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https://www.readbyqxmd.com/read/29667940/the-importance-of-the-saphenous-nerve-block-for-analgesia-following-major-ankle-surgery-a-randomized-controlled-double-blind-study
#1
Siska Bjørn, Wan Yi Wong, Jørgen Baas, Kristian K Nielsen, Jens Børglum, Rasmus Wulff Hauritz, Thomas Fichtner Bendtsen
BACKGROUND AND OBJECTIVES: Major ankle surgery causes intense postoperative pain, and whereas the importance of a sciatic nerve block is well established, the clinical significance of a supplemental saphenous nerve block has never been determined in a prospective, randomized, double-blind, placebo-controlled trial. We hypothesized that a saphenous nerve block reduces the proportion of patients experiencing significant clinical pain after major ankle surgery. METHODS: Eighteen patients were enrolled and received a popliteal sciatic nerve block...
March 26, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29667853/evaluation-and-management-of-subchondral-calcium-phosphate-injection-technique-to-treat-bone-marrow-lesion
#2
Diego Costa Astur, Eduardo Vasconcelos de Freitas, Pedro Barreira Cabral, Caio Carvalho Morais, Bruno Silveira Pavei, Camila Cohen Kaleka, Pedro Debieux, Moises Cohen
Purpose This study aimed to compile available data in medical literature about subchondral calcium phosphate injection, comparing results obtained with this technique, as well as indications, complications, and other important factors in treatment of bone marrow lesions. Designs A literature review using PubMed and Medline database in order to identify works with terms "subchondral calcium phosphate injection," " subchondroplasty®," "bone marrow lesion," and "knee." Eight relevant articles were found...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29664865/do-these-crystals-really-sparkle-commentary-on-an-article-by-philip-g-conaghan-mbbs-phd-fracp-frcp-et-al-effects-of-a-single-intra-articular-injection-of-a-microsphere-formulation-of-triamcinolone-acetonide-on-knee-osteoarthritis-pain-a-double-blinded-randomized
#3
https://www.readbyqxmd.com/read/29664853/effects-of-a-single-intra-articular-injection-of-a-microsphere-formulation-of-triamcinolone-acetonide-on-knee-osteoarthritis-pain-a-double-blinded-randomized-placebo-controlled-multinational-study
#4
Philip G Conaghan, David J Hunter, Stanley B Cohen, Virginia B Kraus, Francis Berenbaum, Jay R Lieberman, Deryk G Jones, Andrew I Spitzer, David S Jevsevar, Nathaniel P Katz, Diane J Burgess, Joelle Lufkin, James R Johnson, Neil Bodick
BACKGROUND: Intra-articular corticosteroids relieve osteoarthritis pain, but rapid systemic absorption limits efficacy. FX006, a novel, microsphere-based, extended-release triamcinolone acetonide (TA) formulation, prolongs TA joint residence and reduces systemic exposure compared with standard TA crystalline suspension (TAcs). We assessed symptomatic benefits and safety of FX006 compared with saline-solution placebo and TAcs. METHODS: In this Phase-3, multicenter, double-blinded, 24-week study, adults ≥40 years of age with knee osteoarthritis (Kellgren-Lawrence grade 2 or 3) and average-daily-pain (ADP)-intensity scores of ≥5 and ≤9 (0 to 10 numeric rating scale) were centrally randomized (1:1:1) to a single intra-articular injection of FX006 (32 mg), saline-solution placebo, or TAcs (40 mg)...
April 18, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29664788/method-for-intraarticular-knee-injection
#5
Daniel M Cushman, Justin C Bosley
No abstract text is available yet for this article.
May 2018: Anesthesiology
https://www.readbyqxmd.com/read/29664106/effect-of-therapeutic-exercise-on-knee-osteoarthritis-after-intra-articular-injection-of-botulinum-toxin-type-a-hyaluronate-or-saline-a-randomized-controlled-trial
#6
Xiao Bao, Jie-Wen Tan, Michael Flyzik, Xian-Cong Ma, Howe Liu, Hui-Yu Liu
OBJECTIVE: To study the effect of therapeutic exercise on knee osteoarthritis after injection of botulinum toxin type A, hyaluronate or saline. METHODS: Sixty participants with knee osteoarthritis were randomly assigned to 3 groups: injection of saline (control) (group A), botulinum toxin type A (group B), or hyaluronate (group C). All participants received therapeutic exercise. Western Ontario and McMaster Universities Osteoarthritis Index questionnaire score, visual analogue scale pain scale, and Medical Outcomes Study 36-item Health Survey were conducted at baseline, and at the end of the 4th and 8th weeks...
