keyword
https://read.qxmd.com/read/38547193/impact-of-covid-19-vaccination-on-liver-transplant-recipients-experience-in-a-reference-center-in-mexico
#1
JOURNAL ARTICLE
Daniel Azamar-Llamas, Josealberto Sebastiano Arenas-Martinez, Antonio Olivas-Martinez, Jose Victor Jimenez, Eric Kauffman-Ortega, Cristian J García-Carrera, Bruno Papacristofilou-Riebeling, Fabián E Rivera-López, Ignacio García-Juárez
BACKGROUND AND AIMS: COVID-19 vaccination has proved to be effective to prevent symptomatic infection and severe disease even in immunocompromised patients including liver transplant patients. We aim to assess the impact of COVID-19 vaccination on the mortality and development of severe and critical disease in our center. METHODS: A retrospective cohort study of LT patients in a reference center between March 2020 and February 2022. Demographic data, cirrhosis etiology, time on liver transplantation, immunosuppressive therapies, and vaccination status were recorded at the time of diagnosis...
2024: PloS One
https://read.qxmd.com/read/38547092/oxidative-study-a-pilot-prospective-observational-cohort-study-protocol-examining-the-influence-of-peri-reperfusion-hyperoxemia-and-immune-dysregulation-on-early-allograft-dysfunction-after-orthotopic-liver-transplantation
#2
JOURNAL ARTICLE
Elizabeth A Wilson, Anna Woodbury, Kirsten M Williams, Craig M Coopersmith
Early allograft dysfunction (EAD) is a functional hepatic insufficiency within a week of orthotopic liver transplantation (OLT) and is associated with morbidity and mortality. The etiology of EAD is multifactorial and largely driven by ischemia reperfusion injury (IRI), a phenomenon characterized by oxygen scarcity followed by paradoxical oxidative stress and inflammation. With the expanded use of marginal allografts more susceptible to IRI, the incidence of EAD may be increasing. This necessitates an in-depth understanding of the innate molecular mechanisms underlying EAD and interventions to mitigate its impact...
2024: PloS One
https://read.qxmd.com/read/38546288/nutritional-aspects-of-prehabilitation-in-adults-with-cirrhosis-awaiting-liver-transplant
#3
JOURNAL ARTICLE
Christofer Cruz, Carla M Prado, Chelsia Gillis, Robert Martindale, Chantal Bémeur, Jennifer C Lai, Puneeta Tandon
Malnutrition, sarcopenia (low muscle mass), and physical frailty have gained increasing recognition in candidates for liver transplant (LT) as these conditions can impact postoperative functional capacity. Multidimensional prehabilitation programs have been proposed as a safe intervention in adults awaiting LT but the nutritional pillar of prehabilitation has been understudied. This review summarizes the nutritional recommendations for prehabilitation for individuals with cirrhosis awaiting LT. Three major aspects of nutritional prehabilitation are discussed: (1) Assess: Evaluate nutritional status and assess for malnutrition, sarcopenia, and frailty to guide the nutritional prehabilitation intervention intensity, increasing across universal, targeted, and specialist levels; (2) Intervene: Prescribe a nutritional prehabilitation intervention to meet established nutrition guidelines in cirrhosis with a targeted focus on improving nutritional status and muscle health; (3) Reassess: Follow-up based on the required intensity of nutritional care with as needed intervention adjustment...
March 28, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38545915/stepwise-development-and-expansion-of-an-abdominal-normothermic-regional-perfusion-program-for-donation-after-circulatory-determination-of-death-organ-procurement
#4
JOURNAL ARTICLE
Anji Wall, Priya Arunachalam, Eric Martinez, Richard Ruiz, Hoylan Fernandez, Johanna Bayer, Amar Gupta, Gregory J McKenna, Seung-Hee Lee, Bradley Adams, Douglas Butler, Scott Noesges, Michael Duncan, Murphy Rayle, Kara Monday, Gary Schwartz, Giuliano Testa
INTRODUCTION: Normothermic regional perfusion (NRP) represents an innovative technology that improves the outcomes for liver and kidney recipients of donation after circulatory determination of death (DCD) organs but protocols for abdominal-only NRP (A-NRP) DCD are lacking in the US. METHODS: We describe the implementation and expansion strategies of a transplant-center-based A-NRP DCD program that has grown in volume, geographical reach, and donor acceptance parameters, presented as four eras...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38545890/effect-of-the-opioid-crisis-on-the-liver-transplantation-donor-pool-a-national-analysis
#5
JOURNAL ARTICLE
Yutaka Endo, Kazunari Sasaki, Muhammad Musaab Munir, Selamawit Woldesenbet, Diamantis I Tsilimigras, Erryk Katayama, Jason Yang, Ashley Limkemann, Austin Schenk, Kenneth Washburn, Timothy M Pawlik
BACKGROUND: Over the last decade there has been a surge in overdose deaths due to the opioid crisis. We sought to characterize the temporal change in overdose donor (OD) use in liver transplantation (LT), as well as associated post-LT outcomes, relative to the COVID-19 era. METHODS: LT candidates and donors listed between January 2016 and September 2022 were identified from the Scientific Registry of Transplant Recipients database. Trends in LT donors and changes related to OD were assessed pre- versus post-COVID-19 (February 2020)...
