efficacy of cell persistence and biodistribution of haMSCs in animal models. We demonstrated a method to label the cell membrane of haMSCs with lipophilic fluorescent dye. Subsequently, intra-articular injection of the labeled cells in rats with surgically induced KOA was monitored dynamically by an in vivo imaging system. We employed the lipophilic carbocyanines DiD (DilC18 (5)), a far-red fluorescent Dil (dialkylcarbocyanines) analog, which utilized a red laser to avoid excitation of the natural green autofluorescence from surrounding tissues...
October 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29051707/efficacy-of-intra-articular-injection-of-a-newly-developed-plasma-rich-in-growth-factor-prgf-versus-hyaluronic-acid-on-pain-and-function-of-patients-with-knee-osteoarthritis-a-single-blinded-randomized-clinical-trial
#2
Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Azadeh Gharooee Ahangar, Porya Hassan Abadi, Parviz Mojgani, Omid Gharooi Ahangar
BACKGROUND AND OBJECTIVES: Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid (HA) on pain and function of patients with knee osteoarthritis. METHODS: In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29046777/effect-of-palmitoylethanolamide-on-inflammatory-and-neuropathic-pain-in-rats
#3
Tai-Kyung Seol, Wonho Lee, Sunah Park, Kyu Nam Kim, Tae Yeon Kim, You Na Oh, Jong Hun Jun
BACKGROUND: A growing body of evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of mast cells and glial cells, and production of inflammatory mediators in the peripheral and central nervous systems, plays an important role in the induction and maintenance of chronic pain. Palmitoylethanolamide (PEA), which is a type of N-acylethanolamide and a lipid, has an anti-inflammatory effect. Relative to the anti-inflammatory effect, little is known about its analgesic effect in chronic pain...
October 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29044993/intra-articular-hyaluronic-acid-injection-in-treating-knee-osteoarthritis-assessing-risk-of-bias-in-systematic-reviews-with-robis-tool
#4
Dan Xing, Bin Wang, Wei Zhang, Ziyi Yang, Yunfei Hou, Yaolong Chen, Jianhao Lin
OBJECTIVES: Intra-articular injection of hyaluronic acid (HA) is a common, yet controversial therapeutic option in treating knee osteoarthritis (OA). The purpose of the present study was to assess the risk of bias (RoB) of systematic reviews (SRs) and to summarize available evidence of HA in treating knee OA. METHODS: A systematic search of SRs published through to December 2016 was conducted using the MEDLINE, EMBASE and Cochrane Library. The RoB of included SRs was assessed by ROBIS tool...
October 17, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29040402/is-postspinal-hypotension-a-sign-of-impaired-cardiac-performance-in-the-elderly-an-observational-mechanistic-study
#5
J Jakobsson, S H Kalman, M Lindeberg-Lindvet, E Bartha
Background: We have previously reported that stroke volume is reduced in a majority of elderly patients undergoing surgical repair of hip fracture before and after intrathecal injection of anaesthetic. We aimed to investigate these observations further in a prospective study of elderly patients undergoing elective hip or knee arthroplasty under spinal anaesthesia. Methods: Patients ≥65 yr undergoing elective arthroplasty were monitored with LiDCOplus™ preoperatively (baseline), before and continuously for 45 min after spinal anaesthesia...
October 10, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29032478/total-knee-arthroplasty-in-patients-with-a-history-of-illicit-intravenous-drug-abuse
#6
David E Bauer, Andreas Hingsammer, Lukas Ernstbrunner, Alexander Aichmair, Andrea B Rosskopf, Franziska Eckers, Karl Wieser, Sandro F Fucentese
PURPOSE: Injection drug users are at high risk for both infection with blood-borne pathogens, namely, human immune deficiency virus (HIV), hepatitis-B, -C virus, various bacterial infections, as well as early primary and secondary joint degeneration. When total knee arthroplasty (TKA) is anticipated the risk of septic complications is a major concern. The purpose of this study was to assess the clinical and radiographic outcome of patients with a history of intravenous drug use after total knee arthroplasty...
