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Liver transplantion

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https://www.readbyqxmd.com/read/28742983/should-adults-with-diabetes-mellitus-be-vaccinated-against-hepatitis-b-virus-a-systematic-review-of-diabetes-mellitus-and-the-progression-of-hepatitis-b-disease
#1
Zobair Younossi, Katrin Kochems, Marc de Ridder, Desmond Curran, Eveline M Bunge, Laurence de Moerlooze
Despite the burden of diabetes mellitus (DM), little is known about the role of this and other metabolic syndromes on the severity of hepatitis B virus (HBV) chronicity and liver disease progression. The value of hepatitis B vaccination and its impact on liver diseases and HCC has been largely demonstrated (ref), adult vaccination coverage is however suboptimal and DM diagnosis represents an opportunity for the HCP to discuss hepatitis B and other adult vaccinations. We performed a systematic literature search to identify studies (2000 to January 2017) describing liver disease progression among patients with HBV by DM status...
July 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28742776/venovenous-bypass-is-associated-with-a-lower-incidence-of-acute-kidney-injury-after-liver-transplantation-in-patients-with-compromised-pretransplant-renal-function
#2
Kai Sun, Fu Hong, Yun Wang, Vatche G Agopian, Min Yan, Ronald W Busuttil, Randolph H Steadman, Victor W Xia
BACKGROUND: Although the hemodynamic benefits of venovenous bypass (VVB) during liver transplantation (LT) are well appreciated, the impact of VVB on posttransplant renal function is uncertain. The aim of this study was to determine if VVB was associated with a lower incidence of posttransplant acute kidney injury (AKI). METHODS: Medical records of adult (≥18 years) patients who underwent primary LT between 2004 and 2014 at a tertiary hospital were reviewed. Patients who required pretransplant renal replacement therapy and intraoperative piggyback technique were excluded...
July 21, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28742721/hepatic-portocholecystostomy-97-cases-from-a-single-institution
#3
Géraldine Héry, Emmanuel Gonzales, Olivier Bernard, Virginie Fouquet, Frédéric Gauthier, Sophie Branchereau
OBJECTIVES: About 20% of cases of biliary atresia (BA) do not involve the gallbladder, the cystic duct and the common bile duct. In these cases, a hepatoportocholecystostomy (HPC) may be performed instead of the classical hepatoportoenterostomy (HPE). METHODS: We reviewed our cohort to investigate the efficacy of HPC as well as the associated surgical complications and clinical problems. RESULTS: From 1984 to 2009, 97 patients underwent HPC in our institution...
July 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28742700/comparison-of-postoperative-outcomes-between-donation-after-circulatory-death-and-donation-after-brain-death-liver-transplantation-using-the-comprehensive-complication-index
#4
Marit Kalisvaart, Jubi E de Haan, Wojciech G Polak, Herold J Metselaar, Bas P L Wijnhoven, Jan N M IJzermans, Jeroen de Jonge
OBJECTIVE: To test the total burden of complications in the early postoperative period after liver transplantation (LT) between donation after circulatory death (DCD) and donation after brain death (DBD) grafts with the novel Comprehensive Complication Index (CCI). BACKGROUND: LT is complex surgery and the increasing use of high-risk grafts is pressuring current postoperative outcomes. DCD grafts in particular are associated with ischemic-type biliary lesions (ITBL) with subsequent impaired graft survival rates...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28741362/gastroenterology-evolution-of-specialty-choice-in-recent-years
#5
José Curbelo, José-María Galván-Román, Fernando Sánchez-Lasheras, Jose María Romeo, Ana Fernández-Somoano, Tomás Villacampa, Jaime Baladrón
INTRODUCTION: Gastroenterology is one of the medical specialties offered to residency training candidates each year. This project analyzes the data associated with the choice of a Gastroenterology residency program in recent years. MATERIALS AND METHODS: Data related to specialty selection were obtained from official reports with regard to the allocation of residency places by the Spanish Ministry of Health, Social Services and Equality. Information was collected from various teaching centers via their training guides, the Spanish National Catalogue of Hospitals and the National Transplant Organization...
