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https://www.readbyqxmd.com/read/29601353/how-to-diagnose-food-allergy
#1
Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa
PURPOSE OF REVIEW: To assess the recent studies that focus on specific immunoglobulin E (sIgE) testing and basophil activation test (BAT) for diagnosing IgE-mediated food allergies. RECENT FINDINGS: The sIgE to allergen extract or component can predict reactivity to food. The cutoff value based on the positive predictive value (PPV) of sIgE can be considered whenever deciding whether oral food challenge (OFC) is required to diagnose hen's egg, cow's milk, wheat, peanut, and cashew nut allergy...
March 29, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29576253/nutritional-management-of-cow-s-milk-allergy-in-children-an-update
#2
C Dupont, J-P Chouraqui, A Linglart, A Bocquet, D Darmaun, F Feillet, M-L Frelut, J-P Girardet, R Hankard, J-C Rozé, U Simeoni, A Briend
Cow's milk is one of the most common foods responsible for allergic reactions in children. Cow's milk allergy (CMA) involves immunoglobulin E (IgE)- and non-IgE-mediated reactions, the latter being both variable and nonspecific. Guidelines thus emphasize the need for physicians to recognize the specific syndromes of CMA and to respect strict diagnostic modalities. Whatever the clinical pattern of CMA, the mainstay of treatment is the elimination from the diet of cow's milk proteins. The challenge is that both the disease and the elimination diet may result in insufficient height and weight gain and bone mineralization...
March 22, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29571475/gut-peptidases-from-a-specialist-herbivore-of-latex-plants-are-capable-of-milk-protein-hydrolysis-inputs-for-hypoallergenic-milk-formulas
#3
João P B Oliveira, Márcio V Ramos, Francisco E S Lopes, Igor C Studart, Jefferson S Oliveira, Marina D P Lobo, Ana C O Monteiro-Moreira, Cleverson D T Freitas
Transitory allergies to cow milk proteins in infants or adults have become a public health problem. Although extensively or partially hydrolyzed cow milk protein formulas are available, these products are costly. Therefore, studies into innovative enzymes to digest cow milk proteins are needed. Danaus plexippus gut peptidases were purified and examined with regard to cow milk protein hydrolysis. The peptidases hydrolyzed caseins and whey proteins. However, after heat treatment, there was a significant improvement in β-lactoglobulin hydrolysis...
July 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29556760/consumption-of-soy-based-infant-formula-is-not-associated-with-early-onset-of-puberty
#4
Tali Sinai, Shely Ben-Avraham, Inbal Guelmann-Mizrahi, Michael R Goldberg, Larisa Naugolni, Galia Askapa, Yitzhak Katz, Marianna Rachmiel
PURPOSE: The use of soy products is common in young children with cow milk allergy (CMA). The aim was to examine prospectively the association between infantile consumption of soy-based formula, growth parameters and early pubertal signs, in comparison to cow milk-based formula. METHODS: A nested case-control study was conducted, selected from a cohort of infants prospectively followed from birth until the age of 3 years for eating habits and the development of IgE-mediated CMA...
March 20, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29555204/-anti-tissue-transglutaminase-antibodies-not-related-to-gluten-intake
#5
Mónica Garcia-Peris, Ester Donat Aliaga, María Roca Llorens, Etna Masip Simó, Begoña Polo Miquel, Carmen Ribes Koninckx
INTRODUCTION: Anti-tissue transglutaminase antibodies (tTG) have high specificity for coeliac disease (CD). However, positive anti-tTG antibodies have been described in non-coeliac patients. Aim To assess positive anti-tTG antibodies not related to gluten intake. PATIENTS AND METHODS: Retrospective review and follow up conducted on patients with suspected CD (increase anti-tTG levels and gastrointestinal symptoms) but with atypical serology results, positive anti-tTG with gluten free diet and a decrease in anti-tTG levels despite gluten intake...
March 16, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29549703/anaphylaxis-to-cutaneous-exposure-to-bovine-colostrum-based-cream
#6
Federica Porcaro, Lucia Caminiti, Giuseppe Crisafulli, Francesco Guglielmo, Giovanni Battista Pajno
Children who are highly sensitive to milk may also have severe allergic reactions after exposure to cow's milk proteins(CMP) through a different administration route than the oral one. We describe the case of a 16-year-old Caucasian boy with a clinical history of persistent cow's milk allergy (CMA), who developed one episode of anaphylaxis following cutaneous application of a bovine colostrum containing cream to a surgical wound. UniCAP testing showed a significant elevation in specific IgE antibodies to whey milk proteins...
March 12, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29538498/-anaphylaxis-related-to-measles-mumps-and-rubella-vaccine-in-santa-catarina-state-brazil-2014-and-2015
#7
Francieli Fontana Sutile Tardetti Fantinato, Alexander Vargas, Sandra Maria Deotti Carvalho, Carla Magda Allan Santos Domingues, Gisele Barreto, Arieli Schiessl Fialho, Roselita Heinen da Silva, Eduardo Saad, Ivonne Natalia Solarte Agredo
The study aimed to describe cases and verify the frequency of anaphylaxis related to measles, mumps, and rubella (MMR) vaccine produced by manufacturer A and to assess associated risk factors. This was a case-control study (1:4) in Santa Catarina State, Brazil, from July 14, 2014, to January 12, 2015, in children from one year to less than five years of age, vaccinated with MMR and reported with anaphylaxis, while the controls were without anaphylaxis. The measure of association was odds ratio (OR) with 95% confidence interval (95%CI), using the chi-square and Fisher's exact tests...
