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https://www.readbyqxmd.com/read/29929107/in-utero-programming-and-early-detection-of-cardiovascular-disease-in-the-offspring-of-mothers-with-obesity
#1
REVIEW
Karolien Van De Maele, Roland Devlieger, Inge Gies
The offspring of women with obesity during their pregnancy are exposed to an altered intra-uterine environment. A subsequent influence on the cardiovascular development during fetal life is assumed. In the present thematic review, we report on the current knowledge about this early development of cardiovascular disease from fetal life until adolescence. Based on animal studies, different contributing mechanisms have been hypothesized that still need confirmation in human subjects. Insulin resistance, increased levels of leptin, chronic inflammatory state, perturbation of sympathetic tone and epigenetic modifications contribute to a suboptimal nutrient environment and changed hemodynamics...
June 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29929039/combination-of-the-fetal-urinary-metabolome-and-peptidome-for-the-prediction-of-postnatal-renal-outcome-in-fetuses-with-puv
#2
Bénédicte Buffin-Meyer, Julie Klein, Benjamin Breuil, Françoise Muller, Panagiotis Moulos, Marion Groussolles, Ourdia Bouali, Jean-Loup Bascands, Stéphane Decramer, Joost P Schanstra
Most of biomarker panels, extracted from single omics traits, still need improvement since they display a gray zone where prediction is uncertain. Here we verified whether a combination of omics traits, fetal urinary metabolites and peptides analyzed in the same sample, improved prediction of postnatal renal function in fetuses with posterior urethral valves (PUV) compared to individual omics traits. Using CE-MS, we explored the urinary metabolome of 13 PUV fetuses with end stage renal disease (ESRD) and 12 PUV fetuses without postnatal ESRD at 2 years postnatally...
June 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29929010/detection-of-fetal-subchromosomal-aberration-with-cell-free-dna-screening-led-to-diagnosis-of-parental-translocation-review-of-11344-consecutive-cases-in-a-university-hospital
#3
Ye-Qing Qian, Xiao-Qing Wang, Min Chen, Yu-Qin Luo, Kai Yan, Yan-Mei Yang, Bei Liu, Li-Ya Wang, Ying-Zhi Huang, Hong-Ge Li, Hang-Yi Pan, Fan Jin, Min-Yue Dong
BACKGROUND: Fetal chromosome aberrations and sub-chromosomal copy number variations (CNVs) are not rare. There are several ways to detect duplications and deletions; cell-free DNA screening (cfDNA screening) is nowadays an accurate and safe detection method. The objective of this study is to report the feasibility of cfDNA screening as an indicator of parental balanced chromosome translocation. RESULTS: From February 2015 to March 2016, cfDNA screening was offered to 11344 pregnant women...
June 18, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29928988/farletuzumab-a-monoclonal-antibody-directed-against-folate-receptor-alpha-shows-no-evidence-of-teratogenicity-in-cynomolgus-monkeys
#4
Tomoyuki Moriyama, Dai Kakiuchi, Luigi Grasso, David L Hutto, Danielle Fernando, Charles Schweizer
Farletuzumab is a humanized monoclonal antibody targeting human folate receptor alpha, which is being developed as an anti-cancer drug. A non-human primate reproductive study was conducted to evaluate whether it could cause any embryonic or fetal abnormalities. Farletuzumab was administered intravenously to pregnant cynomolgus monkeys (n = 16/group) at doses of 0 or 67.5 mg/kg once weekly during gestation day (GD) 20 through 97. C-section was performed on GD100 ± 2, and fetuses were evaluated for morphologic (external, visceral and skeletal) effects...
June 18, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29928977/the-melas-mutation-m-3243a-g-promotes-reactivation-of-fetal-cardiac-genes-and-an-epithelial-mesenchymal-transition-like-program-via-dysregulation-of-mirnas
#5
Salvador Meseguer, Joaquin Panadero, Carmen Navarro-González, Magda Villarroya, Rachid Boutoual, Giacomo Pietro Comi, M-Eugenia Armengod
The pathomechanisms underlying oxidative phosphorylation (OXPHOS) diseases are not well-understood, but they involve maladaptive changes in mitochondria-nucleus communication. Many studies on the mitochondria-nucleus cross-talk triggered by mitochondrial dysfunction have focused on the role played by regulatory proteins, while the participation of miRNAs remains poorly explored. MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is mostly caused by mutation m.3243A>G in mitochondrial tRNALeu(UUR) gene...