April 17, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29656977/liposomal-bupivacaine-vs-plain-bupivacaine-in-periarticular-injection-for-control-of-pain-and-early-motion-in-total-knee-arthroplasty-a-randomized-prospective-study
#7
Jason P Zlotnicki, Brian R Hamlin, Anton Y Plakseychuk, Timothy J Levison, Scott D Rothenberger, Kenneth L Urish
BACKGROUND: The use of multimodal pain regimens has been shown to be an effective technique for the treatment of postoperative pain after total knee arthroplasty. Periarticular injections, of both short-acting and long-acting anesthetics, have emerged as an additional method of providing significant improvement in postoperative pain relief. The purpose of this study is to compare the efficacy of periarticular injection using long-acting vs short-acting preparations. METHODS: A randomized, prospective study of 80 consecutive patients was performed comparing liposomal bupivacaine vs plain bupivacaine periarticular injection...
March 16, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29656808/injections-for-knee-osteoarthritis-corticosteroids-viscosupplementation-platelet-rich-plasma-and-autologous-stem-cells
#8
David M Levy, Kyle A Petersen, Margie Scalley Vaught, David R Christian, Brian J Cole
This article reviews the benefits of corticosteroid, viscosupplementation, platelet-rich plasma, and autologous mesenchymal stem cell injections for the treatment of patients with knee osteoarthritis. Integrating injections into both clinical and surgical practices is complicated given existing health insurance reimbursement policies. This review describes the outcomes associated with these interventions and appropriate methods of navigating the existing reimbursement pathways to help providers implement these treatments into their practices...
April 12, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29656143/quantitative-imaging-of-bone-cartilage-interactions-in-acl-injured-patients-with-pet-mri
#9
Feliks Kogan, Audrey P Fan, Uche Monu, Andrei Iagaru, Brian A Hargreaves, Garry E Gold
OBJECTIVE: To investigate changes in bone metabolism by PET, as well as spatial relationships between bone metabolism and MRI quantitative markers of early cartilage degradation, in ACL-reconstructed knees. DESIGN: Both knees of 15 participants with unilateral reconstructed ACL tears and unaffected contralateral knees were scanned using a simultaneous 3.0T PET-MRI system following injection of 18 F-sodium fluoride(18 F-NaF). The maximum pixel standardized uptake value(SUVmax ) in the subchondral bone and the average T2 relaxation time in cartilage were measured in each knee in 8 knee compartments...
April 12, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29650603/top-studies-relevant-to-primary-care-practice
#10
REVIEW
Danielle Perry, Michael R Kolber, Christina Korownyk, Adrienne J Lindblad, Jamil Ramji, Joey Ton, G Michael Allan
OBJECTIVE: To summarize 10 high-quality studies from 2017 that have strong relevance to primary care practice. QUALITY OF EVIDENCE: Study selection involved routine literature surveillance by a group of primary care health professionals. This included screening abstracts of important journals and Evidence Alerts, as well as searching the American College of Physicians Journal Club. MAIN MESSAGE: Topics of the 2017 articles include whether treating subclinical hypothyroidism improves outcomes or symptoms; whether evolocumab reduces cardiovascular disease as well as low-density lipoprotein levels; whether lifestyle interventions reduce medication use in patients with diabetes; whether vitamin D prevents cardiovascular disease, cancer, or upper respiratory tract infections; whether canagliflozin reduces clinical events in patients with diabetes; how corticosteroid injections affect knee osteoarthritis; whether drained abscesses benefit from antibiotic treatment; whether patients with diabetes benefit from bariatric surgery; whether exenatide reduces clinical events in patients with diabetes; and whether tympanostomy tubes affect outcomes in recurrent acute otitis media or chronic otitis media...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650413/taurine-protects-against-knee-osteoarthritis-development-in-experimental-rat-models
#11
Yiqun Bian, Meng Zhang, Kai Wang
BACKGROUND: Osteoarthritis (OA) is one of the complex diseases that affect a large population of the world. The aim of the current study was to explore the roles of taurine in OA rat models, and discover the related mechanisms. METHODS: OA rat models were established by anterior cruciate ligament transection (ACLT) plus medial meniscus resection (MMx) surgery on the right knees. Secondary mechanical allodynia, weight-bearing alterations and knee joint width were evaluated before surgery and every two weeks after surgery...