March 12, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29494340/sanjad-sakati-syndrome-with-macrocytic-anemia-and-failure-to-thrive-a-case-from-south-jordan
#8
Salma A Ajarmeh, Eyad M Al Tamimi
Backgorund: Sanjad-Sakati syndrome (SSS) is a rare autosomal recessive disease caused by a deletion mutation (155-166del) in exon 3 of the TBCE gene on chromosome 1q42-43. The syndrome is characterized by primary hypoparathyroidism, typical dysmorphic features and severe growth retardation. CASE PRESENTATION: We encountered a 2-year-old boy with hypocalcemia, failure to thrive and macrocytic anemia. The patient had the characteristic features of SSS and genetic testing confirmed that he was homozygous for the TBCE mutation...
March 1, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29490044/apical-to-basolateral-transepithelial-transport-of-cow-s-milk-caseins-by-intestinal-caco-2-cell-monolayers-ms-based-quantitation-of-cellularly-degraded-%C3%AE-and-%C3%AE-casein-fragments
#9
Nao Sakurai, Shunsuke Nishio, Yuka Akiyama, Shinji Miyata, Kenzi Oshima, Daita Nadano, Tsukasa Matsuda
Casein is the major milk protein to nourish infants but, in certain population, it causes cow's milk allergy, indicating the uptake of antigenic casein and their peptides through the intestinal epithelium. Using human intestinal Caco-2 cell monolayers, the apical-to-basal transepithelial transport of casein was investigated. Confocal microscopy using component-specific antibodies showed that αs1-casein antigens became detectable as punctate signals at the apical-side cytoplasm and reached to the cytoplasm at a tight-junction level within a few hours...
February 27, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29483908/cow-s-milk-and-immune-function-in-the-respiratory-tract-potential-mechanisms
#10
REVIEW
Olaf Perdijk, Marloes van Splunter, Huub F J Savelkoul, Sylvia Brugman, R J Joost van Neerven
During the last decades, the world has witnessed a dramatic increase in allergy prevalence. Epidemiological evidence shows that growing up on a farm is a protective factor, which is partly explained by the consumption of raw cow's milk. Indeed, recent studies show inverse associations between raw cow's milk consumption in early life and asthma, hay fever, and rhinitis. A similar association of raw cow's milk consumption with respiratory tract infections is recently found. In line with these findings, controlled studies in infants with milk components such as lactoferrin, milk fat globule membrane, and colostrum IgG have shown to reduce respiratory infections...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29483800/levels-of-inflammatory-cytokines-from-peripheral-blood-mononuclear-cells-of-children-with-cow-s-milk-protein-allergy
#11
Maria D'Apolito, Angelo Campanozzi, Ida Giardino, Massimo Pettoello-Mantovani
Aim: The aim of the study was to investigate the level of cytokines in cultures of cow's milk protein- stimulated peripheral blood mononuclear cells of patients with cow's milk protein allergy. Material and Methods: Eleven children with cow's milk protein allergy and 11 non-allergic controls were studied. Their peripheral blood mononuclear cells were cultured alone and in the presence of cow's milk α-lactalbumin; β-lactoglobulin; αS 1, αS 2, β, and κ-casein fraction mixtures; and a cow's protein mixture from whole milk...
December 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/29481443/micronutrient-status-and-nutritional-intake-in-0-2-year-old-children-consuming-a-cows-milk-exclusion-diet
#12
Janne Anita Kvammen, Rut Anne Thomassen, Mari Borge Eskerud, Jarle Rugtveit, Christine Henriksen
OBJECTIVES AND STUDY: To study micronutrient status and nutritional intake from complementary feeding in children on a cows' milk exclusion (CME) diet. METHODS: Fifty-seven children with cows' milk allergy, aged < 2 years, were included in a cross-sectional study. Blood was analysed for micronutrient status. Complementary feeding was defined as all solids and liquids except of breastmilk, and assessed by 3-day food diary. The results were analysed according to three feeding patterns: mainly breastfed (mBF), partially breastfed (pBF) and no breastmilk group (nBM)...
February 23, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29477244/iberian-consensus-on-cow-s-milk-allergy-the-cibal-study
#13
E Alonso-Lebrero, L Bento, A Martorell-Aragonés, L Ribeiro
BACKGROUND: The present study explores the professional opinion of a wide range of experts from the Iberian Peninsula (Spain and Portugal) and their degree of consensus about CMPA's prevention, diagnosis, treatment and progression. MATERIAL AND METHODS: A 57-item survey divided in four blocks: Prevention (14 items), Diagnosis (10 items), Treatment (19 items) and Progression (14 items) was completed by 160 panellists, experts in CPMA management (116 Spain, 44 Portugal)...
