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Cows milk allergy

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https://www.readbyqxmd.com/read/29234055/oral-immunotherapy-combined-with-omalizumab-for-high-risk-cow-s-milk-allergy-a-randomized-controlled-trial
#1
Masaya Takahashi, Kazuhiko Soejima, Shoichiro Taniuchi, Yasuko Hatano, Sohsaku Yamanouchi, Hideki Ishikawa, Makoto Irahara, Youhei Sasaki, Hiroshi Kido, Kazunari Kaneko
We evaluated the efficacy and safety of oral immunotherapy (OIT) combined with 24 weeks of omalizumab (OMB) at inducing desensitization in children with cow's milk allergy (CM) compared with an untreated group. The present study was a prospective randomized controlled trial. Sixteen patients (age, 6-14 years) with high IgE levels to CM were enrolled in the present study. Patients were randomized 1:1 to receive OMB-OIT group or untreated group. The primary outcome was the induction of desensitization at 8 weeks after OMB was discontinued in OMB-OIT treated group and at 32 weeks after study entry...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29223706/cross-over-clinical-trial-for-evaluating-the-safety-of-camel-s-milk-intake-in-patients-who-are-allergic-to-cow-s-milk-protein
#2
E M Navarrete-Rodríguez, L A Ríos-Villalobos, C R Alcocer-Arreguín, B E Del-Rio-Navarro, J M Del Rio-Chivardi, O J Saucedo-Ramírez, J J L Sienra-Monge, R V Frias
BACKGROUND: Cow's milk protein allergy (CMPA) affects between 0.6 and 0.9% of the general population, and its treatment implies the total elimination of the intake of this protein. Camel's milk has been suggested as an alternative for patients over one year of age who suffer from CMPA due to the difference in the amino acid sequence from that of cow's milk. The objective of this study was to evaluate the safety and tolerability of camel's milk in children with CMPA. METHODS: Crossed clinical trial for the use of camel's milk vs...
December 6, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29220053/the-mechanism-of-reduced-igg-ige-binding-of-%C3%AE-lactoglobulin-by-pulsed-electric-field-pretreatment-combined-with-glycation-revealed-by-ecd-fticr-ms
#3
Wenhua Yang, Zongcai Tu, Hui Wang, Lu Zhang, Igor A Kaltashov, Yunlong Zhao, Chendi Niu, Honglin Yao, Wenfeng Ye
Bovine β-lactoglobulin (β-Lg) is a major allergen existing in milk and causes about 90% of IgE-mediated cow's milk allergies. Previous studies showed that pulsed electric field (PEF) treatment could partially unfold the protein, which may contribute to the improvement of protein glycation. In this study, the effect of PEF pretreatment combined with glycation on the IgG/IgE-binding ability and the structure of β-Lg was investigated. The result showed that PEF pretreatment combined with glycation significantly reduced the IgG and IgE binding abilities, which was attributed to the changes of secondary and tertiary structure and the increase in glycation sites and degree of substitution per peptide (DSP) value determined by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry (ECD/FTICR-MS)...
December 8, 2017: Food & Function
https://www.readbyqxmd.com/read/29218832/necrotizing-enterocolitis-in-the-setting-of-milk-allergy-after-pediatric-living-donor-liver-transplantation
#4
Soichi Narumoto, Seisuke Sakamoto, Hajime Uchida, Kengo Sasaki, Takanobu Shigeta, Akinari Fukuda, Shunsuke Nosaka, Rie Irie, Takako Yoshioka, Mureo Kasahara
NEC is an idiopathic intestinal mucosal injury that may progress to transmural bowel necrosis without mesenteric ischemia. NEC usually affects 7- to 10-day-old neonates following enteral feeding. A 10-month-old girl with no history of laparotomy underwent LDLT for acute liver failure. After starting enteral feeding on postoperative day 5, she developed abdominal distention. Diffuse PVG and PI were detected by radiologic modalities. Exploratory laparotomy revealed patchy necrosis of the intestine without perforation...