June 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29928934/study-on-the-developmental-toxicity-of-%C3%AE-ionone-in-the-rat
#6
Flávia C M Pinto, Rosangela R De-Carvalho, Ana Cecilia A X De-Oliveira, Isabella F Delgado, Francisco J R Paumgartten
β-ionone (BIO) is used in fragrances, toiletries and non-cosmetic products, and as a flavor food additive. Notwithstanding the widespread human exposure, there are limited data on the reproductive toxicity of BIO. This study evaluated the developmental toxicity of BIO (0, 125, 250, 500 and 1000 mg/kg body weight/day) given orally to rats on days 6-15 of gestation (GD6-15). C-section was on GD21 and implantations, living and dead fetuses and resorptions were recorded. Fetuses were weighed, and examined for external abnormalities and skeleton and visceral anomalies...
June 18, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29928930/effect-of-estetrol-a-selective-nuclear-estrogen-receptor-modulator-in-mouse-models-of-arterial-and-venous-thrombosis
#7
Marie-Cécile Valéra, Emmanuelle Noirrit-Esclassan, Marion Dupuis, Coralie Fontaine, Françoise Lenfant, Anne Briaux, Cendrine Cabou, Cedric Garcia, Olivier Lairez, Jean-Michel Foidart, Bernard Payrastre, Jean-François Arnal
Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, and the physiological role of this hormone is unknown. Interestingly, E4 was recently evaluated in preclinical and phase II-III clinical studies in combination with a progestin, with the advantage to not increase the circulating level of coagulation factors, at variance to oral estradiol or ethinylestradiol. Here, we evaluated the effect of E4 on hemostasis and thrombosis in mouse. Following chronic E4 treatment, mice exhibited a prolonged tail-bleeding time and were protected from arterial and also venous thrombosis in vivo...
June 18, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29928928/the-human-genital-tubercle-is-steroidogenic-organ-at-early-pregnancy
#8
I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O Söder, K Svechnikov
It is generally accepted that androgens produced by fetal Leydig cells (FLC) control proper masculinization of the male external genitalia. Here, we hypothesized that the human genital tubercle (GT) has potential to synthesize androgens independently of FLC at early pregnancy. We observed that human GT of both genders have capacity to synthesize steroids of the Δ4 , Δ5 and alternative pathway of DHT synthesis including the androgen itself. The presence of steroids in the GT was associated with the expression of corresponding steroidogenic enzymes...
June 18, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29928900/characterization-and-comparison-of-human-limbal-explant-cultures-grown-under-defined-and-xeno-free-conditions
#9
Kristyna Brejchova, Peter Trosan, Pavel Studeny, Pavlina Skalicka, Tor Paaske Utheim, Jan Bednar, Katerina Jirsova
Human limbal epithelial cells (LECs) intended for treatment of limbal stem cell deficiency are commonly cultivated on a 3T3 feeder layer with complex culture medium supplemented with fetal bovine serum (FBS). However, FBS is a xenogeneic component containing poorly characterised constituents and exhibits quantitative and qualitative lot-to-lot variations. Human limbal explants were plated on untreated or fibrin coated plastic plates and cultured in two non-xenogeneic media (supplemented with either human serum or platelet lysate only)...
June 18, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29928762/effect-of-choline-supplementation-on-neurological-cognitive-and-behavioral-outcomes-in-offspring-arising-from-alcohol-exposure-during-development-a-quantitative-systematic-review-of-clinical-and-preclinical-studies
#10
Lisa K Akison, Jenny Kuo, Natasha Reid, Roslyn N Boyd, Karen M Moritz
Prenatal alcohol exposure results in cognitive, behavioral and neurological deficits in offspring. There is an urgent need for safe and effective treatments to overcome these effects. Maternal choline supplementation has been identified as a potential intervention. Our objective was to review preclinical and clinical studies using choline supplementation in known cases of fetal alcohol exposure to determine its effectiveness in ameliorating deficits in offspring. A systematic search of six electronic databases was conducted and studies selected by reviewing titles/abstracts against specific inclusion/exclusion criteria...