October 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29031987/intra-articular-injection-of-mesenchymal-stem-cells-and-platelet-rich-plasma-to-treat-patellofemoral-osteoarthritis-preliminary-results-of-a-long-term-pilot-study
#7
Julien Pintat, Alain Silvestre, Guy Magalon, Alain Pierre Gadeau, Lionel Pesquer, Anne Perozziello, Alain Peuchant, Charbel Mounayer, Benjamin Dallaudière
PURPOSE: To assess the feasibility and safety of concomitant intra-articular (IA) knee injection of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) under fluoroscopic guidance to treat patellofemoral osteoarthritis (OA). MATERIALS AND METHODS: This prospective study included 19 consecutive patients referred for fluoroscopically guided IA MSC and PRP injection for symptomatic patellofemoral chondropathy in which conservative treatment had failed. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and magnetic resonance (MR) data, including T2 mapping sequence, were prospectively collected before and 6 months after treatment...
October 12, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29027984/the-effect-of-intra-articular-injection-of-autologous-microfragmented-fat-tissue-on-proteoglycan-synthesis-in-patients-with-knee-osteoarthritis
#8
Damir Hudetz, Igor Borić, Eduard Rod, Željko Jeleč, Andrej Radić, Trpimir Vrdoljak, Andrea Skelin, Gordan Lauc, Irena Trbojević-Akmačić, Mihovil Plečko, Ozren Polašek, Dragan Primorac
Osteoarthritis (OA) is one of the leading musculoskeletal disorders in the adult population. It is associated with cartilage damage triggered by the deterioration of the extracellular matrix tissue. The present study explores the effect of intra-articular injection of autologous microfragmented adipose tissue to host chondrocytes and cartilage proteoglycans in patients with knee OA. A prospective, non-randomized, interventional, single-center, open-label clinical trial was conducted from January 2016 to April 2017...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29026354/novel-regional-techniques-for-total-knee-arthroplasty-promote-reduced-hospital-length-of-stay-an-analysis-of-106-patients
#9
Salman Thobhani, Lauren Scalercio, Clint E Elliott, Bobby D Nossaman, Leslie C Thomas, Dane Yuratich, Kim Bland, Kristie Osteen, Matthew E Patterson
BACKGROUND: Novel regional techniques, including the adductor canal block (ACB) and the local anesthetic infiltration between the popliteal artery and capsule of the knee (IPACK) block, provide an alternative approach for controlling pain following total knee arthroplasty (TKA). This study compared 3 regional techniques (femoral nerve catheter [FNC] block alone, FNC block with IPACK, and ACB with IPACK) on pain scores, opioid consumption, performance during physical therapy, and hospital length of stay in patients undergoing TKA...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29026341/benefits-of-different-postoperative-treatments-in-patients-undergoing-knee-arthroscopic-debridement
#10
Cesáreo Trueba Vasavilbaso, Carlos David Rosas Bello, Erla Medina López, Maria Pilar Coronel Granado, José Mario Navarrete Álvarez, Cesáreo Angel Trueba Davalillo, Félix Isaac Gil Orbezo
PURPOSE: To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal pathology and osteoarthritis (OA), under normal clinical practice conditions. PATIENTS AND METHODS: We conducted a prospective, randomized, evaluator-blind, pilot study. After arthroscopy, patients were randomized to receive 1) five injections of HA1 (Suprahyal(®)/Adant(®)); 2) four injections of HA2 (Orthovisc(®)); 3) three injections of HA3 (Synvisc(®)); 4) a single injection of PRP (GPS™ II); or 5) standard care (control)...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29025422/readout-segmented-multi-shot-diffusion-weighted-mri-of-the-knee-joint-in-patients-with-juvenile-idiopathic-arthritis
#11
Alexander Sauer, Mengxia Li, Annette Holl-Wieden, Thomas Pabst, Henning Neubauer
BACKGROUND: Diffusion-weighted MRI has been proposed as a new technique for imaging synovitis without intravenous contrast application. We investigated diagnostic utility of multi-shot readout-segmented diffusion-weighted MRI (multi-shot DWI) for synovial imaging of the knee joint in patients with juvenile idiopathic arthritis (JIA). METHODS: Thirty-two consecutive patients with confirmed or suspected JIA (21 girls, median age 13 years) underwent routine 1.5 T MRI with contrast-enhanced T1w imaging (contrast-enhanced MRI) and with multi-shot DWI (RESOLVE, b-values 0-50 and 800 s/mm(2))...