December 7, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29210890/allergic-colitis-with-pneumatosis-intestinalis-in-an-infant
#5
Helena Liu, Troy W S Turner
Inflammatory causes of bloody diarrhea during infancy include necrotizing enterocolitis and allergic colitis, often due to cow's milk protein. We report this case of cow's milk protein allergy, managed successfully with elimination of dietary antigen, to highlight the unusual finding of pneumatosis intestinalis on abdominal x-ray, a radiographic hallmark associated with necrotizing enterocolitis. Detailed patient's history, clinical presentation, and physical examinations are discussed for cow's milk protein allergy and necrotizing enterocolitis...
November 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29205393/eaaci-guidelines-on-allergen-immunotherapy-ige-mediated-food-allergy
#6
G B Pajno, M Fernandez-Rivas, S Arasi, G Roberts, C A Akdis, M Alvaro-Lozano, K Beyer, C Bindslev-Jensen, W Burks, M Ebisawa, P Eigenmann, E Knol, K C Nadeau, L K Poulsen, R van Ree, A F Santos, G du Toit, S Dhami, U Nurmatov, Y Boloh, M Makela, L O'Mahony, N Papadopoulos, C Sackesen, I Agache, E Angier, S Halken, M Jutel, S Lau, O Pfaar, D Ryan, G Sturm, E-M Varga, R G van Wijk, A Sheikh, A Muraro
Food allergy can result in considerable morbidity, impairment of quality of life, and healthcare expenditure. There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy (FA-AIT) through the oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. This Guideline, prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Task Force on Allergen Immunotherapy for IgE-mediated Food Allergy, aims to provide evidence-based recommendations for active treatment of IgE-mediated food allergy with FA-AIT...
September 27, 2017: Allergy
https://www.readbyqxmd.com/read/29202914/integrating-allergen-analysis-within-a-risk-assessment-framework-approaches-to-development-of-targeted-mass-spectrometry-methods-for-allergen-detection-and-quantification-in-the-ifaam-project
#7
Chiara Nitride, Victoria Lee, Ivona Baricevic-Jones, Karine Adel-Patient, Sabine Baumgartner, E N Clare Mills
Allergen analysis is central to implementing and monitoring food allergen risk assessment and management processes by the food industry, but current methods for the determination of allergens in foods give highly variable results. The European Union-funded "Integrated Approaches to Food Allergen and Allergy Risk Management" (iFAAM) project has been working to address gaps in knowledge regarding food allergen management and analysis, including the development of novel MS and immuno-based allergen determination methods...
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29176842/allergenic-food-introduction-and-risk-of-childhood-atopic-diseases
#8
Niels J Elbert, Jessica C Kiefte-de Jong, Trudy Voortman, Tamar E C Nijsten, Nicolette W de Jong, Vincent W V Jaddoe, Johan C de Jongste, Roy Gerth van Wijk, Liesbeth Duijts, Suzanne G M A Pasmans
BACKGROUND: The role of timing and diversity of allergenic food introduction in the development of childhood allergic sensitization and atopic diseases is controversial. OBJECTIVE: To examine whether timing and diversity of allergenic food introduction are associated with allergic sensitization, allergy and eczema in children until age 10 years. MATERIALS AND METHODS: This study among 5,202 children was performed in a population-based prospective cohort...
2017: PloS One
https://www.readbyqxmd.com/read/29169718/-update-on-dietary-management-of-cow-s-milk-allergy
#9
C Dupont, P Soulaines
Dietary management of cow's milk allergy is based on the elimination of all cow's milk proteins from the diet. For non-breastfed infants, the main dietetic move is the replacement of the standard infant formula with a formula for which the protein fraction has been modified. This formula can be based on hydrolyzed cow's milk proteins, rice proteins or amino acids. Monitoring the growth of these children is essential. The reintroduction of cow's milk, raw or heated, should always be made carefully and gradually...