June 21, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29928686/selection-in-utero-and-population-health-theory-and-typology-of-research
#11
REVIEW
Tim A Bruckner, Ralph Catalano
Public health researchers may assume, based on the fetal origins literature, that "scarring" of birth cohorts describes the population response to modern-day stressors. We contend, based on extensive literature concerned with selection in utero , that this assumption remains questionable. At least a third and likely many more of human conceptions fail to yield a live birth. Those that survive to birth, moreover, do not represent their conception cohort. Increasing data availability has led to an improved understanding of selection in utero and its implications for population health...
August 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29928403/antibody-response-against-cancer-testis-antigens-magea4-and-magea10-in-patients-with-melanoma
#12
Kadri Õunap, Kristiina Kurg, Liisi Võsa, Ülo Maiväli, Marina Teras, Anu Planken, Mart Ustav, Reet Kurg
Melanoma-associated antigen A (MAGEA) represent a class of tumor antigens that are expressed in a variety of malignant tumors, however, their expression in healthy normal tissues is restricted to germ cells of testis, fetal ovary and placenta. The restricted expression and immunogenicity of these antigens make them ideal targets for immunotherapy in human cancer. In the present study the presence of naturally occurring antibodies against two MAGEA subfamily proteins, MAGEA4 and MAGEA10, was analyzed in patients with melanoma at different stages of disease...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928259/first-prenatal-diagnosis-of-a-niemann-pick-disease-type-c2-revealed-by-a-cystic-hygroma-a-case-report-and-review-of-the-literature
#13
Liana Ples, Romina-Marina Sima, Florina Nedelea, Marius Moga
Background: The importance of fetal nuchal translucency was highlighted in the early 1990s as a useful first-trimester marker to identify fetal chromosomal abnormalities. Here, we report the prenatal diagnosis of a fetus with Niemann-Pick disease type C initially identified by first-trimester ultrasonographic markers and eventually confirmed by extensive genetic evaluation. Case presentation: The fetus of a 30-year-old woman exhibited a cystic hygroma in the first trimester of pregnancy...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29928147/associations-between-physical-and-psychosocial-factors-and-health-related-quality-of-life-in-women-who-gave-birth-after-a-kidney-transplant
#14
Yuki Yoshikawa, Junji Uchida, Chiharu Akazawa, Nobuhiko Suganuma
Purpose: Health-related quality of life (HRQOL) among kidney transplant recipients is associated with physical and psychosocial characteristics. Furthermore, pregnancy and childcare may be particularly challenging for women. The aim of this study was to assess the relationship between patients' psychosocial characteristics and HRQOL, specifically for recipients who have given birth after their kidney transplant. Patients and methods: This was a cross-sectional study...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29928002/b-1-cells-and-b-1-cell-precursors-prompt-different-responses-to-wnt-signaling
#15
Lika Osugui, Jolanda J de Roo, Vivian Cristina de Oliveira, Ana Clara Pires Sodré, Frank J T Staal, Ana Flavia Popi
Recently several studies demonstrated a role for the Wnt pathway in lymphocyte development and self-renewal of hematopoietic stem cells (HSCs). B-1 cells constitute a separate lineage of B lymphocytes, originating during fetal hematopoiesis, expressing lymphoid and myeloid markers and possessing self-renewal ability, similar to early hematopoietic progenitors and HSCs. A plethora of studies have shown an important role for the evolutionary conserved Wnt pathway in the biology of HSCs and T lymphocyte development...