April 2024: Clinical Transplantation
https://read.qxmd.com/read/38544764/the-effect-of-new-acuity-circle-policy-on-simultaneous-liver-and-kidney-transplantation-in-the-united-states
#6
JOURNAL ARTICLE
Kenji Okumura, Abhay Dhand, Ryosuke Misawa, Hiroshi Sogawa, Gregory Veillette, Seigo Nishida
BACKGROUND: New deceased donor liver allocation policy using an acuity circle (AC)-based model was implemented on February 4th, 2020. The effect of AC policy on simultaneous liver-kidney transplantation (SLKT) remains unknown. The aim of this study was to assess the effect of AC policy on SLKT waitlist mortality, transplant probability, and post-transplant outcomes. METHODS: Using the United Network for Organ Sharing database, 4908 adult SLKT candidates during two study periods, pre-AC (Aug-2017 to Feb-2020, N = 2770) and post-AC (Feb-2020 to Dec-2021, N = 2138) were analyzed...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38544563/transplant-trial-watch
#7
EDITORIAL
John M O'Callaghan, John Fallon
No abstract text is available yet for this article.
2024: Transplant International
https://read.qxmd.com/read/38544518/self-reported-symptom-occurrence-and-distress-and-psychological-well-being-after-liver-transplantation-a-descriptive-cross-sectional-study-of-danish-recipients
#8
JOURNAL ARTICLE
Kristine Elberg Dengsø, Andreas Dehlbæk Knudsen, Dina Leth Møller, Anna Forsberg, Susanne Dam Nielsen, Jens Hillingsø
INTRODUCTION: Symptom distress and impaired psychological well-being after liver transplantation may lead to limitations in everyday activities and lowered health-related quality of life. The aim of this nationwide, descriptive, and cross-sectional study was to explore self-reported symptom occurrence and distress, among Danish liver transplant recipients, and their association with self-reported psychological well-being as well as demographic, and clinical characteristics. METHODS: Liver transplant recipients transplanted from 1990 to 2022 were included...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38543737/effects-of-hcv-clearance-with-direct-acting-antivirals-daas-on-liver-stiffness-liver-fibrosis-stage-and-metabolic-cellular-parameters
#9
JOURNAL ARTICLE
Joana Ferreira, Manuel Bicho, Fátima Serejo
INTRODUCTION: Chronic hepatitis C (CHC) is a clinical and pathological syndrome with various causes and is characterized by varying degrees of hepatocellular necrosis and inflammation. It is a significant cause of liver transplantation and liver-related death worldwide. The hepatic manifestations of CHC are typically characterized by slowly progressing liver fibrosis, which is a non-specific and often disproportionate response to tissue damage. A large majority of HCV patients have extrahepatic manifestations with varying degrees of severity...
February 27, 2024: Viruses
https://read.qxmd.com/read/38542753/ginsenoside-rg-5-activates-the-lkb1-ampk-mtor-signaling-pathway-and-modifies-the-gut-microbiota-to-alleviate-nonalcoholic-fatty-liver-disease-induced-by-a-high-fat-diet
#10
JOURNAL ARTICLE
Yingying Shi, Jianbo Chen, Di Qu, Qiang Sun, Yang Yu, Hao Zhang, Zhengbo Liu, Jiyue Sha, Yinshi Sun
The primary objective of this investigation was to elucidate the manner in which ginsenoside Rg5 (Rg5 ) ameliorates nonalcoholic fatty liver disease (NAFLD) via the modulation of the gut microbiota milieu. We administered either a standard diet (ND) or a high-fat diet (HFD), coupled with 12-week treatment employing two distinct doses of Rg5 (50 and 100 mg/kg/d), to male C57BL/6J mice. In comparison to the HFD cohort, the Rg5 -treated group demonstrated significant enhancements in biochemical parameters, exemplified by a substantial decrease in lipid concentrations, as well as the reduced expression of markers indicative of oxidative stress and liver injury...