November 20, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29161056/de-novo-food-allergy-in-pediatric-liver-transplantation-recipients
#10
Ratchaneewan Sinitkul, Wiparat Manuyakorn, Wasu Kamchaisatian, Soamarat Vilaiyuk, Suwat Benjaponpitak, Chatmanee Lertudompholwanit, Suporn Treepongkaruna
BACKGROUND: Food allergy (FA) prevalence is increasing in pediatric liver transplantation (LT). However, the clinical course is still limited. OBJECTIVE: This retrospective cohort study aimed to identify the prevalence, risk factors, and the natural history of de novo FA in children post LT. METHODS: Medical records of pediatric LT recipients from Jan 2001 - Dec 2014 were reviewed. De novo FA was diagnosed by symptoms after exposure to culprit food occurring after LT, and improvement after diet elimination...
November 22, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29155807/a-synbiotic-containing-amino-acid-based-formula-improves-gut-microbiota-in-non-ige-mediated-allergic-infants
#11
David C A Candy, Marleen T J Van Ampting, Manon M Oude Nijhuis, Harm Wopereis, Assad M Butt, Diego G Peroni, Yvan Vandenplas, Adam T Fox, Neil Shah, Christina E West, Johan Garssen, Lucien F Harthoorn, Jan Knol, Louise J Michaelis
BACKGROUND: Prebiotics and probiotics (synbiotics) can modify gut microbiota and have potential in allergy management when combined with amino acid-based formula (AAF) for infants with cow's milk allergy (CMA). METHODS: This multicenter, double-blind, randomized controlled trial investigated the effects of an AAF including synbiotic blend on percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) in feces from infants with suspected non-IgE-mediated CMA...
November 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29149860/anaphylactic-shock-with-methylprednisolone-sodium-succinate-in-a-child-with-short-bowel-syndrome-and-cow-s-milk-allergy
#12
Federica Porcaro, Maria Giovanna Paglietti, Antonella Diamanti, Francesca Petreschi, Alessandra Schiavino, Valentina Negro, Valentina Pecora, Alessandro Fiocchi, Renato Cutrera
BACKGROUND: Medications with methyl-prednisolone sodium succinate containing lactose, which potentially contains traces of cow's milk proteins (CMP), could cause allergic reactions or compromise treatment of acute allergic reactions in sensitized patients. CASE PRESENTATION: We describe the unusual case of a one-year-old child affected by short bowel syndrome and history of severe cow's milk allergy (CMA) and anaphylactic reaction due to intravenous administration of methyl-prednisolone sodium succinate (Solu-Medrol 40 mg, Pfizer)...
November 17, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29138990/non-ige-mediated-adverse-food-reactions
#13
REVIEW
Stephanie A Leonard
PURPOSE OF REVIEW: The purpose of this review is to update what is currently known about the major non-IgE-mediated food allergies: food protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced enteropathy (FPE). These conditions are similar in that symptoms are regulated to the gastrointestinal tract; therefore understanding their specific features is important for diagnosis and management. RECENT FINDINGS: The most progress has been made in understanding FPIES with several recent large cohorts being described...
November 14, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29132675/the-role-of-baked-egg-and-milk-in-the-diets-of-allergic-children
#14
REVIEW
Melissa L Robinson, Bruce J Lanser
Baked egg and baked milk are tolerated by most children who are allergic to hen's egg and cow's milk. Incorporating baked goods into the diets of allergic children may help them outgrow their primary allergy more quickly, with changes observed akin to immunotherapy. Benefits may also include increased quality of life and improved nutritional status. The search for a reliable biomarker to predict tolerance to baked goods is ongoing. Most children with a milk or egg allergy who are not previously tolerating egg or milk in baked goods should be offered an observed oral food challenge...
February 2018: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/29132670/food-protein-induced-enterocolitis-syndrome
#15
REVIEW
Theresa A Bingemann, Puja Sood, Kirsi M Järvinen
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy that usually presents in infancy. Cow's milk, soy, and grains are the most common food triggers. FPIES can present as a medical emergency with symptoms including delayed persistent emesis or diarrhea that can lead to severe dehydration and hemodynamic instability with abnormal laboratory markers. Diagnosis can often be made based on clinical history and noted improvement in symptoms once the suspected triggers have been removed from the diet, with oral food challenge as the gold standard for confirmation of diagnosis in unclear cases...