2018: PloS One
https://www.readbyqxmd.com/read/29927665/maternal-reproductive-performance-and-fetal-development-of-the-wistar-audiogenic-rat-war-strain
#16
Eduardo H Umeoka, Matheus C Eiras, Iara G Viana, Vanessa S Giorgi, Aline Bueno, Débora C Damasceno, Norberto Garcia-Cairasco, Paula A Navarro
Wistar Audiogenic Rat (WAR) strain is an animal model for epilepsy studies, the chronic multifactorial disease that affects millions of people worldwide. The animals of this strain are genetically predisposed to sound-induced seizures, called audiogenic seizures, and have been used for many years in studies to understand the mechanisms involved in the epilepsies and their neuropsychiatric comorbidities, as well as the screening of potential anti-convulsant agents. Nevertheless, little is known about the reproductive characteristics of these animals...
June 21, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29927503/increases-in-placental-nitric-oxide-but-not-nitric-oxide-mediated-relaxation-underlie-the-improvement-in-placental-efficiency-and-antihypertensive-effects-of-hydrogen-sulphide-donor-in-hypertensive-pregnancy
#17
Jose Sergio Possomato-Vieira, Jessica Sabbatine Chimini, Maria Luiza Santos da Silva, Carlos A Dias-Junior
Dysregulation of hydrogen sulphide (H2 S) producing enzymes has been related to hypertensive pregnancy and H2 S donor, sodium hydrosulphide (NaHS) exerts antihypertensive effects, modulates angiogenic factors production and acts as an antioxidant. Moreover, reduction in nitric oxide (NO) bioavailability is related to hypertensive pregnancy and H2 S may interact with NO, modulating its production. We aimed to investigate the NaHS effects in hypertension-in-pregnancy and also in feto-placental parameters. Female Wistar rats (200-250 g) were mated and desoxycorticosterone acetate injections followed by replacement of water by 0...
June 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29927492/congenital-aqueduct-stenosis-progressive-brain-findings-in-utero-to-birth-in-the-presence-of-severe-hydrocephalus
#18
Beth Kline-Fath, Monica S Arroyo, Maria A Calvo-Garcia, Paul S Horn, Cameron Thomas
PURPOSE: To evaluate the effects of progressive hydrocephalus on the developing brain in a cohort of fetuses diagnosed with congenital aqueduct stenosis (CAS) by comparing prenatal MRI and postnatal imaging. METHODS: This IRB approved single center retrospective review of prenatally diagnosed children with CAS interrogated changes in the brain between prenatal and postnatal imaging and analyzed statistics utilizing SAS ® software package version 9.3. RESULTS: Thirty fetuses imaged at a mean gestational age of 26 weeks had aqueduct obstruction confirmed by postnatal imaging...
June 21, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29927491/second-trimester-maternal-serum-screening-for-fetal-down-syndrome-as-a-screening-test-for-hemoglobin-bart-s-disease-a-prospective-population-based-study
#19
Chanane Wanapirak, Wirawit Piyamomgkol, Supatra Sirichotiyakul, Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Kuntharee Traisrisilp, Phudit Jatavan, Theera Tongsong
OBJECTIVE: To determine the effectiveness of second-trimester maternal serum screening (MSS) for Down syndrome as a screening test for fetal hemoglobin (Hb) Bart's disease among an unselected population. METHODS: A secondary analysis of a large prospective database (20,254 pregnancies) was conducted to compare the levels of MSS, alpha-fetoprotein (AFP), free beta-human chorionic gonadotropin (hCG) and unconjugated estriol (uE3) between pregnancies with Hb Bart's disease and unaffected pregnancies...
June 21, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29926512/potentially-effective-method-for-fetal-gender-determination-by-non-invasive-prenatal-testing-for-x-linked-disease
#20
Yoshiteru Noda, Takema Kato, Asuka Kato, Haruki Nishizawa, Jun Miyazaki, Mayuko Ito, Sumire Terasawa, Takao Sekiya, Takuma Fujii, Hiroki Kurahashi
Examination of maternal plasma cell free DNA (cfDNA) for noninvasive prenatal testing for fetal trisomy is a highly effective method for pregnant women at high risk. This can be also applied to fetal gender determination in female carriers of severe X-linked disease. PCR analysis is a relatively simpler and less expensive method of detecting Y chromosome-specific repeats (Y-specific PCR; YSP), but is limited by the risk of false-negative results. To address this, we have developed a combined strategy incorporating YSP and an estimation of the fetal DNA fraction...
June 21, 2018: Congenital Anomalies
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