February 21, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29467686/the-role-of-personality-in-daily-food-allergy-experiences
#14
Tamlin S Conner, Miranda Mirosa, Phil Bremer, Rana Peniamina
Food allergies present numerous challenges to coping in everyday life. Even simple things like planning a lunch with a friend can be stressful for people with food allergies. But are some people more adversely impacted by having a food allergy than other people? This paper addressed this question by investigating whether individual differences in the Big Five personality traits (neuroticism, extraversion, openness, agreeableness, and conscientiousness) are related to food allergy-related problems in everyday life among adults with food allergies...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29461665/children-with-cow-s-milk-allergy-following-an-elimination-diet-had-normal-growth-but-relatively-low-plasma-leptin-at-age-two
#15
Ping Dong, Jing-Jing Feng, Dong-Yong Yan, Yu-Jing Lyu, Xiu Xu
AIM: To assess nutrient intake, growth and nutritional status of infants with cow's milk allergy (CMA) who follow a therapeutic elimination diet since the first few months of life. METHODS: Sixty infants younger than four months of age with challenge-proven CMA and 60 healthy age-matched children were investigated. Anthropometric and body composition (BC) were assessed up to 24 months. Dietary intake was recorded by the parents for three consecutive days before visits at 6, 12, 18 and 24 months...
February 20, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29457221/association-of-stat6-gene-variants-with-food-allergy-diagnosed-by-double-blind-placebo-controlled-food-challenges
#16
C D van Ginkel, M E Pettersson, A E J Dubois, G H Koppelman
This study describes the role of two STAT6 gene variants in food allergy using data of patients and their parents who underwent double-blind placebo-controlled food challenges (DBPCFCs). After quality control, 369 trios were analyzed including 262 children (71.0%) with food allergy. Associations were tested by family based association testing (FBAT). The A alleles of both SNPs were associated with food allergy (p=0.036 and p=0.013 for rs324015 and rs1059513, respectively). Furthermore, these A alleles were associated with peanut allergy, higher sIgE levels to both peanut and cow's milk, more severe symptoms and higher eliciting doses during peanut and cow's milk DBPCFCs (all p<0...
February 19, 2018: Allergy
https://www.readbyqxmd.com/read/29428389/allergenicity-reduction-of-bovine-milk-%C3%AE-lactoglobulin-by-proteolytic-activity-of-lactococcus-lactis-bmc12c-and-bmc19h-isolated-from-iranian-dairy-products
#17
Rezvan Kazemi, Asghar Taheri-Kafrani, Ahmad Motahari, Reihane Kordesedehi
Nowadays health benefits of bioactive food constituents, known as probiotic microorganisms, are a growing awareness. Cow's milk is a nutritious food containing probiotic bacteria. However, milk allergenicity is one of the most common food allergies. The milk protein, β-lactoglobulin (BLG), is in about 80% of all main cases of milk allergies for children and infants. With the aim of screening proteolytic strains of lactic acid bacteria to evaluate their potential for the reduction of allergenicity of the major bovine milk proteins, we isolated new proteolytic strains of cocci lactic acid bacteria from traditional Iranian dairy products...
February 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29416848/correction-to-better-recognition-diagnosis-and-management-of-non-ige-mediated-cow-s-milk-allergy-in-infancy-imap-an-international-interpretation-of-the-map-milk-allergy-in-primary-care-guideline
#18
Carina Venter, Trevor Brown, Rosan Meyer, Joanne Walsh, Neil Shah, Anna Nowak-Węgrzyn, Tong-Xin Chen, David M Fleischer, Ralf G Heine, Michael Levin, Mario C Vieira, Adam T Fox
[This corrects the article DOI: 10.1186/s13601-017-0162-y.].
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29411703/social-media-as-a-tool-for-the-management-of-food-allergy-in-children
#19
A Alvarez-Perea, P Cabrera-Freitag, V Fuentes-Aparicio, S Infante, L Zapatero, J M Zubeldia
BACKGROUND: Food allergy heavily impairs quality of life. Avoiding the offending food requires extensive patient education. Social media have been proven a useful source of information for other chronic conditions. Our aim was to describe how pediatric patients with food allergy and their families are using social media. METHODS: We performed a cross-sectional study in the Pediatric Allergy Unit of a third-level hospital. Patients with food allergy were surveyed about their disease and the use of social media...
February 7, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29408543/precision-medicine-in-cow-s-milk-allergy-proteomics-perspectives-from-allergens-to-patients
#20
Enza D'Auria, Chiara Mameli, Cristian Piras, Lucia Cococcioni, Andrea Urbani, Gian Vincenzo Zuccotti, Paola Roncada
Cow's milk allergy (CMA) is one of the most common food allergies, especially during childhood. CMA is an immunological mediated adverse reaction to one or more cow's milk proteins, which are normally harmless to a non-allergic individual, as the result of a failure of oral tolerance. To make a correct diagnosis of CMA and a proper treatment is critical in clinical practice. Application of proteomics along with new bio-informatics tools in the field of food allergy is one of the hot topics presented in recent years...
February 3, 2018: Journal of Proteomics
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