April 9, 2018: Knee
https://www.readbyqxmd.com/read/29644875/a-single-intra-articular-injection-of-gel-200-for-treatment-of-symptomatic-osteoarthritis-of-the-knee-is-more-effective-than-phosphate-buffered-saline-at-6-months-a-subgroup-analysis-of-a-multicenter-randomized-controlled-trial
#12
Junko Takamura, Takayuki Seo, Vibeke Strand
Objective Many clinical trials of viscosupplementation have been conducted, although only the Gel-200 (primary) trial included a different patient population. A subgroup analysis of a multicenter, randomized controlled trial comparing the efficacy of single intra-articular injections of Gel-200 with phosphate buffered saline (PBS) was performed to demonstrate its benefit as treatment of osteoarthritis of the knee in a population similar to those of other reported trials of viscosupplementation. Design The subgroup population was defined as patients in the intention-to-treat (ITT) population who met the specified criteria...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29628196/effectiveness-of-novel-adjuncts-in-pain-management-following-total-knee-arthroplasty-a-randomized-clinical-trial
#13
Juan C Suarez, Ahmed A Al-Mansoori, Sumit Kanwar, Jesus M Villa, Colin A McNamara, Preetesh D Patel
BACKGROUND: Total knee arthroplasty (TKA) can be associated with significant pain which can negatively impact outcomes. Multiple strategies have been employed to reduce pain. The aim of this study is to compare the effectiveness of 3 different pain management modalities after TKA that included (1) our standardized knee injection cocktail and oral acetaminophen, (2) liposomal bupivacaine periarticular injection and oral acetaminophen, and (3) our standardized knee injection cocktail and intravenous (IV) acetaminophen...
March 12, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29627848/fixation-augmentation-using-calcium-phosphate-bone-substitute-improves-outcomes-of-complex-tibial-plateau-fractures-a-matched-cohort-study
#14
Matthieu Ollivier, Yassine Bulaïd, Christophe Jacquet, Sebastien Pesenti, Jean-Noel Argenson, Sebastien Parratte
INTRODUCTION: Injectable cements have been developed to improve fixation's stability and thus obtain early return to adequate joint function. We aimed to compare post-operative radiographic and clinical outcomes of patients suffering from a complex tibial plateau fracture (TPF) fixed with calcium-phosphate bone substitutes (CPBS) augmentation to a matched group of patients with identical fracture pattern, treated with the same fixation's type, but augmented with bone grafting. METHODS: After local ethic committee approval, we retrospectively identified in a prospectively collected database, patients with complex comminuted metaphyseal and epiphysial bicondylar TPF (Schatzker type VI) admitted in our emergency department between January 2011 and December 2013...
April 7, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29627623/encapsulation-of-trans-aconitic-acid-in-mucoadhesive-microspheres-prolongs-the-anti-inflammatory-effect-in-lps-induced-acute-arthritis
#15
Diego Pinto de Oliveira, Gabriela Guimarães Augusto, Nathália Vieira Batista, Vivian Louise S de Oliveira, Diêgo Santos Ferreira, Mateus Araújo Castro E Souza, Christian Fernandes, Flávio Almeida Amaral, Mauro Martins Teixeira, Rodrigo Maia de Pádua, Mônica Cristina Oliveira, Fernão Castro Braga
trans-Aconitic acid (TAA) is the main constituent of the leaves from the medicinal plant Echinodorus grandiflorus, used to treat different inflammatory diseases. TAA induces a potent but short-lasting biological response, credited to its high polarity and unfavorable pharmacokinetics. Here we developed, characterized and evaluated the anti-inflammatory activity of mucoadhesive microspheres loaded with TAA. Seven batches of mucoadhesive microspheres were prepared by the emulsification/solvent evaporation method, employing different proportions of TAA and Carbopol 934 or/and hydroxypropylmethylcellulose...