July 25, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28741309/interventional-radiology-in-the-management-of-the-liver-transplant-patient
#6
REVIEW
Bartley Thornburg, Nitin Katariya, Ahsun Riaz, Kush Desai, Ryan Hickey, Robert Lewandowski, Riad Salem
Liver transplantation is commonly used to treat patients with end-stage liver disease. The evolution of surgical techniques, endovascular methods, and medical care has led to a progressive decrease in post-transplant morbidity and mortality. Despite these improvements, a multi-disciplinary approach to each patient remains essential as the early diagnosis and treatment of the complications of transplantation influence graft and patient survival. The critical role of interventional radiology in the collaborative approach to the care of the liver transplant patient will be reviewed...
July 24, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28741138/trans-splenic-access-for-portal-venous-interventions-in-children-do-benefits-outweigh-risks
#7
Sheena Pimpalwar, Ponraj Chinnadurai, Alberto Hernandez, Kamlesh Kukreja, Shakeel Siddiqui, Henri Justino
BACKGROUND: The primary concern of trans-splenic access for portal interventions is the risk of life-threatening intraperitoneal bleeding. OBJECTIVE: To review the clinical indications and efficacy and evaluate the risk factors for intraperitoneal bleeding during trans-splenic portal interventions in children. MATERIALS AND METHODS: A retrospective review of consecutive patients who underwent trans-splenic portal interventions at a tertiary care pediatric institution between March 2011 and April 2017 was performed...
July 24, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28740953/analysis-of-risk-factors-affecting-coagulopathy-after-donor-hepatectomy-in-a-newly-established-liver-transplant-center
#8
Sema Aktaş, Şinasi Sevmiş, Mehmet Şeker, Esin Korkut, Hamdi Karakayalı
OBJECTIVE: As might be expected, living donor liver surgery is associated with serious morbidity and mortality risks. Coagulopathy after donor hepatectomy is an important risk factor affecting morbidity. In this study, risk factors affecting the development of coagulopathy after donor hepatectomy was evaluated in a newly-established liver transplant center. MATERIAL AND METHODS: A retrospective evaluation of 46 liver donors to whom hepatectomy was applied in Medipol Universty of School of Medicine Department of Organ Transplantation between April 2014 and July 2015 was made...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28740893/stereotactic-body-radiotherapy-sbrt-for-locally-advanced-extrahepatic-and-intrahepatic-cholangiocarcinoma
#9
Kiri A Sandler, Darlene Veruttipong, Vatche G Agopian, Richard S Finn, Johnny C Hong, Fady M Kaldas, Saeed Sadeghi, Ronald W Busuttil, Percy Lee
OBJECTIVES: We report single-institution clinical efficacy and safety outcomes for patients with unresectable locally advanced cholangiocarcinoma who were treated with stereotactic body radiation therapy (SBRT) and a subset of patients who received neoadjuvant SBRT and chemotherapy as part of an orthotopic liver transplantation (OLT) protocol. METHODS AND MATERIALS: From October 2008 to June 2015, 31 consecutive patients with unresectable extrahepatic (n = 25) or intrahepatic (n = 6) cholangiocarcinoma were treated with SBRT and retrospectively analyzed...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740511/safety-and-tolerance-of-donor-derived-mesenchymal-stem-cells-in-pediatric-living-donor-liver-transplantation-the-mystep1-study
#10
Steffen Hartleif, Michael Schumm, Michaela Döring, Markus Mezger, Peter Lang, Marc H Dahlke, Joachim Riethmüller, Alfred Königsrainer, Rupert Handgretinger, Silvio Nadalin, Ekkehard Sturm
BACKGROUND: Calcineurin inhibitors (CNI) have significantly improved patient and graft survival in pediatric liver transplantation (pLT). However, CNI toxicity leads to significant morbidity. Moreover, CNIs cannot prevent long-term allograft injury. Mesenchymal stem (stromal) cells (MSC) have potent immunomodulatory properties, which may promote allograft tolerance and ameliorate toxicity of high-dose CNI. The MYSTEP1 trial aims to investigate safety and feasibility of donor-derived MSCs in pLT...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28739581/a-novel-prognostic-model-for-transplant-free-survival-in-primary-sclerosing-cholangitis
#11
Elisabeth M de Vries, Junfeng Wang, Kate D Williamson, Mariska M Leeflang, Kirsten Boonstra, Rinse K Weersma, Ulrich Beuers, Roger W Chapman, Ronald B Geskus, Cyriel Y Ponsioen
OBJECTIVE: Most prognostic models for primary sclerosing cholangitis (PSC) are based on patients referred to tertiary care and may not be applicable for the majority of patients with PSC. The aim of this study was to construct and externally validate a novel, broadly applicable prognostic model for transplant-free survival in PSC, based on a large, predominantly population-based cohort using readily available variables. DESIGN: The derivation cohort consisted of 692 patients with PSC from the Netherlands, the validation cohort of 264 patients with PSC from the UK...