March 15, 2024: Nutrients
https://read.qxmd.com/read/38542027/cholangiocyte-organoids-the-new-frontier-in-regenerative-medicine-for-the-study-and-treatment-of-cholangiopathies
#11
REVIEW
Serena Babboni, Pier Giuseppe Vacca, Ludovica Simonini, Daniele Pezzati, Caterina Martinelli, Francesco Frongillo, Giuseppe Bianco, Emanuele Marciano, Giuseppina Basta, Davide Ghinolfi, Serena Del Turco
Cholangiopathies include a group of chronic progressive disorders, affecting the cholangiocytes, the epithelial cells that line the biliary tree, leading to liver parenchymal fibrosis and eventually end-stage liver disease necessitating transplantation. Experimental modeling of these multifactorial cholestatic diseases faces challenges due to the lack of adequate experimental in vitro and in vivo models. A novel approach employs three-dimensional organoid systems that offer several advantages for modeling disease and testing drug response in vitro...
March 21, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541954/recipient-survival-among-living-donor-vs-deceased-donor-liver-transplants-for-acute-liver-failure-in-the-united-states
#12
JOURNAL ARTICLE
Eric Moughames, Merve Gurakar, Amir Khan, Marwan Alsaqa, N Begum Ozturk, Alan Bonder, Ahmet Gurakar, Behnam Saberi
Objectives: Acute liver failure (ALF) is associated with high morbidity and mortality. Timely liver transplantation (LT) is the only universally accepted therapy for ALF that is non-responsive to medical therapy. Data regarding the use of living donor LT (LDLT) for this indication in the US is scarce. Materials and Methods : United Network of Organ Sharing/Organ Procurement and Transplantation Network (UNOS/OPTN) data from January 2002 to December 2020 were reviewed. Adult and pediatric recipients listed as status 1 were included...
March 17, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541944/de-novo-metabolic-syndrome-1-year-after-liver-transplantation-and-its-association-with-mid-and-long-term-morbidity-and-mortality-in-liver-recipients
#13
JOURNAL ARTICLE
Kinga Czarnecka, Paulina Czarnecka, Olga Tronina, Teresa Bączkowska, Magdalena Durlik
Background: Metabolic syndrome (MS) constitutes an important source of cardiovascular- and cancer-related morbidity and mortality in the general population. Limited information is available on whether these findings can be directly extrapolated to liver recipients. This study aimed to investigate the impact of post-transplant MS present 1 year after liver transplantation on survival rates, risk of major cardiovascular events (CVEs), and de novo malignancies. Methods: Adult deceased-liver-donor recipients who underwent transplantation in our centre between 2010 and 2019 and reached at least 1 year of post-transplantation follow-up were eligible...
March 16, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541138/evolution-of-liver-transplantation-indications-expanding-horizons
#14
REVIEW
Sara Battistella, Marco Grasso, Elisa Catanzaro, Francesca D'Arcangelo, Giorgia Corrà, Giacomo Germani, Marco Senzolo, Alberto Zanetto, Alberto Ferrarese, Martina Gambato, Patrizia Burra, Francesco Paolo Russo
Liver transplantation (LT) has significantly transformed the prognosis of patients with end-stage liver disease and hepatocellular carcinoma (HCC). The traditional epidemiology of liver diseases has undergone a remarkable shift in indications for LT, marked by a decline in viral hepatitis and an increase in metabolic dysfunction-associated steatotic liver disease (MASLD), along with expanded indications for HCC. Recent advancements in surgical techniques, organ preservation and post-transplant patients' management have opened new possibilities for LT...
February 28, 2024: Medicina
https://read.qxmd.com/read/38541030/the-hemodynamic-profile-and-intraoperative-bleeding-impact-on-liver-transplant-patients
#15
JOURNAL ARTICLE
Lavinia Nicoleta Brezeanu, Cosmina Elena Jercălău, Catalina Liliana Andrei, Octavian Ceban, Gabriela Droc
Liver transplantation is the treatment of choice for end-stage liver disease and despite accumulated experience over the years, improved surgical techniques, better immunosuppression and adequate intensive care management, it still represents the greatest challenge for anesthesiologists. The aim of the study was the characterization of the hemodynamic profile of patients with liver cirrhosis undergoing liver transplantation with the help of the PiCCO system during the three surgical stages, the impact of bleeding on hemodynamic status and correlation between the amount of bleeding, lactate levels, severity scores and survival rate and complications...