April 5, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29624738/meniscal-extrusion-and-degeneration-during-the-course-of-osteoarthritis-in-the-murine-collagenase-induced-osteoarthritis-model
#16
Lizette Utomo, Susanne M Eijgenraam, Duncan E Meuffels, Sita M A Bierma-Zeinstra, Yvonne M Bastiaansen-Jenniskens, Gerjo J V M van Osch
Meniscal damage is, despite its major role in knee osteoarthritis (OA), often neglected in OA animal models. We evaluated structural meniscal degeneration during the course of OA in the murine collagenase-induced OA (CIOA) model. To investigate this, OA was induced in the knee joints of 33 male C57BL/6 mice by an intra-articular injection of 10U collagenase. The mice were sacrificed after 1, 3, 7, 14, 28, and 56 days, and the knees were harvested and processed for histological analysis. As control, 6 knees were obtained from 16-week-old mice in which no OA was induced...
April 6, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29618150/a-meta-analysis-comparing-liposomal-bupivacaine-and-traditional-periarticular-injection-for-pain-control-after-total-knee-arthroplasty
#17
Hao Sun, Zhiyu Huang, Zhiqi Zhang, Weiming Liao
Liposomal bupivacaine is a novel method for pain control after total knee arthroplasty (TKA), but recent studies showed no advantage for patients undergoing TKA compared with traditional periarticular injection (PAI). The purpose of this analysis was to compare the clinical outcomes between liposomal bupivacaine treatment and traditional PAI. We retrospectively reviewed data from 16 clinical trials in published databases from their inception to June 2017. The primary outcome was postoperative Visual Analogue Scale (VAS) score and secondary outcomes included opiate usage, narcotic consumption, range of motion, and length of stay...
April 4, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29618143/efficacy-and-safety-of-hylan-versus-hyaluronic-acid-in-the-treatment-of-knee-osteoarthritis
#18
Wen-Li Dai, Ze-Ming Lin, Dong-Hong Guo, Zhan-Jun Shi, Jian Wang
The purpose of this study was to use meta-analytic approach to compare the efficacy and safety of intraarticular hylan and hyaluronic acid (HA) for knee osteoarthritis (OA) treatment. We searched PubMed, Embase, and the Cochrane databases through July 2017 to identify Level I randomized controlled trials (RCTs) that evaluated clinical efficacy and safety of hylan compared with HA for knee OA. The primary outcomes were Visual Analogue Scale (VAS) for pain and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, and WOMAC function scores...
April 4, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29610937/paediatric-musculoskeletal-disease-in-kumi-district-uganda-a-cross-sectional-survey
#19
Kristin Alves, Norgrove Penny, Olive Kobusingye, Robert Olupot, Jeffrey N Katz, Coleen S Sabatini
PURPOSE: The purpose of this study is to estimate the burden of musculoskeletal disease among children treated in Kumi District, Uganda, to inform training, capacity-building efforts, and resource allocation. METHODS: We conducted a retrospective cohort study by reviewing the musculoskeletal (MSK) clinic and community outreach logs for children (age < 18 years) seen at Kumi Hospital in Kumi, Uganda, between January 2013 and December 2015. For each patient, we recorded the age, sex, diagnosis, and treatment recommendation...
April 2, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29610039/botulinum-toxin-type-a-treatment-combined-with-intensive-rehabilitation-for-gait-poststroke-a-preliminary-study
#20
Yuki Uchiyama, Tetsuo Koyama, Yosuke Wada, Masashi Katsutani, Norihiko Kodama, Kazuhisa Domen
GOAL: To examine the effects of botulinum toxin type A (BoNT-A) treatment combined with intensive rehabilitation for gait compared with intensive rehabilitation alone in patients with chronic stroke. MATERIALS AND METHODS: A comparative case series design was used. Subjects were 19 patients with chronic stroke and spastic hemiplegia. In 9 patients (group I), BoNT-A was injected into spastic muscles of the affected lower limbs, followed by a 4-week inpatient intensive rehabilitation program...
March 30, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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