July 24, 2017: Gut
https://www.readbyqxmd.com/read/28739313/cardiac-amyloidosis-an-update-on-pathophysiology-diagnosis-and-treatment
#12
REVIEW
Omar K Siddiqi, Frederick L Ruberg
The amyloidoses are a group of systemic diseases characterized by organ deposition of misfolded protein fragments of diverse origins. The natural history of the disease, involvement of other organs, and treatment options vary significantly based on the protein of origin. In AL amyloidosis, amyloid protein is derived from immunoglobulin light chains, and most often involves the kidneys and the heart. ATTR amyloidosis is categorized as mutant or wild-type depending on the genetic sequence of the transthyretin (TTR) protein produced by the liver...
July 13, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28738457/-survey-of-economic-burden-of-hepatitis-b-related-diseases-in-12-areas-in-china
#13
Q S Ma, S Liang, H W Xiao, S X Zhang, G H Zhuang, Y H Zou, H Z Tan, J C Liu, Y H Zhang, A Q Xu, L Zhang, X X Feng, D S Hu, F Z Wang, F Q Cui, X F Liang
Objective: Less surveys on the economic burden of hepatitis B (HB)-related diseases have been conducted in China, so the socioeconomic harm caused by the diseases is not clear and the key parameters for economic evaluation of hepatitis B prevention and treatment are lacking. This study aimed to analyze the direct, indirect and intangible expenditures of hospitalized patients with HB-related diseases during hospitalization and during a year in different areas of China. Methods: The hospitals for infectious diseases and the large general hospitals in 12 areas in China were selected in the study...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738434/-perception-of-the-liver-allocation-system-by-different-stakeholders
#14
Christine Englschalk, Markus Guba
The German Transplant Law is the legal basis of the liver allocation system in Germany and is specified by the guidelines of the German Medical Association. These guidelines are based on current medical knowledge. The procedure of developing these guidelines was formalised and made transparent.This survey with 502 participants examines how four current aspects of the allocation system are perceived by different stakeholders (medical staff, patients on the liver transplant list or already transplanted, medical students and non-medical university personnel and students)...
July 24, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28738402/biodistribution-of-liver-derived-mesenchymal-stem-cells-after-peripheral-injection-in-a-hemophilia-a-patient
#15
Etienne M Sokal, Catherine Anne Lombard, Véronique Roelants, Mustapha Najimi, Sharat Varma, Camillo Sargiacomo, Joachim Ravau, Giuseppe Mazza, François Jamar, Julia Versavau, Vanessa Jacobs, Marc Jacquemin, Stéphane Eeckhoudt, Catherine Lambert, Xavier Stéphenne, Françoise Smets, Cédric Hermans
BACKGROUND: With the exception of liver transplantation, there is no cure for hemophilia, which is currently managed by preemptive replacement therapy. Liver-derived stem cells are in clinical development for inborn and acquired liver diseases and could represent a curative treatment for hemophilia A. The liver is a major factor VIII (FVIII) synthesis site, and mesenchymal stem cells have been shown to control joint bleeding in animal models of hemophilia. Adult-derived human liver stem cells (ADHLSCs) have mesenchymal characteristics and have been shown able to engraft in and repopulate both animal and human livers...