March 8, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540965/risk-factors-for-recurrence-of-primary-sclerosing-cholangitis-after-liver-transplantation-single-center-data
#16
JOURNAL ARTICLE
Elisa Catanzaro, Enrico Gringeri, Nora Cazzagon, Annarosa Floreani, Umberto Cillo, Patrizia Burra, Martina Gambato
BACKGROUND: Primary sclerosing cholangitis (PSC), comprising 5-15% of European liver transplantation (LT) cases, poses a significant challenge due to the risk of post-transplant disease recurrence (rPSC). This single-center study aimed to determine the rPSC rate and long-term post-LT outcomes in PSC patients and to identify potentially modifiable risk factors of rPSC. METHODS: All PSC patients receiving LT at Padua Hospital from 1993 to 2021 were included. Recipient data were collected pre-LT, at LT, and during the follow-up...
February 20, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540289/the-use-and-potential-benefits-of-n-acetylcysteine-in-non-acetaminophen-acute-liver-failure-an-etiology-based-review
#17
REVIEW
Mihai Popescu, Angelica Bratu, Mihaela Agapie, Tudor Borjog, Mugurel Jafal, Romina-Marina Sima, Carmen Orban
Acute liver failure represents a life-threatening organ dysfunction with high mortality rates and an urgent need for liver transplantation. The etiology of the disease varies widely depending on various socio-economic factors and is represented mainly by paracetamol overdose and other drug-induced forms of liver dysfunction in the developed world and by viral hepatitis and mushroom poisoning in less developed countries. Current medical care constitutes either specific antidotes or supportive measures to ensure spontaneous recovery...
March 18, 2024: Biomedicines
https://read.qxmd.com/read/38540128/updated-insights-into-probiotics-and-hepatobiliary-diseases
#18
REVIEW
Xiaoyu Xu, Cheng Zhang, Guoyi Tang, Ning Wang, Yibin Feng
Hepatobiliary diseases have a high prevalence worldwide, with a wide range of diseases involved in the liver and biliary system. Modifications in gut microbiota have been proven to have an association with unbalanced intestinal homeostasis and the dysfunction of host metabolism and the immune system, which can be the risk factors for many hepatobiliary diseases, such as nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), nonalcoholic fatty steatohepatitis (NASH), hepatitis, cirrhosis, hepatocellular carcinoma (HCC) and cholestasis, as well as infection due to liver transplantation...
February 25, 2024: Biomedicines
https://read.qxmd.com/read/38539557/early-results-of-a-screening-program-for-skin-cancer-in-liver-transplant-recipients-a-cohort-study
#19
JOURNAL ARTICLE
Delal Akdag, Allan Rasmussen, Susanne Dam Nielsen, Dina Leth Møller, Katrine Togsverd-Bo, Emily Wenande, Merete Haedersdal, Hans-Christian Pommergaard
(1) Background: Skin cancer is the most common cancer in transplant recipients. Timely and regular screening may reduce advanced disease. The study aimed to determine referral rates to screening, the incidence, and risk factors of skin cancer in a Danish liver transplant recipient cohort. (2) Methods: All first-time liver transplant recipients, >18 years old, attending outpatient care between January 2018 and December 2021 were included. The referral rates and incidence of skin cancer/preneoplastic lesions were calculated...
March 20, 2024: Cancers
https://read.qxmd.com/read/38538967/impacts-of-glucagon-like-peptide-1-receptor-agonists-on-the-risk-of-adverse-liver-outcomes-in-patients-with-metabolic-dysfunction-associated-steatotic-liver-disease-cirrhosis-and-type-2-diabetes
#20
JOURNAL ARTICLE
Mohamed I Elsaid, Na Li, Stephen A Firkins, Vinod K Rustgi, Electra D Paskett, Chathur Acharya, K Rajender Reddy, Chien Wei Chiang, Khalid Mumtaz
BACKGROUND/AIMS: We examined the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) initiation on long-term Adverse Liver Outcomes (ALO) in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) cirrhosis and type 2 diabetes using real-world data from the MarketScan database. METHODS: We conducted a retrospective cohort study of patients with MASLD cirrhosis and type 2 diabetes between 2012 and 2020. Cox proportional hazard models examine the association between GLP-1RAs initiation, modelled as time-dependent, and the risk of ALO, a composite endpoint defined by the first occurrence of hepatic decompensation(s), portal hypertension, hepatocellular carcinoma (HCC) or liver transplantation (LT)...
March 27, 2024: Alimentary Pharmacology & Therapeutics
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