October 12, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29024802/synovial-and-systemic-pharmacokinetics-pks-of-triamcinolone-acetonide-ta-following-intra-articular-ia-injection-of-an-extended-release-microsphere-based-formulation-fx006-or-standard-crystalline-suspension-in-patients-with-knee-osteoarthritis-oa
#12
V B Kraus, P G Conaghan, H A Aazami, P Mehra, A J Kivitz, J Lufkin, J Hauben, J R Johnson, N Bodick
OBJECTIVE: Intra-articular (IA) corticosteroids relieve osteoarthritis (OA) pain, but rapid absorption into systemic circulation may limit efficacy and produce untoward effects. We compared the pharmacokinetics (PKs) of IA triamcinolone acetonide (TA) delivered as an extended-release, microsphere-based formulation (FX006) vs a crystalline suspension (TAcs) in knee OA patients. METHOD: This Phase 2 open-label study sequentially enrolled 81 patients who received a single IA injection of FX006 (5 mL, 32 mg delivered dose, N = 63) or TAcs (1 mL, 40 mg, N = 18)...
October 9, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29016185/clinical-outcomes-of-knee-osteoarthritis-treated-with-an-autologous-protein-solution-injection-a-1-year-pilot-double-blinded-randomized-controlled-trial
#13
Elizaveta Kon, Lars Engebretsen, Peter Verdonk, Stefan Nehrer, Giuseppe Filardo
BACKGROUND: Osteoarthritis (OA) is a debilitating disease resulting in substantial pain and functional limitations. A novel blood derivative has been developed to concentrate both growth factors and antagonists of inflammatory cytokines, with promising preliminary findings in terms of safety profile and clinical improvement. PURPOSE: To investigate if one intra-articular injection of autologous protein solution (APS) can reduce pain and improve function in patients affected by knee OA in a multicenter, randomized, double-blind, saline-controlled study...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28993845/-new-experimental-strategies-in-cartilage-surgery
#14
REVIEW
L Rackwitz, J C Reichert, O Pullig, U Nöth
BACKGROUND: Cell and growth factor based strategies bear great potential to support the healing processes in cartilage repair and the therapy of osteoarthritic joints. OBJECTIVES: The following review provides an overview of novel experimental strategies for the therapy of focal cartilage defects and osteoarthritis, with emphasis on cell and growth factor based approaches. MATERIALS AND METHODS: The authors summarize their own data regarding the intraarticular injection of stem cells to treat osteoarthritis of the knee and provide a synopsis of the available literature discussing the most significant publications...