August 2017: Transplantation
https://www.readbyqxmd.com/read/28738386/exercise-capacity-impairment-can-predict-postoperative-pulmonary-complications-after-liver-transplantation
#16
Clarissa Bentes de Araújo Magalhães, Ingrid Correia Nogueira, Liegina Silveira Marinho, Elizabeth F Daher, José Huygens P Garcia, Cyntia F G Viana, Pedro Felipe Carvalhedo de Bruin, Eanes Delgado Barros Pereira
BACKGROUND: Postoperative respiratory complications (PRCs) are common after liver transplantation (LT) and contribute significantly to the related morbidity and mortality. OBJECTIVE: The aim of this paper was to determine the incidence of PRCs after LT and the value of simple exercise capacity measures as independent predictors of PRCs. METHODS: We conducted a prospective cohort study of consecutive adults submitted to LT at a University Hospital in Fortaleza Brazil from March 2013 to March 2015...
July 22, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28737603/deceased-donor-liver-size-and-the-sex-based-disparity-in-liver-transplantation
#17
Mary G Bowring, Jessica M Ruck, Christine E Haugen, Allan B Massie, Dorry L Segev, Sommer E Gentry
No abstract text is available yet for this article.
July 21, 2017: Transplantation
https://www.readbyqxmd.com/read/28736976/living-donor-liver-transplantation-for-neonatal-fulminant-hepatitis-due-to-herpes-simplex-virus-infection
#18
Rodrigo Vincenzi, Eduardo A Fonseca, Karina M O Roda, Gilda Porta, Helry L Candido, Marcel R Benavides, Katia R M Leite, Rogerio C Afonso, Plinio Turine-Neto, Cristiane M F Ribeiro, Paulo Chapchap, João Seda-Neto
Although rare, ALF caused by disseminated HSV infection is associated with high mortality in the neonatal population. This condition is often diagnosed relatively late due to the absence of specific signs. We present a case involving a neonate with ALF submitted to living donor liver transplantation without a prior diagnosis. The patient had no skin or mucosal lesions, and IgM serology was negative for HSV-1 and HSV-2. Immunohistochemical staining of the liver explant was positive for herpes virus infection, and the patient subsequently received antiviral drug treatment, with a good outcome...
July 23, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28736953/neutropenia-in-kidney-and-liver-transplant-recipients-risk-factors-and-outcomes
#19
Thomas A Mavrakanas, Marie-Andrée Fournier, Sarah Clairoux, Jacques-Alexandre Amiel, Marie-Eve Tremblay, Donald C Vinh, Christian Coursol, Daniel J G Thirion, Marcelo Cantarovich
No studies have directly compared the key characteristics and outcomes of kidney (KTx) and liver transplantation (LTx) recipients with neutropenia. In this single-center, retrospective, cohort study, we enrolled all adult patients who received a KTx or LTx between 2000 and 2011. Neutropenia was defined as two consecutive absolute neutrophil count (ANC) values <1500/mm(3) in patients without preexisting neutropenia. The first neutropenia episode occurring during the first-year posttransplantation was analyzed...
July 24, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28736017/long-term-outcomes-for-liver-transplant-recipients-in-terms-of-hepatic-encephalopathy
#20
D D You, G S Choi, J M Kim, C H D Kwon, J-W Joh, S-K Lee
BACKGROUND: Liver transplantation (LT) is thought to resolve cognitive deficit due to hepatic encephalopathy (HE). The aim of this study was to determine the factors associated with the outcomes of patients with HE after LT. METHODS: The authors reviewed the medical records of 388 patients with HE who underwent LT from 1996 to 2014. RESULTS: There were 282 patients with grade 1-2 HE and 106 patients classified as grade 3-4. Patients in the latter group had a tendency for a more decompensated hepatic condition than patients with grade 1-2 HE...
July 2017: Transplantation Proceedings
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