February 2018: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/29123515/dietary-intervention-with-%C3%AE-lactoglobulin-derived-peptides-and-a-specific-mixture-of-fructo-oligosaccharides-and-bifidobacterium-breve-m-16v-facilitates-the-prevention-of-whey-induced-allergy-in-mice-by-supporting-a-tolerance-prone-immune-environment
#16
Atanaska I Kostadinova, Alba Pablos-Tanarro, Mara A P Diks, Betty C A M van Esch, Johan Garssen, Léon M J Knippels, Linette E M Willemsen
Cow's milk allergy (CMA) prevails in infants and brings increased risk of developing other allergic diseases. Oral administration of specific β-lactoglobulin (BLG)-derived peptides (PepMix) and a specific blend of short- and long-chain fructo-oligosaccharides and Bifidobacterium breve M-16V (FF/Bb) was found to partially prevent CMA development in mice. In this study, we aimed to expand the knowledge on the preventive potential and the underlying mechanisms of this approach. Three-week-old female C3H/HeOuJ mice were orally exposed to PepMix±FF/Bb prior to a 5-week oral sensitization with whole whey and cholera toxin as an adjuvant...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29120788/milk-authenticity-by-ion-trap-proteomics-following-multi-enzyme-digestion
#17
Donatella Nardiello, Anna Natale, Carmen Palermo, Maurizio Quinto, Diego Centonze
The practice of adding adulterating substances in milk in order to raise profits is unfortunately worldwide. In addition, higher priced milk, coming from minor dairy species, is often illegally integrated with the lower priced cow milk. The presence of species-specific proteins, different from those declared in label, may be a serious problem for people with allergies. The development of proper analytical methods is therefore essential to protect consumer benefits and product authenticity. In this study, a proteomic approach for the detection of adulteration processes of specific milks in mixtures is proposed...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29111886/predictive-modelling-of-the-exposure-to-steviol-glycosides-in-irish-patients-aged-1-3-years-with-phenylketonuria-and-cow-s-milk-protein-allergy
#18
Aaron J O'Sullivan, Sandrine Pigat, Cian O'Mahony, Michael J Gibney, Aideen I McKevitt
Children with Phenylketonuria (PKU) and severe cow's milk protein allergy (CMPA) consume prescribed, specially formulated, foods for special medical purposes (FSMPs) as well as restricted amounts of normal foods. These patients are exposed to artificial sweeteners from the consumption of a combination of free and prescribed foods. Young patients with PKU and CMPA have a higher risk of exceeding acceptable daily intakes (ADI) for additives than age-matched healthy children. A predictive modelling approach has been adapted successfully to assess the additive exposure of young patients with PKU and CMPA to artificial sweeteners...
November 7, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29109046/when-should-infants-with-cow-s-milk-protein-allergy-use-an-amino-acid-formula-a-practical-guide
#19
Rosan Meyer, Marion Groetch, Carina Venter
Cow's milk protein allergy (CMPA) is the most common food allergy in childhood and its prevalence ranges between 1.9% and 4.9%. Most children present with CMPA at age less than 1 year and therefore may require a hypoallergenic formula in the absence of breast milk. Hypoallergenic formulas include both extensively hydrolyzed formula (EHF) and amino acid formula (AAF). For most children with a CMPA, an EHF will be sufficient for symptom resolution, as reflected in current guidelines, but there is a subset of children with CMPA where an AAF may be indicated...
November 3, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29098889/cost-effectiveness-of-using-an-extensively-hydrolysed-casein-formula-containing-lactobacillus-rhamnosus-gg-in-managing-infants-with-cow-s-milk-allergy-in-the-us
#20
Julian F Guest, Roger H Kobayashi, Vinay Mehta, Gary Neidich
OBJECTIVE: To estimate the cost-effectiveness of using an extensively hydrolysed casein formula containing the probiotic Lactobacillus rhamnosus GG, (eHCF+LGG; Nutramigen LGG) compared with eHCF alone, and amino acid formulae (AAF) in treating cow's milk allergy (CMA) in the US, from the perspective of third-party insurers and from parents. METHODS: A decision model was used to estimate the probability of cow's milk allergic infants developing tolerance to cow's milk by 18 months...
November 3, 2017: Current Medical Research and Opinion
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