October 9, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28992420/improved-chondrotoxic-profile-of-liposomal-bupivacaine-compared-with-standard-bupivacaine-after-intra-articular-infiltration-in-a-porcine-model
#15
K Aaron Shaw, Colleen Moreland, Jeremy Jacobs, Justin M Hire, Richard Topolski, Nathan Hoyt, Stephen A Parada, Craig D Cameron
BACKGROUND: Increasingly, liposomal bupivacaine is being used with multimodal pain management strategies. In vitro investigations have shown decreased chondrotoxicity profiles for liposomal bupivacaine; however, there is no evidence regarding its in vivo effects. Hypothesis/Purpose: This study sought to investigate the in vivo chondrotoxicity of liposomal bupivacaine, hypothesizing that there would be increased chondrocyte viability after exposure to liposomal bupivacaine when compared with standard bupivacaine...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28992367/in-vivo-calcium-imaging-visualizes-peripheral-neuron-sensitization-in-a-surgical-mouse-model-of-osteoarthritis
#16
Rachel E Miller, Yu Shin Kim, Phuong B Tran, Shingo Ishihara, Xinzhong Dong, Richard J Miller, Anne-Marie Malfait
OBJECTIVE: The purpose of this study was to develop a method for analyzing sensory neuron responses to mechanical stimuli in vivo, and to evaluate whether these neuronal responses change after destabilization of the medial meniscus (DMM). METHODS: DMM or sham surgery was performed in 10-week old male C57BL/6 wild-type or Pirt-GCaMP3(+/-) mice. All experiments were performed eight weeks after surgery. Knee and hind paw hyperalgesia were assessed in wild-type mice...
October 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28991061/determination-of-ed50-and-ed95-of-0-5-ropivacaine-in-adductor-canal-block-to-produce-quadriceps-weakness-a-dose-finding-study
#17
David F Johnston, Rakesh V Sondekoppam, Robert Giffin, Robert Litchfield, Sugantha Ganapathy
BACKGROUND AND OBJECTIVES: Adductor canal block (ACB) is popular for knee analgesia because of its favorable effect on quadriceps strength. The aim of this study was to find the minimum volume of local anesthetic, which can be injected into the ACB that would result in quadriceps weakness. METHODS: This nonrandomized study used an up-and-down sequential allocation design. Twenty-six patients scheduled to undergo arthroscopic knee surgery received an ultrasound-guided ACB preoperatively...
November 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28990969/dosimetry-in-radiosynoviorthesis-90y-vs-153sm
#18
Mirta Barbara Torres Berdeguez, Sylvia Thomas, Susie Medeiros, Lidia Vasconcellos de Sá, Felix Mas Milian, Ademir Xavier da Silva
Although there are several radionuclides suitable for radiosynoviorthesis (RSO), not all of them can irradiate deeper synovium. Yttrium-90 (Y) is the beta radionuclide with more penetration range; therefore, it is predominantly used to treat knees. The aim of this paper is to highlight several dosimetry concepts to compare Y and Sm, also discussing the feasibility of implementing a dose planning methodology for both in RSO. The MCNPX Monte Carlo nuclear code version 2.6 was used for calculating S-values from which the activity to be injected into the joint was obtained...
October 5, 2017: Health Physics
https://www.readbyqxmd.com/read/28990574/an-evidence-based-evaluation-on-the-use-of-platelet-rich-plasma-in-orthopedics-a-review-of-the-literature
#19
Nasir Hussain, Herman Johal, Mohit Bhandari
Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed...
2017: SICOT-J
https://www.readbyqxmd.com/read/28990203/drug-induced-immune-hemolytic-anemia-associated-with-anti-vancomycin-complicated-by-a-paraben-antibody
#20
Thomas J Gniadek, Patricia A Arndt, Regina M Leger, Daniel Zydowicz, Edward Y Cheng, Nicole D Zantek
BACKGROUND: Drug-induced immune hemolytic anemia (DIIHA) is rare, but potentially life-threatening. A high index of clinical suspicion is required for diagnosis, since the number of medications known to induce DIIHA continues to expand. Additionally, in vitro antibody reactivity against reagent additives has been reported, which may complicate test interpretation. CASE REPORT: A 61-year-old group A, D+ woman with a history of negative antibody detection tests developed hemolytic anemia on Postoperative Day 7 after repeat incision and drainage of a chronically infected right knee prosthesis...
October 8, 2017: Transfusion
keyword
keyword
58305
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"